post translational protein processing

Summary

Summary: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.

Top Publications

  1. ncbi X-linked IAP is a direct inhibitor of cell-death proteases
    Q L Deveraux
    The Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA
    Nature 388:300-4. 1997
  2. ncbi Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
    Jesper V Olsen
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Cell 127:635-48. 2006
  3. ncbi Concepts in sumoylation: a decade on
    Ruth Geiss-Friedlander
    Department of Biochemie I, Faculty of Medicine, University of Goettingen, Humboldt Allee 23, 37073 Goettingen, Germany
    Nat Rev Mol Cell Biol 8:947-56. 2007
  4. ncbi Histone modifications in transcriptional regulation
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 12:142-8. 2002
  5. ncbi Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
    Nikolaj Blom
    Center for Biological Sequence Analysis, The Technical University of Denmark, Lyngby, Denmark
    Proteomics 4:1633-49. 2004
  6. ncbi A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    X Cao
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
    Science 293:115-20. 2001
  7. ncbi Global histone modification patterns predict risk of prostate cancer recurrence
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 435:1262-6. 2005
  8. ncbi Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
    H Saitoh
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 275:6252-8. 2000
  9. ncbi Proteomic analysis of post-translational modifications
    Matthias Mann
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK 5230 Denmark
    Nat Biotechnol 21:255-61. 2003
  10. ncbi Genome-wide patterns of histone modifications in yeast
    Catherine B Millar
    Department of Biological Chemistry, Geffen School of Medicine and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nat Rev Mol Cell Biol 7:657-66. 2006

Detail Information

Publications345 found, 100 shown here

  1. ncbi X-linked IAP is a direct inhibitor of cell-death proteases
    Q L Deveraux
    The Burnham Institute, Program on Apoptosis and Cell Death Research, La Jolla, California 92037, USA
    Nature 388:300-4. 1997
    ....
  2. ncbi Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
    Jesper V Olsen
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Cell 127:635-48. 2006
    ..The dynamic phosphoproteome provides a missing link in a global, integrative view of cellular regulation...
  3. ncbi Concepts in sumoylation: a decade on
    Ruth Geiss-Friedlander
    Department of Biochemie I, Faculty of Medicine, University of Goettingen, Humboldt Allee 23, 37073 Goettingen, Germany
    Nat Rev Mol Cell Biol 8:947-56. 2007
    ..At first glance, these effects have nothing in common; however, it seems that they all result from changes in the molecular interactions of the sumoylated proteins...
  4. ncbi Histone modifications in transcriptional regulation
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Genet Dev 12:142-8. 2002
    ..This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code...
  5. ncbi Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
    Nikolaj Blom
    Center for Biological Sequence Analysis, The Technical University of Denmark, Lyngby, Denmark
    Proteomics 4:1633-49. 2004
    ..The new server, NetPhosK, is made publicly available at the URL http://www.cbs.dtu.dk/services/NetPhosK/. The issues of underestimation, over-prediction and strategies for improving prediction specificity are also discussed...
  6. ncbi A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    X Cao
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
    Science 293:115-20. 2001
    ..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
  7. ncbi Global histone modification patterns predict risk of prostate cancer recurrence
    David B Seligson
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 435:1262-6. 2005
    ..Thus, widespread changes in specific histone modifications indicate previously undescribed molecular heterogeneity in prostate cancer and might underlie the broad range of clinical behaviour in cancer patients...
  8. ncbi Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
    H Saitoh
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 275:6252-8. 2000
    ..Together, these results support the concept of important distinctions between the SUMO-2/3 and SUMO-1 conjugation pathways and suggest a role for SUMO-2/3 in the cellular responses to environmental stress...
  9. ncbi Proteomic analysis of post-translational modifications
    Matthias Mann
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, Odense M, DK 5230 Denmark
    Nat Biotechnol 21:255-61. 2003
    ..Finally, stable isotope labeling strategies in combination with mass spectrometry have been applied successfully to study the dynamics of modifications...
  10. ncbi Genome-wide patterns of histone modifications in yeast
    Catherine B Millar
    Department of Biological Chemistry, Geffen School of Medicine and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nat Rev Mol Cell Biol 7:657-66. 2006
    ..Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression...
  11. ncbi Transcriptional regulation by the phosphorylation-dependent factor CREB
    B Mayr
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 2:599-609. 2001
    ..CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?..
