gene expression


Summary: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Top Publications

  1. pmc KEGG: kyoto encyclopedia of genes and genomes
    M Kanehisa
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 28:27-30. 2000
  2. ncbi Molecular portraits of human breast tumours
    C M Perou
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Nature 406:747-52. 2000
  3. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  4. ncbi Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations
    Michael W Pfaffl
    Physiology, FML Weihenstephan, Centre of Life and Food Science, Technical University of Munich, Germany
    Biotechnol Lett 26:509-15. 2004
  5. pmc The human genome browser at UCSC
    W James Kent
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Genome Res 12:996-1006. 2002
  6. pmc Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    Lei S Qi
    UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 152:1173-83. 2013
  7. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
  8. pmc Coding-sequence determinants of gene expression in Escherichia coli
    Grzegorz Kudla
    Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:255-8. 2009
  9. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
  10. pmc Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 134:341-52. 2008

Research Grants

Detail Information

Publications358 found, 100 shown here

  1. pmc KEGG: kyoto encyclopedia of genes and genomes
    M Kanehisa
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 28:27-30. 2000
    ..The KEGG databases are daily updated and made freely available (http://www.
  2. ncbi Molecular portraits of human breast tumours
    C M Perou
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Nature 406:747-52. 2000
    ..Here we have characterized variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals, using ..
  3. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  4. ncbi Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations
    Michael W Pfaffl
    Physiology, FML Weihenstephan, Centre of Life and Food Science, Technical University of Munich, Germany
    Biotechnol Lett 26:509-15. 2004
    The stability of standard gene expression is an elementary prerequisite for internal standardisation of target gene expression data and many so called housekeeping genes with assumed stable expression can exhibit either up- or down-..
  5. pmc The human genome browser at UCSC
    W James Kent
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Genome Res 12:996-1006. 2002
    ..The conceptual and technical framework of the browser, its underlying MYSQL database, and overall use are described. The web site currently serves over 50,000 pages per day to over 3000 different users...
  6. pmc Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    Lei S Qi
    UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 152:1173-83. 2013
    ..Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system...
  7. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
    ..We investigated whether microRNA profiles are associated with known prognostic factors in CLL...
  8. pmc Coding-sequence determinants of gene expression in Escherichia coli
    Grzegorz Kudla
    Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:255-8. 2009
    Synonymous mutations do not alter the encoded protein, but they can influence gene expression. To investigate how, we engineered a synthetic library of 154 genes that varied randomly at synonymous sites, but all encoded the same green ..
  9. pmc Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    T Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10869-74. 2001
    The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome...
  10. pmc Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution
    D Allan Drummond
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 134:341-52. 2008
    Strikingly consistent correlations between rates of coding-sequence evolution and gene expression levels are apparent across taxa, but the biological causes behind the selective pressures on coding-sequence evolution remain controversial...
  11. ncbi In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    Lyubomir T Vassilev
    Department of Discovery Oncology, Roche Research Center, Hoffmann La Roche, Inc, Nutley, NJ 07110, USA
    Science 303:844-8. 2004
    ..These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice...
  12. ncbi Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    M S Longtine
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Yeast 14:953-61. 1998
    ..Thus, these plasmids should further facilitate the rapid analysis of gene function in S. cerevisiae...
  13. ncbi Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
    Carlos Lois
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Science 295:868-72. 2002
    ..We have also generated transgenic rats that express GFP at high levels, suggesting that this technique can be used to produce other transgenic animal species...
  14. pmc RNA-Seq gene expression estimation with read mapping uncertainty
    Bo Li
    Department of Computer Sciences, University of Wisconsin, Madison, WI 53706, USA
    Bioinformatics 26:493-500. 2010
    RNA-Seq is a promising new technology for accurately measuring gene expression levels. Expression estimation with RNA-Seq requires the mapping of relatively short sequencing reads to a reference genome or transcript set...
