Genomes and Genes
Summary: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Publications311 found, 100 shown here
- Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyI Bernard Weinstein
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Nat Clin Pract Oncol 3:448-57. 2006..e. the 'Achilles' heel,' in specific cancers. Finally, we discuss the use of molecular targeted agents in combination with other anticancer agents as a strategy to optimize therapy and prevent disease recurrence...
- Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cellsChristine Mayr
Howard Hughes Medical Institute, USA
Cell 138:673-84. 2009In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene...
- The control of the metabolic switch in cancers by oncogenes and tumor suppressor genesArnold J Levine
Institute for Advanced Study, Princeton, NJ 08540, USA
Science 330:1340-4. 2010..switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways...
- microRNAs as oncogenes and tumor suppressorsBaohong Zhang
Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
Dev Biol 302:1-12. 2007..In addition, some miRNAs may function as oncogenes or tumor suppressors...
- Cancer genes and the pathways they controlBert Vogelstein
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
Nat Med 10:789-99. 2004..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
- A microRNA polycistron as a potential human oncogeneLin He
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nature 435:828-33. 2005..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
- MicroRNAs as oncogenes and tumor suppressorsChang Zheng Chen
Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, Calif, USA
N Engl J Med 353:1768-71. 2005
- Oncogenes and cancerCarlo M Croce
Department of Molecular Virology, Immunology, and Medical Genetics and the Human Cancer Genetics Program, Ohio State University Medical Center, Columbus, OH 43210, USA
N Engl J Med 358:502-11. 2008
- MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenesYunqing Li
Departments of Microbiology, Neurology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
Cancer Res 69:7569-76. 2009..They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch. The results also suggest that miR-34a could serve as a potential therapeutic agent for brain tumors...
- DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisJirina Bartkova
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
Nature 434:864-70. 2005..Similar checkpoint responses were induced in cultured cells upon expression of different oncogenes that deregulate DNA replication...
- Oncogenic pathway signatures in human cancers as a guide to targeted therapiesAndrea H Bild
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
Nature 439:353-7. 2006..Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics...
- Cancer. Addiction to oncogenes--the Achilles heal of cancerI Bernard Weinstein
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
Science 297:63-4. 2002
- A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomasKartik M Mani
Department of Biomedical Informatics DBMI, Columbia University, New York, NY 10032, USA
Mol Syst Biol 4:169. 2008..The method consistently ranked the known gene in the top 20 (0.3%), outperforming conventional approaches in 3 of 4 cases...
- Control of autophagy by oncogenes and tumor suppressor genesM C Maiuri
INSERM, U848, Apoptosis Cancer and Immunity, F 94805 Villejuif, France
Cell Death Differ 16:87-93. 2009Multiple oncogenes (in particular phosphatidylinositol 3-kinase, PI3K; activated Akt1; antiapoptotic proteins from the Bcl-2 family) inhibit autophagy...
- Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancerKazimierz O Wrzeszczynski
Bioinformatics and Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
PLoS ONE 6:e28503. 2011..interested in copy number variation as our base genomic property in the prediction of tumor suppressors and oncogenes in the altered ovarian tumor...
- Oncogene addictionI Bernard Weinstein
Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
Cancer Res 68:3077-80; discussion 3080. 2008..e., the "Achilles heel") in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction...
- Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFPaul T C Wan
Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Cell 116:855-67. 2004..The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism...
- A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenesO A Kent
The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Oncogene 25:6188-96. 2006The known classes of genes that function as tumor suppressors and oncogenes have recently been expanded to include the microRNA (miRNA) family of regulatory molecules...
- Gene amplification in cancerDonna G Albertson
Cancer Research Institute and Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Trends Genet 22:447-55. 2006..Clinically, amplification has prognostic and diagnostic usefulness, and is a mechanism of acquired drug resistance...
- Molecular classification of cancer: class discovery and class prediction by gene expression monitoringT R Golub
Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
Science 286:531-7. 1999....
- An oncogene-induced DNA damage model for cancer developmentThanos D Halazonetis
Department of Molecular Biology and Department of Biochemistry, University of Geneva, CH 1205 Geneva, Switzerland
Science 319:1352-5. 2008..Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of DNA replication forks, which in turn leads to formation of DNA DSBs...
