protozoan genes

Summary

Summary: The functional hereditary units of PROTOZOA.

Top Publications

  1. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
  2. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
  3. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
  4. ncbi Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
    Lucio H Freitas-Junior
    Institut Pasteur, Biology of Host Parasite Interactions Unit CNRS URA2581, 25, rue du Dr Roux, 75724 Paris, France
    Cell 121:25-36. 2005
  5. ncbi Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania
    Kelly A Robinson
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 128:217-28. 2003
  6. ncbi Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
    Hilary G Morrison
    Marine Biological Laboratory, Woods Hole, MA 02543 1015, USA
    Science 317:1921-6. 2007
  7. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
  8. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
  9. ncbi Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
  10. ncbi Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
    Jean Marc Aury
    Genoscope and CNRS UMR 8030, 2 rue Gaston Crémieux CP5706, 91057 Evry, France
    Nature 444:171-8. 2006

Research Grants

  1. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2010
  2. HYPOTRICH GENOME IN DEVELOPMENT AND EVOLUTION
    David Prescott; Fiscal Year: 2001
  3. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 1999
  4. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
  5. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2005
  6. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2006
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
  8. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2003
  9. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
  10. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007

Detail Information

Publications229 found, 100 shown here

  1. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  2. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria...
  3. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    ..The genome sequence provides a greater understanding of B. bovis metabolism and potential avenues for drug therapies and vaccine development...
  4. ncbi Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
    Lucio H Freitas-Junior
    Institut Pasteur, Biology of Host Parasite Interactions Unit CNRS URA2581, 25, rue du Dr Roux, 75724 Paris, France
    Cell 121:25-36. 2005
    ..Our data demonstrate that mutually exclusive transcription of var genes is linked to the dynamic remodeling of chromatin...
  5. ncbi Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania
    Kelly A Robinson
    Department of Molecular Microbiology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Biochem Parasitol 128:217-28. 2003
    ..The implications to parasite biology, gene amplification, and genetic analysis are discussed...
  6. ncbi Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
    Hilary G Morrison
    Marine Biological Laboratory, Woods Hole, MA 02543 1015, USA
    Science 317:1921-6. 2007
    ..This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite...
  7. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
    ....
  8. pmc Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  9. ncbi Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
    ..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
  10. ncbi Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
    Jean Marc Aury
    Genoscope and CNRS UMR 8030, 2 rue Gaston Crémieux CP5706, 91057 Evry, France
    Nature 444:171-8. 2006
    ..The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints...
  11. ncbi Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum
    Tony Triglia
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Mol Microbiol 55:162-74. 2005
    ..falciparum parasites to utilize alternative receptors on the erythrocyte surface for evasion of receptor polymorphisms and the host immune system...
  12. ncbi Antigenic variation in Babesia bovis occurs through segmental gene conversion of the ves multigene family, within a bidirectional locus of active transcription
    Basima Al-Khedery
    Department of Pathobiology, University of Florida, Gainesville, 32611, USA
    Mol Microbiol 59:402-14. 2006
    ..These results also suggest the possibility of epigenetic regulation through in situ switching among gene loci, further expanding the potential repertoire of variant proteins...
  13. ncbi Protection against Leishmania donovani infection by DNA vaccination: increased DNA vaccination efficiency through inhibiting the cellular p53 response
    A Ghosh
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, H3A 2B4, Quebec, Canada
    Vaccine 19:3169-78. 2001
    ..These results have important implications for DNA vaccination against leishmaniasis and potentially against other infectious diseases...
  14. ncbi Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation
    J E Brownell
    Department of Biology, University of Rochester, New York, 14627, USA
    Cell 84:843-51. 1996
    ..These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histone acetylation is a targeted phenomenon...
  15. pmc A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell
    Tobias Spielmann
    Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston QLD 4029, Australia
    Mol Biol Cell 17:3613-24. 2006
    ..Biochemical and photobleaching studies using these proteins reveal new properties of the parasite-induced membrane compartments in the host cell. This has important implications for the biogenesis and connectivity of these structures...
  16. pmc Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum
    Ron Dzikowski
    Department of Parasitology, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Mol Biol 382:288-97. 2008
    ....
