fms genes

Summary

Summary: Family of genes originally isolated from the Susan McDonough strain of feline sarcoma virus (SARCOMA VIRUSES, FELINE). The proto-oncogene fms (c-fms) codes for the MCSF receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR). The oncogene fms (v-fms) codes for ONCOGENE PROTEIN GP140(V-FMS) which is a mutated form of the MCSF. The human c-fms gene is located between 5q33.2 and 5q33.3.

Top Publications

  1. ncbi Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes
    Yue Xie
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:4687-98. 2003
  2. ncbi Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
  3. ncbi SGK1, a potential regulator of c-fms related breast cancer aggressiveness
    Jacob Tangir
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Exp Metastasis 21:477-83. 2004
  4. ncbi CSF-1 deficiency in mice results in abnormal brain development
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 122:2661-72. 1996
  5. pmc Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
    Hiromi Tagoh
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    EMBO J 23:4275-85. 2004
  6. pmc PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
    R P DeKoter
    Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    EMBO J 17:4456-68. 1998
  7. ncbi A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression
    S R Himes
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    J Leukoc Biol 70:812-20. 2001
  8. ncbi Clone and expression of mutant M-CSF and its receptor from human leukemic cell line J6-1
    Ge Li
    National Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, PR China
    Leuk Res 26:377-82. 2002
  9. ncbi Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury
    Chia Jen Siao
    Department of Pharmacological Sciences, Program in Molecular and Cellular Pharmacology, University Medical Center at Stony Brook, Stony Brook, New York 11794 8651, USA
    J Neurosci 23:3234-42. 2003
  10. ncbi Differential expression of protooncogenes in human germ cell tumors of the testis
    T Shuin
    Department of Urology, Yokohama City University School of Medicine, Japan
    Cancer 73:1721-7. 1994

Research Grants

  1. PHARMACOLOGIC AND MOLECULAR CONTROL OF C-JUN IN LEUKEMIA
    MATTHEW SHERMAN; Fiscal Year: 1992
  2. CSF-1 AND DRUG RESISTANCE IN REPRODUCTIVE CANCERS
    SETSUKO CHAMBERS; Fiscal Year: 1991
  3. CSF-1 RECEPTOR SIGNALLING AND G1 PROGRESSION
    Martine Roussel; Fiscal Year: 2001
  4. Predicting Melanoma Response to BAY 43-9006/Chemotherapy
    Harriet Kluger; Fiscal Year: 2008
  5. Tyrosine Kinase Pathways in Autoimmune Arthritis.
    Ricardo Paniagua; Fiscal Year: 2008

Scientific Experts

  • Ricardo T Paniagua
  • H McGlynn
  • Dong Hua Yang
  • Brendan J Jenkins
  • Martine Roussel
  • Biljana Jekic
  • Harriet Kluger
  • P Dickie
  • Roland P Bourette
  • C Andre
  • Dmitry A Ovchinnikov
  • Maryann B Flick
  • Setsuko K Chambers
  • E Sapi
  • MATTHEW SHERMAN
  • Hiromi Tagoh
  • Faisel M Abu-Duhier
  • Yue Xie
  • Constanze Bonifer
  • Diana Panesso
  • Cesar A Arias
  • Barbara E Murray
  • Jessica R Galloway-Peña
  • N Brownlow
  • Simon Chu
  • Pietro Bertino
  • Amanda Sierra
  • Hanna Krysinska
  • Sandra H Burnett
  • Zhenqiang Yao
  • Jia Li
  • Nicola Wilson
  • Stewart R Himes
  • S D Yogesha
  • Robert L Ilaria
  • Akiko Satou
  • T N Kuznetsova
  • Jacob Tangir
  • Maddalena Cross
  • David A Hume
  • Pascal Lefevre
  • Anne C Goodeve
  • Ian R Peake
  • John T Reilly
  • Chia Jen Siao
  • George A Follows
  • Stuart K Calderwood
  • Changmin Chen
  • N J Dibb
  • Ge Li
  • D A Hume
  • S R Himes
  • R A Padua
  • Altagracia Merentes
  • Lorena Diaz
  • Jessica Galloway-Peña
  • Javier A Adachi
  • Jinnethe Reyes
  • Carlos Carrillo
  • K Tanaka
  • Jeannete Zurita
  • Sandra Rincon
  • Manuel Guzman
  • Sreedhar R Nallapareddy
  • George M Eliopoulos
  • C Taylor
  • P W Manley
  • N Suzuki
  • H Saravanapavan
  • A E Russell
  • J M Murray
  • H Manome
  • A Takahashi
  • M Wiesmann
  • Maria Alexiadis
  • Peter J Fuller
  • Karen Bulloch
  • Richard Ingram
  • Harinder Singh
  • Peter Laslo
  • Maarten Hoogenkamp
  • Giancarlo Tassi
  • Serena Germano
  • Giovanni Gaudino
  • Andres C Gottfried-Blackmore
  • Luciano Mutti
  • Bruce S McEwen
  • Dario Barbone
  • Camillo Porta
  • Sabrina Pinato

Detail Information

Publications119 found, 100 shown here

  1. ncbi Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes
    Yue Xie
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:4687-98. 2003
    ..Mapping the structural domains involved in this process should permit further characterization of molecular mechanisms that mediate repression...
