developmental gene expression regulation

Summary

Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Top Publications

  1. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:781-92. 2001
  2. ncbi Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice
    Luca Muzio
    Department of Biological and Technological Research (DIBIT, Istituto Scientifico H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Nat Neurosci 5:737-45. 2002
  3. ncbi Expression of NK2 homologous transcripts during zebrafish development
    J Wanga
    Department of Biology, Howard University, Washington, DC 20059, USA
    J Submicrosc Cytol Pathol 34:233-9. 2002
  4. ncbi Ectopic Pax6 expression disturbs lens fiber cell differentiation
    Melinda K Duncan
    Department of Biological Sciences, University of Delaware, Newark, Delaware, USA
    Invest Ophthalmol Vis Sci 45:3589-98. 2004
  5. ncbi Transcriptional activation by extradenticle in the Drosophila visceral mesoderm
    Brian G Stultz
    Cellular and Tissue Therapy Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 730, Bldg 29B, Rm 1E16, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Dev Biol 290:482-94. 2006
  6. ncbi Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
  7. ncbi Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
  8. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
  9. ncbi Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
    Tomasz Czechowski
    Max-Planck Institute of Molecular Plant Physiology, Potsdam, Germany
    Plant Physiol 139:5-17. 2005
  10. ncbi DNA methylation patterns and epigenetic memory
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Genes Dev 16:6-21. 2002

Research Grants

  1. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric H Davidson; Fiscal Year: 2010
  2. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2004
  3. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
  4. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2009
  5. Computational Model of Gene Regulatory Program
    Eric Davidson; Fiscal Year: 2007
  6. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
  7. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
  8. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2005
  9. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2007
  10. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009

Detail Information

Publications247 found, 100 shown here

  1. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis...
  2. ncbi Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice
    Luca Muzio
    Department of Biological and Technological Research (DIBIT, Istituto Scientifico H. San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Nat Neurosci 5:737-45. 2002
    ....
  3. ncbi Expression of NK2 homologous transcripts during zebrafish development
    J Wanga
    Department of Biology, Howard University, Washington, DC 20059, USA
    J Submicrosc Cytol Pathol 34:233-9. 2002
    ..By 72 hpf, NK2 transcripts appeared in the jaw bones, pharyngeal arches, the cranium with minimal expression in striated muscle...
  4. ncbi Ectopic Pax6 expression disturbs lens fiber cell differentiation
    Melinda K Duncan
    Department of Biological Sciences, University of Delaware, Newark, Delaware, USA
    Invest Ophthalmol Vis Sci 45:3589-98. 2004
    ..This study is to test the hypothesis that normal fiber cell differentiation would be perturbed by sustained Pax6 expression...
  5. ncbi Transcriptional activation by extradenticle in the Drosophila visceral mesoderm
    Brian G Stultz
    Cellular and Tissue Therapy Branch, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM 730, Bldg 29B, Rm 1E16, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Dev Biol 290:482-94. 2006
    ..We demonstrate that nuclear EXD is more extensively phosphorylated than the cytoplasmic form, suggesting that EXD is a target of signal transduction by protein kinases...
  6. ncbi Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    Tarjei S Mikkelsen
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
    Nature 448:553-60. 2007
    ..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
  7. ncbi Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
    John L Rinn
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 129:1311-23. 2007
    ..Thus, transcription of ncRNA may demarcate chromosomal domains of gene silencing at a distance; these results have broad implications for gene regulation in development and disease states...
  8. ncbi A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
  9. ncbi Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis
    Tomasz Czechowski
    Max-Planck Institute of Molecular Plant Physiology, Potsdam, Germany
    Plant Physiol 139:5-17. 2005
    ..The developed PCR primers or hybridization probes for the novel reference genes will enable better normalization and quantification of transcript levels in Arabidopsis in the future...