  15. pmc WebGestalt: an integrated system for exploring gene sets in various biological contexts
    Bing Zhang
    Graduate School in Genome Science and Technology, University of Tennessee Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Nucleic Acids Res 33:W741-8. 2005
    ..Exploration of all the 48 gene sets using WebGestalt is available for the public at
  16. pmc Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
    Mark H Chin
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 5:111-23. 2009
    ..A study of gene expression profiles of mouse and human ESCs and iPSCs suggests that, while iPSCs are quite similar to their embryonic ..
  17. pmc Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
    J Raphael Gibbs
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000952. 2010
    ..We believe these data, which we have made publicly available, will provide a critical step toward understanding the biological effects of genetic variation...
  18. doi The Immunological Genome Project: networks of gene expression in immune cells
    Tracy S P Heng
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Nat Immunol 9:1091-4. 2008
    ..The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression and regulatory networks in all immune cells...
  19. pmc Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Mol Cancer 5:67. 2006
    ..The gene expression and the drug resistance property of CD133 positive cancer stem cells, however, are still unknown.
  20. pmc Capturing heterogeneity in gene expression studies by surrogate variable analysis
    Jeffrey T Leek
    Department of Biostatistics, University of Washington, Seattle, Washington, USA
    PLoS Genet 3:1724-35. 2007
    ..been shown that genetic, environmental, demographic, and technical factors may have substantial effects on gene expression levels...
  21. pmc Multiple common variants for celiac disease influencing immune gene expression
    Patrick C A Dubois
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Nat Genet 42:295-302. 2010
    ..In an expression quantitative trait meta-analysis of 1,469 whole blood samples, 20 of 38 (52.6%) tested loci had celiac risk variants correlated (P < 0.0028, FDR 5%) with cis gene expression.
  22. pmc Pioneer transcription factors: establishing competence for gene expression
    Kenneth S Zaret
    Epigenetics Program, Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genes Dev 25:2227-41. 2011
    ..that detect regulatory sequences in the DNA and target the assembly of protein complexes that control gene expression. Yet much of the DNA in the eukaryotic cell is in nucleosomes and thereby occluded by histones, and can be ..
  23. pmc Functional organization of the transcriptome in human brain
    Michael C Oldham
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Neurosci 11:1271-82. 2008
    ..subventricular zone astrocytes, which are thought to function as neural stem cells in adults, have a distinct gene expression pattern relative to protoplasmic astrocytes...
  24. ncbi Genome-wide insertional mutagenesis of Arabidopsis thaliana
    Jose M Alonso
    Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:653-7. 2003
    ..Insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene...
  25. pmc Dissecting the regulatory architecture of gene expression QTLs
    Daniel J Gaffney
    Department of Human Genetics, University of Chicago, 920 E58th Street, Chicago, IL 60637, USA
    Genome Biol 13:R7. 2012
    ..Using the HapMap lymphoblastoid cell lines, we combine 1000 Genomes genotypes and an extensive catalogue of human functional elements to investigate the biological mechanisms that eQTLs perturb...
  26. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
    ..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
  27. ncbi Green fluorescent protein as a marker for gene expression
    M Chalfie
    Department of Biological Sciences, Columbia University, New York, NY 10027
    Science 263:802-5. 1994
    ..Because exogenous substrates and cofactors are not required for this fluorescence, GFP expression can be used to monitor gene expression and protein localization in living organisms.
  28. pmc High-resolution analysis of parent-of-origin allelic expression in the mouse brain
    Christopher Gregg
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 329:643-8. 2010
    ..We observed a preferential maternal contribution to gene expression in the developing brain and a major paternal contribution in the adult brain...
  29. pmc Nature, nurture, or chance: stochastic gene expression and its consequences
    Arjun Raj
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 135:216-26. 2008
    b>Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels...
  30. ncbi Quantitative real-time RT-PCR data analysis: current concepts and the novel "gene expression's CT difference" formula
    Jan H Schefe
    Center for Cardiovascular Research CCR Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115, Berlin, Germany
    J Mol Med (Berl) 84:901-10. 2006
    ..This concept is based on a novel formula for the calculation of relative gene expression ratios, termed GED (Gene Expression's CT Difference) formula...
