quantitative trait loci

Summary

Summary: Locations, on the GENOME, of GENES or other genetic elements that encode or control the expression of a quantitative trait (QUANTITATIVE TRAIT, HERITABLE).

Top Publications

  1. pmc Understanding mechanisms underlying human gene expression variation with RNA sequencing
    Joseph K Pickrell
    Department of Human Genetics, The University of Chicago, Chicago 60637, USA
    Nature 464:768-72. 2010
  2. pmc Transcriptome genetics using second generation sequencing in a Caucasian population
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211 Switzerland
    Nature 464:773-7. 2010
  3. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  4. ncbi TASSEL: software for association mapping of complex traits in diverse samples
    Peter J Bradbury
    United States Department of Agriculture Agricultural Research Service, Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Bioinformatics 23:2633-5. 2007
  5. pmc Variance component model to account for sample structure in genome-wide association studies
    Hyun Min Kang
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 42:348-54. 2010
  6. pmc The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 7:e1002003. 2011
  7. doi Genome-wide association studies of 14 agronomic traits in rice landraces
    Xuehui Huang
    National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Genet 42:961-7. 2010
  8. pmc Mapping the genetic architecture of gene expression in human liver
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington, United States of America
    PLoS Biol 6:e107. 2008
  9. pmc Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
    Dan L Nicolae
    Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 6:e1000888. 2010
  10. pmc DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    Jordana T Bell
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Genome Biol 12:R10. 2011

Research Grants

Detail Information

Publications347 found, 100 shown here

  1. pmc Understanding mechanisms underlying human gene expression variation with RNA sequencing
    Joseph K Pickrell
    Department of Human Genetics, The University of Chicago, Chicago 60637, USA
    Nature 464:768-72. 2010
    ..in gene expression is a central goal of both medical and evolutionary genetics, and studies of expression quantitative trait loci (eQTLs) have become an important tool for achieving this goal...
  2. pmc Transcriptome genetics using second generation sequencing in a Caucasian population
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211 Switzerland
    Nature 464:773-7. 2010
    ..Correlation with SNPs (small nucleotide polymorphisms) leads to a larger discovery of eQTLs (expression quantitative trait loci) than with arrays...
  3. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
    R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental populations derived from inbred lines...
  4. ncbi TASSEL: software for association mapping of complex traits in diverse samples
    Peter J Bradbury
    United States Department of Agriculture Agricultural Research Service, Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Bioinformatics 23:2633-5. 2007
    ..Other features include analyzing insertions/deletions, calculating diversity statistics, integration of phenotypic and genotypic data, imputing missing data and calculating principal components...
  5. pmc Variance component model to account for sample structure in genome-wide association studies
    Hyun Min Kang
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA
    Nat Genet 42:348-54. 2010
    ..We find that EMMAX outperforms both principal component analysis and genomic control in correcting for sample structure...
  6. pmc The architecture of gene regulatory variation across multiple human tissues: the MuTHER study
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 7:e1002003. 2011
    ..Our results underline the need to account for the complexity of eQTL tissue-specificity in an effort to assess consequences of such variants for complex traits...
  7. doi Genome-wide association studies of 14 agronomic traits in rice landraces
    Xuehui Huang
    National Center for Gene Research, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Genet 42:961-7. 2010
    ....
  8. pmc Mapping the genetic architecture of gene expression in human liver
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington, United States of America
    PLoS Biol 6:e107. 2008
    ..We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process...
  9. pmc Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
    Dan L Nicolae
    Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 6:e1000888. 2010
    ....
  10. pmc DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    Jordana T Bell
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Genome Biol 12:R10. 2011
    ..Here we measured methylation levels at 22,290 CpG dinucleotides in lymphoblastoid cell lines from 77 HapMap Yoruba individuals, for which genome-wide gene expression and genotype data were also available...
  11. pmc Common regulatory variation impacts gene expression in a cell type-dependent manner
    Antigone S Dimas
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1HH, Cambridge, UK
    Science 325:1246-50. 2009
    ..80% of regulatory variants operating in a cell type-specific manner, and identified multiple expressive quantitative trait loci (eQTLs) per gene, unique or shared among cell types and positively correlated with the number of ..
  12. pmc High-resolution mapping of expression-QTLs yields insight into human gene regulation
    Jean Baptiste Veyrieras
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    PLoS Genet 4:e1000214. 2008
    Recent studies of the HapMap lymphoblastoid cell lines have identified large numbers of quantitative trait loci for gene expression (eQTLs)...
