enzymologic gene expression regulation


Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

Top Publications

  1. ncbi GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repression
    J C Jauniaux
    Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
    Eur J Biochem 190:39-44. 1990
  2. pmc Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinase
    Lizhong Xiong
    Department of Plant Pathology and Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Plant Cell 15:745-59. 2003
  3. pmc Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 177:4121-30. 1995
  4. ncbi An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
    Jennifer D Davidson
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    Cancer Res 64:3761-6. 2004
  5. pmc Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
    Y Suzuki
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:8662-7. 2001
  6. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
  7. pmc Overexpression of polygalacturonase in transgenic apple trees leads to a range of novel phenotypes involving changes in cell adhesion
    Ross G Atkinson
    The Horticulture and Food Research Institute of New Zealand, Mount Albert Research Centre, Private Bag 92 169, Auckland, New Zealand
    Plant Physiol 129:122-33. 2002
  8. ncbi Regulation of the expression of inducible nitric oxide synthase
    Hartmut Kleinert
    Department of Pharmacology, Johannes Gutenberg University, D 55101 Mainz, Germany
    Biol Chem 384:1343-64. 2003
  9. pmc Estrogen directly activates AID transcription and function
    Siim Pauklin
    DNA Editing Laboratory, Cancer Research UK, Clare Hall Laboratories, South Mimms, EN6 3LD, England, UK
    J Exp Med 206:99-111. 2009
  10. ncbi Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999

Detail Information

Publications334 found, 100 shown here

  1. ncbi GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repression
    J C Jauniaux
    Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
    Eur J Biochem 190:39-44. 1990
    ..J. Biochem. 133, 135-139]. Northern analysis of GAP1-specific transcripts in wild-type and in mutant strains is in agreement with these views and indicates that nitrogen catabolite repression of GAP1 synthesis occurs at the RNA level...
  2. pmc Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinase
    Lizhong Xiong
    Department of Plant Pathology and Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Plant Cell 15:745-59. 2003
    ..These results strongly suggest that OsMAPK5 can positively regulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectrum disease resistance...
  3. pmc Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    L M Guzman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 177:4121-30. 1995
    ..We have exploited the tight regulation of the PBAD promoter to study the phenotypes of null mutations of essential genes and explored the use of pBAD vectors as an expression system...
  4. ncbi An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
    Jennifer D Davidson
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    Cancer Res 64:3761-6. 2004
    ..The results from this study indicate that the level of RRM1 may affect gemcitabine response. Furthermore, RRM1 may serve as a biomarker for gemcitabine response...
  5. pmc Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
    Y Suzuki
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 98:8662-7. 2001
    ..These results demonstrate that the ubiquitin-protein ligase activity of XIAP promotes the degradation of caspase-3, which enhances its anti-apoptotic effect...
  6. pmc Nitric oxide synthases: structure, function and inhibition
    W K Alderton
    In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
    Biochem J 357:593-615. 2001
    ..Highly selective inhibitors of iNOS versus eNOS and neuronal NOS have been identified and some of these have potential in the treatment of a range of inflammatory and other conditions in which iNOS has been implicated...
  7. pmc Overexpression of polygalacturonase in transgenic apple trees leads to a range of novel phenotypes involving changes in cell adhesion
    Ross G Atkinson
    The Horticulture and Food Research Institute of New Zealand, Mount Albert Research Centre, Private Bag 92 169, Auckland, New Zealand
    Plant Physiol 129:122-33. 2002
    ..The modification of apple trees by a single PG gene has offered a new and unexpected perspective on the role of pectin and cell wall adhesion in leaf morphology and stomatal development...
  8. ncbi Regulation of the expression of inducible nitric oxide synthase
    Hartmut Kleinert
    Department of Pharmacology, Johannes Gutenberg University, D 55101 Mainz, Germany
    Biol Chem 384:1343-64. 2003
    ..The induction of iNOS can be inhibited by a wide variety of immunomodulatory compounds acting at the transcriptional levels and/or post-transcriptionally...
  9. pmc Estrogen directly activates AID transcription and function
    Siim Pauklin
    DNA Editing Laboratory, Cancer Research UK, Clare Hall Laboratories, South Mimms, EN6 3LD, England, UK
    J Exp Med 206:99-111. 2009
    ..We therefore suggest that estrogen-induced autoimmunity and oncogenesis may be derived through AID-dependent DNA instability...
  10. ncbi Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
  11. pmc Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex
    Takaaki Daimon
    Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
    J Biol Chem 283:15271-9. 2008
    ..This anomalous presence of the beta-fructofuranosidase gene in the B. mori genome may partly explain why the silkworm can circumvent the mulberry's defense system...
  12. ncbi Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases
    S Lorenzl
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street Room A 501, New York, NY 10021, USA
    J Neurol Sci 207:71-6. 2003
    ..These findings show that TIMPs are elevated in the CSF of patients with neurodegenerative diseases suggesting a potential role of these endogenous inhibitors of matrix metalloproteinases in neurodegenerative diseases...
