gene duplication

Summary

Summary: Processes occurring in various organisms by which new genes arise, i.e. the duplication of a single gene. In contiguous gene duplication, the duplicated sequence coexists within the boundaries set by the start and stop signals for protein synthesis of the original, resulting in a larger transcription product and protein at the expense of the preexisting protein. In discrete gene duplication, the duplicated sequence is outside the start and stop signals, resulting in two independent genes (GENES, DUPLICATE) and gene products. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Top Publications

  1. ncbi The Sorghum bicolor genome and the diversification of grasses
    Andrew H Paterson
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Nature 457:551-6. 2009
  2. ncbi The evolution of gene duplications: classifying and distinguishing between models
    Hideki Innan
    Graduate University for Advanced Studies, Hayama, Kanagawa 240 0193, Japan
    Nat Rev Genet 11:97-108. 2010
  3. ncbi EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
    Albert J Vilella
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 19:327-35. 2009
  4. ncbi Comparative analysis of the receptor-like kinase family in Arabidopsis and rice
    Shin Han Shiu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Plant Cell 16:1220-34. 2004
  5. ncbi RNA-based gene duplication: mechanistic and evolutionary insights
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015 Lausanne, Switzerland
    Nat Rev Genet 10:19-31. 2009
  6. ncbi The evolutionary fate and consequences of duplicate genes
    M Lynch
    Department of Biology, University of Oregon, Eugene, OR 97403, USA
    Science 290:1151-5. 2000
  7. ncbi The evolutionary significance of ancient genome duplications
    Yves Van de Peer
    Department of Plant Systems Biology, VIB Flanders Institute of Biotechnology, Ghent, Belgium
    Nat Rev Genet 10:725-32. 2009
  8. ncbi The flowering world: a tale of duplications
    Yves Van de Peer
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, 9052 Gent, Belgium
    Trends Plant Sci 14:680-8. 2009
  9. ncbi The origins of genome complexity
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 302:1401-4. 2003
  10. ncbi How confident can we be that orthologs are similar, but paralogs differ?
    Romain A Studer
    Department of Ecology and Evolution, Biophore, Lausanne University, CH 1015 Lausanne, Switzerland and Swiss Institute of Bioinformatics, CH 1015 Lausanne, Switzerland
    Trends Genet 25:210-6. 2009

Research Grants

  1. Structure-Function Analysis of Leishmania MIT
    Andreas Seyfang; Fiscal Year: 2006
  2. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Ake Lernmark; Fiscal Year: 1992
  3. Molecular genetics of Pelizaeus-Merzbacher disease
    Grace M Hobson; Fiscal Year: 2010
  4. Molecular genetics of Pelizaeus-Merzbacher disease
    Grace Hobson; Fiscal Year: 2009
  5. Functional genomic approaches to duplicate gene evolution
    Jianzhi Zhang; Fiscal Year: 2010
  6. Functional genomic approaches to duplicate gene evolution
    Jianzhi Zhang; Fiscal Year: 2010
  7. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2001
  8. Proteomic methodologies for polyketide biosynthesis (RMI)
    MICHAEL BURKART; Fiscal Year: 2007
  9. Statistical Studies of Genomic Evolution
    Masatoshi Nei; Fiscal Year: 2009
  10. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005

Detail Information

Publications228 found, 100 shown here

  1. ncbi The Sorghum bicolor genome and the diversification of grasses
    Andrew H Paterson
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Nature 457:551-6. 2009
    ..About 24% of genes are grass-specific and 7% are sorghum-specific. Recent gene and microRNA duplications may contribute to sorghum's drought tolerance...
  2. ncbi The evolution of gene duplications: classifying and distinguishing between models
    Hideki Innan
    Graduate University for Advanced Studies, Hayama, Kanagawa 240 0193, Japan
    Nat Rev Genet 11:97-108. 2010
    ..Setting out these predictions is an important step towards identifying the main mechanisms that are involved in the evolution of gene duplications...
  3. ncbi EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates
    Albert J Vilella
    EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 19:327-35. 2009
    ..All data are made available in a number of formats and will be kept up to date with the Ensembl project...
  4. ncbi Comparative analysis of the receptor-like kinase family in Arabidopsis and rice
    Shin Han Shiu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Plant Cell 16:1220-34. 2004
    ..These findings led us to hypothesize that most of the recent expansions of the RLK/Pelle family have involved defense/resistance-related genes...
  5. ncbi RNA-based gene duplication: mechanistic and evolutionary insights
    Henrik Kaessmann
    Center for Integrative Genomics, University of Lausanne, Genopode, CH 1015 Lausanne, Switzerland
    Nat Rev Genet 10:19-31. 2009
    ..For example, analyses of chromosomal gene movement patterns via RNA-based gene duplication have shed fresh light on the evolutionary origin and biology of our sex chromosomes.
  6. ncbi The evolutionary fate and consequences of duplicate genes
    M Lynch
    Department of Biology, University of Oregon, Eugene, OR 97403, USA
    Science 290:1151-5. 2000
    b>Gene duplication has generally been viewed as a necessary source of material for the origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how frequently they evolve new functions...
