oncogenes

Summary

Summary: Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.

Top Publications

  1. ncbi Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
    I Bernard Weinstein
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nat Clin Pract Oncol 3:448-57. 2006
  2. pmc Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
    Christine Mayr
    Howard Hughes Medical Institute, USA
    Cell 138:673-84. 2009
  3. doi The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    Arnold J Levine
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Science 330:1340-4. 2010
  4. ncbi microRNAs as oncogenes and tumor suppressors
    Baohong Zhang
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
    Dev Biol 302:1-12. 2007
  5. ncbi Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
  6. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
  7. ncbi MicroRNAs as oncogenes and tumor suppressors
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    N Engl J Med 353:1768-71. 2005
  8. doi Oncogenes and cancer
    Carlo M Croce
    Department of Molecular Virology, Immunology, and Medical Genetics and the Human Cancer Genetics Program, Ohio State University Medical Center, Columbus, OH 43210, USA
    N Engl J Med 358:502-11. 2008
  9. pmc MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    Yunqing Li
    Departments of Microbiology, Neurology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Cancer Res 69:7569-76. 2009
  10. ncbi DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005

Research Grants

Detail Information

Publications312 found, 100 shown here

  1. ncbi Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
    I Bernard Weinstein
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Nat Clin Pract Oncol 3:448-57. 2006
    ..e. the 'Achilles' heel,' in specific cancers. Finally, we discuss the use of molecular targeted agents in combination with other anticancer agents as a strategy to optimize therapy and prevent disease recurrence...
  2. pmc Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
    Christine Mayr
    Howard Hughes Medical Institute, USA
    Cell 138:673-84. 2009
    In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein products of oncogenes are sometimes overexpressed without alteration of the proto-oncogene...
  3. doi The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    Arnold J Levine
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Science 330:1340-4. 2010
    ..switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways...
  4. ncbi microRNAs as oncogenes and tumor suppressors
    Baohong Zhang
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79409 1163, USA
    Dev Biol 302:1-12. 2007
    ..In addition, some miRNAs may function as oncogenes or tumor suppressors...
  5. ncbi Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
    ..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
  6. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
  7. ncbi MicroRNAs as oncogenes and tumor suppressors
    Chang Zheng Chen
    Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Institute for Cancer Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, Calif, USA
    N Engl J Med 353:1768-71. 2005
  8. doi Oncogenes and cancer
    Carlo M Croce
    Department of Molecular Virology, Immunology, and Medical Genetics and the Human Cancer Genetics Program, Ohio State University Medical Center, Columbus, OH 43210, USA
    N Engl J Med 358:502-11. 2008
  9. pmc MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    Yunqing Li
    Departments of Microbiology, Neurology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Cancer Res 69:7569-76. 2009
    ..They show that miR-34a suppresses brain tumor growth by targeting c-Met and Notch. The results also suggest that miR-34a could serve as a potential therapeutic agent for brain tumors...
  10. ncbi DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
    ..Similar checkpoint responses were induced in cultured cells upon expression of different oncogenes that deregulate DNA replication...
  11. ncbi Oncogenic pathway signatures in human cancers as a guide to targeted therapies
    Andrea H Bild
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Nature 439:353-7. 2006
    ..Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics...
  12. ncbi Cancer. Addiction to oncogenes--the Achilles heal of cancer
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Science 297:63-4. 2002
  13. pmc A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
    Kartik M Mani
    Department of Biomedical Informatics DBMI, Columbia University, New York, NY 10032, USA
    Mol Syst Biol 4:169. 2008
    ..The method consistently ranked the known gene in the top 20 (0.3%), outperforming conventional approaches in 3 of 4 cases...
  14. doi Control of autophagy by oncogenes and tumor suppressor genes
    M C Maiuri
    INSERM, U848, Apoptosis Cancer and Immunity, F 94805 Villejuif, France
    Cell Death Differ 16:87-93. 2009
    Multiple oncogenes (in particular phosphatidylinositol 3-kinase, PI3K; activated Akt1; antiapoptotic proteins from the Bcl-2 family) inhibit autophagy...
  15. pmc The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 21:1025-30. 2007
    ....
  16. pmc Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer
    Kazimierz O Wrzeszczynski
    Bioinformatics and Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS ONE 6:e28503. 2011
    ..interested in copy number variation as our base genomic property in the prediction of tumor suppressors and oncogenes in the altered ovarian tumor...
  17. ncbi Oncogene addiction
    I Bernard Weinstein
    Herbert Irving Comprehensive Cancer Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032 2704, USA
    Cancer Res 68:3077-80; discussion 3080. 2008
    ..e., the "Achilles heel") in specific cancers. Combination therapy may also be required to prevent the escape of cancers from a given state of oncogene addiction...
  18. ncbi Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    Paul T C Wan
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Cell 116:855-67. 2004
    ..The high activity mutants signal to ERK by directly phosphorylating MEK, whereas the impaired activity mutants stimulate MEK by activating endogenous C-RAF, possibly via an allosteric or transphosphorylation mechanism...