  13. doi The genetic architecture of maize flowering time
    Edward S Buckler
    U S Department of Agriculture USDA Agricultural Research Service USDA ARS, USA
    Science 325:714-8. 2009
    ..a million plants were assayed in eight environments but showed no evidence for any single large-effect quantitative trait loci (QTLs)...
  14. pmc Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    Chiara Sabatti
    Department of Human Genetics and Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 41:35-46. 2009
    ..The association observed between low-density lipoprotein and an infrequent variant in AR suggests the potential of such a cohort for identifying associations with both common, low-impact and rarer, high-impact quantitative trait loci.
  15. pmc Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
    ....
  16. doi Mapping complex disease traits with global gene expression
    William Cookson
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Nat Rev Genet 10:184-94. 2009
    ..Although there are limitations to current eQTL maps, understanding of disease will be enhanced with novel technologies and international efforts that extend to a wide range of new samples and tissues...
  17. pmc Development and characterization of a high density SNP genotyping assay for cattle
    Lakshmi K Matukumalli
    Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 4:e5350. 2009
    ..use of large-scale high-density single nucleotide polymorphism (SNP) genotyping for the identification of quantitative trait loci (QTL) and for marker-assisted selection in model and agricultural species...
  18. pmc Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
    J Raphael Gibbs
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000952. 2010
    ..We find an abundance of genetic cis regulation of mRNA expression and show for the first time abundant quantitative trait loci for DNA CpG methylation across the genome...
  19. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  20. pmc Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA
    Rudolf S N Fehrmann
    Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS Genet 7:e1002197. 2011
    ..Therefore, these trans-eQTLs could well represent some of the intermediate genes that connect genetic variants with their eventual complex phenotypic outcomes...
  21. pmc DNase I sensitivity QTLs are a major determinant of human expression variation
    Jacob F Degner
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nature 482:390-4. 2012
    The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool for linking genetic variation to changes in gene regulation...
  22. doi A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    Yoon Shin Cho
    Center for Genome Science, National Institute of Health, Seoul, Korea
    Nat Genet 41:527-34. 2009
    ..2 x 10(-3), P = 1.4 x 10(-7) and P = 6.0 x 10(-4), respectively). This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways...
  23. ncbi A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    Alex Clop
    Unit of Animal Genomics, Department of Animal Production, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege, Belgium
    Nat Genet 38:813-8. 2006
    ..Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation...
  24. pmc Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals
    Jun Ding
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109, USA
    Am J Hum Genet 87:779-89. 2010
    ....
  25. pmc Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e14726. 2011
    ..The recent completion of the swine genome sequencing project and development of a high density porcine SNP array has made genome-wide association (GWA) studies feasible in pigs...
  26. pmc Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression
    Jingyuan Fu
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS Genet 8:e1002431. 2012
    ..6×10(-10)). Our study yields new insights into the genetic basis of tissue-dependent expression and suggests that complex trait associated genetic variants have even more complex regulatory effects than previously anticipated...
  27. doi Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  28. pmc Extension of the bayesian alphabet for genomic selection
    David Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    BMC Bioinformatics 12:186. 2011
    ..The methods were compared in terms of inference of the number of QTL and accuracy of genomic estimated breeding values (GEBVs), using simulated scenarios and real data from North American Holstein bulls...
  29. pmc Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits
    Ben J Hayes
    Biosciences Research Division, Department of Primary Industries Victoria, Melbourne, Victoria, Australia
    PLoS Genet 6:e1001139. 2010
    ....
  30. doi Genome-wide association study of leaf architecture in the maize nested association mapping population
    Feng Tian
    Institute for Genomic Diversity, Cornell University, Ithaca, New York, USA
    Nat Genet 43:159-62. 2011
    ..These results demonstrate that the use of GWAS with specially designed mapping populations is effective in uncovering the basis of key agronomic traits...
  31. pmc Identification of several small main-effect QTLs and a large number of epistatic QTLs for drought tolerance related traits in groundnut (Arachis hypogaea L.)
    K Ravi
    International Crops Research Institute for the Semi Arid Tropics, Patancheru, India
    Theor Appl Genet 122:1119-32. 2011
    ..This study suggests deployment of modern approaches like marker-assisted recurrent selection or genomic selection instead of marker-assisted backcrossing approach for breeding for drought tolerance in groundnut...