  7. ncbi The evolutionary significance of ancient genome duplications
    Yves Van de Peer
    Department of Plant Systems Biology, VIB Flanders Institute of Biotechnology, Ghent, Belgium
    Nat Rev Genet 10:725-32. 2009
    ....
  8. ncbi The flowering world: a tale of duplications
    Yves Van de Peer
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, 9052 Gent, Belgium
    Trends Plant Sci 14:680-8. 2009
    ..This is important if we want to demonstrate the significance of genome duplications for the evolution and radiation of (different groups of) flowering plants...
  9. ncbi The origins of genome complexity
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 302:1401-4. 2003
    ..The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies...
  10. ncbi How confident can we be that orthologs are similar, but paralogs differ?
    Romain A Studer
    Department of Ecology and Evolution, Biophore, Lausanne University, CH 1015 Lausanne, Switzerland and Swiss Institute of Bioinformatics, CH 1015 Lausanne, Switzerland
    Trends Genet 25:210-6. 2009
    ..Thus, functional change between orthologs might be as common as between paralogs, and future studies should be designed to test the impact of duplication against this alternative model...
  11. ncbi Divergent evolution of duplicate genes leads to genetic incompatibilities within A. thaliana
    David Bikard
    Genetics and Plant Breeding, INRA, SGAP UR254, F 78026 Versailles, France
    Science 323:623-6. 2009
    ..Our data suggest that these passive mechanisms, gene duplication and extinction, could represent an important source of genetic incompatibilities across all taxa.
  12. ncbi Strong association of de novo copy number mutations with autism
    Jonathan Sebat
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 316:445-9. 2007
    ..Affected genomic regions were highly heterogeneous and included mutations of single genes. These findings establish de novo germline mutation as a more significant risk factor for ASD than previously recognized...
  13. ncbi Importance of lineage-specific expansion of plant tandem duplicates in the adaptive response to environmental stimuli
    Kousuke Hanada
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA
    Plant Physiol 148:993-1003. 2008
    Plants have substantially higher gene duplication rates compared with most other eukaryotes. These plant gene duplicates are mostly derived from whole genome and/or tandem duplications...
  14. ncbi Distinguishing among evolutionary models for the maintenance of gene duplicates
    Matthew W Hahn
    Department of Biology and School of Informatics, Indiana University, Bloomington, IN 47405, USA
    J Hered 100:605-17. 2009
    ..Though the various outcomes of gene duplication are often strictly associated with the presence or absence of adaptive natural selection, I argue that ..
  15. ncbi The amphioxus genome and the evolution of the chordate karyotype
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Nature 453:1064-71. 2008
    ..These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution...
  16. ncbi DAGchainer: a tool for mining segmental genome duplications and synteny
    Brian J Haas
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Bioinformatics 20:3643-6. 2004
    ..Automated mining of the Arabidopsis genome for segmental duplications illustrates the use of DAGchainer...
  17. ncbi The genome of black cottonwood, Populus trichocarpa (Torr. & Gray)
    G A Tuskan
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Science 313:1596-604. 2006
    ..Nucleotide substitution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantially more slowly in Populus than in ..
  18. ncbi Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication
    Angèle Tingaud-Sequeira
    Laboratory of Institut de Recerca i Tecnologia Agroalimentàries Institut de Ciències del Mar, Consejo Superior de Investigaciones Cientificas, 08003 Barcelona, Spain
    BMC Evol Biol 8:259. 2008
    ..However, teleosts have an additional AQP isoform structurally more similar to AQP1, though its relationship with AQP1o is unclear...
  19. ncbi The probability of duplicate gene preservation by subfunctionalization
    M Lynch
    Department of Biology, University of Oregon, Eugene, Oregon 97403, USA
    Genetics 154:459-73. 2000
    ....
  20. ncbi Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after?
    Shigehiro Kuraku
    Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
    Mol Biol Evol 26:47-59. 2009
    ..Apart from subsequent lineage-specific modifications, these ancient genome duplication events might serve generally to distinguish vertebrates from invertebrates at the genomic level...
  21. ncbi Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
    Jean-Marc Aury
    Genoscope and CNRS UMR 8030, , 91057 Evry, France
    Nature 444:171-8. 2006
    ..The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints...
  22. ncbi Gene co-option in physiological and morphological evolution
    John R True
    Department of Ecology and Evolution, State University of New York at Stony Brook, 11794 5245, USA
    Annu Rev Cell Dev Biol 18:53-80. 2002
    ..This often involves gene duplication followed by specialization of the resulting paralogous genes into particular functions...
  23. ncbi Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
    ..Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity...
  24. ncbi The origins and impact of primate segmental duplications
    Tomas Marques-Bonet
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Trends Genet 25:443-54. 2009
    ..Although many genomes will be sequenced in the future, resolution of this aspect of genomic architecture still requires high quality sequences and detailed analyses...
  25. ncbi Automatic genome-wide reconstruction of phylogenetic gene trees
    Ilan Wapinski
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Bioinformatics 23:i549-58. 2007
    b>Gene duplication and divergence is a major evolutionary force. Despite the growing number of fully sequenced genomes, methods for investigating these events on a genome-wide scale are still in their infancy...
