myc genes

Summary

Summary: Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8.

Top Publications

  1. ncbi Contributions of Myc to tumorigenesis
    Werner Lutz
    Institute for Molecular Biology and Tumor Research, University of Marburg, IMT, Mannkopff Str 2, 35033, Marburg, Germany
    Biochim Biophys Acta 1602:61-71. 2002
  2. pmc Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    Adam Siddiqui-Jain
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 99:11593-8. 2002
  3. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
  4. ncbi MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, California 94305, USA
    Nature 431:1112-7. 2004
  5. ncbi Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
    E M Blackwood
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 251:1211-7. 1991
  6. ncbi Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    Meenakshi Jain
    Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5151, USA
    Science 297:102-4. 2002
  7. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
  8. pmc Targeted expression of MYCN causes neuroblastoma in transgenic mice
    W A Weiss
    G W Hooper Foundation, and Department of Neurology, University of California, San Francisco 94143 0552, USA
    EMBO J 16:2985-95. 1997
  9. pmc N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
    B A Malynn
    The Center for Blood Research, Boston, Massachusetts 02115 USA
    Genes Dev 14:1390-9. 2000
  10. ncbi Reversible tumorigenesis by MYC in hematopoietic lineages
    D W Felsher
    Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
    Mol Cell 4:199-207. 1999

Detail Information

Publications325 found, 100 shown here

  1. ncbi Contributions of Myc to tumorigenesis
    Werner Lutz
    Institute for Molecular Biology and Tumor Research, University of Marburg, IMT, Mannkopff Str 2, 35033, Marburg, Germany
    Biochim Biophys Acta 1602:61-71. 2002
    ..68 (1996) 109-182]. In this article, we will argue that current progress allows us to present testable hypotheses on how Myc affects specific properties of transformed cells...
  2. pmc Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    Adam Siddiqui-Jain
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 99:11593-8. 2002
    ..Furthermore, we establish the principle that c-MYC transcription can be controlled by ligand-mediated G-quadruplex stabilization...
  3. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
    ..Future therapies will focus increasingly on the genes and biological pathways that contribute to malignant transformation or progression...
  4. ncbi MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
    Catherine M Shachaf
    Division of Medical Oncology, Department of Medicine, Stanford University, California 94305, USA
    Nature 431:1112-7. 2004
    ....
  5. ncbi Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
    E M Blackwood
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 251:1211-7. 1991
    ..These results suggest that Myc family proteins undergo a restricted set of interactions in the cell and may belong to the more general class of eukaryotic DNA-binding transcription factors...
  6. ncbi Sustained loss of a neoplastic phenotype by brief inactivation of MYC
    Meenakshi Jain
    Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5151, USA
    Science 297:102-4. 2002
    ..These results raise the possibility that transient inactivation of MYC may be an effective therapy for certain cancers...
  7. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
    ..Suprisingly, the tumours derive from a cell with the hallmarks of a primitive haemopoietic cell, perhaps a lymphoid-committed stem cell...
  8. pmc Targeted expression of MYCN causes neuroblastoma in transgenic mice
    W A Weiss
    G W Hooper Foundation, and Department of Neurology, University of California, San Francisco 94143 0552, USA
    EMBO J 16:2985-95. 1997
    ....
  9. pmc N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation
    B A Malynn
    The Center for Blood Research, Boston, Massachusetts 02115 USA
    Genes Dev 14:1390-9. 2000
    ..Therefore, the myc gene family must have evolved, to a large extent, to facilitate differential patterns of expression...
  10. ncbi Reversible tumorigenesis by MYC in hematopoietic lineages
    D W Felsher
    Department of Medicine, G W Hooper Foundation, San Francisco, California, USA
    Mol Cell 4:199-207. 1999
    ..We conclude that even though tumorigenesis is a multistep process, remediation of a single genetic lesion may be sufficient to reverse malignancy...
  11. ncbi The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4
    Jeyaprakashnarayanan Seenisamy
    College of Pharmacy, The University of Arizona, 1703 East Mabel, Tucson, Arizona 85721, USA
    J Am Chem Soc 126:8702-9. 2004
    ....
  12. ncbi Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations
    Asa Karlsson
    Division of Oncology, Department of Medicine, Stanford University, CA 94305, USA
    Blood 101:2797-803. 2003
    ..We conclude that even highly genetically complex cancers are reversible on the inactivation of MYC, unless they acquire novel genetic alterations that can sustain a neoplastic phenotype...
  13. ncbi Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line
    Isabel Schlosser
    GSF Research Centre, Institute of Clinical Molecular Biology and Tumour Genetics, Marchioninistr 25, D 81377 Munich, Germany
    Oncogene 24:520-4. 2005
    ..The data support our current notion that Myc is essential for the regulation of a large number of growth-related genes in B cells, and cannot be replaced by other serum-induced factors...
  14. ncbi The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements
    T Albert
    Institute of Clinical Molecular Biology and Tumor Genetics, Department for Protein Chemistry, Research Centre for Environment and Health (GSF, Marchioninistrasse 25, , Germany
    J Biol Chem 276:20482-90. 2001
    ....
  15. ncbi A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
    Elizabeth Yeh
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Cell Biol 6:308-18. 2004
    ..Thus, Ras-dependent signalling cascades ensure transient and self-limiting accumulation of c-Myc, disruption of which contributes to human cell oncogenesis...
  16. pmc Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    C M Eischen
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 13:2658-69. 1999
    ..Therefore, Myc activation strongly selects for spontaneous inactivation of the ARF-Mdm2-p53 pathway in vivo, cancelling its protective checkpoint function and accelerating progression to malignancy...
