protozoan genes

Summary

Summary: The functional hereditary units of PROTOZOA.

Top Publications

  1. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
  2. ncbi Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum
    Tony Triglia
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Mol Microbiol 55:162-74. 2005
  3. ncbi Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
    Jean-Marc Aury
    Genoscope and CNRS UMR 8030, , 91057 Evry, France
    Nature 444:171-8. 2006
  4. ncbi A phylogenetic comparison of gene trees constructed from plastid, mitochondrial and genomic DNA of Plasmodium species
    D Rathore
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892-0425, USA
    Mol Biochem Parasitol 114:89-94. 2001
  5. ncbi Regulation of apicomplexan actin-based motility
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Rev Microbiol 4:621-8. 2006
  6. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
  7. ncbi Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
    Christian W Wang
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Int J Parasitol 39:655-64. 2009
  8. ncbi Control of gene expression in Plasmodium falciparum - ten years on
    Paul Horrocks
    Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom
    Mol Biochem Parasitol 164:9-25. 2009
  9. ncbi Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
  10. ncbi The SRS superfamily of Toxoplasma surface proteins
    Calvin Jung
    Infectious Diseases, Department of Medicine, University of British Columbia, D459 HP East, 2733 Heather Street, Vancouver, BC, Canada V5Z 3J5
    Int J Parasitol 34:285-96. 2004

Research Grants

  1. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2010
  2. HYPOTRICH GENOME IN DEVELOPMENT AND EVOLUTION
    David Prescott; Fiscal Year: 2001
  3. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 1999
  4. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
  5. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2005
  6. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2006
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
  8. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2003
  9. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
  10. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007

Detail Information

Publications188 found, 100 shown here

  1. ncbi The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    Najib M El-Sayed
    Department of Parasite Genomics, Institute for Genomic Research, Rockville, MD 20850, USA
    Science 309:409-15. 2005
    ....
  2. ncbi Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum
    Tony Triglia
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Mol Microbiol 55:162-74. 2005
    ..falciparum parasites to utilize alternative receptors on the erythrocyte surface for evasion of receptor polymorphisms and the host immune system...
  3. ncbi Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia
    Jean-Marc Aury
    Genoscope and CNRS UMR 8030, , 91057 Evry, France
    Nature 444:171-8. 2006
    ..The conclusion of this analysis is that many genes are maintained after whole-genome duplication not because of functional innovation but because of gene dosage constraints...
  4. ncbi A phylogenetic comparison of gene trees constructed from plastid, mitochondrial and genomic DNA of Plasmodium species
    D Rathore
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892-0425, USA
    Mol Biochem Parasitol 114:89-94. 2001
    ..falciparum...
  5. ncbi Regulation of apicomplexan actin-based motility
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Rev Microbiol 4:621-8. 2006
    ....
  6. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  7. ncbi Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite lines
    Christian W Wang
    Centre for Medical Parasitology at Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark
    Int J Parasitol 39:655-64. 2009
    ..This conclusion is experimentally supported by group-specific rif transcription in parasites with different VSA and PfEMP1 expression phenotypes...
  8. ncbi Control of gene expression in Plasmodium falciparum - ten years on
    Paul Horrocks
    Institute for Science and Technology in Medicine, Keele University, Staffordshire ST5 5BG, United Kingdom
    Mol Biochem Parasitol 164:9-25. 2009
    ..and apicomplexan parasites. Specifically, however, we will address the current polarised debate regarding the level at which control is mediated, and attempt to identify some of the challenges this field faces in the next 10 years...
  9. ncbi Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia
    Helen M Kyriacou
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 150:211-8. 2006
    ..These results suggest that var genes with DBLalpha1-like domains (Group A or B/A) may be implicated in the pathogenesis of cerebral malaria, while var genes with DBLalpha0-like domains promote less virulent malaria infections...
  10. ncbi The SRS superfamily of Toxoplasma surface proteins
    Calvin Jung
    Infectious Diseases, Department of Medicine, University of British Columbia, D459 HP East, 2733 Heather Street, Vancouver, BC, Canada V5Z 3J5
    Int J Parasitol 34:285-96. 2004
    ..Orthologous genes are restricted to tissue-dwelling coccidia (Neospora, Sarcocystis) with no related sequences present in other more distant apicomplexa such as Eimeria, Cryptosporidia, and Plasmodium spp...
  11. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria...
  12. ncbi Presence of multiple mRNA cycling sequence element-binding proteins in Crithidia fasciculata
    Bidyottam Mittra
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 278:26564-71. 2003
    ..Three polypeptides associated with purified CSBP II show specific binding to the cycling sequence. These proteins may represent a family of sequence-specific RNA-binding proteins involved in post-transcriptional regulation...
