Genomes and Genes
developmental gene expression regulation
Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Publications319 found, 100 shown here
- Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cellsH Niwa
Centre for Genome Research, The University of Edinburgh, King s Buildings, Edinburgh, UK
Nat Genet 24:372-6. 2000....
- Genome-wide identification and testing of superior reference genes for transcript normalization in ArabidopsisTomasz Czechowski
Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany
Plant Physiol 139:5-17. 2005..The developed PCR primers or hybridization probes for the novel reference genes will enable better normalization and quantification of transcript levels in Arabidopsis in the future...
- A bivalent chromatin structure marks key developmental genes in embryonic stem cellsBradley E Bernstein
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
Cell 125:315-26. 2006..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
- Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cellsIan Chambers
Institute for Stem Cell Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland
Cell 113:643-55. 2003..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity...
- Core transcriptional regulatory circuitry in human embryonic stem cellsLaurie A Boyer
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Cell 122:947-56. 2005..These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal...
- The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cellsKaoru Mitsui
Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Nara 630 0192, Japan
Cell 113:631-42. 2003..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells...
- Multipotent cell lineages in early mouse development depend on SOX2 functionAriel A Avilion
Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Genes Dev 17:126-40. 2003..5 days postcoitum. Our data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation...
- Identification of novel genes coding for small expressed RNAsM Lagos-Quintana
Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
Science 294:853-8. 2001..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
- Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsTarjei S Mikkelsen
Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Nature 448:553-60. 2007..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
- Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegansColeen T Murphy
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
Nature 424:277-83. 2003....
- Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAsAntonio J Giraldez
Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Science 312:75-9. 2006..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis...
- An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegansN C Lau
Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 294:858-62. 2001..The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals...
- Stability and flexibility of epigenetic gene regulation in mammalian developmentWolf Reik
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
Nature 447:425-32. 2007..It is not known whether any of the epigenetic marks has a primary role in determining cell and lineage commitment during development...
- Osf2/Cbfa1: a transcriptional activator of osteoblast differentiationP Ducy
Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
Cell 89:747-54. 1997..This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation...
- p63 is a p53 homologue required for limb and epidermal morphogenesisA A Mills
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 398:708-13. 1999..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
- Polycomb complexes repress developmental regulators in murine embryonic stem cellsLaurie A Boyer
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 441:349-53. 2006..Our results indicate that dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development...
- SOX2 functions to maintain neural progenitor identityVictoria Graham
Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Neuron 39:749-65. 2003..Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells...
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansB J Reinhart
Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
Nature 403:901-6. 2000..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
- p53 activation by knockdown technologiesMara E Robu
University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS Genet 3:e78. 2007..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies...
- Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiationHitoshi Niwa
Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minamimachi, Kobe, Hyogo 650 0047, Japan
Cell 123:917-29. 2005..This suggests that reciprocal inhibition between lineage-specific transcription factors might be involved in the first differentiation event of mammalian development...
- Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprintingMasahiro Kaneda
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
Nature 429:900-3. 2004..These results indicate that both Dnmt3a and Dnmt3L are required for methylation of most imprinted loci in germ cells, but also suggest the involvement of other factors...
- An extensive class of small RNAs in Caenorhabditis elegansR C Lee
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Science 294:862-4. 2001..elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse...
- Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural developmentT Lee
Department of Cell and Structural Biology, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
Trends Neurosci 24:251-4. 2001....
- Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiationR Dasgupta
Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
Development 126:4557-68. 1999..Furthermore, our findings unveil the importance of activated LEF/TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place...
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene functionC Chiang
Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
Nature 383:407-13. 1996..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
- The snail superfamily of zinc-finger transcription factorsM Angela Nieto
Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
Nat Rev Mol Cell Biol 3:155-66. 2002..Different family members have also been implicated in the signalling cascade that confers left right identity, as well as in the formation of appendages, neural differentiation, cell division and cell survival...
- A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafishKoichi Kawakami
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Dev Cell 7:133-44. 2004..We propose our gene trap approach should facilitate studies of vertebrate development and organogenesis...
- Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathwayClaire Chazaud
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G1X5, Canada
Dev Cell 10:615-24. 2006..We propose a model in which the ICM develops as a mosaic of EPI and PE progenitors at E3.5, dependent on Grb2-Ras-MAP kinase signaling, followed by later segregation of the progenitors into the appropriate cell layers...
