developmental gene expression regulation

Summary

Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Top Publications

  1. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
  2. pmc Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
    Tomasz Czechowski
    Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany
    Plant Physiol 139:5-17. 2005
  3. pmc Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
  4. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  5. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
  6. pmc Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
  7. ncbi An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    N C Lau
    Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 294:858-62. 2001
  8. pmc Multipotent cell lineages in early mouse development depend on SOX2 function
    Ariel A Avilion
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 17:126-40. 2003
  9. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
  10. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996

Detail Information

Publications290 found, 100 shown here

  1. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
  2. pmc Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
    Tomasz Czechowski
    Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany
    Plant Physiol 139:5-17. 2005
    ..The developed PCR primers or hybridization probes for the novel reference genes will enable better normalization and quantification of transcript levels in Arabidopsis in the future...
  3. pmc Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
    ..These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal...
  4. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ....
  5. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
    ..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
  6. pmc Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
    ..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
  7. ncbi An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    N C Lau
    Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 294:858-62. 2001
    ..The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals...
  8. pmc Multipotent cell lineages in early mouse development depend on SOX2 function
    Ariel A Avilion
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 17:126-40. 2003
    ..5 days postcoitum. Our data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation...
  9. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
    ..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies...
  10. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  11. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
    ..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
  12. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  13. ncbi Polycomb complexes repress developmental regulators in murine embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 441:349-53. 2006
    ..Our results indicate that dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development...
  14. ncbi p63 is a p53 homologue required for limb and epidermal morphogenesis
    A A Mills
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 398:708-13. 1999
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  15. pmc Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
    Katsuhiko Hayashi
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell Stem Cell 3:391-401. 2008
    ....
  16. ncbi The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    Kaoru Mitsui
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
    Cell 113:631-42. 2003
    ..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells...
  17. ncbi SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
    ..Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells...
  18. ncbi Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    H Niwa
    Centre for Genome Research, The University of Edinburgh, King s Buildings, Edinburgh, UK
    Nat Genet 24:372-6. 2000
    ....
  19. ncbi Stability and flexibility of epigenetic gene regulation in mammalian development
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nature 447:425-32. 2007
    ..It is not known whether any of the epigenetic marks has a primary role in determining cell and lineage commitment during development...
  20. pmc Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
    ..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states...
  21. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
  22. pmc Control of developmental regulators by Polycomb in human embryonic stem cells
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 125:301-13. 2006
    ..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
  23. ncbi Controlling morpholino experiments: don't stop making antisense
    Judith S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 135:1735-43. 2008
    ..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
  24. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  25. ncbi DNA methylation patterns and epigenetic memory
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Genes Dev 16:6-21. 2002
  26. ncbi Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G1X5, Canada
    Dev Cell 10:615-24. 2006
    ..We propose a model in which the ICM develops as a mosaic of EPI and PE progenitors at E3.5, dependent on Grb2-Ras-MAP kinase signaling, followed by later segregation of the progenitors into the appropriate cell layers...
  27. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  28. ncbi A heterogeneous expression pattern for Nanog in embryonic stem cells
    Amar M Singh
    Department of Pathology, University of Florida College of Medicine, Box 100275, Gainesville, Florida 32610, USA
    Stem Cells 25:2534-42. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  29. ncbi Wnt/beta-catenin signaling in development and disease
    Hans Clevers
    Hubrecht Laboratory and Utrecht University, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
    Cell 127:469-80. 2006
    ..Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues...
  30. doi Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
    Eric Dessaud
    Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Development 135:2489-503. 2008
    ..We discuss recent advances in our understanding of these events and highlight unresolved questions...
  31. pmc Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes
    Milo J Aukerman
    E I duPont de Nemours and Company, Agriculture and Nutrition, Newark, Delaware 19711, USA
    Plant Cell 15:2730-41. 2003
    ..Gain-of-function and loss-of-function analyses indicate that two of the AP2-like target genes normally act as floral repressors, supporting the notion that miR172 regulates flowering time by downregulating AP2-like target genes...
  32. pmc Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system
    Steven W Flavell
    F M Kirby Neurobiology Center, Children s Hospital Boston, and Departments of Neurology and Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 31:563-90. 2008
    ....