  13. ncbi Recent origin of Plasmodium falciparum from a single progenitor
    S K Volkman
    The Harvard-Oxford Malaria Genome Diversity Project, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 293:482-4. 2001
    ..These data establish the recent origin of P. falciparum and further provide an explanation for the abundant diversity observed in antigen and other selected genes...
  14. ncbi An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum
    T Triglia
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Mol Biochem Parasitol 116:55-63. 2001
    ..Additionally, it was possible to disrupt the Psi EBA165 gene without affecting the parasite's ability to invade and grow in erythrocytes. These results suggest that the Psi EBA165 gene is a transcribed pseudogene...
  15. ncbi Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
    De Hua Lai
    Biology Centre, Institute of Parasitology, Czech Academy of Sciences, 37005 Ceske Budejovice, Czech Republic
    Proc Natl Acad Sci U S A 105:1999-2004. 2008
    ..They should be considered two subspecies, respectively T. brucei equiperdum and T. brucei evansi, which spontaneously arose recently. Dk/Ak trypanosomes may potentially emerge repeatedly from T. brucei...
  16. ncbi A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host
    M Wiese
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, D 72076 Tubingen, Germany
    EMBO J 17:2619-28. 1998
    ..Therefore, LMPK is a kinase that is essential for the survival of L.mexicana in the infected host by affecting the cell division of the amastigotes...
  17. ncbi Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
    Jane M Carlton
    Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA
    Science 315:207-12. 2007
    ..The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria...
  18. ncbi Dinoflagellate expressed sequence tag data indicate massive transfer of chloroplast genes to the nuclear genome
    Tsvetan R Bachvaroff
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Protist 155:65-78. 2004
    ..A preliminary report of these data was presented at the Botany 2002 meeting in Madison, WI...
  19. ncbi Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    ..The genome sequence provides a greater understanding of B. bovis metabolism and potential avenues for drug therapies and vaccine development...
  20. ncbi Sampling gene diversity across the supergroup Amoebozoa: large EST data sets from Acanthamoeba castellanii, Hartmannella vermiformis, Physarum polycephalum, Hyperamoeba dachnaya and Hyperamoeba sp
    Russell F Watkins
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Protist 159:269-81. 2008
    ....
  21. ncbi ParameciumDB: a community resource that integrates the Paramecium tetraurelia genome sequence with genetic data
    Olivier Arnaiz
    Centre de Genetique Moleculaire, CNRS, 91198 Gif sur Yvette, France
    Nucleic Acids Res 35:D439-44. 2007
    ..Future ParameciumDB development plans include coordination of human curation of the near 40 000 gene models by members of the research community...
  22. ncbi Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate
    Onguma Natalang
    Institut Pasteur, Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, 28 rue du Docteur Roux, F 75724, Paris, Cedex 15, France
    BMC Genomics 9:388. 2008
    ..However, few studies to date have used this powerful approach to explore transcriptome alterations of P. falciparum parasites exposed to antimalarial drugs...
  23. ncbi YakA, a protein kinase required for the transition from growth to development in Dictyostelium
    G M Souza
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 125:2291-302. 1998
    ..YakA appears to regulate the transition from growth to development in Dictyostelium...
  24. ncbi A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria
    P R Preiser
    Division of Parasitology, National Institute for Medical Research, London, UK
    Nature 398:618-22. 1999
    ..This phenomenon is genetically and functionally distinct from classical antigenic variation, which is mediated by the var multigene family of P. falciparum...
  25. ncbi Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
    Trends Parasitol 25:44-51. 2009
    ..vivax and from data gathered from experimental infections in reticulocyte-prone non-lethal malaria parasites and natural P. vivax infections...
  26. ncbi Diverse expression patterns of subgroups of the rif multigene family during Plasmodium falciparum gametocytogenesis
    Michaela Petter
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS ONE 3:e3779. 2008
    ..falciparum genome, such as the PfEMP1, STEVOR and RIFIN proteins. While expression of the former two families in sexual stages has been investigated earlier, we report here RIFIN expression during gametocytogenesis...
  27. ncbi Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    RNA 15:116-27. 2009
    ..These sterile transcripts therefore might act in a manner analogous to noncoding RNAs associated with silent, condensed chromatin found in other eukaryotic systems...