  10. ncbi DNA methylation patterns and epigenetic memory
    Adrian Bird
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Genes Dev 16:6-21. 2002
  11. ncbi Wnt/beta-catenin signaling in development and disease
    Hans Clevers
    Hubrecht Laboratory and Utrecht University, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
    Cell 127:469-80. 2006
    ..Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues...
  12. ncbi Core transcriptional regulatory circuitry in human embryonic stem cells
    Laurie A Boyer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 122:947-56. 2005
    ..These results provide new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal...
  13. ncbi RAS is regulated by the let-7 microRNA family
    Steven M Johnson
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 120:635-47. 2005
    ..let-7 expression is lower in lung tumors than in normal lung tissue, while RAS protein is significantly higher in lung tumors, providing a possible mechanism for let-7 in cancer...
  14. ncbi Prediction of plant microRNA targets
    Matthew W Rhoades
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, MA 02142, USA
    Cell 110:513-20. 2002
    ..The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages...
  15. ncbi Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 453:930-4. 2008
    ..Our results open up the field, permitting further characterization of the molecular mechanisms regulating sex determination and how they have evolved, as well as how they fail in cases of sex reversal...
  16. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  17. ncbi A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    G Hutvagner
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 293:834-8. 2001
    ..Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA-processing enzyme Dicer to produce the active small-RNA component that represses gene expression...
  18. ncbi Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
    P S Danielian
    Department of Molecular and Cellular Biology Harvard University 16 Divinity Avenue, Cambridge Massachusetts 02138 USA
    Curr Biol 8:1323-6. 1998
    ..Induction was ligand dependent, rapid and efficient. The results demonstrate that tamoxifen-inducible recombination can be used to effectively modify gene function in the mouse embryo...
  19. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
    ..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
  20. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-2200, USA
    Nature 424:277-83. 2003
    ....
  21. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ....
  22. ncbi Control of developmental regulators by Polycomb in human embryonic stem cells
    Tong Ihn Lee
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 125:301-13. 2006
    ..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
  23. ncbi Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  24. ncbi Various spatiotemporal expression profiles of anther-expressed genes in rice
    Tokunori Hobo
    Bioscience and Biotechnology Center, Nagoya University, Furocho, Chikusa, Nagoya, 464 8601 Japan
    Plant Cell Physiol 49:1417-28. 2008
    ....
  25. ncbi Controlling morpholino experiments: don't stop making antisense
    Judith S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 135:1735-43. 2008
    ..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
  26. ncbi MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  27. ncbi Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system
    Steven W Flavell
    F M Kirby Neurobiology Center, Children s Hospital Boston, and Departments of Neurology and Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Neurosci 31:563-90. 2008
    ....
  28. ncbi A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  29. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  30. ncbi Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
    Paul Gadue
    Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, 1 Gustave Levy Place, Box 1496, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 103:16806-11. 2006
    ....
  31. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
    ..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
  32. ncbi Identification of genes required for embryo development in Arabidopsis
    Iris Tzafrir
    Department of Botany, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Plant Physiol 135:1206-20. 2004
    ..These candidates should facilitate the recovery of additional genes required for seed development...
  33. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
  34. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ....
  35. ncbi Genome regulation by polycomb and trithorax proteins
    Bernd Schuettengruber
    Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Cell 128:735-45. 2007
    ..Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery...
  36. ncbi p63 is a p53 homologue required for limb and epidermal morphogenesis
    A A Mills
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 398:708-13. 1999
    ..Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis...
  37. ncbi The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis
    Jeong Hoe Kim
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant J 36:94-104. 2003
    ..These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues...
  38. ncbi Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control
    R Gualdi
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Genes Dev 10:1670-82. 1996
    ..The findings also provide insight into the evolutionary origin of different endodermal cell types...
  39. ncbi Multipotent cell lineages in early mouse development depend on SOX2 function
    Ariel A Avilion
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 17:126-40. 2003
    ..5 days postcoitum. Our data suggest that maternal components could be involved in establishing early cell fate decisions and that a combinatorial code, requiring SOX2 and OCT4, specifies the first three lineages present at implantation...
