t cell receptor beta genes

Summary

Summary: DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.

Top Publications

  1. pmc Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis
    H Jiang
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:8378-83. 2003
  2. pmc Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size
    J L Matsuda
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:12636-41. 2001
  3. ncbi Genomic organization of the chicken T-cell receptor beta chain D-J-C region
    Akiko Shigeta
    Laboratory of Immunobiology, Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Hiroshima 739 8528, Japan
    J Vet Med Sci 66:1509-15. 2004
  4. ncbi Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques
    David A Price
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 180:269-80. 2008
  5. pmc Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses
    Edwin R Manuel
    Beth Israel Deaconess Medical Center, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    J Virol 80:12032-40. 2006
  6. pmc Clonal focusing of epitope-specific CD8+ T lymphocytes in rhesus monkeys following vaccination and simian-human immunodeficiency virus challenge
    Pritha Sen
    Beth Israel Deaconess Medical Center, Division of Viral Pathogenesis, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 82:805-16. 2008
  7. ncbi Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    Maria Ciofani
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    J Immunol 172:5230-9. 2004
  8. ncbi A survival guide to early T cell development
    Maria Ciofani
    Department of Immunology, University of Toronto, and Sunnybrook and Women s Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Immunol Res 34:117-32. 2006
  9. pmc Maintenance of CD4+ T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, WMB rm 2337A, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Virology 369:324-8. 2007
  10. ncbi Organization, structure and evolution of 41kb of genomic DNA spanning the D-J-C region of the sheep TRB locus
    R Antonacci
    Dipartimento di Genetica e Microbiologia, Universita degli Studi di Bari, Italy
    Mol Immunol 45:493-509. 2008

Research Grants

  1. MOLECULAR PATHOLOGY OF LEUKEMIA/LYMPHOID MARKER
    KAREN CHANCELLOR; Fiscal Year: 1992
  2. MOLECULAR PATHOLOGY OF LEUKEMIA/LYMPHOID MARKER
    KAREN CHANCELLOR; Fiscal Year: 1993
  3. ALLOGENEIC RESPONSE:ROLE OF T CELL RECEPTOR DIVERSITY
    Carolyn Hurley; Fiscal Year: 1990
  4. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2007
  5. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  6. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY BURROWS; Fiscal Year: 2007
  7. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2007
  8. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2007
  9. HLA-DQ-derived RTLs for Treatment of Celiac Disease
    GREGORY BURROWS; Fiscal Year: 2007
  10. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010

Detail Information

Publications146 found, 100 shown here

  1. pmc Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor V beta repertoire during experimental autoimmune encephalomyelitis
    H Jiang
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:8378-83. 2003
    ..Importantly, the T cell clones that expand in the absence of CD8+ T cell control are enriched in potentially pathogenic self-reactive T cell clones capable of inducing EAE in vivo...
  2. pmc Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size
    J L Matsuda
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 98:12636-41. 2001
    ..Each NKT clone is represented by only 5-10 cells. This clone size is similar to naive conventional T cells, and much lower than that reported for memory T cells, although NK T cells have an activated/memory phenotype...
  3. ncbi Genomic organization of the chicken T-cell receptor beta chain D-J-C region
    Akiko Shigeta
    Laboratory of Immunobiology, Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Hiroshima 739 8528, Japan
    J Vet Med Sci 66:1509-15. 2004
    ..Deletion of the 5'-end of Jbeta-1280 was particularly short when compared with that of Jbeta-1336, but there were no changes in the length of the CDR3 using any of the four Jbeta sequences...
  4. ncbi Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques
    David A Price
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 180:269-80. 2008
    ....
  5. pmc Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses
    Edwin R Manuel
    Beth Israel Deaconess Medical Center, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    J Virol 80:12032-40. 2006
    ....
  6. pmc Clonal focusing of epitope-specific CD8+ T lymphocytes in rhesus monkeys following vaccination and simian-human immunodeficiency virus challenge
    Pritha Sen
    Beth Israel Deaconess Medical Center, Division of Viral Pathogenesis, 330 Brookline Ave, Boston, MA 02215, USA
    J Virol 82:805-16. 2008
    ..Circumventing this restricted CD8(+) T-lymphocyte clonal diversity may present a significant challenge in the development of an effective HIV vaccine strategy...
  7. ncbi Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    Maria Ciofani
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    J Immunol 172:5230-9. 2004
    ..Collectively, our results demonstrate an essential role for Notch receptor-ligand interactions in enabling the autonomous signaling capacity of the pre-TCR complex...
  8. ncbi A survival guide to early T cell development
    Maria Ciofani
    Department of Immunology, University of Toronto, and Sunnybrook and Women s Research Institute, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Immunol Res 34:117-32. 2006
    ..In this review, we describe current concepts of the intracellular signaling pathways downstream of cell intrinsic and extrinsic factors that dictate survival versus death outcomes during early T cell development...
  9. pmc Maintenance of CD4+ T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, WMB rm 2337A, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Virology 369:324-8. 2007
    ....
  10. ncbi Organization, structure and evolution of 41kb of genomic DNA spanning the D-J-C region of the sheep TRB locus
    R Antonacci
    Dipartimento di Genetica e Microbiologia, Universita degli Studi di Bari, Italy
    Mol Immunol 45:493-509. 2008
    ..Closer inspections of the transcripts have also shown that inter-cluster rearrangements and splice variants, involving the additional cluster, increase the functional diversity of the sheep beta chain repertoire...
  11. ncbi Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 7/304, 7 Center Drive, Bethesda, MD 20892-0760, USA
    Leuk Res 25:719-33. 2001
    ..DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements...