  32. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
    ..Our method should have broad applications in yeast and can be extended to other organisms...
  33. doi Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
    ..By performing expression QTL analyses, we identified a splice site variant in CHCHD7 and exploited this naturally occurring null allele to exclude CHCHD7 as single causative gene...
  34. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    ..Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity...
  35. pmc A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping
    Tom Druet
    Unit of Animal Genomics, GIGA Research and Department of Animal Production, Faculty of Veterinary Medicine, University of Liege, Belgium
    Genetics 184:789-98. 2010
    ..We show that these cluster states can directly be used to fine map QTL. The method is computationally effective at handling large data sets based on high-density SNP panels...
  36. pmc Patterns of cis regulatory variation in diverse human populations
    Barbara E Stranger
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
    PLoS Genet 8:e1002639. 2012
    ..We also identify 5,691 expression quantitative trait loci (eQTLs) after controlling for both non-genetic factors and population admixture and observe that half of ..
  37. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  38. pmc Revealing the architecture of gene regulation: the promise of eQTL studies
    Yoav Gilad
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Trends Genet 24:408-15. 2008
    Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool for identifying genetic variants that affect gene regulation...
  39. pmc A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
    Matthias Heinig
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    Nature 467:460-4. 2010
    ..15), which was one of five single nucleotide polymorphisms in this region associated with EBI2 (GPR183) expression. These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D...
  40. pmc SCAN: SNP and copy number annotation
    Eric R Gamazon
    Department of Medicine, The University of Chicago, Chicago, IL, USA
    Bioinformatics 26:259-62. 2010
    ..by combining several approaches, involving not only publicly available physical and functional annotations but also multilocus linkage disequilibrium (LD) annotations as well as annotations of expression quantitative trait loci (eQTLs).
  41. pmc Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies
    Tsun Po Yang
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK
    Bioinformatics 26:2474-6. 2010
    ..Genevar allows researchers to investigate expression quantitative trait loci (eQTL) associations within a gene locus of interest in real time...
  42. pmc Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
    Benjamin P Fairfax
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 44:502-10. 2012
    ..primary monocytes and B cells, we identify new predominantly cell type-specific cis and trans expression quantitative trait loci (eQTLs), including multi-locus trans associations to LYZ and KLF4 in monocytes and B cells, respectively...
  43. pmc Genomewide rapid association using mixed model and regression: a fast and simple method for genomewide pedigree-based quantitative trait loci association analysis
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Genetics 177:577-85. 2007
    For pedigree-based quantitative trait loci (QTL) association analysis, a range of methods utilizing within-family variation such as transmission-disequilibrium test (TDT)-based methods have been developed...
  44. pmc Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
    Alexandra C Nica
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 6:e1000895. 2010
    ..Expression quantitative trait loci (eQTLs) have been implicated in disease associations through overlaps between eQTLs and GWAS signals...
  45. pmc Data and theory point to mainly additive genetic variance for complex traits
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 4:e1000008. 2008
    ..We conclude that interactions at the level of genes are not likely to generate much interaction at the level of variance...
  46. doi Mapping genes for complex traits in domestic animals and their use in breeding programmes
    Michael E Goddard
    Department of Agriculture and Food Systems, University of Melbourne, Royal Parade, Parkville 3010, Australia
    Nat Rev Genet 10:381-91. 2009
    ..This approach is expected to double the rate of genetic improvement per year in many livestock systems...
  47. pmc Gene-environment interaction in yeast gene expression
    Erin N Smith
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 6:e83. 2008
    ..These observations will guide the design of studies aimed at understanding the genetic basis of complex traits...
  48. doi Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
    Weiya Xue
    National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Nat Genet 40:761-7. 2008
    ..Natural mutants with reduced function enable rice to be cultivated in temperate and cooler regions. Thus, Ghd7 has played crucial roles for increasing productivity and adaptability of rice globally...
  49. pmc Gramene database in 2010: updates and extensions
    Ken Youens-Clark
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Nucleic Acids Res 39:D1085-94. 2011
    ..last decade to become a robust resource for plant genomics hosting a wide array of data sets including quantitative trait loci (QTL), metabolic pathways, genetic diversity, genes, proteins, germplasm, literature, ontologies and a ..
  50. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  51. doi Drought stress and tropical maize: QTL-by-environment interactions and stability of QTLs across environments for yield components and secondary traits
    Rainer Messmer
    ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
    Theor Appl Genet 119:913-30. 2009
    ..Those regions are clear targets for future marker-assisted breeding, and our results confirm that the best approach to breeding for drought tolerance includes selection under water stress...