  28. ncbi Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum
    T Triglia
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Proc Natl Acad Sci U S A 91:7149-53. 1994
    ..We have determined the sequence of the DHPS portion of the gene from sulfadoxine-sensitive and -resistant P. falciparum clones and identified sequence differences that may have a role in sulfone/sulfonamide resistance...
  29. ncbi Reverse genetics screen identifies six proteins important for malaria development in the mosquito
    Andrea Ecker
    Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 70:209-20. 2008
    ....
  30. ncbi The genome of the simian and human malaria parasite Plasmodium knowlesi
    A Pain
    Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Nature 455:799-803. 2008
    ..One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry...
  31. ncbi Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteins
    R Mahmood
    Molecular Biology Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095-1570, USA
    Mol Cell Biol 21:4453-9. 2001
    ..CSBPA and CSBPB mRNA and protein levels show little variation throughout the cell cycle, suggesting that additional factors are involved in the cyclic binding to the cycling sequence elements...
  32. ncbi Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation
    J E Brownell
    Department of Biology, University of Rochester, New York, 14627, USA
    Cell 84:843-51. 1996
    ..These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histone acetylation is a targeted phenomenon...
  33. ncbi Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum recombination protein PfRad51
    Mrinal Kanti Bhattacharyya
    Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    Int J Parasitol 33:1385-92. 2003
    ..PfRad51 is the first apicomplexan gene identified that codes for a recombination protein, and it offers an excellent model for studying DNA damage inducible gene expression in such parasites...
  34. ncbi Refined annotation and assembly of the Tetrahymena thermophila genome sequence through EST analysis, comparative genomic hybridization, and targeted gap closure
    Robert S Coyne
    J Craig Venter Institute formerly The Institute for Genomic Research, 9704 Medical Center Dr, Rockville, MD, USA
    BMC Genomics 9:562. 2008
    ....
  35. ncbi Microarray analyses of gene expression during the Tetrahymena thermophila life cycle
    Wei Miao
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS ONE 4:e4429. 2009
    ..The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan whose genome has been sequenced, enabling genome-wide analysis of gene expression...
  36. ncbi Multifarious transcriptional regulation of adhesion protein gene ap65-1 by a novel Myb1 protein in the protozoan parasite Trichomonas vaginalis
    Shiou-Jeng Ong
    Division of Infectious Diseases, Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Eukaryot Cell 5:391-9. 2006
    ..Together, these observations suggest that Myb1 critically regulates multifarious ap65-1 transcription, possibly via differential selection of multiple promoter sites upon environmental changes...
  37. ncbi Protection against Leishmania donovani infection by DNA vaccination: increased DNA vaccination efficiency through inhibiting the cellular p53 response
    A Ghosh
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Montreal, H3A 2B4, Quebec, Canada
    Vaccine 19:3169-78. 2001
    ..These results have important implications for DNA vaccination against leishmaniasis and potentially against other infectious diseases...
  38. ncbi Early origin and recent expansion of Plasmodium falciparum
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Science 300:318-21. 2003
    ..However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings...
  39. ncbi Genetic structure of the mating-type locus of Chlamydomonas reinhardtii
    Patrick J Ferris
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Genetics 160:181-200. 2002
    ..This report extends our original conclusion that the MT locus has incurred high levels of mutational change...
  40. ncbi Rapid evolution of an erythrocyte invasion gene family: the Plasmodium reichenowi Reticulocyte Binding Like (RBL) genes
    Julian C Rayner
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA 30341, USA
    Mol Biochem Parasitol 133:287-96. 2004
    ..The RBL super-family, therefore, appears to be surprisingly dynamic and divergent, implying that it is involved in species-specific aspects of erythrocyte recognition and invasion...
  41. ncbi Comparative transcriptional and genomic analysis of Plasmodium falciparum field isolates
    Margaret J Mackinnon
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS Pathog 5:e1000644. 2009
    ..Transcriptional co-regulation of physical clusters of adaptive genes may provide a way for the parasite to readily adapt to its highly heterogeneous and strongly selective environment...
  42. ncbi A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genes
    Taco W A Kooij
    Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Pathog 1:e44. 2005
    ..A majority of these genes are expressed in blood stages, suggesting that the vertebrate host exerts a greater selective pressure than the mosquito vector, resulting in the acquisition of diversity...
  43. ncbi A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
    Till S Voss
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    Nature 439:1004-8. 2006
    ..falciparum. Furthermore, the PfEMP1 knockdown parasites obtained in this study will be important tools to increase our understanding of P. falciparum-mediated virulence and immune evasion...
  44. ncbi Comparative genomics of trypanosomatid parasitic protozoa
    Najib M El-Sayed
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:404-9. 2005
    ..Contrary to recent reports, our analyses reveal no evidence that these species are descended from an ancestor that contained a photosynthetic endosymbiont...