- The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6Haruhiko Akiyama
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 16:2813-28. 2002..We conclude that Sox9 is required during sequential steps of the chondrocyte differentiation pathway...
- Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heartChen Leng Cai
Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Dev Cell 5:877-89. 2003..Our results have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells...
- An optimized grapevine RNA isolation procedure and statistical determination of reference genes for real-time RT-PCR during berry developmentKaren E Reid
Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
BMC Plant Biol 6:27. 2006..Few statistically validated reference genes have been reported in grapevine. Moreover, success in isolating high quality RNA from grapevine tissues is typically limiting due to low pH, and high polyphenolic and polysaccharide contents...
- Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAsJohn L Rinn
Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 129:1311-23. 2007..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states...
- Control of developmental regulators by Polycomb in human embryonic stem cellsTong Ihn Lee
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 125:301-13. 2006..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
- Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseShigemi Hayashi
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Dev Biol 244:305-18. 2002..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
- Proneural genes and the specification of neural cell typesNicolas Bertrand
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
Nat Rev Neurosci 3:517-30. 2002..These studies reveal that, in spite of differences between invertebrate and vertebrate neural lineages, Drosophila and vertebrate proneural genes have remarkably similar roles...
- Dynamic reprogramming of DNA methylation in the early mouse embryoFatima Santos
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
Dev Biol 241:172-82. 2002..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...
- Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic statesKatsuhiko Hayashi
Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Cell Stem Cell 3:391-401. 2008....
- Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cellsEran Meshorer
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Cell 10:105-16. 2006....
- Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristemK F Mayer
Lehrstuhl für Entwicklungsgenetik, Universitat Tubingen, Federal Republic of Germany
Cell 95:805-15. 1998....
- Vertebrate neurogenesis is counteracted by Sox1-3 activityMagdalena Bylund
Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
Nat Neurosci 6:1162-8. 2003..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
- Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteinsLeonie Ringrose
ZMBH, University of Heidelberg, 69120 Heidelberg, Germany
Annu Rev Genet 38:413-43. 2004..Here we review current ideas on the protein and DNA components of this transcriptional memory system and how they interact dynamically with each other to orchestrate cellular memory for several hundred genes...
- bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in DrosophilaJulius Brennecke
European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
Cell 113:25-36. 2003..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
- Controlling morpholino experiments: don't stop making antisenseJudith S Eisen
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Development 135:1735-43. 2008..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
- DNA methylation patterns and epigenetic memoryAdrian Bird
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Genes Dev 16:6-21. 2002
- Oct4 is required for primordial germ cell survivalJames Kehler
Germline Development, Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, University of Pennsylvania, 382 W Street Road, Kennett Square, Pennsylvania 19348, USA
EMBO Rep 5:1078-83. 2004..These new results suggest a previously unknown function of Oct4 in maintaining viability of mammalian germline...
- Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in DrosophilaTomoatsu Ikeya
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Biol 12:1293-300. 2002....
- MicroRNA function in animal developmentErno Wienholds
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
FEBS Lett 579:5911-22. 2005..Here, we review the recent advances in miRNA biology in animals. Particularly, we focus on the roles of miRNAs in vertebrate development and disease...
- Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumorsSilvia Maretto
Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
Proc Natl Acad Sci U S A 100:3299-304. 2003..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
- The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionA Cano
Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
Nat Cell Biol 2:76-83. 2000..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
- Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4J Nichols
Centre for Genome Research, University of Edinburgh, United Kingdom
Cell 95:379-91. 1998..Expansion of trophoblast precursors is restored, however, by an Oct4 target gene product, fibroblast growth factor-4. Therefore, Oct4 also determines paracrine growth factor signaling from stem cells to the trophectoderm...
- Oct-4: gatekeeper in the beginnings of mammalian developmentM Pesce
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell' Immacolata, Rome, Italy
Stem Cells 19:271-8. 2001..These novel advances along with latest findings on Oct-4-associated factors, target genes, and dimerization ability, provide new insights into the understanding of the early steps regulating mammalian embryogenesis...