  17. ncbi CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease
    R Ohlsson
    Dept of Genetics and Development, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Trends Genet 17:520-7. 2001
    ..CTCF emerges, therefore, as a central player in networks linking expression domains with epigenetics and cell growth regulation...
  18. ncbi c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
    Satoshi Kanazawa
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Oncogene 22:5707-11. 2003
    ..Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc...
  19. ncbi Molecular determinants for the tissue specificity of SERMs
    Yongfeng Shang
    Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 295:2465-8. 2002
    ..Thus cell type- and promoter-specific differences in coregulator recruitment determine the cellular response to SERMs...
  20. ncbi Translocations involving c-myc and c-myc function
    L M Boxer
    Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California CA 94305, USA
    Oncogene 20:5595-610. 2001
    ..Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation...
  21. ncbi Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
    G C Prendergast
    Howard Hughes Medical Institute, Kaplan Cancer Center, New York, New York
    Cell 65:395-407. 1991
    ..Coexpression of Myn in a myc/ras rat embryo fibroblast focus formation assay specifically augmented c-myc transforming activity. We suggest that interaction of Myn with c-Myc stabilizes sequence-specific DNA binding in vivo...
  22. pmc AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations
    Davide F Robbiani
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Cell 135:1028-38. 2008
    ..Thus, in addition to producing somatic mutations and DNA breaks in antibody genes, AID is also responsible for the DNA lesions in oncogenes that are required for their translocation...
  23. ncbi Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma
    Tom Van Maerken
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Cancer Res 66:9646-55. 2006
    ..The observed treatment effects without the need of imposing a genotoxic burden suggest that selective MDM2 antagonists might be beneficial for treatment of neuroblastoma patients with and without MYCN amplification...
  24. pmc Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    J J Jacobs
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Genes Dev 13:2678-90. 1999
    ..Together, these results reinforce the critical role of Bmi-1 as a dose-dependent regulator of ink4a-ARF, which on its turn acts to prevent tumorigenesis on activation of oncogenes such as c-myc...
  25. pmc Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer
    N N Nupponen
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Finland
    Am J Pathol 154:1777-83. 1999
    ..These results imply that genomic aberrations of translation initiation factors, such as eIF3-p40, may contribute to the pathogenesis of breast and prostate cancer...
  26. ncbi Radiation therapy depletes extrachromosomally amplified drug resistance genes and oncogenes from tumor cells via micronuclear capture of episomes and double minute chromosomes
    Patricia V Schoenlein
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA
    Int J Radiat Oncol Biol Phys 55:1051-65. 2003
    ..To determine if clinically relevant doses of ionizing radiation are capable of inducing extrachromosomal DNA loss in transformed human cell lines...
  27. ncbi Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
    ..Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions...
  28. ncbi Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    K Bhatia
    Pediatric Branch, Clinical Oncology Program, NCI NIH, Bethesda, Maryland 20892
    Nat Genet 5:56-61. 1993
    ..Many of the observed mutations are clustered in regions associated with transcriptional activation and apoptosis, and in BLs, they frequently occur at sites of phosphorylation, suggesting that the mutations have a pathogenetic role...
  29. ncbi Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity
    D E Ayer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 72:211-22. 1993
    ..In vivo transactivation assays suggest that Myc-Max and Mad-Max complexes have opposing functions in transcription and that Max plays a central role in this network of transcription factors...
  30. ncbi Myc-driven murine prostate cancer shares molecular features with human prostate tumors
    Katharine Ellwood-Yen
    Department of Medicine, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Cell 4:223-38. 2003
    ..This approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases...
  31. ncbi c-myc expression: keep the noise down!
    Hye Jung Chung
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Mol Cells 20:157-66. 2005
    ....
  32. pmc MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination
    S A Bossone
    Department of Pathology, State University of New York, Stony Brook 11794
    Proc Natl Acad Sci U S A 89:7452-6. 1992
    ..MAZ may encode a transcription factor with dual roles in transcription initiation and termination...
  33. ncbi Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice
    Sung Sup Park
    Laboratory of Genetics, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:1306-15. 2005
    ....
  34. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    ..We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size...
  35. pmc N-myc coordinates retinal growth with eye size during mouse development
    Rodrigo A P Martins
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Genes Dev 22:179-93. 2008
    ..We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and thus coordinates the growth of both the retina and eye through extrinsic cues...
  36. ncbi Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes
    S Sawai
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    New Biol 3:861-9. 1991
    ..N-myc-null ES cells offer a valuable tool in chimera analysis to elucidate the requirement for N-myc function in embryogenesis...
  37. ncbi Molecular diagnosis of Burkitt's lymphoma
    Sandeep S Dave
    National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 354:2431-42. 2006
    ..We examined whether gene-expression profiling could reliably distinguish Burkitt's lymphoma from diffuse large-B-cell lymphoma...
  38. pmc IL-6 transgenic mouse model for extraosseous plasmacytoma
    Alexander L Kovalchuk
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1509-14. 2002
    ..These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas...
  39. ncbi Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
    Michael T Hemann
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 436:807-11. 2005
    ....
  40. ncbi The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
    Davide Ruggero
    Cancer Biology and Genetics Program, and Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Med 10:484-6. 2004
    ..Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt...
  41. ncbi Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
    L Pasqualucci
    Institute for Cancer Genetics and the Department of Pathology, Columbia University, New York, New York 10032, USA
    Nature 412:341-6. 2001
    ..By mutating multiple genes, and possibly by favouring chromosomal translocations, aberrant hypermutation may represent the major contributor to lymphomagenesis...