  19. ncbi A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes
    O A Kent
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncogene 25:6188-96. 2006
    The known classes of genes that function as tumor suppressors and oncogenes have recently been expanded to include the microRNA (miRNA) family of regulatory molecules...
  20. ncbi Gene amplification in cancer
    Donna G Albertson
    Cancer Research Institute and Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Genet 22:447-55. 2006
    ..Clinically, amplification has prognostic and diagnostic usefulness, and is a mechanism of acquired drug resistance...
  21. ncbi Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    T R Golub
    Whitehead Institute Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139, USA
    Science 286:531-7. 1999
    ....
  22. doi An oncogene-induced DNA damage model for cancer development
    Thanos D Halazonetis
    Department of Molecular Biology and Department of Biochemistry, University of Geneva, CH 1205 Geneva, Switzerland
    Science 319:1352-5. 2008
    ..Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of DNA replication forks, which in turn leads to formation of DNA DSBs...
  23. pmc Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    Christine Mayr
    Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 315:1576-9. 2007
    ..Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells...
  24. pmc Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
    Raffaella Di Micco
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Nat Cell Biol 13:292-302. 2011
    ..These results indicate that heterochromatin induced by oncogenic stress restrains DDR and suggest that the use of chromatin-modifying drugs in cancer therapies may benefit from the study of chromatin and DDR status of tumours...
  25. ncbi High-throughput oncogene mutation profiling in human cancer
    Roman K Thomas
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nat Genet 39:347-51. 2007
    ..This approach established robust mutation distributions spanning 17 cancer types. Of 17 oncogenes analyzed, we found 14 to be mutated at least once, and 298 (30%) samples carried at least one mutation...
  26. ncbi Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
    A Ullrich
    Nature 313:756-61. 1985
    ..There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products...
  27. ncbi Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    W J Muller
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
    Cell 54:105-15. 1988
    ..stochastic occurrence of solitary mammary tumors in transgenic mice bearing the MMTV/c-myc or the MMTV/v-Ha-ras oncogenes, transgenic mice uniformly expressing the MMTV/c-neu gene develop mammary adenocarcinomas that involve the ..
  28. pmc Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    Lars Zender
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 125:1253-67. 2006
    ..analyses delineated cIAP1, a known inhibitor of apoptosis, and Yap, a transcription factor, as candidate oncogenes in the amplicon...
  29. ncbi Chromosome aberrations in solid tumors
    Donna G Albertson
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0808, USA
    Nat Genet 34:369-76. 2003
    ....
  30. pmc Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
    Dinorah Friedmann-Morvinski
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 338:1080-4. 2012
    ....
  31. pmc SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells
    Si Chen
    School of Medicine, Nankai University, Tianjin, China
    PLoS ONE 7:e36326. 2012
    ..In addition, obviously higher expression of oncogenes c-MYC, WNT1, WNT2, and NOTCH1 was detected in side population (SP) cells than in non-side population (NSP) cells ..
  32. ncbi A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    P Mathijs Voorhoeve
    Division of Tumour Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cell 124:1169-81. 2006
    ..In a screen for miRNAs that cooperate with oncogenes in cellular transformation, we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis ..
  33. pmc Proinvasion metastasis drivers in early-stage melanoma are oncogenes
    Kenneth L Scott
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 20:92-103. 2011
    ..Furthermore, we show that one such gene, ACP5, confers spontaneous metastasis in vivo, engages a key pathway governing metastasis, and is prognostic in human primary melanomas...
  34. pmc Oncogenes and tumor suppressor genes
    Eva Y H P Lee
    Department of Biological Chemistry and Department of Developmental and Cell Biology, University of California, Irvine, California 92697 4037, USA
    Cold Spring Harb Perspect Biol 2:a003236. 2010
    Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes...
  35. ncbi Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines
    Z Q Yang
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Cancer Res 60:4735-9. 2000
    ..Because amplified regions often harbor oncogenes and/or other tumor-associated genes, and because 9p23-24 amplification had been reported in various other types ..
  36. pmc Molecular cytogenetic analysis of 11 new breast cancer cell lines
    F Forozan
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4470, USA
    Br J Cancer 81:1328-34. 1999
    ..One-third of these loci affected breast cancer oncogenes, whose amplifications were validated with specific probes: 17q12 (two cell lines with ERBB2 amplifications), ..
  37. ncbi Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    Levi A Garraway
    Department of Medical Oncology, and Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 436:117-22. 2005
    ..Together, these data suggest that MITF represents a distinct class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific cancer development and tumour progression.
  38. pmc Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    M Chesi
    Genetics Department, National Cancer Institute, Bethesda, Maryland 20889 5105, USA
    Nat Genet 16:260-4. 1997
    Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours. In multiple myeloma (MM), translocations to the IgH locus have been reported at an incidence of 20-60%...
  39. pmc Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
    A L Feldman
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 23:574-80. 2009
    b>Oncogenes involved in recurrent chromosomal translocations serve as diagnostic markers and therapeutic targets in hematopoietic tumors...