  13. ncbi Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential
    Cristina Angeloni
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Agric Food Chem 57:5615-22. 2009
  14. ncbi Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs
    Susumu Imaoka
    Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan
    Drug Metab Pharmacokinet 20:478-84. 2005
    ..A systematic analysis of P450 expression in various tissues and of its catalytic property may provide valuable information on the physiological roles of P450s in each tissue...
  15. pmc Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
    William R Henderson
    Center for Allergy and Inflammation, Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Exp Med 204:865-77. 2007
    ..These data direct attention to sPLA(2)-X as a novel therapeutic target for asthma...
  16. pmc 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer
    Michael G Backlund
    Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 6838, USA
    J Biol Chem 280:3217-23. 2005
    ..In summary, these results suggest a novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression...
  17. ncbi Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1
    B Li
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    J Biol Chem 276:29729-39. 2001
    ..Finally, gel shift assays suggested that p53 competes with Sp1 protein for binding to the P4 sequence of the POLD1 promoter...
  18. ncbi Matrix metalloproteinases: a tail of a frog that became a prince
    Constance E Brinckerhoff
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nat Rev Mol Cell Biol 3:207-14. 2002
    ..Structural, molecular and biochemical approaches have subsequently contributed to piecing together the puzzle of how MMPs work, and how they contribute to various disease processes...
  19. ncbi The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases
    G D Brown
    Department of Medical Biochemistry MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, 7505, Tygerberg, South Africa
    Gene 254:147-55. 2000
    ..Mycosin-2 was modified by cleavage in all three mycobacterial species. The multiplicity and constitutive expression of these proteins suggests that they have an important role in the biology of M. tuberculosis...
  20. ncbi The glyoxylate cycle is required for fungal virulence
    M C Lorenz
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA
    Nature 412:83-6. 2001
  21. ncbi CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    S Herzig
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nature 413:179-83. 2001
    ..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
  22. ncbi Mitogen-activated protein kinase cascades and regulation of gene expression
    B Su
    Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston 77030, USA
    Curr Opin Immunol 8:402-11. 1996
    ..An emerging topic of great interest is the basis for specificity in the activation of individual MAPKs and their ability to recognize their substrates...
  23. ncbi Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members
    Tomomi Izumikawa
    Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 283:11396-406. 2008
    ..Based on these results, we renamed CSGlcA-T chondroitin synthase-3 (ChSy-3)...
  24. pmc A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties
    Tobias G Köllner
    Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
    Plant Cell 20:482-94. 2008
    ..We argue that the (E)-beta-caryophyllene defense signal was lost during breeding of the North American lines and that its restoration might help to increase the resistance of these lines against agronomically important pests...
  25. pmc Activation of gibberellin biosynthesis and response pathways by low temperature during imbibition of Arabidopsis thaliana seeds
    Yukika Yamauchi
    Plant Science Center, RIKEN, Institute of Physical and Chemical Research, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Plant Cell 16:367-78. 2004
  26. pmc A nonsense mutation in a cinnamyl alcohol dehydrogenase gene is responsible for the Sorghum brown midrib6 phenotype
    Scott E Sattler
    Grain, Forage, and Bioenergy Research Unit, United States Department of Agriculture Agricultural Research Service, Nebraska, USA
    Plant Physiol 150:584-95. 2009
    ..These differences include His-57, which is unique to Bmr6 and other grass CADs. In summary, Bmr6 encodes the major CAD protein involved in lignin synthesis in sorghum, and the bmr6 mutant is a null allele...
  27. pmc The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
    Pascale Daran-Lapujade
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
    Proc Natl Acad Sci U S A 104:15753-8. 2007
    ..Within the 50-20% hierarchical regulation of fluxes, transcription played a minor role, whereas regulation of protein synthesis or degradation was the most important. These also contributed to 75-100% of the regulation of protein levels...
  28. ncbi Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins
    Tetsuya Okuda
    Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    J Biol Chem 281:10230-5. 2006
    ..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
  29. ncbi Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase
    Young Mee Yoon
    National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
    J Biol Chem 277:8412-20. 2002
  30. ncbi The PINOID protein kinase regulates organ development in Arabidopsis by enhancing polar auxin transport
    R Benjamins
    Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, Wassenaarseweg 64, Leiden, The Netherlands
    Development 128:4057-67. 2001
    ..We propose that PINOID is involved in the fine-tuning of polar auxin transport during organ formation in response to local auxin concentrations...
  31. pmc Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiae
    Federica Ortelli
    Liverpool School of Tropical Medicine, Vector Biology Research Group, Pembroke Place, Liverpool L3 5QA, UK
    Biochem J 373:957-63. 2003
    ..Only GSTE2-2 was able to metabolize DDT. Western blots using antibodies raised against these GSTs indicated that the expression of GSTE2-2 is elevated in a DDT-resistant strain of A. gambiae...
  32. ncbi Rho-family GTPases: it's not only Rac and Rho (and I like it)
    Krister Wennerberg
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    J Cell Sci 117:1301-12. 2004
    ..Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation...