- Wnt signaling: a common theme in animal developmentK M Cadigan
Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
Genes Dev 11:3286-305. 1997
- salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell linesNicolas Tapon
Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown 02129, USA
Cell 110:467-78. 2002..The human ortholog of salvador (hWW45) is mutated in three cancer cell lines. Thus, salvador restricts cell numbers in vivo by functioning as a dual regulator of cell proliferation and apoptosis...
- The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell massNoriyuki Nishioka
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
Dev Cell 16:398-410. 2009..Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation...
- Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAsRui Yi
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
Nat Genet 38:356-62. 2006..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ...
- A heterogeneous expression pattern for Nanog in embryonic stem cellsAmar M Singh
Department of Pathology, University of Florida College of Medicine, Box 100275, Gainesville, Florida 32610, USA
Stem Cells 25:2534-42. 2007..Disclosure of potential conflicts of interest is found at the end of this article...
- Wnt/beta-catenin signaling in development and diseaseHans Clevers
Hubrecht Laboratory and Utrecht University, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
Cell 127:469-80. 2006..Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues...
- Identification of genes required for embryo development in ArabidopsisIris Tzafrir
Department of Botany, Oklahoma State University, Stillwater, Oklahoma 74078, USA
Plant Physiol 135:1206-20. 2004..These candidates should facilitate the recovery of additional genes required for seed development...
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional networkEric Dessaud
Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Development 135:2489-503. 2008..We discuss recent advances in our understanding of these events and highlight unresolved questions...
- Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesBrian D Harfe
Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
Cell 118:517-28. 2004..Genetic studies of the effects of limiting accessibility of Shh within the limb support this model, in which the effect of the Shh morphogen is dictated by a temporal as well as a spatial gradient...
- Placental development: lessons from mouse mutantsJ Rossant
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
Nat Rev Genet 2:538-48. 2001..Furthering our understanding of mouse trophoblast development should provide novel insights into human placental function...
- Retinoid signaling determines germ cell fate in miceJosephine Bowles
Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
Science 312:596-600. 2006..Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate...
- Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous systemSteven W Flavell
F M Kirby Neurobiology Center, Children s Hospital Boston, and Departments of Neurology and Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Neurosci 31:563-90. 2008....
- Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genesMilo J Aukerman
E I duPont de Nemours and Company, Agriculture and Nutrition, Newark, Delaware 19711, USA
Plant Cell 15:2730-41. 2003..Gain-of-function and loss-of-function analyses indicate that two of the AP2-like target genes normally act as floral repressors, supporting the notion that miR172 regulates flowering time by downregulating AP2-like target genes...
- Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAA E Pasquinelli
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Nature 408:86-9. 2000..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
- Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of FrizzledT Usui
Department of Biophysics, Faculty of Science, Japan
Cell 98:585-95. 1999..These results, together with phenotypes caused by ectopic expression of fz and fmi, suggest that cells acquire the P-D polarity by way of the Fz-dependent boundary localization of Fmi...
- WNT signals are required for the initiation of hair follicle developmentThomas Andl
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 2:643-53. 2002..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
- Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cellsPaul Gadue
Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1496, New York, NY 10029, USA
Proc Natl Acad Sci U S A 103:16806-11. 2006....
- Genome regulation by polycomb and trithorax proteinsBernd Schuettengruber
Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
Cell 128:735-45. 2007..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
- The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNAE G Moss
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Cell 88:637-46. 1997..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
- Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancerRyohei Sekido
Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 453:930-4. 2008..Our results open up the field, permitting further characterization of the molecular mechanisms regulating sex determination and how they have evolved, as well as how they fail in cases of sex reversal...
- Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cellsMegan F Cole
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genes Dev 22:746-55. 2008..Our results suggest that the Wnt pathway, through Tcf3, brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation...
- Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous systemM Maduro
Department of Biological Sciences, University of Alberta, Edmonton, Canada
Genetics 141:977-88. 1995..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system...
- The graded response to Sonic Hedgehog depends on cilia architectureTamara Caspary
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Dev Cell 12:767-78. 2007..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
- Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesisP Carmeliet
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
Cell 98:147-57. 1999..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
- RAS is regulated by the let-7 microRNA familySteven M Johnson
Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
Cell 120:635-47. 2005..let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer...