  40. ncbi Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis
    Ruth Diez del Corral
    Division of Cell and Developmental Biology, Life Sciences Faculty, University of Dundee, UK
    Bioessays 26:857-69. 2004
    ....
  41. ncbi Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    Nataliya Libina
    Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 115:489-502. 2003
    ..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
  42. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..This study identifies Osf2/Cbfa1 as an osteoblast-specific transcription factor and as a regulator of osteoblast differentiation...
  43. ncbi Targeted mutagenesis of Tsix leads to nonrandom X inactivation
    J T Lee
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02115, USA
    Cell 99:47-57. 1999
    ..Therefore, counting, choice, and silencing are genetically separable. Contrasting effects in XX and XY cells argue that negative and positive factors are involved in choosing active and inactive Xs...
  44. ncbi Doublesex establishes sexual dimorphism in the Drosophila central nervous system in an isoform-dependent manner by directing cell number
    Laura E Sanders
    Sections of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Dev Biol 320:378-90. 2008
    ....
  45. ncbi Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells
    Megan F Cole
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genes Dev 22:746-55. 2008
    ..Our results suggest that the Wnt pathway, through Tcf3, brings developmental signals directly to the core regulatory circuitry of ES cells to influence the balance between pluripotency and differentiation...
  46. ncbi P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction
    Kristin D Kasschau
    Center for Gene Research and Biotechnology and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA
    Dev Cell 4:205-17. 2003
    ..The basis for TuMV- and other virus-induced disease in plants may be explained, at least partly, by interference with miRNA-controlled developmental pathways that share components with the antiviral RNA-silencing pathway...
  47. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  48. ncbi Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
    Shigemi Hayashi
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 244:305-18. 2002
    ..This inducible Cre system will be a broadly useful tool to modulate gene activity in mouse embryos, adults, and culture systems where temporal control is an important consideration...
  49. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
    ..Different family members have also been implicated in the signalling cascade that confers left right identity, as well as in the formation of appendages, neural differentiation, cell division and cell survival...
  50. ncbi Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment
    M Crozatier
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 31062 TOULOUSE 04 cedex, France
    Development 126:4385-94. 1999
    ....
  51. ncbi Follicular cells of the thyroid gland require Pax8 gene function
    A Mansouri
    MPI of Biophysical Chemistry, Dept of Molecular Cell Biology, Gottingen, Germany
    Nat Genet 19:87-90. 1998
    ..We present evidence that Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells...
  52. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis...
  53. ncbi An elegant miRror: microRNAs in stem cells, developmental timing and cancer
    Rachael A Nimmo
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Chromosoma 118:405-18. 2009
    ....
  54. ncbi Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    W S Chen
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Genes Dev 8:2466-77. 1994
    ..Development of embryonic structures is severely impaired. These results demonstrate that the expression of HNF-4 in the visceral endoderm is essential for embryonic ectoderm survival and normal gastrulation...
  55. ncbi Medaka vasa is required for migration but not survival of primordial germ cells
    Mingyou Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan, China
    Mech Dev 126:366-81. 2009
    ..Taken together, medaka vasa is cell-autonomously required for PGC migration, but dispensable to PGC proliferation, motility, identity and survival...
  56. ncbi Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    Julie K Stock
    Nuclear Organisation, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 9:1428-35. 2007
    ..These observations provide an insight into the molecular mechanisms that allow ES cells to self-renew and yet retain the ability to generate multiple lineage outcomes...
  57. ncbi Comprehensive comparison of auxin-regulated and brassinosteroid-regulated genes in Arabidopsis
    Hideki Goda
    Plant Science Center, RIKEN, Suehirocho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan
    Plant Physiol 134:1555-73. 2004
    ....
  58. ncbi Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
    C D Helgason
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genes Dev 12:1610-20. 1998
    ..Thus, homozygous disruption of SHIP establishes the crucial role of this molecule in modulating cytokine signaling within the hemopoietic system and provides a powerful model for further delineating its function...