  33. ncbi Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    Eiji Furuta
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
    Cancer Res 68:1003-11. 2008
  34. ncbi Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction
    Marina R Bergman
    Department of Medicine, San Francisco Department of Veterans Affairs Medical Center University of California, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 292:H1847-60. 2007
    ..5 +/- 1.5 vs. MMP 4.7 +/- 2.0; P = 0.016). Expression of active MMP-2 is sufficient to induce severe ventricular remodeling and systolic dysfunction in the absence of superimposed injury...
  35. pmc Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
    Imran N Mungrue
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 109:735-43. 2002
    ..This dramatic cardiac phenotype was rescued by specific attenuation of transgene activity. These data implicate cardiomyocyte iNOS overexpression as sufficient to cause cardiomyopathy, bradyarrhythmia, and sudden cardiac death...
  36. ncbi Histone deimination antagonizes arginine methylation
    Graeme L Cuthbert
    Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 118:545-53. 2004
    ..The recruitment of PADI4 coincides with deimination of the histone H3 N-terminal tail. These results define deimination as a novel mechanism for antagonizing the transcriptional induction mediated by arginine methylation...
  37. pmc The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS protein
    Hyun Sook Chae
    Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Plant Cell 15:545-59. 2003
    ..These results suggest that an important mechanism by which ethylene biosynthesis is controlled is the regulation of the stability of ACS, mediated at least in part through the C-terminal domain...
  38. ncbi F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
    D Skowyra
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 91:209-19. 1997
    ..SCF complexes couple protein kinase signaling pathways to the control of protein abundance...
  39. ncbi Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    P J Lee
    Division of Pulmonary and Critical Care, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:5375-81. 1997
    ..Taken together, these data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response...
  40. ncbi The metabolism of proline, a stress substrate, modulates carcinogenic pathways
    James M Phang
    Laboratory of Comparative Carcinogenesis, Center for Cancer Research, Building 538, Room 115, NCI Frederick, Frederick, MD 21702, USA
    Amino Acids 35:681-90. 2008
    ..In a manner analogous to autophagy, this proline-dependent process for bioenergetics from collagen in extracellular matrix can be designated "ecophagy"...
  41. pmc A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    W Tirasophon
    Department of Biological Chemistry and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Genes Dev 12:1812-24. 1998
    ..These results demonstrate that hIre1p is an essential proximal sensor of the unfolded protein response pathway in mammalian cells...
  42. pmc A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana
    T Mizoguchi
    Laboratory of Plant Molecular Biology, Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Proc Natl Acad Sci U S A 93:765-9. 1996
  43. ncbi p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis
    S Perwez Hussain
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Cancer Res 64:2350-6. 2004
    ..These results identify a novel mechanism of p53-dependent apoptosis in which p53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress...
  44. pmc Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    Richard S Jope
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Sparks Center 1057, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
    Neurochem Res 32:577-95. 2007
    ..Thus, GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions...
  45. ncbi Plant biotin-containing carboxylases
    Basil J Nikolau
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Arch Biochem Biophys 414:211-22. 2003
    ..This minireview summarizes the recent developments in our understanding of the structure, regulation, and metabolic functions of these proteins in plants...
  46. ncbi Isochorismate synthase is required to synthesize salicylic acid for plant defence
    M C Wildermuth
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:562-5. 2001
    ..Here we show, by cloning and characterizing an Arabidopsis defence-related gene (SID2) defined by mutation, that SA is synthesized from chorismate by means of ICS, and that SA made by this pathway is required for LAR and SAR responses...
  47. pmc Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors
    K J Sales
    Department of Medical Biochemistry, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
    J Clin Endocrinol Metab 86:2243-9. 2001
  48. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
  49. ncbi The oxidative pentose phosphate pathway: structure and organisation
    Nicholas J Kruger
    Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
    Curr Opin Plant Biol 6:236-46. 2003
    ..These strategies make it possible to quantify flux through metabolic networks and to discriminate between pathways of carbohydrate oxidation in the cytosol and plastids...
  50. pmc Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
    Amira Zaky
    Department of Biochemistry and Molecular Biology, Sealy Center for Molecular Medicine, University of Texas Medical Branch, TX 77555, Galveston, USA
    Nucleic Acids Res 36:1555-66. 2008
    ..Taken together, our results demonstrate that WTp53 is a negative regulator of APE1 expression, so that repression of APE1 by p53 could provide an additional pathway for p53-dependent induction of apoptosis in response to DNA damage...
  51. ncbi Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice
    Nilda M Munoz
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 179:4800-7. 2007
    ..Our data demonstrate that gVPLA2 is a critical messenger enzyme in the development of AHR and regulation of cell migration during immunosensitization by a pathway that is independent of group IVa phospholipase A2...
  52. ncbi Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeri
    Nils Hartmann
    Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Mech Ageing Dev 130:290-6. 2009
    ..We further conclude that the extremely short lifespan of the GRZ strain is not caused by diminished telomerase activity or accelerated telomere shortening...