  40. pmc Multiple stress signals activate mutant p53 in vivo
    Young Ah Suh
    Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 71:7168-75. 2011
    ..In this report, we examined the role of oncogenes, DNA damage, and reactive oxygen species, signals that stabilize wild-type p53, on the stabilization of mutant ..
  41. doi miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells
    Giorgio Zauli
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Clin Cancer Res 17:2712-24. 2011
    To elucidate new molecular mechanisms able to downregulate the mRNA levels of key oncogenes, such as B-Myb and E2F1, in a therapeutic perspective.
  42. pmc High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes
    Edwin Choy
    Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer 118:2905-14. 2012
    ..The identification of new genes that are mutated in osteosarcomas is critical to developing a better understanding of the molecular pathogenesis of this disease and discovering new targets for therapeutic development...
  43. doi Polarity proteins in migration and invasion
    S Etienne-Manneville
    Cell Polarity and Migration Group, Institut Pasteur and CNRS URA 2582, Paris Cedex 15, France
    Oncogene 27:6970-80. 2008
    ..The aim of this review is to highlight the molecular relationship between the control of cell polarity and the regulation of cell motility during oncogenesis...
  44. pmc Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways
    S Song
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 95:2290-5. 1998
    ..Thus pRb and/or pRb-like proteins likely mediate both p53-dependent and p53-independent responses to radiation...
  45. pmc In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML
    Anmaar M Abdul-Nabi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e12464. 2010
    Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation...
  46. ncbi Traps to catch unwary oncogenes
    A O Hueber
    Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, London, UK
    Trends Genet 14:364-7. 1998
    ..We discuss such synergy with respect to the cooperating oncogenes MYC, RAS and BCL2.
  47. doi MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity?
    P Mathijs Voorhoeve
    Cancer and Stem Cell Biology Program, Duke NUS Graduate Medical School, 8 College Road, Singapore
    Biochim Biophys Acta 1805:72-86. 2010
    ..of tumor origin and behavior, they are causally linked to the emergence and development of cancer by acting as oncogenes or tumor suppressors...
  48. ncbi Oncogenes in melanoma
    David Polsky
    Department of Dermatology, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA
    Oncogene 22:3087-91. 2003
    ..We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.
  49. ncbi Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer
    Eija H Mahlamäki
    Laboratory of Cancer Genetics, Tampere University Hospital and University of Tampere, Tampere, Finland
    Genes Chromosomes Cancer 35:353-8. 2002
    ..These results illustrate that amplification of genes from the 8q, 11q, 17q, and 20q chromosome arms is common in pancreatic cancer...
  50. pmc Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors
    Bruno K Robbs
    Division of Cellular Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil
    Mol Cell Biol 28:7168-81. 2008
    ..These results suggest that the NFAT1 gene acts as a tumor suppressor gene and the NFAT2 short isoform acts gene as an oncogene, supporting different roles for the two transcription factors in tumor development...
  51. pmc The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL
    Weimin Ci
    Division of Hematology Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Blood 113:5536-48. 2009
    ..The specific BCL6 inhibitor retro-inverso BCL6 peptidomimetic inhibitor-induced expression of BCL2 and other oncogenes, consistent with direct repression effects by BCL6...
  52. ncbi Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
    Scott A Tomlins
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 448:595-9. 2007
    ..Identification of distinct classes of ETS gene rearrangements demonstrates that dormant oncogenes can be activated in prostate cancer by juxtaposition to tissue-specific or ubiquitously active genomic loci...
  53. pmc The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence
    Lixin Hong
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
    Cancer Res 70:8547-57. 2010
    In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed...
  54. pmc Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
    Yihua Sun
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Clin Oncol 28:4616-20. 2010
    ..To determine the proportion of lung adenocarcinomas from East Asian never-smokers who harbor known oncogenic driver mutations...
  55. pmc Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    Karen Keeshan
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Cell 10:401-11. 2006
    ..Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha...
  56. doi Cancer-associated IDH mutations: biomarker and therapeutic opportunities
    K E Yen
    Molecular Oncology, Agios Pharmaceuticals, Cambridge, MA 02139, USA
    Oncogene 29:6409-17. 2010
    ..Several hypotheses implicating the elevated levels of D-2HG and tumorigenesis, and the therapeutic potential of targeting mutant IDH enzymes will be discussed...
  57. ncbi Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
    M D Waterfield
    Nature 304:35-9. 1983
    ..This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors...
  58. pmc Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    Rocio Sotillo
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 464:436-40. 2010
    ..This has led to the search for compounds that specifically target and inhibit oncogenes as anticancer agents...
  59. pmc The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
    T Boehm
    Medical Research Council Laboratory of Molecular Biology, Cambridge United Kingdom
    Proc Natl Acad Sci U S A 88:4367-71. 1991
    ..The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.
  60. ncbi Modeling liver cancer using zebrafish: a comparative oncogenomics approach
    Siew Hong Lam
    Department of Biological Sciences, National University of Singapore, Singapore
    Cell Cycle 5:573-7. 2006
    ..In addition, our comparative oncogenomic work provides a general framework for comparing and validating microarray data of zebrafish model with human cancer, thus adding confidence of using the zebrafish to model human cancers...