  26. ncbi Maintenance of duplicate genes and their functional redundancy by reduced expression
    Wenfeng Qian
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Trends Genet 26:425-30. 2010
    ..Whereas the majority of the expression reductions are likely to be neutral, some are apparently beneficial to rebalancing gene dosage after duplication...
  27. ncbi PLP1 gene duplication causes overexpression and alteration of the PLP/DM20 splicing balance in fibroblasts from Pelizaeus-Merzbacher disease patients
    Stefano Regis
    Laboratorio Diagnosi Pre Postnatale Malattie Metaboliche, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Biochim Biophys Acta 1792:548-54. 2009
    ..expression, we analysed the PLP/DM20 expression profile in fibroblasts from three PMD patients with a PLP1 gene duplication. Gene expression was evaluated by real-time PCR using two different PLP1 amplicons and two different ..
  28. ncbi Evolution by leaps: gene duplication in bacteria
    Margrethe H Serres
    Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Biol Direct 4:46. 2009
    ..The presence of families and superfamilies of proteins suggest a history of gene duplication and divergence during evolution...
  29. ncbi Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 18:1944-54. 2008
    ..Comparative analysis of inferred homologous genes derived from this model shows patterns of preferential gene retention or loss after polyploidy and reveals large variability of nucleotide substitution rates among plant nuclear genomes...
  30. ncbi APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    Anne Rovelet-Lecrux
    Inserm U614 IFRMP, Faculty of Medicine, Rouen, France
    Nat Genet 38:24-6. 2006
    ..37 Mb. Brains from individuals with APP duplication showed abundant parenchymal and vascular deposits of amyloid-beta peptides. Duplication of the APP locus, resulting in accumulation of amyloid-beta peptides, causes ADEOAD with CAA...
  31. ncbi Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
    Idoya Lahortiga
    Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie VIB, Leuven, Belgium
    Nat Genet 39:593-5. 2007
    ..Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL...
  32. ncbi Gene duplication and evolutionary novelty in plants
    Lex E Flagel
    Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011, USA
    New Phytol 183:557-64. 2009
    ..This has led many researchers to speculate that gene duplication may have played an important role in the evolution of phenotypic novelty within plants...
  33. ncbi Preferential regulation of duplicated genes by microRNAs in mammals
    Jingjing Li
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Genome Biol 9:R132. 2008
    ..Specifically, while mammalian paralogs are known to overcome their initial complete functional redundancy through variation in regulation and expression, the potential involvement of microRNAs in this process has not been investigated...
  34. ncbi Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities
    Zhongyou Li
    Department of Cancer Genetics and Center for Genetics and Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Hum Mol Genet 16:1359-66. 2007
    ..This new mouse model represents a powerful tool to further understand the molecular and cellular mechanisms of Down syndrome...
  35. ncbi Simultaneous Bayesian gene tree reconstruction and reconciliation analysis
    Orjan Akerborg
    School for Computer Science and Communication, Royal Institute of Technology, SE 10044 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:5714-9. 2009
    We present GSR, a probabilistic model integrating gene duplication, sequence evolution, and a relaxed molecular clock for substitution rates, that enables genomewide analysis of gene families...
  36. ncbi Unravelling angiosperm genome evolution by phylogenetic analysis of chromosomal duplication events
    John E Bowers
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Nature 422:433-8. 2003
    ....
  37. ncbi Complexity, connectivity, and duplicability as barriers to lateral gene transfer
    Alon Wellner
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, 69978
    Genome Biol 8:R156. 2007
    ....
  38. ncbi Adaptive evolution of young gene duplicates in mammals
    Mira V Han
    School of Informatics, Indiana University, Bloomington, IN 47405, USA
    Genome Res 19:859-67. 2009
    ..The results are also in agreement with the classical model of evolution by gene duplication, supporting a common role for neofunctionalization in the long-term maintenance of gene duplicates.
  39. ncbi Relaxation of yeast mitochondrial functions after whole-genome duplication
    Huifeng Jiang
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    Genome Res 18:1466-71. 2008
    ..This new energy production strategy could have led to the relaxation of mitochondrial function in the relevant yeast species...
  40. ncbi Comparison of pig, sheep and chicken SCD5 homologs: Evidence for an early gene duplication event
    Andrea J Lengi
    Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Comp Biochem Physiol B Biochem Mol Biol 150:440-6. 2008
    ..This is the first report of an SCD5 homolog in a non-mammalian species, and suggests that SCD5 may be the result of an early gene duplication event that occurred before the divergence of mammals.
  41. ncbi Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
    ....
  42. ncbi Gene duplication and adaptive evolution of digestive proteases in Drosophila arizonae female reproductive tracts
    Erin S Kelleher
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 3:e148. 2007
    ..Additionally, pervasive gene duplication, adaptive evolution, and rapid acquisition of a novel digestive function by the female reproductive tract ..
  43. ncbi Synteny and collinearity in plant genomes
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA
    Science 320:486-8. 2008
    ..Because of variability in DNA substitution rates among taxa and genes, deviation from collinearity might be a more reliable phylogenetic character...