- TRANSFAC: transcriptional regulation, from patterns to profilesV Matys
BIOBASE GmbH, Halchtersche Strasse 33, D 38304 Wolfenbuttel, Germany
Nucleic Acids Res 31:374-8. 2003..gbf.de. For CYTOMER free download versions are available at http://www.biobase.de:8080/index.html...
- Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsT Komori
Department of Medicine III, Osaka University Medical School, Suita, Japan
Cell 89:755-64. 1997....
- Zac1 regulates an imprinted gene network critically involved in the control of embryonic growthAnnie Varrault
Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
Dev Cell 11:711-22. 2006..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
- Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylationShaun D Fouse
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Stem Cell 2:160-9. 2008..Our data suggest that in mES cells promoter methylation represents a unique epigenetic program that complements other regulatory mechanisms to ensure appropriate gene expression...
- p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentA Yang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 398:714-8. 1999..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis...
- Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cellsTakaki Miyata
Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Saitama 351 0198, Japan
Development 131:3133-45. 2004..The asymmetric P/P division may therefore contribute to efficient neuron/progenitor segregation required for CP initiation through cell cycle-dependent and lineage-restricted expression of Ngn2...
- The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationKazuhisa Nakashima
Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cell 108:17-29. 2002..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
- Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain developmentY Furuta
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
Development 124:2203-12. 1997..These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death...
- The transcriptome profile of human embryonic stem cells as defined by SAGEMark Richards
Department of Obstetrics and Gynecology, National University of Singapore, National University Hospital, Singapore
Stem Cells 22:51-64. 2004....
- Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesisYong Zhao
Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Nature 436:214-20. 2005..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
- A nutrient sensor mechanism controls Drosophila growthJulien Colombani
Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
Cell 114:739-49. 2003..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
- Making or breaking the heart: from lineage determination to morphogenesisDeepak Srivastava
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
Cell 126:1037-48. 2006....
- Prediction of plant microRNA targetsMatthew W Rhoades
Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
Cell 110:513-20. 2002..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages...
- Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two speciesAnnie Rochette
Research Centre in Infectious Diseases, CHUL Research Centre and Department of Medical Biology, Faculty of Medicine, Laval University, Quebec, Canada
BMC Genomics 9:255. 2008....
- Math1: an essential gene for the generation of inner ear hair cellsN A Bermingham
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Science 284:1837-41. 1999..Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells...
- Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genesMichael Korenjak
Lehrstuhl für Molekularbiologie, Adolf Butenandt Institut, Ludwig Maximilians Universitat, Munchen, Germany
Cell 119:181-93. 2004..These results reveal an extensive evolutionary conservation of specific pRb repressor complexes that physically combine subunits with established roles in the regulation of transcription, DNA replication, and chromatin structure...
- Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivoY Y Kisanuki
Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
Dev Biol 230:230-42. 2001..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
- Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brainAnna L M Ferri
Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Development 131:3805-19. 2004..These findings highlight a crucial and unexpected role for Sox2 in the maintenance of neurones in selected brain areas, and suggest a contribution of neural cell proliferative defects to the pathological phenotype...
- T-box genes in vertebrate developmentL A Naiche
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Annu Rev Genet 39:219-39. 2005..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
- The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cellsTaeko Kobayashi
Institute for Virus Research, Kyoto University, Kyoto, Japan
Genes Dev 23:1870-5. 2009..Thus, Hes1-null ES cells display less heterogeneity in both the differentiation timing and fate choice, suggesting that the cyclic gene Hes1 contributes to heterogeneous responses of ES cells even under the same environmental conditions...
- Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytesToshiaki Watanabe
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
Nature 453:539-43. 2008..Our results reveal a role for endogenous siRNAs in mammalian oocytes and show that organisms lacking RdRP activity can produce functional endogenous siRNAs from naturally occurring dsRNAs...
- Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryosQinghua Tao
Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
Cell 120:857-71. 2005..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
- A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle developmentThomas Sandmann
European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
Dev Cell 10:797-807. 2006..The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated...
- Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1Jeremy S Dasen
Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
Cell 134:304-16. 2008..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map...
- Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinaseP S Danielian
Department of Molecular and Cellular Biology Harvard University 16 Divinity Avenue, Cambridge Massachusetts 02138 USA
Curr Biol 8:1323-6. 1998..Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo...
