amino acid sequence homology


Summary: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Top Publications

  1. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
  2. pmc The HHpred interactive server for protein homology detection and structure prediction
    Johannes Söding
    Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, 72076 Tubingen, Germany
    Nucleic Acids Res 33:W244-8. 2005
  3. pmc An efficient algorithm for large-scale detection of protein families
    A J Enright
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 30:1575-84. 2002
  4. ncbi Protein homology detection by HMM-HMM comparison
    Johannes Söding
    Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, D 72076 Tubingen, Germany
    Bioinformatics 21:951-60. 2005
  5. ncbi The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    Robert Fredriksson
    Department of Neuroscience, Biomedical Center, Box 593, 75 124 Uppsala, Sweden
    Mol Pharmacol 63:1256-72. 2003
  6. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997
  7. pmc Protein database searches using compositionally adjusted substitution matrices
    Stephen F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    FEBS J 272:5101-9. 2005
  8. ncbi CLANS: a Java application for visualizing protein families based on pairwise similarity
    Tancred Frickey
    Max Planck Institut fuer Entwicklungsbiologie, Spemannstrasse 35, 72076 Tuebingen, Germany
    Bioinformatics 20:3702-4. 2004
  9. pmc Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
  10. ncbi Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    J Gyuris
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:791-803. 1993

Detail Information

Publications310 found, 100 shown here

  1. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
    ..The improvement, especially clear with the more difficult test cases, is always visible, regardless of the phylogenetic spread of the sequences in the tests...
  2. pmc The HHpred interactive server for protein homology detection and structure prediction
    Johannes Söding
    Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, 72076 Tubingen, Germany
    Nucleic Acids Res 33:W244-8. 2005
    ..A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at
  3. pmc An efficient algorithm for large-scale detection of protein families
    A J Enright
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Nucleic Acids Res 30:1575-84. 2002
    ..The method has been used to detect and categorise protein families within the draft human genome and the resulting families have been used to annotate a large proportion of human proteins...
  4. ncbi Protein homology detection by HMM-HMM comparison
    Johannes Söding
    Department of Protein Evolution, Max Planck Institute for Developmental Biology Spemannstrasse 35, D 72076 Tubingen, Germany
    Bioinformatics 21:951-60. 2005
    ..Protein homology detection and sequence alignment are at the basis of protein structure prediction, function prediction and evolution...
  5. ncbi The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    Robert Fredriksson
    Department of Neuroscience, Biomedical Center, Box 593, 75 124 Uppsala, Sweden
    Mol Pharmacol 63:1256-72. 2003
    ..Our novel approach of analyzing such large and diverse sequence sets may be useful for studies on GPCRs in other genomes and divergent protein families...
  6. ncbi The complete genome sequence of Escherichia coli K-12
    F R Blattner
    Laboratory of Genetics, University of Wisconsin Madison, 445 Henry Mall, Madison, WI 53706, USA
    Science 277:1453-62. 1997
    ..The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer...
  7. pmc Protein database searches using compositionally adjusted substitution matrices
    Stephen F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    FEBS J 272:5101-9. 2005
    ..In a typical database search, at least one of these criteria is satisfied by over half the related sequence pairs. Compositional substitution matrix adjustment is now available in NCBI's protein-protein version of blast...
  8. ncbi CLANS: a Java application for visualizing protein families based on pairwise similarity
    Tancred Frickey
    Max Planck Institut fuer Entwicklungsbiologie, Spemannstrasse 35, 72076 Tuebingen, Germany
    Bioinformatics 20:3702-4. 2004
    ..AVAILABILITY: CLANS can be downloaded at
  9. pmc Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling
    Hiroshi Abe
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 15:63-78. 2003
    ..These results indicate that both AtMYC2 and AtMYB2 proteins function as transcriptional activators in ABA-inducible gene expression under drought stress in plants...
  10. ncbi Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    J Gyuris
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:791-803. 1993
    ..These experiments identify Cdi1 as a novel type of protein phosphatase that forms complexes with cyclin-dependent kinases...
  11. pmc The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies
    Alison L Cuff
    Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK
    Nucleic Acids Res 37:D310-4. 2009
    ..Information on the degree of structural diversity in each superfamily and structural overlaps between superfamilies can now be downloaded from the CATH website...
