enzyme induction

Summary

Summary: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

Top Publications

  1. ncbi EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair
    Eric E Gabison
    Unité 532 Inserm, Hopital Saint Louis, Paris 75010, France
    Biochimie 87:361-8. 2005
  2. ncbi Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    Kevin T Connor
    Geomatrix, Inc, Folsom, California, USA
    J Toxicol Environ Health B Crit Rev 9:147-71. 2006
  3. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
  4. ncbi Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress
    Ki Mo Kim
    Department of Immunology, Wonkwang University School of Medicine, Iksan, Chunbug 570 749, Republic of Korea
    Circ Res 101:919-27. 2007
  5. ncbi Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol
    K P Kanebratt
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Clin Pharmacol Ther 84:589-94. 2008
  6. ncbi Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1
    Joachim C U Lehmann
    CRBA Inflammation, Schering AG, Berlin, Germany
    J Invest Dermatol 127:835-45. 2007
  7. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
  8. ncbi Functional expression, inhibition and induction of CYP enzymes in HepaRG cells
    Miia Turpeinen
    Department of Pharmacology and Toxicology, 90014 University of Oulu, Oulu, Finland
    Toxicol In Vitro 23:748-53. 2009
  9. ncbi Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    Ajay Madan
    XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
    Drug Metab Dispos 31:421-31. 2003
  10. pmc Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1707-16. 2003

Detail Information

Publications282 found, 100 shown here

  1. ncbi EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair
    Eric E Gabison
    Unité 532 Inserm, Hopital Saint Louis, Paris 75010, France
    Biochimie 87:361-8. 2005
    ..This review will discuss the recent findings concerning these diverse regulatory mechanisms in various physiological and pathological situations...
  2. ncbi Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    Kevin T Connor
    Geomatrix, Inc, Folsom, California, USA
    J Toxicol Environ Health B Crit Rev 9:147-71. 2006
    ..required approximately 10-fold higher concentrations of TCDD in vitro than rodent cells to respond with enzyme induction. Recent studies of in vivo enzyme induction-related endpoints in human populations with moderately and highly ..
  3. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling...
  4. ncbi Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress
    Ki Mo Kim
    Department of Immunology, Wonkwang University School of Medicine, Iksan, Chunbug 570 749, Republic of Korea
    Circ Res 101:919-27. 2007
    ..Thus, the HO-1/CO system might be potential therapeutics in vascular diseases associated with ER stress...
  5. ncbi Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol
    K P Kanebratt
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Clin Pharmacol Ther 84:589-94. 2008
    ..4-fold, P < 0.05; and 4.2-fold, P < 0.01, respectively). In conclusion, we have shown that the Karolinska cocktail and 4beta-hydroxycholesterol can be used for an initial screening of the induction properties of a drug candidate...
  6. ncbi Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1
    Joachim C U Lehmann
    CRBA Inflammation, Schering AG, Berlin, Germany
    J Invest Dermatol 127:835-45. 2007
    ....
  7. ncbi Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture
    Allan H Conney
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854 8020, USA
    Cancer Res 63:7005-31. 2003
    ..article describes research from my laboratory and related research from other laboratories on the effects of enzyme induction on chemical carcinogenesis as an approach to cancer chemoprevention, as well as studies on the inhibitory ..
  8. ncbi Functional expression, inhibition and induction of CYP enzymes in HepaRG cells
    Miia Turpeinen
    Department of Pharmacology and Toxicology, 90014 University of Oulu, Oulu, Finland
    Toxicol In Vitro 23:748-53. 2009
    ..In conclusion, HepaRG cells may be a promising cell line for various applications, which currently employ hepatic subcellular preparations or cultured primary hepatocytes...
  9. ncbi Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    Ajay Madan
    XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
    Drug Metab Dispos 31:421-31. 2003
    ....
  10. pmc Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1707-16. 2003
    ....
  11. pmc An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
    W Xie
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:3375-80. 2001
    ..Therefore, we establish SXR and PXR as bile acid receptors and a role for the xenobiotic response in the detoxification of bile acids...
  12. ncbi Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages
    Peili Chen
    Stress Signaling Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 169:6408-16. 2002
    ..These findings highlight MKP-1 as a critical negative regulator of the macrophage inflammatory response, underscoring its premise as a potential target for developing novel anti-inflammatory drugs...
  13. ncbi Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, United Kingdom
    J Immunol 164:3018-25. 2000
    ..They also suggest that MSK1 and MSK2 may play a role in these processes and hence are potential targets for the development of novel antiinflammatory drugs...
  14. ncbi Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells
    Monica Ek
    Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Biochem Pharmacol 74:496-503. 2007
    ....
  15. pmc Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro
    Wenyue Hu
    Iconix Biosciences, Inc, 325 E Middlefield Road, Mountain View, CA 94043, USA
    Mol Pharmacol 71:1475-86. 2007
    ....
  16. ncbi Enhancer-mediated control of macrophage-specific arginase I expression
    Anne Laure Pauleau
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Immunol 172:7565-73. 2004
    ..Identification of a powerful extrahepatic regulatory enhancer for arginase I provides potential to manipulate arginase I activity in immune cells while sparing liver urea cycle function...
  17. ncbi Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species
    S P Donald
    Division of Basic Science, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 61:1810-5. 2001
    ..We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX...