  42. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
  43. ncbi Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer
    M Zajac-Kaye
    Center for Cancer Research, National Cancer Institute, National Institute of Health, Navy Oncology Branch, Naval Hospital, Building 8, R 5101, Bethesda, MD 20889, USA
    Lung Cancer 34:S43-6. 2001
    ..It is proposed that both the overexpression of Myc and the deregulation of the pRB/E2F pathway promotes the G1 to S transition in parallel by activating cyclinE/cdk2 complexes in lung cancer cells...
  44. pmc c-Myc functionally cooperates with Bax to induce apoptosis
    Philippe Juin
    University of California at San Francisco Cancer Center, San Francisco, California 94143 0128, USA
    Mol Cell Biol 22:6158-69. 2002
    ..We conclude that c-Myc triggers a proapoptotic mitochondrial destabilizing activity that cooperates with proapoptotic members of the Bcl-2 family...
  45. ncbi Direct activation of TERT transcription by c-MYC
    K J Wu
    Department of Pathology, Columbia University, New York, New York 10027, USA
    Nat Genet 21:220-4. 1999
    ..Our results indicate that TERT is a target of c-MYC activity and identify a pathway linking cell proliferation and chromosome integrity in normal and neoplastic cells...
  46. ncbi Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites
    A S Zervos
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114
    Cell 72:223-32. 1993
    ....
  47. ncbi Distinct nuclear arrangement of active and inactive c-myc genes in control and differentiated colon carcinoma cells
    Andrea Harnicarová
    Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    Exp Cell Res 312:4019-35. 2006
    ..This observation enabled detection of both activity and nuclear localization of c-myc genes in single cells and in individual chromosome territories...
  48. ncbi Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene
    J Charron
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Genes Dev 6:2248-57. 1992
    ..These results demonstrate that N-myc plays an essential role during development and clearly confirm that N-myc has a physiological function that is distinct from that of the other myc-family genes...
  49. ncbi A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung
    C B Moens
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 6:691-704. 1992
    ....
  50. pmc N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor
    Rebecca Cotterman
    Department of Cell Biology, University of California Davis School of Medicine, Davis, California 95616, USA
    Cancer Res 68:9654-62. 2008
    ..These findings support a new dual model for Myc chromatin function with important implications for the role of Myc in cancer and stem cell biology, including that of induced pluripotent stem cells...
  51. ncbi Reanalysis of neuroblastoma expression profiling data using improved methodology and extended follow-up increases validity of outcome prediction
    Alexander Schramm
    Department of Pediatric Oncology and Haematology, University Children s Hospital Essen, Hufelandstrasse 55, Essen, Germany
    Cancer Lett 282:55-62. 2009
    ....
  52. pmc INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    C A Schmitt
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 13:2670-7. 1999
    ..Consequently, INK4a/ARF and p53 mutations lead to aggressive tumors by disrupting overlapping tumor suppressor functions. These data have important implications for understanding the clinical behavior of human tumors...
  53. ncbi Myc pathways provoking cell suicide and cancer
    Jonas A Nilsson
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Oncogene 22:9007-21. 2003
    ..The precise mechanism(s) by which Myc targets these pathways are largely unresolved, but we propose that they involve crosstalk and feedback regulatory loops between arbiters of cell death...
  54. pmc Burkitt lymphoma in the mouse
    A L Kovalchuk
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:1183-90. 2000
    ....
  55. ncbi Control of cell proliferation by Myc family genes
    M Eilers
    Institute for Molecular Biology and Tumour Research, University of Marburg, Germany
    Mol Cells 9:1-6. 1999
    ..In vivo, these genes control both proliferation and apoptosis. This review will focus on recent progress in understanding how the encoded proteins exert their biological functions...
  56. ncbi Molecular biology of neuroblastoma
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 17:2264-79. 1999
    ..Alterations in the expression of genes that regulate apoptosis also correlate with neuroblastoma behavior and may help to explain the phenomenon of spontaneous regression observed in a well-defined subset of patients...
  57. ncbi Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma
    K Wimmer
    University of Michigan, Department of Pediatrics, Ann Arbor 48109 0510, USA
    Oncogene 18:233-8. 1999
    ..Amplification and consequent over-expression of NAG may, therefore, contribute to the phenotype of a subset of neuroblastomas...
  58. pmc Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer
    K J Savinainen
    Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN 33014 Tampere, Finland
    Br J Cancer 90:1041-6. 2004
    ..029) in prostate carcinomas compared to BPH. The data suggest that the expression of EIF3S3 is increased in prostate cancer, and that one of the mechanisms underlying the overexpression is the amplification of the gene...
  59. ncbi Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis
    John Herrick
    Unité Stabilité des Génomes, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    Cancer Res 65:1174-9. 2005
    ..cancer-derived cell lines, we have elucidated the genomic structures of amplified regions containing HPV/myc genes over several hundreds of kilobases...
  60. pmc Genes proximal and distal to MYCN are highly expressed in human neuroblastoma as visualized by comparative expressed sequence hybridization
    Cornelia Stock
    Children s Cancer Research Institute, St Anna Kinderkrebsforschung, Kinderspitalgasse 6, A 1090 Vienna, Austria
    Am J Pathol 172:203-14. 2008
    ..The prognostic significance of expression peaks at 2p23.2-23.3, independent of MYCN and ALK status, remains to be investigated...