  17. ncbi A phylogenetic comparison of gene trees constructed from plastid, mitochondrial and genomic DNA of Plasmodium species
    D Rathore
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892-0425, USA
    Mol Biochem Parasitol 114:89-94. 2001
    ..falciparum...
  18. pmc The genome of the simian and human malaria parasite Plasmodium knowlesi
    A Pain
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nature 455:799-803. 2008
    ..One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry...
  19. ncbi Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria
    Adama R Trimnell
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Mol Biochem Parasitol 148:169-80. 2006
    ..These studies aid our understanding of the evolutionary mechanisms that shape var diversity and will be important to the development of vaccines against pregnancy associated malaria and severe malaria...
  20. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
    ..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
  21. pmc Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts
    E Ullu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 8056
    Mol Cell Biol 13:720-5. 1993
    ..Thus, trans splicing is cotranscriptional. In addition, we show that trans splicing precedes polyadenylation in the processing of trypanosome tubulin pre-mRNAs...
  22. ncbi Regulation of apicomplexan actin-based motility
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Rev Microbiol 4:621-8. 2006
    ....
  23. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  24. ncbi Expression and function of surface proteins in Trypanosoma brucei
    E Pays
    Department of Molecular Biology, University of Brussels 67, Rhode St Genese, Belgium
    Mol Biochem Parasitol 91:3-36. 1998
  25. ncbi Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum
    Manoj T Duraisingh
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 121:13-24. 2005
    ..Together, this implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum...
  26. pmc PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia
    Céline Baudry
    CNRS FRE 3144, Centre de Genetique Moleculaire, Gif sur Yvette F 91198 Cedex, France
    Genes Dev 23:2478-83. 2009
    ..This is the first in vivo evidence suggesting an essential endonucleolytic function of a domesticated piggyBac transposase...
  27. ncbi Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum
    Joshua B Plotkin
    Harvard Society of Fellows and Bauer Center for Genomics Research, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 428:942-5. 2004
    ..Our method of estimating selective pressures requires far fewer data than comparative sequence analysis, and it measures selection across an entire genome; the method can readily be applied to a large range of sequenced organisms...
  28. ncbi The SRS superfamily of Toxoplasma surface proteins
    Calvin Jung
    Infectious Diseases, Department of Medicine, University of British Columbia, D459 HP East, 2733 Heather Street, Vancouver, BC, Canada V5Z 3J5
    Int J Parasitol 34:285-96. 2004
    ..Orthologous genes are restricted to tissue-dwelling coccidia (Neospora, Sarcocystis) with no related sequences present in other more distant apicomplexa such as Eimeria, Cryptosporidia, and Plasmodium spp...
  29. pmc Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
    ..These results suggest that var genes with DBLalpha1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes with DBLalpha0-like domains promote less virulent malaria infections...
  30. ncbi A sub-family of common and highly conserved Plasmodium falciparum var genes
    Ali Salanti
    Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Mol Biochem Parasitol 122:111-5. 2002
  31. pmc The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation
    Iris Bruchhaus
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Eukaryot Cell 2:501-9. 2003
    ..histolytica or E. dispar trophozoites during in vitro cultivation. Therefore, it is likely that at least some of these enzymes are required for infection of the human host and/or for completion of the parasite life cycle...
  32. ncbi Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum recombination protein PfRad51
    Mrinal Kanti Bhattacharyya
    Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Int J Parasitol 33:1385-92. 2003
    ..PfRad51 is the first apicomplexan gene identified that codes for a recombination protein, and it offers an excellent model for studying DNA damage inducible gene expression in such parasites...
  33. ncbi Direct visualisation of individual gene organisation in Trypanosoma brucei by high-resolution in situ hybridisation
    K Ersfeld
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Chromosoma 107:237-40. 1998
    ..We demonstrated the repetitive nature of the tubulin gene cluster, which consists of up to 19 alpha- and beta-tubulin genes arranged in tandem repeats...
  34. ncbi Rapid evolution of an erythrocyte invasion gene family: the Plasmodium reichenowi Reticulocyte Binding Like (RBL) genes
    Julian C Rayner
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA 30341, USA
    Mol Biochem Parasitol 133:287-96. 2004
    ..The RBL super-family, therefore, appears to be surprisingly dynamic and divergent, implying that it is involved in species-specific aspects of erythrocyte recognition and invasion...