  18. ncbi Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells
    S M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol 275:E740-7. 1998
    ..These complex patterns of expression suggest that the arginase isoforms may play distinct, although partially overlapping, functional roles in macrophage arginine metabolism...
  19. ncbi Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection
    Ulrike Protzer
    Molecular Infectiology at Center for Molecular Medicine Cologne, Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany
    Gastroenterology 133:1156-65. 2007
    ..Induction of heme oxygenase-1 (HO-1) has been shown to be beneficial in immune-mediated liver damage. We now investigate the effects of HO-1 induction in models of human hepatitis B virus (HBV) infection...
  20. pmc Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence
    Torsten Klengel
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Curr Biol 15:2021-6. 2005
    ..Novel therapeutic agents could target this pathway at several levels to control fungal infections...
  21. ncbi Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
    Paolo Bergamo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche CNR ISA, Via Roma 52, 83100, Avellino, Italy
    Free Radic Biol Med 43:71-9. 2007
    ..In conclusion our data indicate that the activation of detoxifying enzymes may be one of the mechanisms whereby dietary CLA down-regulates oxidative stress in MRL/lpr mice...
  22. ncbi Induction of drug metabolism: the role of nuclear receptors
    Christoph Handschin
    Division of Pharmacology Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Pharmacol Rev 55:649-73. 2003
    ....
  23. ncbi Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG
    Hye Kyung Na
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Food Chem Toxicol 46:1271-8. 2008
    ..This review summarizes the molecular basis of chemoprevention and cytoprotection afforded by EGCG with emphasis on its ability to modulate Nrf2-mediated cellular events...
  24. ncbi HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
    Marc Lübberstedt
    Division of Experimental Surgery, Berlin Brandenburg Center for Regenerative Therapies BCRT, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Pharmacol Toxicol Methods 63:59-68. 2011
    ..Due to the limited availability of human liver tissue for cell isolation, there is a need of alternative cell sources for pharmaceutical research...
  25. pmc NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure
    R J Flockhart
    Institute of Cellular Medicine, Newcastle University, Framlington Pl, Newcastle upon Tyne NE2 4HH, UK
    FASEB J 22:4218-27. 2008
    ..Taken together, these data suggest that the proinflammatory, antiapoptotic, and procarcinogenic functions of UV-activated COX-2 may be mediated, in part, by upstream NFAT signaling...
  26. ncbi Antidepressants: clinically relevant drug interactions to be considered
    Rene Schellander
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Pharmacology 86:203-15. 2010
    ..When comparing prescription data and observed adverse drug events, there is fortunately a safety gap between the number of potential drug-drug interactions and the number of clinically observed side effects due to drug-drug interactions...
  27. ncbi Comparative oxidative metabolism of BDE-47 and BDE-99 by rat hepatic microsomes
    Claudio A Erratico
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Toxicol Sci 123:37-47. 2011
    ....
  28. ncbi 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction
    Jeong Seok Hwa
    Department of Urology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
    J Ethnopharmacol 139:605-15. 2012
    ..Cinnamomum cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation...
  29. pmc Model-based approach to characterize efavirenz autoinduction and concurrent enzyme induction with carbamazepine
    Min Zhu
    Research and Development, Bristol Myers Squibb, P O Box 4000, Princeton, NJ 08543 4000, USA
    Antimicrob Agents Chemother 53:2346-53. 2009
    Characterization of the time course and magnitude of enzyme induction due to multiple inducers is important for interpretation of clinical data from drug-drug interaction studies...
  30. ncbi Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract
    Stacey A Ritz
    Medical Sciences Division, Northern Ontario School of Medicine, East Campus Laurentian University, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada
    Am J Physiol Lung Cell Mol Physiol 292:L33-9. 2007
    ..Our studies show that sulforaphane can mitigate the effect of diesel in respiratory epithelial cells and demonstrate the chemopreventative potential of phase II enzyme enhancement...
  31. ncbi Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism
    Nadia Amara
    Institut National de la Santé et de la Recherche Médicale U700, Paris, France
    Am J Physiol Lung Cell Mol Physiol 293:L170-81. 2007
    ..We conclude that alveolar alterations secondary to MMP-1 induction could explain lung function impairment associated with exposure to particulate pollution...
  32. ncbi The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies
    David E Amacher
    Sciadvisor Toxicology Consultant, PO Box 254, Hadlyme, CT 06439, USA
    Toxicol Mech Methods 20:159-66. 2010
    ....
  33. ncbi The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29
    Jonathan P Jackson
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 65:1397-404. 2004
    ....
  34. ncbi Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling
    Sangeeta Shrotriya
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Cancer Res 70:1932-40. 2010
    ..Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis...
  35. pmc Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats
    Prabhakara Reddy Nagareddy
    Faculty of Pharmaceutical Sciences, The University of British Columbia, British Columbia, Canada
    Diabetes 58:2355-64. 2009
    ....
  36. ncbi Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles
    Junxiang Wan
    Hart and Louise Lyon Laboratory, Division of Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine, University of California, Los Angeles, California 90095 1690, USA
    Inhal Toxicol 19:177-82. 2007
    ..These findings suggest that overexpression of antioxidant enzymes could constitute a powerful potential chemopreventive approach against adverse effects induced by oxidant pollutants such as DEPs...