- High-throughput oncogene mutation profiling in human cancerRoman K Thomas
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
Nat Genet 39:347-51. 2007..This approach established robust mutation distributions spanning 17 cancer types. Of 17 oncogenes analyzed, we found 14 to be mutated at least once, and 298 (30%) samples carried at least one mutation...
- Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationChristine Mayr
Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 315:1576-9. 2007..Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells...
- Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancerRaffaella Di Micco
IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
Nat Cell Biol 13:292-302. 2011..These results indicate that heterochromatin induced by oncogenic stress restrains DDR and suggest that the use of chromatin-modifying drugs in cancer therapies may benefit from the study of chromatin and DDR status of tumours...
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenesA Ullrich
Nature 313:756-61. 1985..There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products...
- Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneW J Muller
Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
Cell 54:105-15. 1988..stochastic occurrence of solitary mammary tumors in transgenic mice bearing the MMTV/c-myc or the MMTV/v-Ha-ras oncogenes, transgenic mice uniformly expressing the MMTV/c-neu gene develop mammary adenocarcinomas that involve the ..
- Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approachLars Zender
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Cell 125:1253-67. 2006..analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon...
- Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in miceDinorah Friedmann-Morvinski
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Science 338:1080-4. 2012....
- Proinvasion metastasis drivers in early-stage melanoma are oncogenesKenneth L Scott
Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Cell 20:92-103. 2011..Furthermore, we show that one such gene, ACP5, confers spontaneous metastasis in vivo, engages a key pathway governing metastasis, and is prognostic in human primary melanomas...
- Chromosome aberrations in solid tumorsDonna G Albertson
Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0808, USA
Nat Genet 34:369-76. 2003....
- A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumorsP Mathijs Voorhoeve
Division of Tumour Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Cell 124:1169-81. 2006..In a screen for miRNAs that cooperate with oncogenes in cellular transformation, we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis ..
- SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cellsSi Chen
School of Medicine, Nankai University, Tianjin, China
PLoS ONE 7:e36326. 2012..In addition, obviously higher expression of oncogenes c-MYC, WNT1, WNT2, and NOTCH1 was detected in side population (SP) cells than in non-side population (NSP) cells ..
- Oncogenes and tumor suppressor genesEva Y H P Lee
Department of Biological Chemistry and Department of Developmental and Cell Biology, University of California, Irvine, California 92697 4037, USA
Cold Spring Harb Perspect Biol 2:a003236. 2010Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes...
- Molecular cytogenetic analysis of 11 new breast cancer cell linesF Forozan
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4470, USA
Br J Cancer 81:1328-34. 1999..One-third of these loci affected breast cancer oncogenes, whose amplifications were validated with specific probes: 17q12 (two cell lines with ERBB2 amplifications), ..
- Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell linesZ Q Yang
Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan
Cancer Res 60:4735-9. 2000..Because amplified regions often harbor oncogenes and/or other tumor-associated genes, and because 9p23-24 amplification had been reported in various other types ..
- Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3M Chesi
Genetics Department, National Cancer Institute, Bethesda, Maryland 20889 5105, USA
Nat Genet 16:260-4. 1997Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours. In multiple myeloma (MM), translocations to the IgH locus have been reported at an incidence of 20-60%...
- Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomasA L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Leukemia 23:574-80. 2009b>Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors...
- Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaLevi A Garraway
Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Nature 436:117-22. 2005..Together, these data suggest that MITF represents a distinct class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific cancer development and tumour progression.
- Multiple stress signals activate mutant p53 in vivoYoung Ah Suh
Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 71:7168-75. 2011..In this report, we examined the role of oncogenes, DNA damage, and reactive oxygen species, signals that stabilize wild-type p53, on the stabilization of mutant ..
- miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cellsGiorgio Zauli
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Clin Cancer Res 17:2712-24. 2011To elucidate new molecular mechanisms able to downregulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective.
- High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenesEdwin Choy
Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 118:2905-14. 2012..The identification of new genes that are mutated in osteosarcomas is critical to developing a better understanding of the molecular pathogenesis of this disease and discovering new targets for therapeutic development...
- Polarity proteins in migration and invasionS Etienne-Manneville
Cell Polarity and Migration Group, Institut Pasteur and CNRS URA 2582, Paris Cedex 15, France
Oncogene 27:6970-80. 2008..The aim of this review is to highlight the molecular relationship between the control of cell polarity and the regulation of cell motility during oncogenesis...
- Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathwaysS Song
McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 95:2290-5. 1998..Thus pRb and/or pRb-like proteins likely mediate both p53-dependent and p53-independent responses to radiation...
- Traps to catch unwary oncogenesA O Hueber
Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK
Trends Genet 14:364-7. 1998..We discuss such synergy with respect to the cooperating oncogenes MYC, RAS and BCL2.
- MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity?P Mathijs Voorhoeve
Cancer and Stem Cell Biology Program, Duke NUS Graduate Medical School, 8 College Road, Singapore
Biochim Biophys Acta 1805:72-86. 2010..of tumor origin and behavior, they are causally linked to the emergence and development of cancer by acting as oncogenes or tumor suppressors...
- In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AMLAnmaar M Abdul-Nabi
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 5:e12464. 2010Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation...
- Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressorsBruno K Robbs
Division of Cellular Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil
Mol Cell Biol 28:7168-81. 2008..These results suggest that the NFAT1 gene acts as a tumor suppressor gene and the NFAT2 short isoform acts gene as an oncogene, supporting different roles for the two transcription factors in tumor development...
- Oncogenes in melanomaDavid Polsky
Department of Dermatology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
Oncogene 22:3087-91. 2003..We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.
- Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancerEija H Mahlamäki
Laboratory of Cancer Genetics, Tampere University Hospital and University of Tampere, Tampere, Finland
Genes Chromosomes Cancer 35:353-8. 2002..These results illustrate that amplification of genes from the 8q, 11q, 17q, and 20q chromosome arms is common in pancreatic cancer...
- The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescenceLixin Hong
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
Cancer Res 70:8547-57. 2010In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed...
- Modeling liver cancer using zebrafish: a comparative oncogenomics approachSiew Hong Lam
Department of Biological Sciences, National University of Singapore, Singapore
Cell Cycle 5:573-7. 2006..In addition, our comparative oncogenomic work provides a general framework for comparing and validating microarray data of zebrafish model with human cancer, thus adding confidence of using the zebrafish to model human cancers...
- Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancerScott A Tomlins
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nature 448:595-9. 2007..Identification of distinct classes of ETS gene rearrangements demonstrates that dormant oncogenes can be activated in prostate cancer by juxtaposition to tissue-specific or ubiquitously active genomic loci...
- Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemiaKaren Keeshan
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Cell 10:401-11. 2006..Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha...
- Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogeneK H Klempnauer
Cell 31:453-63. 1982..Comparisons between the sequences of v-myb and c-myb indicate that transduction of c-myb to form v-myb probably resulted from an initial DNA rearrangement and the subsequent use of a spliced RNA as an intermediate...
- Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenesCathy B Moelans
Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
Mod Pathol 23:1029-39. 2010Several oncogenes and tumor-suppressor genes have been shown to be implicated in the development, progression and response to therapy of invasive breast cancer...
- Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinasesYihua Sun
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Clin Oncol 28:4616-20. 2010..To determine the proportion of lung adenocarcinomas from East Asian never-smokers who harbor known oncogenic driver mutations...
- Cancer-associated IDH mutations: biomarker and therapeutic opportunitiesK E Yen
Molecular Oncology, Agios Pharmaceuticals, Cambridge, MA 02139, USA
Oncogene 29:6409-17. 2010..Several hypotheses implicating the elevated levels of D-2HG and tumorigenesis, and the therapeutic potential of targeting mutant IDH enzymes will be discussed...
- Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virusM D Waterfield
Nature 304:35-9. 1983..This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors...
- The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13T Boehm
Medical Research Council Laboratory of Molecular Biology, Cambridge United Kingdom
Proc Natl Acad Sci U S A 88:4367-71. 1991..The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.
- Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawalRocio Sotillo
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 464:436-40. 2010..This has led to the search for compounds that specifically target and inhibit oncogenes as anticancer agents...
- The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCLWeimin Ci
Division of Hematology Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Blood 113:5536-48. 2009..The specific BCL6 inhibitor retro-inverso BCL6 peptidomimetic inhibitor-induced expression of BCL2 and other oncogenes, consistent with direct repression effects by BCL6...