  31. doi The SR protein family of splicing factors: master regulators of gene expression
    Jennifer C Long
    Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH42XU, UK
    Biochem J 417:15-27. 2009
    ..Here, we will review the current literature to demonstrate how SR proteins are emerging as one of the master regulators of gene expression.
  32. ncbi Cell biology of the glomerular podocyte
    Hermann Pavenstadt
    Division of Nephrology, Department of Medicine, University Hospital Freiburg, Freiburg, Germany
    Physiol Rev 83:253-307. 2003
    ..This review integrates our recent physiological and molecular understanding of the role of podocytes during the maintenance and failure of the glomerular filtration barrier...
  33. doi Epigenetic regulation of gene expression in physiological and pathological brain processes
    Johannes Graff
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139, USA
    Physiol Rev 91:603-49. 2011
    ..Clearly, the brain contains an epigenetic "hotspot" with a unique potential to not only better understand its most complex functions, but also to treat its most vicious diseases...
  34. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    We have developed a method for temporal and regional gene expression targeting (TARGET) in Drosophila and show the simultaneous spatial and temporal rescue of a memory defect...
  35. pmc Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
    M D Gomes
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:14440-5. 2001
    ..Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases...
  36. doi A gene expression atlas of the model legume Medicago truncatula
    Vagner A Benedito
    Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Plant J 55:504-13. 2008
    ..To enhance its value as a model, we have generated a gene expression atlas that provides a global view of gene expression in all major organ systems of this species, with special ..
  37. pmc New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits
    Fumitaka Osakada
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 71:617-31. 2011
    ..receptor for inactivation by ligand application; and rtTA, ER(T2)CreER(T2), or FLPo, for control of gene expression. These new tools allow neurons targeted on the basis of their connectivity to have their function assayed or ..
  38. pmc Rapid turnover of long noncoding RNAs and the evolution of gene expression
    Claudia Kutter
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS Genet 8:e1002841. 2012
    ..of intergenic lncRNA loci have been gained or lost since the last common ancestor of mouse and rat, and they predict that such rapid transcriptional turnover contributes to the evolution of tissue- and lineage-specific gene expression.
  39. pmc Global and local architecture of the mammalian microRNA-transcription factor regulatory network
    Reut Shalgi
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Comput Biol 3:e131. 2007
    microRNAs (miRs) are small RNAs that regulate gene expression at the posttranscriptional level...
  40. ncbi Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant
    P P Cherepanov
    Universitat Oldenburg, Germany
    Gene 158:9-14. 1995
    ..This system was applied in the construction of an E. coli endA deletion mutation which can be transduced by P1 to the genetic background of interest using TcR as a marker. The transductant can then be freed of the TcR if required...
  41. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..miRNAs) are a class of regulatory RNAs of approximately 22 nucleotides that post-transcriptionally regulate gene expression. Increasing evidence points to the potential role of miRNAs in various biological processes...
  42. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
    ..A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively...
  43. pmc Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line
    Philip J Reeves
    Departments of Biology and Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:13419-24. 2002
  44. doi Mammalian genes are transcribed with widely different bursting kinetics
    David M Suter
    Department of Molecular Biology, Sciences III, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Science 332:472-4. 2011
    ..Our analysis demonstrated that bursting kinetics are highly gene-specific, reflecting refractory periods during which genes stay inactive for a certain time before switching on again...
  45. pmc Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    M M Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Nature 359:693-9. 1992
    ..TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions...
  46. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..b>Gene expression analysis of IL-23-driven autoreactive T cells identified a unique expression pattern of proinflammatory ..
  47. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
    ..Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man...
  48. ncbi Toll-like receptors stimulate human neutrophil function
    Fumitaka Hayashi
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, USA
    Blood 102:2660-9. 2003
    ..Finally, using quantitative polymerase chain reaction (QPCR), we demonstrate a chemokine expression profile that suggests that TLR-stimulated neutrophils recruit innate, but not acquired, immune cells to sites of infection...
  49. ncbi Generalized lacZ expression with the ROSA26 Cre reporter strain
    P Soriano
    Nat Genet 21:70-1. 1999
  50. pmc The role of miRNAs in regulating gene expression networks
    Allan M Gurtan
    David H Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA Electronic address
    J Mol Biol 425:3582-600. 2013
    MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome...