  61. ncbi Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene
    K H Klempnauer
    Cell 31:453-63. 1982
    ..Comparisons between the sequences of v-myb and c-myb indicate that transduction of c-myb to form v-myb probably resulted from an initial DNA rearrangement and the subsequent use of a spliced RNA as an intermediate...
  62. doi Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes
    Cathy B Moelans
    Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mod Pathol 23:1029-39. 2010
    Several oncogenes and tumor-suppressor genes have been shown to be implicated in the development, progression and response to therapy of invasive breast cancer...
  63. ncbi p53: guardian of the genome and policeman of the oncogenes
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Cell Cycle 6:1006-10. 2007
    ..consists in sensing and reacting to DNA damage through the ATM/ATR and Chk1/Chk2 kinases, and "policeman of the oncogenes" that, correspondingly, consists in responding to oncogenic signaling through the p53-stabilizing protein ARF...
  64. ncbi Many roads lead to oncogene-induced senescence
    S Courtois-Cox
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 2115, USA
    Oncogene 27:2801-9. 2008
    ..This review will focus on integrating current models and will highlight data that provide new insight into the signals that function to suppress human tumor development...
  65. pmc Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer
    K A Kwei
    Department of Pathology, Stanford University, Stanford, CA 94305 5176, USA
    Oncogene 27:3635-40. 2008
    Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13...
  66. ncbi DAPk protein family and cancer
    Devrim Gozuacik
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Autophagy 2:74-9. 2006
    ..autophagic cell death signals in response to various cellular stresses including the misregulated expression of oncogenes in pre-malignant cells...
  67. ncbi Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma
    Maaike van Dartel
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cancer Genet Cytogenet 139:91-6. 2002
    ..p12 has been found in 13%-29% of high-grade osteosarcomas, suggesting the presence of an oncogene or oncogenes that may contribute to their development...
  68. ncbi Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications
    Cynthia Osborne
    University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8852, USA
    Oncologist 9:361-77. 2004
    ..b>Oncogenes refer to those genes whose alterations cause gain-of-function effects, while tumor suppressor genes cause loss-..
  69. ncbi Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia
    Severine Landais
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Cancer Res 67:5699-707. 2007
    ....
  70. ncbi Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
    R F Doolittle
    Science 221:275-7. 1983
    ..The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth...
  71. ncbi Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
    F Moreau-Gachelin
    INSERM U 248, Faculte de Medecine Lariboisiere Saint Louis, Paris, France
    Nature 331:277-80. 1988
    ..insertional mutagenesis has been proposed as an efficient mechanism to turn on or to increase the expression of oncogenes in several avian or mammal models...
  72. pmc Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151
    Takeshi Chiyomaru
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e43812. 2012
    ..This study suggests that genistein mediated suppression of oncogenic miRNAs can be an important dietary therapeutic strategy for the treatment of PCa...
  73. pmc Microarray-based oncogenic pathway profiling in advanced serous papillary ovarian carcinoma
    Xuan Bich Trinh
    Translational Cancer Research Unit, St Augustinus GZA Hospitals, Antwerp, Belgium
    PLoS ONE 6:e22469. 2011
    ..The identification of specific targets for treatment of ovarian cancer patients remains a challenge. The objective of this study is the analysis of oncogenic pathways in ovarian cancer and their relation with clinical outcome...
  74. pmc Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction
    Martin Jechlinger
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Genes Dev 23:1677-88. 2009
    ..system to analyze the responses of primary mouse mammary epithelial cells to the induction and deinduction of oncogenes. Mammary cells derived from normal virgin mice, or from tritransgenic mice (TetO-MYC;TetO-Kras(G12D);MMTV-rtTA) ..
  75. doi Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes
    Andreas Klein
    Charite Universitatsmedizin Berlin, Campus Charite Mitte, Institut fur Biochemie, Monbijoustrasse 2, Berlin, Germany
    Cancer Genet Cytogenet 200:79-99. 2010
    ..Despite such karyotypic evidence for causality, three to six synergistic mutations, termed oncogenes, are generally thought to cause cancer...
  76. ncbi A sparse regulatory network of copy-number driven gene expression reveals putative breast cancer oncogenes
    Yinyin Yuan
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom
    IEEE/ACM Trans Comput Biol Bioinform 9:947-54. 2012
    Copy number aberrations are recognized to be important in cancer as they may localize to regions harboring oncogenes or tumor suppressors. Such genomic alterations mediate phenotypic changes through their impact on expression...
  77. pmc MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors
    Long R Jiao
    Hepato Pancreato Biliary Surgical Unit, Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, London, UK
    PLoS ONE 7:e32068. 2012
    ..The mechanistic consequences of miRNA dysregulation were further evaluated...
  78. pmc The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    Frédérick A Mallette
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Genes Dev 21:43-8. 2007
    ..Intriguingly, bypassing oncogene-induced senescence by inactivation of p53 and Rb did not eliminate the accumulation of oncogene-induced DNA damage foci (ODDI), suggesting a mechanism that may limit transformation in immortalized cells...