- Vernalization a cold-induced regulatory network establishing cellular memoryRichard M Amasino; Fiscal Year: 2010..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
- DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.Bernd Fritzsch; Fiscal Year: 2010..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..
- Regulatory Genomics: BAC-GFP Library of Control GenesEric Davidson; Fiscal Year: 2008..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
- MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITYTheodore Slotkin; Fiscal Year: 2004..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
- Fetal & Adolescent Nicotine Effects on CNS 5HT SystemsTheodore Slotkin; Fiscal Year: 2003..abstract_text> ..
- Varenicline and Smoking Cessation in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
- DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEMTheodore Slotkin; Fiscal Year: 2003....
- Prenatal Virally Induced Brain Disorder in MouseSEYYED FATEMI; Fiscal Year: 2009..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
- METHODS FOR ANALYSIS OF GENE FUNCTION IN NEURAL NETWORKSHoward Federoff; Fiscal Year: 2002..4) Bioinformatics methods to extract genetic regulatory networks from mined profile data. ..
- FUNCTIONAL GENOMICS OF THE BETA-CELLKLAUS KAESTNER; Fiscal Year: 2007..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
- Spiralian developmental system for the study of multipotencyCesar Arenas Mena; Fiscal Year: 2008..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
- Inaugural conference on Integrative PhysiologyGerard Karsenty; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol ExposureROBERT KRAUSS; Fiscal Year: 2008..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
- Cadherin regulation of tissue polarity and growthMichael Simon; Fiscal Year: 2007..unreadable] [unreadable]..
- Development of C57BL/6 ES cell technology for high thoughput use.KLAUS KAESTNER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- In vitro culture and transformation of Wolbachia from mosquitoesAnn Fallon; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DEVELOPMENT OF OLFACTORY CONNECTIONSQizhi Gong; Fiscal Year: 2007..abstract_text> ..
- Role of cdx genes and RA in regionalizing the endodermMARY KINKEL; Fiscal Year: 2007..Finally, I will investigate the role of RA signaling in regulating Cdx genes utilizing loss-of-function approaches as well as treatment with exogenous RA. ..
- Dendritic Cell-Specific Gene Targeting and ExpressionBoris Reizis; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanisms of TGFB Signal TransductionAkiko Hata; Fiscal Year: 2007..These studies should provide important insights into TGFbeta-mediated regulation of gene expression, which is of direct relevance to both normal physiology and a variety of disease states. ..
- Functional genomics of molluscan schistosome developmentTIMOTHY YOSHINO; Fiscal Year: 2009..Results of this work may lead to novel strategies for controlling infections within the snail host by disrupting specific larval development-dependent genes or their products. ..
- Role of BMPRII Mutants in the Pathogenesis of Pulmonary HypertensionAkiko Hata; Fiscal Year: 2009....
- ENHANCED TISSUE REGENERATION OF OROFACIAL MUSCLESGRACE PAVLATH; Fiscal Year: 2002....
- Molecular Studies of Immunoparasitology in SnailsSi Ming Zhang; Fiscal Year: 2010..This may lead to new methods for blocking the transmission of Schistosomiasis, a snail-borne disease that affects 200 million people worldwide. ..
- ROLES OF SOX C GENES IN SKELETOGENESISVERONIQUE M LEFEBVRE; Fiscal Year: 2010....
- Molecular Genetics of Carney ComplexCathy J Hatcher; Fiscal Year: 2010....
- Genome-wide discovery of beta cell gene control elementsClaudia Kappen; Fiscal Year: 2004..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
- Mechanisms of NeurodegenerationRoger J Davis; Fiscal Year: 2010..The Specific Aims of this proposal are to examine: 1. The physiological role of JNK in neurons. 2. The mechanism of JNK-induced neurodegeneration. ..
- Nectin-1: Synaptic processing and functionsHoward J Federoff; Fiscal Year: 2010..Subsequently, we examine whether expression of trans-dominant nectin-1 mutants will affect hippocampal dependent learning ..
- RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTHROBERT KRAUSS; Fiscal Year: 2002..Such genes represent potential mediators of the transformed phenotype. ..
- The Physiology of Radial Units in CorticogenesisArnold Kriegstein; Fiscal Year: 2010..The results of this study may help shed light on mechanisms relevant to the etiology of many of them. ..
