Genomes and Genes
Summary: Family of genes originally isolated from the Susan McDonough strain of feline sarcoma virus (SARCOMA VIRUSES, FELINE). The proto-oncogene fms (c-fms) codes for the MCSF receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR). The oncogene fms (v-fms) codes for ONCOGENE PROTEIN GP140(V-FMS) which is a mutated form of the MCSF. The human c-fms gene is located between 5q33.2 and 5q33.3.
- Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genesYue Xie
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:4687-98. 2003..Mapping the structural domains involved in this process should permit further characterization of molecular mechanisms that mediate repression...
- Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expressionZhenqiang Yao
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 281:11846-55. 2006..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
- Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injuryChia Jen Siao
Department of Pharmacological Sciences, Program in Molecular and Cellular Pharmacology, University Medical Center at Stony Brook, Stony Brook, New York 11794 8651, USA
J Neurosci 23:3234-42. 2003..We suggest that an approach to attenuate microglia-mediated neuronal death in vivo might be to pharmacologically prevent microglial activation...
- Colony stimulating factor-1 expression in human gliomaR L Alterman
Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10461
Mol Chem Neuropathol 21:177-88. 1994..We conclude that coexpression of CSF-1 and its receptor in some human gliomas hints at a possible autocrine or paracrine growth stimulatory role for CSF-1; however, its function in the mammalian CNS remains to be elucidated...
- SGK1, a potential regulator of c-fms related breast cancer aggressivenessJacob Tangir
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, Connecticut, USA
Clin Exp Metastasis 21:477-83. 2004..This finding may have implications for potential therapeutic interventions aimed at decreasing the aggressiveness of breast cancer cells...
- Differential expression of protooncogenes in human germ cell tumors of the testisT Shuin
Department of Urology, Yokohama City University School of Medicine, Japan
Cancer 73:1721-7. 1994..It has been suggested that tumorigenesis of the germ cell tumor of the testis includes abnormal and developmentlike differentiation of primordial germ cells to several mature type tumors...
- Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversibleHiromi Tagoh
Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
EMBO J 23:4275-85. 2004..However, even at mature B cell stages, c-fms chromatin is still in a poised conformation and c-fms expression can be re-activated by conditional deletion of the transcription factor Pax5...
- Transcriptional regulation of the c-fms proto-oncogene mediated by granulocyte/macrophage colony-stimulating factor (GM-CSF) in murine cell linesG Helftenbein
Institut fur Virologie, Justus Liebig Universitat Giessen, Germany
Oncogene 12:931-5. 1996..Furthermore, a 2.1 kb genomic fragment containing the c-fms proximal promoter directs GM-CSF-inducible expression of a reporter gene, suggesting a regulation of c-fms gene expression on the transcriptional level...
- Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathyPeter Dickie
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Virology 322:69-81. 2004..However, the unique contribution of macrophage-specific Vpr expression in the development of glomerular disease was underscored by the induction of FGS in multiple murine lines bearing a c-fms/vpr transgene...
- CSF-1 deficiency in mice results in abnormal brain developmentM D Michaelson
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Development 122:2661-72. 1996..The effects of CSF-1 on cultured embryonic neural cells, the developmentally appropriate expression of CSF-1 and its receptor, and the neurological abnormalities in op/op mice suggest a role for CSF-1 in brain development...
- Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesisN Brownlow
Leukemia 22:649-52. 2008
- Oncogenic potential of the c-FMS proto-oncogene (CSF-1 receptor)Martine F Roussel
Dept of Genetics and Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
Cell Cycle 2:5-6. 2003
- Reassessment of the murine c-fms proto-oncogene sequenceN de Parseval
ICGM, INSERM U363, Hopital Cochin, Paris, France
Nucleic Acids Res 21:750. 1993
- Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongationX Yue
Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
Mol Cell Biol 13:3191-201. 1993..The results suggest that expression of the c-fms gene in macrophages is controlled by sequences in intron 2 that act by regulating transcription elongation...
- Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse developmentR J Arceci
Pediatric Hematology Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
Dev Biol 151:1-8. 1992..The patterns of CSF-1/c-fms mRNA and SF/c-kit mRNA expression are consistent with the hypothesis that these two ligand/receptor systems may act in a compensatory or synergistic manner during preimplantation development...
- Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic miceDmitry A Ovchinnikov
Institute for Molecular Bioscience, Bldg 80, University of Queensland, Brisbane, Queensland 4072, Australia
J Leukoc Biol 83:430-3. 2008..The new mouse line provides a useful tool for overexpression of transgenes in cells of the myeloid lineage, while simultaneously labeling them by ECFP expression...
- A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expressionS R Himes
Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
J Leukoc Biol 70:812-20. 2001..Removal of FIRE abolished reporter gene expression, revealing a suppressive activity in the remaining intronic sequences. Hence, FIRE is shown to be a key regulatory element in the fms gene...
- Clone and expression of mutant M-CSF and its receptor from human leukemic cell line J6-1Ge Li
National Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, PR China
Leuk Res 26:377-82. 2002..COS-7 cells transfected with MAF-J6-1-R show obvious protein tyrosine kinase (PTK) activity. Our present work shows that MAF-J6-1 and its receptor are mutations of M-CSF and its receptor...
- Microglia derived from aging mice exhibit an altered inflammatory profileAmanda Sierra
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
Glia 55:412-24. 2007..Gender differences were not overall observed across the treatments (age, LPS). The low but sustained production of pro-inflammatory cytokines by aging microglia may have a profound impact in the brain aging process...
- A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms geneHanna Krysinska
University of Leeds, Leeds Institute of Molecular Medicine, St James s University Hospital, Wellcome Trust Brenner Building, Leeds LS9 7TF, United Kingdom
Mol Cell Biol 27:878-87. 2007..The two-step mechanism of developmental gene activation that we describe here may be utilized to regulate gene activity in a variety of developmental pathways...
- PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitorsR P DeKoter
Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
EMBO J 17:4456-68. 1998..1 into mutant progenitors restores responsiveness to myeloid-specific cytokines and development of mature granulocytes and macrophages. Thus PU.1 controls myelopoiesis by regulating both proliferation and differentiation pathways...
- Interleukin-3 and granulocyte-macrophage colony-stimulating factor inhibits tumor necrosis factor (TNF)-alpha-induced osteoclast differentiation by down-regulation of expression of TNF receptors 1 and 2S D Yogesha
National Center for Cell Science, University of Pune Campus, Ganeshkhind Rd, Pune 411 007, India
J Biol Chem 280:11759-69. 2005..In summary, we provide the first evidence that IL-3 and GM-CSF block TNF-alpha-induced osteoclast differentiation by down-regulation of mRNA and surface expression of TNFR1 and TNFR2...
- Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1beta complexAkiko Satou
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo 060 0812, Japan
FEBS Lett 572:211-5. 2004..Of the two promoters, pE1 and pE2, in the c-fms gene, pE1 promoter activity was found to be activated in an E-box-dependent manner...
- Heterogeneity among cells that express osteoclast-associated genes in developing boneR Jemtland
Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston 02114, USA
Endocrinology 139:340-9. 1998..Alternatively, type IV collagenase-positive and TRAP/c-fms-positive cells may represent distinct subpopulations of cells of the osteoclast lineage...
- Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumorsSimon Chu
Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
Gynecol Oncol 108:182-90. 2008..A recent case report of a patient with advanced recurrent GCT responding to the tyrosine kinase inhibitor, imatinib mesylate prompted us to explore a role for these therapies in GCT...
- Preliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexedPietro Bertino
DISCAFF Department and DFBC Center, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
Thorax 62:690-5. 2007..A study was undertaken to assess whether imatinib alone or combined with chemotherapeutic agents may be effective for treating mesothelioma...
- Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosisFaisel M Abu-Duhier
Academic Unit of Haematology, Division of Genomic Medicine, Royal Hallamshire Hospital, Sheffield, UK
Br J Haematol 120:464-70. 2003..Intronic primers were used to amplify the entire coding region of both the C-KIT and C-FMS genes, and selected regions of the FLT3 gene...