  79. pmc ASPP: a new family of oncogenes and tumour suppressor genes
    A Sullivan
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Br J Cancer 96:196-200. 2007
    ..Thus, the ASPP family of proteins helps to determine how cells choose to die and may therefore be a novel target for cancer therapy...
  80. pmc NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases
    M M Reddy
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Leukemia 25:281-9. 2011
    Transformation by tyrosine kinase oncogenes (TKOs) in myeloid malignancies, including BCR-ABL in chronic myeloid leukemia, FLT3ITD in acute myeloid leukemia or JAK2V617F in myeloproliferative neoplasms, is associated with increased ..
  81. doi Estrogens and human papilloma virus oncogenes regulate human ether-à-go-go-1 potassium channel expression
    Lorenza Díaz
    Departamento de Biologia de la Reproduccion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
    Cancer Res 69:3300-7. 2009
    ..We studied hEag1 gene expression and its regulation by estradiol, antiestrogens, and human papillomavirus (HPV) oncogenes (E6/E7)...
  82. ncbi Oncogenic alterations of metabolism
    C V Dang
    Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Biochem Sci 24:68-72. 1999
    ....
  83. pmc Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis
    Arturo Sala
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, United Kingdom
    Adv Cancer Res 105:115-32. 2009
    ..We will discuss how and under what circumstances oncogenes and epigenetic factors modify CLU expression, with important consequences for mammalian tumorigenesis.
  84. pmc Mapping of the p53 and mdm-2 interaction domains
    J Chen
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Mol Cell Biol 13:4107-14. 1993
    ..This region contains the transactivation domain of p53, suggesting that mdm-2 may inhibit p53 function by disrupting its interaction with the general transcription machinery...
  85. pmc Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    Xin Yan Lu
    Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Mol Cancer Res 6:937-46. 2008
    ..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma...
  86. pmc Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence
    Andrea Luísa Suárez
    Department of Microbiology, University of Colorado Denver School of Medicine, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Virol 85:6293-308. 2011
    ..Furthermore, we identified two viral oncogenes, v-cyclin and v-Bcl2, that are critical to EC survival and that modify EC proliferation and survival during ..
  87. ncbi Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma
    Shayna E A Street
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 67:5454-60. 2007
    ..This data suggests that perforin may mediate some suppression of epithelial carcinogenesis by intervening early in the tumor development process...
  88. pmc A role for HPV16 E5 in cervical carcinogenesis
    John P Maufort
    Department of Oncology and the McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Cancer Res 70:2924-31. 2010
    ..HPV16 encodes three oncogenes: E5, E6, and E7...
  89. ncbi New insights into oncogene addiction found
    Ken Garber
    J Natl Cancer Inst 99:264-5, 269. 2007
  90. doi Oncogene-induced senescence: the bright and dark side of the response
    Vassilis G Gorgoulis
    Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece
    Curr Opin Cell Biol 22:816-27. 2010
    In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since then large leaps in understanding this phenomenon have been achieved...
  91. pmc Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts
    L M Matrisian
    EMBO J 4:1435-40. 1985
    ..is also rapidly induced by the polypeptide growth factor epidermal growth factor, providing a new link between oncogenes and growth factors...
  92. pmc Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
    Kuan Teh Jeang
    Kuan Teh Jeang, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncotarget 1:453-6. 2010
    ..Here we discuss the possibility that early ATL cells are Tax-oncogene-addicted while late ATL cells are oncogenic microRNA (oncomiR) - addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached...
  93. ncbi The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function
    Bodo Brueckner
    Divisions of Epigenetics and Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Res 67:1419-23. 2007
    ..Our results thus identify let-7a-3 as an epigenetically regulated miRNA gene with oncogenic function and suggest that aberrant miRNA gene methylation might contribute to the human cancer epigenome...
  94. ncbi Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006
    ..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
  95. ncbi TORgeting oncogene addiction for cancer therapy
    Andrew Y Choo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Cell 9:77-9. 2006
    ..In the January issue of Nature Medicine, Thomas et al. identify the loss of VHL tumor suppressor gene as a potential determining factor in tumor sensitivity to rapamycin...
  96. pmc High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
    Suet F Chin
    Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R215. 2007
    ..To date, most genome-wide array comparative genomic hybridization studies have used tumor panels of relatively large tumor size and high Nottingham Prognostic Index (NPI) that are not as representative of breast cancer demographics...
  97. ncbi PIK3CA is implicated as an oncogene in ovarian cancer
    L Shayesteh
    UCSF Cancer Center, University of California, San Francisco 941430 0808, USA
    Nat Genet 21:99-102. 1999
    ..Our observations suggest PIK3CA is an oncogene that has an important role in ovarian cancer...
  98. pmc Seeding and propagation of untransformed mouse mammary cells in the lung
    Katrina Podsypanina
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 321:1841-4. 2008
    ..Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors...