  59. ncbi FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, 10 Center Drive, National Institutes of Health, Bethesda, MD, USA
    Development 125:3615-23. 1998
    ..These data revealed a cooperative function of FGFR-3 and FGFR-4 to promote the formation of alveoli during postnatal lung development...
  60. ncbi Genetic control of Drosophila nerve cord development
    James B Skeath
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Curr Opin Neurobiol 13:8-15. 2003
    ..These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter...
  61. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis...
  62. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins...
  63. ncbi LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs
    Zhonglin Tang
    Department of Gene and Cell Engineering, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China
    Genome Biol 8:R115. 2007
    ..Here, we describe a genome-wide analysis of differences in prenatal skeletal muscle between Tongcheng (a typical indigenous Chinese breed) and Landrace (a leaner Western breed) pigs...
  64. ncbi Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development
    Yoshio Wakamatsu
    Department of Developmental Neurobiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    Dev Dyn 229:74-86. 2004
    ..Developmental Dynamics 229:74-86, 2004...
  65. ncbi Epigenetic instability in ES cells and cloned mice
    D Humpherys
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge MA 02142, USA
    Science 293:95-7. 2001
    ..These data imply that even apparently normal cloned animals may have subtle abnormalities in gene expression...
  66. ncbi Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  67. ncbi Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies
    Frederic P Lemaigre
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 137:62-79. 2009
    ....
  68. ncbi Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    Merce Martin
    INSERM, U682, Strasbourg, France
    Dev Biol 284:399-411. 2005
    ..We conclude that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function...
  69. ncbi Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
    Juhee Jeong
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
    Development 135:2905-16. 2008
    ..We propose a new model for Dlx-mediated mammalian jaw patterning...
  70. ncbi Otx2 regulates subtype specification and neurogenesis in the midbrain
    Bertrand Vernay
    Institut de Génétique et de Biologie Moléculaire et Cellulaire Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale, Universite Louis Pasteur, 67404 Illkirch Cedex, Strasbourg, France
    J Neurosci 25:4856-67. 2005
    ..Altogether, these results demonstrate that Otx2 is required from E10.5 onward to regulate neuronal subtype identity and neurogenesis in the midbrain...
  71. ncbi Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation
    C Begue-Kirn
    Institut de Biologie Medicale, Universite Louis Pasteur, Faculte de Medecine, Strasbourg, France
    Int J Dev Biol 38:405-20. 1994
    ....
  72. ncbi Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
    P Q Thomas
    MRC National Institute for Medical Research, London, UK
    Development 125:85-94. 1998
    ....
  73. ncbi caudal is required for gnathal and thoracic patterning and for posterior elongation in the intermediate-germband cricket Gryllus bimaculatus
    Yohei Shinmyo
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minami-Josanjima-cho, Tokushima City 770-8506, Japan
    Mech Dev 122:231-9. 2005
    ..Since Wnt/Cdx pathways are involved in the posterior patterning of vertebrates, such mechanisms may be conserved in animals that undergo sequential segmentation from the posterior growth zone...
  74. ncbi Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo
    Edward Eivers
    Department of Biochemistry, National University of Ireland, Galway, Ireland
    Int J Dev Biol 48:1131-40. 2004
    ..Our data is consistent with a common pathway for integration of IGF, FGF8 and anti-BMPs in early vertebrate development...
  75. ncbi Anatomical and molecular reinvestigation of lamprey endostyle development provides new insight into thyroid gland evolution
    Bernhard Kluge
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Cologne, Germany
    Dev Genes Evol 215:32-40. 2005
    ....
  76. ncbi Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas
    Ilkka Ketola
    Children's Hospital and Program for Developmental and Reproductive Biology, Biomedicum Helsinki, PO Box 63, Room B525b, 00014 University of Helsinki, Helsinki, Finland
    Mol Cell Endocrinol 226:51-7. 2004
    ..We conclude that GATA-4 is a marker of exocrine pancreatic differentiation, whereas GATA-6 is a marker of endocrine pancreatic development...