  2. ncbi Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
    ..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
  3. ncbi SGK1, a potential regulator of c-fms related breast cancer aggressiveness
    Jacob Tangir
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Exp Metastasis 21:477-83. 2004
    ..This finding may have implications for potential therapeutic interventions aimed at decreasing the aggressiveness of breast cancer cells...
  4. ncbi CSF-1 deficiency in mice results in abnormal brain development
    M D Michaelson
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 122:2661-72. 1996
    ..The effects of CSF-1 on cultured embryonic neural cells, the developmentally appropriate expression of CSF-1 and its receptor, and the neurological abnormalities in op/op mice suggest a role for CSF-1 in brain development...
  5. pmc Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
    Hiromi Tagoh
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    EMBO J 23:4275-85. 2004
    ..However, even at mature B cell stages, c-fms chromatin is still in a poised conformation and c-fms expression can be re-activated by conditional deletion of the transcription factor Pax5...
  6. pmc PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
    R P DeKoter
    Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    EMBO J 17:4456-68. 1998
    ..1 into mutant progenitors restores responsiveness to myeloid-specific cytokines and development of mature granulocytes and macrophages. Thus PU.1 controls myelopoiesis by regulating both proliferation and differentiation pathways...
  7. ncbi A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression
    S R Himes
    Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
    J Leukoc Biol 70:812-20. 2001
    ..Removal of FIRE abolished reporter gene expression, revealing a suppressive activity in the remaining intronic sequences. Hence, FIRE is shown to be a key regulatory element in the fms gene...
  8. ncbi Clone and expression of mutant M-CSF and its receptor from human leukemic cell line J6-1
    Ge Li
    National Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, PR China
    Leuk Res 26:377-82. 2002
    ..COS-7 cells transfected with MAF-J6-1-R show obvious protein tyrosine kinase (PTK) activity. Our present work shows that MAF-J6-1 and its receptor are mutations of M-CSF and its receptor...
  9. ncbi Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury
    Chia Jen Siao
    Department of Pharmacological Sciences, Program in Molecular and Cellular Pharmacology, University Medical Center at Stony Brook, Stony Brook, New York 11794 8651, USA
    J Neurosci 23:3234-42. 2003
    ..We suggest that an approach to attenuate microglia-mediated neuronal death in vivo might be to pharmacologically prevent microglial activation...
  10. ncbi Differential expression of protooncogenes in human germ cell tumors of the testis
    T Shuin
    Department of Urology, Yokohama City University School of Medicine, Japan
    Cancer 73:1721-7. 1994
    ..It has been suggested that tumorigenesis of the germ cell tumor of the testis includes abnormal and developmentlike differentiation of primordial germ cells to several mature type tumors...
  11. pmc A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene
    Hanna Krysinska
    University of Leeds, Leeds Institute of Molecular Medicine, St James s University Hospital, Wellcome Trust Brenner Building, Leeds LS9 7TF, United Kingdom
    Mol Cell Biol 27:878-87. 2007
    ..The two-step mechanism of developmental gene activation that we describe here may be utilized to regulate gene activity in a variety of developmental pathways...
  12. pmc Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation
    X Yue
    Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 13:3191-201. 1993
    ..The results suggest that expression of the c-fms gene in macrophages is controlled by sequences in intron 2 that act by regulating transcription elongation...
  13. ncbi Colony stimulating factor-1 expression in human glioma
    R L Alterman
    Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10461
    Mol Chem Neuropathol 21:177-88. 1994
    ..We conclude that coexpression of CSF-1 and its receptor in some human gliomas hints at a possible autocrine or paracrine growth stimulatory role for CSF-1; however, its function in the mammalian CNS remains to be elucidated...
  14. ncbi Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice
    Dmitry A Ovchinnikov
    Institute for Molecular Bioscience, Bldg 80, University of Queensland, Brisbane, Queensland 4072, Australia
    J Leukoc Biol 83:430-3. 2008
    ..The new mouse line provides a useful tool for overexpression of transgenes in cells of the myeloid lineage, while simultaneously labeling them by ECFP expression...