  12. ncbi Protein posttranslational modifications: the chemistry of proteome diversifications
    Christopher T Walsh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Angew Chem Int Ed Engl 44:7342-72. 2005
    ..An understanding of the scope and pattern of the many posttranslational modifications in eukaryotic cells provides insight into the function and dynamics of proteome compositions...
  13. pmc Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications
    Lianna Johnson
    Life Science Core Curriculum, Department and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Nucleic Acids Res 32:6511-8. 2004
    ..The two histone H3 variants, H3.1 and H3.2, also differ in the abundance of silencing and activating marks confirming other studies showing that the replication-independent histone H3 is enriched in active chromatin...
  14. pmc Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
    Lijin Feng
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0322, USA
    Mol Cell Biol 25:5389-95. 2005
    ....
  15. pmc Global analysis of protein palmitoylation in yeast
    Amy F Roth
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Cell 125:1003-13. 2006
    ....
  16. ncbi Biosynthesis and mode of action of lantibiotics
    Champak Chatterjee
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA
    Chem Rev 105:633-84. 2005
  17. ncbi How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
    Sean D Taverna
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nat Struct Mol Biol 14:1025-40. 2007
    ..Changes in these interactions may have far-reaching implications for human biology and disease, notably cancer...
  18. ncbi Pervasive combinatorial modification of histone H3 in human cells
    Benjamin A Garcia
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Nat Methods 4:487-9. 2007
    ....
  19. ncbi A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    B De Strooper
    Neuronal Cell Biology and Gene Transfer Laboratory, Flanders Institute for Biotechnology VIB4, Center for Human Genetics, KU Leuven, Belgium
    Nature 398:518-22. 1999
    ..Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling...
  20. ncbi Identification of novel histone post-translational modifications by peptide mass fingerprinting
    Liwen Zhang
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    Chromosoma 112:77-86. 2003
    ..Consistent with the role of histone H3 lysine 79 methylation in the formation of silent chromatin structure, histone H4 lysine 59 is essential for transcriptional silencing at the yeast silent mating loci and telomeres...
  21. ncbi InsPecT: identification of posttranslationally modified peptides from tandem mass spectra
    Stephen Tanner
    Department of Bioengineering and Computer Science Department, APM 3832, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0114, USA
    Anal Chem 77:4626-39. 2005
    ..The tool was used to identify a number of novel modifications in different data sets, including many phosphopeptides in data provided by Alliance for Cellular Signaling that were missed by other tools...
  22. ncbi The age of crosstalk: phosphorylation, ubiquitination, and beyond
    Tony Hunter
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 28:730-8. 2007
    ..Particularly prominent are the multiple connections between phosphorylation and ubiquitination, which act either positively or negatively in both directions to regulate these processes...
  23. ncbi Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
    Min Gyu Lee
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 318:447-50. 2007
    ..Our results suggest a concerted mechanism for transcriptional activation in which cycles of H3K4 methylation by MLL2/3 are linked with the demethylation of H3K27 through UTX...
  24. ncbi c-Jun and p53 activity is modulated by SUMO-1 modification
    S Muller
    Unite de Recombinaison et Expression Genetique, INSERM Unité 163, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 275:13321-9. 2000
    ..Taken together, these data provide a first link between the SUMO-1 conjugation pathway and the regulation of transcription factors...
  25. ncbi Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    T Tabata
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 76:89-102. 1994
    ..We propose that the cell-cell communication mediated by hedgehog links the special properties of compartment borders with specification of the proximodistal axis in imaginal development...
  26. ncbi Protein palmitoylation by a family of DHHC protein S-acyltransferases
    David A Mitchell
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 47:1118-27. 2006
    ..This review presents the genetic and biochemical evidence for the PAT activity of DHHC proteins and discusses the mechanism of protein-mediated palmitoylation...
  27. ncbi A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
    N A Thornberry
    Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065
    Nature 356:768-74. 1992
    ..Selective inhibition of the enzyme in human blood monocytes blocks production of mature IL-1 beta, indicating that it is a potential therapeutic target...
  28. ncbi LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
    W Zhang
    Section on Lymphocyte Signaling, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5430, USA
    Immunity 9:239-46. 1998
    ..LAT is central to T cell activation and is a novel linker molecule shown to require targeting to membrane microdomains for signaling...