  37. ncbi New technologies and screening strategies for hepatotoxicity: use of in vitro models
    Donna M Dambach
    Discovery Toxicology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Toxicol Pathol 33:17-26. 2005
    ....
  38. ncbi Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
    J M Pascussi
    Institut National de la Santé et de la Recherche Médicale U128, Institut Federatif de Recherche 24, Centre National de la Recherche Scientifique, Montpellier, France
    Mol Pharmacol 58:361-72. 2000
    ..These results reveal the existence of functional cross talk between the GR and PXR, and may explain some controversial aspects of the role of the GR in CYP3A4 induction...
  39. ncbi Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Drug Metab Rev 32:81-118. 2000
    The use of primary hepatocytes is now well established for both studies of drug metabolism and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for fresh liver tissue...
  40. ncbi Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes
    Saadet Turkseven
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 289:H701-7. 2005
    ..These observations in experimental diabetes suggest that the vascular cytoprotective mechanism of HO-1 against oxidative stress requires an increase in EC-SOD and catalase...
  41. ncbi Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway
    Z Guan
    Department of Molecular Biology and Pharmacology and Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 273:12901-8. 1998
    ..Together, this data suggests a potential role for the MEKK1 --> SEK1/MKK4 --> p38 MAPK -->--> Cox-2 cascade linking members of the MAPK pathway with prostaglandin biosynthesis...
  42. pmc SXR, a novel steroid and xenobiotic-sensing nuclear receptor
    B Blumberg
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 12:3195-205. 1998
    ..These results strongly support the steroid sensor hypothesis and suggest that broad specificity sensing receptors may represent a novel branch of the nuclear receptor superfamily...
  43. ncbi Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:23847-50. 2004
    ..In the future, use of "humanized" mouse lines, containing a human AHR or CYP1 allele in place of the orthologous mouse gene, is one likely approach to show that the AHR and the CYP1 enzymes in human behave similarly to that in mouse...
  44. ncbi Inhibition of atypical PKC blocks ultraviolet-induced AP-1 activation by specifically inhibiting ERKs activation
    C Huang
    The Hormel Institute, University of Minnesota, Austin 55912, USA
    Mol Carcinog 27:65-75. 2000
    ..These results demonstrated that inhibition of aPKC impairs UV-induced AP-1 activation via suppression of ERKs activation but not of JNKs or p38 kinase activation...
  45. ncbi Comparison of activities dependent on glutathione S-transferase and cytochrome P-450 IA1 in cultured keratinocytes and reconstructed epidermal models
    Ian R Harris
    Paul Gerson Unna Skin Research Center, Beiersdorf AG, Hamburg, Germany
    Skin Pharmacol Appl Skin Physiol 15:59-67. 2002
    ..GST activity in models was equal or higher than the activity in epidermal samples. Reconstructed skin models may be useful to study the effects of non-water-soluble topical formulations on xenobiotic metabolism...
  46. ncbi Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats
    Joseph Fomusi Ndisang
    Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada
    Blood 101:3893-900. 2003
    ..In adult SHRs, the HO/CO-sGC/cGMP system appeared normal, but desensitization of the sGC/cGMP pathway caused hypertension to prevail...
  47. pmc Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction
    Gary J Litherland
    Cell Signalling, Injury and Repair Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 285:22414-25. 2010
    ..aPKCs may constitute potential therapeutic targets for inflammatory joint diseases involving increased collagenase expression...
  48. ncbi Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers
    Stephanie R Faucette
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7360, USA
    Drug Metab Dispos 32:348-58. 2004
    ..These results indicate that CYP2B6 is highly inducible by known CYP3A4 inducers and suggest that hPXR is a major determinant of CYP2B6-inducible expression for many, but not all, compounds evaluated in this study...
  49. ncbi Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in
    P A Harper
    Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
    Mol Pharmacol 40:818-26. 1991
    ..The mechanistic reason for the diminished degree of difference between responsive and nonresponsive mice during embryonic cell culture (compared with adult tissues) is not yet known...
  50. ncbi The AH-receptor: genetics, structure and function
    H I Swanson
    Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611
    Pharmacogenetics 3:213-30. 1993
    ..The objectives of this review are to describe recent experimental results in this field and to use this information to develop a molecular model of AH-receptor mediated signal transduction...
  51. ncbi Induction of heme oxygenase 1 by nitrosative stress. A role for nitroxyl anion
    Patrick Naughton
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, United Kingdom
    J Biol Chem 277:40666-74. 2002
    ..These findings indicate that heme oxygenase can act both as a sensor to and target of redox-based mechanisms involving NO and extend our knowledge on the biological function of HO-1 in response to nitrosative stress...
  52. ncbi Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes
    S Gack
    Forschungszentrum Karlsruhe, Institut fur Genetik, Germany
    Cell Growth Differ 6:759-67. 1995
    ....
  53. ncbi Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts
    T Sameshima
    Department of Neurosurgery, Miyazaki Medical College, 5200 Kihara, Kiyotake, 889 1692, Miyazaki, Japan
    Cancer Lett 157:177-84. 2000
    ..Thus, we have shown, for the first time, that EMMPRIN causes increased expression of MT1-MMP and MT2-MMP, as well as increased production and activation of MMP-2...