  61. ncbi Action of Myc in vivo - proliferation and apoptosis
    S Pelengaris
    Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Curr Opin Genet Dev 10:100-5. 2000
    ..An outstanding feature of these experiments is the demonstration that the balance between oncogene-induced proliferation and apoptosis in a given tissue can be a critical determinant in the initiation and maintenance of the tumor...
  62. ncbi Dissecting p53 tumor suppressor functions in vivo
    Clemens A Schmitt
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cancer Cell 1:289-98. 2002
    ..Therefore, apoptosis is the only p53 function selected against during lymphoma development, whereas defective cell-cycle checkpoints and aneuploidy are mere byproducts of p53 loss...
  63. pmc Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
    Jodi R Alt
    Eppley Institute for Cancer Research, Department of Pathology and Microbiology, 987696 University of Nebraska Medical Center, Omaha, NE 68198, USA
    EMBO J 22:1442-50. 2003
    ..These results support the concept that Mdm2 functions are rate limiting in lymphomagenesis and that targeting Mdm2 will enhance p53-mediated apoptosis, compromising tumor development and/or maintenance...
  64. ncbi MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis
    Yang O Huh
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Haematol 142:36-44. 2008
    ..In summary, MYC rearrangement, which occurs rarely in CLL patients, is associated with increased prolymphocytes, complex cytogenetic abnormalities, and a poor prognosis...
  65. ncbi Quadruplex-duplex competition in the nuclease hypersensitive element of human c-myc promoter: C to T mutation in C-rich strand enhances duplex association
    Kangkan Halder
    Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007, India
    Biochem Biophys Res Commun 327:49-56. 2005
    ..2 and approximately 190.6 nM for M3 and P1, respectively). We envisage that the increased affinity for the duplex state due to the mutation could play a functional role in the aberrant regulation of c-myc...
  66. ncbi Relative copy number gain of MYC in diagnostic needle biopsies is an independent prognostic factor for prostate cancer patients
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Eur Urol 52:116-25. 2007
    ..Because CGH may be difficult to implement in the clinical practice, we tested the feasibility of using a three-color fluorescent assay to assess 8q status in diagnostic, paraffin-embedded biopsy samples from prostate cancer patients...
  67. ncbi Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway
    Y Minami
    Institute for Molecular and Cellular Biology Osaka University, Japan
    Immunity 2:89-100. 1995
    ..Thus, Syk PTK may be a critical integral member of the signaling molecules engaged by the IL-2R...
  68. ncbi Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice
    Y Wang
    Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
    Oncogene 7:1241-7. 1992
    ..All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations...
  69. ncbi BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations
    Santiago Silva
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Cancer Res 63:8656-63. 2003
    ..Accelerated plasmacytomagenesis in strain C.BCL2 may be useful for designing and testing BCL2 inhibition strategies in human plasma cell tumors overexpressing BCL2, such as Waldenström's macroglobulinemia and multiple myeloma...
  70. ncbi Myc: a weapon of mass destruction
    Julie Secombe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cell 117:153-6. 2004
    ..Yet another paper identifies dE2F1 as a critical component of pathways that normally restrict the ability of growth perturbing genes like dMyc to cause organ overgrowth...
  71. ncbi Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging
    M van Lohuizen
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Cell 65:737-52. 1991
    ....
  72. ncbi A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation
    J E Prescott
    Program in Human Genetics and Molecular Biology, Department of Medicine, Johns Hopkins Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 276:48276-84. 2001
    ....
  73. ncbi Effects of 9-ene-tetrahydrocannabinol on expression of beta-type transforming growth factors, insulin-like growth factor-I and c-myc genes in the mouse uterus
    S K Das
    Department of Obstetrics Gynecology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338
    J Steroid Biochem Mol Biol 45:459-65. 1993
    ..transforming growth factors (TGF-beta 1, -beta 2 and -beta 3), insulin-like growth factor-I (IGF-I) and c-myc genes in the uteri of adult ovariectomized mice were examined using Northern blot hybridization...
  74. pmc E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 17:4782-91. 1997
    ....
  75. ncbi Hoechst 33258 binds to G-quadruplex in the promoter region of human c-myc
    Souvik Maiti
    Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007, India
    Biochem Biophys Res Commun 310:505-12. 2003
    ..23+/-0.04 x 10(5)M(-1)s(-1) and 0.686+/-0.009 s(-1), respectively. As Hoechst is known to bind A-T-rich region of duplex DNA, here we propose the likelihood of Hoechst interacting with the AAGGT loop of the quadruplex...
  76. ncbi Two c-myc genes from a tetraploid fish, the common carp (Cyprinus carpio)
    H Zhang
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Japan
    Gene 153:231-6. 1995
    Two c-myc genes have been isolated from a tetraploid fish, the common carp (Cyprinus carpio). The nucleotide (nt) sequences of the two genes and their flanking regions (CAM1, 8675 bp and CAM2, 5784 bp) have been determined...
  77. ncbi Analysis of genomic targets reveals complex functions of MYC
    Jagruti H Patel
    Wistar Institute, 3601 Spruce Street, Philadelphia 19104, USA
    Nat Rev Cancer 4:562-8. 2004
  78. ncbi A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice
    A C Davis
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Genes Dev 7:671-82. 1993
    ..c-Myc protein is necessary for embryonic survival beyond 10.5 days of gestation; however, it appears to be dispensable for cell division both in ES cell lines and in the embryo before that time...
  79. ncbi Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma
    D B Zimonjic
    Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA
    Leukemia 15:1582-8. 2001
    ..Duplication of the bands 1q23-24 commonly observed in EBV-negative lines was identified only in highly tumorigenic CA46 cells suggesting that this region harbor gene(s) associated with tumor cell invasiveness...