  29. ncbi Protein degradation and protection against misfolded or damaged proteins
    Alfred L Goldberg
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 426:895-9. 2003
    ..A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded...
  30. ncbi Expression patterns and post-translational modifications associated with mammalian histone H3 variants
    Sandra B Hake
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 281:559-68. 2006
    ..1 and H3.2 in mammalian cells should not be treated as equivalent proteins...
  31. pmc Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    Nat Rev Neurosci 8:948-59. 2007
    ....
  32. ncbi Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1
    Anne Rufiange
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec CHUQ, Quebec, Canada
    Mol Cell 27:393-405. 2007
    ..Taken together, our data underline the dynamic nature of replication-independent nucleosome assembly/disassembly, specify a link to transcription, and implicate Asf1 and H3 K56 acetylation...
  33. pmc O-GLYCBASE version 4.0: a revised database of O-glycosylated proteins
    R Gupta
    Center for Biological Sequence Analysis, The Technical University of Denmark, DK 2800 Lyngby, Denmark
    Nucleic Acids Res 27:370-2. 1999
    ..Sequence logos representing the acceptor specificity patterns for GalNAc, GlcNAc, mannosyl and xylosyl transferases are shown. The O-GLYCBASE database is available through the WWW at http://www.cbs.dtu.dk/databases/OGLYCBASE/..
  34. ncbi Lantibiotics: peptides of diverse structure and function
    Joanne M Willey
    Department of Biology, Hofstra University, Hempstead, New York 11549, USA
    Annu Rev Microbiol 61:477-501. 2007
    ....
  35. ncbi Abnormal histone modification patterns in lupus CD4+ T cells
    Nan Hu
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
    J Rheumatol 35:804-10. 2008
    ..To investigate alterations in histone modifications in patients with systemic lupus erythematosus (SLE)...
  36. ncbi Marking histone H3 variants: how, when and why?
    Alejandra Loyola
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Trends Biochem Sci 32:425-33. 2007
    ..We review and discuss recent knowledge about how the choice and initial modifications of a specific variant might affect PTM states and eventually the final epigenetic state of a chromosomal domain...
  37. ncbi Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins
    M J Mamula
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:22321-7. 1999
    ..Isoaspartyl linkages within proteins are enhanced in aging and stressed cells and arise under physiological conditions. These post-translationally modified peptides may serve as an early immunologic stimulus in autoimmune disease...
  38. ncbi Regulation of p53 responses by post-translational modifications
    Yang Xu
    Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, USA
    Cell Death Differ 10:400-3. 2003
  39. ncbi Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation
    Kah Leong Lim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:2002-9. 2005
    ..Our results suggest that parkin is a dual-function ubiquitin ligase and that K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with PD...
  40. ncbi A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester
    K Elenius
    Department of Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:26761-8. 1997
    ....
  41. ncbi Analysis of dynamic changes in post-translational modifications of human histones during cell cycle by mass spectrometry
    Debora Bonenfant
    Novartis Institutes for BioMedical Research, Lichtstrasse 35, CH 4056 Basel, Switzerland
    Mol Cell Proteomics 6:1917-32. 2007
    ..Our results show that mitosis was the period of the cell cycle during which many modifications exhibit dynamic changes...
  42. pmc The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation
    Lianyun Li
    Building 5, Room 433, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health 5, Center Drive, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1793:346-53. 2009
    ..Our findings suggest a novel mode of A20 action that involves lysosomal targeting of signal molecules bound to A20...
  43. ncbi Modification of proteins by ubiquitin and ubiquitin-like proteins
    Oliver Kerscher
    Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Cell Dev Biol 22:159-80. 2006
    ..The primary aim of this review is to summarize the latest developments in our understanding of the different Ubl-protein modification systems, including the shared and unique features of these related pathways...
  44. doi Crosstalk among Histone Modifications
    Tamaki Suganuma
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell 135:604-7. 2008
    ..Recent studies (Duncan et al., 2008; Lee et al., 2007; Li et al., 2008) reveal that regulation of histone modifications can be functionally linked to reinforce the activation or repression of gene expression...
  45. doi A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, Institute for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mol Cell 32:685-95. 2008
    ..These chromatin modifications act principally through the Rpd3S complex to aid glucose repression of GAL1-10 at physiologically relevant sugar concentrations...