  53. ncbi Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation
    Dongping Li
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 277:27772-81. 2002
  54. ncbi Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
    M Wick
    Bayer AG, Central Research Division, Department of Molecular Biology, D 51368, Leverkusen, Germany
    Gene 232:97-106. 1999
    ..Altogether, these results provide the basis for more detailed studies on the regulation of telomerase activity in normal and cancer cells, and may lead to the development of new cancer therapies...
  55. ncbi Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 119:288-96. 2006
    ..Regional DNA hypermethylation may be associated with renal tumorigenesis from a precancerous condition to malignant progression and become a predictor of patient prognosis...
  56. ncbi 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
    Ido Wolf
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Cancer Res 66:7818-23. 2006
    ..Our results indicate for the first time that 15-PGDH may be a novel tumor suppressor gene in breast cancer, and suggest that this enzyme can modulate the ER pathway...
  57. ncbi Identification of a promoter region responsible for the senescence-specific expression of SAG12
    Y S Noh
    Department of Biochemistry, University of Wisconsin, Madison 53706 1544, USA
    Plant Mol Biol 41:181-94. 1999
    ..Extracts from young and senescent Arabidopsis leaves contain factors that exhibit differential binding to the senescence-responsive promoter element...
  58. ncbi Regulation of acetyl-CoA carboxylase
    R W Brownsey
    Department of Biochemistry and Molecular Biology and The Diabetes Research Group of the Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
    Biochem Soc Trans 34:223-7. 2006
    ..This review traces the path and implications of studies initiated with Dick Denton in Bristol in the late 1970s, through to current proteomic and other approaches that have been consistently challenging and immensely rewarding...
  59. ncbi A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes
    Toshio Fujimoto
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:6296-302. 2002
    ..We conclude that the 2G allele has stronger promoter activity in amnion cells, that it confers increased responsiveness of amnion cells to stimuli that induce MMP-1, and that this polymorphism contributes to the risk of PPROM...
  60. ncbi Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
    Abdelhamid Liacini
    Département de Médecine and Centre de Recherche du Centre Hospitalier de l Université de Montréal, Hôpital Notre Dame du CHUM, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Matrix Biol 21:251-62. 2002
    ..Inhibition of IL-1 signal transduction by these agents could be useful for reducing cartilage resorption by MMPs in arthritis...
  61. ncbi Pectin: cell biology and prospects for functional analysis
    W G Willats
    Centre for Plant Sciences, University of Leeds, UK
    Plant Mol Biol 47:9-27. 2001
  62. ncbi In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells
    Javier A Menendez
    Department of Medicine, Breast Cancer Translational Research Laboratory, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois 60201, USA
    J Cell Biochem 94:1-4. 2005
    ..These findings, altogether, support the "metabolic oncogene" theory for FAS overexpression in cancer cells...
  63. ncbi The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormone
    K F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Biochem Soc Trans 34:1256-60. 2006
    ..The results indicate that these Halloween genes are transcriptionally regulated to support the high biosynthetic activity that produces the cyclic ecdysteroid pulses triggering moulting...
  64. pmc Biochemical and molecular characterization of AtPAP26, a vacuolar purple acid phosphatase up-regulated in phosphate-deprived Arabidopsis suspension cells and seedlings
    Vasko Veljanovski
    Department of Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    Plant Physiol 142:1282-93. 2006
    ..As AtPAP26 also exhibited alkaline peroxidase activity, a potential additional role in the metabolism of reactive oxygen species is discussed...
  65. ncbi Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors
    Anne Marie Lefrançois-Martinez
    Unité Mixte de Recherche 6547 CNRS Université Blaise Pascal Clermont II, Génétique des Eucaryotes et Endocrinologie Moléculaire, Complexe Universitaire des Cézeaux, 63177 Aubiere, France
    J Clin Endocrinol Metab 89:3010-9. 2004
    ..This might take part in adrenal tumorigenesis and could be investigated as a marker of malignancy for the diagnosis of adrenal tumors...
  66. ncbi Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Blood 108:4178-86. 2006
    ..In multivariate analysis, this correlation was no longer significant. Altogether, these results suggest that the PI3K/AKT pathway may be a potential target for therapeutic intervention in DLBCL...
  67. ncbi MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    H Sun
    Cold Spring Harbor Laboratory, New York 11724 2208
    Cell 75:487-93. 1993
    ..The mutant 3CH134 protein also forms a physical complex with the phosphorylated form of p42MAPK. These findings suggest that 3CH134 is a physiological MAP kinase phosphatase; we propose the name MKP-1 for this phosphatase...
  68. pmc Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6
    R Desikan
    Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, United Kingdom
    Plant Physiol 126:1579-87. 2001
    ..These data suggest that harpin activates several signaling pathways, one leading to stimulation of the oxidative burst and others leading to the activation of AtMPK4 or AtMPK6...