- Osteoclast molecular phenotyping by random cDNA sequencingD Sakai
Molecular Biology Program, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
Bone 17:111-9. 1995..I. = 1.2-4.9%), c-fms and ribosomal protein L18 (95% C.I. = 0.8-4.3%), and cathepsin-OC2, cyclophilin, delta-aminolevulinate synthetase, 16S mitochondrial rRNA, and two novel gene sequences (95% C.I. = 0.5-3.6%)...
- The first intron of human c-fms proto-oncogene contains a processed pseudogene (RPL7P) for ribosomal protein L7E Sapi
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510
Genomics 22:641-5. 1994..We also showed that despite the fact that the 5' flanking region of the RPL7 sequence contains a potential TATA box upstream of an intact open reading frame, this pseudogene (RPL7P) is not actively transcribed...
- [Deletional polymorphism of the 11th intron of the human c-fms gene: allele frequency in certain Russian populations and possible functional significance]T N Kuznetsova
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia
Genetika 40:102-12. 2004..In case of trichmoniasis, the frequency of rare allele was 2.4 times lower, and in case of acute bronchitis it was 2.1 times higher than in the control sample...
- Molecular epidemiology of vancomycin-resistant Enterococcus faecium: a prospective, multicenter study in South American hospitalsDiana Panesso
Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogota, Colombia
J Clin Microbiol 48:1562-9. 2010..All VREfm isolates were evaluated for the presence of 16 putative virulence genes (14 fms genes, the esp gene of E. faecium [espEfm], and the hyl gene of E...
- Analysis of clonality and antibiotic resistance among early clinical isolates of Enterococcus faecium in the United StatesJessica R Galloway-Peña
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA
J Infect Dis 200:1566-73. 2009..The Enterococcus faecium genogroup, referred to as clonal complex 17 (CC17), seems to possess multiple determinants that increase its ability to survive and cause disease in nosocomial environments...
- Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cellsA Rambaldi
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
J Clin Invest 81:1030-5. 1988..These results demonstrate that leukemic myeloblasts from a subset of patients with AML express transcripts for both the CSF-1 and CSF-1 receptor genes, often in the same leukemic cells in vitro...
- The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophagesStewart R Himes
CRC for Chronic Inflammatory Disease, Institute for Molecular Biosciences, Queensland Biosciences Precinct, Bldg 80, Services Rd, University of Queensland, Brisbane, Queensland 4072, Australia
Oncogene 24:5278-86. 2005..The runx1 and c-fms genes showed an identical pattern of expression in mature macrophages...
- c-FMS mutational analysis in acute myeloid leukaemiaFaisel M Abu-Duhier
Br J Haematol 123:749-50. 2003
- Simple chemicals can induce maturation and apoptosis of dendritic cellsH Manome
Department of Dermatology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
Immunology 98:481-90. 1999....
- Identification of receptor genes in renal cell carcinoma associated with angiogenesis by differential hybridization techniqueA Takahashi
Department of Urology, Sapporo Medical University School of Medicine, W 16, Sapporo, 060 8543, Japan
Biochem Biophys Res Commun 257:855-9. 1999..FGFR-4 mRNA was expressed in three of the four cell lines. These results suggest that KDR, FLT-1, PlGF and TIE1 mRNAs are present in the mesenchymal cells of RCC, while VEGF and FGFR-4 genes are expressed in RCC cells themselves in vivo...
- Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response elementMaryann B Flick
Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06510 8040, USA
J Cell Biochem 85:10-23. 2002....
- Functional expressions of fms and M-CSF during trophoectodermal differentiation of human embryonal carcinoma cellsN Suzuki
Department of Pathology, Keio University School of Medicine, Tokyo, Japan
Placenta 20:203-11. 1999..G3 cells are well suited to serve as an experimental model of human early embryogenesis and of placental differentiation...
- NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cellsYue Xie
Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
Biochem Biophys Res Commun 291:1071-80. 2002..Our studies suggest a strong mutual antagonism between the heat shock response and APR, which may influence the sensitivity and duration of inflammatory responses...