  46. pmc Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2
    Meredith F N Rosser
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 19:4570-9. 2008
    ..Early folding defects are evident upon translation of the NBD1 and R-domain and are sensed by the RMA-1 ubiquitin ligase complex...
  47. ncbi Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
    Trends Biochem Sci 27:489-92. 2002
    ..The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule...
  48. pmc A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products
    Ulrich auf dem Keller
    Department of Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, 4 401 Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
    Mol Cell Proteomics 9:912-27. 2010
    ....
  49. pmc The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes
    Aurine Verkest
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Cell 17:1723-36. 2005
    ..Moreover, the proposed model allowed a dynamical simulation of the in vivo observations, validating the sufficiency of the regulatory interactions between CDKA;1, KRP2, and CDKB1;1 in fine-tuning the mitosis-to-endocycle transition...
  50. ncbi Evidence for the existence of an HP1-mediated subcode within the histone code
    Gwen Lomberk
    Gastroenterology Research Unit, Department of Medicine, and Mayo Clinic Cancer Center, Rochester, MN 55605, USA
    Nat Cell Biol 8:407-15. 2006
    ....
  51. doi Sorting of lysosomal proteins
    Thomas Braulke
    University Medical Center Hamburg Eppendorf, Department Biochemistry, Children s Hospital Research campus, Martinistr 52, 20246, Hamburg, Germany
    Biochim Biophys Acta 1793:605-14. 2009
    ..The complex interaction of both luminal and cytosolic signals with recognition proteins guarantees the specific and directed transport of proteins to lysosomes...
  52. ncbi Regulation of histone methylation by demethylimination and demethylation
    Robert J Klose
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nat Rev Mol Cell Biol 8:307-18. 2007
    ..Here, we examine the enzymatic and structural basis for the mechanisms that these enzymes use to counteract histone methylation and provide insights into their substrate specificity and biological function...
  53. ncbi Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    Mario F Fraga
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 37:391-400. 2005
    ..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells...
  54. ncbi Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
    Daniel E Michele
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 1101, USA
    Nature 418:417-22. 2002
    ....
  55. pmc A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor
    K Fujimura-Kamada
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 136:271-85. 1997
    ..Ste24p and the proteins related to it define a new subfamily of proteins that are likely to function as intracellular, membrane-associated zinc metalloproteases...
  56. pmc Predicting protein post-translational modifications using meta-analysis of proteome scale data sets
    Daniel Schwartz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 8:365-79. 2009
    ..New motif discovery is a byproduct of this approach, and the phosphorylation motif analyses provide strong evidence of evolutionary conservation of both known and novel kinase motifs...
  57. doi Massively regulated genes: the example of TP53
    Monica Hollstein
    LIGHT Laboratories, University of Leeds, Leeds LS2 9JT, UK
    J Pathol 220:164-73. 2010
    ..Presumably this is needed, because the p53 protein can have such profound consequences for a cell...
  58. ncbi Structural insights into microtubule function
    E Nogales
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Annu Rev Biochem 69:277-302. 2000
    ..The combination of structural, genetic, biochemical, and biophysical data should soon give us a fuller understanding of the exquisite details in the regulation of the microtubule cytoskeleton...
  59. pmc Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
    Ali Shilatifard
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Curr Opin Cell Biol 20:341-8. 2008
    ....
  60. pmc Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants
    Andréanne Auger
    Laval University Cancer Research Center, Hôtel Dieu de Québec CHUQ, 9 McMahon St, Quebec City, Quebec G1R 2J6, Canada
    Mol Cell Biol 28:2257-70. 2008
    ..Our results identified the key central subunit for the structure and functions of the NuA4 histone acetyltransferase complex and functionally linked this activity with the histone variant H2AZ from yeast to human cells...
  61. ncbi The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
    D Xue
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 10:1073-83. 1996
    ..Our results suggest that different mammalian CED-3/ICE-like proteases may have distinct roles in mammalian apoptosis and that CPP32 is a candidate for being a mammalian functional equivalent of CED-3...
  62. pmc Multiplex N-terminome analysis of MMP-2 and MMP-9 substrate degradomes by iTRAQ-TAILS quantitative proteomics
    Anna Prudova
    Department of Biochemistry and Molecular Biology, Centre for Blood Research, University of British Columbia, 4 401 Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
    Mol Cell Proteomics 9:894-911. 2010
    ..Hence, N-terminomics analyses using iTRAQ-TAILS links gelatinases with new mechanisms of action in angiogenesis and reveals unpredicted restrictions in substrate repertoires for these two very similar proteases...
