gene expression regulation

Summary

Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action at the level of transcription or translation. These processes include gene activation and genetic induction.

Top Publications

  1. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
  2. pmc A new mathematical model for relative quantification in real-time RT-PCR
    M W Pfaffl
    Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
    Nucleic Acids Res 29:e45. 2001
  3. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
  4. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
  5. pmc Statistical significance for genomewide studies
    John D Storey
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:9440-5. 2003
  6. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
  7. ncbi Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Cancer Res 64:5245-50. 2004
  8. ncbi Global quantification of mammalian gene expression control
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13092 Berlin, Germany
    Nature 473:337-42. 2011
  9. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
  10. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003

Detail Information

Publications258 found, 100 shown here

  1. pmc MicroRNAs: target recognition and regulatory functions
    David P Bartel
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 136:215-33. 2009
    ..This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes...
  2. pmc A new mathematical model for relative quantification in real-time RT-PCR
    M W Pfaffl
    Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
    Nucleic Acids Res 29:e45. 2001
    ..High accuracy and reproducibility (<2.5% variation) were reached in LightCycler PCR using the established mathematical model...
  3. ncbi Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    Benjamin P Lewis
    Cell 120:15-20. 2005
    ..Targeting was also detected in open reading frames. In sum, well over one third of human genes appear to be conserved miRNA targets...
  4. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    ....
  5. pmc Statistical significance for genomewide studies
    John D Storey
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:9440-5. 2003
    ..Our approach avoids a flood of false positive results, while offering a more liberal criterion than what has been used in genome scans for linkage...
  6. ncbi The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    R C Lee
    Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
    Cell 75:843-54. 1993
    ..elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction...
  7. ncbi Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Cancer Res 64:5245-50. 2004
    ..The presented strategy can be applied to evaluate the suitability of any normalization gene candidate in any kind of experimental design and should allow more reliable normalization of RT-PCR data...
  8. ncbi Global quantification of mammalian gene expression control
    Björn Schwanhäusser
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13092 Berlin, Germany
    Nature 473:337-42. 2011
    ..Quantitative information about all stages of gene expression provides a rich resource and helps to provide a greater understanding of the underlying design principles...
  9. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Surprisingly, four nucleotide excision repair genes were induced, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation...
  10. ncbi Prediction of mammalian microRNA targets
    Benjamin P Lewis
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 115:787-98. 2003
    ..The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions...
  11. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway...
  12. pmc A mammalian microRNA expression atlas based on small RNA library sequencing
    Pablo Landgraf
    Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Box 186, The Rockefeller University, New York, NY 10021, USA
    Cell 129:1401-14. 2007
    ..We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses...
  13. ncbi MicroRNAs: small RNAs with a big role in gene regulation
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Genet 5:522-31. 2004
  14. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  15. pmc The impact of microRNAs on protein output
    Daehyun Baek
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 455:64-71. 2008
    ..The impact of microRNAs on the proteome indicated that for most interactions microRNAs act as rheostats to make fine-scale adjustments to protein output...
  16. ncbi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
    ..Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53...
  17. pmc Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    Haiyan Xu
    Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    J Clin Invest 112:1821-30. 2003
    ..We propose that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue...
  18. pmc Human MicroRNA targets
    Bino John
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 2:e363. 2004
    ..microrna.org. Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes...
  19. ncbi Long non-coding RNAs: insights into functions
    Tim R Mercer
    Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Rev Genet 10:155-9. 2009
    ..We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA...
  20. ncbi The widespread regulation of microRNA biogenesis, function and decay
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 11:597-610. 2010
    ..Such regulation has an important role in the context-specific functions of miRNAs...
  21. ncbi Signal integration in the endoplasmic reticulum unfolded protein response
    David Ron
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Rev Mol Cell Biol 8:519-29. 2007
    ..The arms of the UPR are integrated to provide a response that remodels the secretory apparatus and aligns cellular physiology to the demands imposed by ER stress...
  22. pmc Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    Ahmad M Khalil
    The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 106:11667-72. 2009
    ..We propose a model in which some lincRNAs guide chromatin-modifying complexes to specific genomic loci to regulate gene expression...
  23. ncbi BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks
    Steven Maere
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent University, Technologiepark 927, B 9052, Ghent, Belgium
    Bioinformatics 21:3448-9. 2005
    ....
  24. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
    ..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
  25. pmc TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes
    V Matys
    BIOBASE GmbH, Halchtersche Strasse 33, D 38304 Wolfenbuttel, Germany
    Nucleic Acids Res 34:D108-10. 2006
    ..The here described public releases, TRANSFAC 7.0 and TRANSCompel 7.0, are accessible under http://www.gene-regulation.com/pub/databases.html...