  15. ncbi Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis
    N Brownlow
    Leukemia 22:649-52. 2008
  16. pmc Reassessment of the murine c-fms proto-oncogene sequence
    N de Parseval
    ICGM, INSERM U363, Hopital Cochin, Paris, France
    Nucleic Acids Res 21:750. 1993
  17. ncbi Microglia derived from aging mice exhibit an altered inflammatory profile
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Glia 55:412-24. 2007
    ..Gender differences were not overall observed across the treatments (age, LPS). The low but sustained production of pro-inflammatory cytokines by aging microglia may have a profound impact in the brain aging process...
  18. ncbi Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors
    Simon Chu
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Gynecol Oncol 108:182-90. 2008
    ..A recent case report of a patient with advanced recurrent GCT responding to the tyrosine kinase inhibitor, imatinib mesylate prompted us to explore a role for these therapies in GCT...
  19. ncbi Osteoclast molecular phenotyping by random cDNA sequencing
    D Sakai
    Molecular Biology Program, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    Bone 17:111-9. 1995
    ..I. = 1.2-4.9%), c-fms and ribosomal protein L18 (95% C.I. = 0.8-4.3%), and cathepsin-OC2, cyclophilin, delta-aminolevulinate synthetase, 16S mitochondrial rRNA, and two novel gene sequences (95% C.I. = 0.5-3.6%)...
  20. ncbi The first intron of human c-fms proto-oncogene contains a processed pseudogene (RPL7P) for ribosomal protein L7
    E Sapi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 22:641-5. 1994
    ..We also showed that despite the fact that the 5' flanking region of the RPL7 sequence contains a potential TATA box upstream of an intact open reading frame, this pseudogene (RPL7P) is not actively transcribed...
  21. ncbi [Deletional polymorphism of the 11th intron of the human c-fms gene: allele frequency in certain Russian populations and possible functional significance]
    T N Kuznetsova
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia
    Genetika 40:102-12. 2004
    ..In case of trichmoniasis, the frequency of rare allele was 2.4 times lower, and in case of acute bronchitis it was 2.1 times higher than in the control sample...
  22. pmc Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United States
    Jessica R Galloway-Peña
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
    J Infect Dis 200:1566-73. 2009
    ..The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments...
  23. pmc Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells
    A Rambaldi
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    J Clin Invest 81:1030-5. 1988
    ..These results demonstrate that leukemic myeloblasts from a subset of patients with AML express transcripts for both the CSF-1 and CSF-1 receptor genes, often in the same leukemic cells in vitro...
  24. ncbi c-FMS mutational analysis in acute myeloid leukaemia
    Faisel M Abu-Duhier
    Br J Haematol 123:749-50. 2003
  25. ncbi Sporadic amplification of the c-fms proto-oncogene in human musculoskeletal sarcomas
    J S Castresana
    Department of Tumor Pathology, Karolinska Hospital, Stockholm, Sweden
    Anticancer Res 13:807-10. 1993
    ..The fact that this structural abnormality of the c-fms gene was only detected in liposarcomas might point to an uncommon but tissue-specific phenomenon...
  26. ncbi Interleukin-3 and granulocyte-macrophage colony-stimulating factor inhibits tumor necrosis factor (TNF)-alpha-induced osteoclast differentiation by down-regulation of expression of TNF receptors 1 and 2
    S D Yogesha
    National Center for Cell Science, University of Pune Campus, Ganeshkhind Rd, Pune 411 007, India
    J Biol Chem 280:11759-69. 2005
    ..In summary, we provide the first evidence that IL-3 and GM-CSF block TNF-alpha-induced osteoclast differentiation by down-regulation of mRNA and surface expression of TNFR1 and TNFR2...
  27. pmc Modulation of c-fms proto-oncogene in an ovarian carcinoma cell line by a hammerhead ribozyme
    Y Yokoyama
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan
    Br J Cancer 76:977-82. 1997
    ..These results suggest that the ribozyme against GUC in codon 18 of c-fms mRNA is a promising tool for blocking the autocrine loop of M-CSF in ovarian epithelial carcinoma...
  28. ncbi FMS hemizygosity in myeloid dysplasia and acute myeloid leukemia with chromosomal aberration del(5)(q) demonstrated by polymerase chain reaction
    M Pfeilstöcker
    Third Medical Department, Hanusch Hospital, Vienna, Austria
    J Mol Med (Berl) 73:403-7. 1995
    ..PCR-based analysis can be used for primary diagnosis in addition to cytogenetic evaluation and for follow-up in patients with del(5)(q) aberration...