  12. pmc The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion
    Chun Jeih Ryu
    Center for Cancer Research and Department of Biology, Massachusetts Institute for Technology, Cambridge, MA 02139, USA
    Mol Cell Biol 24:7015-23. 2004
    ..Although the promoter is dispensable for allelic exclusion, it appears to suppress aberrant V beta cleavages during allelic exclusion...
  13. ncbi Analysis of T-cell receptor BV gene sequences in cattle reveals extensive duplication within the BV9 and BV20 subgroups
    E F Houston
    Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, UK
    Immunogenetics 57:674-81. 2005
    ..However, duplication of different BV subgroups in cattle has resulted in a TRBV gene repertoire distinct from that found in other species...
  14. ncbi The T cell receptor beta locus of the channel catfish, Ictalurus punctatus, reveals unique features
    He Zhou
    Department of Microbiology, University of Mississippi Medical Center, Jackson, MS 39216 USA
    J Immunol 170:2573-81. 2003
    ..Taken together, compared with that in mammals, genomic sequencing of the catfish TCR DB-JB-CB region reveals a unique locus containing a greater number of JB genes and two distinct CB genes...
  15. pmc Boundary-independent polar nonsense-mediated decay
    Jun Wang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    EMBO Rep 3:274-9. 2002
    ..TCR genes may have evolved this unique NMD response because they frequently acquire nonsense codons during normal development...
  16. ncbi Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs
    Xuexian O Yang
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Blood 101:4492-9. 2003
    ....
  17. ncbi Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence
    Cherry Wu
    Howard Hughes Medical Institute, The Children s Hospital, Harvard University Medical School, Boston, MA 02115, USA
    Immunity 18:75-85. 2003
    ....
  18. ncbi Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
    Joshua T Mendell
    Institute of Genetic Medicine and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 858 Ross Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Science 298:419-22. 2002
    ..This provides compelling evidence that NAS relies on a component of the nonsense surveillance machinery but is not an indirect consequence of NMD...
  19. ncbi Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex
    Kenneth J Oestreich
    Department of Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Immunity 24:381-91. 2006
    ....
  20. ncbi Allele-specific regulation of TCR beta variable gene segment chromatin structure
    Annette M Jackson
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:5186-91. 2005
    ..These results suggest that a unique feedback mechanism may operate independent of chromatin structure to inhibit Vbeta to DJbeta recombination after the double-negative stage of thymocyte development...
  21. ncbi Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors
    Robert E Tillman
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Immunol 170:5-9. 2003
    ..These findings demonstrate that targeting of Vbeta to Dbeta rearrangement can be enforced by the V(D)J recombinase in the absence of lymphoid-specific factors other than the recombinase-activating gene-1/2 proteins...
  22. ncbi Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter
    C E Whitehurst
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 10:313-22. 1999
    ..These findings suggest that germline promoters regulate localized accessibility of gene segments for recombination and that in CD4+ CD8+ thymocytes TCR beta allelic exclusion does not result from inaccessibility of D beta gene segments...
  23. ncbi Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction
    Robert E Tillman
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Immunol Rev 200:36-43. 2004
    ..By preserving Dbeta gene segment utilization, the B12/23 restriction is required, at a minimum, for the generation of a diverse repertoire of TCRbeta chains...
  24. doi Use of a Pan-Vbeta primer permits the amplification and sequencing of TCRbeta chains expressed by bovine T-cell clones following a single semi-nested PCR reaction
    T Connelley
    Division of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, UK
    Vet Immunol Immunopathol 126:156-62. 2008
    ..This method offers a simple and rapid method of analyzing the TCRbeta chains of bovine T-cell clones that has many potential applications in the investigation of bovine T-cell responses...
  25. ncbi Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells
    David Jung
    Howard Hughes Medical Institute, The Children s Hospital, Harvard Medical School, Boston, MA, USA
    Immunity 18:65-74. 2003
    ..Our findings indicate that B12/23 restriction of V(D)J recombination is cemented at the level of interactions between the RAG proteins and TCRbeta RS sequences...
  26. ncbi Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition
    Xiaoming Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nat Immunol 9:794-801. 2008
    ..Our results show an unexpected function for c-Fos as a direct regulator of Tcrb recombination, rather than its usual function as a transcription regulator, and provide new insight into the mechanisms of recombination ordering...
  27. ncbi Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus
    I Aifantis
    Institut Necker, Institut National de la Santé et Recherche Medicale, 373, Paris, France
    Immunity 7:601-7. 1997
    ..Thus, the pre-TCR-independent suppression of rearrangement by TCR beta transgenes represents a transgene artifact, whereas under physiological conditions the pre-TCR is essential for allelic exclusion...
  28. ncbi Genomic sequencing of the bovine T cell receptor beta locus
    M L Conrad
    Department of Biology, Centre for Biomedical Research, P O Box 3020, University of Victoria, Victoria, BC, Canada V8W 3N5
    Vet Immunol Immunopathol 87:439-41. 2002
    ..The bovine beta locus appears to have a third constant region. Overall, the genomic characterization of the bovine TCR genes will provide insight into the evolution of T cell receptor...
  29. ncbi The human T cell receptor beta variable (TRBV) genes
    G Folch
    , CNRS, , Montpellier, France
    Exp Clin Immunogenet 17:42-54. 2000
    ..These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines. fr: 8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  30. pmc The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination
    Anna H Drejer-Teel
    Department of Genetics, Yale University School of Medicine, 330 Cedar St, New Haven, Connecticut 06510, USA
    Mol Cell Biol 27:6288-99. 2007
    ....
  31. ncbi In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Int Immunol 16:1549-59. 2004
    ....
  32. ncbi The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs
    Carlos Cantu
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:4673-82. 2003
    ..This suggests that there is less accommodation made by this TCR in recognizing alpha-galactosylceramide, and it can be assumed that the most rigid part of the Ag, the sugar moiety, is critical in the interaction...