  26. pmc Histone modifications at human enhancers reflect global cell-type-specific gene expression
    Nathaniel D Heintzman
    Ludwig Institute for Cancer Research, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, California 92093 0653, USA
    Nature 459:108-12. 2009
    ..Our results define over 55,000 potential transcriptional enhancers in the human genome, significantly expanding the current catalogue of human enhancers and highlighting the role of these elements in cell-type-specific gene expression...
  27. pmc Regulation of translation initiation in eukaryotes: mechanisms and biological targets
    Nahum Sonenberg
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cell 136:731-45. 2009
    ....
  28. ncbi Biogenesis of small RNAs in animals
    V Narry Kim
    School of Biological Sciences and Center for National Creative Research, Seoul National University, Seoul, 151 742, Korea
    Nat Rev Mol Cell Biol 10:126-39. 2009
    ..This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells...
  29. pmc MicroRNA genes are transcribed by RNA polymerase II
    Yoontae Lee
    Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
    EMBO J 23:4051-60. 2004
    ..These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes...
  30. ncbi High-resolution profiling of histone methylations in the human genome
    Artem Barski
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cell 129:823-37. 2007
    ..Our data provide new insights into the function of histone methylation and chromatin organization in genome function...
  31. pmc Understanding mechanisms underlying human gene expression variation with RNA sequencing
    Joseph K Pickrell
    Department of Human Genetics, The University of Chicago, Chicago 60637, USA
    Nature 464:768-72. 2010
    ..Our results illustrate the power of high-throughput sequencing for the joint analysis of variation in transcription, splicing and allele-specific expression across individuals...
  32. pmc A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
    Leonardo Salmena
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 146:353-8. 2011
    ....
  33. ncbi Coordination of circadian timing in mammals
    Steven M Reppert
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 418:935-41. 2002
    ..However, these independent rhythms are tamed by a master clock in the brain, which coordinates tissue-specific rhythms according to light input it receives from the outside world...
  34. pmc Widespread transcription at neuronal activity-regulated enhancers
    Tae Kyung Kim
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 465:182-7. 2010
    ..These findings reveal that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis...
  35. pmc A diverse range of gene products are effectors of the type I interferon antiviral response
    John W Schoggins
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 472:481-5. 2011
    ..Several ISGs, including ADAR, FAM46C, LY6E and MCOLN2, enhanced the replication of certain viruses, highlighting another layer of complexity in the highly pleiotropic type I interferon system...
  36. pmc Identification of functional elements and regulatory circuits by Drosophila modENCODE
    Sushmita Roy
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 330:1787-97. 2010
    ..Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation...
  37. ncbi Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    Rik Derynck
    Department of Growth and Development, University of California at San Francisco, San Francisco, California 94143 0640, USA
    Nature 425:577-84. 2003
    ..Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses...
  38. ncbi Regulation of mRNA translation and stability by microRNAs
    Marc Robert Fabian
    Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Annu Rev Biochem 79:351-79. 2010
    ..We also address the issue of cellular localization of miRNA-mediated events and a role for RNA-binding proteins in activation or relief of miRNA repression...
  39. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
  40. ncbi Many roads to maturity: microRNA biogenesis pathways and their regulation
    Julia Winter
    Helmholtz University Group Molecular RNA Biology and Cancer, German Cancer Research Center DKFZ and Institute of Pathology, University of Heidelberg, B150 INF 581, D 69120 Heidelberg, Germany
    Nat Cell Biol 11:228-34. 2009
    ..Here we review the recent advances in knowledge of the microRNA biosynthesis pathways and discuss their impact on post-transcriptional microRNA regulation during tumour development...
  41. ncbi A microRNA component of the p53 tumour suppressor network
    Lin He
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 447:1130-4. 2007
    ..The p53 network suppresses tumour formation through the coordinated activation of multiple transcriptional targets, and miR-34 may act in concert with other effectors to inhibit inappropriate cell proliferation...
  42. pmc miRBase: microRNA sequences, targets and gene nomenclature
    Sam Griffiths-Jones
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 34:D140-4. 2006
    ..miRBase Sequences is the primary online repository for miRNA sequence data and annotation. miRBase Targets is a comprehensive new database of predicted miRNA target genes. miRBase is available at http://microrna.sanger.ac.uk/...
  43. ncbi The mechanism of eukaryotic translation initiation and principles of its regulation
    Richard J Jackson
    Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK
    Nat Rev Mol Cell Biol 11:113-27. 2010
    ....