  29. ncbi Expression of functional human CSF-1 receptors on mouse bone marrow erythroid progenitor cells
    G Mouchiroud
    , UMR CNRS 106, , Villeurbanne, France
    C R Acad Sci III 316:1290-6. 1993
    ....
  30. ncbi [Myelodysplastic syndromes--clinical and biological features]
    Y Yoshida
    Dept of Internal Medicine, Faculty of Medicine, Kyoto University
    Gan To Kagaku Ryoho 21:135-40. 1994
    ..The emergence and progression of the myelodysplastic clone have been reviewed in the light of the multistep theory of human carcinogenesis...
  31. pmc c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis
    Ricardo T Paniagua
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, CCSR 4135, 269 Campus Drive, Stanford, CA 94305, USA
    Arthritis Res Ther 12:R32. 2010
    ..However, which of the imatinib-targeted kinases is the principal culprit in disease pathogenesis remains unknown. Here we examine the role of c-Fms in autoimmune arthritis...
  32. pmc Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitals
    Diana Panesso
    Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia
    J Clin Microbiol 48:1562-9. 2010
    ..All VREfm isolates were evaluated for the presence of 16 putative virulence genes (14 fms genes, the esp gene of E. faecium [espEfm], and the hyl gene of E...
  33. ncbi Expression of the colony-stimulating factor 1 receptor in B lymphocytes
    A H Baker
    Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Oncogene 8:371-8. 1993
    ..Thus, FMS may play a role in the normal function of B lymphocytes and, because of its potential oncogenic activity, may contribute to the pathogenesis of malignancies of this cell type...
  34. pmc Preliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexed
    Pietro Bertino
    DISCAFF Department and DFBC Center, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
    Thorax 62:690-5. 2007
    ..A study was undertaken to assess whether imatinib alone or combined with chemotherapeutic agents may be effective for treating mesothelioma...
  35. ncbi Mechanism of differential inhibition of factor-dependent cell proliferation by transforming growth factor-beta 1: selective uncoupling of FMS from MYC
    A R Chen
    Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Blood 81:2539-46. 1993
    ..Therefore, FMS and the GM-CSF receptor induce c-myc via signal transduction pathways that differ in that only the former is inhibited by TGF-beta 1. This inhibition may account for the selective growth regulation by TGF-beta 1...
  36. ncbi Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis
    Faisel M Abu-Duhier
    Academic Unit of Haematology, Division of Genomic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Br J Haematol 120:464-70. 2003
    ..Intronic primers were used to amplify the entire coding region of both the C-KIT and C-FMS genes, and selected regions of the FLT3 gene...
  37. ncbi The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages
    Stewart R Himes
    CRC for Chronic Inflammatory Disease, Institute for Molecular Biosciences, Queensland Biosciences Precinct, Bldg 80, Services Rd, University of Queensland, Brisbane, Queensland 4072, Australia
    Oncogene 24:5278-86. 2005
    ..The runx1 and c-fms genes showed an identical pattern of expression in mature macrophages...
  38. ncbi Transcriptional regulation of the c-fms proto-oncogene mediated by granulocyte/macrophage colony-stimulating factor (GM-CSF) in murine cell lines
    G Helftenbein
    Institut fur Virologie, Justus Liebig Universitat Giessen, Germany
    Oncogene 12:931-5. 1996
    ..Furthermore, a 2.1 kb genomic fragment containing the c-fms proximal promoter directs GM-CSF-inducible expression of a reporter gene, suggesting a regulation of c-fms gene expression on the transcriptional level...
  39. ncbi Oncogenes belonging to the CSF-1 transduction pathway direct p53 tumor suppressor effects to monocytic differentiation in 32D cells
    R Martinelli
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 15:607-11. 1997
    ..These data strongly support the idea that wt-p53 suppressing effects result from interactions between p53 activity and the signaling pathways activated in different transformed cells...
  40. ncbi Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1beta complex
    Akiko Satou
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
    FEBS Lett 572:211-5. 2004
    ..Of the two promoters, pE1 and pE2, in the c-fms gene, pE1 promoter activity was found to be activated in an E-box-dependent manner...
  41. ncbi [Molecular biology of ovarian cancer]
    K Tanaka
    Dept of Obstetrics and Gynecology, Niigata University School of Medicine, Japan
    Gan To Kagaku Ryoho 26:2162-7. 1999
    ..Among the genes searched to date for abnormalities related to ovarian cancer, BRCA1 is thought to be the most likely candidate for having a causal relation with the familial ovarian cancer syndrome...