  63. pmc Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?
    P A Wilmarth
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, 611 South West Campus Drive, Portland, Oregon 97239, USA
    J Proteome Res 5:2554-66. 2006
    ..On the basis of spectral counting, the most abundant PTMs in aged lenses were deamidations and methylated cysteines with other PTMs present at lower levels...
  64. doi Dynamics of component exchange at PML nuclear bodies
    Stefanie Weidtkamp-Peters
    Leibniz Institute of Age Research, Fritz Lipman Institute, Beutenbergstr 11, 07745 Jena, Germany
    J Cell Sci 121:2731-43. 2008
    ..These findings provide a kinetics model for factor exchange at PML NBs and highlight potential mechanisms to regulate intranuclear trafficking of specific factors at these domains...
  65. ncbi Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins
    G Marques
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697, USA
    Cell 91:417-26. 1997
    ..We propose that formation of the embryonic DPP activity gradient involves the opposing effects of SOG inhibiting DPP and TLD processing SOG to release DPP from the inhibitory complex...
  66. pmc SysPTM: a systematic resource for proteomic research on post-translational modifications
    Hong Li
    Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Proteomics 8:1839-49. 2009
    ..SysPTM could be an important contribution to modificomics research. SysPTM is freely available online at www.sysbio.ac.cn/SysPTM...
  67. ncbi Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p
    Efterpi Papouli
    Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom
    Mol Cell 19:123-33. 2005
    ..Our findings suggest a mechanism by which SUMO and ubiquitin cooperatively control the choice of pathway for the processing of DNA lesions during replication...
  68. pmc Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation
    Carsten Lambert
    Institut fur Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg Universitat Mainz, Augustusplatz, D 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 100:5199-204. 2003
    ..They also hint to the dynamic nature of the mammalian ER translocation machinery in handling co- and posttranslational substrates...
  69. pmc Effect of glycosylation on protein folding: a close look at thermodynamic stabilization
    Dalit Shental-Bechor
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 105:8256-61. 2008
    ....
  70. pmc Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases
    I Yana
    Department of Internal Medicine and the University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Biol Cell 11:2387-401. 2000
    ..These findings demonstrate the existence of a proprotein convertase-MT1-MMP axis that can regulate extracellular matrix remodeling...
  71. pmc Identification of Lassa virus glycoprotein signal peptide as a trans-acting maturation factor
    Robert Eichler
    Institut für Virologie der Philipps Universität Marburg, Robert Koch Strasse 17, D 35037 Marburg, Germany
    EMBO Rep 4:1084-8. 2003
    ..To our knowledge, this is the first report on a signal peptide that is essential for proteolytic processing of a secretory pathway protein...
  72. ncbi Glutaredoxin: role in reversible protein s-glutathionylation and regulation of redox signal transduction and protein translocation
    Melissa D Shelton
    Department of Pharmacology, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, OH 44106 4965, USA
    Antioxid Redox Signal 7:348-66. 2005
    ..Among many proteins under consideration, actin, protein tyrosine phosphatase-1B, and Ras stand out as the best current examples for establishing this regulatory mechanism...
  73. pmc Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator
    Xiu Bao Chang
    Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    J Cell Sci 121:2814-23. 2008
    ..Surprisingly, the individual N-linked carbohydrates do not play equivalent roles and modulate the fate of the wild-type protein in different ways in its early biosynthetic pathway...
  74. ncbi HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability
    Kim Stopak
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Cell 12:591-601. 2003
    ....
  75. ncbi Protein modification by SUMO
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Biochem 73:355-82. 2004
    ..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
  76. ncbi In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation
    Keith W Earley
    Biology Department, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA
    Plant J 52:615-26. 2007
    ..Other acetylation events, including histone H3K9 acetylation, are likely to result from the activities of the broad-specificity HAC1, HAC5, and HAC12 histone acetyltransferases...
  77. pmc Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins
    Vijayakrishna Singu
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    Infect Immun 73:79-87. 2005
    ..Host cell-specific protein expression coupled with posttranslational modifications may be a hallmark for the pathogen's adaptation to a dual-host life cycle and its persistence...