  45. ncbi PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia
    Céline Baudry
    CNRS FRE 3144, Centre de Genetique Moleculaire, Gif sur Yvette F 91198 Cedex, France
    Genes Dev 23:2478-83. 2009
    ..This is the first in vivo evidence suggesting an essential endonucleolytic function of a domesticated piggyBac transposase...
  46. ncbi ABC transporters and drug resistance in parasitic protozoa
    Antonios Klokouzas
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Int J Antimicrob Agents 22:301-17. 2003
    ..Transporters with an established role in drug resistance have been emphasised, but newly discovered transporters with a significant amino acid sequence identity to established ABC drug transporters have also been included...
  47. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  48. ncbi Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated
    H M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 69:3635-45. 2001
    ..falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene...
  49. ncbi Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi
    C A Machado
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:7396-401. 2001
    ..We estimate that the major extant lineages of T. cruzi have diverged during the Miocene or early Pliocene (3-16 million years ago)...
  50. ncbi Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes
    Julian C Rayner
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 72:666-74. 2005
    ..Polymorphisms were frequently clustered, suggesting that different RBL domains may be evolving under different selection and functional pressures...
  51. ncbi Genetic structure of Plasmodium falciparum populations in the Brazilian Amazon region
    Ricardo L D Machado
    Malaria Laboratory, Evandro Chagas Institute and National Health Foundation, , Brazil
    J Infect Dis 190:1547-55. 2004
    ..falciparum in Brazil are quite independent, with distinct population structures and minimal gene flow, a finding that has implications for strategies to control infection and to contain the spread of drug resistance at a regional level...
  52. ncbi Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase
    Maureen Wirschell
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Biol Cell 15:2729-41. 2004
    ..We propose that Oda5p is part of a novel axonemal complex that is required for outer arm assembly and anchors adenylate kinase in proximity to the arm...
  53. ncbi Full-malaria 2004: an enlarged database for comparative studies of full-length cDNAs of malaria parasites, Plasmodium species
    Junichi Watanabe
    Department of Parasitology, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Nucleic Acids Res 32:D334-8. 2004
    ....
  54. ncbi Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes
    Erik Vassella
    Institute of Cell Biology, University of Bern, CH 3012 Bern, Switzerland
    Mol Biol Cell 15:3986-93. 2004
    ..Our results reveal a new mechanism by which expression of a surface glycoprotein is controlled by the activity of mitochondrial enzymes...
  55. ncbi High coding density on the largest Paramecium tetraurelia somatic chromosome
    Marek Zagulski
    Institute of Biochemistry and Biophysics, DNA Sequencing Laboratory, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland
    Curr Biol 14:1397-404. 2004
    ..Extrapolation to the whole genome suggests that Paramecium has at least 30,000 genes...
  56. ncbi Targeting malaria virulence and remodeling proteins to the host erythrocyte
    Matthias Marti
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 306:1930-3. 2004
    ..The conservation of this signal across Plasmodium species has implications for the development of new antimalarials...
  57. ncbi TbRAB1 and TbRAB2 mediate trafficking through the early secretory pathway of Trypanosoma brucei
    Vivek Dhir
    Department of Biological Sciences, Imperial College, London, SW7 2AY, UK
    Mol Biochem Parasitol 137:253-65. 2004
    ..These data indicate conservation of function for these proteins between trypanosomes and crown eukaryotes...
  58. ncbi Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites
    Christoph S Janssen
    Institute of Biomedical and Life Sciences, Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Nucleic Acids Res 32:5712-20. 2004
    ....
  59. ncbi Transgene-mediated post-transcriptional gene silencing is inhibited by 3' non-coding sequences in Paramecium
    A Galvani
    , CNRS, 91198 Gif-sur-Yvette Cedex, France
    Nucleic Acids Res 29:4387-94. 2001
    ....
  60. ncbi Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia
    Nimol Khim
    Faculte de Pharmacie, UFR Sciences Pharmaceutiques, UMR INRA Université d Immunologie Parasitaire et de Vaccinologie, 31, avenue Monge Parc Grandmont, 37200 Tours, France
    Antimicrob Agents Chemother 49:3147-52. 2005
    ..Our findings show an alarming rate of multilocus resistance genotypes in Cambodia, requiring diligent surveillance and imposing limitations on possible future drug combinations...
  61. ncbi Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family
    Nicolas Joannin
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, SE 17177 Stockholm, Sweden and Swedish Institute for Infectious Diseases Control, SE 17182 Stockholm, Sweden
    BMC Genomics 9:19. 2008
    ....