  33. ncbi The four TCR genes of teleost fish: the cDNA and genomic DNA analysis of Japanese flounder (Paralichthys olivaceus) TCR alpha-, beta-, gamma-, and delta-chains
    Bo Hye Nam
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Minato, Tokyo, Japan
    J Immunol 170:3081-90. 2003
    ..This suggests that the flounder possesses very unique genomic DNA organization and gene loci for TCR, C alpha/C delta 1, and C gamma/C delta 2...
  34. ncbi Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex
    Ethan P Grant
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:3933-40. 2002
    ..Our findings indicate that the CDR loops of the TCR form the Ag recognition domain of CD1-restricted TCRs and suggest that the hydrophilic domains of a lipid Ag can form a combinatorial epitope recognized by the TCR...
  35. ncbi Blood T-cell Vbeta transcriptome in melanoma patients
    Nicolas Degauque
    Institut National de la Santé et de la Recherche Médicale Unité 437 Immunointervention dans les Allo et Xénotransplantations and Institut de Transplantation et de Recherche en Transplantation, Nantes, France
    Int J Cancer 110:721-9. 2004
    ..In combination with other methods, such an approach should help in identifying the clones actually involved in the response against the tumor...
  36. ncbi Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history
    Isabel Marcolino
    Institute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany
    Eur J Immunol 34:2672-80. 2004
    ..Thus, analysis of KLRG1 expression in cord blood revealed an unexpected heterogeneity of human T cells in newborns...
  37. ncbi Restricted T cell receptor BV gene usage in the lungs and muscles of patients with idiopathic inflammatory myopathies
    Pernilla Englund
    Karolinska University Hospital at Solna, and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 56:372-83. 2007
    ..To investigate T cell receptor (TCR) expression in 3 different compartments that could be involved in patients with myositis: muscle, lung, and peripheral blood...
  38. ncbi Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice
    Shohei Hori
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Eur J Immunol 32:3729-35. 2002
    ..These observations thus exclude peripheral differentiation of Treg in this particular system, and indicate that expansion of thymically committed cells ensures the maintenance of the peripheral Treg pool in the adult...
  39. ncbi T-cell receptor repertoire in healthy Sardinian subjects
    Silvana Bonfigli
    Institute of Hematology, University of Sassari, Sassari, Italy
    Hum Immunol 64:689-95. 2003
    ..Finally, the profound perturbations evidenced in the CD8+ T cell subpopulation could be related to a different response to the antigenic stimulation between CD8+ and CD4+ T lymphocytes...
  40. ncbi Functional T cells in primary immune response to histoplasmosis
    Jr Shiuan Lin
    Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
    Int Immunol 16:1663-73. 2004
    ..Our study laid the groundwork for further investigations in immune response to histoplasmosis...
  41. ncbi Determination of T-cell receptors of clonal CD8-positive T-cells in myelodysplastic syndrome with erythroid hypoplasia
    Takaji Matsutani
    Department of Medical Science, Discovery Research Laboratories, Shionogi and Co Ltd, Osaka 566 0022, Japan
    Leuk Res 27:305-12. 2003
    ....
  42. ncbi Expansion of specific alphabeta+ T-cell subsets in the myocardium of patients with myocarditis and idiopathic dilated cardiomyopathy associated with Coxsackievirus B infection
    Patrizia Luppi
    Department of Pediatrics, Division of Immunogenetics, University of Pittsburgh School of Medicine, PA, USA
    Hum Immunol 64:194-210. 2003
    ..This immune response may play a critical role in modulating disease progression after viral infections...
  43. ncbi Functionally impaired HIV-specific CD8 T cells show high affinity TCR-ligand interactions
    Takamasa Ueno
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    J Immunol 173:5451-7. 2004
    ..Taken together, these data indicate that impaired responsiveness of T cells toward HIV-infected cells can occur at the level of TCR-ligand interactions, providing us further insight into the immune evasion mechanisms by HIV...
  44. ncbi Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers
    Mineki Saito
    Department of Immunology, Imperial College London, St Mary s Campus, London, United Kingdom
    Blood 102:577-84. 2003
    ....
  45. pmc Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
    Scott M Lieberman
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:8384-8. 2003
    ..The human IGRP gene maps to a diabetes susceptibility locus, suggesting that IGRP also may be an antigen for pathogenic T cells in human type 1 diabetes and, thus, a new, potential target for diagnostic and therapeutic approaches...
  46. ncbi T cells in the lung of patients with hypersensitivity pneumonitis accumulate in a clonal manner
    Monica Facco
    Department of Clinical and Experimental Medicine, Clinical Immunology Branch, Padova, Italy
    J Leukoc Biol 75:798-804. 2004
    ..The evidence that identical T cell clones are present in the lung and the blood of the same patient suggests that the immune reaction occurring at lung level gives rise to a systemic reaction...
  47. pmc New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
    Willem A Dik
    Department of Immunology, Erasmus MC, 3015 GE Rotterdam, Netherlands
    J Exp Med 201:1715-23. 2005
    ..Our data demonstrate that a number of key events occur earlier than assumed previously; therefore, human T cell development is much more similar to murine T cell development than reported before...
  48. ncbi Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor
    Janet L Maryanski
    INSERM U503, IFR 128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    Immunol Res 30:231-40. 2004
    ..An intriguing explanation of our findings would be that only a very limited repertoire of TCR alpha-chains is selected to pair with a given TCR beta-chain during T-cell development...
  49. ncbi Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion
    Makoto Senoo
    Department of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Immunol 171:829-35. 2003
    ..These results provide strong evidence that increase of Vbeta accessibility influences frequency but not allelic exclusion of the TCR Vbeta rearrangement if the Vbeta gene is located in the Ebeta regulatory region...