  54. ncbi MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?
    A R Clark
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom
    J Endocrinol 178:5-12. 2003
    ..The potential relevance of MKP-1 to some of the biological effects of GCs is discussed...
  55. ncbi Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol
    Helen C Swaisland
    AstraZeneca Pharmaceuticals, Macclesfield, UK
    Clin Pharmacokinet 44:1067-81. 2005
    ..Based on these findings, three clinical studies were carried out to investigate pharmacokinetic drug interactions in vivo with gefitinib...
  56. ncbi Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products
    Judy L Raucy
    California Toxicology Research Institute, Carlsbad, California 92009, USA
    Drug Metab Dispos 31:533-9. 2003
    ..Such results indicate that kava-kava required PXR to mediate CYP3A4 induction. Collectively, results demonstrated that several botancials induce CYP3A4, suggesting the potential for drug-herbal interactions...
  57. pmc Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
    Rosario Jimenez
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, Royal Brompton Hospital, Faculty of Medicine, Imperial College, London SW3 6LY, UK
    Proc Natl Acad Sci U S A 102:4637-42. 2005
    ..These data have important implications for our understanding of the innate immune response in vascular cells and how it may impact vascular disease...
  58. pmc Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock
    C Szabo
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 108:786-92. 1993
    ..The delayed hypotension and vascular hyporeactivity, however, is due to enhanced NO formation by the LPS-induced enzyme...
  59. ncbi The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology
    S Harmsen
    Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Biomedical Analysis, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Cancer Treat Rev 33:369-80. 2007
    ..Understanding of the molecular mechanisms that underlie enzyme induction and the identification of (new) drugs involved in pharmacokinetic drug-drug interactions may contribute to ..
  60. ncbi Enzyme induction in cryopreserved human hepatocyte cultures
    Sabine Kafert-Kasting
    Cytonet GmbH and Co, KG Hannover Branch, Feodor Lynen Strasse 21, D 30625 Hannover, Germany
    Toxicology 220:117-25. 2006
    ..Nevertheless, enzyme induction factors caused by 24 h incubation with 50 microM rifampicin were similar in cryopreserved and non-frozen ..
  61. ncbi Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Chem Biol Interact 125:51-73. 2000
    ....
  62. ncbi Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction
    M Ringel
    Institute of Toxicology, University of Mainz, Germany
    Toxicology 206:153-67. 2005
    ..we optimized an in vitro system with hepatocytes cultured in alginate microspheres that allow studies of enzyme induction with excellent sensitivity...
  63. ncbi Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?
    Cuyue Tang
    Department of Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, West Point, PA 19486 0004, USA
    Drug Metab Dispos 33:603-13. 2005
    ....
  64. ncbi Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs
    Gail D Anderson
    Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
    Neurology 63:S3-8. 2004
    ..The decreased induction and inhibition effects and the lack of significant genetic polymorphism of the newer AEDs allow increased ease of use and perhaps greater safety, especially for patients taking multiple medications...
  65. ncbi Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes
    M Tsuchiya
    Division of Endocrinology and Metabolism, University of Tsukuba, Ibaraki, Japan
    Am J Physiol 258:C841-8. 1990
    ..b>Enzyme induction was supported by the results of kinetic analysis and the inhibition of the insulin-induced increase in enzyme ..
  66. ncbi Enzyme induction with antiepileptic drugs: cause for concern?
    Martin J Brodie
    Epilepsy Unit, Western Infirmary, Glasgow, United Kingdom
    Epilepsia 54:11-27. 2013
    ..Modern AEDs that do not possess this property have similar efficacy for the common epilepsies. Accordingly, perhaps consideration should be given to starting treatment with, or even switching patients to, non-enzyme-inducing AEDs...
  67. ncbi The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction
    Sylvie Klieber
    Discovery Metabolism and Pharmacokinetics Safety, Sanofi Aventis Recherche, Montpellier, France
    Methods Mol Biol 640:295-308. 2010
    ..hepatocytes became the most predictive and widely used in vitro model for drug metabolism studies as well as enzyme induction. For this purpose, well-established and robust in vitro assays for the measurement of cell viability, ..
  68. ncbi Lack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizers
    He Ping Lei
    Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China
    Ann Pharmacother 43:726-31. 2009
    ..Because this enzyme exhibits genetic polymorphism, the inductive effect was expected to be modulated by the CYP2C19 metabolizer status...
  69. pmc Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline
    M C Brandriss
    J Bacteriol 140:498-503. 1979
    ..The arginine-degradative pathway intersects the proline-degradative pathway at P5C. The P5C formed from the breakdown of arginine or ornithine can induce both proline-degradative enzymes by virtue of its conversion to proline...
  70. ncbi Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes
    Mei Fei Yueh
    Puracyp Inc, Carlsbad, CA 92009, USA
    Toxicol In Vitro 19:275-87. 2005
    ..89 and 0.79 microM, respectively. In summary, chemicals that possess the ability to alter CYP1A expression or inhibit CYP1A enzyme activities can be rapidly identified with the cell-based bioassays described here...
  71. ncbi Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis
    Andre Mahns
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    Photochem Photobiol Sci 3:257-62. 2004
    ..UV-induced COX-2 expression is not affected by inhibition of the MEK 1,2/ERK 1,2 pathways...