  33. ncbi Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    A E Pasquinelli
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Nature 408:86-9. 2000
    ..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
  34. pmc The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 16:2813-28. 2002
    ..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
  35. ncbi RAS is regulated by the let-7 microRNA family
    Steven M Johnson
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 120:635-47. 2005
    ..let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer...
  36. ncbi Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    Ian Chambers
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland
    Cell 113:643-55. 2003
    ..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity...
  37. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ....
  38. ncbi Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 453:930-4. 2008
    ..Our results open up the field, permitting further characterization of the molecular mechanisms regulating sex determination and how they have evolved, as well as how they fail in cases of sex reversal...
  39. ncbi Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    Brian D Harfe
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Cell 118:517-28. 2004
    ..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
  40. pmc Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation
    Shaun D Fouse
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:160-9. 2008
    ..Our data suggest that in mES cells promoter methylation represents a unique epigenetic program that complements other regulatory mechanisms to ensure appropriate gene expression...
  41. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
  42. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  43. ncbi Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
    Takaki Miyata
    Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Saitama 351 0198, Japan
    Development 131:3133-45. 2004
    ..The asymmetric P/P division may therefore contribute to efficient neuron/progenitor segregation required for CP initiation through cell cycle-dependent and lineage-restricted expression of Ngn2...
  44. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation...
  45. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis...
  46. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    ..These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death...
  47. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  48. ncbi The transcriptome profile of human embryonic stem cells as defined by SAGE
    Mark Richards
    Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital, Singapore
    Stem Cells 22:51-64. 2004
    ....
  49. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
    ..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
  50. ncbi Making or breaking the heart: from lineage determination to morphogenesis
    Deepak Srivastava
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
    Cell 126:1037-48. 2006
    ....
  51. ncbi Prediction of plant microRNA targets
    Matthew W Rhoades
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
    Cell 110:513-20. 2002
    ..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages...
  52. pmc Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species
    Annie Rochette
    Research Centre in Infectious Diseases, CHUL Research Centre and Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada
    BMC Genomics 9:255. 2008
    ....
  53. ncbi Math1: an essential gene for the generation of inner ear hair cells
    N A Bermingham
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 284:1837-41. 1999
    ..Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells...
  54. ncbi Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes
    Michael Korenjak
    Lehrstuhl für Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munchen, Germany
    Cell 119:181-93. 2004
    ..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure...
  55. ncbi The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
    E G Moss
    Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
    Cell 88:637-46. 1997
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
  56. ncbi Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
    Y Y Kisanuki
    Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
    Dev Biol 230:230-42. 2001
    ..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
  57. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  58. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  59. doi Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
    Toshiaki Watanabe
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 453:539-43. 2008
    ..Our results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous siRNAs from naturally occurring dsRNAs...
  60. ncbi Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
    Anna L M Ferri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Development 131:3805-19. 2004
    ..These findings highlight a crucial and unexpected role for Sox2 in the maintenance of neurones in selected brain areas, and suggest a contribution of neural cell proliferative defects to the pathological phenotype...
  61. ncbi Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
    Jeremy S Dasen
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
    Cell 134:304-16. 2008
    ..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map...
  62. pmc The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Genes Dev 23:1870-5. 2009
    ..Thus, Hes1-null ES cells display less heterogeneity in both the differentiation timing and fate choice, suggesting that the cyclic gene Hes1 contributes to heterogeneous responses of ES cells even under the same environmental conditions...
  63. ncbi A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development
    Thomas Sandmann
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Dev Cell 10:797-807. 2006
    ..The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated...
  64. ncbi T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
  65. ncbi Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    P S Danielian
    Department of Molecular and Cellular Biology Harvard University 16 Divinity Avenue, Cambridge Massachusetts 02138 USA
    Curr Biol 8:1323-6. 1998
    ..Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo...
  66. ncbi A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    G Hutvagner
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 293:834-8. 2001
    ..Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA-processing enzyme Dicer to produce the active small-RNA component that represses gene expression...
  67. pmc MicroRNA regulation of cardiovascular development
    Kimberly R Cordes
    Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
    Circ Res 104:724-32. 2009
    ..Further analysis of miRNA function during cardiovascular development will allow us to determine the potential for novel miRNA-based therapeutic strategies...
  68. ncbi salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    Nicolas Tapon
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
    Cell 110:467-78. 2002
    ..The human ortholog of salvador (hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis...