  44. ncbi Metabolic adaptation after whole genome duplication
    Milan J A van Hoek
    Theoretical Biology Bioinformatics Group, Utrecht University, Utrecht, The Netherlands
    Mol Biol Evol 26:2441-53. 2009
    ..This explains why WGD, while pivotal in the evolution of many lineages and an apparent "easy" genetic operator, occurs relatively rarely...
  45. ncbi Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts
    Erin S Kelleher
    Department of Ecology and Evolutionary Biology, University of Arizona, USA
    Mol Biol Evol 26:2125-34. 2009
    ..tract proteins in the cactophilic fruit fly Drosophila arizonae, identified pervasive, lineage-specific gene duplication amongst secreted proteases...
  46. ncbi InParanoid 6: eukaryotic ortholog clusters with inparalogs
    Ann Charlotte Berglund
    Linnaeus Centre for Bioinformatics, Uppsala University, BMC Box 598, 75124, Uppsala, Sweden
    Nucleic Acids Res 36:D263-6. 2008
    ..A new InParanoid website has been developed which is optimized for speed both for users and for updating the system. The XML output format has been improved for efficient processing of the InParanoid ortholog clusters...
  47. ncbi Comparative analysis indicates regulatory neofunctionalization of yeast duplicates
    Itay Tirosh
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Genome Biol 8:R50. 2007
    b>Gene duplication provides raw material for the generation of new functions, but most duplicates are rapidly lost due to the initial redundancy in gene function. How gene function diversifies following duplication is largely unclear...
  48. ncbi Characterization, polymorphism, and evolution of MHC class II B genes in birds of prey
    Miguel Alcaide
    Estacion Biologica de Donana, CSIC Pabellón de Perú, Avda Ma Luisa s n, 41013, Sevilla, Spain
    J Mol Evol 65:541-54. 2007
    ..Finally, through interlocus comparisons and phylogenetic analysis, we also discuss genetic evidence for concerted and transspecies evolution in the raptor MHC...
  49. ncbi OPTIC: orthologous and paralogous transcripts in clades
    Andreas Heger
    Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK
    Nucleic Acids Res 36:D267-70. 2008
    ..Gene predictions, multiple alignments and phylogenetic trees are freely available to browse and download from http://genserv.anat.ox.ac.uk/clades. Further genomes and clades will be added in the future...
  50. ncbi Identifying concerted evolution and gene conversion in mammalian gene pairs lasting over 100 million years
    Andrew R Carson
    The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Evol Biol 9:156. 2009
    ..To eliminate genes that have been conserved due to strong purifying selection, our analysis also required at least one intron to have retained high sequence similarity between paralogues...
  51. ncbi Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression
    Stephanie Bertrand
    Molecular Zoology, Institut de Génomique Fonctionelle de Lyon UMR 5242 du CNRS, INRA, IFR128 Biosciences Lyon Gerland, Universite de Lyon, UCB Ecole Normale Supérieure de Lyon, France
    PLoS Genet 3:e188. 2007
    ..Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily...
  52. ncbi A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX, 77030, USA
    Cell 131:1235-47. 2007
    ..We propose that complex duplication and deletion rearrangements associated with PMD, and potentially other nonrecurrent rearrangements, may be explained by this replication-based mechanism...
  53. ncbi Positive selection of a duplicated UV-sensitive visual pigment coincides with wing pigment evolution in Heliconius butterflies
    Adriana D Briscoe
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:3628-33. 2010
    ..Functional diversification of the UV-sensitive visual pigments may help explain why the yellow wing pigments of Heliconius are so colorful in the UV range compared to the yellow pigments of close relatives lacking the UV opsin duplicate...
  54. ncbi The avian Toll-Like receptor pathway--subtle differences amidst general conformity
    Paul Cormican
    School of Biochemistry and Immunology, Trinity College, University of Dublin, Dublin 2, Ireland
    Dev Comp Immunol 33:967-73. 2009
    ..The TLR receptors show a pattern of gene duplication and gene loss in both avian species when compared to mammals...
  55. ncbi The complex relationship of gene duplication and essentiality
    Takashi Makino
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland
    Trends Genet 25:152-5. 2009
    ..We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were ..
  56. ncbi Evidence and evolutionary analysis of ancient whole-genome duplication in barley predating the divergence from rice
    Thomas Thiel
    IPK Gatersleben, Corrensstr, 3, 06466 Gatersleben, Germany
    BMC Evol Biol 9:209. 2009
    ....
  57. ncbi The resolution of sexual antagonism by gene duplication
    Tim Connallon
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 187:919-37. 2011
    ..Recent verbal models suggest that gene duplication and sex-specific cooption of paralogs might resolve sexual antagonism and facilitate evolutionary divergence ..
  58. ncbi Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes
    Jike Cui
    Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, Massachusetts, USA
    PLoS Negl Trop Dis 4:e782. 2010
    ..With the goal of beginning to understand why some Trichomonas genes are present in so many copies, we characterized here a family of approximately 123 Trichomonas genes that encode transmembrane adenylyl cyclases (TMACs)...