  12. ncbi Flexible structure alignment by chaining aligned fragment pairs allowing twists
    Yuzhen Ye
    Program in Bioinformatics and Systems Biology, The Burnham Institute, La Jolla, CA 92037, USA
    Bioinformatics 19:ii246-55. 2003
  13. pmc Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 141:1539-50. 1998
  14. pmc PRALINE: a multiple sequence alignment toolbox that integrates homology-extended and secondary structure information
    V A Simossis
    Bioinformatics Section, Faculty of Sciences, Vrije Universiteit De Boelelaan 1081A, 1081 HV, Amsterdam, The Netherlands
    Nucleic Acids Res 33:W289-94. 2005
    ..The grouping of sequences, on which the alignment is based, can also be visualized as a dendrogram. PRALINE is available at
  15. pmc OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups
    Feng Chen
    Department of Chemistry, Center for Bioinformatics, Penn Genomics Institute, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Nucleic Acids Res 34:D363-8. 2006
    ..OrthoMCL-DB provides a centralized warehouse for orthology prediction among multiple species, and will be updated and expanded as additional genome sequence data become available...
  16. ncbi A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    E Manser
    Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Nature 367:40-6. 1994
    ..This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways...
  17. ncbi A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
    R Mahajan
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 88:97-107. 1997
    ..Inhibition of nuclear protein import resulting from antibodies directed at NPC-associated RanGAP1 cannot be overcome by soluble cytosolic RanGAP1, indicating that GTP hydrolysis by Ran at RanBP2 is required for nuclear protein import...
  18. pmc Common origin of four diverse families of large eukaryotic DNA viruses
    L M Iyer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Virol 75:11720-34. 2001
  19. ncbi Exportin 1 (Crm1p) is an essential nuclear export factor
    K Stade
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0414, USA
    Cell 90:1041-50. 1997
    ..cerevisiae. The presented data are consistent with the conclusion that Crm1p is a carrier for the NES-mediated protein export pathway. We propose CRM1 be renamed exportin 1 (XPO1)...
  20. ncbi Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues
    Tal Pupko
    The Institute of Statistical Mathematics, 4 6 7 Minami Azabu, Minato ku, Tokyo 106 8569, Japan
    Bioinformatics 18:S71-7. 2002
    ..Functionally important regions often correspond to surface patches of slowly evolving residues...
  21. ncbi A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    M Enari
    Department of Genetics, Osaka University Medical School, Suita, Japan
    Nature 391:43-50. 1998
  22. pmc Repression domains of class II ERF transcriptional repressors share an essential motif for active repression
    M Ohta
    Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology AIST, Central 6, Tsukuba 305 8566, Japan
    Plant Cell 13:1959-68. 2001
    ..These zinc finger proteins functioned as repressors, and their repression domains were identified as regions that contained an EAR motif...
  23. pmc Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility
    M F Carlier
    Dynamique du Cytosquelette, Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Cell Biol 136:1307-22. 1997
    ..In conclusion, the function of ADF is not to sequester G-actin. ADF uses ATP hydrolysis in actin assembly to enhance filament dynamics...
  24. ncbi Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
    G A Rouleau
    Centre de recherche en Neuroscience, McGill University, Montreal, Quebec, Canada
    Nature 363:515-21. 1993
    ..Its deduced product has homology with proteins at the plasma membrane and cytoskeleton interface, a previously unknown site of action of tumour suppressor genes in humans...
  25. pmc Using sequence similarity networks for visualization of relationships across diverse protein superfamilies
    Holly J Atkinson
    Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4345. 2009
    ..As a broadly accessible and effective tool for the exploration of protein superfamilies, sequence similarity networks show great potential for generating testable hypotheses about protein structure-function relationships...
  26. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
    ..Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers...
  27. pmc An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
    G N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 16:2802-13. 1996
    ..e., c-myc) of different vertebrate species are regulated by the same factor and maintain similar expression patterns despite significant promoter sequence divergence...
  28. ncbi PISCES: a protein sequence culling server
    Guoli Wang
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Bioinformatics 19:1589-91. 2003
    ..PDB sequences are updated weekly. PISCES can also cull non-PDB sequences provided by the user as a list of GenBank identifiers, a FASTA format file, or BLAST/PSI-BLAST output...
  29. pmc PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
    A Abo
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA
    EMBO J 17:6527-40. 1998
    ..Thus, unlike other members of the PAK family, PAK4 provides a novel link between Cdc42Hs and the actin cytoskeleton. The cellular locations of PAK4 and Cdc42Hs suggest a role for the Golgi in cell morphogenesis...
  30. ncbi B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    H Dong
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nat Med 5:1365-9. 1999
    ..Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses...
  31. pmc Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene
    W G Kelly
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Genetics 146:227-38. 1997
    ..The resulting transgenes show robust expression in both germline and soma. Our results suggest the possibility of concerted mechanisms for silencing unwanted germiline expression of repetitive sequences...
  32. pmc The Transporter Classification Database: recent advances
    Milton H Saier
    Division of Biological Sciences and Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Nucleic Acids Res 37:D274-8. 2009
    ..The availability of these tools has resulted in recognition of distant phylogenetic relationships and tremendous expansion of the information available to TCDB users...
  33. ncbi The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
    M Rothe
    Department of Molecular Biology Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 83:1243-52. 1995
    ..The recruitment of c-IAP1 or c-IAP2 to the TNFR2 signaling complex requires a TRAF2-TRAF1 heterocomplex...