  51. ncbi FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex
    Mitsutomo Abe
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 309:1052-6. 2005
    ..FT may represent a long-distance signal in flowering...
  52. pmc Single-RNA counting reveals alternative modes of gene expression in yeast
    Daniel Zenklusen
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Struct Mol Biol 15:1263-71. 2008
    Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude. How precisely the transcription machinery fulfills this task is not known...
  53. pmc Sex-specific and lineage-specific alternative splicing in primates
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 20:180-9. 2010
    Comparative studies of gene regulation suggest an important role for natural selection in shaping gene expression patterns within and between species...
  54. pmc Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy
    Hongqing Du
    RNA Center, Department of Molecular, Cell and Developmental Biology, Sinsheimer Labs, University of California, Santa Cruz, California, USA
    Nat Struct Mol Biol 17:187-93. 2010
    ..These findings reveal unanticipated similarities between DM1 and other muscular dystrophies...
  55. doi Genome and gene duplications and gene expression divergence: a view from plants
    Yupeng Wang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Ann N Y Acad Sci 1256:1-14. 2012
    ..Evolutionary consequences of gene duplication, often studied through analyzing gene expression divergence, have enhanced understanding of the biological significance of different mechanisms of gene ..
  56. doi Comparative transcriptomics of three Poaceae species reveals patterns of gene expression evolution
    Rebecca M Davidson
    Department of Plant Biology, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant J 71:492-502. 2012
    ..To gain an understanding of the genome-wide patterns of evolution of gene expression across reproductive tissues, we employed a sequence-based approach to compare analogous transcriptomes in ..
  57. doi Studying and modelling dynamic biological processes using time-series gene expression data
    Ziv Bar-Joseph
    Lane Center for Computational Biology and Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Nat Rev Genet 13:552-64. 2012
    ..The most abundant source of information regarding such dynamic activity is time-series gene expression data...
  58. pmc Gene expression drives local adaptation in humans
    Hunter B Fraser
    Department of Biology, Stanford University, Stanford, California 94305, USA
    Genome Res 23:1089-96. 2013
    The molecular basis of adaptation--and, in particular, the relative roles of protein-coding versus gene expression changes--has long been the subject of speculation and debate...
  59. pmc Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1001317. 2011
    Family studies of individual tissues have shown that gene expression traits are genetically heritable...
  60. pmc Comparing protein abundance and mRNA expression levels on a genomic scale
    Dov Greenbaum
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Genome Biol 4:117. 2003
    ..We also merge many of the available yeast protein-abundance datasets, using the resulting larger 'meta-dataset' to find correlations between protein and mRNA expression, both globally and within smaller categories...
  61. pmc Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    Tsung Cheng Chang
    The McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 26:745-52. 2007
    ..Expression of miR-34a causes dramatic reprogramming of gene expression and promotes apoptosis...
  62. ncbi Cancer/testis antigens, gametogenesis and cancer
    Andrew J G Simpson
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 5:615-25. 2005
  63. pmc Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process
    Uma R Chandran
    Departmental of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    BMC Cancer 7:64. 2007
    ..Understanding the differences in the biology of metastatic and organ confined primary tumors is essential for developing new prognostic markers and therapeutic targets...
  64. pmc Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
    Diabetes 57:3239-46. 2008
    ..To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity...
  65. ncbi PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    Cheryl L Day
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nature 443:350-4. 2006
    ..Moreover, this pathway of reversible T-cell impairment provides a potential target for enhancing the function of exhausted T cells in chronic HIV infection...
  66. ncbi A pancreatic islet-specific microRNA regulates insulin secretion
    Matthew N Poy
    Laboratory of Metabolic Diseases and Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 432:226-30. 2004
    MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational repression...
  67. pmc Faster-X evolution of gene expression in Drosophila
    Richard P Meisel
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Genet 8:e1003013. 2012
    ..Drosophila species and found that the expression levels of X-linked genes also diverge faster than autosomal gene expression, similar to the "faster-X" effect often observed in DNA sequence evolution...