  42. ncbi Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathy
    Peter Dickie
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Virology 322:69-81. 2004
    ..However, the unique contribution of macrophage-specific Vpr expression in the development of glomerular disease was underscored by the induction of FGS in multiple murine lines bearing a c-fms/vpr transgene...
  43. ncbi Oncogenic potential of the c-FMS proto-oncogene (CSF-1 receptor)
    Martine F Roussel
    Dept of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Cell Cycle 2:5-6. 2003
  44. ncbi Heterogeneity among cells that express osteoclast-associated genes in developing bone
    R Jemtland
    Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston 02114, USA
    Endocrinology 139:340-9. 1998
    ..Alternatively, type IV collagenase-positive and TRAP/c-fms-positive cells may represent distinct subpopulations of cells of the osteoclast lineage...
  45. ncbi Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders
    M M Le Beau
    Science 231:984-7. 1986
    By in situ chromosomal hybridization, the GM-CSF and FMS genes were localized to human chromosome 5 at bands q23 to q31, and at band 5q33, respectively...
  46. pmc Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma
    R N Salomon
    New England Medical Center, Boston, MA 02111
    Proc Natl Acad Sci U S A 89:2814-8. 1992
    ..Macrophages within the advanced human atheroma appear to exhibit a selective program of activation as they express high levels of apoE, whereas overall levels of interleukin 1 or 6 mRNAs in plaques are not elevated...
  47. ncbi Lineage-specific methylation of the c-fms gene in blood cells and macrophages
    J Felgner
    Institute of Pathology, Kiel, Germany
    Leukemia 6:420-5. 1992
    ....
  48. ncbi Molecular genetic aspects of myelodysplastic syndromes
    C R Bartram
    Department of Pediatrics II, University of Ulm, Germany
    Hematol Oncol Clin North Am 6:557-70. 1992
    ..However, the clinical relevance of molecularly defined parameters has already been established for their use as clonal markers in determining the mode of action and efficiency of different therapeutic approaches...
  49. ncbi Regulation of hematopoietic cell function by protein tyrosine kinase-encoding oncogenes, a review
    C J Punt
    Department of Medical Oncology, University Hospital Nijmegen, The Netherlands
    Leuk Res 16:551-9. 1992
    ..This review summarizes the mechanism of action of PTKs from the major subclasses and the involvement of PTK-encoding oncogenes in the regulation of hematopoietic cell function...
  50. ncbi Gene expression of macrophage colony-stimulating factor and its receptor in human placenta and decidua
    F Saji
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Am J Reprod Immunol 24:99-104. 1990
    ..These findings indicate that, in an autocrine and/or paracrine manner, M-CSF is deeply involved in the local proliferation and differentiation of cells at the materno-fetal interface, and support the placental immunotrophism hypothesis...
  51. ncbi Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia
    K Yamamoto
    First Department of Medicine, Tokyo Medical and Dental University, Japan
    Am J Hematol 40:252-8. 1992
    ..It may be suggested that leukemogenesis of APL is different from other subtypes of acute myelogenous leukemia, and multistep leukemogenesis may not be a prevalent feature in APL...
  52. ncbi The biological effects of macrophage-colony-stimulating factor induced by progestin on growth and differentiation of endometrial adenocarcinoma cells
    T Kimura
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    Int J Cancer 49:229-33. 1991
    ..These effects of M-CSF on endometrial cancer cells are similar to those of progestins, so the effects of progestins on these cells are, at least in part, probably mediated by M-CSF in an autocrine or paracrine manner...
  53. ncbi Assessment of expression of the receptor for colony-stimulating factor-1 (fms) in bovine trophoblast
    J L Beauchamp
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Biol Reprod 45:811-7. 1991
    ..The data do support a universal role for this protein during mammalian placental development...
  54. ncbi The v-abl, c-fms, or v-myc oncogene induces gamma radiation resistance of hematopoietic progenitor cell line 32d cl 3 at clinical low dose rate
    T J Fitzgerald
    Department of Radiation Oncology, University of Massachusetts Medical Center, Worcester 01655
    Int J Radiat Oncol Biol Phys 21:1203-10. 1991
    ..The data on cell line 32D cl 3 may correlate with the radioresistance of v-abl expressing human hematopoietic cell malignancies treated by irradiation therapy...
  55. pmc Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7
    D Orlic
    Hematopoiesis Section, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:4601-5. 1995
    ..These findings also indicate that GATA-2, p45 NF-E2, and c-myb activities may be involved in PHSC maintenance or proliferation...