- p53: guardian of the genome and policeman of the oncogenesAlejo Efeyan
Tumor Suppression Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
Cell Cycle 6:1006-10. 2007..consists in sensing and reacting to DNA damage through the ATM/ATR and Chk1/Chk2 kinases, and "policeman of the oncogenes" that, correspondingly, consists in responding to oncogenic signaling through the p53-stabilizing protein ARF...
- Many roads lead to oncogene-induced senescenceS Courtois-Cox
Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 2115, USA
Oncogene 27:2801-9. 2008..This review will focus on integrating current models and will highlight data that provide new insight into the signals that function to suppress human tumor development...
- Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancerK A Kwei
Department of Pathology, Stanford University, Stanford, CA 94305 5176, USA
Oncogene 27:3635-40. 2008Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13...
- Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcomaMaaike van Dartel
Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Cancer Genet Cytogenet 139:91-6. 2002..p12 has been found in 13%-29% of high-grade osteosarcomas, suggesting the presence of an oncogene or oncogenes that may contribute to their development...
- Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applicationsCynthia Osborne
University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8852, USA
Oncologist 9:361-77. 2004..b>Oncogenes refer to those genes whose alterations cause gain-of-function effects, while tumor suppressor genes cause loss-..
- DAPk protein family and cancerDevrim Gozuacik
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Autophagy 2:74-9. 2006..autophagic cell death signals in response to various cellular stresses including the misregulated expression of oncogenes in pre-malignant cells...
- Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemiaSeverine Landais
Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
Cancer Res 67:5699-707. 2007....
- Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factorR F Doolittle
Science 221:275-7. 1983..The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth...
- Spi-1 is a putative oncogene in virally induced murine erythroleukaemiasF Moreau-Gachelin
INSERM U 248, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
Nature 331:277-80. 1988..insertional mutagenesis has been proposed as an efficient mechanism to turn on or to increase the expression of oncogenes in several avian or mammal models...
- MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumorsLong R Jiao
Hepato Pancreato Biliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, London, UK
PLoS ONE 7:e32068. 2012..The mechanistic consequences of miRNA dysregulation were further evaluated...
- Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinductionMartin Jechlinger
Program in Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Genes Dev 23:1677-88. 2009..system to analyze the responses of primary mouse mammary epithelial cells to the induction and deinduction of oncogenes. Mammary cells derived from normal virgin mice, or from tritransgenic mice (TetO-MYC;TetO-Kras(G12D);MMTV-rtTA) ..
- Microarray-based oncogenic pathway profiling in advanced serous papillary ovarian carcinomaXuan Bich Trinh
Translational Cancer Research Unit, St Augustinus GZA Hospitals, Antwerp, Belgium
PLoS ONE 6:e22469. 2011..The identification of specific targets for treatment of ovarian cancer patients remains a challenge. The objective of this study is the analysis of oncogenic pathways in ovarian cancer and their relation with clinical outcome...
- Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypesAndreas Klein
Charite Universitatsmedizin Berlin, Campus Charite Mitte, Institut fur Biochemie, Monbijoustrasse 2, Berlin, Germany
Cancer Genet Cytogenet 200:79-99. 2010..Despite such karyotypic evidence for causality, three to six synergistic mutations, termed oncogenes, are generally thought to cause cancer...
- A sparse regulatory network of copy-number driven gene expression reveals putative breast cancer oncogenesYinyin Yuan
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
IEEE/ACM Trans Comput Biol Bioinform 9:947-54. 2012Copy number aberrations are recognized to be important in cancer as they may localize to regions harboring oncogenes or tumor suppressors. Such genomic alterations mediate phenotypic changes through their impact on expression...
- NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinasesM M Reddy
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Leukemia 25:281-9. 2011Transformation by tyrosine kinase oncogenes (TKOs) in myeloid malignancies, including BCR-ABL in chronic myeloid leukemia, FLT3ITD in acute myeloid leukemia or JAK2V617F in myeloproliferative neoplasms, is associated with increased ..
- Estrogens and human papilloma virus oncogenes regulate human ether-à-go-go-1 potassium channel expressionLorenza Díaz
Departamento de Biologia de la Reproduccion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cancer Res 69:3300-7. 2009..We studied hEag1 gene expression and its regulation by estradiol, antiestrogens, and human papillomavirus (HPV) oncogenes (E6/E7)...