  68. pmc Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
    Aaron M Cypess
    Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 19:635-9. 2013
    ..In this study, we isolated anatomically defined neck fat from adult human volunteers and compared its gene expression, differentiation capacity and basal oxygen consumption to different mouse adipose depots...
  69. ncbi Fate of the mammalian cardiac neural crest
    X Jiang
    Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
    Development 127:1607-16. 2000
  70. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  71. pmc A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues
    Athma A Pai
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1001316. 2011
    ..DNA by methylation is an important epigenetic mechanism that affects the spatial and temporal regulation of gene expression. Methylation patterns have been described in many contexts within and across a range of species...
  72. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  73. pmc ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells
    Zhengqing Ouyang
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 106:21521-6. 2009
    ..Compared with traditional methods, our approach not only offers higher power in predicting gene expression from ChIP-Seq data but also provides a way to capture cooperation among regulators...
  74. ncbi p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 398:714-8. 1999
    ..Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis...
  75. pmc Enhancer function: new insights into the regulation of tissue-specific gene expression
    Chin Tong Ong
    Department of Biology, Emory University, 1510 Clifton Road, NE Atlanta, Georgia 30322, USA
    Nat Rev Genet 12:283-93. 2011
    Enhancer function underlies regulatory processes by which cells establish patterns of gene expression. Recent results suggest that many enhancers are specified by particular chromatin marks in pluripotent cells, which may be modified ..
  76. ncbi Androgen receptor in prostate cancer
    Cynthia A Heinlein
    George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
    Endocr Rev 25:276-308. 2004
    ..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
  77. ncbi Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road Room G211, Atlanta, GA 30322, USA
    Immunity 27:670-84. 2007
    ..Thus, functional exhaustion is probably due to both active suppression and passive defects in signaling and metabolism. These results provide a framework for designing rational immunotherapies during chronic infections...
  78. doi A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine
    Daniëlle Haenen
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr 143:274-83. 2013
    ..Cecal and colonic SCFA concentrations were significantly greater in RS-fed pigs, and cecal gene expression of monocarboxylate transporter 1 (SLC16A1) and glucagon (GCG) was induced by RS...
  79. doi Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
    Vandana Kalia
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunity 32:91-103. 2010
    ..Consistent with this, sustained IL-2 receptor signaling during expansion drove terminal-effector differentiation. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal-effector differentiation...
  80. ncbi A genome-wide association study of global gene expression
    Anna L Dixon
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK
    Nat Genet 39:1202-7. 2007
    We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma...
  81. doi The critical role of RNA processing and degradation in the control of gene expression
    Cecilia M Arraiano
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127, 2781 901 Oeiras, Portugal
    FEMS Microbiol Rev 34:883-923. 2010
    ..Furthermore, RNA degradation mechanisms have shown to be determinant for the post-transcriptional control of gene expression. RNases mediate the processing, decay and quality control of RNA...
  82. pmc Evaluating gene expression in C57BL/6J and DBA/2J mouse striatum using RNA-Seq and microarrays
    Daniel Bottomly
    Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e17820. 2011
    ..microarray probes are based solely on this B6 reference sequence, making their application for gene expression profiling comparisons across mouse strains dubious due to their allelic sequence differences, including ..
  83. pmc RiceXPro: a platform for monitoring gene expression in japonica rice grown under natural field conditions
    Yutaka Sato
    Genome Resource Center, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Nucleic Acids Res 39:D1141-8. 2011
    ..We constructed a gene expression database (RiceXPro, URL: http://ricexpro.dna.affrc.go...
  84. ncbi Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy
    Yan Ping Yu
    University of Pittsburgh Cancer Institute and Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Oncol 22:2790-9. 2004
    ..Identification of the genes and patterns of gene expression will provide a more cohesive picture of prostate cancer biology.