  56. ncbi Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase
    N F Zander
    Department of Biochemistry, University of Washington, Seattle 98195
    Oncogene 8:1175-82. 1993
    ..These results indicate that coexpression of the deregulated, soluble tyrosine phosphatase with a constitutively active, oncogenic receptor tyrosine kinase leads to the suppression of the transformed phenotype...
  57. ncbi Monocyte infiltration and c-fms expression in hearts of spontaneously hypertensive rats
    H Haller
    Department of Medicine and Nephrology, Steglitz University Hospital, Free University of Berlin, Germany
    Hypertension 25:132-8. 1995
    ..We suggest that mononuclear cell recruitment and induction of c-fms may play a role in the development of hypertension-associated myocardial hypertrophy...
  58. ncbi Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development
    R J Arceci
    Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Dev Biol 151:1-8. 1992
    ..The patterns of CSF-1/c-fms mRNA and SF/c-kit mRNA expression are consistent with the hypothesis that these two ligand/receptor systems may act in a compensatory or synergistic manner during preimplantation development...
  59. ncbi Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
    F Birg
    Laboratory of Molecular Hematology, , Marseille, France
    Blood 80:2584-93. 1992
    ....
  60. ncbi cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model
    Harriet M Kluger
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Lab Invest 84:320-31. 2004
    ..These genes provide a basis for further studies of metastatic progression and local invasiveness, and can be evaluated as therapeutic targets...
  61. pmc Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
    Mol Cell Biol 24:1453-63. 2004
    ....
  62. ncbi The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update
    Eva Sapi
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Exp Biol Med (Maywood) 229:1-11. 2004
    ....
  63. ncbi Tyrosine kinases in AML: where do they fit in?
    Robert L Ilaria
    Leuk Res 28:217-8. 2004
  64. pmc Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors
    D Metcalf
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 89:2819-23. 1992
    ..This phenomenon of synergistic suppression may have relevance for the future clinical use of combinations of CSFs, because a potentially similar suppression is also observable with some normal macrophage progenitor cells...
  65. ncbi [Molecular abnormalities and clonality in myelodysplastic syndromes]
    P Fenaux
    Service des Maladies du Sang, CHU de Lille, France
    Pathol Biol (Paris) 45:556-60. 1997
    ..This opens up the promising possibility that transplantation of autologous multipotent stem cells may be an effective therapeutic approach...
  66. pmc Epigenetic consequences of AML1-ETO action at the human c-FMS locus
    George A Follows
    Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
    EMBO J 22:2798-809. 2003
    ..Our experiments provide for the first time a direct insight into the chromatin structure of an AML1-ETO-bound target gene...
  67. ncbi Amplification of the c-myc proto-oncogene in human chondrosarcoma
    J S Castresana
    Department of Tumor Pathology, Karolinska Hospital, Stockholm, Sweden
    Diagn Mol Pathol 1:235-8. 1992
    ..The clinical significance of this gene amplification remains to be established...
  68. ncbi [Detection of homologous oncogene sequences in the genome of Plasmodium falciparum]
    C Macary
    , La Tronche
    C R Acad Sci III 312:37-42. 1991
    ..The oncogene study will allow an understanding of the biology of the parasite and particularly the host-parasite relationships which allow P. falciparum to develop, keeping the established harmony between the parasite and his host...
  69. ncbi Gene mutations in myelodysplasia
    A Jacobs
    University of Wales College of Medicine, Cardiff
    Leuk Res 16:47-50. 1992
    ..The data suggest the inability of mutant ras or fms genes alone to produce observable preleukaemic changes but that subjects with these mutations may be predisposed to ..
  70. ncbi [Parallel loss of c-FMS and GM-CSF genes in myeloid leukemias with 5q-chromosome]
    K Tanaka
    Department of Hematology, Hiroshima University
    Rinsho Ketsueki 32:931-7. 1991
    ..These findings suggest that c-FMS oncogene and GM-CSF gene locating in the critical region on chromosome 5 seem to have an important role in the process of leukemogenesis...
  71. ncbi Multilineage phenotypes of interleukin-3-dependent progenitor cells
    A M Ford
    Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, England
    Blood 79:1962-71. 1992
    ....
  72. pmc A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling
    Maddalena Cross
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia
    Biochem J 380:243-53. 2004
    ..The phosphorylation of p110 myosin XVIIIA by CSF-1 may alter its cellular localization or target its association with other proteins...
  73. ncbi The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma
    Dong Hua Yang
    Department of Gastroenterology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China
    Hepatobiliary Pancreat Dis Int 3:86-9. 2004
    ..This study is to investigate the relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma (HCC) and to clarify the mechanism of HCC...
  74. ncbi Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice
    Jia Li
    Department of Development and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genesis 44:328-35. 2006
    ..This conditional allele will prove extremely valuable to study the spatial and temporal roles of CSF-1R...