  78. ncbi Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification
    Y Hong
    Department of Biochemistry, Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA
    J Biol Chem 276:40263-7. 2001
    ..Mutation of lysine 298 also results in a significant decrease in stress-induced transcriptional activity of HSF1 in vivo. This work implicates SUMO-1 modification as an important modulator of HSF1 function in response to stress...
  79. pmc The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
    R Shafi
    The Howard Hughes Medical Institute, Glycobiology Research and Training Center, Department of Cellular and Molecular Medicine, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 97:5735-9. 2000
    ....
  80. ncbi Processing of transforming growth factor beta 1 precursor by human furin convertase
    C M Dubois
    Department of Pediatrics, Faculty of Medicine, Universite de Sherbrooke, Quebec, Canada
    J Biol Chem 270:10618-24. 1995
    ..Collectively, these results provide evidence that in our experimental systems the TGF beta 1 precursor is efficiently and correctly processed by human furin thus permitting release of the biologically active peptide...
  81. ncbi Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    R S Jackson
    Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 16:303-6. 1997
    ..In view of the similarity between the proband and the fat/fat mouse phenotype, we infer that molecular defects in prohormone conversion may represent a generic mechanism for obesity, common to humans and rodents...
  82. ncbi Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    E H Schroeter
    Department of Molecular Biology and Pharmacology, Washington University, St Louis, Missouri 63110, USA
    Nature 393:382-6. 1998
    ..Very small amounts of NICD are active, explaining why it is hard to detect in the nucleus in vivo. We also show that it is ligand binding that induces release of NICD...
  83. pmc Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP
    A A McCracken
    University of Nevada, Biology Department, Reno 89557, USA
    J Cell Biol 132:291-8. 1996
    ..Together, these results indicate that cytosolic protein factor(s), ATP hydrolysis, and calnexin are required for ER-associated protein degradation in yeast, and suggest the cytosol as the site for degradation...
  84. ncbi Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
    Veronique A J Smits
    The Wellcome Trust and Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Curr Biol 16:150-9. 2006
    ..Within these pathways, the effector kinase Chk1 plays a central role in mediating cell-cycle arrest in response to DNA damage, and it does so by phosphorylating key cell-cycle regulators...
  85. ncbi Epigenetic regulation by histone methylation and histone variants
    Peter Cheung
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Room 10 516, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 19:563-73. 2005
    ..We also highlight some of the enzymes that mediate histone methylation and discuss the stability and inheritance of this modification...
  86. ncbi Post-translational modifications regulate the ticking of the circadian clock
    Monica Gallego
    Center for Children, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Nat Rev Mol Cell Biol 8:139-48. 2007
    ..Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them...
  87. ncbi Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
    B De Strooper
    Experimental Genetics Group, Flemish Institute for Biotechnology VIB4, Center for Human Genetics, K U Leuven, Belgium
    Nature 391:387-90. 1998
    ..Our results indicate that mutations in PS1 that manifest clinically cause a gain of function and that inhibition of PS1 activity is a potential target for anti-amyloidogenic therapy in Alzheimer's disease...
  88. ncbi Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells
    Natasha E Zachara
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 279:30133-42. 2004
    ..O-GlcNAc regulates both the rates and extent of the stress-induced induction of heat shock proteins, providing a molecular basis for these findings...
  89. pmc SUMOylation and De-SUMOylation: wrestling with life's processes
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:8223-7. 2009
    ..This review will focus on the de-SUMOylating enzymes with special attention to their biological function...
  90. ncbi The presenilins in Alzheimer's disease--proteolysis holds the key
    C Haass
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University Munich, Germany
    Science 286:916-9. 1999
    ..These findings suggest that the presenilins may prove to be valuable molecular targets for the development of drugs to combat AD...
  91. pmc Mechanisms involved in the regulation of histone lysine demethylases
    Fei Lan
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States
    Curr Opin Cell Biol 20:316-25. 2008
    ..The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity...
  92. pmc Single-nucleosome mapping of histone modifications in S. cerevisiae
    Chih Long Liu
    Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 3:e328. 2005
    ..g., promoter nucleosomes) from those at another location (e.g., over the 3' ends of coding regions). These results are consistent with the idea of a simple, redundant histone code, in which multiple modifications share the same role...
  93. ncbi Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    C Du
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Cell 102:33-42. 2000
    ..Overexpression of Smac increases cells' sensitivity to apoptotic stimuli. Smac is the second mitochondrial protein, along with cytochrome c, that promotes apoptosis by activating caspases...