  85. pmc A battery of transcription factors involved in the regulation of secondary cell wall biosynthesis in Arabidopsis
    Ruiqin Zhong
    Department of Plant Biology, University of Georgia, Athens, Georgia 30602, USA
    Plant Cell 20:2763-82. 2008
  86. pmc MicroRNAs can generate thresholds in target gene expression
    Shankar Mukherji
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 43:854-9. 2011
    MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner...
  87. pmc Paucity of genes on the Drosophila X chromosome showing male-biased expression
    Michael Parisi
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 8028, USA
    Science 299:697-700. 2003
    ..We examined global gene expression in Drosophila melanogaster and report a dramatic underrepresentation of X-chromosome genes showing high ..
  88. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  89. pmc Role of AMP-activated protein kinase in mechanism of metformin action
    G Zhou
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Clin Invest 108:1167-74. 2001
    ..Activation of AMPK provides a unified explanation for the pleiotropic beneficial effects of this drug; these results also suggest that alternative means of modulating AMPK should be useful for the treatment of metabolic disorders...
  90. ncbi Identification of virus-encoded microRNAs
    Sebastien Pfeffer
    Laboratory of RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, Box 186, New York, NY 10021, USA
    Science 304:734-6. 2004
    ..Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.
  91. pmc The UCSC Genome Browser Database: update 2006
    A S Hinrichs
    Center for Biomolecular Science and Engineering, School of Engineering, University of California Santa Cruz UCSC, Santa Cruz, CA 95064, USA
    Nucleic Acids Res 34:D590-8. 2006
    ..These tools are highly integrated and provide many hyperlinks to other databases and websites. The GBD, browsing tools, downloadable data files and links to documentation and other information can be found at
  92. pmc Is my network module preserved and reproducible?
    Peter Langfelder
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
    PLoS Comput Biol 7:e1001057. 2011
    ..Data, R software and accompanying tutorials can be downloaded from the following webpage:
  93. ncbi Protein production by auto-induction in high density shaking cultures
    F William Studier
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Protein Expr Purif 41:207-34. 2005
    ..Selenomethionine labeling was equally efficient in the commonly used methionine auxotroph B834(DE3) (found to be metE) or the prototroph BL21(DE3)...
  94. ncbi Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    T Miyashita
    La Jolla Cancer Research Foundation, California 92037
    Cell 80:293-9. 1995
    ..Taken together, the results suggest that bax is a p53 primary-response gene, presumably involved in a p53-regulated pathway for induction of apoptosis...
  95. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
  96. pmc Diagnosis of multiple cancer types by shrunken centroids of gene expression
    Robert Tibshirani
    Department of Health, Research and Policy, and Statistics, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:6567-72. 2002
    We have devised an approach to cancer class prediction from gene expression profiling, based on an enhancement of the simple nearest prototype (centroid) classifier...
  97. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  98. pmc Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum
    María J López-Barragán
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    BMC Genomics 12:587. 2011
    ..Antisense transcripts have widely been reported in P. falciparum; however, the extent and pattern of antisense transcripts in different developmental stages remain largely unknown...
  99. pmc Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
    P Moi
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita di Cagliari, Italy
    Proc Natl Acad Sci U S A 91:9926-30. 1994
    ..In this respect, Nrf2 contains a powerful acidic activation domain that may participate in the transcriptional stimulation of beta-globin genes...
  100. pmc An integrative genomics approach to infer causal associations between gene expression and disease
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington 98109, USA
    Nat Genet 37:710-7. 2005
    ..Ordering gene expression traits relative to one another and relative to other complex traits is achieved by systematically testing ..

Research Grants78

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..We will develop computational algorithms that integrate genotype, gene expression and phenotype data to construct models that describe how sequence variation perturbs the regulatory network, ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  4. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Brn3a and Islet1, and have shown these factors to be "master regulators" of sensory neuron development and gene expression. Mice lacking Brn3a exhibit abnormal sensory axon growth, fail to develop proprioceptors, and have a profound ..
  5. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..Therefore we predict that hormone alteration may regulate the HSV-1 gene expression during reactivation...
  6. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..the RCT system during regression of the primate CL, and in vitro studies will identify genome-wide changes in gene expression of the primate CL induced by activation of both or individual LXR isoforms...