  75. ncbi E2a/Pbx1 oncogene inhibits terminal differentiation but not myeloid potential of pro-T cells
    R P Bourette
    Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, Villeurbanne Cedex, France
    Oncogene 26:234-47. 2007
    ..Finally, additional experiments suggested that PU.1 and eight twenty-one transcriptional regulators might be implicated in the mechanisms of oncogenesis by E2a/Pbx1...
  76. ncbi Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome
    Biljana Jekic
    Institute of Biology and Human Genetics, School of Medicine, 26 Visegradska Str, 11000 Belgrade, Serbia and Montenegro
    Cancer Genet Cytogenet 166:163-5. 2006
    ..Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults...
  77. ncbi Alteration of the c-fms gene in a blood sample from a Thorotrast individual
    F R Collart
    Biological and Medical Research Division, Argonne National Laboratory, IL 60439
    Health Phys 63:27-32. 1992
    ....
  78. ncbi [Activation of protooncogenes by point mutations in hematological malignancies]
    T Goto
    Third Department of Internal Medicine, Faculty of Medicine, University of Kyushu
    Nippon Rinsho 50:1335-40. 1992
    ..Furthermore, mutations in the 3' border of the exon 1 of c-myc are frequent, and may play an additional role in pathogenesis of Burkitt lymphoma...
  79. ncbi Development of peritoneal adhesions in macrophage depleted mice
    Sandra H Burnett
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
    J Surg Res 131:296-301. 2006
    ..Macrophages appear to play a protective role in the development and/or repair of peritoneal adhesions...
  80. ncbi Cloning and structural analysis of the human c-kit gene
    G R Vandenbark
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Oncogene 7:1259-66. 1992
    ..These data will allow investigation into the control of KIT expression and the potential to identify mutations or altered expression of this gene in human disease...
  81. ncbi An unexpected effect of glucocorticoids on stimulation of c-fms proto-oncogene expression in choriocarcinoma cells that express little glucocorticoid receptor
    Setsuko K Chambers
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 190:974-85. 2004
    ..The purpose of this study was to determine the mechanism by which glucocorticoids stimulate c-fms proto-oncogene expression in JAR choriocarcinoma cells, which are reported to lack the glucocorticoid receptor...
  82. ncbi Fertility impairment and improved fetal survival induced by a tumor cell line in mice
    N Brosh
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Am J Reprod Immunol 26:47-51. 1991
    ..We consequently hypothesize that this tumor exerts its abortifacient effect not via its strong immunogenicity but via cytokines it secretes...
  83. ncbi Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinase
    H Kim
    Department of Cell Biology University of Alabama, Birmingham
    Oncogene 6:1085-7. 1991
    ..Heat stable tau was identified in cultured peripheral blood monocytes. This represents the first molecular characterization of tau in cells of non-neural origin...
  84. ncbi Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element
    Maryann B Flick
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06510 8040, USA
    J Cell Biochem 85:10-23. 2002
    ....
  85. ncbi NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells
    Yue Xie
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 291:1071-80. 2002
    ..Our studies suggest a strong mutual antagonism between the heat shock response and APR, which may influence the sensitivity and duration of inflammatory responses...
  86. pmc Biological activity of the receptor for macrophage colony-stimulating factor in the human endometrial cancer cell line, Ishikawa
    S Takeda
    Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Br J Cancer 73:615-9. 1996
    ..Using retroviral infections to introduce and express exogenous c-fms genes in Ishikawa cells we also demonstrate proliferation to be partially inhibited by a dominant negative, mutant c-..
  87. ncbi RAS and FMS mutations following cytotoxic therapy for childhood acute lymphoblastic leukaemia
    C Taylor
    Haematology Department, University of Wales College of Medicine, Health Park, Cardiff, UK
    Leukemia 9:466-70. 1995
    ..Continued follow-up of these patients may indicate a role for these mutations in the development of secondary malignancies...
  88. ncbi DNA repair in the MYC and FMS proto-oncogenes in ultraviolet light-irradiated human HL60 promyelocytic cells during differentiation
    A L Islas
    Department of Biological Sciences, Stanford University, California 94305 5020
    Cancer Res 55:336-41. 1995
    ....
  89. ncbi The proto-oncogene c-fms is overexpressed in endometrial cancer
    G S Leiserowitz
    Section of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905
    Gynecol Oncol 49:190-6. 1993
    ..Our study confirms the overexpression of c-fms in endometrial cancer and demonstrates a positive correlation between the steady-state mRNA levels of c-fms and other select adverse prognostic indicators...