  62. ncbi Regulation of sexual development of Plasmodium by translational repression
    Gunnar R Mair
    Department of Parasitology, Leiden University Medical Centre, 2333 ZA Leiden, Netherlands
    Science 313:667-9. 2006
    ..Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway...
  63. ncbi Molecular and phylogenetic characterization of syntaxin genes from parasitic protozoa
    Joel B Dacks
    Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5
    Mol Biochem Parasitol 136:123-36. 2004
    ..Because of their integral role in membrane trafficking, the syntaxin genes represent a valuable potential molecular marker for the experimental study of the endomembrane system of disease-causing protists...
  64. ncbi Two linked genes of Leishmania infantum encode tryparedoxins localised to cytosol and mitochondrion
    Helena Castro
    Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150-180 Porto, Portugal
    Mol Biochem Parasitol 136:137-47. 2004
    ..infantum...
  65. ncbi Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation
    Carlos Gustavo Regis-da-Silva
    Department of Biochemistry and Immunology, ICB, Universidade Federal de Minas Gerais, , 6627, Caixa Postal 486, Belo Horizonte 30161-970, MG, Brazil
    Mol Biochem Parasitol 149:191-200. 2006
    ..Furthermore, transfected parasites over-expressing TcRad51 have a faster kinetics of recovery of the normal pattern of chromosomal bands after irradiation as well as a higher resistance to zeocin treatment than do wild-type cultures...
  66. ncbi The beta-N-acetylhexosaminidase of Entamoeba histolytica is composed of two homologous chains and has been localized to cytoplasmic granules
    Sabine Riekenberg
    Department of Biochemistry, University of Osnabrueck, 49069 Osnabrueck, Germany
    Mol Biochem Parasitol 138:217-25. 2004
    ..Its localization in cytoplasmic granules strengthens the notion that the hexosaminidase complex may contribute to amoebic pathogenicity...
  67. ncbi Mating-induced shedding of cell walls, removal of walls from vegetative cells, and osmotic stress induce presumed cell wall genes in Chlamydomonas
    Xenia-Katharina Hoffmann
    Institute of Biology III, Albert-Ludwigs-University, Freiburg, Germany
    Plant Physiol 139:999-1014. 2005
    ..Also under such conditions an activation of the genes was observed, suggesting that the signaling pathway(s) is (are) activated by wall removal itself...
  68. ncbi Identification of a gene induced in conjugation-promoted cells of toxic marine dinoflagellates Alexandrium tamarense and Alexandrium catenella using differential display analysis
    Shoko Hosoi-Tanabe
    Department of Ecosystem Studies, School of Environmental Science, The University of Shiga Prefecture, Hikone, Shiga 522 8533, Japan
    FEMS Microbiol Lett 251:161-8. 2005
    ..Characterization of the identified gene might help in understanding the mechanism of encystment...
  69. ncbi Specific DNA-binding by apicomplexan AP2 transcription factors
    Erandi K De Silva
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, 246 Carl Icahn Laboratory, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 105:8393-8. 2008
    ..Because of their origin in the plant lineage, ApiAP2 proteins have no homologues in the human host and may prove to be ideal antimalarial targets...
  70. ncbi The role of metacaspase 1 in Plasmodium berghei development and apoptosis
    Ludovic Le Chat
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Mol Biochem Parasitol 153:41-7. 2007
    ..We failed to detect an apparent loss-of-function phenotype, suggesting that PbMC1 constitutes a functionally redundant gene. We discuss these findings in the context of two other putative Plasmodium metacaspases that we describe here...
  71. ncbi Direct observation of histone H2B-YFP fusion proteins and transport of their mRNA between conjugating Paramecia
    Yasuhiro Takenaka
    Department of Biochemistry, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Gene 395:108-15. 2007
    ..We concluded that at least the mRNA of histone H2B-PcVenus was transferred from the transformed, to the untransformed cell during conjugation...
  72. ncbi Regulation of trypanosome DNA glycosylation by a SWI2/SNF2-like protein
    Courtney DiPaolo
    Global Infectious Diseases Program, Marine Biological Laboratory, Woods Hole, MA 02543, USA
    Mol Cell 17:441-51. 2005
    ..We propose a model in which chromatin remodeling by JBP2 regulates the initial sites of J synthesis within bloodstream form trypanosome DNA, with further propagation and maintenance of J by JBP1...
  73. ncbi Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene family
    Federica Verra
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Mol Biochem Parasitol 149:182-90. 2006
    ..Population expansion simulations were performed under a neutral model, further supporting the departures from neutrality of these genes...