  99. ncbi Oncogenes and tumour suppressors take on centrosomes
    Kenji Fukasawa
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Nat Rev Cancer 7:911-24. 2007
    ..How these proteins control centrosome duplication and function, and how their mutational activation and/or inactivation results in numeral and functional centrosome abnormalities, is discussed in this Review...
  100. pmc Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes
    M Nees
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA
    J Virol 75:4283-96. 2001
    ..Thus, high-level expression of the HPV-16 E6 protein in differentiating keratinocytes directly alters expression of genes that influence host resistance to infection and immune function...
  101. ncbi Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?
    Dean W Felsher
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Cancer Res 68:3081-6; discussion 3086. 2008
    Cancer is a multistep process whereby genetic events that result in the activation of proto-oncogenes or the inactivation of tumor suppressor genes usurp physiologic programs mandating relentless proliferation and growth...

Research Grants138 found, 100 shown here

  1. Oncogene cooperation in glioma genesis
    WEI contact ZHANG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cancer development and progression involve activation of multiple oncogenes and inactivation of multiple tumor suppressor genes...
  2. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  3. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  4. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2011
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  5. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2010
    ....
  6. The Role of Cul4A in Genome Stability and Cancer Development
    Liang You; Fiscal Year: 2010
    ..This model may be used to study the role that Cul4A plays in mesothelioma carcinogenesis, and may also be potentially useful for further drug discovery, e.g., to screen for molecules that inhibiting Cul4A-mediated p21 degradation. ..
  7. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
  8. A Mouse Model for Human Gastrointestinal Stromal Tumor
    Peter Besmer; Fiscal Year: 2010
    ..Encouraged by our success to recapitulate familial GIST in mice we have produced mouse models for imatinib resistant GIST. We now will use these mice to evaluate new therapeutic strategies. ..
  9. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..
  10. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Our research will be useful in the development of novel treatments for the most aggressive forms of the childhood cancer neuroblastoma. ..
  11. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
  12. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..The miRNA-mediated repression of oncogenes or activation of tumor suppressor genes will be analyzed by luciferase assays using 3'UTR or 5'UTR ..
  13. BIOCHEMISTRY OF PRE-MRNA SPLICING
    Adrian R Krainer; Fiscal Year: 2010
    ..The proposed studies are aimed at understanding basic cellular mechanisms of gene expression, and may provide the basis for developing or improving diagnostic tools and therapeutic agents for these diseases. ..
  14. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..Considering the importance sex steroids in health and disease, we must have a better understanding of the mechanisms controlling the synthesis of steroid hormones. ..
  15. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..FOXP3 directly targets critical oncogenes HER2/ErbB2 and SKP2 and a tumor suppressor gene p21...
  16. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2012
    ..FOXP3 directly targets critical oncogenes HER2/ErbB2 and SKP2 and a tumor suppressor gene p21...
  17. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  18. Sex Chromosomes and Gender Disparity in HBV-Related Hepatocellular Carcinoma
    Yun Fai Chris Lau; Fiscal Year: 2010
    ..The proposed research is designed to elucidate the functions of this pair of homologous oncogene and tumor suppressor gene on HBx and male dominance in hepatocellular carcinoma development in hepatitis B virus infected populations. ..
  19. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2009
    ....
  20. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  21. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..Once available, these models will serve as novel platforms to identify new therapeutic targets for diseases caused by FUS/TLS mutations. ..
  22. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..blood-brain barrier (BBB) and blood-tumor barrier (BTB), penetrate xenografted, intracranial tumors, silence GBM oncogenes, and increase survival in mice...
  23. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2010
    ....
  24. CPG METHYLATION AND MUTATION
    Gerd P Pfeifer; Fiscal Year: 2013
    ..In parallel, we will study molecular pathways involving the Polycomb repression complex that might operate during tumor progression to promote hypermethylation of CpG islands in malignant tissue. ..
  25. Regulation of K-Ras by a Farnesyl-electrostatic Switch
    MARK REID PHILIPS; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Oncogenes are genes that cause cancer. K-Ras is the most important human oncogene...
  26. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2010
    ..We will also evaluate the predictive value of monitoring DNA circulating in plasma for mutations in target oncogenes using quantitative short oligonucleotide mass spectrometry...
  27. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..We will also evaluate the predictive value of monitoring DNA circulating in plasma for mutations in target oncogenes using quantitative short oligonucleotide mass spectrometry...
  28. Mechanism of BCL6-dependent stem cell maintenance in B cell lineage leukemia
    MARKUS MUSCHEN; Fiscal Year: 2010
    ..Since RI-BPI is currently going through the process of approval for use in clinical trials, we expect to be able to test the power of this approach in clinical trials by the end of the funding period. ..
  29. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2011
    ..Certain miRNAs can function as tumor suppressors and oncogenes. Thus, the current grant proposal to investigate the effect of A&I editing of miRNAs and siRNAs has ..
  30. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..Certain miRNAs can function as tumor suppressors and oncogenes. Thus, the current grant proposal to investigate the effect of A&I editing of miRNAs and siRNAs has ..