  77. ncbi A novel cdc2-related protein kinase expressed in the nervous system
    M A Lazzaro
    Centre for Research in Neuroscience, McGill University and Montreal General Hospital Research Institute, Quebec, Canada
    J Neurochem 69:348-64. 1997
    ....
  78. ncbi A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP
    Park F Cho
    Department of Biochemistry, McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Cell 121:411-23. 2005
    ..This example of cap-dependent translational control that is not mediated by canonical eIF4E defines a new paradigm for translational inhibition involving tethering of the mRNA 5' and 3' ends...
  79. ncbi Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis
    S Filosa
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Illkirch, CU de Strasbourg
    Development 124:2843-54. 1997
    ..Our results also suggest that interaction between gsc and HNF-3beta regulates other signalling molecules required for proper development of the foregut, branchial arches and heart...
  80. ncbi Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
    H Akiyama
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Biochem Biophys Res Commun 235:142-7. 1997
    ..Our data suggest that hh signalling molecules may be involved in chondrogenesis and cartilage differentiation in ATDC5 cells...
  81. ncbi Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe
    C Tribioli
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Gene 203:225-33. 1997
    ..1, where several human genetic diseases involving dysmorphology of the skeleton have been assigned, raises the potential of it being a candidate gene for one of these disorders. O..
  82. ncbi Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis
    D A Kenny
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0650, USA
    Proc Natl Acad Sci U S A 95:11257-62. 1998
    ..Mesenchymal and thymic blast cell expression patterns of LMO4 and LMO2 are consistent with the suggestion that LMO genes inhibit differentiation...
  83. ncbi TAF(II)s mediate activation of transcription in the Drosophila embryo
    F Sauer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Cell 87:1271-84. 1996
    ..This genetic system also presents the opportunity to study the function of basal transcription components in regulating development of complex organisms...
  84. ncbi Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax
    Barbara Noro
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1636-50. 2006
    ..We further demonstrate that the mouse ortholog of hth, Meis1, also encodes a HDless isoform, suggesting that homeodomain-less variants of this gene family are evolutionarily ancient...
  85. ncbi Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1
    Ryan Range
    UMR 7009 CNRS, Université Pierre et Marie Curie Paris 6 Observatoire Océanologique, 06230 Villefranche sur Mer, France
    Development 134:3649-64. 2007
    ..The data are consistent with a model of nodal regulation in which a maternal TGF-beta acts in synergy with maternal transcription factors and with spatial repressors to establish the dorsal-ventral axis of the sea urchin embryo...
  86. ncbi Prostate-specific and androgen-dependent expression of a novel homeobox gene
    C J Bieberich
    Department of Virology, Jerome H Holland Laboratory, Rockville, Maryland 20855, USA
    J Biol Chem 271:31779-82. 1996
    ..1 protein, which likely functions as a transcription factor, plays a prominent role both in the initiation of prostate development and in the maintenance of the differentiated state of prostatic epithelial cells...
  87. ncbi Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain
    M Hallonet
    Max Planck Institut for Biophysical Chemistry, Department of Molecular and Cell Biology, Am Fassberg 11, Germany
    Development 125:2599-610. 1998
    ..The Vax1 gene is thus an interesting new tool to study the rostral ventral forebrain patterning, morphogenesis and evolution as well as the terminal differentiation of the forebrain in mouse and Xenopus...
  88. ncbi Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity
    J B Weiss
    Departments of Developmental Biology and Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5329 USA
    Genes Dev 12:3591-602. 1998
    ....
  89. ncbi Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage
    V W Keng
    Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya, 464 8601, Japan
    Biochem Biophys Res Commun 276:1155-61. 2000
    ..These results indicate that Hex plays an essential role in progenitor cells which commit to the hepatic endoderm and in the hematopoietic differentiation of the monocyte lineage...