  69. pmc Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Cell 16:144-56. 2004
  70. pmc Down-regulation of caffeic acid o-methyltransferase in maize revisited using a transgenic approach
    Joel Piquemal
    Signaux et Messages Cellulaires chez les Vegetaux, Unite Mixte de Recherche, Centre National de la Recherche Scientifique Université Paul Sabatier, Pole de Biotechnologie Vegetale, Castanet Tolosan, France
    Plant Physiol 130:1675-85. 2002
    ..To our knowledge, this is the first time that an AS strategy has been applied to modify lignin biosynthesis in a grass species...
  71. ncbi Enhancement of stress tolerance in transgenic tobacco plants overexpressing Chlamydomonas glutathione peroxidase in chloroplasts or cytosol
    Kazuya Yoshimura
    Advanced Life Science, Graduate School, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
    Plant J 37:21-33. 2004
  72. ncbi Cyclooxygenase isozymes and their gene structures and expression
    Tadashi Tanabe
    Department of Pharmacology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Prostaglandins Other Lipid Mediat 68:95-114. 2002
    ..Moreover, MAPK signaling pathways are involved in regulating COX-2 gene expression at the post-transcriptional level...
  73. ncbi Transcriptional regulation of a rice mitogen-activated protein kinase gene, OsMAPK4, in response to environmental stresses
    Shin Feng Fu
    Department of Biology, National Cheng Kung University, No 1 University Road 701, Tainan, Taiwan
    Plant Cell Physiol 43:958-63. 2002
    ..These results suggest that this OsMAPK4 functions not only in developmental programs but also in stress-signaling pathways...
  74. ncbi The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:4225-31. 2003
  75. ncbi Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 352:1967-76. 2005
    ..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
  76. ncbi Function of a mitogen-activated protein kinase pathway in N gene-mediated resistance in tobacco
    Hailing Jin
    Department of Plant and Microbial Biology, University of California, Berkeley and Plant Gene Expression Center, USDA ARS, 800 Buchanan St, Albany, CA 94710, USA
    Plant J 33:719-31. 2003
  77. ncbi Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells
    Min Hyuk Yoo
    Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:13005-8. 2006
    ..These observations provide direct evidence that the reduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime target for cancer therapy...
  78. ncbi Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy
    Dineo Khabele
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee 37208, USA
    Cancer Biol Ther 6:795-801. 2007
    ..Taken together, the present studies offer several novel findings that have direct relevance for the strategic use of inhibitors that target Class I HDACs, particularly HDAC3, in the treatment of ovarian cancer...
  79. ncbi Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells
    Wu Guo Deng
    Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:26460-70. 2007
    ..Our results demonstrate the tumor-specific activation of the hTERT promoter by AP-2beta and imply the potential of AP-2beta as a novel tumor marker or a cancer therapeutic target...
  80. pmc Salt-induced expression of the vacuolar H+-ATPase in the common ice plant is developmentally controlled and tissue specific
    D Golldack
    Department of Physiology and Biochemistry of Plants, Faculty of Biology, University of Bielefeld, D-33501 Bielefeld, Germany
    Plant Physiol 125:1643-54. 2001
  81. ncbi Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
    C Song
    Department of Physiology II, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:2752-7. 2001
    ..These results indicate that Ras directly regulates phosphoinositide breakdown through membrane targeting of PLCepsilon...
  82. pmc Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability
    Xiaodong Bao
    Higuchi Biosciences Center, Department of Pharmacology and Toxicology, and Life Span Studies Institute, University of Kansas, Lawrence, KS 66047, USA
    J Neurosci 29:13929-44. 2009
    ..The Glud1 mouse might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes...
  83. ncbi Caspase 3 expression in benign prostatic hyperplasia and prostate carcinoma
    S A Boran
    Department of Surgery, Mater Misericordiae Hospital, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    Prostate 47:183-8. 2001
    ..CONCLUSIONS: Altered caspase 3 expression may represent an additional mechanism of apoptotic resistance to androgen ablation. Prostate 47:183-188, 2001...
  84. ncbi Histone acetylases and deacetylases in cell proliferation
    T Kouzarides
    Wellcome CRC Institute, Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Opin Genet Dev 9:40-8. 1999
    ..Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer...
  85. ncbi FLEXIBLE CULM 1 encoding a cinnamyl-alcohol dehydrogenase controls culm mechanical strength in rice
    Xiangjun Li
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Mol Biol 69:685-97. 2009
    ..Our results indicated that FC1 plays an important role in the biosynthesis of lignin and the control of culm strength in rice...
  86. ncbi Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain
    S Avraham
    Deaconess Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 270:27742-51. 1995
    ..The structural features of RAFTK suggest that it is a member of the focal adhesion kinase gene family and may participate in signal transduction in human megakaryocytes and brain as well as in other cell types...
  87. pmc A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression
    C Nirodi
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 276:9366-74. 2001
    ..Furthermore, 3-aminobenzamide, an inhibitor of PARP-specific ADP-ribosylation, inhibits CXCL1 promoter activity and reduces levels of CXCL1 mRNA. The data point to the possibility that PARP may be a coactivator of CXCL1 transcription...