  7. Carole R Mendelson; Fiscal Year: 2016
    ..for epigenetic and genetic changes associated with developmental, hormonal and O2 regulation of SP-A gene expression in fetal lung...
  8. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..Fischer 344 rats of varying ages from two different laboratories to determine the variability of Differential Gene Expression (DGE) in liver...
  9. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013 OPN-FL and OPN-L in terms of cell adhesion, cell proliferation, apoptosis, protein phosphorylation, gene expression and cytokine production...
  10. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..Fischer 344 rats of varying ages from two different laboratories to determine the variability of Differential Gene Expression (DGE) in liver...
  11. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..Using RNA interference (RNAi) to down regulate a target gene expression, we have previously demonstrated that a multi-targeted siRNA cocktail targeting these genes can accelerate ..
  12. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Although PRDA/f76-deficient BAT exhibits a dysregulated pattern of gene expression, it retains significant brown adipose attributes and is still recognizable as BAT...
  13. Bandana Chatterjee; Fiscal Year: 2016
    ..with androgen or D3 or androgen+D3;2), interplay of Alien and prohibitin with WSTF and E47 in regulating E2F1 gene expression;3), roles of endogenous WSTF/E47/Alien/prohibitin in androgen-stimulated and D3-inhibited prostate cancer ..
  14. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..other proteins which can 'read'these marks and lead to cell-type and environmentally appropriate gene expression or repression...
  15. ENEIQUE A MESRI; Fiscal Year: 2016
    ..Interestingly, we also found that NAC inibited VEGF, c-myc and viral gene expression in the mECK36 tumors through a mechanism involving platelet derived growth factor (PDGF) receptor and ligand ..
  16. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..suggest that Sply/SPL is required for normal AKT signaling, protein translation, myoblast fusion, myoblast gene expression and control of autophagy...
  17. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..Preliminary studies conducted by our laboratory indicate that dietary MR also decreases SCD1 gene expression in the hypothalamus of the brain and liver...
  18. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..3) Identify changes in molecular signaling pathways (e.g., sirtuin pathway gene expression and target acetylation, IGF-1/insulin axis, PGC-1, nuclear factors) potentially mediating changes in ..
  19. Neil W Kowall; Fiscal Year: 2014
    ..We will measure LSD1 gene expression and activity levels using Real-Time PCR, Western blotting, immunofluorescent staining and by assessing ..
  20. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Discern the extent to which PMN function is impaired via effects of Ft virulence determinants on neutrophil gene expression and key intracellular signaling pathways...
  21. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..g. non-synonymous coding SNPs and b) to mask striatal gene expression data...
  22. Michael Demetriou; Fiscal Year: 2014
    ..of macromolecular complexes on the cell surface, and in this capacity, acts upstream of signaling and gene expression to influence cell growth, differentiation and disease states...
  23. Bayar Thimmapaya; Fiscal Year: 2016
    ..b>Gene expression profiling revealed that Med1 upregulates many genes that are important for lipogenesis and gluconeogenesis...
    Maureen J Charron; Fiscal Year: 2010
    ..and offspring genetics (hemizygous lesion in peripheral glucose uptake, G4+/-) to alterations in hepatic gene expression and methylation related to the incidence of T2DM and Metabolic Syndrome will be measured...
  25. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..Since MYCN has been shown to activate ODC gene expression, we hypothesized that ODC and polyamines might play a role in MYCN-amplified NB tumorigenesis...
  26. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..There is no consensus on gene expression patterns linked to BPD &, hence, very little insight into underlying molecular mechanisms...
  27. Mark W Chapleau; Fiscal Year: 2015
    ..b>Gene expression of CGRP, CGRP receptor subunits, Ang-II receptors, and pro- and anti- oxidant molecules will be measured in ..
  28. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..when sustained activity may lead to myogenic fatigue- and hours to weeks -patterns that cause changes in gene expression and long-term adaptation-...
  29. Robert T Means; Fiscal Year: 2014 well as the anemia syndromes observed in patients and transgenic animals with abnormalities of hepcidin gene expression (discussed below), have led many to consider that it is the key to unlocking "the mysteries of ACD "...