  44. pmc miRTarBase: a database curates experimentally validated microRNA-target interactions
    Sheng Da Hsu
    Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin Chu 300, Taiwan
    Nucleic Acids Res 39:D163-9. 2011
    ..miRTarBase is now available on http://miRTarBase.mbc.nctu.edu.tw/, and is updated frequently by continuously surveying research articles...
  45. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
    ..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
  46. ncbi microRNA functions
    Natascha Bushati
    Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany 69117
    Annu Rev Cell Dev Biol 23:175-205. 2007
    ..In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization. Here, we review recent work in animal models that provide insight into the diverse roles of miRNAs in vivo...
  47. ncbi Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    Catherine L Jopling
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Science 309:1577-81. 2005
    ..Therefore, miR-122 is likely to facilitate replication of the viral RNA, suggesting that miR-122 may present a target for antiviral intervention...
  48. ncbi Improved scoring of functional groups from gene expression data by decorrelating GO graph structure
    Adrian Alexa
    Max Planck Institute for Informatics Stuhlsatzenhausweg 85, D 66123 Saarbrucken, Germany
    Bioinformatics 22:1600-7. 2006
    ..g. based on Gene Ontology (GO). We develop methods that increase the explanatory power of this approach by integrating knowledge about relationships between the GO terms into the calculation of the statistical significance...
  49. pmc Small silencing RNAs: an expanding universe
    Megha Ghildiyal
    Department of Biochemistry and Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Genet 10:94-108. 2009
    ....
  50. ncbi Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments
    Rainer Breitling
    Plant Science Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    FEBS Lett 573:83-92. 2004
    ..In addition, using RP can lead to a sharp reduction in the number of replicate experiments needed to obtain reproducible results...
  51. ncbi Switching from repression to activation: microRNAs can up-regulate translation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 318:1931-4. 2007
    ..Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle...
  52. pmc CTCF: master weaver of the genome
    Jennifer E Phillips
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Cell 137:1194-211. 2009
    ....
  53. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  54. pmc miRecords: an integrated resource for microRNA-target interactions
    Feifei Xiao
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Nucleic Acids Res 37:D105-10. 2009
    ..The miRecords is available at http://miRecords.umn.edu/miRecords...
  55. ncbi TIGR Gene Indices clustering tools (TGICL): a software system for fast clustering of large EST datasets
    Geo Pertea
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Bioinformatics 19:651-2. 2003
    ..The system can run on multi-CPU architectures including SMP and PVM...
  56. pmc Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    Peter V Kharchenko
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:480-5. 2011
    ..This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function...
  57. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Nat Neurosci 7:847-54. 2004
    ..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
  58. pmc An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    Matthew P R Berry
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 466:973-7. 2010
    ..Our study also provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic...
  59. ncbi Translating the histone code
    T Jenuwein
    Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Science 293:1074-80. 2001
    ....
  60. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  61. pmc Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    Ryan D Morin
    Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Genome Res 18:610-21. 2008
    ..Included among the high-ranked predicted gene targets are those implicated in differentiation, cell cycle control, programmed cell death, and transcriptional regulation...
  62. pmc Conserved role of intragenic DNA methylation in regulating alternative promoters
    Alika K Maunakea
    Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158, USA
    Nature 466:253-7. 2010
    ..These results support a major role for intragenic methylation in regulating cell context-specific alternative promoters in gene bodies...
  63. pmc miR2Disease: a manually curated database for microRNA deregulation in human disease
    Qinghua Jiang
    Center for Biomedical Informatics, School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China
    Nucleic Acids Res 37:D98-104. 2009
    ..Once approved by the submission review committee, the submitted records will be included in the database. miR2Disease is freely available at http://www.miR2Disease.org...
  64. pmc Long noncoding RNAs: functional surprises from the RNA world
    Jeremy E Wilusz
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 23:1494-504. 2009
    ..It is thus becoming increasingly clear that long noncoding RNAs can function via numerous paradigms and are key regulatory molecules in the cell...
  65. ncbi Nanog safeguards pluripotency and mediates germline development
    Ian Chambers
    MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
    Nature 450:1230-4. 2007
    ..We surmise that Nanog stabilizes embryonic stem cells in culture by resisting or reversing alternative gene expression states...
  66. pmc Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    Sung Wook Chi
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 460:479-86. 2009
    ..Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions...
  67. pmc Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    Robert E Lanford
    Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Science 327:198-201. 2010
    ..The prolonged virological response to SPC3649 treatment without HCV rebound holds promise of a new antiviral therapy with a high barrier to resistance...
  68. ncbi The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    Mitsutoshi Yoneyama
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Nat Immunol 5:730-7. 2004
    ..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
  69. ncbi Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    F Bunz
    The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 282:1497-501. 1998
    ..Thus, p53 and p21 appear to be essential for maintaining the G2 checkpoint in human cells...