  59. ncbi Genome-wide comparative analysis of the Brassica rapa gene space reveals genome shrinkage and differential loss of duplicated genes after whole genome triplication
    Jeong Hwan Mun
    Department of Agricultural Biotechnology, National Academy of Agricultural Science, Rural Development Administration, 150 Suin ro, Gwonseon gu, Suwon 441 707, Korea
    Genome Biol 10:R111. 2009
    ..rapa, which is a strong challenge of structural and comparative crop genomics...
  60. ncbi Transcript profiling provides evidence of functional divergence and expression networks among ribosomal protein gene paralogs in Brassica napus
    Carrie A Whittle
    Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Canada S7N 0W9
    Plant Cell 21:2203-19. 2009
    ....
  61. ncbi Protein-coding genes are epigenetically regulated in Arabidopsis polyploids
    H S Lee
    Genetics Program and Department of Soil and Crop Sciences, Texas A and M University, College Station, TX 77843-2474, USA
    Proc Natl Acad Sci U S A 98:6753-8. 2001
    ..Compared with classic genetic mutations, epigenetic regulation may be advantageous for selection and adaptation of polyploid species during evolution and development...
  62. ncbi Rapid diversification of cell signaling phenotypes by modular domain recombination
    Sergio G Peisajovich
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 328:368-72. 2010
    ..Thus, novel linkages between preexisting domains may have a major role in the evolution of protein networks and novel phenotypic behaviors...
  63. ncbi A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection
    Melany Jackson
    John Hughes Bennett Laboratory, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU, UK
    BMC Genomics 7:212. 2006
    ..The rodent specific reproductive homeobox (Rhox) gene cluster on the X chromosome has been reported to contain twelve homeobox-containing genes, Rhox1-12...
  64. ncbi Genomic analysis of Hox clusters in the sea lamprey Petromyzon marinus
    Steven Q Irvine
    Yale University, Department of Molecular, Cellular and Developmental Biology, New Haven, Connecticut 06520-8103, USA
    J Exp Zool 294:47-62. 2002
    ..marinus has a total of either three or four Hox clusters. We also identify four highly conserved non-coding sequence motifs shared with higher vertebrates in a genomic comparison of Hox 10 genes...
  65. ncbi Doubly uniparental inheritance is associated with high polymorphism for rearranged and recombinant control region haplotypes in Baltic Mytilus trossulus
    Artur Burzynski
    Polish Academy of Sciences, Institute of Oceanology, Department of Genetics and Mariene Biotechnology, Sopot, Poland
    Genetics 174:1081-94. 2006
    ..The data are also considered in relation to the hypothesis that the M. edulis M-like control region sequence is necessary to confer the paternal role on genomes that are otherwise F-like...
  66. ncbi Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis...
  67. ncbi Molecular evolution of the HoxA cluster in the three major gnathostome lineages
    Chi hua Chiu
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:5492-7. 2002
    ..as predicted by the duplication-degeneration-complementation model in which genetic redundancy after gene duplication is resolved because of the fixation of complementary degenerative mutations...
  68. ncbi The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes
    Santhosh Karanth
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    FEBS J 275:3031-40. 2008
    ....
  69. ncbi Expansion and molecular evolution of the interferon-induced 2'-5' oligoadenylate synthetase gene family
    S Kumar
    Department of Biology and Molecular and Cellular Biology Program, Arizona State University, Tempe 85287 1501, USA
    Mol Biol Evol 17:738-50. 2000
    ..The modern mammalian 2'-5'OAS genes underwent successive gene duplication events resulting in three size classes of enzymes, containing one, two, or three homologous domains...
  70. ncbi The evolution of hexapod engrailed-family genes: evidence for conservation and concerted evolution
    Andrew D Peel
    Laboratory for Development and Evolution, Department of Zoology, University Museum of Zoology, Cambridge, UK
    Proc Biol Sci 273:1733-42. 2006
    ..paralogues are evolving in a concerted fashion, resulting in gene trees that overestimate the frequency of gene duplication. We present new phylogenetic analyses using non-homeodomain amino acid sequence that support this view. The S...
  71. ncbi The laccase multi-gene family in Coprinopsis cinerea has seventeen different members that divide into two distinct subfamilies
    Sreedhar Kilaru
    Molecular Wood Biotechnology, Institute of Forest Botany, , Germany
    Curr Genet 50:45-60. 2006
    ..divides in the phylogenetic tree of deduced proteins into smaller clusters that probably reflect recent gene duplication events...
  72. ncbi The evolution of the novel Sdic gene cluster in Drosophila melanogaster
    Rita Ponce
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Gene 376:174-83. 2006
    ..There is also a retrotransposon located at the 3' end of each Sdic gene copy. We argue that this gene cluster was formed in the last two million years by at least three tandem duplications and one retrotransposition event...
  73. ncbi Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family
    Ming Wei Kuo
    Institute of Molecular Biology, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei, 115, Taiwan
    Biochem J 389:19-26. 2005
    ..Thus we have characterized the phylogenetic relationships, expression patterns and chromosomal locations of these Ftz-F1 genes, and have demonstrated their identities as NR5A genes in relation to the orthologous genes in other species...
  74. ncbi Roles of diversifying selection and coordinated evolution in the evolution of amphibian antimicrobial peptides
    Thomas F Duda
    Naos Marine Lab, Smithsonian Tropical Research Institute, Balboa, Ancon, Republic of Panama
    Mol Biol Evol 19:858-64. 2002
    ....