  34. ncbi TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
    P Grüter
    Department of Molecular Biology, University of Geneva, Switzerland
    Mol Cell 1:649-59. 1998
    ..Thus, TAP, like its yeast homolog Mex67p, is a bona fide mRNA nuclear export mediator. TAP is the second cellular RNA binding protein shown to be directly involved in the export of its target RNA...
  35. ncbi The Corynebacterium glutamicum genome: features and impacts on biotechnological processes
    M Ikeda
    Tokyo Research Laboratories, Kyowa Hakko Kogyo, Asahi machi, Machida, 194 8533, Tokyo, Japan
    Appl Microbiol Biotechnol 62:99-109. 2003
    ..How can traditional fermentation benefit from the C. glutamicum genomic data? The path from genomics to biotechnological processes is presented...
  36. ncbi Cell transformation by the superoxide-generating oxidase Mox1
    Y A Suh
    Department of Biochemistry, Emory University Medical School, Atlanta, Georgia 30322, USA
    Nature 401:79-82. 1999
    ..Cells expressing mox1 have a transformed appearance, show anchorage-independent growth and produce tumours in athymic mice. These data link ROS production by Mox1 to growth control in non-phagocytic cells...
  37. ncbi Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targets
    Kenji K Kojima
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
    Mol Biol Evol 21:207-17. 2004
    ..This indicates that the copy number of a target sequence is the primary factor to restrict the variety of sequence specificity of LINEs...
  38. ncbi Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
    S Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    Blood 96:2808-13. 2000
    ..The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (Blood. 2000;96:2808-2813)..
  39. ncbi Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    M Yamabhai
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:31401-7. 1998
    ..We propose that Intersectin is a component of the endocytic machinery...
  40. pmc A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    D N Cox
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 12:3715-27. 1998
    ..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
  41. ncbi Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    T Kitada
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Nature 392:605-8. 1998
    ..Mutations in the newly identified gene appear to be responsible for the pathogenesis of AR-JP, and we have therefore named the protein product 'Parkin'...
  42. ncbi Prokaryotic origin of the actin cytoskeleton
    F van den Ent
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 413:39-44. 2001
    ..Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin...
  43. ncbi Intermediate filaments: structure, dynamics, function, and disease
    E Fuchs
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Annu Rev Biochem 63:345-82. 1994
  44. ncbi Ubiquitin-dependent protein degradation
    M Hochstrasser
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637, USA
    Annu Rev Genet 30:405-39. 1996
    ..This diversity underlies both the high substrate specificity of the ubiquitin system and the variety of regulatory mechanisms that it serves...
  45. ncbi Convergent evolution: the need to be explicit
    R F Doolittle
    Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0634
    Trends Biochem Sci 19:15-8. 1994
    ..Functional and mechanistic convergence are both common, and some structural convergence has probably occurred, but a convincing case for genuine sequence convergence has yet to be made...
  46. ncbi Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
    ..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin...
  47. pmc New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system
    Vivek Anantharaman
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Genome Biol 4:R81. 2003
    ..The RelE toxin cleaves ribosome-associated transcripts, whereas another post-segregational cell killing toxin, ParE, functions as a gyrase inhibitor...
  48. ncbi Combinatorial receptor codes for odors
    B Malnic
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:713-23. 1999
    ..Our studies also indicate that slight alterations in an odorant, or a change in its concentration, can change its "code," potentially explaining how such changes can alter perceived odor quality...
  49. ncbi OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28
    C Alexander
    Department of Molecular Genetics, Insititute of Ophthalmology, University College London, London, UK
    Nat Genet 26:211-5. 2000
    ..The presence of consensus signal peptide sequences suggests that the product of the gene OPA1 is targeted to mitochondria and may exert its function in mitochondrial biogenesis and stabilization of mitochondrial membrane integrity...
  50. ncbi GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins
    E M Ross
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    Annu Rev Biochem 69:795-827. 2000
    ..GAPs are regulated by various controls of their cellular concentrations, by complex interactions with G¿ or with G¿5 through an endogenous G-like domain, and by interaction with multiple other proteins...
  51. pmc Bioinformatic analysis of the CLE signaling peptide family
    Karsten Oelkers
    School of Biochemistry and Molecular Biology, The Australian National University, Canberra, ACT, Australia
    BMC Plant Biol 8:1. 2008
  52. ncbi A candidate prostate cancer susceptibility gene at chromosome 17p
    S V Tavtigian
    Myriad Genetics, Inc, Salt Lake City, Utah, USA
    Nat Genet 27:172-80. 2001
  53. ncbi Investigating the origins of triploblasty: 'mesodermal' gene expression in a diploblastic animal, the sea anemone Nematostella vectensis (phylum, Cnidaria; class, Anthozoa)
    Mark Q Martindale
    Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii, 41 Ahui Street, Honolulu, HI 96813, USA
    Development 131:2463-74. 2004
    ..Alternatively, we consider the possibility that the diploblastic condition of cnidarians is a secondary simplification, derived from an ancestral condition of triploblasty...