  88. ncbi c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism
    S R Eberhardy
    University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 276:48562-71. 2001
    ..In summary, our results suggest that c-Myc activates transcription of cad by stimulating promoter clearance and elongation, perhaps via recruitment of P-TEFb...
  89. ncbi Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cancer Biol Ther 4:585-92. 2005
    ..Infection of KAS 6/1 cells with a recombinant adenovirus carrying the MnSOD cDNA reduced the cell proliferation rate by approximately one-half, confirming the detrimental effects of epigenetic silencing of SOD-2 expression...
  90. ncbi The nitric oxide-cGMP pathway may mediate communication between sensory afferents and projection neurons in the antennal lobe of Manduca sexta
    A Nighorn
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    J Neurosci 18:7244-55. 1998
    ..The expression patterns of these genes suggest that the NO-sGC signaling system may play a role in mediating communication between olfactory receptor neurons and projection neurons in the glomeruli of the antennal lobe...
  91. ncbi Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence
    O Goldshmidt
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    J Biol Chem 276:29178-87. 2001
  92. ncbi The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis
    Eva R Chin
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Rd, MS8220 3120, Groton, CT 06340, USA
    Proc Nutr Soc 63:279-86. 2004
    ..Future studies will be important in determining whether insights from the adaptational response of muscle to increased loads will provide pharmacological approaches for increasing muscle strength or endurance to counter muscle wasting...
  93. ncbi Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
    S Wang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:501-9. 1998
    ..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
  94. ncbi Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene
    S P Kwak
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
    J Biol Chem 269:3596-604. 1994
    ..The potential significance of a second cdc25 homology domain of CL100 is discussed...
  95. ncbi Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1
    Myungsoo Joo
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    J Biol Chem 279:6658-65. 2004
    ..We speculate that a combinatorial role of PU.1 and C/EBP-beta mediates the robust production of COX-2 products by macrophages which occurs in Gram-negative bacterial sepsis...
  96. ncbi An unusual member of the Cdk family: Cdk5
    Fatema A Dhariwala
    Department of Life Sciences, Sophia College, B Desai Road, Mumbai 400026, India
    Cell Mol Neurobiol 28:351-69. 2008
    ..This review focuses on the role of Cdk5 in neural cells as regulator of cytoskeletal elements, axonal guidance, membrane transport, synaptogenesis and cell survival in normal and pathological conditions...
  97. pmc Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogaster
    James T Warren
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 99:11043-8. 2002
    ..Expression of dib and sad continues to be localized in this endocrine compartment during larval development, being maximal in both the late second and third instar larvae, about the time of the premolt peaks in the ecdysteroid titer...
  98. ncbi MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis
    Chung Fai Wong
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    J Biol Chem 283:9836-43. 2008
    ..These results reveal a model of regulation during myogenesis whereby the up-regulation of miR-26a acts to post-transcriptionally repress Ezh2, a known suppressor of skeletal muscle cell differentiation...
  99. ncbi Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response
    A W Blackstock
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27156, USA
    Clin Cancer Res 7:3263-8. 2001
    ..To test this hypothesis, we examined dFdCyd/dFdCTP uptake and clearance in HT-29 human colon carcinoma xenografts in nude mice by high-performance liquid chromatography (HPLC) and fluorine-19 magnetic resonance spectroscopy (F-19 MRS)...
  100. ncbi Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase 1 and topoisomerase IIalpha genes by p21(WAF1/CIP1/SDI1)
    Hongming Zhu
    Department of Molecular Genetics, University of Illinois at Chicago, 60607 7170, USA
    Cell Cycle 1:59-66. 2002
    ..These results indicate that inhibition of cell division-associated genes by p21 is mediated by different but overlapping mechanisms, which are not a general con-sequence of cell cycle arrest...
  101. ncbi Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells
    S D Desai
    Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Cancer Res 61:5926-32. 2001

Research Grants81

  1. Control of Vascular Smooth Muscle Function by Insulin
    Louis Ragolia; Fiscal Year: 2006
    ..abstract_text> ..
  2. Novel Proapoptotic BH3-only Proteins in Cancer Apoptosis
    Chien An Hu; Fiscal Year: 2009
    ..Deciphering functions of the novel BH3-only proteins and their interacting molecules should enhance our understanding, and potential utilization, of BH3-only proteins and lipid-mediated apoptosis in treatment of cancer. ..
  3. Symposium on Selenium in Biology and Medicine
    ROGER SUNDE; Fiscal Year: 2006
    ..The breath and depth of this meeting and its participants will help to better integrate this information, leading to additional advances and enhanced understanding of human health. [unreadable] [unreadable]..
  4. Development of molecular biology-based assays for human selenium status
    ROGER SUNDE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Sir2 regulation and chemical modulation
    Anthony A Sauve; Fiscal Year: 2010
    ..abstract_text> ..