  74. ncbi Identification and characterization of a novel alpha-kinase with a von Willebrand factor A-like motif localized to the contractile vacuole and Golgi complex in Dictyostelium discoideum
    Venkaiah Betapudi
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106 4970, USA
    Mol Biol Cell 16:2248-62. 2005
    ..We propose that VwkA likely acts indirectly to influence myosin II abundance and assembly behavior and possibly has broader roles than previously characterized alpha kinases in this organism, which all seem to be MHCKs...
  75. ncbi Isolation and characterization of Plasmodium falciparum UAP56 homolog: evidence for the coupling of RNA binding and splicing activity by site-directed mutations
    Jay Shankar
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 478:143-53. 2008
    ..In the present study we have reported the detailed characterization of PfU52 from P. falciparum and these results advance the knowledge regarding the function of UAP56 in general...
  76. ncbi Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum. Spherulin 3b and polymalatase
    Nadthanan Pinchai
    , Germany
    FEBS J 273:1046-55. 2006
    ..Quantitative PCR then revealed low levels of mRNA in amoebae, high levels in plasmodia, and also low levels in spherules, in agreement with the expression under transcriptional regulation in these cells...
  77. ncbi Cloning and characterization of a Dictyostelium discoideum cDNA encoding a protein related to the medium chain subunit of clathrin-associated adaptor complexes
    L A Temesvari
    Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130, USA
    Gene 183:47-51. 1996
    ..DdApm1 is the first reported full-length cDNA encoding a subunit of an AP complex in D. discoideum, and thus provides the first evidence for the existence of AP complexes in this organism...
  78. ncbi Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase
    M Wiese
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Tubingen, Germany
    EMBO J 14:1067-74. 1995
    ..The Ser/Thr-rich domains are the targets for phosphoglycan modifications as shown by the expression of secreted fusion proteins composed of these C-terminal regions and the N-terminal domain of a lysosomal acid phosphatase...
  79. ncbi LbrA, a protein predicted to have a role in vesicle trafficking, is necessary for normal morphogenesis in Polysphondylium pallidum
    Y Kawabe
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Gene 239:75-9. 1999
    ..As far as we know, this is the first paper to show that a p24 family member is implicated in morphogenesis...
  80. ncbi Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children
    Francine Ntoumi
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Immunol Lett 84:9-16. 2002
    ..The role of the high multiclonal carriage associated with high family-specific antibodies reactive to MSP2 in HbAS children with asymptomatic P. falciparum parasitism is discussed...
  81. ncbi Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote
    J D Bangs
    Department of Microbiology and Immunology, Stanford School of Medicine, CA 94305 5402
    J Cell Sci 105:1101-13. 1993
    ..1989) Biochemistry 28, 6440-6446), indicates that endoplasmic reticulum retrieval signals in trypanosomes may be as divergent and heterogeneous as any seen in the other eukaryotes yet studied...
  82. ncbi Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum
    Deborah L Baldi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Infect Immun 70:5236-45. 2002
    ..falciparum; however, there is a single gene. Phylogenetic comparison of the RAP2/3 protein family from Plasmodium spp. suggests that the RAP2/3 duplication occurred after divergence of these parasite species...
  83. ncbi Simultaneous expression of different variant-specific surface proteins in single Giardia lamblia trophozoites during encystation
    Pedro G Carranza
    , , , , Argentina
    Infect Immun 70:5265-8. 2002
    ..These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related...
  84. ncbi Variation in the expression of a Plasmodium falciparum protein family implicated in erythrocyte invasion
    Helen M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 70:5779-89. 2002
    ..The apparent redundancy in the PfRH family of proteins at the level of gene number and sequence and the variations in transcription and protein expression may allow the parasite to use alternative invasion pathways...
  85. ncbi Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena
    Kazufumi Mochizuki
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Cell 110:689-99. 2002
    ..We propose that these small RNAs function to specify sequences to be eliminated by a mechanism similar to RNA-mediated gene silencing...
  86. ncbi Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum
    Mauro Delorenzi
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Infect Immun 70:4510-22. 2002
    ..The biosynthetic pathway of the malaria parasite GPI offers potential targets for drug development and may be useful for studying parasite cell biology and the molecular basis for the pathophysiology of parasitic diseases...
  87. ncbi Analysis of sequence diversity at the highly polymorphic Cpgp40/15 locus among Cryptosporidium isolates from human immunodeficiency virus-infected children in South Africa
    Brett A Leav
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 70:3881-90. 2002
    ..Lastly, children infected with isolates having genotype Ic alleles were significantly older than those infected with isolates displaying other genotype I alleles...