  70. ncbi IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    Jochen Schmitz
    Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 23:479-90. 2005
    ..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
  71. ncbi WAF1, a potential mediator of p53 tumor suppression
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cell 75:817-25. 1993
    ..These studies define a gene whose expression is directly induced by p53 and that could be an important mediator of p53-dependent tumor growth suppression...
  72. ncbi The complex language of chromatin regulation during transcription
    Shelley L Berger
    The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
    Nature 447:407-12. 2007
    ..Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes...
  73. pmc ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
    Adam A Margolin
    Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
    BMC Bioinformatics 7:S7. 2006
    ..This method uses an information theoretic approach to eliminate the majority of indirect interactions inferred by co-expression methods...
  74. pmc PID: the Pathway Interaction Database
    Carl F Schaefer
    National Cancer Institute, Center for Biomedical Informatics and Information Technology, Rockville MD, USA
    Nucleic Acids Res 37:D674-9. 2009
    ..The database is updated with new pathway content every month and supplemented by specially commissioned articles on the practical uses of other relevant online tools...
  75. pmc Common regulatory variation impacts gene expression in a cell type-dependent manner
    Antigone S Dimas
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1HH, Cambridge, UK
    Science 325:1246-50. 2009
    ..These data suggest that the complete regulatory variant repertoire can only be uncovered in the context of cell-type specificity...
  76. pmc Variation in transcription factor binding among humans
    Maya Kasowski
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 328:232-5. 2010
    ..Our results indicate that many differences in individuals and species occur at the level of TF binding, and they provide insight into the genetic events responsible for these differences...
  77. ncbi Evolution and functions of long noncoding RNAs
    Chris P Ponting
    MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK
    Cell 136:629-41. 2009
    ..Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease...
  78. pmc High-resolution mapping of expression-QTLs yields insight into human gene regulation
    Jean Baptiste Veyrieras
    Department of Human Genetics, The University of Chicago, Chicago, IL, USA
    PLoS Genet 4:e1000214. 2008
    ..Our results suggest an important role for mRNA stability in determining steady-state mRNA levels, and highlight the potential of eQTL mapping as a high-resolution tool for studying the determinants of gene regulation...
  79. ncbi Genetics of gene expression and its effect on disease
    Valur Emilsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:423-8. 2008
    ..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
  80. ncbi Genome-wide evolutionary analysis of eukaryotic DNA methylation
    Assaf Zemach
    Department of Plant and Microbial Biology, 211 Koshland Hall, University of California, Berkeley, CA 94720, USA
    Science 328:916-9. 2010
    ..Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes...
  81. pmc Diversity and complexity in DNA recognition by transcription factors
    Gwenael Badis
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Science 324:1720-3. 2009
    ..This complexity in DNA recognition may be important in gene regulation and in the evolution of transcriptional regulatory networks...
  82. pmc The database of experimentally supported targets: a functional update of TarBase
    Giorgos L Papadopoulos
    Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, 166 72 Varkiza, Synaptic Ltd, 711 10 Heraklion, Greece
    Nucleic Acids Res 37:D155-8. 2009
    ..Additionally, the database is functionally linked to several other relevant and useful databases such as Ensembl, Hugo, UCSC and SwissProt. The TarBase5.0 database can be queried or downloaded from http://microrna.gr/tarbase...
  83. pmc An atlas of combinatorial transcriptional regulation in mouse and man
    Timothy Ravasi
    The FANTOM Consortium, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 140:744-52. 2010
    ..The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution...
  84. ncbi Pre-mRNA processing reaches back to transcription and ahead to translation
    Melissa J Moore
    Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 136:688-700. 2009
    ..The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven...
  85. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  86. pmc In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1253-70. 2003
    ..The isolation and characterization of these stem cells should help elucidate the molecular pathways that govern normal mammary development and carcinogenesis...
  87. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  88. pmc Histone deacetylases (HDACs): characterization of the classical HDAC family
    Annemieke J M de Ruijter
    Academic Medical Centre, University of Amsterdam, Amsterdam, The, Netherlands
    Biochem J 370:737-49. 2003
    ..This challenging field has generated many fascinating results which will ultimately lead to a better understanding of the mechanism of gene transcription as a whole...
  89. pmc Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA
    Science 330:1775-87. 2010
    ..Integrating data types, we built statistical models relating chromatin, transcription factor binding, and gene expression. Overall, our analyses ascribed putative functions to most of the conserved genome...
  90. ncbi Stats: transcriptional control and biological impact
    David E Levy
    Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Nat Rev Mol Cell Biol 3:651-62. 2002
    ..In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research...