  80. pmc Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression
    Ram Krishna Thakur
    Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Delhi, India
    Nucleic Acids Res 37:172-83. 2009
    ..Taken together, this supports transcriptional role of NM23-H2 via a G4 motif...
  81. ncbi Viral Myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1, a possible tumor suppressor gene
    A T Tikhonenko
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    J Biol Chem 271:30741-7. 1996
    ..Moreover, its silencing might pertain to the transforming activity of Myc, since in several systems thrombospondin-1 exhibits tumor suppressor properties, presumably due to its negative effect on neovascularization...
  82. ncbi Relationship between histopathological features, MYCN amplification, and prognosis: a UKCCSG study. United Kingdom Children Cancer Study Group
    R E George
    Cancer Research Unit, Medical School, University of Newcastle upon Tyne, United Kingdom
    Med Pediatr Oncol 36:169-76. 2001
    ..Most MYCN-amplified tumours have unfavourable histology and a poorer prognosis. However, in patients with stage 4 disease and those over the age of 1 year, other factors that may influence prognosis should be determined...
  83. ncbi Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop
    B R Stanton
    Molecular Embryology Section, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 6:2235-47. 1992
    b>myc genes are thought to function in the processes of cellular proliferation and differentiation...
  84. ncbi Clinical and biologic characteristics for recurring neuroblastoma at mass screening cases in Japan
    T Tajiri
    Department of Pediatric Surgery, Kyushu University, Fukuoka City, Japan
    Cancer 92:349-53. 2001
    ..However, a few cases have an unfavorable outcome. In the current study, the authors analyzed the clinical and biologic characteristics for recurring neuroblastoma in mass screening cases...
  85. ncbi Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:2793-808. 2003
    ....
  86. ncbi Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo
    Yuka Sasakawa
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6 Kashima, Yodogawa ku, Osaka, 532 8514, Japan
    Cancer Lett 195:161-8. 2003
    ..study, we examined the effects of FK228 (FR901228, depsipeptide) on tumor growth and expression of p21 and c-myc genes in vivo. FK228 induced the expression of p21 mRNA and decreased c-myc mRNA in tumor xenograft sensitive to FK228...
  87. ncbi Amplification of c-myc oncogene by chromogenic and fluorescence in situ hybridization in archival breast cancer tissue array samples
    J K Rummukainen
    Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Lab Invest 81:1545-51. 2001
    ....
  88. ncbi Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models
    M H Jamerson
    The Lombardi Cancer Center, Georgetown University Medical Center, Georgetown University, Washington DC 20007, USA
    Oncogene 19:1065-71. 2000
    ..In this review, we address two distinct c-myc-containing bitransgenic murine mammary tumor models and discuss the contribution and possible future directions for resolution of cancer-relevant molecular pathways influenced by c-Myc...
  89. pmc p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells
    D A Tweddle
    Cancer Research Unit, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Am J Pathol 158:2067-77. 2001
    ..This suggests MYCN amplification may alter downstream mediators of p53 function in neuroblastoma...
  90. pmc Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts
    D W Felsher
    Division of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA 94305 5115, USA
    Proc Natl Acad Sci U S A 97:10544-8. 2000
    ..The loss of p53 function seems to be one mechanism by which this relaxation commonly occurs. These findings dramatize how multiple genetic events can collaborate to produce neoplastic cells...
  91. ncbi Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis
    H Murakami
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892
    Cancer Res 53:1719-23. 1993
    ....
  92. pmc STAT3 is required for the gp130-mediated full activation of the c-myc gene
    N Kiuchi
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Exp Med 189:63-73. 1999
    ..This is the first identification of the linkage between a member of the STAT family and the c-myc gene activation, and also explains how the IL-6 family of cytokines is capable of inducing the expression of the c-myc gene...
  93. ncbi Site-specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c-MYC gene in the HeLa cell cycle
    Yayoi Kinoshita
    Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:35879-89. 2004
    ..Results indicate sequence-specific loading of MCM proteins onto DNA in late G(1) followed by a recruitment to multiple sites in chromatin subsequent to replication...
  94. pmc Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, 35033 Marburg, Germany
    J Cell Biol 172:139-49. 2006
    ..Our data show that regulation of cell adhesion is a major function of the Myc-Miz1 complex and suggest that it may contribute to Myc-induced exit from the epidermal stem cell compartment...
  95. pmc An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
    G N Filippova
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 16:2802-13. 1996
    ..One CTCF binding site, conserved in mouse and human c-myc genes, is found immediately downstream of the major P2 promoter at a sequence which maps precisely within the region ..
  96. ncbi Cancer. Addiction to oncogenes--the Achilles heal of cancer
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Science 297:63-4. 2002
  97. ncbi Lack of BIC and microRNA miR-155 expression in primary cases of Burkitt lymphoma
    Joost Kluiver
    Department of Pathology and Laboratory Medicine, Groningen University Medical Center, The Netherlands
    Genes Chromosomes Cancer 45:147-53. 2006
    ..Expression of BIC and miR-155 in 3 latency type III EBV-positive BL cell lines and in all primary PTLD cases suggests a possible role for EBV latency type III specific proteins in the induction of BIC expression...
  98. ncbi MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children
    G P Tonini
    Department of Hematology Oncology, Giannina Gaslini Children s Hospital, Genova, Italy
    J Clin Oncol 15:85-93. 1997
    ..To evaluate the prognostic role of MYCN oncogene amplification in children with neuroblastoma...