  88. ncbi Identification of a disulfide isomerase protein of Leishmania major as a putative virulence factor
    Y Ben Achour
    Laboratoire d'Immunologie (LAF301, Institut Pasteur de Tunis, , Tunisia
    Infect Immun 70:3576-85. 2002
    ..These findings suggest that LmPDI may play an important role in Leishmania natural pathogenicity and may constitute a new target for anti-Leishmania chemotherapy...
  89. ncbi The Babesia bovis merozoite surface antigen 2 locus contains four tandemly arranged and expressed genes encoding immunologically distinct proteins
    Monica Florin-Christensen
    Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040, USA
    Infect Immun 70:3566-75. 2002
    ..The results support the evolution of the msa-2 locus through at least two gene duplications, with selection for multiple related but antigenically distinct merozoite surface proteins...
  90. ncbi Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei
    V B Carruthers
    Laboratory of Molecular Parasitology, Rockefeller University, New York, NY 10021 6399, USA
    Mol Biochem Parasitol 81:65-79. 1996
    ..We have therefore been unable to determine whether esag1 is an essential gene, or what function it fulfils, or whether any competent Esag1 protein is expressed in the mutant trypanosomes...
  91. ncbi Structure and expression of a post-transcriptionally regulated malaria gene encoding a surface protein from the sexual stages of Plasmodium berghei
    M G Paton
    Department of Biology, Imperial College of Science, Technology and Medicine, London, UK
    Mol Biochem Parasitol 59:263-75. 1993
    ..The Pbs21 gene and the P. berghei parasite system provide an excellent vehicle for the study of stage-specific transcriptional and post-transcriptional control in malaria...
  92. ncbi A second functional delta5 fatty acid desaturase in the cellular slime mould Dictyostelium discoideum
    T Saito
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Eur J Biochem 267:1813-8. 2000
    ..The substrate specificities of the two functional Delta5 desaturases of D. discoideum were also examined...
  93. ncbi A novel Dictyostelium gene encoding multiple repeats of adhesion inhibitor-like domains has effects on cell-cell and cell-substrate adhesion
    Timothy R Varney
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Dev Biol 243:226-48. 2002
    ..We propose that the AmpA protein functions as an anti-adhesive to limit cell-cell and cell-substrate adhesion during development and thus facilitates cell migration during morphogenesis...
  94. ncbi The gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei
    Y Wu
    Department of Biological Sciences, Southern Methodist University, Dallas, TX 75235
    Biochem J 304:833-41. 1994
    ..We demonstrate that this variability resulted from amino acid substitutions at the N-terminus, C-terminal extensions, and duplication of internal segments...
  95. ncbi Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium
    G R Schnitzler
    Department of Biology, University of California, San Diego, La Jolla 92093 0634
    Genes Dev 8:502-14. 1994
    ..Our results indicate that GBF acts as an extracellular cAMP-responsive transcriptional activator regulating late gene expression and is an essential component of a developmental switch between aggregation and cellular morphogenesis...
  96. ncbi Cloning and characterization of a novel Plasmodium falciparum sporozoite surface antigen, STARP
    D A Fidock
    Laboratory of Biomedical Parasitology, Pasteur Institute, Paris, France
    Mol Biochem Parasitol 64:219-32. 1994
    ..Identification and elucidation of this novel antigen is a step forward in current efforts aimed at developing an effective preerythrocytic-stage malaria vaccine...
  97. ncbi Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues
    Karin Kirchgatter
    Departmento de Parasitologia, , , Brazil
    Mol Med 8:16-23. 2002
    ..CONCLUSIONS: This is the first report showing an association of severe noncerebral malaria from Brazil with particular DBL1 alpha sequences...
  98. ncbi Molecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum
    J J Möhrle
    Department of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Biochem J 328:677-87. 1997
    ..PfPK4 co-localizes with P. falciparum 83 kDa antigen/apical membrane antigen-1 at the apical complex in segmenters and merozoites, but does not co-localize with rhoptry-associated protein-1...
  99. ncbi Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum
    Sarah K Volkman
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 298:216-8. 2002
    ..Genetic variation is also enriched in subtelomeric regions, which account for 22% of the chromosome but 76% of the polymorphisms...