  94. ncbi Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems
    Tony Pawson
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Cell 116:191-203. 2004
    ..Here, I discuss experiments that have led to this view of dynamic cellular behavior and identify some current and future areas of interest in cell signaling...
  95. ncbi Redox proteomics: identification of oxidatively modified proteins
    Pietro Ghezzi
    Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Proteomics 3:1145-53. 2003
    ....
  96. pmc Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
    O Staub
    Hospital for Sick Children, Division of Respiratory Research, Toronto, Ontario, Canada
    EMBO J 16:6325-36. 1997
    ..Our results suggest that ENaC function is regulated by ubiquitination, and propose a paradigm for ubiquitination-mediated regulation of ion channels...
  97. ncbi A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
    C Brou
    Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, Paris, France
    Mol Cell 5:207-16. 2000
    ..Furthermore, experiments carried out on TACE-/- bone marrow-derived monocytic precursor cells suggest that this metalloprotease plays a prominent role in the activation of the Notch pathway...
  98. pmc Phosphorylation of histone H2B at DNA double-strand breaks
    Oscar Fernandez-Capetillo
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 199:1671-7. 2004
    ..Our results broaden the spectrum of histone modifications that constitute the DNA damage "histone code" and suggest a model for the underlying chromatin structure within damage-induced foci...
  99. ncbi Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
    F Uhlmann
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 103:375-86. 2000
    ..Cleavage of Sccl in metaphase arrested cells is sufficient to trigger the separation of sister chromatids and their segregation to opposite cell poles...
  100. doi Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information
    Armelle Corpet
    Laboratory of Nuclear Dynamics and Genome Plasticity, UMR 218 Centre National de la Recherche Scientifique and Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Trends Cell Biol 19:29-41. 2009
    ....
  101. ncbi A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    Jianping Jin
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:709-21. 2006
    ..These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication...

Research Grants99

  1. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2011
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  2. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2010
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  3. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher West; Fiscal Year: 2009
    ..gondii, which is widely disseminated latently in the human population and for which, if it is re-activated, pharmacological therapies are extremely limited. ..
  4. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2010
    ..This proposal will advance public health by determining how PP2A, the primary eukaryotic serine/threonine phosphatase, alters the injurious responses to cigarette smoke exposure in the lung. ..
  5. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen Harris; Fiscal Year: 2007
    ....
  6. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen Harris; Fiscal Year: 2009
    ....
  7. Molecular Mechanisms of Histone Acetyltransferases
    JOHN DENU; Fiscal Year: 2009
    ..Several anti-cancer drugs have already been developed to target certain enzymes involved in this pathway. ..
  8. Molecular Mechanisms of Histone Acetyltransferases
    John M Denu; Fiscal Year: 2010
    ..Several anti-cancer drugs have already been developed to target certain enzymes involved in this pathway. ..
  9. MOLECULAR PHARMACOLOGY OF INSULIN RESISTANCE IN BURNS
    JEEVENDRA MARTYN; Fiscal Year: 2005
    ..The studies together will thus provide significant insights into the pathogenesis of insulin resistance and provide information on novel therapeutic strategies to treat burn, and other stress or inflammation-induced insulin resistance. ..
  10. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    Barry Markaverich; Fiscal Year: 2009
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  11. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2010
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  12. In vivo imaging of X inactivation
    Matthew Levy; Fiscal Year: 2010
    ....
  13. MODIFICATION OF ALPHA-CRYSTALLIN CHAPERONE FUNCTION
    EDATHARA ABRAHAM; Fiscal Year: 2003
    ..We will test the hypothesis that posttranslational modifications affect the chaperone-target protein binding leading to reduced chaperone function. ..
  14. Novel Mechanistic Targets of Steroid Hormones in the Brain
    Meharvan Singh; Fiscal Year: 2007
    ....
  15. The functions of the US3 protein kinase of herpes simplex virus
    Bernard Roizman; Fiscal Year: 2010
    ....
  16. Regulation of structure and function of protein by glycosylation
    Zhiwen Jonathan Zhang; Fiscal Year: 2010
    ....
  17. Regulation of structure and function of protein by glycosylation
    Zhiwen Zhang; Fiscal Year: 2009
    ....
  18. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2004
    ..abstract_text> ..
  19. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora V Thompson; Fiscal Year: 2010
    ..This proposal investigates two key skeletal muscle proteins, Troponin C and myosin light chains, which are candidates to explain age-related muscle dysfunction. ..