  50. ncbi Follow-up of the T-cell clonality in Sezary patients treated by extracorporeal photopheresis using a new assay: the immunoscope technique
    Saskia Ingen-Housz-Oro
    Institut de Recherche sur la Peau, INSERM U532, Hopital, Saint Louis, Paris 75475, Cedex 10, France
    Transfus Apher Sci 28:35-42. 2003
    ..Immunoscope technique appears to be an efficient assay to appreciate the amount of tumoral cells and monitor the evolution of the clonal component in Sezary syndrome...
  51. ncbi Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysis
    Flavien Bernardin
    Department of Medicine, University of California, San Francisco, CA 94118, USA
    J Immunol Methods 274:159-75. 2003
    ....
  52. ncbi Application of the molecular analysis of the T-cell receptor repertoire in the study of immune-mediated hematologic diseases
    Magdalena Plasilova
    Experimental Hematology and Hematopoiesis Section, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH, R40, USA
    Hematology 8:173-81. 2003
    ....
  53. ncbi Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins
    Danielle A R Magalhães
    Molecular Immunogenetics Group, Department of Genetics, Faculty of Medicine, University of Sao Paulo USP, 14040 900 Ribeirão Preto, SP, Brazil
    Mol Immunol 42:1043-8. 2005
    ....
  54. ncbi T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction
    Maureen M Hughes
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis 63110, USA
    Eur J Immunol 33:1568-75. 2003
    ..Rather, this distribution is determined primarily at the level of variable-region gene assembly, and is critically dependent on unique features of the V(D)J recombination reaction that ensure Dbeta gene segment utilization...
  55. ncbi Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous T-cell lymphoma: diagnostic and prognostic implications
    Chalid Assaf
    Department of Dermatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Blood 105:503-10. 2005
    ..Thus, T-cell clonality analysis is an important adjunct in differentiating benign dermatopathic lymphadenitis from early CTCL involvement...
  56. ncbi Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery
    Gisela M Vaitaitis
    Department of Medicine and Webb Waring Institute for Cancer, Aging and Antioxidant Research, University of Colorado, Denver, CO 80262, USA
    J Immunol 170:3455-9. 2003
    ..Therefore, CD40-regulated expression of RAG1 and RAG2 in peripheral T cells may constitute a novel pathway for the generation of autoaggressive T cells...
  57. ncbi Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
    Yasutoshi Agata
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Immunity 27:871-84. 2007
    ..Thus, the abundance of E47 is rate limiting in locus activation, and feedback signaling downregulates E47 activity to ensure allelic exclusion...
  58. ncbi Extensive clonal expansion of T lymphocytes causes contracted diversity of complementarity-determining region 3 and skewed T cell receptor repertoires after allogeneic hematopoietic cell transplantation
    M Hirokawa
    Department of Internal Medicine III, Akita University School of Medicine, Akita, Japan
    Bone Marrow Transplant 27:607-14. 2001
    ....
  59. ncbi Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development
    H D Lacorazza
    Laboratory of T Cell Development, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 166:3184-93. 2001
    ....
  60. ncbi Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes
    A Quinn
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 166:2982-91. 2001
    ....
  61. pmc Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood
    David van Bockel
    Centre for Immunology, St Vincent s Hospital, Sydney, NSW, Australia
    J Immunol Methods 326:127-38. 2007
    ....
  62. pmc Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray
    Xujing Wang
    The Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, The Medical College of Wisconsin and The Children s Hospital Research Institute of Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    BMC Genomics 8:329. 2007
    ..We have used the memory T cell repertoire to an influenza-derived peptide as a test case for developing such a method...
  63. ncbi Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance
    V M Lentz
    Department of Microbiology and Immunology, Jefferson Medical College, BLSB 708, 233 South 10th Street, Philadelphia, PA 19107, USA
    Int Immunol 12:1483-97. 2000
    ..Collectively, our data support the idea that T cells play a multifaceted role in the maintenance of peripheral B cell tolerance that includes mediating the activation-induced death of autospecific B cells...
  64. ncbi Multiple sclerosis: T-cell receptor expression in distinct brain regions
    Andreas Junker
    Institute for Clinical Neuroimmunology, Ludwig Maximilians University, D 81377 Munich, Germany
    Brain 130:2789-99. 2007
    ..These experiments revealed that at least some of the pervasive T-cell clones belonged to the CD8+ compartment, supporting the pathogenic relevance of this T-cell subset...
  65. ncbi Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes
    Richard M Coles
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia
    Eur J Immunol 33:1557-67. 2003
    ..Therefore, the ability to bind soluble MHC-peptide complexes does not always correlate with the ability of a T cell to respond to its cognate antigen after in vivo stimulation...
  66. ncbi Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping
    H Soudeyns
    Laboratoire d Immunologie, Institut de Recherches Cliniques de Montreal, McGill University, Montreal, Canada
    J Infect Dis 181:107-20. 2000
    ....
  67. pmc Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion
    J Biro
    Max Planck Institut fur Immunbiologie, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 96:3882-7. 1999
    ..The data suggest that signaling through clonotype-independent CD3 complexes may contribute to allelic exclusion of the TCRbeta locus by inducing the expression of rearranged TCRbeta genes in CD25(+) DN thymocytes...
  68. ncbi Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome
    Giuseppe Guida
    Allergologia e Immunologia Clinica, University of Torino Medical School, Italy
    Clin Immunol 128:94-102. 2008
    ..All CD8+ expansions were detectable throughout the disease course. TCR-Vbeta expanded or deleted populations were not observed in asthmatic patients. Clonal CD8+/Vbeta+ T cell expansions might be useful as a disease marker...