  35. pmc Extragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal microtubules in Chlamydomonas reinhardtii
    A M Preble
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
    Genetics 157:163-81. 2001
    ..It is likely that BLD2 is an essential gene that is needed for basal body assembly and function...
  36. ncbi A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii
    S Taylor
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63130, USA
    Science 314:1776-80. 2006
    ..These attributes of ROP18 required kinase activity, which revealed that secretion of effectors is a major component of parasite virulence...
  37. ncbi Structure and content of the Entamoeba histolytica genome
    C G Clark
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Adv Parasitol 65:51-190. 2007
    ..In this chapter we summarise the features of the genome as they are currently understood and provide previously unpublished analyses of many of the genes...
  38. doi Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
    Trends Parasitol 25:44-51. 2009
    ..vivax and from data gathered from experimental infections in reticulocyte-prone non-lethal malaria parasites and natural P. vivax infections...
  39. pmc Plasmodium falciparum variant surface antigen expression patterns during malaria
    Peter C Bull
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 1:e26. 2005
    ....
  40. ncbi Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locus
    Carlos E Suarez
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Mol Biochem Parasitol 127:101-12. 2003
    ..Immunoblot analysis of merozoites revealed the expected RAP-1a expression but failed to detect expressed RAP-1b and RAP-1c, indicating that expression of the rap-1 genes is regulated both at the transcriptional and translational levels...
  41. pmc Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
    Onguma Natalang
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, 28 rue du Docteur Roux, F 75724, Paris, Cedex 15, France
    BMC Genomics 9:388. 2008
    ..However, few studies to date have used this powerful approach to explore transcriptome alterations of P. falciparum parasites exposed to antimalarial drugs...
  42. ncbi Presence of multiple mRNA cycling sequence element-binding proteins in Crithidia fasciculata
    Bidyottam Mittra
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:26564-71. 2003
    ..Three polypeptides associated with purified CSBP II show specific binding to the cycling sequence. These proteins may represent a family of sequence-specific RNA-binding proteins involved in post-transcriptional regulation...
  43. pmc A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host
    M Wiese
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, D 72076 Tubingen, Germany
    EMBO J 17:2619-28. 1998
    ..Therefore, LMPK is a kinase that is essential for the survival of L.mexicana in the infected host by affecting the cell division of the amastigotes...
  44. pmc Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
    De Hua Lai
    Biology Centre, Institute of Parasitology, Czech Academy of Sciences, 37005 Ceske Budejovice, Czech Republic
    Proc Natl Acad Sci U S A 105:1999-2004. 2008
    ..They should be considered two subspecies, respectively T. brucei equiperdum and T. brucei evansi, which spontaneously arose recently. Dk/Ak trypanosomes may potentially emerge repeatedly from T. brucei...
  45. ncbi Recent origin of Plasmodium falciparum from a single progenitor
    S K Volkman
    The Harvard-Oxford Malaria Genome Diversity Project, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 293:482-4. 2001
    ..These data establish the recent origin of P. falciparum and further provide an explanation for the abundant diversity observed in antigen and other selected genes...
  46. ncbi An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum
    T Triglia
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Mol Biochem Parasitol 116:55-63. 2001
    ..Additionally, it was possible to disrupt the Psi EBA165 gene without affecting the parasite's ability to invade and grow in erythrocytes. These results suggest that the Psi EBA165 gene is a transcribed pseudogene...
  47. ncbi Dinoflagellate expressed sequence tag data indicate massive transfer of chloroplast genes to the nuclear genome
    Tsvetan R Bachvaroff
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Protist 155:65-78. 2004
    ..A preliminary report of these data was presented at the Botany 2002 meeting in Madison, WI...
  48. ncbi Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    ..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
  49. ncbi Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine
    M T Duraisingh
    Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK
    Parasitology 114:205-11. 1997
    ..The samples were genotyped at 3 unlinked polymorphic loci. These analyses suggested that most parasites observed at day 7 were probably recrudescences whereas most of those at day 28 were reinfections...