  91. pmc The human disease network
    Kwang Il Goh
    Center for Complex Network Research and Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA
    Proc Natl Acad Sci U S A 104:8685-90. 2007
    ..A selection-based model explains the observed difference between essential and disease genes and also suggests that diseases caused by somatic mutations should not be peripheral, a prediction we confirm for cancer genes...
  92. ncbi Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    H P Harding
    Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA
    Nature 397:271-4. 1999
    ..These properties implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress...
  93. ncbi Smad transcription factors
    Joan Massague
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:2783-810. 2005
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior...
  94. ncbi The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    P H Maxwell
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nature 399:271-5. 1999
    ..Thus, constitutive HIF-1 activation may underlie the angiogenic phenotype of VHL-associated tumours. The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing...
  95. pmc Differential chromatin marking of introns and expressed exons by H3K36me3
    Paulina Kolasinska-Zwierz
    The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Genet 41:376-81. 2009
    ..We propose that H3K36me3 exon marking in chromatin provides a dynamic link between transcription and splicing...
  96. ncbi Interferon-gamma: an overview of signals, mechanisms and functions
    Kate Schroder
    Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Leukoc Biol 75:163-89. 2004
    ..In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-alpha, interleukin-4, type I IFNs, and lipopolysaccharide are discussed...
  97. pmc RNA processing and its regulation: global insights into biological networks
    Donny D Licatalosi
    Howard Hughes Medical Institute, Laboratory of Molecular Neuro Oncology, The Rockefeller University, New York, New York 10021, USA
    Nat Rev Genet 11:75-87. 2010
    ..Together these are providing new insights into molecular cell biology and disease...
  98. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..These findings demonstrate that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense...
  99. pmc Insights from genomic profiling of transcription factors
    Peggy J Farnham
    Department of Pharmacology and the Genome Center, University of California Davis, Davis, California 95616, USA
    Nat Rev Genet 10:605-16. 2009
    ..It also suggests future experiments that may further our understanding of the causes and consequences of transcription factor-genome interactions...
  100. ncbi MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
    Changchun Xiao
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:146-59. 2007
    ....
  101. ncbi Nucleosome positioning and gene regulation: advances through genomics
    Cizhong Jiang
    Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 10:161-72. 2009
    ..A detailed picture is starting to emerge of how diverse factors, including underlying DNA sequences and chromatin remodelling complexes, influence nucleosome positioning...

Research Grants62

  1. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..normal HSC function and leads to the formation of leukemia initiating cells (LIC), superordinate gene expression regulation by epigenetic mechanisms, is still poorly understood...
  2. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
    ..These studies will provide novel information regarding the role of the UPR on gene expression regulation and how mRNA structure may contribute to the pathogenesis of genetic disorders...
  3. Histone modifications and respiratory effects of traffic particle exposure
    Lifang Hou; Fiscal Year: 2013
    ..This observation provides a tremendous opportunity to develop new biomarkers that are related to gene expression regulation. Histones are nuclear globular proteins that can be covalently modified by the addition of methyl, ..
  4. Function and regulation of Lhx genes in craniofacial development
    Juhee Jeong; Fiscal Year: 2010
    ..In addition, the results will significantly enhance our overall knowledge on gene expression regulation during craniofacial and dental development, and thus facilitate identification and understanding of ..
  5. The Role of The Histone Epigenome in the Pathophysiology of Endometriosis
    MARICARMEN COLON; Fiscal Year: 2012
    ..including deacetylation by histone deacetylases or HDACs, has recently emerged as a key mechanism of gene expression regulation in cancer and other diseases6-8...
  6. Identification, Discovery, and Public Archiving of RNA Structural Motifs
    Shaojie Zhang; Fiscal Year: 2013
    ..applicant): The non-coding RNAs play many functional roles in biological processes, such as catalysis, gene expression regulation and RNA splicing...
  7. MONOKINE GENE EXPRESSION/REGULATION IN LUNG INJURY
    STEVEN LYNN KUNKEL; Fiscal Year: 2013
    ..We have experimentally modeled the long-term effects of severe sepsis and have uncovered important mechanisms that lead to impaired immune cell function associated with the chronic aspect of this disease. ..
  8. Role of Epigenetics in the Regulation of Blood Pressure
    Methode Bacanamwo; Fiscal Year: 2012
    ..D. in 1996 from the University of Illinois, Dr. Bacanamwo conducted research in gene expression regulation using bacteria, yeast, and plant models as a postdoctoral fellow...
  9. BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMA
    Sergio A Jimenez; Fiscal Year: 2010
    ..Specific Aim 2: Examination of alterations in non-Smad pathways of collagen gene expression regulation focusing on the identification of abnormalities in RhoA, geranylgeranyl, and PKC8-mediated steps of ..