  54. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  55. ncbi A genome phylogeny for mitochondria among alpha-proteobacteria and a predominantly eubacterial ancestry of yeast nuclear genes
    Christian Esser
    Institute of Botany III, University of Dusseldorf, Dusseldorf, Germany
    Mol Biol Evol 21:1643-60. 2004
    ..Among eubacteria and archaebacteria, proteobacterial and methanogen genomes, respectively, shared more similarity with the yeast genome than other prokaryotic genomes surveyed...
  56. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  57. ncbi Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
    S Urban
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Cell 107:173-82. 2001
    ..Rhomboid-1 is conserved throughout evolution from archaea to humans, and our results show that a human Rhomboid promotes Spitz cleavage by a similar mechanism. This growth factor activation mechanism may therefore be widespread...
  58. ncbi Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
    Min Hu
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, NJ 08544, USA
    Cell 111:1041-54. 2002
    ..Binding by ubiquitin aldehyde induces a drastic conformational change in the active site that realigns the catalytic triad residues for catalysis...
  59. ncbi APC binds to the novel protein EB1
    L K Su
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231, USA
    Cancer Res 55:2972-7. 1995
    ..This conservation suggests an essential function for EB1 that might provide clues to the mechanism through which APC suppresses colonic neoplasia...
  60. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    ..The rTACE provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of TNF-alpha production...
  61. ncbi fork head domain genes in zebrafish
    J Odenthal
    MPI für Entwicklungsbiologie, Spemannstrasse 35 III, D 72076 Tubingen, Germany
    Dev Genes Evol 208:245-58. 1998
    ..fkd6 is strongly expressed in neural crest cells from early stages on, whereas fkd2 and fkd7 are transcribed in individual neural crest cells in the pharyngula period...
  62. ncbi KIR: diverse, rapidly evolving receptors of innate and adaptive immunity
    Carlos Vilches
    Servicio de Inmunologia, Hospital Universitario Clinica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain
    Annu Rev Immunol 20:217-51. 2002
    ..This diversity likely contributes variability to the function of NK cells and T-lymphocytes by modulating innate and adaptive immune responses to specific challenges...
  63. ncbi Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
    Botond Banfi
    Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, Switzerland
    J Biol Chem 278:3510-3. 2003
    ..In conclusion, NOX1 is a superoxide-generating enzyme that is activated by two novel proteins, which we propose to name NOXO1 (NOX organizer 1) and NOXA1 (NOX activator 1)...
  64. pmc Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotation
    Nitin Gupta
    Bioinformatics Program, University of California San Diego, La Jolla, California 92093, USA
    Genome Res 17:1362-77. 2007
    ..This study demonstrates that complementing every genome sequencing project by an MS/MS project would significantly improve both genome and proteome annotations for a reasonable cost...
  65. pmc SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton
    Farhana Haque
    Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    Mol Cell Biol 26:3738-51. 2006
    ..Our data provide evidence of a physical nuclear-cytoskeletal connection that is likely to be a key mechanism in nuclear-cytoplasmic communication and regulation of nuclear position...
  66. ncbi A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
    T Hirano
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Cell 79:449-58. 1994
    ..These motifs are highly conserved in a protein family, members of which have been identified recently in both prokaryotes and eukaryotes...
  67. ncbi A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Nature 387:620-4. 1997
    ..Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors...
  68. ncbi Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
    R A Frye
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, 15240, USA
    Biochem Biophys Res Commun 260:273-9. 1999
    ..These results suggest that the sirtuins may function via mono-ADP-ribosylation of proteins...
  69. ncbi The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    T Serafini
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
    Cell 78:409-24. 1994
    ..elegans. This homology suggests that growth cones in the vertebrate spinal cord and the nematode are responsive to similar molecular cues...
  70. pmc A plasma membrane-bound putative endo-1,4-beta-D-glucanase is required for normal wall assembly and cell elongation in Arabidopsis
    F Nicol
    Laboratoire de Biologie Cellulaire, Institut National de Recherche Agronomique, Route de Saint Cyr, F 78026 Versailles Cedex, France
    EMBO J 17:5563-76. 1998
    ..Although the in vivo substrate remains to be determined, the mutant phenotype is consistent with a central role for KOR in the assembly of the cellulose-hemicellulose network in the expanding cell wall...
  71. ncbi Modular recognition of RNA by a human pumilio-homology domain
    Xiaoqiang Wang
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell 110:501-12. 2002
    ..We have mutated these three side chains in one repeat, thereby altering the sequence specificity of Pumilio1. Thus, the high affinity and specificity of the PUM-HD for RNA is achieved using multiple copies of a simple repeated motif...