  99. ncbi Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    L Madisen
    Hutchinson Cancer Center, University of Washington School of Medicine, Seattle 98104
    Genes Dev 8:2212-26. 1994
    ..These results suggest that HS1234 may function as a locus control region (LCR), deregulating c-myc expression in t(15;12) plasmacytomas, as well as potentially contributing to aspects of normal IgH chain expression...
  100. ncbi Reconstructing MYC
    David L Levens
    Gene Regulation Section, Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892 1500, USA
    Genes Dev 17:1071-7. 2003
  101. ncbi Partial restoration of B cell development in Jak-3(-/-) mice achieved by co-expression of IgH and E(mu)-myc transgenes
    Stacey R Dillon
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int Immunol 14:893-904. 2002
    ..Thus, Jak-3 seems to play several important roles in B cells: during development, to enable cell division, Ig gene rearrangement and cell differentiation, and in mature cells, to promote B cell survival in the periphery...

Research Grants63

  1. C MYC--TRANSCRIPTION AND APOPTOSIS
    Chi V Dang; Fiscal Year: 2011
    ....
  2. Analysis of the Human c-myc Gene Replication Origin
    Michael Leffak; Fiscal Year: 2012
    ..Thus, our studies are likely to provide fundamental new insight into the mechanisms of DNA replication, the origins of genetic diseases, and new models for disease treatment. ..
  3. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2013
    ..We will investigate what makes these other sites targets for AID, and for DNA break formation. Thus our studies will also shed light on the important question of how AID chooses its targets. ..
  4. HOST IMMUNITY TO EBV INFECTION IN VITRO AND IN VIVO
    David A Thorley-Lawson; Fiscal Year: 2013
    ..It will also have the direct clinical implication that intervention to reduce the malarial burden and the ability of malarial antigens to trigger AID could dramatically reduce the incidence of an important childhood lymphoma - eBL. ..
  5. Metformin as a novel chemopreventive agent for prostate cancer
    Xin Li; Fiscal Year: 2013
    ..e. those with PIN or high-grade PIN). The novel combined cancer prevention therapy using metformin and mTOR inhibitors proposed in this study may display promising synergistic efficacy and will be translational to clinical application. ..
  6. A Mouse Model for the Rare Plasma Cell Disease AL Amyloidosis
    David C Seldin; Fiscal Year: 2010
    ..abstract_text> ..
  7. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..Discovery of the functional MHC genes would open the door for zebrafish researchers studying many aspects of transplantation and vertebrate biology. ..
  8. NF-kappaB N-myc in Oncogenic Pathways of the CNS
    Raquel Sitcheran; Fiscal Year: 2010
    ..These studies have the potential to offer new insight into drug design targeting oncogenic pathways regulated by NF-KB and N-myc. ..
  9. Coordinate Regulation of p53 and c-MYC in an HTLV-1 Model of Carcinogenesis
    Robert L Harrod; Fiscal Year: 2012
    ..This R15 AREA project will provide excellent cancer research training opportunities for undergraduates and graduate students to better prepare them for future careers in the basic or clinical oncological sciences. ..
  10. MicroRNAs and chromosome 22q in the colon
    Anil K Rustgi; Fiscal Year: 2012
    ..Our studies hope to reveal new paradigms in CRC pathogenesis, and offer opportunities for exploiting this knowledge in novel diagnostics and therapeutics. ..
  11. Regulation of cell growth and proliferation by Myc
    ROBERT NEIL EISENMAN; Fiscal Year: 2013
    ..Importantly, myc genes are mutated and deregulated in a very wide range of human cancers...
  12. Investigation of a novel regulator of Myc-driven tumorigenesis
    Mark W Gramling; Fiscal Year: 2012
    ..Our studies should also define the potential of MTBP and its interacting factors as therapeutic targets in Myc driven malignancies. ..
  13. Targeting the MYC Oncogene with CDK Inhibitors
    Andrei Goga; Fiscal Year: 2013
    ..The knowledge gained from these studies will facilitate the development of new therapeutics that target tumor cells with particular genetic changes by precisely inhibiting the cell division cycle. ..
  14. Interplay of Myc, Tumor Supressors and Regulators of Differentiation in Lymphoma
    John L Cleveland; Fiscal Year: 2012
    ..Since Myc oncoproteins are activated in up to 70% of all cancers, our discoveries may provide the foundation for developing new agents that are broadly effectively in cancer prevention and treatment. ..
  15. "Oncorequisite" Genes in MYC-mediated Transformation
    Hui Feng; Fiscal Year: 2010
    ..By identifying mutant genes that delay the onset of Myc-driven T-cell leukemia in fish, this project seeks to discover molecules that could serve as useful targets for therapeutic intervention in human cancers. ..
  16. Temporally controlled oncogene expression in a novel pancreatic cancer model
    Kay Uwe Wagner; Fiscal Year: 2012
    ....
  17. Myc Oncogene Mutations and Polymorphisms in Cancer
    MICHAEL DAVID COLE; Fiscal Year: 2013
    ..The goal of the project is to understand how mutations change c-myc function in some cancers and how inherited variations near c-myc in the human genome can increase the risk of cancer. ..
  18. Comparative Mechanisms of Genomic Instability
    Karen M Vasquez; Fiscal Year: 2010
    ..For example, translocations resulting in overexpression of the BCL-2 and c-MYC genes are the hallmarks of follicular B-cell lymphoma and Burkitt's lymphoma, respectively...
  19. Structure-based design of novel low molecular weight c-Myc inhibitors
    EDWARD VICTOR PROCHOWNIK; Fiscal Year: 2013
    ..abstract_text> ..