  52. pmc Predicting quantitative traits with regression models for dense molecular markers and pedigree
    Gustavo de Los Campos
    Department of Animal Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 182:375-85. 2009
    ..Results indicate that inclusion of markers in the regression further improved the predictive ability of models. An R program that implements the proposed model is freely available...
  53. pmc Linkage and association mapping of Arabidopsis thaliana flowering time in nature
    Benjamin Brachi
    Laboratoire Génétique et Evolution des Populations Végétales, Unité Mixte de Recherche CNRS 8016, Université des Sciences et Technologies de Lille 1, Villeneuve d Ascq, France
    PLoS Genet 6:e1000940. 2010
    ..Instead, we found a prevalence of genes involved in the regulation of the plant circadian clock. Furthermore, we identified new genomic regions lacking obvious candidate genes...
  54. pmc A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
    Oliver Stegle
    Max Planck Institutes Tübingen, Tubingen, Germany
    PLoS Comput Biol 6:e1000770. 2010
    ..Here, we present VBQTL, a probabilistic approach for mapping expression quantitative trait loci (eQTLs) that jointly models contributions from genotype as well as known and hidden confounding factors...
  55. doi Rare genetic variation at Zea mays crtRB1 increases beta-carotene in maize grain
    Jianbing Yan
    International Maize and Wheat Improvement Center, Texcoco, Mexico
    Nat Genet 42:322-7. 2010
    ....
  56. pmc Association mapping of kernel size and milling quality in wheat (Triticum aestivum L.) cultivars
    Flavio Breseghello
    Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 172:1165-77. 2006
    ..Our results demonstrated that association mapping could complement and enhance previous QTL information for marker-assisted selection...
  57. pmc Revealing the genetic structure of a trait by sequencing a population under selection
    Leopold Parts
    The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Genome Res 21:1131-8. 2011
    ....
  58. pmc Genetic control of human brain transcript expression in Alzheimer disease
    Jennifer A Webster
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Am J Hum Genet 84:445-58. 2009
    ..We suggest that studying the transcriptome as a quantitative endo-phenotype has greater power for discovering risk SNPs influencing expression than the use of discrete diagnostic categories such as presence or absence of disease...
  59. doi Array-based high-throughput DNA markers for crop improvement
    P K Gupta
    Molecular Biology Laboratory, Department of Genetics and Plant Breeding, Ch Charan Singh University, Meerut, Uttar Pradesh, India
    Heredity (Edinb) 101:5-18. 2008
    ..the markers of choice for the future and are already being used for construction of high-density maps, quantitative trait loci (QTL) mapping (including expression QTLs) and genetic diversity analysis with a limited expense in terms ..
  60. pmc Trait variation in yeast is defined by population history
    Jonas Warringer
    Department of Cell and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
    PLoS Genet 7:e1002111. 2011
    ..Overall, this study represents a step towards an in-depth understanding of the causal relationship between co-variation in ecology, selection pressure, natural traits, molecular mechanism, and alleles in a key model organism...
  61. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  62. pmc SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
    Kristian Holm
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Norway
    BMC Bioinformatics 11:600. 2010
    ....
  63. pmc Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue
    Federico Innocenti
    Cancer Research Center, Committee on Clinical Pharmacology and Pharmacogenomics, Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1002078. 2011
    The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits...
  64. pmc R/qtl: high-throughput multiple QTL mapping
    Danny Arends
    Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands
    Bioinformatics 26:2990-2. 2010
    R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types...
  65. pmc Learning a prior on regulatory potential from eQTL data
    Su In Lee
    Computer Science Department, Stanford University, Stanford, California, United States of America
    PLoS Genet 5:e1000358. 2009
    ....
  66. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. The Alzheimer's Disease Neuroimaging Initiative 1...
  67. ncbi Hd3a, a rice ortholog of the Arabidopsis FT gene, promotes transition to flowering downstream of Hd1 under short-day conditions
    Shoko Kojima
    Institute of the Society for Techno Innovation of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki, 305 0854 Japan
    Plant Cell Physiol 43:1096-105. 2002
    ....
  68. pmc Genetic architecture of quantitative traits in mice, flies, and humans
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Genome Res 19:723-33. 2009
    ..Despite substantial advances in mapping quantitative trait loci, the identification of the quantitative trait genes and ultimately the sequence variants has proved more ..