  72. ncbi Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
    J B Millar
    Division of Yeast Genetics, National Institute for Medical Research, Ridgeway, London, UK
    Genes Dev 9:2117-30. 1995
    ..We conclude that Pyp1 and Pyp2 are tyrosine-specific MAP kinase phosphatases that inactivate an osmoregulated MAP kinase, Sty1, which acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast...
  73. ncbi Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1
    Tomohisa Takagi
    Kyoto Prefectural University of Medicine, Japan
    J Pharmacol Exp Ther 331:255-64. 2009
    ..Phosphorylation of ERK and Nrf2, activation and nuclear translocation of Nrf2, and oxidation of Keap1 are all involved in the lansoprazole-induced HO-1 up-regulation...
  74. ncbi Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation
    Shigeyuki Uno
    Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati Medical Center, OH 45267 0056, USA
    Mol Pharmacol 65:1225-37. 2004
    ....
  75. ncbi Hemin activation ameliorates HIV-1 infection via heme oxygenase-1 induction
    Krishnakumar Devadas
    Immunopathogenesis Section, Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 176:4252-7. 2006
    ..These findings suggest an important role of hemin-induced HO-1 activity as a host defense mechanism against HIV-1 infection...
  76. ncbi The protective effects of oxyresveratrol imine derivative against hydrogen peroxide-induced cell death in PC12 cells
    J Hur
    Korea Food Research Institute, Seongnam, South Korea
    Free Radic Res 47:212-8. 2013
    ..Our results suggest that imine analogs of oxyresveratrol may be useful agents in reducing neuronal oxidative damage...
  77. ncbi Induction of cytochrome P4501A1
    J P Whitlock
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305 5332, USA
    Annu Rev Pharmacol Toxicol 39:103-25. 1999
    ..b>Enzyme induction reflects increased transcription of the cognate CYP1A1 gene...
  78. ncbi Relative impact of genotype and enzyme induction on the metabolic capacity of CYP2C9 in healthy volunteers
    S V Vormfelde
    Department of Clinical Pharmacology, University Medical Center of the Georg August University Göttingen, Gottingen, Germany
    Clin Pharmacol Ther 86:54-61. 2009
    Pharmacokinetics in individual subjects is determined by genes and environment. The relative contributions of enzyme induction and inherited genomic variation to cytochrome P450 enzyme 2C9 (CYP2C9) activity are unknown...
  79. ncbi Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes
    Dirk Roymans
    Preclinical Pharmacokinetics, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Biochem Pharmacol 67:427-37. 2004
    ..In conclusion, cryopreserved human hepatocytes may be a good alternative to fresh hepatocytes to study CYP1A and 3A induction...
  80. ncbi Cell-based models to study hepatic drug metabolism and enzyme induction in humans
    Marc Vermeir
    Johnson and Johnson Pharmaceutical Research and Development, Preclinical Pharmacokinetics, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Expert Opin Drug Metab Toxicol 1:75-90. 2005
    ..The status of model development, their acceptance by health authorities and recommendations for the most appropriate use of the models are presented...
  81. pmc Assessment of enzyme induction and aerenchyma formation as mechanisms for flooding tolerance in Trifolium subterraneum 'Park'
    Samira Aschi-Smiti
    Departement de Biologie, Faculte des Sciences de Tunis, 1060 Tunis, Tunisia
    Ann Bot 91:195-204. 2003
    The objective of this study was to evaluate the role of enzyme induction and aerenchyma formation in prolonged tolerance to soil flooding in a variety of underground clover (Trifolium subterraneum 'Park') previously selected for ..
  82. ncbi [Effects of various ginkgo biloba extracts and proanthocyanidin on hepatic cytochrome P450 activity in rats]
    Tomomi Sugiyama
    National Institute of Health and Nutrition, Tokyo, Japan
    Shokuhin Eiseigaku Zasshi 45:295-301. 2004
    ..Further studies will be necessary to identify the constituent(s) of GBE involved in the induction of CYPs in vivo...
  83. ncbi Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies
    M S Benedetti
    UCB Pharma, Nanterre, France
    Fundam Clin Pharmacol 14:301-19. 2000
    ..Gabapentin, vigabatrin and in particular levetiracetam appear to be devoid of significant enzyme inducing or inhibiting properties...
  84. pmc Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds
    Wael M El-Sayed
    University of Utah, Department of Pharmacology and Toxicology, 30 South 2000 East, Room 201, Salt Lake City, UT 84112, USA
    Toxicol In Vitro 21:157-64. 2007
    ..Thus, Hepa1c1c7 cells appear to provide a viable platform for the study of protective enzyme regulation by selenocompounds, and with the exception of Ugt1a6, the mRNA elevations from selenazolidines are transcriptionally dependent...
  85. ncbi Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions
    Jiansong Yang
    Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield, UK
    Curr Drug Metab 9:384-94. 2008
    ..the accurate prediction of changes in drug concentration-time profiles associated with interactions involving enzyme induction and mechanism (time)-based inhibition (MBI)...
  86. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
    ..Also, unlike isolated cells in culture, the COX and NOS pathways were active independently; L-NAME had little effect on the activity of COX and indomethacin had little effect on the activity of NOS...