- The DNA damage signaling pathway is a critical mediator of oncogene-induced senescenceFrédérick A Mallette
Departement de Biochimie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
Genes Dev 21:43-8. 2007..Intriguingly, bypassing oncogene-induced senescence by inactivation of p53 and Rb did not eliminate the accumulation of oncogene-induced DNA damage foci (ODDI), suggesting a mechanism that may limit transformation in immortalized cells...
- ASPP: a new family of oncogenes and tumour suppressor genesA Sullivan
Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
Br J Cancer 96:196-200. 2007..Thus, the ASPP family of proteins helps to determine how cells choose to die and may therefore be a novel target for cancer therapy...
- Oncogenic alterations of metabolismC V Dang
Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Trends Biochem Sci 24:68-72. 1999....
- Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinomaShayna E A Street
Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Cancer Res 67:5454-60. 2007..This data suggests that perforin may mediate some suppression of epithelial carcinogenesis by intervening early in the tumor development process...
- Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesisArturo Sala
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, United Kingdom
Adv Cancer Res 105:115-32. 2009..We will discuss how and under what circumstances oncogenes and epigenetic factors modify CLU expression, with important consequences for mammalian tumorigenesis.
- Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcomaXin Yan Lu
Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
Mol Cancer Res 6:937-46. 2008..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma...
- Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistenceAndrea Luísa Suárez
Department of Microbiology, University of Colorado Denver School of Medicine, 12800 E 19th Avenue, Aurora, CO 80045, USA
J Virol 85:6293-308. 2011..Furthermore, we identified two viral oncogenes, v-cyclin and v-Bcl2, that are critical to EC survival and that modify EC proliferation and survival during ..
- Mapping of the p53 and mdm-2 interaction domainsJ Chen
Department of Molecular Biology, Princeton University, New Jersey 08544 1014
Mol Cell Biol 13:4107-14. 1993..This region contains the transactivation domain of p53, suggesting that mdm-2 may inhibit p53 function by disrupting its interaction with the general transcription machinery...
- New insights into oncogene addiction foundKen Garber
J Natl Cancer Inst 99:264-5, 269. 2007
- A role for HPV16 E5 in cervical carcinogenesisJohn P Maufort
Department of Oncology and the McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Cancer Res 70:2924-31. 2010..HPV16 encodes three oncogenes: E5, E6, and E7...
- Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblastsL M Matrisian
EMBO J 4:1435-40. 1985..is also rapidly induced by the polypeptide growth factor epidermal growth factor, providing a new link between oncogenes and growth factors...
- Oncogene-induced senescence: the bright and dark side of the responseVassilis G Gorgoulis
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece
Curr Opin Cell Biol 22:816-27. 2010In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since then large leaps in understanding this phenomenon have been achieved...
- Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?Kuan Teh Jeang
Kuan Teh Jeang, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892, USA
Oncotarget 1:453-6. 2010..Here we discuss the possibility that early ATL cells are Tax-oncogene-addicted while late ATL cells are oncogenic microRNA (oncomiR) - addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached...
- The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic functionBodo Brueckner
Divisions of Epigenetics and Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Cancer Res 67:1419-23. 2007..Our results thus identify let-7a-3 as an epigenetically regulated miRNA gene with oncogenic function and suggest that aberrant miRNA gene methylation might contribute to the human cancer epigenome...
- High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancerSuet F Chin
Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Genome Biol 8:R215. 2007..To date, most genome-wide array comparative genomic hybridization studies have used tumor panels of relatively large tumor size and high Nottingham Prognostic Index (NPI) that are not as representative of breast cancer demographics...
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsJirina Bartkova
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
Nature 444:633-7. 2006..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
- PIK3CA is implicated as an oncogene in ovarian cancerL Shayesteh
UCSF Cancer Center, University of California, San Francisco 941430 0808, USA
Nat Genet 21:99-102. 1999..Our observations suggest PIK3CA is an oncogene that has an important role in ovarian cancer...
- TORgeting oncogene addiction for cancer therapyAndrew Y Choo
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Cell 9:77-9. 2006..In the January issue of Nature Medicine, Thomas et al. identify the loss of VHL tumor suppressor gene as a potential determining factor in tumor sensitivity to rapamycin...