  20. Hybridization of Promoter DNA Targets in Chromatin to Discover Regulatory Protein
    LINDA B MC GOWN; Fiscal Year: 2010
    ....
  21. Metabolism, protein and miRNA cross-talk in cell cycle and tumor progression
    David M Hockenbery; Fiscal Year: 2013
    ....
  22. Targeting c-Myc and Akt with PP2A reactivation therapy for the treatment of breas
    Dale J Christensen; Fiscal Year: 2013
    ....
  23. "Oncorequisite" Genes in MYC-mediated Transformation
    Hui Feng; Fiscal Year: 2013
    ..The rationale and feasibility of this approach are well-illustrated by my data acquired during the K99 phase. ..
  24. Investigation of Myc Oncoprotein in B lymphocyte Development and Transformation
    Brian M Iritani; Fiscal Year: 2012
    ..Experiments described in this proposal will utilize transgenic and knockout mice to help elucidate the normal functions of Myc in lymphocyte development, and how deregulated Myc potently stimulates cells to divide in cancer. ..
  25. Identification and Characterization of Liver Cancer Stem Cells
    DAVID BELLOVIN; Fiscal Year: 2010
    ..The ultimate consequences of this study would be to gain insight into the development of liver cancer, while potentially identifying novel therapeutic targets for this especially lethal disease. ..
  26. Zebrafish Chemical and Classical Genetics Approach to the Pathogenesis of T-ALL
    Alejandro Gutierrez; Fiscal Year: 2012
    ....
  27. Disruption of HLA Class II-Mediated Immune Recognition of B-Cell Lymphomas
    Azizul Haque; Fiscal Year: 2013
    ..The elucidated findings will likely spur development of novel strategies to restore CD4+ T cell recognition and clearance of BL and other B-cell lymphomas. ..
  28. Oncogenic cooperation restrained by a putative internal antagonist in miR-17-92
    ERICH SABIO; Fiscal Year: 2013
    ..Due to the extensive association between miRNA dysregulation and cancer, the valuable insights we will gain through these studies will have a broad impact on global health. ..
  29. (PQ6) Molecular Mechanisms of Dormancy in MYC-Driven Medulloblastoma
    Yanxin Pei; Fiscal Year: 2013
    ..If these studies are successful, they will help identify novel approaches to preventing tumor relapse in MYC-driven MB and other malignancies. ! ..
  30. Functional analysis of transcriptional program regulated by the c-MYC oncoprotein
    Steven B McMahon; Fiscal Year: 2012
    ..each year. Understanding the cellular changes induced by MYC will provide us with novel targets for therapeutic intervention in these patients. The studies proposed here are aimed at a precise mechanistic delineation of the MYC pathway. ..
  31. Regulation of Telomerase by Sphingolipid Signaling in Lung Cancer
    Besim Ogretmen; Fiscal Year: 2013
    ..Moreover, these studies will lead to the development of mechanism-based novel therapeutic strategies for improved NSCLC treatment to selectively inhibit oncogenic SK2/S1P/hTERT/c-Myc axis without affecting telomere-length regulation. ..
  32. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
    ....
  33. C-MYC EXPRESSION AND APOPTOSIS IN B CELLS
    GAIL SONENSHEIN; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  34. Molecular and Cellular Basis of Oncogene Addiction
    Dean W Felsher; Fiscal Year: 2010
    ..The results of our proposed experiments will have important implications for the mechanisms by which the MYC oncogene maintains tumorigenesis and the development of new therapies for the treatment of cancer. ..
  35. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..The lead compounds resulting from these studies will then be translated to a separate collaborative application for a Phase I/II clinical trial. ..
  36. ANALYSIS OF CELLULAR ONCOGENES IN VIRUS-INDUCED TUMORS
    David Steffen; Fiscal Year: 1992
    ..Clones of normal and virally-altered c-myc genes will be fused to the reporter gene chloramphenicol acetyltransferase (CAT), and the activities of a series of ..
  37. Chromatin Insulator Function at the C-myc Gene
    Anton Krumm; Fiscal Year: 2007
    ..The results will broaden our understanding of the role of chromatin elements in the specific regulation and nuclear organization of mammalian oncogenes in normal and malignant cells. ..
  38. MOLECULAR STUDIES ON THE EVOLUTION OF B-CELL LYMPHOMAS
    CHARLOTTE GAUWERKY; Fiscal Year: 1991
    ..These experiments should provide important insights into the mechanisms involved in the control of B- and T-cell proliferation...
  39. TARGETING NATIVE DOUBLE HELIX STRUCTURES AND FUNCTIONS
    DAVID ZARLING; Fiscal Year: 1999
    ....
  40. NOVEL THERAPEUTIC APPROACHES IN HIV-ASSOCIATED LYMPHOMAS
    Thomas Kipps; Fiscal Year: 1993
    ..Molecular biology, virology, and immunology have identified promising experimental therapies for HIV associated NHL. Collaboration between basic and clinical science offers hope of identifying new effective therapies...
  41. DEREGULATION BY HU PROTEINS IN LUNG CANCER
    Ite Laird Offringa; Fiscal Year: 2002
    ..They can bind to the destabilizing sequences of labile proto-oncogene mRNAs, such as those of the family of myc genes. myc genes are frequently oncogenically activated in SCLC and neuroblastoma by events that increase the levels ..
  42. ANTIBODIES TO INVESTIGATE AND TREAT NEUROBLASTOMA
    Christopher Frantz; Fiscal Year: 1992
    ..The proposed investigations will define the role of the N-myc oncogene in the growth, differentiation and metastasis of neuroblastoma...