  50. pmc Multifarious transcriptional regulation of adhesion protein gene ap65-1 by a novel Myb1 protein in the protozoan parasite Trichomonas vaginalis
    Shiou Jeng Ong
    Division of Infectious Diseases, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Eukaryot Cell 5:391-9. 2006
    ..Together, these observations suggest that Myb1 critically regulates multifarious ap65-1 transcription, possibly via differential selection of multiple promoter sites upon environmental changes...
  51. doi Antigenic variation in Plasmodium falciparum
    Artur Scherf
    Biology of Host Parasite Interactions Unit, CNRS URA2581, Institut Pasteur 75724 Paris, France
    Annu Rev Microbiol 62:445-70. 2008
    ..In addition, controversies surrounding var genetic elements in antigenic variation are discussed...
  52. pmc Short hairpin RNA-mediated knockdown of protein expression in Entamoeba histolytica
    Alicia S Linford
    Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA
    BMC Microbiol 9:38. 2009
    ..We chose to test the use of RNA interference to knock down gene expression in Entamoeba histolytica...
  53. ncbi Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
    Arnab Pain
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 309:131-3. 2005
    ....
  54. ncbi Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite
    Emilio F Merino
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de São, Paulo, Av Lineu Prestes 1374, Sao Paulo, SP 05508 900, Brazil
    Mol Biochem Parasitol 149:10-6. 2006
    ..These results suggest that VIR proteins can have different subcellular localizations and functions. This is the first study on a population level of the P. vivax vir subtelomeric multigene superfamily...
  55. ncbi Complete genome sequence of the apicomplexan, Cryptosporidium parvum
    Mitchell S Abrahamsen
    Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Science 304:441-5. 2004
    ..Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development...
  56. pmc Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
    Mallika Imwong
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
    Antimicrob Agents Chemother 52:2657-9. 2008
    ..02). Five coding mutations in pvmdr1, independent of gene amplification, were also found...
  57. pmc Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus
    Chaturong Putaporntip
    Laboratory of Biology and Department of Mathematics, Osaka Institute of Technology, Osaka 535 8585, Japan
    Proc Natl Acad Sci U S A 99:16348-53. 2002
    ..Meanwhile, highly reduced nucleotide diversity was noted in a region encoding the 19-kDa C-terminal epidermal growth factor-like domain of merozoite surface protein-1, a vaccine candidate...
  58. ncbi A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei
    M Navarro
    Present address Instituto de Parasitología y Biomedicina López Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    Nature 414:759-63. 2001
    ..We propose that the recruitment of a single expression site and the concomitant exclusion of inactive loci from a discrete transcriptional body define the mechanism responsible for VSG mono-allelic expression...
  59. pmc Genetic and biochemical analysis of development in Toxoplasma gondii
    J C Boothroyd
    Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305 5402, USA
    Philos Trans R Soc Lond B Biol Sci 352:1347-54. 1997
    ..Chief among the techniques used for these studies are genetics and molecular genetics. Recent progress in these areas is described...
  60. ncbi The ves multigene family of B. bovis encodes components of rapid antigenic variation at the infected erythrocyte surface
    D R Allred
    Department of Pathobiology, University of Florida, Gainesville 32611, USA
    Mol Cell 5:153-62. 2000
    ..Variation appears to involve creation and modification or loss of a novel, transcribed copy of the gene...
  61. ncbi A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts
    Paula L Hawthorne
    University of Queensland, Herston, 4006 QLD, Australia
    Mol Biochem Parasitol 136:181-9. 2004
    ..REX persists in Maurer's clefts throughout the infection of the erythrocyte, where it may play a role in the biogenesis and/or function of this organelle...
  62. pmc Polymorphic secreted kinases are key virulence factors in toxoplasmosis
    J P J Saeij
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 314:1780-3. 2006
    ..Both are hypervariable rhoptry proteins that are secreted into the host cell upon invasion. These results suggest that secreted kinases unique to the Apicomplexa are crucial in the host-pathogen interaction...
  63. pmc Diverse expression patterns of subgroups of the rif multigene family during Plasmodium falciparum gametocytogenesis
    Michaela Petter
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS ONE 3:e3779. 2008
    ..falciparum genome, such as the PfEMP1, STEVOR and RIFIN proteins. While expression of the former two families in sexual stages has been investigated earlier, we report here RIFIN expression during gametocytogenesis...