  72. ncbi Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
    Victor Quesada
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, Spain
    Biochem Biophys Res Commun 314:54-62. 2004
  73. pmc ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins
    Edouard De Castro
    Swiss Institute of Bioinformatics, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Nucleic Acids Res 34:W362-5. 2006
    ..Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results...
  74. ncbi MUSTANG: a multiple structural alignment algorithm
    Arun S Konagurthu
    Department of Computer Science and Software Engineering, The University of Melbourne, Parkville, Melbourne, Victoria, 3010 Australia
    Proteins 64:559-74. 2006
  75. ncbi Convergent evolution of domain architectures (is rare)
    Julian Gough
    RIKEN Genomic Sciences Centre, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Bioinformatics 21:1464-71. 2005
    ..We use a range of methods including phylogenetic grouping, sequence similarity/alignment, mutation rates and comparative genomics to approach this difficult problem from several angles...
  76. ncbi Protein modification by SUMO
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Biochem 73:355-82. 2004
    ..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
  77. ncbi THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases
    L Aravind
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Trends Biochem Sci 26:215-7. 2001
    ..We predict that this domain is an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8...
  78. pmc STRING: known and predicted protein-protein associations, integrated and transferred across organisms
    Christian von Mering
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 33:D433-7. 2005
    ..STRING currently holds 730,000 proteins in 180 fully sequenced organisms, and is available at
  79. ncbi A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction
    J Li
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 90:929-38. 1997
    ..The extracellular domain contains 25 tandem leucine-rich repeats that resemble repeats found in animal hormone receptors, plant disease resistance genes, and genes involved in unknown signaling pathways controlling plant development...
  80. ncbi Molecular characteristics of insect vitellogenins and vitellogenin receptors
    T W Sappington
    Department of Entomology, Michigan State University, East Lansing 48824, USA
    Insect Biochem Mol Biol 28:277-300. 1998
  81. ncbi The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    B Conradt
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 93:519-29. 1998
    ..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
  82. ncbi Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast
    Q Xu
    Burnham Institute Program on Apoptosis and Cell Death Research La Jolla, California 92037, USA
    Mol Cell 1:337-46. 1998
    ..Conversely, BI-1 antisense induced apoptosis. BI-1 thus represents a new type of regulator of cell death pathways controlled by Bcl-2 and Bax...
  83. pmc Matt: local flexibility aids protein multiple structure alignment
    Matthew Menke
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 4:e10. 2008
    ..We postulate that Matt's strong performance comes from its ability to model proteins in different conformational states and, perhaps even more important, its ability to model backbone distortions in more distantly related proteins...
  84. ncbi Evolutionary rate in the protein interaction network
    Hunter B Fraser
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 296:750-2. 2002
    ..We confirm one predicted outcome of this process-namely, that interacting proteins evolve at similar rates...
  85. ncbi A forkhead-domain gene is mutated in a severe speech and language disorder
    C S Lai
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 413:519-23. 2001
    ..Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language...
  86. pmc Mutations in the K+ channel signature sequence
    L Heginbotham
    Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115
    Biophys J 66:1061-7. 1994
    ..Furthermore, the results illustrate that the hydroxyl groups at the third and fourth positions, and the aromatic group at position seven, are not essential in determining K+ selectivity...
  87. ncbi A novel superoxide-producing NAD(P)H oxidase in kidney
    A Shiose
    Department of Molecular and Structural Biology, Kyushu University Graduate School of Medical Science, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 276:1417-23. 2001
    ..The present findings thus suggest that the novel NAD(P)H oxidase NOX4 may serve as an oxygen sensor and/or a regulator of cell growth in kidney...
  88. ncbi Characterization of mammalian selenoproteomes
    Gregory V Kryukov
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    Science 300:1439-43. 2003
    ..The human selenoproteome consists of 25 selenoproteins...
  89. ncbi Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein
    F Mueller-Pillasch
    Department of Internal Medicine I, University of Ulm, Germany
    Oncogene 14:2729-33. 1997
    ..However, the precise role of koc in human tumour cells is unknown and remains to be elucidated...
  90. ncbi An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
    E Zanaria
    Universita di Pavia, Italy
    Nature 372:635-41. 1994
    ..DAX-1 encodes a new member of the nuclear hormone receptor superfamily displaying a novel DNA-binding domain. The DAX-1 product acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor...
  91. ncbi Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    M Ollmann
    Exelixis, Inc, South San Francisco, California 94080, USA
    Cell 101:91-101. 2000
    ..These data reveal an ancestral proapoptotic function for p53 and identify Drosophila as an ideal model system for elucidating the p53 apoptotic pathway(s) induced by DNA damage...