  69. pmc High-throughput genotyping by whole-genome resequencing
    Xuehui Huang
    National Center for Gene Research and Institute of Plant Physiology and Ecology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China
    Genome Res 19:1068-76. 2009
    ....
  70. pmc Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines
    Edwin Choy
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
    PLoS Genet 4:e1000287. 2008
    ..While LCLs are a promising model for pharmacogenetic experiments, biological noise and in vitro artifacts may reduce power and have the potential to create spurious association due to confounding...
  71. pmc Construction of a 10,000-marker ultradense genetic recombination map of potato: providing a framework for accelerated gene isolation and a genomewide physical map
    Hans van Os
    Laboratory of Plant Breeding, Wageningen University, The Netherlands
    Genetics 173:1075-87. 2006
    ..potatogenome.net)...
  72. pmc An integrative genomics approach to infer causal associations between gene expression and disease
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington 98109, USA
    Nat Genet 37:710-7. 2005
    ..We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity...
  73. pmc Genomewide SNP variation reveals relationships among landraces and modern varieties of rice
    Kenneth L McNally
    International Rice Research Institute, DAPO Box 7777, Metro Manila 1301, The Philippines
    Proc Natl Acad Sci U S A 106:12273-8. 2009
    ..These comprehensive SNP data provide a foundation for deep exploration of rice diversity and gene-trait relationships and their use for future rice improvement...
  74. pmc Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..These changes could have a significant impact on the risk of obesity-related morbidity in the general population...
  75. pmc The impact of genetic architecture on genome-wide evaluation methods
    Hans D Daetwyler
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Roslin EH25 9PS, United Kingdom
    Genetics 185:1021-31. 2010
    ..using stochastic simulation across three effective population sizes and a wide range of numbers of quantitative trait loci (N(QTL)). GBLUP had a constant accuracy, for a given heritability and sample size, regardless of N(QTL)...
  76. pmc Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana
    Yan Li
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:21199-204. 2010
    ..Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously ..
  77. doi Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    Mark I McCarthy
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Rev Genet 9:356-69. 2008
    ....
  78. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  79. pmc A genome-wide association study identifies protein quantitative trait loci (pQTLs)
    David Melzer
    Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
    PLoS Genet 4:e1000072. 2008
    ..These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways.
  80. pmc PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
    Lei Bao
    Department of Molecular Sciences, Memphis, TN 38163, USA
    Nucleic Acids Res 35:D51-4. 2007
    ..It is a resource for studying PolymiRTSs and their implications in phenotypic variations. PolymiRTS database can be accessed at http://compbio.utmem.edu/miRSNP/...
  81. pmc Ehd1, a B-type response regulator in rice, confers short-day promotion of flowering and controls FT-like gene expression independently of Hd1
    Kazuyuki Doi
    Plant Breeding Laboratory, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Genes Dev 18:926-36. 2004
    ..Microarray analysis further revealed a few MADS box genes downstream of Ehd1. Our results indicate that a novel two-component signaling cascade is integrated into the conserved pathway in the photoperiodic control of flowering in rice...
  82. pmc Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
    Amy Murphy
    Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 19:4745-57. 2010
    ..Population-based integrative genetic approaches can help identify such variation and enhance our understanding of the genetic basis of complex traits...
  83. ncbi Genetic basis of individual differences in the response to small-molecule drugs in yeast
    Ethan O Perlstein
    Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:496-502. 2007
    ..Our results provide a step toward a systematic understanding of small-molecule drug action in genetically distinct individuals...
  84. pmc Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast
    Himanshu Sinha
    European Molecular Biology Laboratory, Heidelberg, Germany
    Genetics 180:1661-70. 2008
    Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and ..
  85. doi Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice
    Yongqing Jiao
    State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Nat Genet 42:541-4. 2010
    ..Our study suggests that OsSPL14 may help improve rice grain yield by facilitating the breeding of new elite rice varieties...
  86. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  87. pmc Development of a near-isogenic line population of Arabidopsis thaliana and comparison of mapping power with a recombinant inbred line population
    Joost J B Keurentjes
    Laboratory of Genetics, Wageningen University, NL 6703 BD, Wageningen, The Netherlands
    Genetics 175:891-905. 2007
    ..These analyses are expected to facilitate experimental design for QTL mapping using these two common types of segregating populations...