  64. ncbi A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria
    P R Preiser
    Division of Parasitology, National Institute for Medical Research, London, UK
    Nature 398:618-22. 1999
    ..This phenomenon is genetically and functionally distinct from classical antigenic variation, which is mediated by the var multigene family of P. falciparum...
  65. ncbi YakA, a protein kinase required for the transition from growth to development in Dictyostelium
    G M Souza
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 125:2291-302. 1998
    ..YakA appears to regulate the transition from growth to development in Dictyostelium...
  66. pmc ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data
    Olivier Arnaiz
    Centre de Genetique Moleculaire, CNRS, 91198 Gif sur Yvette, France
    Nucleic Acids Res 35:D439-44. 2007
    ..Future ParameciumDB development plans include coordination of human curation of the near 40 000 gene models by members of the research community...
  67. doi Sampling gene diversity across the supergroup Amoebozoa: large EST data sets from Acanthamoeba castellanii, Hartmannella vermiformis, Physarum polycephalum, Hyperamoeba dachnaya and Hyperamoeba sp
    Russell F Watkins
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Protist 159:269-81. 2008
    ....
  68. pmc Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    RNA 15:116-27. 2009
    ..These sterile transcripts therefore might act in a manner analogous to noncoding RNAs associated with silent, condensed chromatin found in other eukaryotic systems...
  69. pmc Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
    T Triglia
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Proc Natl Acad Sci U S A 91:7149-53. 1994
    ..We have determined the sequence of the DHPS portion of the gene from sulfadoxine-sensitive and -resistant P. falciparum clones and identified sequence differences that may have a role in sulfone/sulfonamide resistance...
  70. ncbi The Trypanosoma cruzi proteome
    J A Atwood
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    Science 309:473-6. 2005
    ..The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes...
  71. pmc Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues
    Karin Kirchgatter
    Departmento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Mol Med 8:16-23. 2002
    ..We analyzed parasites of Brazilian patients with severe malaria to determine whether there were particular DBL1 alpha var sequences predominantly expressed in such patients...
  72. doi Control of gene expression in Plasmodium falciparum - ten years on
    Paul Horrocks
    Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom
    Mol Biochem Parasitol 164:9-25. 2009
    ..and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years...
  73. doi Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
    Christian W Wang
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Int J Parasitol 39:655-64. 2009
    ..This conclusion is experimentally supported by group-specific rif transcription in parasites with different VSA and PfEMP1 expression phenotypes...
  74. pmc A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria
    Stephane Picot
    Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
    Malar J 8:89. 2009
    ..The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number...
  75. pmc Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteins
    R Mahmood
    Molecular Biology Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095-1570, USA
    Mol Cell Biol 21:4453-9. 2001
    ..CSBPA and CSBPB mRNA and protein levels show little variation throughout the cell cycle, suggesting that additional factors are involved in the cyclic binding to the cycling sequence elements...
  76. pmc High recombination rate in natural populations of Plasmodium falciparum
    D J Conway
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 96:4506-11. 1999
    ..falciparum populations. Moreover, the data have major implications for the design and interpretation of population genetic studies of selection on P. falciparum genes...
  77. ncbi KIN241: a gene involved in cell morphogenesis in Paramecium tetraurelia reveals a novel protein family of cyclophilin-RNA interacting proteins (CRIPs) conserved from fission yeast to man
    A Krzywicka
    , Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France
    Mol Microbiol 42:257-67. 2001
    ..No Kin241-1 protein is present in mutant cells, suggesting that the C-terminal serine-rich region is responsible for protein stability...
  78. ncbi Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena
    Kazufumi Mochizuki
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Cell 110:689-99. 2002
    ..We propose that these small RNAs function to specify sequences to be eliminated by a mechanism similar to RNA-mediated gene silencing...
  79. pmc A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variation
    R McCulloch
    The Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, Glasgow G11 6NU, U K
    Genes Dev 13:2875-88. 1999
    ..Switching events were still detectable, however, so it appears that trypanosome factors other than RAD51 can also provide for antigenic variation...