  10. Interdisciplinary Training in Virology and Gene Therapy
    Ren Sun; Fiscal Year: 2013
    ..The research interests of our faculty encompass viral entry, viral gene expression regulation, replication of viral genome, cell biology during viral infection, viral particle assembly, viral ..
  11. Functional characterization of piRNPs
    Zissimos Mourelatos; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our understanding of gene expression regulation has changed radically with the discovery of ribonucleoprotein (RNP) complexes programmed with small RNAs...
  12. Elucidating the Role of Akt and Keratins in Autophagy and Tumorigenesis
    Richard C Wang; Fiscal Year: 2013
    ..These studies will transform our current understanding of how autophagy is regulated and impact how autophagy is manipulated to treat cancer in future clinical trials. ..
  13. Genome-wide identification of miRNAs associated with alcoholism endophenotypes
    KATHERINA KECHRIS-MAYS; Fiscal Year: 2013
    ..project is to examine how variation modulated through micro RNA (miRNA) activity and binding affects gene expression regulation in the brains of mice and is associated with alcoholism related traits (or endophenotypes)...
  14. An in vitro Genome-wide Study of Chromatin Structure and Transcription Regulation
    MATTHEW JOHN ROSSI; Fiscal Year: 2013
    ..With this assay aspects of gene expression regulation will be investigated in regards to transcription factor binding and the transcriptional requirements of ..
  15. Role of JMJD1A in hypoxia-induced EMT and prostate cancer stem cells
    Jianfei Qi; Fiscal Year: 2012
    ..be mentored by leaders in the fields of cancer biology, signal transduction, prostate cancer stem cells, gene expression regulation and epigenetics (as detailed in my Career Development Plan)...
  16. Role of JMJD1A in hypoxia-induced EMT and prostate cancer stem cells
    Jianfei Qi; Fiscal Year: 2013
    ..be mentored by leaders in the fields of cancer biology, signal transduction, prostate cancer stem cells, gene expression regulation and epigenetics (as detailed in my Career Development Plan)...
  17. Genomic regulatory sequence analysis for alcohol-related phenotypes
    KATHERINA KECHRIS-MAYS; Fiscal Year: 2011
    ..variations associated with alcoholism related traits can affect several different mechanisms, including gene expression regulation. The goal of this work is to study mammalian model systems to identify genomic regulatory sequences that ..
  18. The Osteoblast as a Determinant of Leukemogenesis
    Stavroula Kousteni; Fiscal Year: 2013
    ..These studies may identify the osteoblast, as a determinant of AML. ..
  19. Epigenetic and Genetic Dissection of Drug Response
    Wei Zhang; Fiscal Year: 2012
    ..Since DNA methylation at the CpG sites of gene promoter regions is a crucial mechanism of gene expression regulation, expanding the current whole genome genetic (e.g., SNP genotypes) and phenotypic data (e.g...
  20. Novel Mechanisms of EGFR Gene Expression Regulation
    Marianela Perez Torres; Fiscal Year: 2010
    ..A full understanding of the regulators of EGFR expression is needed to design sound therapeutic approaches for patients with EGFR over expressing tumors. ..
  21. Gene expression regulatory circuitry and microRNAs in midbrain dopamine neurons
    Asa Abeliovich; Fiscal Year: 2013
    ..Here we propose to more broadly define the level of complexity of gene expression regulation by miRNA in mDNs, and to determine the function of these forms of regulation in vivo...
  22. Gene Network Perturbations in Alcohol Dependence - A Systems Biology Approach
    Pietro P Sanna; Fiscal Year: 2013
    ..The CNSi will integrate multiple levels of gene expression regulation including the transcriptional (mRNA), post-transcriptional (miRNA) and post-translational (protein-..
  23. Genetic Regulation of Gene Expression and its Impact on Phenotypes
    Chiara Sabatti; Fiscal Year: 2013
    ..in the collection of a data set that promises to offer unprecedented opportunities to understand gene expression regulation in humans, its modulation across tissues, and its genetic determinants...
  24. Caffeine regulates splicing of cancer-related genes: dissecting the mechanism
    Kathleen W Scotto; Fiscal Year: 2011
    ..to human proteomic complexity and functional diversity, playing a key role in developmental decisions, gene expression regulation and, when aberrant, in human disease onset...
  25. Deregulation of host functions and persistence of KSHV
    Ren Sun; Fiscal Year: 2012
    ..To understand the mechanisms of KSHV persistence, concentrated on at the level of gene expression regulation and immune evasion, four laboratories in California join forces...
  26. Regulation of transcriptional initiation by the 19S proteasome subcomplex.
    Sukesh R Bhaumik; Fiscal Year: 2013
    ....