  75. ncbi Evolution of the vertebrate ABC gene family: analysis of gene birth and death
    Tarmo Annilo
    Laboratory of Genomic Diversity, Building 560, Room 21-18, NCI-Frederick, Frederick, MD 21702, USA
    Genomics 88:1-11. 2006
    ..Multiple gene duplication and deletion events were identified in different lineages, indicating an ongoing process of gene evolution...
  76. ncbi Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid
    Ying-Ying Han
    State Key Laboratory of Genetic Engineering, Research Centre of Gene Diversity and Designed Agriculture, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, School of Life Science, Fudan University, Shanghai, China
    Genetica 128:429-38. 2006
    Plant genomes appear to exploit the process of gene duplication as a primary means of acquiring biochemical and developmental flexibility. The best example is the gene encoding chalcone synthase (CHS, EC2.3.1...
  77. ncbi Sequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitism
    Charles H Opperman
    Center for the Biology of Nematode Parasitism, Department of Plant Pathology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 105:14802-7. 2008
    ..This sequence and map represent a wealth of biological information on both the nature of nematode parasitism of plants and its evolution...
  78. ncbi Extensive lineage-specific gene duplication and evolution of the spiggin multi-gene family in stickleback
    Ryouka Kawahara
    Ocean Research Institute, University of Tokyo, 1 15 1 Minamidai, Nakano Ku, Tokyo 164 8639, Japan
    BMC Evol Biol 7:209. 2007
    ..Although recent studies reported multiple occurrences of genes that encode this glue-like protein spiggin in threespine and ninespine sticklebacks, it is still unclear how many genes compose the spiggin multi-gene family...
  79. ncbi Origins of the many NPY-family receptors in mammals
    D Larhammar
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, Box 593, S 75124, Uppsala, Sweden
    Peptides 22:295-307. 2001
    ..The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat...
  80. ncbi Gene duplication and the evolution of vertebrate skeletal mineralization
    Kazuhiko Kawasaki
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Cells Tissues Organs 186:7-24. 2007
    ..Then both before and after the split of ray-finned fish and lobe-finned fish, tandem gene duplication created two types of SCPP genes, each residing on the opposite side of SPARCL1...
  81. ncbi The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number
    K Vanhalst
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology (VIB, Ghent University, Ledeganckstraat 35, B-9000, Ghent, Belgium
    FEBS Lett 495:120-5. 2001
    ..The complex relationship between human and mouse genes and the lack of pseudogenes in the mouse protocadherin-beta gene cluster suggest a species-specific evolutionary pressure for maintenance of numerous protocadherin-beta genes...
  82. ncbi Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five?
    B R Bettencourt
    Department of Organismal Biology and Anatomy, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 18:1272-82. 2001
    ..The proliferation, concerted evolution, and maintenance of functionality in the D. melanogaster hsp70 genes is consistent with the action of natural selection in this species...
  83. ncbi Isolation and characterization of the pea cytochrome c oxidase Vb gene
    Nakao Kubo
    Graduate School of Agriculture, Kyoto Prefectural University, Kyoto Prefectural Institute of Agricultural Biotechnology, 74 Oji, Kitainayazuma, Seika, Soraku, Kyoto 619 0244, Japan
    Genome 49:1481-9. 2006
    ..A phylogenetic analysis of coxVb suggests the occurrence of gene duplication events during angiosperm evolution...
  84. ncbi Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution
    R O Morgan
    Faculty of Medicine, University of Oviedo, Oviedo, E 33006, Spain
    Genomics 60:40-9. 1999
    ....
  85. ncbi Phylogeny and regulation of four lipocalin genes clustered in the chicken genome: evidence of a functional diversification after gene duplication
    Aldo Pagano
    Dipartimento di Oncologia, Biologia e Genetica, , 16132 Genoa, Italy
    Gene 331:95-106. 2004
    ....
  86. ncbi Human subtelomeric WASH genes encode a new subclass of the WASP family
    Elena V Linardopoulou
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Genet 3:e237. 2007
    ..Thus, human subtelomeres are not genetic junkyards, and WASH's location in these dynamic regions could have advantageous as well as pathologic consequences...
  87. ncbi Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice
    Dong Wang
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, PR China
    BMC Genomics 9:44. 2008
    ..They have been known to play important roles in RNA processing as RNA-binding proteins in animals. To date, few plant CCCH proteins have been studied functionally...
  88. ncbi The six hyaluronidase-like genes in the human and mouse genomes
    A B Csoka
    Department of Pathology, School of Medicine, University of California San Francisco, LR 101, 4 Koret Way, San Francisco, CA 94143 0506, USA
    Matrix Biol 20:499-508. 2001
    ..3. The extensive homology between the different hyaluronidase genes suggests ancient gene duplication, followed by en masse block duplication, events that occurred before the emergence of modern mammals...
  89. ncbi Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues
    C E Warren
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Glycobiology 11:979-88. 2001
    ..Nevertheless, the nematode has evolved six diverged core 2 GlcNAc-T-like genes, and we postulate that these arose in response to selection pressures to which C. elegans is not ordinarily subjected in the laboratory...