  100. ncbi Structure, organization and expression of the genes encoding mitochondrial cytochrome c(1) and the Rieske iron-sulfur protein in Chlamydomonas reinhardtii
    A Atteia
    Departamento de Genetica Molecular, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 243, 04510 Mexico D F, Mexico
    Mol Genet Genomics 268:637-44. 2003
    ..These data show that, in the green alga C. reinhardtii, the subunits of the cytochrome bc(1) complex fail to assemble properly in the absence of cytochrome b...
  101. ncbi Incorporation of iron into Tritrichomonas foetus cell compartments reveals ferredoxin as a major iron-binding protein in hydrogenosomes
    Pavel Suchan
    Department of Parasitology, Faculty of Science, Charles University, , 128 44, Prague 2, Czech Republic
    Microbiology 149:1911-21. 2003
    ..Analysis of Tt. foetus hydrogenosomes showed at least nine iron-binding compounds, which were absent in metronidazole-resistant mutants. The major iron-binding compound was identified as [2Fe-2S] ferredoxin of the adrenodoxin type...

Research Grants129 found, 100 shown here

  1. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2010
    ..This study aims to characterize the functions of a group of enzymes that regulate parasite gene expression, which may lead to the design of novel antimalarial drugs. ..
  2. HYPOTRICH GENOME IN DEVELOPMENT AND EVOLUTION
    David Prescott; Fiscal Year: 2001
    ..The experiments deal with the general problem of how an organism can manipulate its own DNA. ..
  3. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 1999
    ..This information will lead to improved protocols for recovering mutants, which is essential for functional genetic screens. ..
  4. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  5. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2005
    ..Promising preliminary data with DNA microarrays have been gathered, and a series of investigations of Leishmania gene expression under a variety of relevant developmental stages and environmental treatments will be carried out. ..
  6. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2006
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  8. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2003
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  9. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  10. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ..As one example, we will study a genetic model (phosphoglycan-deficiency) which separates acute virulence from persistence, and explore its utility in vaccine strategies. ..
  11. The Plasmodium 2TM and PHIST protein families
    Thomas J Templeton; Fiscal Year: 2010
    ..The expression, cellular localization, and phenotype following targeted gene disruption will be studied for select PHIST domain proteins toward an understanding of their function within the erythrocyte cytoplasm. ..
  12. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
    ..abstract_text> ..
  13. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  14. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2009
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  15. MOLECULAR GENETICS OF LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..abstract_text> ..
  16. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  17. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..These studies have yielded new opportunities for chemotherapeutic attack and new directions for future study of pteridine metabolism and biology. ..
  18. DRUG RESISTANCE AND GENE AMPLIFICATION IN LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ..Powerful genetic and bioinformatic screens will be used to identify new biopterin and folate utilizing enzymes and drug targets in aims 2 and 3. ..
  19. MOLECULAR GENETICS OF LEISHMANIA
    Stephen Beverley; Fiscal Year: 2007
    ....
  20. A new family of secreted adhesive proteins in Plasmodium
    THOMAS TEMPLETON; Fiscal Year: 2007
    ....
  21. Malaria HATs in Transcription Regulation
    Liwang Cui; Fiscal Year: 2007
    ..This study aims to characterize the functions of a group of enzymes that regulate parasite gene expression, which may lead to the design of novel antimalarial drugs. ..
  22. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  23. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. ..
  24. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Salvatore J Turco; Fiscal Year: 2010
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  25. REPEATED GENES: ORGANIZATION, EVOLUTION AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 1980
    ..The sequence of Tetrahymena histones and of their sites of secondary modification will be examined to determine the relationships between functional and evolutionary divergence. ..
  26. Kinetoplastid SL RNA biogenesis
    David Campbell; Fiscal Year: 2007
    ..Specific inhibition of the trans-splicing pathway is lethal to the cell and thus a prime target for anti-parasite intervention. ..
  27. RNAi in DNA Sequence Elimination in Tetrahymena
    MARTIN GOROVSKY; Fiscal Year: 2007
    ..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
  28. Comparative Evolutionary Genomics and Infectious Disease
    Jane Carlton; Fiscal Year: 2010
    ....
  29. RNAi in DNA Sequence Elimination in Tetrahymena
    Martin A Gorovsky; Fiscal Year: 2010
    ..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
  30. EXPRESSION OF THE LEISHMANIA TARENTOLAE SL RNA GENE
    David Campbell; Fiscal Year: 2003
    ..These unique features represent potential targets for selective therapeutic intervention. ..
  31. REPEATED GENES--ORGANIZATION, EVOLUTION AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 2000
    ..no abstract available ..
  32. REPEATED GENES-- ORGANIZATION, EVOLUTION, AND FUNCTION
    MARTIN GOROVSKY; Fiscal Year: 2004
    ....