- Genetic Analysis of Germ Cell FormationRenee Reijo Pera; Fiscal Year: 2009..As such, this research is significant to our understanding of basic germ cell development in humans and has the direct potential to increase knowledge of germ cell defects in the 10-15% of couples who are infertile. ..
- Nucleotide polymorphisms responsible for expression variation in DrosophilaSergey Nuzhdin; Fiscal Year: 2009..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..
- Recovery of functional p53 as a therapeutic approach for breast cancerSALMAN HYDER; Fiscal Year: 2008..Furthermore, we contend that the research will provide critical data relevant to minimizing breast cancer risk and metastasis in post-menopausal women and other women exposed to exogenous progestins. ..
- MOLECULAR GENETICS OF THERMOGENESISLESLIE KOZAK; Fiscal Year: 2007..Concurrent with gene identification, the experiments will provide phenotypic information on how these genes affect the development of excessive adiposity. ..
- ENVIRONMENTAL NEUROTOXICANT GENETIC ACTION--MURINE MODELHoward Federoff; Fiscal Year: 2002....
- Notch Signaling in the Adult, Aging and Diseased BrainPasko Rakic; Fiscal Year: 2005..abstract_text> ..
- Transcriptional Control of Hematopoietic Stem CellsEMERY BRESNICK; Fiscal Year: 2005..The studies will define the regulation and function of GATA-2 as a prelude to developing principles for how chromatin domains and transcriptional networks assemble in and control HSCs. ..
- Regulation Trigeminal Neuron Differentiation&ProjectionQiufu Ma; Fiscal Year: 2005..These sublineage-specific genes will be candidate molecules that control cell subtype specification. ..
- RENIN CELL FATE IN THE KIDNEY VASCULATURERoberto Gomez; Fiscal Year: 2005..The studies should generate fundamental new knowledge on JG cell differentiation and function and open new avenues for the understanding, prevention and treatment of hypertension and kidney diseases. ..
- 2004 Mechanisms of Toxicity Gordon Research ConferenceKenneth Ramos; Fiscal Year: 2004..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
- CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASESMichael Simon; Fiscal Year: 2004..abstract_text> ..
- SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDSROBERT CHAPKIN; Fiscal Year: 2003..g., rheumatoid arthritis), without compromising host defenses. ..
- UCI-CFC Projects on School ReadinessJames Swanson; Fiscal Year: 2002....
- Web-Based System for Research Protocol SubmissionRoberto Gomez; Fiscal Year: 2003..We will try to reach small institutions by annoucements and demonstrations at local, regional and national meetings of the Society for Research Administration, International. ..
- CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..
- POSITIONAL CLONING OF A GENE FOR ESSENTIAL TREMORJoseph Higgins; Fiscal Year: 2004..abstract_text> ..
- Cell Interactions in Synapes Formation and FunctionJuan Bruses; Fiscal Year: 2005....
- ROCHESTER NATHAN SHOCK CENTERHoward Federoff; Fiscal Year: 2004..abstract_text> ..
- Control of IGF-I Gene Transcription in OsteoblastsPeter Rotwein; Fiscal Year: 2007..3. To define mechanisms of termination of hormone-activated IGF-I transcription and down regulation of C/EBPdelta activity in osteoblasts. 4. To evaluate by gene profiling the role of C/EBPdelta in osteoblast biology. ..
- Coactivators that Mediate Beta-Globin LCR FunctionEMERY BRESNICK; Fiscal Year: 2006..The long-term objective is to therapeutically control beta-globin genes in humans with hemoglobinopathies by regulating specific steps of the LCR mechanism. ..
- Differentiation of ES Cells into Renal EpitheliaGregory Dressler; Fiscal Year: 2006..Since ES cells potentially represent an unlimited supply of renal progenitors, these experiments will lay the foundation for cell based therapies to improve the efficacy of ATN treatment. ..
- Parkinson's Disease Gene Therapy Study GroupHoward Federoff; Fiscal Year: 2006..Focus 5: Development of a hioethics approach to PD gene therapy. PP VIII. "Measuring and Explaining PD Patients' Participation Preferences Regarding Phase I Studies in Gene Transfer Therapy" (PI: Kim). ..