  69. ncbi Persistence of dominant T cell clones in accepted solid organ transplants
    C Baron
    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 167:4154-60. 2001
    ..Collectively, these data represent the first example, in a preclinical model, of the emergence of nonaggressive intragraft clones, which may be involved in the induction/maintenance of local tolerance to allogeneic tissues...
  70. pmc E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression
    Jason Wojciechowski
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:5717-26. 2007
    ..These results suggest that E2A and HEB are not only critical for T cell differentiation but also necessary to retain developing thymocytes in cell cycle arrest before pre-TCR expression...
  71. ncbi Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
    Jane A Skok
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Nat Immunol 8:378-87. 2007
    ..Hence, pericentromeric recruitment and locus 'decontraction' seem to contribute to the initiation and maintenance of allelic exclusion at the Tcrb locus...
  72. pmc The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement
    F Davodeau
    INSERM U.463, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France
    EMBO J 20:4717-29. 2001
    ....
  73. ncbi CD3+CD4-CD8+NK- large granular lymphocytosis with neutropenia and evidence for clonality and T-cell receptor gene rearrangement: two pediatric cases
    Mamidipudi T Krishna
    Department of Immunology, Southampton General Hospital, Southampton, UK
    J Pediatr Hematol Oncol 24:495-8. 2002
    ..Immunosuppressive therapy in the two children described in this report resulted in improvement of neutropenia and clinical status, but this was not accompanied by the disappearance of the clonal population...
  74. ncbi A prospective study on the evolution of the T-cell repertoire in patients with Sézary syndrome treated by extracorporeal photopheresis
    Saskia Ingen-Housz-Oro
    Institut de Recherche sur la Peau, Institut National de la Santé et de la Recherche Médicale INSERM U532, Hopital Saint Louis, 75475 Paris, France
    Blood 100:2168-74. 2002
    ..The immunoscope technique appears to be an efficient tool to appreciate the amount of tumoral cells and to monitor the evolution of the clonal component in the Sézary syndrome...
  75. ncbi Clonal CD8+ T cell expansions in peripheral blood from human immunodeficiency virus type 1-infected children
    Elizabeth J McFarland
    Division of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 186:477-85. 2002
    ..Children with expansions were not more likely to have increased numbers of CD8(+) T cells, a finding consistent with the possibility that the CD8(+) TCR repertoire has limited diversity...
  76. pmc Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
    Felix J Baker
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:9374-9. 2002
    ..Thus, autoimmune diabetes in NOD may be initiated by a limited number of antigens distinct from GAD65 and insulin...
  77. ncbi Emergence of TCR alpha/beta V(D)J recombination and transcription during ontogeny of inbred mouse strains
    C M Junta
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Mol Cell Biochem 187:67-72. 1998
    ..The transcriptions of these loci followed respective recombinations and we detected an early germline transcript before TCR beta locus recombination in the CBA strain...
  78. ncbi Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivity
    Danila Valmori
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, and Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland
    J Immunol 168:4231-40. 2002
    ..Collectively, these data show that tumor peptide-driven immune stimulation leads to the selection of high-avidity T cell clones of increased tumor reactivity that independently evolve within oligoclonal populations...
  79. ncbi Restricted T-cell receptor beta-chain usage by T cells autoreactive to beta(2)-glycoprotein I in patients with antiphospholipid syndrome
    Kazue Yoshida
    Institute for Advanced Medical Research, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Blood 99:2499-504. 2002
    ..Our results indicate preferential usage of TCRbeta chains by beta(2)GPI-reactive T cells. These TCRbeta chains can be reasonable targets for TCR-based immunotherapy for patients with APS...
  80. ncbi Reconstitution of the T-cell repertoire following treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia
    Mohammad Reza Rezvany
    Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Cancer Centre Karolinska CCK, Karolinska Institutet, Stockholm, Sweden
    Br J Haematol 135:475-85. 2006
    ..These results indicate that perturbations in the T-cell alterations following alemtuzumab are complex and include not only changes in CD4/CD8 T-cell numbers but also a highly restricted T-cell repertoire especially in CD4 T cells...
  81. ncbi Analysis of the CDR3 region of alpha/beta T-cell receptors (TCRs) and TCR BD gene double-stranded recombination signal sequence breaks end in peripheral blood mononuclear cells of T-lineage acute lymphoblastic leukemia
    Y Xin-Sheng
    Institute of Molecular Immunology, Southern Medical University, Guangzhou 510515, China
    Clin Lab Haematol 28:405-15. 2006
    ..This information will also be helpful in exploring new immunological pathogenesis and facilitating the design of a T-ALL vaccine, as well as in improving our understanding of healthy human T-cell development...
  82. ncbi CD4 promotes breadth in the TCR repertoire
    Q Wang
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 167:4311-20. 2001
    ..The data thus suggest a key role for CD4 in broadening the TCR repertoire by potentiating productive TCR signaling and clonal expansion in response to the engagement of low-affinity antigenic ligands...
  83. ncbi Distinct and non-overlapping T cell receptor repertoires expanded by DNA vaccination in wild-type and HER-2 transgenic BALB/c mice
    Simona Rolla
    Dipartimento di Scienze Cliniche e Biologiche, University of Turin, Turin, Italy
    J Immunol 177:7626-33. 2006
    ..This definition of the T cell repertoires available is critical to the designing of immunological maneuvers able to elicit an effective immune reaction against HER-2-driven carcinogenesis...
  84. pmc Limited heterogeneity of T cell receptor BV usage in aplastic anemia
    W Zeng
    Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    J Clin Invest 108:765-73. 2001
    ....
  85. pmc Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts
    Ichiro Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 86:601-10. 2008
    ..In this study, we assessed the diversity of the human T cell repertoire generated in porcine thymic xenografts. We also examined the ability of porcine thymus grafts to coexist with human thymus grafts...