  6. TCDD Impairs Prostate Development: Cyp2c39 & Retinoids
    CHAD VEZINA; Fiscal Year: 2008
    ..abstract_text> ..
  7. Role of Lamin B Receptor in Neutrophil Maturation and Functional Activation
    Peter Gaines; Fiscal Year: 2007
    ..The results may also offer important insight into the pathogenesis of potentially fatal hematologic disorders. [unreadable] [unreadable] [unreadable]..
  8. Hypothalamic fMRI response to nutrients
    Jonathan Purnell; Fiscal Year: 2007
    ..These studies will help us to better understand why changes in the diet might lead to weight gain or loss. [unreadable] [unreadable] [unreadable]..
    RAJINDAR SOHAL; Fiscal Year: 2007
    ..Thus, it will also provide a further critical test of the validity of oxidative stress hypothesis of aging. ..
  10. Ethanol Effects on Human Astroglial Chemokine Expression
    Randall Davis; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  12. Roles of PTP 1B Overexpression in Pathogenesis in vivo
    JANICE ZABOLOTNY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  14. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  15. Roles of PTP1B in Insulin and Leptin Action in vivo
    JANICE ZABOLOTNY; Fiscal Year: 2006
    ..Kahn, an expert in characterizing animal models of obesity and diabetes, and Dr. Elmquist, an expert in mapping leptin-responsive pathways in the CNS, will provide an exemplary environment for my research. ..
  16. Estrogen, androgen, neprilysin, and amyloid peptides.
    Louis Hersh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Charles Farber; Fiscal Year: 2008
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..
  18. 2008 NOX Family NADPH Oxidases Gordon Conference
    WILLIAM NAUSEEF; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
    David Hein; Fiscal Year: 2009
    ..We also will assess the effect of NAT1 and NAT2 genotypes in breast cancer risk through participation in ongoing molecular epidemiology investigations of breast cancer in Shanghai China and in Nashville, Tennessee. ..
  20. Metabolomics of the Virus-host Cell Interaction
    Joshua D Rabinowitz; Fiscal Year: 2010
    ..Such pathways, once identified, will be attractive new targets for antiviral therapy. ..
  21. CITED2 and Mechanical Loads
    Hui Bin Sun; Fiscal Year: 2010
  22. HOXB4 Is An Activator of HSC Self-Renewal
    Guy Sauvageau; Fiscal Year: 2009
    ..This aim combines cell purification of newly characterized HSC populations with microarray analysis from small cell numbers and preliminary target gene validation. ..
  23. Fibronectin Fragment-Induced Osteolysis Mediated by MMPs
    Sunil Kapila; Fiscal Year: 2009
    ..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..
    Richard Stewart; Fiscal Year: 2009
    ..Our results will help to define general concepts about regulation and clustering of receptor-kinase complexes. ..
    Noralane Lindor; Fiscal Year: 2007
    ..fs20\par \par } ..
  26. Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulation
    Warren Nothnick; Fiscal Year: 2008
    ..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. [unreadable] [unreadable] [unreadable]..
  27. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
    Sunil Kapila; Fiscal Year: 2008
    ..The meeting will be limited to 250 participants who have a background in bioengineering. ..
  29. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
    Serdar Bulun; Fiscal Year: 2008
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  31. Stretch Mediated Myoblast Proliferation and/or Survival
    JEFFREY OTIS; Fiscal Year: 2006
    ..Understanding the molecular mechanisms that regulate muscle growth is important for developing effective pharmacologic or genetic therapies to combat the number of clinical conditions associated with muscle atrophy. ..
  32. Genetic Analysis of Vascular Aging
    Steven Miller; Fiscal Year: 2003
    ..abstract_text> ..
  33. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
    Wei Chen; Fiscal Year: 2002
    ..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..
  35. Sex steroid, HPA regulation, and fat patterning
    Jonathan Purnell; Fiscal Year: 2003
    ..abstract_text> ..
    Changyi Chen; Fiscal Year: 2002
  37. Enzymes of Skin Lipid Metabolism
    David Russell; Fiscal Year: 2009
    ..The research is relevant to skin disease, dry eye syndrome, and cholesterol metabolism. ..
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
    RONALD HINES; Fiscal Year: 2003
    ..It will be critical for the future rationale design of drugs and therapeutic regimens, as well as for the development of prevention/intervention strategies for at risk individuals or populations. ..
    PETER SYAPIN; Fiscal Year: 2003
    ..The results will have broad implications for understanding ethanol effects on CNS gene expression, which is proposed to underlie chronic behavioral and pathophysiologic effects of alcohol. ..
    RICHARD ZAGER; Fiscal Year: 2001
  42. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  43. Anti-Inflammatory PAF Acetylhydrolase in Lung Injury
    Katherine Howard; Fiscal Year: 2004
    ..Through the logical design of the proposed studies, novel and important information will be gained that will significantly advance our understanding of the cell biology of this important anti-inflammatory enzyme. ..