  69. ncbi The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
    P Jay
    Centre de Recherches de Biochimie Macromoleculaire, CNRS ERS 115, INSERM U 249, Montpellier, France
    Nat Genet 17:357-61. 1997
    ..A complete lack of NDN expression in PWS brain and fibroblasts indicates that the gene is expressed exclusively from the paternal allele in these tissues and suggests a possible role of this new gene in PWS...
  70. pmc Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes
    Cassandra R Farthing
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
    PLoS Genet 4:e1000116. 2008
    ..Epigenetic reprogramming in the germline prior to fertilisation and the reprogramming of key pluripotency genes in the early embryo is thus crucial for transmission of pluripotency...
  71. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  72. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  73. pmc Various spatiotemporal expression profiles of anther-expressed genes in rice
    Tokunori Hobo
    Bioscience and Biotechnology Center, Nagoya University, Furocho, Chikusa, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:1417-28. 2008
    ....
  74. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  75. pmc Identification of genes required for embryo development in Arabidopsis
    Iris Tzafrir
    Department of Botany, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Plant Physiol 135:1206-20. 2004
    ..These candidates should facilitate the recovery of additional genes required for seed development...
  76. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
  77. pmc Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    Paul Gadue
    Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1496, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:16806-11. 2006
    ....
  78. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
    ..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
  79. ncbi Genome regulation by polycomb and trithorax proteins
    Bernd Schuettengruber
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Cell 128:735-45. 2007
    ..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
  80. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ....
  81. ncbi Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control
    R Gualdi
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Genes Dev 10:1670-82. 1996
    ..The findings also provide insight into the evolutionary origin of different endodermal cell types...
  82. ncbi The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis
    Jeong Hoe Kim
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant J 36:94-104. 2003
    ..These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues...
  83. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  84. ncbi Targeted mutagenesis of Tsix leads to nonrandom X inactivation
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02115, USA
    Cell 99:47-57. 1999
    ..Therefore, counting, choice, and silencing are genetically separable. Contrasting effects in XX and XY cells argue that negative and positive factors are involved in choosing active and inactive Xs...
  85. ncbi Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis
    Ruth Diez del Corral
    Division of Cell and Developmental Biology, Life Sciences Faculty, University of Dundee, UK
    Bioessays 26:857-69. 2004
    ....
  86. doi Medaka vasa is required for migration but not survival of primordial germ cells
    Mingyou Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan, China
    Mech Dev 126:366-81. 2009
    ..Taken together, medaka vasa is cell-autonomously required for PGC migration, but dispensable to PGC proliferation, motility, identity and survival...
  87. pmc Doublesex establishes sexual dimorphism in the Drosophila central nervous system in an isoform-dependent manner by directing cell number
    Laura E Sanders
    Sections of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Dev Biol 320:378-90. 2008
    ....
  88. ncbi An elegant miRror: microRNAs in stem cells, developmental timing and cancer
    Rachael A Nimmo
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Chromosoma 118:405-18. 2009
    ....
  89. pmc Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
    Megan F Cole
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 22:746-55. 2008
    ..Our results suggest that the Wnt pathway, through Tcf3, brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation...
  90. ncbi Follicular cells of the thyroid gland require Pax8 gene function
    A Mansouri
    MPI of Biophysical Chemistry, Dept of Molecular Cell Biology, Gottingen, Germany
    Nat Genet 19:87-90. 1998
    ..We present evidence that Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells...
  91. ncbi Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment
    M Crozatier
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 31062 TOULOUSE 04 cedex, France
    Development 126:4385-94. 1999
    ....
  92. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
    ..Different family members have also been implicated in the signalling cascade that confers left right identity, as well as in the formation of appendages, neural differentiation, cell division and cell survival...
  93. ncbi P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction
    Kristin D Kasschau
    Center for Gene Research and Biotechnology and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Dev Cell 4:205-17. 2003
    ..The basis for TuMV- and other virus-induced disease in plants may be explained, at least partly, by interference with miRNA-controlled developmental pathways that share components with the antiviral RNA-silencing pathway...
  94. ncbi Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    W S Chen
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Genes Dev 8:2466-77. 1994
    ..Development of embryonic structures is severely impaired. These results demonstrate that the expression of HNF-4 in the visceral endoderm is essential for embryonic ectoderm survival and normal gastrulation...