  86. ncbi Characterization of T cell receptor beta chains of accumulating T cells in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice
    H Nakamura
    The Department of Medical Bioregulation, Yamaguchi University School of Medicine, Ube, Japan
    Jpn Circ J 65:106-10. 2001
    ..To characterize the accumulating T cells in the donor heart, the T cell receptor beta genes (TCRBG) were amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) from mRNA in the ..
  87. pmc Organization of human T-cell receptor beta-chain genes: clusters of V beta genes are present on chromosomes 7 and 9
    M A Robinson
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852
    Proc Natl Acad Sci U S A 90:2433-7. 1993
    ..These results indicate that the functional germ-line V beta repertoire in humans is substantially (10%) smaller than previously estimated...
  88. ncbi Germline organization of the murine T cell receptor beta-chain genes
    H S Chou
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Science 238:545-8. 1987
    ..The large distance between V beta and D beta, relative to that between D beta and J beta, may have significant implications for the ordered rearrangement of the T cell receptor beta-chain genes...
  89. ncbi Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes
    S J Anderson
    Howard Hughes Medical Institute, University of Washington School of Medicine, SL 15, Seattle 98195
    Nature 365:552-4. 1993
    ..Here we confirm this prediction through examination of allelic exclusion in mice expressing both a functional TCR beta chain transgene and a catalytically inactive form of p56lck...
  90. ncbi Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region
    M Stewart
    Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Bearsden, Glasgow, UK
    Int J Cancer 53:1023-30. 1993
    ..The CD2-myc mouse should therefore be a valuable system in screening for novel myc-collaborating genes involved in T-cell lymphoma...
  91. pmc T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Immunol Methods 354:40-4. 2010
    ..This technique as well as other dried blood spot based technologies could increase the diagnostic and monitoring capabilities in resource-limited settings...
  92. pmc Nonsense-associated alternative splicing of T-cell receptor beta genes: no evidence for frame dependence
    Fabio Mohn
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH 3012 Bern, Switzerland
    RNA 11:147-56. 2005
    ..Our study thus contradicts the previously reported PTC specificity of TCR-beta NAS and points out the need for systematically testing the PTC specificity in other cases where NAS has been observed...
  93. ncbi Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease
    C A Kappel
    Tumor Cell Biology Program, Northwestern University Medical School, Chicago, IL 60611
    J Immunol 147:4322-6. 1991
    ..S congenic mice. These results strongly suggest the presence of a hierarchy of genes involved in the immune response in Theiler's murine encephalomyelitis virus-induced demyelinating disease...
  94. ncbi Anaplastic large-cell lymphomas of T-cell and null-cell phenotype express cytotoxic molecules
    H D Foss
    Institute of Pathology, Klinikum Benjamin Franklin, Free University of Berlin, Germany
    Blood 88:4005-11. 1996
    ....
  95. ncbi The T cell receptor beta genes of Xenopus
    I Chretien
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:763-71. 1997
    ..The locus is inherited in a diploid manner despite the pseudotetraploidy of the Xenopus laevis and X. gilli used in this study...
  96. ncbi Clonally expanded T-cells in the peripheral blood of patients with idiopathic Thrombocytopenic purpura and Helicobacter pylori infection
    Midori Ishiyama
    Department of Haematology, Tokyo Women s Medical University, Japan
    Int J Hematol 83:147-51. 2006
    ..These findings suggest that specific T-cell clones accumulate in H pylori-related ITP and that such clones may be associated with immune-mediated destruction of platelets...
  97. ncbi Regulation of immunoglobulin heavy-chain gene rearrangements
    Dipanjan Chowdhury
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Immunol Rev 200:182-96. 2004
    ..VH genes are activated subsequently and, in part, by interleukin-7. These observations lead to a model for feedback inhibition of IgH rearrangements...
  98. ncbi Complexity of human T-cell antigen receptor beta-chain constant- and variable-region genes
    J E Sims
    Nature 312:541-5. 1984
    ..The gene arrangement, analogous to that of mouse beta-chain genes, shows strong evolutionary conservation of the dual C beta gene system in these two species...
  99. pmc Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens
    S Adams
    Department of Medicine, New England Medical Center, Boston, MA 02111
    Proc Natl Acad Sci U S A 88:11271-5. 1991
    ..These results offer a clue regarding the nature of the primary autoantigen that may drive the pathogenic autoimmune response in lupus...
  100. ncbi Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients
    D Valmori
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital, Switzerland
    J Immunol 165:533-8. 2000
    ..Together, these results suggest that a large and diverse repertoire of Melan-A-specific T cells using different BV TCR segments is available in A2 melanoma patients...
  101. ncbi Flexibility in MHC and TCR recognition: degenerate specificity at the T cell level in the recognition of promiscuous Th epitopes exhibiting no primary sequence homology
    S K Joshi
    Malaria Research Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Immunol 166:6693-703. 2001
    ....

Research Grants82

  1. MOLECULAR PATHOLOGY OF LEUKEMIA/LYMPHOID MARKER
    KAREN CHANCELLOR; Fiscal Year: 1992
    ..N regions (extra random nucleotides) to DNA during rearrangement of immunoglobulin heavy chain genes or T cell receptor beta genes. Recently, cDNAs coding for human terminal transferase have been cloned and used to isolate the gene ..
  2. MOLECULAR PATHOLOGY OF LEUKEMIA/LYMPHOID MARKER
    KAREN CHANCELLOR; Fiscal Year: 1993
    ..N regions (extra random nucleotides) to DNA during rearrangement of immunoglobulin heavy chain genes or T cell receptor beta genes. Recently, cDNAs coding for human terminal transferase have been cloned and used to isolate the gene ..
  3. ALLOGENEIC RESPONSE:ROLE OF T CELL RECEPTOR DIVERSITY
    Carolyn Hurley; Fiscal Year: 1990
    ....