  43. POST TRANSCRIPTIONAL CONTROL OF THE HUMAN N MYC GENE
    William Carroll; Fiscal Year: 2002
    ....
  44. Lymphoma Defined Cytogenetically for Epidemiologic Study
    Brian Chiu; Fiscal Year: 2009
    ..We propose to define NHL according to rearrangements of the BCL2, BCL6, and C-MYC genes because cytogenetic studies have shown that recurring chromosomal abnormalities leading to the deregulation of ..
  45. TRANSCRIPTIONAL REPRESSION AND CELL CYCLE MECHANISMS
    Amy Yee; Fiscal Year: 2000
    ....
  46. MECHANISMS OF C-MYC ONCOGENE ACTION
    SVEND FREYTAG; Fiscal Year: 1992
    ..This will be determined by examining various mutant c-myc genes that lack these activities for their ability to inhibit 3T3-L1 cell differentiation and to repress pro alpha 2(1)..
  47. N-myc Targeted Therapeutics for Childhood Neuroblastoma
    CATHERINE BURKHART; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. COOPERATIVE EFFECTS OF VIRAL AND CELLULAR ONCOGENES
    ELIZABETH TAPAROWSKY; Fiscal Year: 1993
    ....
  49. FLUORESCENT TISH PROBES FOR CANCER REVELANT SEQUENCES
    JACQUES FRESCO; Fiscal Year: 2004
    ..Amplification of erbB-2 (HER-2/neu) and N-myc genes is particularly correlated with poor prognosis in breast and cervical cancers and neuroblastoma, respectively...
  50. FLUORESCENT TISH PROBES FOR CANCER REVELANT SEQUENCES
    JACQUES FRESCO; Fiscal Year: 2001
    ..Amplification of erbB-2 (HER-2/neu) and N-myc genes is particularly correlated with poor prognosis in breast and cervical cancers and neuroblastoma, respectively...
  51. INTERACTION OF SRC AND OTHER PROTEINS IN TRANSFORMATION
    David Shalloway; Fiscal Year: 1992
    ..We will transfect sense and antisense plasmids which express the c-src, p27 gap junction protein, E1A, plt, v-myc genes and their mutants into rodent cells and compare the resultant effects on gap junction communication and other ..
  52. GENETICS OF RADIATION RESISTANCE
    William McKenna; Fiscal Year: 1992
    ..The karyotypic changes induced by oncogene transfection will be correlated with the radioresistant phenotype. The species specificity of oncogene induced radioresistance will be explored...
  53. EGF FAMILY INDUCTION OF MAMMARY HYPERPLASIAS AND TUMORS
    Robert Dickson; Fiscal Year: 2000
    ....
  54. Analyzing Myc function in neural cancers and development
    Paul Knoepfler; Fiscal Year: 2009
    ..The general goal of this proposal is to elucidate the mechanism by which deregulation of myc genes leads to tumorigenesis...
  55. REGULATION OF NEUROBLASTOMA DIFFERENTIATION IN CULTURE
    Emil Bogenmann; Fiscal Year: 1991
    ..We will attempt to study a link between mechanisms controlling development and genetic elements with transforming potential...
  56. Targeting Biologically Relevant DNA and RNA with Guanine Quadruplex Forming PNA's
    BRUCE ARMITAGE; Fiscal Year: 2009
    ..Finally, PNAs will be introduced into mammalian cell culture to study inhibition of c-MYC transcription, alteration of hTERT pre-mRNA splicing and inhibition of telomerase activity. ..
  57. CHROMOSOME TRANSLOCATED ONCOGENES AND NEOPLASIA
    KENNETH MARCU; Fiscal Year: 1993
    ..Modified myc genes will be stably integrated into lymphoid tumor cells which express either normal or truncated myc RNAs...
  58. Molecular Genetics of Cervical Cancer Progression
    Murty Vundavalli; Fiscal Year: 2004
    ..Molecular genetic studies to date in CC have identified amplification of oncogenes such as ERBB2, c-myc genes and frequent allelic imbalances affecting multiple chromosomal arms such as 2q, 3p, 4q, 5p, 6p, and 11q...
  59. Multi step tumorigenesis, control of cell cycle entry
    Hartmut Land; Fiscal Year: 2005
    ..This work will provide insight into developing signaling pathway-based strategies for cancer therapy in humans. ..
  60. Regulation of Oncogenesis and Apoptosis by Wnt
    Cun Yu Wang; Fiscal Year: 2007
    ..The findings from this proposal will yield new insights into Wnt-associated human cancer and provide the molecular basis for human cancer treatment. ..
  61. FUNCTION OF THE ONCOGENE BMI-1 IN CANCER
    Kenneth Cohen; Fiscal Year: 2000
    ..These studies should clarify the role of bmi-1 in cancer development. ..
  62. BASIC SCIENCE TRAINING IN HEMATOLOGY & MOLECULAR GENETIC
    Robert Tepper; Fiscal Year: 1991
    ..The development of an experimental inpatient Hematology Clinical Research Unit is in the planning stages at the MGH; it is envisioned that the candidate would play a role, via liaison basic research and/or teaching, in such a unit...
  63. INDUCTION OF HUMAN NEUROBLASTOMA DIFFERTIATION
    Charles Reynolds; Fiscal Year: 1990
    ..Methods developed for assessing neuroblastoma differentiation in vitro will be valuable in assessing the effects of differentiation inducers in vivo during clinical trials...