  90. ncbi Mechanisms and rates of birth and death of dispersed duplicated genes during the evolution of a multigene family in diploid and tetraploid wheats
    Eduard D Akhunov
    Department of Plant Sciences, University of California, Davis, USA
    Mol Biol Evol 24:539-50. 2007
    ..It is shown that dispersed gene duplication rate consists of the primary rate (duplications of ancestral genes) and the secondary rate (duplications of ..
  91. ncbi Analysis of the genomic structure of the porcine CD1 gene cluster
    Tomoko Eguchi-Ogawa
    Animal Genome Research Program, National Institute of Agrobiological Sciences, 2 1 2 Kannondai, Tsukuba, Ibaraki 305 8602, Japan
    Genomics 89:248-61. 2007
    ..This analysis of the genomic sequence of the porcine CD1 family will contribute to our understanding of the evolution of mammalian CD1 genes...
  92. ncbi Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolution
    Hector Escriva
    CNRS UMR 5665, , , Lyon Cedex, France
    Mol Biol Evol 19:1440-50. 2002
    ..analysis of 33 selected gene families, dispersed through the whole genome, revealed that one period of gene duplication arose before the lamprey-gnathostome split and this was followed by a second period of gene duplication after ..
  93. ncbi Characterization of Hox genes in the bichir, Polypterus palmas
    Christina Ledje
    Department of Genetics, University of Lund, SE-223 62 Lund, Sweden
    J Exp Zool 294:107-11. 2002
    ..The greater number of Hox clusters in the teleosts suggests that Hox gene duplication events have occurred during the radiation of ray-finned fishes...
  94. ncbi Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome
    Felipe Karam Teixeira
    , , UFRJ, 21944-970 Rio de Janeiro, Brasil
    J Mol Evol 59:761-70. 2004
    ..A molecular evolutionary pathway, in which cytosolic and peroxisomal isoforms diverged early from chloroplastic ones, is proposed...
  95. ncbi Analysis of the human VPS13 gene family
    Antonio Velayos-Baeza
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, OX3 7BN Oxford, UK
    Genomics 84:536-49. 2004
    ..Protein sequence comparisons suggest that intramolecular duplications have played an important role in the evolution of this gene family...
  96. ncbi The Dlx gene complement of the leopard shark, Triakis semifasciata, resembles that of mammals: implications for genomic and morphological evolution of jawed vertebrates
    David W Stock
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309 0334, USA
    Genetics 169:807-17. 2005
    Extensive gene duplication is thought to have occurred in the vertebrate lineage after it diverged from cephalochordates and before the divergence of lobe- and ray-finned fishes, but the exact timing remains obscure...
  97. ncbi Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fish
    Simone Hoegg
    Department of Biology, University of Konstanz, 78457 Konstanz, Germany
    J Mol Evol 59:190-203. 2004
    ..The additional number of genes resulting from this event might have facilitated the evolutionary radiation and the phenotypic diversification of the teleost fish...
  98. ncbi Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Room A 1302 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA
    Gene 339:49-59. 2004
    ..The presence and conservation of a cluster of five genes encoding epididymal lipocalins, differently regulated and regionalized in the epididymis, strongly suggests that these proteins may play an important role for male fertility...
  99. ncbi Continued colonization of the human genome by mitochondrial DNA
    Miria Ricchetti
    Unité de Génétique Moléculaire des Levures UFR 927 Univ P et M Curie and URA 2171 CNRS, Department of Structure and Dynamics of Genomes, Institut Pasteur, Paris, France
    PLoS Biol 2:E273. 2004
    ....
  100. ncbi The evolutionary implications of knox-I gene duplications in conifers: correlated evidence from phylogeny, gene mapping, and analysis of functional divergence
    Carine Guillet-Claude
    , , , Sainte-Foy, , Canada
    Mol Biol Evol 21:2232-45. 2004
    ..The implications of the correlation between phylogenetic, structural, and functional information are discussed in relation to the diversification of the knox-I gene family in conifers...
  101. ncbi A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins
    Yanjing Xiao
    Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA
    BMC Genomics 5:56. 2004
    ..However, the evolutionary relationships among these five groups of defensins remain controversial...

Research Grants84

  1. Structure-Function Analysis of Leishmania MIT
    Andreas Seyfang; Fiscal Year: 2006
    ..superfamily of membrane transporters with 12 transmembrane domains that are thought to have evolved through gene duplication of an ancestral 6-transmembranedomain transporter...
  2. ISLET CELL MEMBRANE ANTIBODIES IN DIABETES
    Ake Lernmark; Fiscal Year: 1992
    ..isoforms important in several autoimmune diseases, including Stiff-Man syndrome, may be explained in part by gene duplication. We confirm the mapping of GAD1 (3...
  3. Molecular genetics of Pelizaeus-Merzbacher disease
    Grace M Hobson; Fiscal Year: 2010
    ..Motor milestones and speech are also delayed in most patients. Neither the molecular mechanisms of gene duplication nor the molecular basis for the clinical phenotype in PMD is well understood...