- Seeding and propagation of untransformed mouse mammary cells in the lungKatrina Podsypanina
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Science 321:1841-4. 2008..Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors...
- Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytesM Nees
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
J Virol 75:4283-96. 2001..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
- Oncogenes and tumour suppressors take on centrosomesKenji Fukasawa
Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Nat Rev Cancer 7:911-24. 2007..How these proteins control centrosome duplication and function, and how their mutational activation and/or inactivation results in numeral and functional centrosome abnormalities, is discussed in this Review...
- Targeting miR-205 in breast cancerHailong Wu
Southern Illinois University School of Medicine, Department of Medical Microbiology, Immunology and Cell Biology, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
Expert Opin Ther Targets 13:1439-48. 2009..malignancies and suggests a causal role of microRNAs in neoplasia, presumably because microRNAs can function as oncogenes or tumor suppressors...
- Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?Dean W Felsher
Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Cancer Res 68:3081-6; discussion 3086. 2008Cancer is a multistep process whereby genetic events that result in the activation of proto-oncogenes or the inactivation of tumor suppressor genes usurp physiologic programs mandating relentless proliferation and growth...
- Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenesRumi Sasaki
Virology Division, National Cancer Center Research Institute, Tokyo, Japan
Carcinogenesis 30:423-31. 2009..This first in vitro model system faithfully recapitulating the development of EOCs using normal human OSE cells should greatly facilitate further studies of EOCs...
- Oncogene cooperation in glioma genesisWEI contact ZHANG; Fiscal Year: 2010Cancer development and progression involve activation of multiple oncogenes and inactivation of multiple tumor suppressor genes...
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
- GENETIC ANALYSIS OF POLARITYRuth Steward; Fiscal Year: 2009..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
- Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy & ChemopreventionRuth Lupu; Fiscal Year: 2007....
- Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy & ChemopreventionRuth Lupu; Fiscal Year: 2009....
- The Role of Cul4A in Genome Stability and Cancer DevelopmentLiang You; Fiscal Year: 2010..This model may be used to study the role that Cul4A plays in mesothelioma carcinogenesis, and may also be potentially useful for further drug discovery, e.g., to screen for molecules that inhibiting Cul4A-mediated p21 degradation. ..
- MicroRNAs and chromosome 22q in the colonAnil Rustgi; Fiscal Year: 2009..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
- S6 PHOSPHORYLATION AND TYROSINE PROTEIN KINASESJAMES MALLER; Fiscal Year: 1993The protein products of a number of retroviral oncogenes and growth factor receptors are protein tyrosine kinases...
- MicroRNAs and chromosome 22q in the colonAnil K Rustgi; Fiscal Year: 2010..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
- MicroRNAs and chromosome 22q in the colonAnil Rustgi; Fiscal Year: 2009..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
- STRUCTURE AND FUNCTION OF C-ABL PROTO-ONCOGENEJean Wang; Fiscal Year: 1992..c-abl proteins contain a tyrosine kinase domain which is essential to the transforming function of c-abl derived oncogenes. The ubiquitous expression of the c-abl gene suggests that it may serve a function common to all cells...
- Novel prostate cancer oncogenes identified by transposon mutagenesisPaul C Marker; Fiscal Year: 2010We have conducted a two-species pilot screen to discover new oncogenes and tumor suppressor genes that can drive prostate cancer initiation and/or progression in mice and humans...
- Converting an Oncogene to an Apoptotic Factor by Manipulating Signal SequencesCarol Lim; Fiscal Year: 2009..Our long-term, ultimate goal is to use localization controllable versions of Bcr-Abl (as gene therapy) for treatment of CML. ..
- Converting an Oncogene to an Apoptotic Factor by Manipulating Signal SequencesCarol S Lim; Fiscal Year: 2010..Our long-term, ultimate goal is to use localization controllable versions of Bcr-Abl (as gene therapy) for treatment of CML. ..
- MOLECULAR MECHANISMS IN METASTASISRuth Muschel; Fiscal Year: 1993..The tumors formed by each combination of oncogenes also grow at equivalent rates although those formed by H-ras plus ElA appear to be encapsulated...
- THERAPEUTIC MODULATION OF BREAST CANCER ONCOGENESChristopher Benz; Fiscal Year: 2002....