  88. doi Identification and characterization of large-effect quantitative trait loci for grain yield under lowland drought stress in rice using bulk-segregant analysis
    Ramaiah Venuprasad
    Plant Breeding Genetics and Biotechnology Division, International Rice Research Institute, DAPO Box 7777, Manila, Philippines
    Theor Appl Genet 120:177-90. 2009
    ..F(4:5) population of 490 recombinant inbred lines (RILs) from the cross Apo/(2*)Swarna was used to detect quantitative trait loci (QTL) with large effects on grain yield under drought stress using bulk-segregant analysis (BSA)...
  89. pmc Expression quantitative trait loci: replication, tissue- and sex-specificity in mice
    Atila Van Nas
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 185:1059-68. 2010
    ..Local expression quantitative trait loci (eQTL) generally act in cis (that is, control the expression of only the contiguous structural gene), ..
  90. pmc Variants in MTNR1B influence fasting glucose levels
    Inga Prokopenko
    1 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK 2 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK 3 These authors contributed equally to this work
    Nat Genet 41:77-81. 2009
    ..Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci...
  91. pmc Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation
    Tomas Babak
    Rosetta Inpharmatics, LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    BMC Genomics 11:473. 2010
    ....
  92. pmc A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana
    Paula X Kover
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Genet 5:e1000551. 2009
    ..Analytical methods were developed to fine-map quantitative trait loci (QTL) in the MAGIC lines by reconstructing the genome of each line as a mosaic of the founders...
  93. pmc Expression quantitative trait loci detected in cell lines are often present in primary tissues
    Kevin Bullaughey
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 18:4296-303. 2009
    Expression quantitative trait loci (eQTL) mapping is a powerful tool for identifying genetic regulatory variation...
  94. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008
    ..This region is highly enriched in quantitative trait loci (QTLs) that control neural and behavioral phenotypes, including motor behavior, escape latency, ..
  95. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
  96. ncbi Genomic selection
    M E Goddard
    University of Melbourne, Attwood, Australia
    J Anim Breed Genet 124:323-30. 2007
    ..form of marker-assisted selection in which genetic markers covering the whole genome are used so that all quantitative trait loci (QTL) are in linkage disequilibrium with at least one marker...
  97. pmc A first generation BAC-based physical map of the rainbow trout genome
    Yniv Palti
    National Center for Cool and Cold Water Aquaculture, ARS USDA, Kearneysville, WV 25430, USA
    BMC Genomics 10:462. 2009
    ..Many quantitative trait loci (QTL) have been identified for production and life-history traits in rainbow trout...
  98. pmc New susceptibility locus for coronary artery disease on chromosome 3q22.3
    Jeanette Erdmann
    Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
    Nat Genet 41:280-2. 2009
    ..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11)...
  99. pmc Hierarchical generalized linear models for multiple quantitative trait locus mapping
    Nengjun Yi
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 181:1101-13. 2009
    ..generalized linear models and computationally efficient algorithms for genomewide analysis of quantitative trait loci (QTL) for various types of phenotypes in experimental crosses...
  100. doi Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    David Alexandre Tregouet
    Institut National de la Santé Et de la Recherche Médicale INSERM Unité Mixte de Recherche UMR_S 525, Université Pierre et Marie Curie UPMC Paris 06, Paris 75013, France
    Nat Genet 41:283-5. 2009
    ..This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits...
  101. pmc A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer
    Chun Ming Wang
    Molecular Population Genetics Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    BMC Genomics 12:174. 2011
    High density linkage maps are essential for comparative analysis of synteny, fine mapping of quantitative trait loci (QTL), searching for candidate genes and facilitating genome sequence assembly...

Research Grants103 found, 100 shown here

  1. A GENETIC ANALYSIS OF TASTE IN DROSOPHILA
    Beth Gordesky Gold; Fiscal Year: 2007
    ..Our present goals are to elucidate the range of taste responses of Drosophila, to find quantitative trait loci (QTL) that influence taste behavior, and to sequence the Gr5a cluster of related taste receptor genes to ..
  2. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2010
    ..A total of 29 genomic loci (Pgia1-Pgia29 ) controlling PGIA were identified. Many of these quantitative trait loci (QTLs) correlated with those identified in collagen-induced arthritis (CIA) in mice (mCia) and rats, ..
  3. Genetic Analysis of Murine Chronic Hypoxia-Induced Pulmonary Hypertension
    William C Nichols; Fiscal Year: 2010
    ..analysis of chronic hypoxia-induced pulmonary hypertension;2) Perform conventional mapping to identify quantitative trait loci (QTLs) contributing to chronic hypoxia-induced PH...