- A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signallingMaddalena Cross
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050, Australia
Biochem J 380:243-53. 2004..The phosphorylation of p110 myosin XVIIIA by CSF-1 may alter its cellular localization or target its association with other proteins...
- Modulation of c-myc, c-myb, c-fos, c-sis and c-fms proto-oncogene expression and of CSF-1 transcripts and protein by phorbol diester in human malignant histiocytosis DEL cell line with 5q 35 break pointJ Gogusev
Unite Inserm 90, Hospital Necker Enfants Malades, Paris, France
Anticancer Res 13:1043-7. 1993..Through this drug-induced modulation, the DEL cell line offers an additional model for studying some of the subtle interrelations existing between a growth factor (CSF-1) and its receptor (c-fms) in the monocyte/macrophage system...
- An unexpected effect of glucocorticoids on stimulation of c-fms proto-oncogene expression in choriocarcinoma cells that express little glucocorticoid receptorSetsuko K Chambers
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 190:974-85. 2004..The purpose of this study was to determine the mechanism by which glucocorticoids stimulate c-fms proto-oncogene expression in JAR choriocarcinoma cells, which are reported to lack the glucocorticoid receptor...
- E2a/Pbx1 oncogene inhibits terminal differentiation but not myeloid potential of pro-T cellsR P Bourette
Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, Villeurbanne Cedex, France
Oncogene 26:234-47. 2007..Finally, additional experiments suggested that PU.1 and eight twenty-one transcriptional regulators might be implicated in the mechanisms of oncogenesis by E2a/Pbx1...
- Lack of TP53 and FMS gene mutations in children with myelodysplastic syndromeBiljana Jekic
Institute of Biology and Human Genetics, School of Medicine, 26 Visegradska Str, 11000 Belgrade, Serbia and Montenegro
Cancer Genet Cytogenet 166:163-5. 2006..Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults...
- [Detection of homologous oncogene sequences in the genome of Plasmodium falciparum]C Macary
, La Tronche
C R Acad Sci III 312:37-42. 1991..The oncogene study will allow an understanding of the biology of the parasite and particularly the host-parasite relationships which allow P. falciparum to develop, keeping the established harmony between the parasite and his host...
- Development of peritoneal adhesions in macrophage depleted miceSandra H Burnett
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA
J Surg Res 131:296-301. 2006..Macrophages appear to play a protective role in the development and/or repair of peritoneal adhesions...
- The relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinomaDong Hua Yang
Department of Gastroenterology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China
Hepatobiliary Pancreat Dis Int 3:86-9. 2004..This study is to investigate the relationship between point mutation and abnormal expression of c-fms oncogene in hepatocellular carcinoma (HCC) and to clarify the mechanism of HCC...
- cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer modelHarriet M Kluger
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Lab Invest 84:320-31. 2004..These genes provide a basis for further studies of metastatic progression and local invasiveness, and can be evaluated as therapeutic targets...
- Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expressionBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
Mol Cell Biol 24:1453-63. 2004....
- The role of CSF-1 in normal physiology of mammary gland and breast cancer: an updateEva Sapi
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
Exp Biol Med (Maywood) 229:1-11. 2004....
- Tyrosine kinases in AML: where do they fit in?Robert L Ilaria
Leuk Res 28:217-8. 2004
- Epigenetic consequences of AML1-ETO action at the human c-FMS locusGeorge A Follows
Molecular Medicine Unit, University of Leeds, St James s University Hospital, Leeds LS9 7TF, UK
EMBO J 22:2798-809. 2003..Our experiments provide for the first time a direct insight into the chromatin structure of an AML1-ETO-bound target gene...
- Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in miceJia Li
Department of Development and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Genesis 44:328-35. 2006..This conditional allele will prove extremely valuable to study the spatial and temporal roles of CSF-1R...
- Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogeneL B Giebel
Department of Medical Genetics, University of Wisconsin, Madison 53706
Oncogene 7:2207-17. 1992..Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome...