- Co-stimulatory Regulation of Immune Function & ToleranceChen Dong; Fiscal Year: 2006..These studies will advance our knowledge of the regulation of T-cell function and tolerance, and may lead to a greater understanding of autoimmune diseases. ..
- Individual Differences in Mesolimbic Dopamine SystemsMichael Meaney; Fiscal Year: 2003..We feel that these studies will provide us with an understanding of the way in which early environmental events might contribute to the development of individual differences in neural systems that mediate drug-seeking behavior. ..
- ISOLATION & FUNCTION OF THE XLIS NEURONAL MIGRATION GENEMargaret Ross; Fiscal Year: 2003....
- Chromatin remodeling complexes in heart developmentBENOIT GAETAN BRUNEAU; Fiscal Year: 2010..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
- Developmental Regulation of MacroH2A1 Chromatin AssemblyTheodore Rasmussen; Fiscal Year: 2009..Research proposed here will provide basic insights into differentiation biology and provide a framework for future attempts to achieve rationally-guided ES cell differentiation. ..
- Iroquois Homeobox Transcription Factors in Heart Development and PhysiologyBENOIT GAETAN BRUNEAU; Fiscal Year: 2010..The results obtained will be relevant to human diseases that affect these processes, including arrhythmias after infarct and cardiac remodeling in heart failure. ..
- Genetic Predisposition & Prevention of Neural Tube Defects (NTDs)MARGARET ELIZABETH contact ROSS; Fiscal Year: 2010..This will begin to reveal mechanisms by which FA, and inositol, acts to suppress NTD. ..
- Regulation of Cellular Senescence by MEG3 RNAYunli Zhou; Fiscal Year: 2007..Therefore, another specific aim is to determine how MEGS activates p53. Whether MEG3 RNA activates p53 through repression of Mdm2 expression will be the focus of investigation. [unreadable] [unreadable] [unreadable] [unreadable]..
- Hemichordartes and the Origin of ChordatesJohn Gerhart; Fiscal Year: 2009..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
- Early Chronic Stress and Prefrontal DevelopmentDavid Lyons; Fiscal Year: 2005..abstract_text> ..
- SIGNAL TRANSDUCTION BY THE EGF RECEPTORRoger Davis; Fiscal Year: 2001..In the second aim, the investigator will attempt to identify target molecules that interact with ZPR1. In the third specific aim, the investigator will determine ZPR1 function using genetic analysis in yeast. ..
- Functional Analysis of the Beta-CellRoger Davis; Fiscal Year: 2006..The Specific Aims of this proposal are to employ mouse models to: Define the role of JNK in beta cells. Define the role of JIP scaffold proteins in beta cells Define the function of diabetes-associated mutations in JIP1 ..
- GENETIC INTERACTIONS IN ATHEROSCLEROSIS AND HYPERTENSIONNobuyo Maeda; Fiscal Year: 2002..Better understanding of the effects on atherogenesis of the individual factors that affect blood pressures should help the development of new means for prevention and treatment of cardiovascular diseases. ..
- Molecular mechanism of ADNF and ADNP peptides in neuroprotection to alcoholYoussef Sari; Fiscal Year: 2008..This data will shed light on the mechanisms governing brain ontogeny and will pave the path toward potential therapeutics against developmental insults associated with prenatal alcohol exposure. [unreadable] [unreadable] [unreadable]..
- STRUCTURAL ORGANIZATION OF SIGNALING PATHWAYSRoger Davis; Fiscal Year: 2004..The Specific Aims of this proposal are to examine: 1. The physiological role of JIP scaffold proteins. 2. The structure and dynamics of JIP scaffold complexes. 3. The mechanism of JIP-stimulated JNK activity. ..
- DEVELOPMENTAL REGULATION OF O2 SENSING IN THE LUNGDavid Cornfield; Fiscal Year: 2009..The strategy of modulating BKCa channel subunit expression to enhance pulmonary vasodilation may be more broadly applicable to other vascular diseases. ..
- Adaptive evolution of pathogenesis towards symbiosisSerap Aksoy; Fiscal Year: 2009..The role of functions typically associated with pathogenic microorganisms will be pursued in these beneficial microbes. ..