  87. ncbi Extrapolation of in vitro enzyme induction data to humans in vivo
    G L Kedderis
    Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709 2137, USA
    Chem Biol Interact 107:109-21. 1997
    b>Enzyme induction generally increases the rate and extent of xenobiotic metabolism in vitro, but physiological constraints can dampen these effects in vivo...
  88. ncbi Enzyme inhibition and induction in liver disease
    Pietro Palatini
    Dipartimento di Farmacologia ed Anestesiologia, Universita di Padova, Largo E Meneghetti 2, 35131 Padova, Italy
    Curr Clin Pharmacol 3:56-69. 2008
    ....
  89. ncbi Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET)
    Parikshit C Das
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Drug Metabol Drug Interact 23:237-60. 2008
    ....
  90. ncbi Coordinated induction of drug transporters and phase I and II metabolism in human liver slices
    P Olinga
    Department of Pharmacokinetics and Drug Delivery, Groningen Research Institute for Pharmacy, University of Groningen, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharm Sci 33:380-9. 2008
    ..The concomitant induction of metabolic enzymes and transporters shows that also in the human liver transporters and metabolic enzymes are regulated coordinately...
  91. ncbi Regulation of inducible AmpC beta-lactamase expression among Enterobacteriaceae
    N D Hanson
    Center for Research in Anti Infectives and Biotechnology, Departments of Pediatrics and Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    Curr Pharm Des 5:881-94. 1999
    ..In doing so, the genes and gene products required for the process of AmpC induction are described. In addition, we review the data addressing cell wall recycling as it relates to AmpC induction...
  92. pmc Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism
    Heather E Ferguson
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Ave, Box 692, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 297:L912-9. 2009
    ....
  93. pmc Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones
    Ryan Holland
    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA CA91032
    Chem Res Toxicol 22:1427-34. 2009
    ....
  94. ncbi Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans
    U Fuhr
    Institute for Pharmacology, Clinical Pharmacology, University of Cologne, Germany
    Clin Pharmacokinet 38:493-504. 2000
    ..b>Enzyme induction has the net effect of increasing protein levels...
  95. ncbi Increased 6-hydroxycortisol excretion in pregnant women: implication of drug-metabolizing enzyme induction
    C Ohkita
    Department of Hospital Pharmacy, Tenri Hospital, Japan
    DICP 24:814-6. 1990
    ..081 +/- 0.031), 6-OHF values one week after delivery were significantly higher than those observed in the control group. These observations suggest that drug-metabolizing enzyme induction may occur during pregnancy.
  96. ncbi Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2
    Susan P Rhodes
    Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, USA
    J Pharmacol Toxicol Methods 63:223-6. 2011
    ....
  97. pmc Near completely humanized liver in mice shows human-type metabolic responses to drugs
    Chise Tateno
    Yoshizato Project, Cooperative Link of Unique Science and Technology for Economy Revitalization CLUSTER, Hiroshima, Japan
    Am J Pathol 165:901-12. 2004
    ..We conclude that the chimeric mouse developed in the present study is a useful model for assessing the functions and pharmacological responses of human hepatocytes...
  98. ncbi Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats
    Y Deng
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Xenobiotica 38:465-81. 2008
    ..Further study is needed to elucidate the mechanism of CYP3A induction by EGb 761 and bilobalide...
  99. ncbi Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis
    Craig D Fisher
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel, Tucson, AZ 85721, USA
    Arch Toxicol 82:959-64. 2008
    ..4) Hepatic Nqo1 mRNA levels were significantly increased by the MCD diet; however, additional induction of Nqo1 was still achievable following treatment with the Nrf2 activator OPZ...
  100. ncbi Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man
    Daniela Ennulat
    GlaxoSmithKline, King of Prussia, Pennsylvania 19406 0939, USA
    Toxicol Pathol 38:810-28. 2010
    ..Importantly, hepatic DME induction and associated changes in preclinical species are not necessarily predictive of the occurrence, magnitude, or enzyme induction profile in humans.
  101. pmc CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines
    Shigeyuki Uno
    Department of Biochemistry, Nihon University School of Medicine, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Toxicol Appl Pharmacol 237:119-26. 2009
    ..These findings are relevant to risk assessment involving human CYP1A1 and CYP1A2 substrates, when administered to mice as environmental toxicants or drugs...

Research Grants62

  1. Mitochondrial DNA Repair and Biogenesis
    Raquel R Bartz; Fiscal Year: 2013
    ..the AMP-kinase pathway activation in sepsis as it relates to nuclear co-activator function and mtDNA repair enzyme induction. The completion of these Aims will improve our understanding of the role of mtDNA damage and repair in severe ..
  2. Isothiocyanate-Mediated Breast Cancer Prevention
    Louise R Howe; Fiscal Year: 2013
    ..against rodent breast neoplasia induced by carcinogen treatment, most likely as a consequence of Phase II enzyme induction and resultant acceleration of carcinogen deactivation...
  3. In vivo effects of sulforaphane supplementation on normal human prostate
    Daniel W Lin; Fiscal Year: 2013
    ..biopsy) and prostatectomy to assess carefully selected and evaluated measures of phase II detoxifying enzyme induction, intra-prostatic steroid hormone metabolism, oxidative damage, and growth of prostate cancer cells...