  92. ncbi A mechanism for Wnt coreceptor activation
    Keiko Tamai
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 13:149-56. 2004
    ..Our study identifies a critical signaling module and a key phosphorylation-dependent activation step of the Wnt receptor complex and reveals a unifying logic for transmembrane signaling by Wnts, growth factors, and cytokines...
  93. ncbi PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    J Li
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Science 275:1943-7. 1997
    ..These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions...
  94. ncbi Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structure
    David A D Parry
    Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    J Struct Biol 163:258-69. 2008
    ..An important development has been the recognition that the delightful simplicity that exists between sequence and structure, and between structure and function, allows coiled coils with specialized features to be designed de novo...
  95. pmc Colicin biology
    Eric Cascales
    Laboratoire d Ingénierie des Systèmes Macromoléculaires, Institut de Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, UPR 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Microbiol Mol Biol Rev 71:158-229. 2007
    ..The mechanisms of inhibition by specific and cognate immunity proteins are presented. Finally, the use of colicins as laboratory or biotechnological tools and their mode of evolution are discussed...
  96. ncbi Toward a description of the sialome of the adult female mosquito Aedes aegypti
    J G Valenzuela
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892 0425, USA
    Insect Biochem Mol Biol 32:1101-22. 2002
    ..The possible role of these proteins in blood and sugar feeding by the mosquito is discussed...
  97. pmc KH domain: one motif, two folds
    N V Grishin
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Nucleic Acids Res 29:638-43. 2001
    ..Current analysis offers a new look on how proteins can change fold in the course of evolution...
  98. ncbi Identification of human Rap1: implications for telomere evolution
    B Li
    The Rockefeller University, New York, New York 10021, USA
    Cell 101:471-83. 2000
    ..We propose that budding yeast preserved Rap1 at telomeres but lost the TRF component, possibly concomitant with a change in the telomeric repeat sequence...
  99. pmc Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 33:727-37. 2009
    ..These data indicate Sac3(CID) provides a scaffold within TREX-2 to integrate interactions between protein complexes to facilitate the coupling of transcription and mRNA export during gene expression...
  100. ncbi Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis
    S Iuchi
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 27:325-33. 2001
    ..We improved drought tolerance by gene manipulation of AtNCED3 causing the accumulation of endogenous ABA...
  101. pmc Microtubule actin cross-linking factor (MACF): a hybrid of dystonin and dystrophin that can interact with the actin and microtubule cytoskeletons
    C L Leung
    Department of Pathology and Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 147:1275-86. 1999
    ..The properties of MACF are consistent with the observation that mutations in kakapo cause disorganization of microtubules in epidermal muscle attachment cells and some sensory neurons...

Research Grants63

  1. Mapping the D2/D3 Dopamine Receptor Binding Sites
    ROBERT LUEDTKE; Fiscal Year: 2004
    ..neuropsychiatric disorders or drug abuse because the D2 and D3 dopamine receptors have a high degree of amino acid sequence homology within the transmembrane spanning regions, which construct the neutotransmitter binding site...
  2. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    SUNIL CHATTERJEE; Fiscal Year: 2007
    ..whether the idio-peptides, (LCD-2 and CEA-B) derived from the structure of 3H1 and CEA based on the amino acid sequence homology, which also induce CD4+Th1 help will be more immunogenic in combination with the agonist CTL peptides ..
  3. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ..that this relationship is due to the prevalence of hyperinsulinemia in obese women, since insulin has amino acid sequence homology, as well as mitogenic/anti-apoptotic activity, in common with IGF-I...
  4. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013
    ..Aside from being an integral membrane protein, Orai has no significant amino acid sequence homology to other known ions channels...
  5. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..these approaches and others are viable ones, one of the reasons for their limited success is the high amino acid sequence homology among the cloned receptors...
  6. Function of Longus Type IV pili in enterotoxigenic E coli
    OSCAR GOMEZ; Fiscal Year: 2010
    ..Information that Longus is immunogenic across variants and that anti-Longus antibodies may block colonization and prevent disease will facilitate the construction of effective ETEC vaccines. ..
  7. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2013
    ..With this in mind, the heme uptake pathway provides a number of good protein targets for the development of therapeutics against TB. ..
  8. Mouse modeling of a human STING gene variant for infectious disease
    John C Cambier; Fiscal Year: 2013
    ..It is noteworthy that mouse and human STING proteins share 83% amino acid sequence homology. Thus in the first model (mHAQ mouse), we will make a STING knock-in in which the mouse equivalent ..
  9. Development and Maintenance of PANTHER Software
    Paul D Thomas; Fiscal Year: 2010
    ..The results from this methodology will be made broadly available to both researchers and the public, in formats accessible to both people and computers. ..
    Kenneth Fang; Fiscal Year: 2000
    ..of dog homologues of human MMPs by characterization of substrate specificities and determination of amino acid sequence homology, followed by enzyme purification using sequential chromatographic steps...