  90. pmc Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP
    S Trouliaris
    , , Germany
    J Virol 69:6010-20. 1995
    ....
  91. ncbi All-trans retinoic acid induces monocyte growth factor receptor (c-fms) gene expression in HL-60 leukemia cells
    H C Hsu
    Laboratory of Clinical Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Leukemia 7:458-62. 1993
    ..Our results indicate that retinoic acid can induce features of both monocytic and granulocytic differentiation in HL-60 cells...
  92. ncbi Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodelling
    D A Hume
    Centre for Molecular and Cellular Biology, University of Queensland, Australia
    Br J Haematol 90:939-42. 1995
    ..The localization of c-fms expression was consistent with its restriction to macrophages, and with the location of those macrophages in sites of tissue turnover and extensive cell death...
  93. ncbi Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF
    Y Oghiso
    Division of Comparative Radiotoxicology, National Institute of Radiological Sciences, Chiba, Japan
    J Leukoc Biol 53:86-92. 1993
    ..These results suggest that two distinctly different suppressor cells developed under hemopoiesis of myelomonocytic lineage cells are regulated differentially by the two macrophage growth factors, M-CSF and GM-CSF...
  94. pmc Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
    ....
  95. ncbi Modulation of c-myc, c-myb, c-fos, c-sis and c-fms proto-oncogene expression and of CSF-1 transcripts and protein by phorbol diester in human malignant histiocytosis DEL cell line with 5q 35 break point
    J Gogusev
    Unite Inserm 90, Hospital Necker Enfants Malades, Paris, France
    Anticancer Res 13:1043-7. 1993
    ..Through this drug-induced modulation, the DEL cell line offers an additional model for studying some of the subtle interrelations existing between a growth factor (CSF-1) and its receptor (c-fms) in the monocyte/macrophage system...
  96. ncbi c-fms point mutations in acute myeloid leukemia: fact or fiction?
    F Springall
    Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Leukemia 7:978-85. 1993
    ..This study suggests that c-fms mutations at codons 301 and 969 are not important in the pathogenesis of AML in the vast majority of patients...
  97. ncbi A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages
    M Martin
    Lions Laboratory, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 150:4395-406. 1993
    ..This inducible, rapid switch of virtually the entire population provides a unique model for the molecular analysis of mechanisms involved in cell-fate determination...
  98. ncbi Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots
    D T Bowen
    Leukaemia Research Fund Preleukaemia Unit, University Hospital of Wales, Health Park, Cardiff UK
    Leukemia 7:1883-5. 1993
    ..Polymorphisms occur frequently in the KIT gene. Together with this study, a total of five have been described...
  99. ncbi Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids
    E Sapi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8040
    Oncogene 10:529-42. 1995
    ....
  100. ncbi Enhancement of J6-1 human leukemic cell proliferation by cell-cell contact: role of an M-CSF-like membrane-associated growth factor MAF-J6-1
    K F Wu
    Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin
    Leuk Res 18:843-9. 1994
    ..Taken together, our results suggest that the membrane-bound MAF-J6-1 promote J6-1 cell proliferation and cluster formation through a 'juxtacrine' mechanism...
  101. ncbi Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype
    J Woolford
    Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 55:965-77. 1988
    ..Using chimeric fms genes and site-directed mutagenesis, we have determined that the C-terminal modification present in v-fms is ..

Research Grants5

  1. PHARMACOLOGIC AND MOLECULAR CONTROL OF C-JUN IN LEUKEMIA
    MATTHEW SHERMAN; Fiscal Year: 1992
    ..Thus, it is hoped that these studies will provide certain insights into the regulation of early response gene expression and possibly lead to the design of novel approaches to overcome the block in the differentiation of leukemia cells...
  2. CSF-1 AND DRUG RESISTANCE IN REPRODUCTIVE CANCERS
    SETSUKO CHAMBERS; Fiscal Year: 1991
    ..Our long-term objectives would be to understand the molecular biology underlying platinum resistance in ovarian cancer and to develop long awaited therapeutics in this disease...
  3. CSF-1 RECEPTOR SIGNALLING AND G1 PROGRESSION
    Martine Roussel; Fiscal Year: 2001
    ..The identification of novel effector molecules should enable definition of regulatory networks that govern events late in G1 phase, including the commitment to enter S phase. ..
  4. Predicting Melanoma Response to BAY 43-9006/Chemotherapy
    Harriet Kluger; Fiscal Year: 2008
    ..We will assess individual markers as well as panels of markers. [unreadable] [unreadable]..
  5. Tyrosine Kinase Pathways in Autoimmune Arthritis.
    Ricardo Paniagua; Fiscal Year: 2008
    ....