  95. pmc Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
    C D Helgason
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genes Dev 12:1610-20. 1998
    ..Thus, homozygous disruption of SHIP establishes the crucial role of this molecule in modulating cytokine signaling within the hemopoietic system and provides a powerful model for further delineating its function...
  96. ncbi FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, 10 Center Drive, National Institutes of Health, Bethesda, MD, USA
    Development 125:3615-23. 1998
    ..These data revealed a cooperative function of FGFR-3 and FGFR-4 to promote the formation of alveoli during postnatal lung development...
  97. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  98. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins...
  99. ncbi Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    Julie K Stock
    Nuclear Organisation, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 9:1428-35. 2007
    ..These observations provide an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes...
  100. ncbi Epigenetic instability in ES cells and cloned mice
    D Humpherys
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA
    Science 293:95-7. 2001
    ..These data imply that even apparently normal cloned animals may have subtle abnormalities in gene expression...
  101. ncbi Genetic control of Drosophila nerve cord development
    James B Skeath
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Curr Opin Neurobiol 13:8-15. 2003
    ..These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter...

Research Grants193 found, 100 shown here

  1. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2003
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  2. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2008
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  3. Egg to Embryo: Gene Regulatory Circuitry in Development
    Eric Davidson; Fiscal Year: 2008
    ..A Research Core Service Facility similar but not identical to the current one is also requested, the basic role of which is to provide embryos, eggs and nuclear extracts of S. purpuratus to the three Research Components. ..
  4. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric H Davidson; Fiscal Year: 2010
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  5. GABAergic Dysfunction in Autism
    S Fatemi; Fiscal Year: 2008
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  6. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2009
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  7. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2004
    ..abstract_text> ..
  8. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  9. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 1991
    ....
  10. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2009
    ..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
  11. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1991
    ....
  12. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2000
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  13. Computational Model of Gene Regulatory Program
    Eric Davidson; Fiscal Year: 2007
    ..abstract_text> ..
  14. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  15. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  16. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2002
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  17. Cellular Interactions During Ear Development
    Bernd Fritzsch; Fiscal Year: 2003
    ..Such information can guide future research on regeneration of these cells in patients suffering sensorineuronal hearing loss and other areas of neuroscience less amenable to such investigations. ..
  18. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2002
    ....
  19. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2002
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  20. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2005
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  21. Prenatal Virally Induced Brain Disorder in Mouse
    S Fatemi; Fiscal Year: 2006
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  22. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2007
    ..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
  23. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2007
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  24. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  25. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2001
    ..abstract_text> ..
  26. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  27. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2009
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  28. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  29. Function of active chromatin domains in erythropoiesis
    MICHAEL D BULGER; Fiscal Year: 2010
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  30. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2009
    ..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..
  31. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  32. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  33. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 1999
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  34. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2009
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  35. COMPUTATIONAL MODEL OF GENE REGULATORY PROGRAM
    Eric Davidson; Fiscal Year: 2002
    ..The model will ultimately constitute a quantitative computational analysis of a genomic regulatory network, defined at the DNA sequence level, the function of which is to organize a complex, major process in animal development. ..
  36. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2002
    ..abstract_text> ..
  37. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  38. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2003
    ..abstract_text> ..
  39. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2003
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  40. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2007
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  41. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2009
    ..Verifying the function of those newly discovered genes in mouse development will greatly enhance our ability to move the already funded R01 project toward translational research. ..
  42. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2006
    ..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..
  43. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2006
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  44. ISOLATION & FUNCTION OF THE XLIS NEURONAL MIGRATION GENE
    Margaret Ross; Fiscal Year: 2003
    ....
  45. Hematopoietic Regulation of GATA Switches
    EMERY BRESNICK; Fiscal Year: 2008
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  46. Hematopoietic Regulation of GATA Switches
    Emery H Bresnick; Fiscal Year: 2010
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  47. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2009
    ..Understanding the genetic organization of the brainstem neurons that generate breathing is essential for the diagnosis and treatment of breathing disorders. ..
  48. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2006
    ..abstract_text> ..
  49. Chromatin remodeling complexes in heart development
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  50. Crooked Tail: Gene Expression in a Neural Tube Defect
    Margaret Ross; Fiscal Year: 2005
    ..abstract_text> ..