  4. Micro-Liver Platform Development for Evaluating Drug Disposition and Toxicity In
    SALMAN KHETANI; Fiscal Year: 2010
    ..primary human hepatocytes are considered to be the gold standard for evaluating preclinical drug metabolism, enzyme induction, and liver-specific toxicity...
  5. NQO2: A novel target to reduce oxidative stress in retinal pigment epithelium
    CHRISTOPHER KWAN HWANG; Fiscal Year: 2011
    ..While some evidence suggests involvement of antioxidant enzyme induction, the mechanism of this protection is essentially unknown...
  6. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1991
    ..These studies will form the basic for the overall objective of evaluating the effect of age, nutritional status, and biologic response modifiers on drug metabolism, induction and toxicity in extrahepatic tissues...
  7. CHRONOBIOLOGICAL INVESTIGATION OF TNF AND IL-2
    William Hrushesky; Fiscal Year: 1992
    ..modulates glucocorticoid receptor binding, decreases available binding sites and reduces steroid-associated enzyme induction. These steroid/cytokine interactions suggest that chronobiologic investigation of cytokine toxicity and ..
  8. CHLOROANILINE-INDUCED NEPHROTOXICITY
    GARY RANKIN; Fiscal Year: 1992
    ..The role of toxic metabolites will be investigated using enzyme induction and inhibition studies, glutathione depletion studies, quantitation of covalent binding of chloroanilines to ..
  9. ALKYLATING AGENTS AND DRUG RESISTANCE
    Kenneth Tew; Fiscal Year: 1999
    ..Using a battery of cDNA probes and isozyme specific antibodies, techniques will be applied which measure enzyme induction at both the mRNA and protein levels...
  10. ENZYME INDUCTION DEFECT--IMPLICATION FOR TOXICITY
    Robert Blouin; Fiscal Year: 1992
    ..The specific aims of the project are: a) to investigate the enzyme induction defect in the fa/fa rodent, to determine if the defect is the result of an inheritable defect in the PB ..
  11. NOVEL CHARACTERISTICS OF 1-IMIDAZOLE ENZYME INDUCTION
    Michael Franklin; Fiscal Year: 1990
    ..The overall findings will provide greater accuracy to the prediction of drug-drug interactions likely to arise from the therapeutic use of N- substituted imidazoles...
  12. 1-Cys-peroxiredoxin, A Novel Lung Anti-oxidant Enzyme
    Aron Fisher; Fiscal Year: 2004
    ..To study tolerance in vivo, rats and mice will be exposed to hyperoxia; enzyme induction (mRNA, protein, activity) will be measured in control and selenium deficient rats exposed to 80 percent or ..
  13. REGULATION OF MUCOSAL IMMUNITY BY VITAMIN D3
    RAYMOND DAYNES; Fiscal Year: 2005
    ..We will evaluate if such enzyme induction may represent a natural way to promote mucosal immunity to antigens delivered via the skin...
  14. INDUCTION OF AMINOLEVULINIC ACID SYNTHASE BY EXERCISE
    David Essig; Fiscal Year: 1993
    ..Finally, we will isolate the gene for rat AS to eventually determine the sequence elements involved in AS enzyme induction. The results of this work may establish one of the pathways utilized by muscle cells to effect an overall ..
  15. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..Several patterns of enzyme induction, i.e...
  16. EUCARYOTIC ENZYME INDUCTION: B-GALACTOSIDASE IN YEAST
    Robert Dickson; Fiscal Year: 1991
    ..The information obtained from these studies will aid our understanding of more complex regulatory phenomena including cellular differentiation, environmental adaptation, and disease states such as cancer...
  17. ENVIRONMENTAL POLLUTANTS--THE INTESTINE AND NUTRITION
    JAMES MANIS; Fiscal Year: 1980
    ..Intestinal and hepatic enzyme induction will be measured as benzo(a)pyrene hydroxylase (aryl hydrocarbon hydroxylase) concurrently in order to ..
  18. NITRIC OXIDE & GUANYLATE CYCLASE IN LUNG CIRCULATION
    Don Nakayama; Fiscal Year: 2000
    ..The up regulation of iNOS and GTP-CH results from enzyme induction by inflammatory cytokines, principally TNFa and IFNg...
  19. PUTATIVE MEDIATORS OF INSULIN SECRETION
    SUZANNE LAYCHOCK; Fiscal Year: 2000
    ..adenosine monophosphate-mediated protein kinase (AMPK) and acetyl-CoA carboxylase activity, and antioxidant enzyme induction/activation...
  20. Dithiole thiones and ones--Chemistry to Biochemistry
    JAMES FISHBEIN; Fiscal Year: 2005
    ..However, a major area of uncertainty is the molecular nature of the initiation steps involved in Phase 2 enzyme induction. As elaborated in this proposal, this is in part due to the dearth of information regarding the chemistry and ..
  21. PRIMATE ENDOCRINE REGULATION IN THE PERINATAL PERIOD
    Robert Jaffe; Fiscal Year: 2003
    ..adrenal gland is to cardinal importance because of 1) the pivotal role adrenal corticosteroids play in early enzyme induction, the coordinate development of independent organ systems necessary or intrauterine homeostasis and ..