  4. Genetic Architecture of the Mammalian (Canid) Skeleton
    KARL LARK; Fiscal Year: 2007
    ..From this information it has been possible to identify QTLs (haplotypes of Quantitative Trait Loci) that inform the skeleton...
  5. REGULATION OF APOB SECRETION IN INBRED MOUSE STRAINS
    Li Shin Huang; Fiscal Year: 2009
    ..Further genetic studies of two mouse strains identified two novel quantitative trait loci (QTL) on chromosomes 6 and 4 which have major effects on plasma apo B levels...
  6. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    JANIS WEIS; Fiscal Year: 2009
    ..B. burgdorferi arthritis associated (Bbaa) Quantitative Trait Loci (QTL) on five chromosomes were previously identified, and reciprocal interval specific congenic lines (..
  7. Genetic Predisposition for Intimal Hyperplasia in Mice
    Renee C LeBoeuf; Fiscal Year: 2010
    ..doubled an F2 population between FVB (susceptible) and C57BL/6 (resistant) strains and identified 6 quantitative trait loci (QTL)...
  8. Genetic Vulnerability of Drugs of Abuse
    Kari Buck; Fiscal Year: 2007
    b>Quantitative trait loci (QTL) are chromosomal regions containing genes that influence a complex trait such as drug withdrawal severity...
  9. Genetic controls of mineral consumption
    Michael G Tordoff; Fiscal Year: 2010
    ..We have already identified several quantitative trait loci (QTLs) related to consumption of these minerals...
  10. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ..Strains will be selected for quantitative trait loci (QTL) analyses based on their strain-specific response such that pairs of strains exhibiting the largest ..
  11. MECHANISMS OF RESISTANCE TO EXCITOTOXIC CELL DEATH
    PAULA SCHAUWECKER; Fiscal Year: 2007
    ..During the last four years of present RO1 funding, we have identified the location of three significant quantitative trait loci (QTL) on chromosomes 18, 15, and 4 in the mouse genome, responsible for seizure-induced cell death ..
  12. Phenotypic Determinants of Murine Cholelithiasis
    Martin Carey; Fiscal Year: 2004
    ..critical pathophysiological changes that are induced by genetic susceptibility within newly-identified quantitative trait loci (QTL) in genetically-diverse inbred mouse strains...
  13. BLOOD PRESSURE CANDIDATE GENE SCREENING--A NEW PARADIGM
    GEORGE CICILA; Fiscal Year: 2001
    ..The applicants have linked loci on rat chromosomes 3 and 7 to blood pressure quantitative trait loci (BP QTL) in a segregating population bred from inbred Dahl salt-sensitive (S) and salt-resistant (R) rats ..
  14. Genetic Variation in Factor IX and Thrombosis Risk
    Laura Almasy; Fiscal Year: 2006
    ..f-IX levels are strongly correlated genetically (rho[sub g] about 60%), indicating a number of the f-IX quantitative trait loci (QTLs) also influence thrombosis risk...
  15. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..We have successfully mapped quantitative trait loci (QTLs) for femoral neck and femoral midshaft phenotypes, the primary and secondary goals of the project...
  16. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2009
    ..We have successfully mapped quantitative trait loci (QTLs) for femoral neck and femoral midshaft phenotypes, the primary and secondary goals of the project...
  17. Joint Determinants of Bone Density and CVD Calcification
    Braxton Mitchell; Fiscal Year: 2004
    ..repeat (STR) markers spaced at approximately 10 cM intervals and perform a genome-wide scan to detect quantitative trait loci (QTLs) associated with variation in BMD and related traits...
  18. GENETIC REGULATION OF IGF-I IN PEAK BONE DENSITY OF MICE
    Clifford Rosen; Fiscal Year: 2004
    ..established: 1) serum IGF-I is a heritable polygenic train; 2) three major non-growth hormone dependent quantitative trait loci (QTLs) and one interactive QTL influence the serum IGF-I phenotype; 3) two IGF-I QTLs associate with ..
  19. Genetic Basis of Lung Tumor Progression in Mice
    Ming You; Fiscal Year: 2006
    ..A quantitative trait loci (QTL) responsible for lung tumor progression has been mapped to chromosome 4...