  90. ncbi Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Univ Méditerranée AP de Marseille, Luminy Case 907, France
    Development 127:1349-58. 2000
    ..Thus, the loss of function of Phox2b in hindbrain motor neurons exemplifies a novel control point in the generation of CNS neurons...
  91. ncbi NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis
    Christine Biben
    Victor Chang Cardiac Research Institute, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Int J Dev Biol 46:415-22. 2002
    ..These data suggest roles for Nkx2-3 during pharyngeal organogenesis, although the considerable potential for genetic redundancy within and outside of this gene family may mask earlier functions in organ specification...
  92. ncbi Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog
    M Mukhopadhyay
    National Institute of Health, Laboratory of Mammalian Genes and Development, Bethesda, MD, USA
    Gene 293:59-65. 2002
    ..Our observations demonstrate that there is a remarkable degree of sequence conservation at the dip2 locus that is reflected in the nervous system-specific expression of both the Drosophila and mouse homologs...
  93. ncbi The homeodomain-containing gene Xdbx inhibits neuronal differentiation in the developing embryo
    A A Gershon
    Department of Developmental Neurobiology, The Rockefeller University, New York, NY 10021, USA
    Development 127:2945-54. 2000
    ..One role of Xdbx during normal development may therefore be to restrict spatially neuronal differentiation within the neural plate, possibly by altering the neuronal differentiation function of Xash3...
  94. ncbi Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    B G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 31:773-89. 2001
    ..Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord...
  95. ncbi The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
    E Reissmann
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S 17177 Stockholm, Sweden
    Genes Dev 15:2010-22. 2001
    ..Therefore, our results indicate that both ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling...
  96. ncbi A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction
    K Miyama
    New Product Research Laboratories III, Daiichi Pharmaceutical Co, Ltd, Tokyo R and D Center, Kita Kasai, Edogawa ku, Tokyo, 134, Japan
    Dev Biol 208:123-33. 1999
    ..These findings suggest that mDlx5 is a target gene of the BMP signaling pathway and acts as an important regulator of both osteogenesis and dorsoventral patterning of embryonic axis...
  97. ncbi Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node
    X M Zhang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 105:781-92. 2001
    ..Further, we demonstrate an absolute requirement for Hedgehog signaling in sclerotomal development and a role in cardiac morphogenesis.[Dedicated to Rosa Beddington, a pioneer in mammalian embryology]...
  98. ncbi Expression of Dlx genes during the development of the murine dentition
    Z Zhao
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Dev Genes Evol 210:270-5. 2000
    ..The relationship of Dlx gene expression to their genomic organization suggests coordinate regulation of linked genes at early stages but regulatory differences at later stages...
  99. ncbi xPitx1 plays a role in specifying cement gland and head during early Xenopus development
    W Chang
    Department of Biological Sciences, University of Windsor, Ontario, Canada
    Genesis 29:78-90. 2001
    ..Ectopic expression of xPitx1 in ectodermal explants directly promotes cement gland development as there was no evidence that mesodermal or neural tissue was present in explants...
  100. ncbi Hedgehog signaling is required for pituitary gland development
    M Treier
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, CMMW, Room 345, La Jolla, CA 92093 0648, USA
    Development 128:377-86. 2001
    ..Thus, SHH appears to exert effects on both proliferation and cell-type determination in pituitary gland development...
  101. ncbi Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system
    Y Song
    Department of Molecular and Cellular Biology Harvard University, Cambridge, MA 02138, USA
    Mol Cell 6:1143-54. 2000
    ..Combgap is thus a tissue-specific relay between Wingless and its target genes for the determination of cell fate in the visual cortex...

Research Grants193 found, 100 shown here

  1. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric H Davidson; Fiscal Year: 2010
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  2. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2004
    ..abstract_text> ..
  3. DRUGS AND DEVELOPMENT OF ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 1980
    ....