  51. Developmental Regulation of MacroH2A1 Chromatin Assembly
    Theodore Rasmussen; Fiscal Year: 2009
    ..Research proposed here will provide basic insights into differentiation biology and provide a framework for future attempts to achieve rationally-guided ES cell differentiation. ..
  52. MECHANISM OF THE HUMAN BETA-GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 2005
    ..The long-term objective is to therapeutically modulate beta-globin gene expression in humans with hemoglobinopathies by perturbing specific steps of the mechanism by which the LCR regulate the beta-globin genes. ..
  53. Pro-inflammatory gene regulation in a native chromatin environment
    STEPHEN SMALE; Fiscal Year: 2009
    ..The long-term goal of this research is to develop strategies for the selective modulation of pro-inflammatory genes in the context of human disease. ..
  54. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2007
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  55. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2005
    ..abstract_text> ..
  56. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..The results obtained will be relevant to human diseases that affect these processes, including arrhythmias after infarct and cardiac remodeling in heart failure. ..
  57. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2006
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  58. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2001
    ..Finally, to examine the relevance of Ikaros for gene inactivation in lymphocytes, mouse strains allowing the conditional disruption of the Ikaros gene are being prepared. ..
  59. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2002
    ..abstract_text> ..
  60. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2001
    ..abstract_text> ..
  61. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2002
    ..Finally, to examine the relevance of Ikaros for gene inactivation in lymphocytes, mouse strains allowing the conditional disruption of the Ikaros gene are being prepared. ..
  62. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2003
    ..Finally, to examine the relevance of Ikaros for gene inactivation in lymphocytes, mouse strains allowing the conditional disruption of the Ikaros gene are being prepared. ..
  63. ISOLATION AND FUNCTION OF THE XLIS NEURONAL MIGRATION
    Margaret Ross; Fiscal Year: 1999
    ....
  64. MECHANISM OF THE HUMAN BETA-GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 2001
    ..The long-term objective is to therapeutically modulate beta-globin gene expression in humans with hemoglobinopathies by perturbing specific steps of the mechanism by which the LCR regulate the beta-globin genes. ..
  65. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2001
    ..abstract_text> ..
  66. Developmental Regulation of MacroH2A1 Chromatin Assembly
    Theodore Rasmussen; Fiscal Year: 2007
    ..Research proposed here will provide basic insights into differentiation biology and provide a framework for future attempts to achieve rationally-guided ES cell differentiation. ..
  67. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2009
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  68. Pro-inflammatory gene regulation in a native chromatin environment
    Stephen T Smale; Fiscal Year: 2010
    ..The long-term goal of this research is to develop strategies for the selective modulation of pro-inflammatory genes in the context of human disease. ..
  69. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2009
    ..abstract_text> ..
  70. ISOLATION & FUNCTION OF THE XLIS NEURONAL MIGRATION GENE
    Margaret Ross; Fiscal Year: 2001
    ....
  71. Hematopoietic Regulation of GATA Switches
    EMERY BRESNICK; Fiscal Year: 2007
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. [unreadable] [unreadable]..
  72. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2009
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  73. Pro-inflammatory gene regulation in a native chromatin environment
    STEPHEN SMALE; Fiscal Year: 2008
    ..The long-term goal of this research is to develop strategies for the selective modulation of pro-inflammatory genes in the context of human disease. ..
  74. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 1999
    ..Eventually, the investigators hope to use the knowledge generated during these studies to elucidate the molecular events that regulate early lymphoid development and the fetal/adult lymphopoietic transition. ..
  75. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2008
    ..abstract_text> ..
  76. Transcriptional Control of Hemoglobin Synthesis
    EMERY BRESNICK; Fiscal Year: 2008
    ..Through the assembly of a database of GRC parameters and computational/statistical analysis, hypotheses regarding determinants of GATA factor occupancy will be tested. ..
  77. MEDICAL SCIENTIST TRAINING PROGRAM
    STEPHEN SMALE; Fiscal Year: 2008
    ....
  78. Selective gene activation by the NF-kappaB family of transcription factors
    STEPHEN SMALE; Fiscal Year: 2008
    ....
  79. ISOLATION & FUNCTION OF THE XLIS NEURONAL MIGRATION GENE
    Margaret Ross; Fiscal Year: 2000
    ....
  80. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2007
    ..abstract_text> ..