- Isolation and chromosomal localization of a novel FMS-like tyrosine kinase geneO Rosnet
U 119 INSERM, Marseille, France
Genomics 9:380-5. 1991..We have localized the human FLT3 gene to chromosome 13, band q12, and its mouse homolog to chromosome 5, region G...
- Differential introduction and repair of psoralen photoadducts to DNA in specific human genesA L Islas
Department of Biological Sciences, Stanford University, California 94305 5020
Cancer Res 51:2867-73. 1991..The implications for DNA repair of chromatin structure and active transcription are discussed in relation to our results...
- A dominant suppressive mutation in a cellular gene restores the nontransformed phenotype to v-fms-transformed mink cellsJ Kato
Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
Oncogene 6:687-93. 1991....
- [Acute myeloblastic leukemia associated with 46, XY, del(5)(q22)]Y Motohashi
Third Department of Internal Medicine, Nihon University School of Medicine
Rinsho Ketsueki 31:979-83. 1990..He was diagnosed de novo AML, since he had not been received the therapy with potential mutagenic and carcinogenic agents and had not been exposed the irradiation on his works...
- c-fms expression in acute leukemias with complex phenotypesH Torres
Unité 119 de l INSERM, Institut Paoli Calmettes, Marseille, France
Leukemia 4:673-7. 1990..Thus expression of the c-fms/CSF-1 receptor may not be exclusively a marker for myeloid proliferations...
- Oncogenes and tumor suppressor genesG Klein
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
Acta Oncol 27:427-37. 1988..DNA binding proteins, presumably involved in DNA replication may drive cell division after constitutive activation by retroviral insertion, chromosomal translocation or gene amplification (example: the myc-family)...
- Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotypeJ Woolford
Department of Cell Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Cell 55:965-77. 1988..Using chimeric fms genes and site-directed mutagenesis, we have determined that the C-terminal modification present in v-fms is ..
- DNA repair in the MYC and FMS proto-oncogenes in ultraviolet light-irradiated human HL60 promyelocytic cells during differentiationA L Islas
Department of Biological Sciences, Stanford University, California 94305 5020
Cancer Res 55:336-41. 1995....
- [Parallel loss of c-FMS and GM-CSF genes in myeloid leukemias with 5q-chromosome]K Tanaka
Department of Hematology, Hiroshima University
Rinsho Ketsueki 32:931-7. 1991..These findings suggest that c-FMS oncogene and GM-CSF gene locating in the critical region on chromosome 5 seem to have an important role in the process of leukemogenesis...
- Evidence for tau expression in cells of monocyte lineage and its in vitro phosphorylation by v-fms kinaseH Kim
Department of Cell Biology University of Alabama, Birmingham
Oncogene 6:1085-7. 1991..Heat stable tau was identified in cultured peripheral blood monocytes. This represents the first molecular characterization of tau in cells of non-neural origin...
- Amplification of the c-myc proto-oncogene in human chondrosarcomaJ S Castresana
Department of Tumor Pathology, Karolinska Hospital, Stockholm, Sweden
Diagn Mol Pathol 1:235-8. 1992..The clinical significance of this gene amplification remains to be established...
- Multilineage phenotypes of interleukin-3-dependent progenitor cellsA M Ford
Leukaemia Research Fund Centre, Chester Beatty Laboratories, London, England
Blood 79:1962-71. 1992....
- Cloning and structural analysis of the human c-kit geneG R Vandenbark
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Oncogene 7:1259-66. 1992..These data will allow investigation into the control of KIT expression and the potential to identify mutations or altered expression of this gene in human disease...
- [Activation of protooncogenes by point mutations in hematological malignancies]T Goto
Third Department of Internal Medicine, Faculty of Medicine, University of Kyushu
Nippon Rinsho 50:1335-40. 1992..Furthermore, mutations in the 3' border of the exon 1 of c-myc are frequent, and may play an additional role in pathogenesis of Burkitt lymphoma...
- Alteration of the c-fms gene in a blood sample from a Thorotrast individualF R Collart
Biological and Medical Research Division, Argonne National Laboratory, IL 60439
Health Phys 63:27-32. 1992....
- Synergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factorsD Metcalf
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
Proc Natl Acad Sci U S A 89:2819-23. 1992..This phenomenon of synergistic suppression may have relevance for the future clinical use of combinations of CSFs, because a potentially similar suppression is also observable with some normal macrophage progenitor cells...
- Gene mutations in myelodysplasiaA Jacobs
University of Wales College of Medicine, Cardiff
Leuk Res 16:47-50. 1992..The data suggest the inability of mutant ras or fms genes alone to produce observable preleukaemic changes but that subjects with these mutations may be predisposed to ..
- Fertility impairment and improved fetal survival induced by a tumor cell line in miceN Brosh
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
Am J Reprod Immunol 26:47-51. 1991..We consequently hypothesize that this tumor exerts its abortifacient effect not via its strong immunogenicity but via cytokines it secretes...
- Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAPS Trouliaris
, , Germany
J Virol 69:6010-20. 1995....
- Detection of c-fms protooncogene in early mouse embryos by whole mount in situ hybridization indicates roles for macrophages in tissue remodellingD A Hume
Centre for Molecular and Cellular Biology, University of Queensland, Australia
Br J Haematol 90:939-42. 1995..The localization of c-fms expression was consistent with its restriction to macrophages, and with the location of those macrophages in sites of tissue turnover and extensive cell death...
- Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSFY Oghiso
Division of Comparative Radiotoxicology, National Institute of Radiological Sciences, Chiba, Japan
J Leukoc Biol 53:86-92. 1993..These results suggest that two distinctly different suppressor cells developed under hemopoiesis of myelomonocytic lineage cells are regulated differentially by the two macrophage growth factors, M-CSF and GM-CSF...
- The proto-oncogene c-fms is overexpressed in endometrial cancerG S Leiserowitz
Section of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905
Gynecol Oncol 49:190-6. 1993..Our study confirms the overexpression of c-fms in endometrial cancer and demonstrates a positive correlation between the steady-state mRNA levels of c-fms and other select adverse prognostic indicators...
- Biological activity of the receptor for macrophage colony-stimulating factor in the human endometrial cancer cell line, IshikawaS Takeda
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Br J Cancer 73:615-9. 1996..Using retroviral infections to introduce and express exogenous c-fms genes in Ishikawa cells we also demonstrate proliferation to be partially inhibited by a dominant negative, mutant c-..
- Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genesC Andre
Laboratoire de Biochimie et Biologie Moleculaire, UPR41 CNRS, 2, Rennes, France
Genomics 39:216-26. 1997..We have conducted a detailed structural analysis of the two loci containing the KIT and FMS genes. The sequence of the approximately 90-kb KIT locus reveals the position and size of the 21 introns and of the 5' ..
- The promoter of macrophage colony-stimulating factor receptor is active in astrocytesM Tkachuk
PRPG, Hofmann La Roche AG, Basel, Switzerland
Neurosci Lett 225:121-5. 1997..We hypothesize that M-CSF released by astrocytes, upon stimulation by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF alpha) or interleukin-1 (IL-1), regulates the expression of its own receptor...
- Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibodyM B Flick
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
Oncogene 14:2553-61. 1997..This data represents the first direct evidence of in vivo phosphorylation of CSF-1R in human breast carcinomas...
- Genetic aberrations in the development and subsequent progression of myelodysplastic syndromeS Misawa
Third Department of Medicine, Kyoto Prefectural University of Medicine, Japan
Leukemia 11:533-5. 1997..However, patients who showed an NRAS mutation had a shorter survival time once the mutation emerged, similar to that of patients with a TP53 mutation...
- [Molecular abnormalities and clonality in myelodysplastic syndromes]P Fenaux
Service des Maladies du Sang, CHU de Lille, France
Pathol Biol (Paris) 45:556-60. 1997..This opens up the promising possibility that transplantation of autologous multipotent stem cells may be an effective therapeutic approach...
- RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-upR A Padua
Department of Hematology, University of Wales College of Medicine, Cardiff, UK
Leukemia 12:887-92. 1998..005). This study shows that oncogene mutation, indicative of genetic instability, is associated with disease progression and poor survival in MDS...
- All-trans retinoic acid induces monocyte growth factor receptor (c-fms) gene expression in HL-60 leukemia cellsH C Hsu
Laboratory of Clinical Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
Leukemia 7:458-62. 1993..Our results indicate that retinoic acid can induce features of both monocytic and granulocytic differentiation in HL-60 cells...
- Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cellsA Roulston
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
J Virol 67:5235-46. 1993....
- A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineagesM Martin
Lions Laboratory, Royal Melbourne Hospital, Victoria, Australia
J Immunol 150:4395-406. 1993..This inducible, rapid switch of virtually the entire population provides a unique model for the molecular analysis of mechanisms involved in cell-fate determination...
- Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spotsD T Bowen
Leukaemia Research Fund Preleukaemia Unit, University Hospital of Wales, Health Park, Cardiff UK
Leukemia 7:1883-5. 1993..Polymorphisms occur frequently in the KIT gene. Together with this study, a total of five have been described...
- Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoidsE Sapi
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510 8040
Oncogene 10:529-42. 1995....
- Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic mediT Inaba
3rd Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
J Clin Invest 95:1133-9. 1995..These results indicate that multiple growth factors and cytokines may play a role in the phenotypic transformation of medial smooth muscle cells to intimal smooth muscle cells in atherosclerotic lesions by altering c-fms expression...
- RAS and FMS mutations following cytotoxic therapy for childhood acute lymphoblastic leukaemiaC Taylor
Haematology Department, University of Wales College of Medicine, Health Park, Cardiff, UK
Leukemia 9:466-70. 1995..Continued follow-up of these patients may indicate a role for these mutations in the development of secondary malignancies...
- The relationship of the in vivo cell cycle characteristics and treatment outcome in acute myelogenous leukemia to the expression of the FMS and MYC proto-oncogenesH D Preisler
Rush Cancer Institute, Chicago, IL 60612
Leuk Lymphoma 14:273-8. 1994..No significant relationship between the expression levels of these two genes and the cell cycle characteristics of leukemia cells in vivo were detected...
- Enhancement of J6-1 human leukemic cell proliferation by cell-cell contact: role of an M-CSF-like membrane-associated growth factor MAF-J6-1K F Wu
Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin
Leuk Res 18:843-9. 1994..Taken together, our results suggest that the membrane-bound MAF-J6-1 promote J6-1 cell proliferation and cluster formation through a 'juxtacrine' mechanism...
- c-fms point mutations in acute myeloid leukemia: fact or fiction?F Springall
Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Leukemia 7:978-85. 1993..This study suggests that c-fms mutations at codons 301 and 969 are not important in the pathogenesis of AML in the vast majority of patients...
- Biological consequences of a point mutation at codon 969 of the FMS geneH McGlynn
School of Biomedical Sciences, University of Ulster at Coleraine, N Ireland, UK
Leuk Res 22:365-72. 1998..These data indicate that there is a biological role for FMS codon 969 phenylalanine mutation which results in transformation of FDC-P1 cells...
- Late-pregnancy factor induces fetal toleranceRicardo Paniagua; Fiscal Year: 2007....
- Predicting Melanoma Response to BAY 43-9006/ChemotherapyHarriet Kluger; Fiscal Year: 2007..We will assess individual markers as well as panels of markers. ..
- CSF-1 RECEPTOR SIGNALLING AND G1 PROGRESSIONMartine Roussel; Fiscal Year: 2001..The identification of novel effector molecules should enable definition of regulatory networks that govern events late in G1 phase, including the commitment to enter S phase. ..
- FMS TRANSFORMATION/CSF-1 RECEPTOR SIGNAL TRANSDUCTIONMartine Roussel; Fiscal Year: 1993..Foci of transformed cells will be isolated, and the relevant portions of their FMS genes will be directly sequenced after amplification of the target cassette by polymerase chain reaction...