  80. ncbi A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell
    Tomoko Ishino
    Department of Medical Zoology, Mie University School of Medicine, Edobashi, Tsu, Mie 514 0001, Japan
    Mol Microbiol 59:1175-84. 2006
    ..Because humans do not possess CDPK family proteins, CDPK3 is a good target for blocking malarial transmission to the mosquito vector...
  81. pmc Reverse genetics screen identifies six proteins important for malaria development in the mosquito
    Andrea Ecker
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 70:209-20. 2008
    ....
  82. ncbi Differential expression of Leishmania major beta-tubulin genes during the acquisition of promastigote infectivity
    R M Coulson
    Department of Pathology, University of Cambridge, UK
    Mol Biochem Parasitol 82:227-36. 1996
    ..These data demonstrate that the regulation of mRNA half-life contributes to controlling gene expression as promastigotes differentiate into an infectious form...
  83. pmc Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites
    Christoph S Janssen
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Nucleic Acids Res 32:5712-20. 2004
    ....
  84. pmc Microarray analyses of gene expression during the Tetrahymena thermophila life cycle
    Wei Miao
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS ONE 4:e4429. 2009
    ..The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan whose genome has been sequenced, enabling genome-wide analysis of gene expression...
  85. pmc Genetic structure of the mating-type locus of Chlamydomonas reinhardtii
    Patrick J Ferris
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 160:181-200. 2002
    ..This report extends our original conclusion that the MT locus has incurred high levels of mutational change...
  86. ncbi Early origin and recent expansion of Plasmodium falciparum
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Science 300:318-21. 2003
    ..However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings...
  87. pmc Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure
    Robert S Coyne
    J Craig Venter Institute formerly The Institute for Genomic Research, 9704 Medical Center Dr, Rockville, MD, USA
    BMC Genomics 9:562. 2008
    ....
  88. pmc Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated
    H M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 69:3635-45. 2001
    ..falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene...
  89. pmc Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates
    Margaret J Mackinnon
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS Pathog 5:e1000644. 2009
    ..Transcriptional co-regulation of physical clusters of adaptive genes may provide a way for the parasite to readily adapt to its highly heterogeneous and strongly selective environment...
  90. ncbi A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
    Till S Voss
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Nature 439:1004-8. 2006
    ..falciparum. Furthermore, the PfEMP1 knockdown parasites obtained in this study will be important tools to increase our understanding of P. falciparum-mediated virulence and immune evasion...
  91. ncbi ABC transporters and drug resistance in parasitic protozoa
    Antonios Klokouzas
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Int J Antimicrob Agents 22:301-17. 2003
    ..Transporters with an established role in drug resistance have been emphasised, but newly discovered transporters with a significant amino acid sequence identity to established ABC drug transporters have also been included...
  92. pmc Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi
    C A Machado
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:7396-401. 2001
    ..We estimate that the major extant lineages of T. cruzi have diverged during the Miocene or early Pliocene (3-16 million years ago)...
  93. pmc A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genes
    Taco W A Kooij
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Pathog 1:e44. 2005
    ..A majority of these genes are expressed in blood stages, suggesting that the vertebrate host exerts a greater selective pressure than the mosquito vector, resulting in the acquisition of diversity...
  94. ncbi Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes
    Julian C Rayner
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 72:666-74. 2005
    ..Polymorphisms were frequently clustered, suggesting that different RBL domains may be evolving under different selection and functional pressures...
  95. pmc Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family
    Nicolas Joannin
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, SE 17177 Stockholm, Sweden and Swedish Institute for Infectious Diseases Control, SE 17182 Stockholm, Sweden
    BMC Genomics 9:19. 2008
    ....
  96. pmc Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia
    Nimol Khim
    Faculte de Pharmacie, UFR Sciences Pharmaceutiques, UMR INRA Université d Immunologie Parasitaire et de Vaccinologie, 31, avenue Monge Parc Grandmont, 37200 Tours, France
    Antimicrob Agents Chemother 49:3147-52. 2005
    ..Our findings show an alarming rate of multilocus resistance genotypes in Cambodia, requiring diligent surveillance and imposing limitations on possible future drug combinations...
  97. ncbi Targeting malaria virulence and remodeling proteins to the host erythrocyte
    Matthias Marti
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 306:1930-3. 2004
    ..The conservation of this signal across Plasmodium species has implications for the development of new antimalarials...