  4. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2007
    ..Mutations at V:C and Va:V[unreadable] interfaces will be introduced into a T cell transfection system to examine their possible influence on T cell activation. [unreadable] [unreadable]..
  5. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  6. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY BURROWS; Fiscal Year: 2007
    ..The work proposed will provide a solid base for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. [unreadable] [unreadable] [unreadable]..
  7. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2007
    ..Lastly, the most precious result will be the "understanding" that is uniquely derived from the availability of an integrative and predictive analytical tool. ..
  8. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. HLA-DQ-derived RTLs for Treatment of Celiac Disease
    GREGORY BURROWS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  11. Human MHC Class II Constructs For Autoimmume Therapy
    GREGORY BURROWS; Fiscal Year: 2004
    ..Understanding how these unique, rationally engineered drugs work will provide a solid foundation for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  12. T CELL RESPONSES TO LOW AFFINITY LIGANDS FOR THE TCR
    GILBERT KERSH; Fiscal Year: 2005
    ..The results of these experiments will contribute significantly to a molecular understanding of T-cell responses to low affinity ligands. ..
  13. Human MHC Class II Constructs For Autoimmume Therapy
    GREGORY BURROWS; Fiscal Year: 2005
    ..Understanding how these unique, rationally engineered drugs work will provide a solid foundation for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  14. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2005
    ..Lastly, the most precious result will be the "understanding" that is uniquely derived from the availability of an integrative and predictive analytical tool ..
  15. IMMUNOREGULATION IN AIDS
    Norman Letvin; Fiscal Year: 2006
    ..3. Nondominant SHIV epitope-specific CTL populations. A. Breadth and magnitude. B. Functional repertoire. C. TCR repertoire. 4. Nondominant epitope-specific CTL and control of SIV replication. [unreadable] [unreadable]..
  16. Sex steroids and the thymus
    GILBERT KERSH; Fiscal Year: 2006
    ..abstract_text> ..
  17. Receptor-Based Therapeutics for Enterotoxins
    DAVID KRANZ; Fiscal Year: 2006
    ....
  18. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2006
    ..Mutations at V:C and Va:V[unreadable] interfaces will be introduced into a T cell transfection system to examine their possible influence on T cell activation. [unreadable] [unreadable]..
  19. CD8+ T Cells Control Autoimmunity In EAE
    Hong Jiang; Fiscal Year: 2007
    ..Thus, the studies will provide theoretical basis for clinical application of this regulatory pathway in prevention and treatment of multiple sclerosis in man. [unreadable] [unreadable] [unreadable]..
  20. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  21. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY GEORGE BURROWS; Fiscal Year: 2010
    ..Evaluation of the in vivo effects RTLs have on relapsing-remitting and chronic models of EAE. The work proposed will provide a solid base for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  22. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2010
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  23. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  24. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY BURROWS; Fiscal Year: 2009
    ..Evaluation of the in vivo effects RTLs have on relapsing-remitting and chronic models of EAE. The work proposed will provide a solid base for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  25. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2009
    ..Mutations at V:C and Va:Vp interfaces will be introduced into a T cell transfection system to examine their possible influence on T cell activation. ..
  26. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  27. Receptor-Based Therapeutics for Enterotoxins
    DAVID KRANZ; Fiscal Year: 2009
    ....
  28. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2008
    ..Lastly, the most precious result will be the "understanding" that is uniquely derived from the availability of an integrative and predictive analytical tool. ..
  29. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  31. Regulation of Progenitor Entry into the Thymus
    GILBERT KERSH; Fiscal Year: 2008
    ..This study explores the regulation of thymus size so that it might be possible to enhance thymus function after induced immune deficiency. [unreadable] [unreadable] [unreadable]..
  32. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY BURROWS; Fiscal Year: 2008
    ..Evaluation of the in vivo effects RTLs have on relapsing-remitting and chronic models of EAE. The work proposed will provide a solid base for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  33. Integrative genomics to to dissect the genetic regulation of T1D onset
    Xujing Wang; Fiscal Year: 2007
    ..The management of T1D is difficult particularly in the young, and in recent decades incidence in the young is rising rapidly. ..
  34. Receptor-Based Therapeutics for Enterotoxins
    DAVID KRANZ; Fiscal Year: 2008
    ....
  35. Structure, Function and Engineering of T Cell Receptors
    DAVID KRANZ; Fiscal Year: 2008
    ..Mutations at V:C and Va:Vp interfaces will be introduced into a T cell transfection system to examine their possible influence on T cell activation. ..
  36. DNA VACCINE IMMUNITY TO HIV1 AND SIV
    Norman Letvin; Fiscal Year: 2002
    ..This aim therefore studies cross reactivity to a single epitope not multi epitopes. ..
  37. DNA VACCINE IMMUNITY TO HIV1 AND SIV
    Norman Letvin; Fiscal Year: 1999
    ..This aim therefore studies cross reactivity to a single epitope not multi epitopes. ..
  38. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....
  39. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2008
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  40. Human MHC Class II Constructs For Autoimmume Therapy
    GREGORY BURROWS; Fiscal Year: 2001
    ..Understanding how these unique, rationally engineered drugs work will provide a solid foundation for pharmacological intervention in CD4+ T cell mediated autoimmune diseases. ..
  41. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  42. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  43. NOVEL MHC CLASS II CONSTRUCTS FOR TREATMENT OF EAE
    GREGORY BURROWS; Fiscal Year: 2001
    ..abstract_text> ..
  44. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2001
    ....
  45. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 1991
    ..Third, the skeleton of a computerized interactive immune response has been formulated and needs to be refined to incorporate the detailed component outputs of the humoral and cell mediated immune response compartments...
  46. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2000
    ..abstract_text> ..