  20. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    ABRAHAM PALMER; Fiscal Year: 2009
    ..We will use mice to better define chromosomal regions (also called quantitative trait loci or QTL) that contain genes that influence sensitivity to the acute locomotor stimulant effects of ..
  21. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    Abraham A Palmer; Fiscal Year: 2010
    ..We will use mice to better define chromosomal regions (also called quantitative trait loci or QTL) that contain genes that influence sensitivity to the acute locomotor stimulant effects of ..
  22. Mouse QTL and Human Association Study of Methamphetamine Sensitivity
    Abraham A Palmer; Fiscal Year: 2010
    ..We will use mice to better define chromosomal regions (also called quantitative trait loci or QTL) that contain genes that influence sensitivity to the acute locomotor stimulant effects of ..
  23. Drosophila as a model for chemotherapy pharmacogenomics
    ANTHONY DOUGLAS LONG; Fiscal Year: 2010
    ..Unfortunately, progress at identifying the genetic loci (Quantitative Trait Loci or QTL) contributing to complex disease has been slow...
  24. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    Kari Buck; Fiscal Year: 2003
    b>Quantitative trait loci (QTLs) are chromosomal regions containing genes that influence a complex trait such as drug withdrawal severity...
  25. GENETIC VULNERABILITY TO DRUGS OF ABUSE
    John Crabbe; Fiscal Year: 2002
    b>Quantitative trait loci (QTLs) are chromosomal regions containing genes that influence a complex trait such as drug withdrawal severity...
  26. Gene Mapping of Alcohol-Related Traits in Rat Lines
    Lucinda Carr; Fiscal Year: 2003
    ..is to identify the genes that influence alcohol preference located within the chromosomal regions (quantitative trait loci) that were identified in the previous proposal...
  27. Congenic Mouse Strains Harboring Bone Strength Quantitative Trait Loci
    Robert D Blank; Fiscal Year: 2010
    ..We have mapped biomechanical performance quantitative trait loci (QTLs) in intercrosses of HcB- 13 x HcB-14 and HcB-8 x HcB 23 recombinant congenic mice, with QTLs ..
  28. Congenic Mouse Strains Harboring Bone Strength Quantitative Trait Loci
    Robert Blank; Fiscal Year: 2009
    ..We have mapped biomechanical performance quantitative trait loci (QTLs) in intercrosses of HcB- 13 x HcB-14 and HcB-8 x HcB 23 recombinant congenic mice, with QTLs ..
  29. Identifying Chromosome 3 Blood Pressure QTL Candidates
    GEORGE CICILA; Fiscal Year: 2006
    ..One of these blood pressure (BP) quantitative trait loci (QTL), located near the q-terminus of RNO3, was confirmed by developing a congenic strain, S.R-Edn3...
  30. Genetics of Alopecia Areata in the C3H/HeJ Mouse
    JOHN PAUL SUNDBERG; Fiscal Year: 2010
    ..disease), when combined with quantitative real time RT PCR (QPCR) for all genes within each of the 4 AA quantitative trait loci (QTLs) and haplotype mapping data based on total genomic sequencing (Sanger draft sequences), will be ..
  31. The Genetic Basis of Anthropophily in Anopheles gambiae
    Michel A Slotman; Fiscal Year: 2010
    ..We will backcross these two species in a Quantitative Trait Loci mapping experiment to identify regions of the genome that are responsible for the attraction of An...
  32. Identifying Chromosome 3 Blood Pressure QTL Candidates
    GEORGE CICILA; Fiscal Year: 2003
    ..One of these blood pressure (BP) quantitative trait loci (QTL), located near the q-terminus of RNO3, was confirmed by developing a congenic strain, S.R-Edn3...
  33. Structural analysis of alcohol-dependent activation of GIRKs
    PAUL A contact SLESINGER; Fiscal Year: 2010
    ..Moreover, a quantitative trait loci with a large effect on predisposition to sedative withdrawal, such as from ethanol, was narrowed to a ..
  34. Molecular and Genetic Analysis of Murine Steatohepatitis
    Richard Green; Fiscal Year: 2009
    ..NASH is a polygenic disease, and Quantitative Trait Loci (QTL) analysis is a widely utilized genetic technique that can be applied to murine models in order to ..
  35. Molecular and Genetic Analysis of Murine Steatohepatitis
    Richard M Green; Fiscal Year: 2010
    ..NASH is a polygenic disease, and Quantitative Trait Loci (QTL) analysis is a widely utilized genetic technique that can be applied to murine models in order to ..