  98. pmc Regulation of sexual development of Plasmodium by translational repression
    Gunnar R Mair
    Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands
    Science 313:667-9. 2006
    ..Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway...
  99. pmc Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase
    Maureen Wirschell
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Biol Cell 15:2729-41. 2004
    ..We propose that Oda5p is part of a novel axonemal complex that is required for outer arm assembly and anchors adenylate kinase in proximity to the arm...
  100. pmc Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes
    Erik Vassella
    Institute of Cell Biology, University of Bern, CH 3012 Bern, Switzerland
    Mol Biol Cell 15:3986-93. 2004
    ..Our results reveal a new mechanism by which expression of a surface glycoprotein is controlled by the activity of mitochondrial enzymes...
  101. ncbi High coding density on the largest Paramecium tetraurelia somatic chromosome
    Marek Zagulski
    Institute of Biochemistry and Biophysics, DNA Sequencing Laboratory, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Curr Biol 14:1397-404. 2004
    ..Extrapolation to the whole genome suggests that Paramecium has at least 30,000 genes...

Research Grants129 found, 100 shown here

  1. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2010
    ..This study aims to characterize the functions of a group of enzymes that regulate parasite gene expression, which may lead to the design of novel antimalarial drugs. ..
  2. HYPOTRICH GENOME IN DEVELOPMENT AND EVOLUTION
    David Prescott; Fiscal Year: 2001
    ..The experiments deal with the general problem of how an organism can manipulate its own DNA. ..
  3. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 1999
    ..This information will lead to improved protocols for recovering mutants, which is essential for functional genetic screens. ..
  4. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  5. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2005
    ..Promising preliminary data with DNA microarrays have been gathered, and a series of investigations of Leishmania gene expression under a variety of relevant developmental stages and environmental treatments will be carried out. ..
  6. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2006
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  8. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2003
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  9. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  10. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  11. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2010
    ..The expression, cellular localization, and phenotype following targeted gene disruption will be studied for select PHIST domain proteins toward an understanding of their function within the erythrocyte cytoplasm. ..
  12. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
    ..abstract_text> ..
  13. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  14. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  15. MOLECULAR GENETICS OF LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..abstract_text> ..
  16. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  17. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..These studies have yielded new opportunities for chemotherapeutic attack and new directions for future study of pteridine metabolism and biology. ..
  18. DRUG RESISTANCE AND GENE AMPLIFICATION IN LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ..Powerful genetic and bioinformatic screens will be used to identify new biopterin and folate utilizing enzymes and drug targets in aims 2 and 3. ..
  19. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ....
  20. A new family of secreted adhesive proteins in Plasmodium
    THOMAS TEMPLETON; Fiscal Year: 2007
    ....
  21. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2007
    ..This study aims to characterize the functions of a group of enzymes that regulate parasite gene expression, which may lead to the design of novel antimalarial drugs. ..
  22. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  23. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. ..
  24. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Salvatore J Turco; Fiscal Year: 2010
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  25. REPEATED GENES: ORGANIZATION, EVOLUTION AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 1980
    ..The sequence of Tetrahymena histones and of their sites of secondary modification will be examined to determine the relationships between functional and evolutionary divergence. ..
  26. Kinetoplastid SL RNA biogenesis
    David Campbell; Fiscal Year: 2007
    ..Specific inhibition of the trans-splicing pathway is lethal to the cell and thus a prime target for anti-parasite intervention. ..
  27. RNAi in DNA Sequence Elimination in Tetrahymena
    MARTIN GOROVSKY; Fiscal Year: 2007
    ..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
  28. Comparative Evolutionary Genomics and Infectious Disease
    Jane Carlton; Fiscal Year: 2010
    ....
  29. RNAi in DNA Sequence Elimination in Tetrahymena
    Martin A Gorovsky; Fiscal Year: 2010
    ..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
  30. EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENE
    David Campbell; Fiscal Year: 2003
    ..These unique features represent potential targets for selective therapeutic intervention. ..
  31. REPEATED GENES--ORGANIZATION, EVOLUTION AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 2000
    ..no abstract available ..
  32. REPEATED GENES-- ORGANIZATION, EVOLUTION, AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 2004
    ....