  4. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2009
    ..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
  5. Computational Model of Gene Regulatory Program
    Eric Davidson; Fiscal Year: 2007
    ..abstract_text> ..
  6. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  7. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  8. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2005
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  9. Vernalization a cold-induced regulatory network establishing cellular memory
    Richard Amasino; Fiscal Year: 2007
    ..A general understanding of epigenetic regulation in a range of multi-cellular organisms should ultimately contribute to the development of strategies to treat disease states. ..
  10. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  11. GABAergic Dysfunction in Autism
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  12. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2009
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  13. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  14. Function of active chromatin domains in erythropoiesis
    MICHAEL D BULGER; Fiscal Year: 2010
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  15. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  16. GABAergic Dysfunction in Autism
    SEYYED FATEMI; Fiscal Year: 2009
    ..Such outcomes will be significant, because they are expected to identify biochemical mechanisms responsible for abnormal brain development in early childhood, as seen in autism. ..
  17. Function of active chromatin domains in erythropoiesis
    Michael Bulger; Fiscal Year: 2009
    ..As such, it has relevance to disorders in which tissue-specific gene expression is disrupted - which include a number of cancers - as well as gene therapy approaches involving stable transgene expression in specific cell types. ..
  18. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  19. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2003
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  20. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2009
    ..Verifying the function of those newly discovered genes in mouse development will greatly enhance our ability to move the already funded R01 project toward translational research. ..
  21. ISOLATION & FUNCTION OF THE XLIS NEURONAL MIGRATION GENE
    Margaret Ross; Fiscal Year: 2003
    ....
  22. Hematopoietic Regulation of GATA Switches
    Emery H Bresnick; Fiscal Year: 2010
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  23. Chromatin remodeling complexes in heart development
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  24. Developmental Regulation of MacroH2A1 Chromatin Assembly
    Theodore Rasmussen; Fiscal Year: 2009
    ..Research proposed here will provide basic insights into differentiation biology and provide a framework for future attempts to achieve rationally-guided ES cell differentiation. ..
  25. MECHANISM OF THE HUMAN BETA-GLOBIN LOCUS CONTROL REGION
    EMERY BRESNICK; Fiscal Year: 2005
    ..The long-term objective is to therapeutically modulate beta-globin gene expression in humans with hemoglobinopathies by perturbing specific steps of the mechanism by which the LCR regulate the beta-globin genes. ..
  26. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2007
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  27. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..The results obtained will be relevant to human diseases that affect these processes, including arrhythmias after infarct and cardiac remodeling in heart failure. ..
  28. COACTIVATORS THAT MEDIATE BETA GLOBIN LCR FUNCTION
    EMERY BRESNICK; Fiscal Year: 2002
    ..abstract_text> ..
  29. ISOLATION AND FUNCTION OF THE XLIS NEURONAL MIGRATION
    Margaret Ross; Fiscal Year: 1999
    ....
  30. Chromatin remodeling complexes in heart development
    BENOIT BRUNEAU; Fiscal Year: 2009
    ..We will discover new and important gene regulation pathways that form the heart, and importantly we will understand how these pathways are dysfunctional in human disease. ..
  31. Pro-inflammatory gene regulation in a native chromatin environment
    Stephen T Smale; Fiscal Year: 2010
    ..The long-term goal of this research is to develop strategies for the selective modulation of pro-inflammatory genes in the context of human disease. ..
  32. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 2009
    ..abstract_text> ..
  33. Hematopoietic Regulation of GATA Switches
    EMERY BRESNICK; Fiscal Year: 2007
    ..The studies will reveal how GATA switches regulate GATA-2 transcription, how GATA-1 and GATA-2 select DMA motifs, and insights of broad relevance to diverse developmental processes. ..
  34. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2009
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  35. REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    STEPHEN SMALE; Fiscal Year: 1999
    ..Eventually, the investigators hope to use the knowledge generated during these studies to elucidate the molecular events that regulate early lymphoid development and the fetal/adult lymphopoietic transition. ..