    H Seifert; Fiscal Year: 1993
    ..Gonococcal pilin is a member of a family of pilins that share amino acid sequence homology. The pilin genes from N...
    David Stein; Fiscal Year: 2002 a general mechanism for the regulation of transcription factors and the dorsal gene shares amino acid sequence homology with a number of vertebrate transcription factors whose activities are also regulated in this way...
    Jean Bidlack; Fiscal Year: 2007
    ..This chemokine receptor, U51, shares considerable amino acid sequence homology and similarity with the kappa opioid receptor...
    Catherine Willett; Fiscal Year: 2002
    ..The toxicity testing and drug screening markets are estimated at $500M and $700M, respectively. ..
    LAWRENCE SCHEVING; Fiscal Year: 1993
    ..This peptide has been shown to have core amino acid sequence homology with peptides released by other bacteria and by eukaryotic organisms. Such strains of E...
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..
  17. Genetic Analysis of Iron Homeostasis in Zebrafish
    Paula Fraenkel; Fiscal Year: 2006
    ..These novel genes may become molecular targets for the treatment of iron overload conditions, such as hereditary hemochromatosis. ..
  18. 11th & 12th Conference on Cancer Therapy with Antibodies and Immunoconjugates
    David Goldenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
    WAYNE FRANKEL; Fiscal Year: 2001
    ..The identification of mutants with altered neuroexcitability has added value in enriching for other neurobehavioral abnormalities that are difficult to detect in high-throughput screens. ..
  20. Effect of ethanol on retinoid metabolism and signaling in zebrafish embryos
    WILLIAM BOSRON; Fiscal Year: 2007
    ..We will assess the feasibility of performing targeted proteomics studies with tissues from other populations that express different SNPs in alcohol metabolizing enzymes. [unreadable] [unreadable] [unreadable]..
  21. Dynamically Crosslinked Hydrogels
    Russell Stewart; Fiscal Year: 2006
    ..These novel hydrogels may find wide ranging biomedical applications in drug delivery, as active surface coatings or microactuators in medical devices. ..
    WAYNE FRANKEL; Fiscal Year: 2005
    ..Finally, Aim 4 will attempt to gain insight into possible redundancy and action of fidget-related genes by expression studies, modifier gene mapping, and gene targeting. ..
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
    Ira Ropson; Fiscal Year: 2003
    ..Single-site mutant proteins will be generated and studied for their effects on the transition state in protein folding. ..
  25. The Role of surfactant protein genetic variants in cyst*
    Joanna Floros; Fiscal Year: 2005
    ..aeruginosa and its clearance, and provide the basis for further consideration of novel therapeutic strategies to treat CF-related lung disease. ..
  26. High-Accuracy Models of Proteins from Remote Homology
    Jie Liang; Fiscal Year: 2009
    ..These computational capabilities could have profound impacts to drug design and disease studies. ..
  27. CPT11 activation by carboxylesterases in colon cancer
    WILLIAM BOSRON; Fiscal Year: 2003
    ..If there is a positive correlation, a future multi-institutional study will be proposed. ..
    Joanna Floros; Fiscal Year: 2010
    ..Knowledge gained may help explain and perhaps link the in vitro data with the human genetic association data, and provide insight in the understanding of the value of the SP-A gene duplication. ..
  29. Development of RNAi as Treatment for Neurodegeneration
    KENNETH KOSIK; Fiscal Year: 2005
    ..These experiments open the way for the Colombian scientists to participate directly in the next phase of the research beyond descriptive genetics in which the Colombian group has made such a strong contribution. ..
    Valley J Stewart; Fiscal Year: 2010
    ..Thus, results from the model species E. coli enhance understanding for a broad range of pathogens that significantly impact public health. ..
  31. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
  32. The biology of gastrin-ferric ion complexes
    GRAHAM BALDWIN; Fiscal Year: 2009
    ..Recognition that metal ions are essential for the biological activity of NAGs may permit the development of novel therapies for colon cancer. ..
  33. Energy metabolism and virulence of Bordetella species
    Imke Schroeder; Fiscal Year: 2008
    ..The relative contributions of cytochrome oxidase to the infectious cycle will be analyzed in Aim 3 using high-resolution animal models of respiratory tract infection. ..
  34. Combined Methods for Protein-Structure Prediction
    Kevin Karplus; Fiscal Year: 2007
  35. Apoptosis Signaling: BH3 to BH123 Proteins
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  36. Retinoid Metabolism in Hepatitic Stellate Cells
    WILLIAM BOSRON; Fiscal Year: 2005
    ..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
  37. Attenuating sterol synthesis in WT and NPC mice brains
    Ta Yuan Chang; Fiscal Year: 2005
    ..Specific Aim 3: To examine the long-term effect of SSI CP-340868 at 2 different doses on life spans of normal and NPC1 mice. ..