  20. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora Thompson; Fiscal Year: 2009
    ..This proposal investigates two key skeletal muscle proteins, Troponin C and myosin light chains, which are candidates to explain age-related muscle dysfunction. ..
  21. Enzymology of Post-translational Modifications
    Carol A Fierke; Fiscal Year: 2010
    ..Identification of the protein substrates and downstream biological function will enhance the development of new therapeutics targeting these pathways. ..
  22. Assays for Screening Histone Modifications in Cancer
    Michael A Freitas; Fiscal Year: 2010
    ....
  23. Biological role of modifications to C/EBPbeta-1 and -2
    Linda Sealy; Fiscal Year: 2007
    ..These studies will provide important insights into how misregulated C/EBPbeta isoform expression may contribute to the development of metastatic mammary carcinoma. ..
  24. Structural Biology of Lysine Methylation in DNA Damage and Checkpoint Signaling
    Georges Mer; Fiscal Year: 2010
    ..The work has relevance to public health because by understanding the mechanisms of these important processes, we may be able to find ways to prevent and treat human malignancies, particularly cancer. ..
  25. Structure and Mechanism of Pathogen SET Domain HKMTs
    Ming Ming Zhou; Fiscal Year: 2009
    ....
  26. Structure and Mechanism of Pathogen SET Domain HKMTs
    Ming Ming Zhou; Fiscal Year: 2007
    ....
  27. The Epileptogenic Effect of Perinatal Hypoxia
    Frances Jensen; Fiscal Year: 2009
    ..The present proposal aims to refine our understanding of this novel antiepileptogenic effect, and potentially elucidate other targets that can be used for therapeutic intervention in this unique population. ..
  28. The Epileptogenic Effect of Perinatal Hypoxia
    Frances E Jensen; Fiscal Year: 2010
    ..The present proposal aims to refine our understanding of this novel antiepileptogenic effect, and potentially elucidate other targets that can be used for therapeutic intervention in this unique population. ..
  29. The Epileptogenic Effect of Perinatal Hypoxia
    Frances Jensen; Fiscal Year: 2009
    ..The present proposal aims to refine our understanding of this novel antiepileptogenic effect, and potentially elucidate other targets that can be used for therapeutic intervention in this unique population. ..
  30. Glycoregulation of Skp1 in the cytoplasm and nucleus
    Christopher M West; Fiscal Year: 2010
    ..The knowledge gained is expected to generate new ideas of how the proteome is regulated in select protists in response to external signals such as O2 and internal signals such as sugar metabolites. ..
  31. Innate immune signal transduction specificity in inflammatory disease
    Derek W Abbott; Fiscal Year: 2011
    ..This work aims to help determine the causes of inflammatory disease and aims to identify novel targets for pharmaceutical intervention in these debilitating disorders. ..
  32. Novel Micro-X-ray Translucent Flow Cell Technology for Proteomics, a Broadly Appl
    EVA BIRNBAUM; Fiscal Year: 2007
    ....
  33. Innate immune signal transduction specificity in inflammatory disease
    Derek W Abbott; Fiscal Year: 2010
    ..This work aims to help determine the causes of inflammatory disease and aims to identify novel targets for pharmaceutical intervention in these debilitating disorders. ..
  34. De Novo Methyltransferase Function in Chromatin and Cancer
    Keith D Robertson; Fiscal Year: 2010
    ....
  35. Identifying and Characterizing Readers of the Neural Histone Code
    Mark Bedford; Fiscal Year: 2007
    ..In this study we plan to investigate how this memory code is read. This basic scientific study will clearly impact the fields of drug addiction, mental retardation and aging diseases of the brain. ..
  36. Myocardial Ischemia-Reperfusion and Protein Phosphatase 2a
    Polly A Hofmann; Fiscal Year: 2010
    ..the heart, can we improve the short and long term outcomes from ischemic events in the heart? Which of the unique PP2aB targeting subunits is key to improving post-ischemic recovery in the heart, and by what mechanisms does this occur? ..
  37. CaaX Protein Processing and Human Disease
    Stephen G Young; Fiscal Year: 2010
    ..Our studies will be focused on the physiologic importance of the B-type lamins in the developing brain and other tissues and the physiologic importance of the posttranslational processing of prelamin A. ..