  27. Biomedical Genomics Center: Next-Generation Sequencing Instrumentation
    Kenneth B Beckman; Fiscal Year: 2010
    ..In short, the GAIIx will enable inquiries that are simply not achievable at present, and will therefore help UMN researchers move science closer to cures for important human diseases. ..
  28. Informatic profiling of clinically relevant mutation
    SEAN DAVID MOONEY; Fiscal Year: 2013
    ..to include the challenge of understanding genetic disease mutations and polymorphisms that affect gene expression regulation in noncoding regions...
  29. Yeast as a model for understanding gene expression adaptation
    Hunter B Fraser; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): To what extent changes in gene expression regulation drive the evolutionary innovations of life is an important unresolved question. In particular, the role of cis-regulation has been contentious...
  30. REGULATION OF PROLYL HYDROXYLASE
    Richard Berg; Fiscal Year: 1992
    ....
  31. COMPARISON OF RAT & TROUT HEPATIC P450 INDUCTION
    JOHN LECH; Fiscal Year: 1993
    ..These studies will have broad application in the areas of gene expression regulation in eucaryotes, mechanisms of signal transduction, the regulation of gene expression during development, ..
  32. REGULATION OF GAD PROTEIN LEVELS AND GENE EXPRESSION
    Karin Rimvall; Fiscal Year: 1993
    ..It has been reported that estradiol decrease GAD67 mRNA levels in the brain and it is well-known that estradiol act at the level of nuclear DNA to regulate gene expression...
  33. REGULATION OF GENE EXPRESSION BY INSULIN-MIMETIC AGENTS
    Susan Stapleton; Fiscal Year: 1992
    ....
  34. microRNA biogenesis and function in spinal muscular atrophy
    Zissimos Mourelatos; Fiscal Year: 2007
    ..miRNAs have the capacity to regulate numerous genes and they may exert profound effects in gene expression regulation. We have identified a novel RNP, termed microRNP (miRNP), that contains miRNAs, the Argonaute2 protein ..
  35. Fas Ligand Gene Transfer Apoptosis Synovial Fibroblasts
    Haidi Zhang; Fiscal Year: 2004
    ..This project simplifies the current problems of gene delivery, gene target and gene expression regulation in human gene therapy...
  36. Modulation of nucleosome dynamics
    ANDREW ANDREWS; Fiscal Year: 2009
    ..These data should also aid in our understanding of transcription in the context of chromatin. ..
  37. SRCAP Regulation of CREB and GR-mediated Transcription
    John Chrivia; Fiscal Year: 2005
    ..We propose to determine whether this repression of CREB-mediated transcription occurs through formation of a DBX-SRCAP complex. ..
  38. Regulation of mRNA Decay in Yeast by Puf Proteins
    WENDY OLIVAS; Fiscal Year: 2005
    ..The results of these studies will provide insight into how Puf proteins recognize and regulate mRNA in yeast and other eukaryotes, and into the general principles of 3' UTR control of gene expression. ..
  39. RESEARCH TRAINING IN BLOOD AND VASCULAR BIOLOGY
    Sandor Shapiro; Fiscal Year: 1999
    ..In addition, resources of the Cardeza Foundation library and conference room, medical illustration unit, clinical laboratory, and administrative facilities and personnel will be available for support of this training grant. ..
  40. GENE EXPRESSION REGULATION DURING ODONTAGENESIS
    Mary Macdougall; Fiscal Year: 2004
    ..abstract_text> ..
  41. 3' end formation of human type I and II collagen mRNAs
    CAROL LUTZ; Fiscal Year: 2007
    ..will expand our goal of better understanding the expression of collagens, and how mutations and abnormal gene expression regulation can initiate a disease state...
  42. REGULATION OF CLASS II GENE EXPRESSION
    Laurie Glimcher; Fiscal Year: 1990
    ..The analysis of these and other Ia variant cell lines may prove useful in understanding the molecular mechanisms involved in the control of Class II gene expression...
  43. PHOSPHOLIPASE D
    LARRY DANIEL; Fiscal Year: 1999
    ..The topics to be addressed are: PLD Gene Structure, PLD Gene Expression, Regulation of PLD (two sessions), PLD in Signal Transduction (two sessions), PLD in Subcellular Trafficking and Vesicle Transport, PLD in Yeast and Plants. ..
  44. Transcriptional Regulation in hMLH1-Silenced Colon Cells
    W Sedwick; Fiscal Year: 2007
    ..Mechanistic differentiation of methylation-related gene expression regulation will also be further dissected employing antisense RNAs to specific histone deacetylases...