  38. HER 2/Neu--A Target For Cancer Immunotherapy
    MALAYA CHATTERJEE; Fiscal Year: 2005
    ..This study will be a prelude to clinical trials for HER2/neu positive cancer patients with a single or combined anti-Id vaccine. ..
  39. Epidemiology of HIV-1/HIV-2 Dual Infection
    Geoffrey Gottlieb; Fiscal Year: 2005
    JAMES FERRY; Fiscal Year: 2003
    ..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
    ANTHONY PEGG; Fiscal Year: 2009
    ..abstract_text> ..
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
    TERENCE KIRLEY; Fiscal Year: 2004
    ..abstract_text> ..
    WAYNE FRANKEL; Fiscal Year: 2001
    ..In Specific Aim 4, transgenic approaches will be undertaken to functionally analyze the pintail gene and its role in cell type specific control of cell proliferation. ..
  45. 9/10TH Conf./Cancer Therapy/Antibody/Immunoconjugates
    David Goldenberg; Fiscal Year: 2004
    ..The conference chairman, Dr. Goldenberg, has secured two outstanding scientists as co-chairmen, Drs. Ralph Reisfeld (Scripps) and Edward Sausville (NCI). ..
  46. Biomolecular Analysis of Proteins in Visual Disease
    ESTHER BISWAS FISS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. Structure of Microsomal Enzymes in Estrogen Biosynthesis
    Debashis Ghosh; Fiscal Year: 2005
    KENNETH KOSIK; Fiscal Year: 2003
  49. Self-immobilizing Proteins
    Russell Stewart; Fiscal Year: 2005
    ..The widely expected future impact of protein arrays on clinical diagnosis and other areas of human health care may be realized more quickly with new and effective protein modification technology. ..
  50. Chromaffin Cell physiology: Novel molecular approaches
    Sushil Mahata; Fiscal Year: 2009
    ..These studies, utilizing unique knockout, transgenic, and human variants of catestatin, are likely to establish novel catestatin mechanisms in the development of hypertension and its modulation through nicotinic-cholinergic receptors. ..
  51. Beta-cell Granule Protein Profile by Split Reporter Ass*
    Regina Kuliawat; Fiscal Year: 2005
    ..abstract_text> ..
  52. Development of Cdk5 Inhibitors
    KENNETH KOSIK; Fiscal Year: 2007
    ..Because compound validation requires a broad expertise that is unlikely to be present in a single lab we have assembled individuals who collectively have the expertise to complete the aims. ..
  53. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  54. Role of cytochrome oxidases in Bordetella pathogenesis
    Imke Schroeder; Fiscal Year: 2007
    ..Jeffrey F. Miller as co-investigator. Although this study is exploratory in nature Dr. Miller brings extensive expertise on Bordetella genetics and pathogen-animal host interaction to the project. [unreadable] [unreadable]..
  55. Modulation of Electrogenic Sodium Bicarbonate Transport
    Ira Kurtz; Fiscal Year: 2007
    ..Successful completion of this project will enhance our understanding of the mechanisms responsible for regulating H+/base transporters. ..
    Ah Lim Tsai; Fiscal Year: 2008
    ..The last aim will provide direct data on the membrane topology of PGHS and the mechanism of its substrate presentation and product release. [unreadable] [unreadable]..
  57. Magnetic Circular Dichroism/Circular Discroism System
    Ah Lim Tsai; Fiscal Year: 2008
    ..To guarantee a reliable MCD/CD facility for ongoing research and training purposes, we chose to buy JASCO spectrometers for their versatile performance, durability and ease of use. [unreadable] [unreadable] [unreadable]..
  58. GDF Modulation of Tendon Maintenance and Repair
    Borjana Mikic; Fiscal Year: 2008
    ..These studies combine to enhance our understanding of the mechanisms of action of GDFs in tendon maintenance and repair. ..
  59. BH3-only protein BNIP3 in tumor progression
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  60. A High-Throughput Assay for Influenza Replicase/RNA Polymerase Inhibitors
    ROBERT KUCHTA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  61. Regulation & Function of Calponin
    Jian Ping Jin; Fiscal Year: 2010
    ..The results will provide new insights into many important physiological and pathological processes, such as cell proliferation, cell migration, wound healing, myogenesis, lung alveolar mechanics, and tumor metastasis. ..
  62. Accelerating metabolic discovery using characterization data
    Timothy Lilburn; Fiscal Year: 2007
    ..The fight against well-known pathogens and biothreat agents, as well as against new, emerging pathogens will be greatly aided by these tools. [unreadable] [unreadable] [unreadable] [unreadable]..
  63. Gut Hormones/Other Circulatory Regulators of Appetite
    Stephen Bloom; Fiscal Year: 2006
    ..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..