  31. Chromatin regulation by human SIRT7 in aging-associated cellular programs
    Katrin Chua; Fiscal Year: 2009
    ..Cellular senescence programs are triggered by telomere dysfunction, DNA damage, activated oncogenes, and other cellular stresses in the contexts of cancer and aging...
  32. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..abstract_text> ..
  33. Novel CTD inhibitors with synthetic lethality to oncogenic Ras for cancer therapy
    Bingliang Fang; Fiscal Year: 2013
    ..The goal of this proposal is to perform pre-clinical studies on their antitumor activities in lung cancer cells in vitro and in vivo that are required for future clinical trials. ..
  34. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2010
    ..We expect this research to lead to improved control of PTC with regard to early disease detection and better disease management and, thus, to enhance public health services. ..
  35. Recombination Repair Complex in Human Cells
    Richard Fishel; Fiscal Year: 2012
    ..provided by applicant): Genome instability is common to all tumors and is thought to drive the alteration of oncogenes, tumor suppressor genes as well as expression and epigenetic changes...
  36. Deregulated Wnt Signaling in Prostate Cancer
    Scott Houghtaling; Fiscal Year: 2009
    ..Nopage numbering necessary. Not to exceed 3publications;2 for predoctoral candidates.) K Check if Appendix is included PHS41R-1 Panp fi Fnrm Pane A ..
  37. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    Premature cell senescence induced by oncogenes and oxidative stress in vitro recapitulates many facets of replicative senescence and in vivo cellular aging...
  38. Validation of microRNAs as therapeutic targets in hematological malignancies
    Natarajan Muthusamy; Fiscal Year: 2013
    ..Therefore, we propose here to replace the low levels of natural microRNAs in leukemia cells with synthetic microRNAs as novel therapeutic approach to leukemia patients. ..
  39. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..we hypothesize that down-regulation of a set of microRNAs can inhibit tumor suppressor genes or activate oncogenes and re-expression of these miRNAs can reverse these effects thereby regulating prostate cancer progression...
  40. Alcohol and Iron Derived Oxidant Stress Impact Epigenetic Regulation
    JOHN contact WILKINSON IV; Fiscal Year: 2010
    ..Discovering such a mechanism would give us targets that may help prevent alcohol associated cancer formation. ..
  41. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ....
  42. GENETIC ANALYSIS OF POLARITY
    Ruth Steward; Fiscal Year: 2009
    ..We are aiming at developing a PCR approach to differentiate between the forms of PDCD2 found in normal bone marrow and blood, and the PDCD2 forms associated with leukemic cells. ..
  43. Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy & Chemoprevention
    Ruth Lupu; Fiscal Year: 2007
    ....
  44. Fatty Acid Synthase:Molecular Target for Breast Cancer Therapy & Chemoprevention
    Ruth Lupu; Fiscal Year: 2009
    ....
  45. Integrative Pathway Analysis of Eqigenomic/transcriptional Alteration in HNSCC
    Joseph Califano; Fiscal Year: 2009
    ..that genome-wide epigenetic unmasking and promoter hypomethylation frequently activate candidate proto-oncogenes and tumor specific cancer testes antigens in head and neck squamous cell carcinoma (HNSCC)...
  46. Integrative Pathway Analysis of Epigenomic/transcriptional Alteration in HNSCC
    Joseph A Califano; Fiscal Year: 2010
    ..that genome-wide epigenetic unmasking and promoter hypomethylation frequently activate candidate proto-oncogenes and tumor specific cancer testes antigens in head and neck squamous cell carcinoma (HNSCC)...
  47. Fatty Acid Synthase /Molecular Target /Breast Cancer The
    Ruth Lupu; Fiscal Year: 2005
    ....
  48. Fatty Acid Synthase: Characterization as a Novel Molecular Target for Breast Can*
    Ruth Lupu; Fiscal Year: 2006
    ....
  49. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
    ..Tumor suppressor mutations account for ~80% of all cancer mutations, but unlike activating mutations in oncogenes, cannot be targeted by drugs that inhibit a mutant gene product...
  50. REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Amato Giaccia; Fiscal Year: 1999
    ..and other have demonstrated an increase in chromosome instability either by the deregulated expression of proto-oncogenes such as ras that accelerates cell proliferation or through the loss of negative growth regulators such as p53 ..
  51. REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Amato Giaccia; Fiscal Year: 1999
    ..and other have demonstrated an increase in chromosome instability either by the deregulated expression of proto-oncogenes such as ras that accelerates cell proliferation or through the loss of negative growth regulators such as p53 ..
  52. MicroRNAs and chromosome 22q in the colon
    Anil Rustgi; Fiscal Year: 2009
    ..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
  53. NEU ONCOGENE IN HUMAN PROSTATE CANCER PROGRESSION
    Haiyen Zhau; Fiscal Year: 1993
    ....
  54. S6 PHOSPHORYLATION AND TYROSINE PROTEIN KINASES
    JAMES MALLER; Fiscal Year: 1993
    The protein products of a number of retroviral oncogenes and growth factor receptors are protein tyrosine kinases...