  45. Mechanisms Regulating Sterol Biosynthesis
    Joseph Nickels; Fiscal Year: 2005
    ..We will determine the minimal ERG26 promoter sequences required for ERG26 gene expression regulation using ERG26 promoter-lacZ fusion technology...
  46. Chemoattractant Regulation of Leukocyte Gene Expression
    Richard Ye; Fiscal Year: 2007
    ..Collectively, these studies are designed to test the central hypothesis that chemoattractant receptors regulate gene expression through differential coupling to G proteins. ..
  47. REGULATION OF MURINE 21-HYDROXYLASE GENE EXPRESSION
    Jonathan Seidman; Fiscal Year: 1992
    ..6) Clone the genes encoding the transacting factors. Characterization of these proteins and the genes that encode them should provide considerable insight into the process of tissue-specific gene expression...
  48. REGULATION OF LIVER GROWTH AND FUNCTION
    Leonard Jefferson; Fiscal Year: 1993
    ..They should also provide new insights into biochemical events involved in peptide-chain initiation and gene expression...
  49. REGULATION OF ADENOSINE DEAMINASE GENE EXPRESSION
    RODNEY KELLEMS; Fiscal Year: 1991
    ..level of ADA transcriptional activity account for tissue and cell specific differences in ADA mRNA abundance? What are the cis- regulatory elements associated with proper cell specific and developmental regulation of ADA gene expression?..
  50. Computational Tools for Bayesian Mixture Modeling
    Mario Medvedovic; Fiscal Year: 2004
    ..Understanding of gene expression regulation mechanisms is likely to improve our ability to effectively treat human disease and predict effects of ..
  51. Regulation of Gene Expression by DNA Methylation
    John McCarrey; Fiscal Year: 2002
    ....
  52. REGULATION OF VASCULAR SMOOTH MUSCLE MRNA STABILITY
    Thomas Murphy; Fiscal Year: 2005
    ....
  53. Molecular basis of transvection
    MARIANO LABRADOR SAN JOSE; Fiscal Year: 2007
    ..in understanding the mechanisms presiding enhancer-promoter interactions and the role of insulators in gene expression regulation. The goal of this proposal is to explore the molecular mechanisms underlying the phenomenon of ..
  54. FASEB SUMMER RESEARCH CONFERENCE: PROTEIN KINASES
    Jackie Corbin; Fiscal Year: 1991
    ..The response to previous conferences has been excellent, and the organizers are committed to make the 1991 conference the best yet. It is deserving of consideration by NIH for partial support...
  55. REPRESSION AND REGULATION OF GENE EXPRESSION
    Danny Reinberg; Fiscal Year: 2000
    ..However, an equally important mechanism for regulating gene expression is repression. Studies carried out during the past years have uncovered a mechanism for repression involving protein:protein interactions. ..
  56. Small RNA profiling during spermatogenesis
    Wei Yan; Fiscal Year: 2006
    ..For decades, reproductive biologists have been trying to dissect the regulatory mechanisms involved in gene expression regulation during spermatogenesis...
  57. The Role and Mechanism of RGS12 in Bone Resorption
    Shuying Yang; Fiscal Year: 2006
    ..knockout model to define the function of RGS12 in regulating Ca2+ signal in osteoclast, in osteoclast gene expression regulation, and in osteoclast differentiation and activation so as to apply this knowledge to develop new ..
  58. Tumor Microenvironment: Progression, Therapy and Prevention
    Yves DeClerck; Fiscal Year: 2007
    ..Plenary sessions will focus on Gene Expression Regulation in the Tumor Microenvironment, Inflammatory Reactions in the Tumor Microenvironment, Immune Function in ..
  59. REGULATION OF INSULIN AND PANCREATIC GENE EXPRESSION
    Chris Nelson; Fiscal Year: 1993
    ..Pan-1 and 2 regulatory function will be studied by site-directed mutagenesis and functional assays employing immunological reagents in simplified cell culture experiments and cell-free extracts...
  60. Functional characters of microRNAs in T lymphocytes
    Marianthi Kiriakidou; Fiscal Year: 2009
    ..The effects of miRNAs in gene expression regulation are pleiotropic, miRNAs control cellular proliferation, apoptosis and development, although many of the ..
  61. A Novel Gene, WTH3, and Multidrug Resistance
    HAOPENG DUFFY; Fiscal Year: 2005
    ..2) to study the WTH3 gene's role on the MDR1 gene expression regulation pathway by; testing WTH3's effect on wild type, deleted and mutated MDRI promoter constructs using ..
  62. FUNCTIONS OF THE E. COLI DNAY AND DSY GENES
    James Walker; Fiscal Year: 1990
    ..Second, the mechanism of dnaY gene expression regulation will be determined, includig isolation of the dnaY repressor...