  44. Craniofacial Imaging in the 21st Century
    Sunil Kapila; Fiscal Year: 2002
    ..The meeting will be limited to 300 participants who have a background in imaging. This symposia series will provide momentum to discoveries that will be important to craniofacial sciences and patient care. ..
    Louis Hersh; Fiscal Year: 2004
    BRUCE BERKOWITZ; Fiscal Year: 2001
    ..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
    RONALD HINES; Fiscal Year: 2002
    ..There also is substantial involvement of new personnel as Chairs and co-Chairs. Thus, the Mechanism of Toxicity GRC is poised to continue its growth as the single leading small conference on Molecular Toxicology. ..
  49. Epidermal Mechanisms Opposing Ceramide-Induced Apoptosis
    Yoshikazu Uchida; Fiscal Year: 2009
    Changyi Chen; Fiscal Year: 2002
  51. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
    LAWRENCE LOEB; Fiscal Year: 2002
  53. Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Changyi Chen; Fiscal Year: 2008
    ..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
  54. Role of the 5-Lipoxygenase Pathway in Atherosclerosis
    Hooman Allayee; Fiscal Year: 2009
  55. Novel Roles for MMP-8 in Acute Lung Injury
    Caroline Owen; Fiscal Year: 2008
    ..We anticipate that in the future, our studies will facilitate the development of new treatment strategies that may reduce mortality and morbidity in ALl syndromes. ..
    RAJINDAR SOHAL; Fiscal Year: 2004
    ..Results of this study will provide an understanding of the mechanisms by which CoQ intake may have a beneficial or deleterious effect on the aging process in mice. ..
    ROBERT BRUEGGEMEIER; Fiscal Year: 2006
    ..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
  58. Migraine Headache Treatment by Drug Aerosol Inhalation
    Joshua Rabinowitz; Fiscal Year: 2004
    ..Accomplishment of the goals of Phase II will lead directly to human clinical testing of a commercially viable device that could improve the lives of millions of people every year. ..
  59. Attenuation of astroglial chemokine expression by beta-funaltrexamine: implicatio
    Randall Davis; Fiscal Year: 2008
    ..This training will lend to the success of these students in their future careers in health related professions. [unreadable] [unreadable] [unreadable]..
    Karl Nath; Fiscal Year: 2001
    ..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
    Palmer Taylor; Fiscal Year: 2003
    ..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
  62. Nicotinic Receptor Template-guided Drug Design
    Palmer Taylor; Fiscal Year: 2008
    ..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
  63. Curcumin-based analogs as improved inhibitors of Abeta aggregation
    ROBERT ORLANDO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Palmer Taylor; Fiscal Year: 2008
    ..abstract_text> ..
    DONATO ROMAGNOLO; Fiscal Year: 2003
    ..Specific aim #3 will examine the function of BRCA-1 in cell cycle regulation at different levels of genotoxic damage induced by PAHs. ..
    ROBERT ORLANDO; Fiscal Year: 2003
    Michael Caparon; Fiscal Year: 2004
    ..Since most of these genes are unique, a number of promising candidate drug targets may be identified. ..
    JESSE ROBERTS; Fiscal Year: 2004
    ..In addition, a carefully constructed training program has been developed that will permit successful development of an independent research career examining the basic mechanisms of pulmonary vascular diseases. ..
  69. Repair of DNA breaks in humans: the role of Rad54 protein
    Alexander Mazin; Fiscal Year: 2008
    ..Here we will characterize these interactions and their effect on the enzymatic activities of both hRad54 and Mus81/Eme1 (Aim 4). ..
    Ambrose Cheung; Fiscal Year: 2009
    ..Upon the completion of these studies, we hope to understand how sae is activated in vivo and what target genes sae impacts during infection. ..
  71. Binding and regulation mechanism for S aureus
    Ambrose Cheung; Fiscal Year: 2006
    ..An understanding of these mechanisms will facilitate the development of novel agents that interfere with the function of the SarA family and the ensuing synthesis of cell wall adhesins and toxins. ..
  72. H.pylori Effects on DNA Repair in Gastric Epithelium
    Antonia Sepulveda; Fiscal Year: 2008
    ..Knowledge gained from this study is likely to support the indication for Hp eradication in H. pylori-infected patients to prevent GC. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  73. A Screen for Modulators of Human Rad51, a Key DNA Repair Protein
    Alexander Mazin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  74. Central ACE2, Blood Pressure Regulation and Hypertension
    Eric Lazartigues; Fiscal Year: 2008
    ..Evidence of a role of ACE2 in the regulation of BP could lead to the development of new therapeutics as well as a better utilization of existing therapeutics for the treatment of hypertension and other CV diseases. ..
  75. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
    Eric Howard; Fiscal Year: 2002
    ..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
  77. Cellular Immune Response of Mosquitoes to Pathogens
    JULIAN HILLYER; Fiscal Year: 2003
    ..In understanding the immune response mounted by different insect species and strains toward pathogens, it may be possible to manipulate existing vectors to make the parasite/vector biologic interplay incompatible. ..