  55. MicroRNAs and chromosome 22q in the colon
    Anil Rustgi; Fiscal Year: 2009
    ..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
  56. MicroRNAs and chromosome 22q in the colon
    Anil K Rustgi; Fiscal Year: 2010
    ..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
  57. MicroRNAs and chromosome 22q in the colon
    Anil Rustgi; Fiscal Year: 2009
    ..instability pathway, involving alterations in key tumor suppressor genes (APC and p53, but also SMAD4) and oncogenes (especially Ras, but also EGFR, c-myc, B-Raf) and their downstream effectors...
  58. DETERMINANTS OF BC12 ONCOGENE TRANSLOCATIONS
    Theodore Krontiris; Fiscal Year: 1991
    ..The investigation of sequences which influence translocation of oncogenes may provide important insights into the mechanisms of genetic instability leading to lymphoma...
  59. DETERMINANTS OF BC12 ONCOGENE TRANSLOCATIONS
    Theodore Krontiris; Fiscal Year: 1992
    ..The investigation of sequences which influence translocation of oncogenes may provide important insights into the mechanisms of genetic instability leading to lymphoma...
  60. SALIVARY GLAND TRANSGENIC MOUSE MODEL
    ELISA DURBAN; Fiscal Year: 1990
    ..The long range goal of the applicant's laboratory is to establish the mechanisms whereby activated oncogenes with different functions may interfere with normal and abnormal salivary epithelial cell transitions...
  61. FUNCTION OF RAS ONCOGENE PROTEIN RELATED RAB PROTEINS
    Channing Der; Fiscal Year: 1991
    ....
  62. STRUCTURE AND FUNCTION OF C-ABL PROTO-ONCOGENE
    Jean Wang; Fiscal Year: 1991
    ..c-abl proteins contain a tyrosine kinase domain which is essential to the transforming function of c-abl derived oncogenes. The ubiquitous expression of the c-abl gene suggests that it may serve a function common to all cells...
  63. FUNCTION OF RAS ONCOGENE PROTEIN RELATED RAB PROTEINS
    Channing Der; Fiscal Year: 1992
    ....
  64. STRUCTURE AND FUNCTION OF C-ABL PROTO-ONCOGENE
    Jean Wang; Fiscal Year: 1992
    ..c-abl proteins contain a tyrosine kinase domain which is essential to the transforming function of c-abl derived oncogenes. The ubiquitous expression of the c-abl gene suggests that it may serve a function common to all cells...
  65. STRUCTURE AND FUNCTION OF C-ABL PROTO-ONCOGENE
    Jean Wang; Fiscal Year: 1990
    ..c-abl proteins contain a tyrosine kinase domain which is essential to the transforming function of c-abl derived oncogenes. The ubiquitous expression of the c-abl gene suggests that it may serve a function common to all cells...
  66. PROSTATE CANCER GENE THERAPY WITH RECOMBINANT VACCINES
    Martin Sanda; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Abstract) The hypothesis of the proposed studies is that modulation of prostatic oncogenes by androgen deprivation can augment the efficacy of oncogene-specific recombinant viral vaccine therapy of prostate ..
  67. Novel prostate cancer oncogenes identified by transposon mutagenesis
    Paul C Marker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We have conducted a two-species pilot screen to discover new oncogenes and tumor suppressor genes that can drive prostate cancer initiation and/or progression in mice and humans...
  68. PROSTATE CANCER GENE THERAPY WITH RECOMBINANT VACCINES
    Martin Sanda; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Abstract) The hypothesis of the proposed studies is that modulation of prostatic oncogenes by androgen deprivation can augment the efficacy of oncogene-specific recombinant viral vaccine therapy of prostate ..
  69. ANALYSIS OF CELLULAR ONCOGENES IN VIRUS-INDUCED TUMORS
    David Steffen; Fiscal Year: 1990
    ..The plan focuses on a family of genes which are targets for cancer causing mutations referred to as the proto-oncogenes. Using thymic lymphomas induced in rats by Moloney murine leukemia virus (MoMLV), new oncogenes will be ..
  70. ANALYSIS OF RAS ONCOGENE-ACTIVATED GENE EXPRESSION
    Michael Ostrowski; Fiscal Year: 1991
    Activated ras oncogenes are involved in the formation of many types of malignant tumors in animals, and have also been linked to human carcinogenesis...
  71. ANALYSIS OF RAS ONCOGENE-ACTIVATED GENE EXPRESSION
    Michael Ostrowski; Fiscal Year: 1992
    Activated ras oncogenes are involved in the formation of many types of malignant tumors in animals, and have also been linked to human carcinogenesis...
  72. ANALYSIS OF RAS ONCOGENE-ACTIVATED GENE EXPRESSION
    Michael Ostrowski; Fiscal Year: 1993
    Activated ras oncogenes are involved in the formation of many types of malignant tumors in animals, and have also been linked to human carcinogenesis...
  73. RAS ONCOGENE P21 FARNESYL TRANSFERASE--NOVEL ANTICANCE
    Said Sebti; Fiscal Year: 1992
    Ras oncogenes are the most frequently identified oncogenes in human cancers...