  47. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1999
    ....
  48. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2002
    ..abstract_text> ..
  49. IMMUNOREGULATION IN AIDS
    Norman Letvin; Fiscal Year: 2004
    ..C. Fitness relative to wild type viruses. 3. Nondominant SHIV epitope-specific CTL populations. A. Breadth and magnitude. B. Functional repertoire. C. TCR repertoire. 4. Nondominant epitope-specific CTL and control of SIV replication. ..
  50. Structure, Function & Engineering of Tau Cell Receptors
    DAVID KRANZ; Fiscal Year: 2003
    ..The latter studies will include further use of these TCR to improve the sensitivity in detection of pMHC on antigen-presenting cells and as immunosuppressants of T cell activation. ..
  51. CD8+ T CELL RECOGNITION OF TH1 AND TH2
    Hong Jiang; Fiscal Year: 2003
    ..We will determine if this difference uniquely applies to the recognition of TCR peptide presented by Qa-1 or if CD8+ T cells specific for other peptides presented by MHC class I molecules also distinguish between TH1 and TH2 targets. ..
  52. Human Resistance to Herpes Simplex Virus Infections
    Christine Posavad; Fiscal Year: 2002
    ..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..
  53. PATHOGENIC T CELLS IN BERYLLIUM-INDUCED LUNG DISEASE
    ANDREW FONTENOT; Fiscal Year: 2002
    ..Additional studies will examine whether antigen processing is required for stimulation of these T cell hybridomas. Together, these studies will provide new insight into the immunopathogenesis of CBD and other granulomatous disorders. ..
  54. STRUCTURE/FUNCTION AND ENGINEERING OF T CELL RECEPTORS
    DAVID KRANZ; Fiscal Year: 2000
    ..Mutants will be characterized for binding affinities and inhibition of T cell recognition. ..
  55. Structure, Function & Engineering of Tau Cell Receptors
    DAVID KRANZ; Fiscal Year: 2002
    ..The latter studies will include further use of these TCR to improve the sensitivity in detection of pMHC on antigen-presenting cells and as immunosuppressants of T cell activation. ..
  56. CD8+ T Cells Control Autoimmunity In EAE
    Hong Jiang; Fiscal Year: 2006
    ..Thus, the studies will provide theoretical basis for clinical application of this regulatory pathway in prevention and treatment of multiple sclerosis in man. [unreadable] [unreadable] [unreadable]..
  57. Receptor-Based Therapeutics for Enterotoxins
    DAVID KRANZ; Fiscal Year: 2007
    ....
  58. Conference HIV Vaccine Development Progress & Prospects
    Norman Letvin; Fiscal Year: 2004
    ..abstract_text> ..
  59. Role of Cytokines and Autoimmunity in Murine BA
    Cara Mack; Fiscal Year: 2005
    ..Defining the immunopathology in biliary atresia will lead to a better understanding of the etiopathogenesis and provide insight into future therapeutic options. ..
  60. STRUCTURE/FUNCTION AND ENGINEERING OF T CELL RECEPTORS
    DAVID KRANZ; Fiscal Year: 1999
    ..Mutants will be characterized for binding affinities and inhibition of T cell recognition. ..
  61. Human Resistance to Herpes Simplex Virus Infections
    Christine Posavad; Fiscal Year: 2005
    ..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..
  62. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2003
    ..abstract_text> ..
  63. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2003
    ....
  64. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 2009
    ..These basic questions are important for the design of vaccines with high efficacy. ..
  65. T Cell-Mediated Mechanisms of Autoimmunity in Murine and Human Biliary Atresia
    Cara Mack; Fiscal Year: 2007
    ..The overall goal of this research program is to use these molecular and immunological insights as a basis for development of future therapeutic and preventative strategies for this important disease. ..
  66. POLYOMAVIRUS INFECTION IN IMMUNODEFICIENT MICE
    Eva Szomolanyi Tsuda; Fiscal Year: 1999
    ..Polyoma is non-pathogenic in its immunocompetant natural host. Studying its pathogenesis in immunodeficient hosts can provide basic information which can help to understand processes induced by viruses in immunocompromised individuals. ..
  67. IMMUNOREGULATION IN AIDS
    Norman Letvin; Fiscal Year: 2007
    ..3. Nondominant SHIV epitope-specific CTL populations. A. Breadth and magnitude. B. Functional repertoire. C. TCR repertoire. 4. Nondominant epitope-specific CTL and control of SIV replication. [unreadable] [unreadable]..
  68. ENGINEERING SINGLE CHAIN ANTI T CELL RECEPTOR ANTIBODIES
    DAVID KRANZ; Fiscal Year: 2002
    ..This system involves the use of yeast that we have already engineered to display surface scFv-KJ16. Yeast that co-express scFv-KJ16 and scFv-4F10 will be tested for their ability to affect T cell activity in vitro. ..
  69. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2001
    ..abstract_text> ..
  70. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 1993
    ..Third, the skeleton of a computerized interactive immune response has been formulated and needs to be refined to incorporate the detailed component outputs of the humoral and cell mediated immune response compartments...
  71. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 1999
    ..can be monitored. By specifying the events (e.g.; expansion of an entity, elimination of an entity), and probability of such changes based on a desired parameter, rudimentary aspects of the a model's predictions can be approximated. ..
  72. Structure, Function & Engineering of Tau Cell Receptors
    DAVID KRANZ; Fiscal Year: 2001
    ..The latter studies will include further use of these TCR to improve the sensitivity in detection of pMHC on antigen-presenting cells and as immunosuppressants of T cell activation. ..
  73. Polyomavirus Infection in Immunodedicient Mice
    Eva Szomolanyi Tsuda; Fiscal Year: 2006
    ..These basic questions are important for the design of vaccines with high efficacy. ..