  22. Mechanism of Anticarcinigenic Effects of Myristicin
    HASSAN AHMAD; Fiscal Year: 2004
    ..The results are expected to help us understand the Phase-II enzyme induction by myristicin and its potential in developing pharmacologically effective dietary strategies for cancer ..
  23. TOXICITY OF PURE PCBS FOR RHESUS MONKEYS
    WILBUR MC NULTY; Fiscal Year: 1980
    ..and the kinetics of storage of parent compound in fat and liver and the pattern of hepatic microsomal enzyme induction will be determined for each isomer...
  24. Oxidation Hypothesis--Paradoxes and Pitfalls
    Sampath Parthasarathy; Fiscal Year: 2006
    ..we propose that "oxidative stress in plasma might result in an elevated tissue (arterial) antioxidant enzyme induction and, in addition, such oxidative stress might itself could lead to lower plasma cholesterol levels...
  25. INTERACTIONS OF L-ACETYLMETHADOL WITH METHADONE
    FRANCIS TSE; Fiscal Year: 1980
    ..Incidence of drug metabolizing enzyme induction or inhibition will be investigated, and the effect of these changes on the distribution and elimination of ..
  26. AMINO ACID REGULATORY INTERACTIONS IN YEAST
    Richard Weiss; Fiscal Year: 1980
    ..The kinetics of enzyme induction and repression will be compared to that observed when arginine is added to the growth medium...
  27. CONTROL OF GENE EXPRESSION BY DIOXIN
    James Whitlock; Fiscal Year: 2001
    ..In humans, TCDD produces adaptive and adverse effects (enzyme induction, chloracne); however, the risk that TCDD poses to public health is a matter of current debate...
  28. Novel Transcription Profiling in Toxicologic Assays
    Mary Warren; Fiscal Year: 2005
    ..This is due to the many adverse drug reactions and drug-drug interactions that result from drug metabolism, enzyme induction or inhibition of drug metabolizing enzymes...
  29. ANTICONVULSANT, DRUG-INDUCED MINERAL DISORDERS
    THEODORE HAHN; Fiscal Year: 1980
    ..Finally, studies of drug effects on in vitro hepatic vitamin D metabolism will further define the role of microsomal enzyme induction in this disorder.
  30. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  31. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  32. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  33. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
  34. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  35. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  36. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  37. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  38. ENHANCED APOPTOSIS BY TARGETING PROTEIN REDOX STATUS
    Mohan Natarajan; Fiscal Year: 2009
    ..abstract_text> ..
  39. CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Nestor Gonzalez Cadavid; Fiscal Year: 2008
    ..We expect that our studies would lead to the detection of novel targets of antifibrotic therapy for penile and vascular diseases of considerable public health impact. [unreadable] [unreadable] [unreadable]..
  40. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
    ....
  41. Fibronectin Fragment-Induced Osteolysis Mediated by MMPs
    Sunil Kapila; Fiscal Year: 2009
    ..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..
  42. Coordinate Regulation of Uptake and Efflux Transporters
    Curtis D Klaassen; Fiscal Year: 2010
    ....
  43. Molecular mechanisms of synapse lose by polo kinases
    Daniel T Pak; Fiscal Year: 2010
    ..abstract_text> ..
  44. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  45. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ....
  46. Clinical and Molecular Evaluation of Cancer Therapy Induced Mucositis
    Sharon Gordon; Fiscal Year: 2007
    ..Demonstration of safety and tolerability will provide a basis to test further this route of administration. Hence, this proposal holds promise for clinical application in a relatively short period. [unreadable] [unreadable]..
  47. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  48. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  49. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
    ..The suppressive effects of the kinase inhibitors on activation-associated microglial functions; i.e., targeting of oligodendrocytes and myelin phagocytosis will be tested using in vitro models. ..
  50. Prostate Cancer: A Mouse Model Testing 15-Lipoxygenase-1
    Uddhav Kelavkar; Fiscal Year: 2004
    ..abstract_text> ..
  51. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  52. IVIVC MODEL FOR RENAL DRUG CLEARANCE
    Thomas Dowling; Fiscal Year: 2005
    ..abstract_text> ..
  53. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  54. ADVANCES IN SELENIUM SUPPLEMENTATION
    Michael Franklin; Fiscal Year: 2006
    ..abstract_text> ..
  55. Gene Targets of Wnt Signaling in Pancreatic Cancer
    Andrew Lowy; Fiscal Year: 2006
    ..Our long-range goal is to understand how these genes contribute to pancreatic carcinogenesis with the hope that they can be modulated for therapeutic purposes. ..
  56. Selective Induction of Estrogen Conjugative Metabolism
    Bao Ting Zhu; Fiscal Year: 2006
    ..These studies will also provide examinations of the important roles of bioactive estrogen metabolites (e.g., 4-OH-E2 and 16alpha-OH-E2) in estrogen-induced cancers. ..
  57. Nitric oxide synthase 3 and left ventricular remodeling
    KENNETH BLOCH; Fiscal Year: 2006
    ..Improved understanding of the role of NOS3 in ventricular remodeling may lead to the development of novel therapeutic approaches to preventing congestive heart failure and its associated morbidity and mortality after MI. ..
  58. Effects of ethanol and CYP2E1 on liver function
    Arthur Cederbaum; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  59. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..