  4. Molecular genetics of Pelizaeus-Merzbacher disease
    Grace Hobson; Fiscal Year: 2009
    ..Motor milestones and speech are also delayed in most patients. Neither the molecular mechanisms of gene duplication nor the molecular basis for the clinical phenotype in PMD is well understood...
  5. Functional genomic approaches to duplicate gene evolution
    Jianzhi Zhang; Fiscal Year: 2010
    ..b>Gene duplication is wildly regarded as the primary source of new genes, but the general patterns and mechanisms of functional ..
  6. Functional genomic approaches to duplicate gene evolution
    Jianzhi Zhang; Fiscal Year: 2010
    ..b>Gene duplication is wildly regarded as the primary source of new genes, but the general patterns and mechanisms of functional ..
  7. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2001
    ..will show how new biomolecular function is created in higher organisms, by mutation, insertion, deletion gene duplication and recruitment of duplicate genes...
  8. Proteomic methodologies for polyketide biosynthesis (RMI)
    MICHAEL BURKART; Fiscal Year: 2007
    ..to characterize genetically due to the fact that the large nuclear genomes of dinoflagellates contain high gene duplication with multiple intron content...
  9. Statistical Studies of Genomic Evolution
    Masatoshi Nei; Fiscal Year: 2009
    ..This study is expected to give important information on the molecular mechanism of gene duplication, gene death, inter chromosomal gene transfer, etc...
  10. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005
    ..As a result of a gene duplication early in vertebrate evolution, humans and other vertebrates have another cholinesterase, ..
  11. CELL RECEPTORS IN COAGULATION AND ATHEROGENESIS
    SALVATORE PIZZO; Fiscal Year: 1992
    ..During the course of evolution, gene duplication and divergence occurred so that a family of complement proteins which are alpha2M homologues (C3, C4 and C5) ..
  12. EXPRESSION AND FUNCTION OF CONE PIGMENT GENES
    Jay Neitz; Fiscal Year: 2006
    ..The M and L genes lie in a head-to-tail tandem array on the X-chromosome and were produced by a gene duplication event that is estimated to have occurred in the primate lineage about 35-60 million years ago...
  13. GENE CONVERSION IN MICE
    John Schimenti; Fiscal Year: 1999
    ..The era of molecular biology has dramatically illustrated the role of gene duplication in genome evolution...
  14. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ..immune system evolve more rapidly than those expressed in other tissues; and (6) to understand the roles of gene duplication, interlocus recombination, and natural selection in the diversification of immune system gene families (..
  15. GENETICS AND BIOCHEMISTRY OF A MURINE RETROPOSON
    Sandra Martin; Fiscal Year: 2001
    ..repetitive DNA, provides a substrate for homologous recombination of mispaired sequences, leading to gene duplication, deletion, chromosome translocation and, potentially, exon shuffling...
  16. COMPARATIVE MOLECULAR SEQUENCE ANALYSIS
    Sudhir Kumar; Fiscal Year: 2007
    ..species, and gene families; [ii] estimate the confidence intervals for times of species divergence and gene duplication events; [iii] deduce tracks of adaptive evolution in proteins, genes, and codons; [iv] test alternative ..
  17. COMPARATIVE MOLECULAR SEQUENCE ANALYSIS
    Sudhir Kumar; Fiscal Year: 2009
    ..species, and gene families; [ii] estimate the confidence intervals for times of species divergence and gene duplication events; [iii] deduce tracks of adaptive evolution in proteins, genes, and codons; [iv] test alternative ..
  18. Genetics & Biochemistry of a Murine Retroposon
    Sandra Martin; Fiscal Year: 2005
    ..repetitive DNA, provides a substrate for homologous recombination of mispaired sequences, leading to gene duplication, deletion, chromosome translocation and, potentially, exon shuffling...
  19. IRBP--STRUCTURE/FUNCTION
    Federico Gonzalez Fernandez; Fiscal Year: 2002
    ..It is reasoned that through gene duplication the structure of the modules diverged, creating sites tailored for each of IRBP's physiological ligands...
  20. Characterization of a large protein interaction network
    Andreas Wagner; Fiscal Year: 2005
    ..of this network, and an explanation of its structure in terms of its evolution via interaction turnover and gene duplication. Aim 1 is a global characterization of the yeast protein interaction network (YPIN)...
  21. Phylogenetic Analysis with Complex Genome Rearrangement Events
    Jijun Tang; Fiscal Year: 2009
    ..these problems by: (1) mathematical modeling and theoretical analysis of complex evolutionary events such as gene duplication and loss; (2) algorithm design and implementation for phylogenetics and gene order reconstruction (3) ..
  22. Evolution of Chromosome-specific Low Copy Repeats
    Tamim Shaikh; Fiscal Year: 2005
    Large scale duplication of genetic material is a major force driving the evolution of genetic diversity. Gene duplication and subsequent divergence have been instrumental in the creation of new genes with specialized functional roles, a ..
  23. POPULATION GENETICS OF MOBILE ELEMENTS
    Lynn Jorde; Fiscal Year: 2007
    ..Our understanding of genetic disease will also be enhanced by a better understanding of the role of these elements in DNA repair and in gene duplication and deletion.