  30. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..NF-?B stimulates gene expression of PRC proteins by recruiting IKK1 and PCAF to responsive promoters and derepressing SMRT (silencing mediator ..
  31. Trichothecene Toxicity and the Ribotoxic Stress Response
    James J Pestka; Fiscal Year: 2012
    ..ricin, Shiga toxin, anisomycin) induce proinflammatory gene expression and apoptosis in lymphoid tissues...
  32. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..Our recent findings demonstrate a key role for PerR-regulated gene expression in counteracting the phagocyte oxidative burst and a critical contribution to GAS adaptation in the host ..
  33. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..Recent work has led us to realize that the ability of these hnRNPs to alter steroid hormone-directed gene expression is not limited to their dominant-negative actions at the level of transcription...
  34. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..The regulation of EC-SOD in IPAH has not been investigated. It is now recognized that gene expression can be regulated by epigenetic modifications including cytosine methylation within the promoter region, ..
    Pi Wan Cheng; Fiscal Year: 2010
    ..Modulation of C2GnT-M gene expression can greatly affect the physicochemical properties of airway mucins and functions of airway mucus...
  36. Shervin Assassi; Fiscal Year: 2014
    ..Under their guidance, the candidate has published the largest gene expression profiling study in systemic sclerosis (SSc) to date. Dr. Jon E...
  37. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..Interestingly, the Cul3 and Rbx1 gene expression is coordinately induced with INrf2 in response to antioxidant raising questions if Cul3 and Rbx1 are part of ..
  38. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..HIV-induced neurodegeneration may result at least in part from changes in cellular gene expression induced by HIV-1 Tat in a variety of cell types including astrocytes and neurons...
  39. Schahram Akbarian; Fiscal Year: 2014
    ..of Setdb1 transgenic mice, and the transcriptional regulation of NMDA receptor subunit Grin2b, and other gene expression changes, and to uncover novel treatment strategies for affective disorders...
  40. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ..of mRNA from male and female animals treated with DNMT inhibitors or vehicle to categorize differential gene expression. Completion of these studies will provide novel insight into the mechanisms maintaining sex differences in ..
    Adrian R Krainer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pre-mRNA splicing is an essential step in gene expression. It involves precise excision of introns and joining of exons from primary transcripts in the nucleus to generate mature mRNA, the template ..
  42. Genomics of Antiviral Responses of Anopheles gambiae Against O'nyong-nyong Virus
    Young S Hong; Fiscal Year: 2010
    ..With this genome sequence available, An. gambiae offers a powerful model system to study gene expression profiles of mosquito vectors in response to viral infections at the genome level...
    Lisa M Salati; Fiscal Year: 2012
    ..In the course of our studies on mechanisms by which fatty acids regulate gene expression, we discovered that the rate of RNA splicing is inhibited in liver and primary hepatocytes by dietary ..
  44. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..affinity to both the glucocorticoid receptor and the mineralocorticoid receptor, thus regulating cochlear gene expression via immune suppression and ion homeostasis, respectively...
  45. DHAN V KALVAKOLANU; Fiscal Year: 2014
    ..A gene expression micro- array analysis in our lab identified several IFN regulated genes, whose expression required C/EBP-2...
  46. Jianming Qiu; Fiscal Year: 2016
    ..e., EPCs ex vivo-expanded under hypoxic conditions for B19V in this application. ..
  47. DEBROSKI R HERBERT; Fiscal Year: 2016
    ..that facilitate careful mechanistic dissection of the cell-lineage specific importance of TH2 associated gene expression. Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse ..
  48. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..IRI is associated with early increased endothelial permeability and edema and later, changes in gene expression, resulting in inflammation...
  49. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..The expression of both virulence factors is regulated by ToxT, the paramount regulator of virulence gene expression in Vibrio cholerae...
  50. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013 to alter the methylation status of MUC5AC CpG islands and that this status is inversely related MUC5AC gene expression. Based on these results, we hypothesize that epigenetic changes, especially changes in DNA methylation status,..
  51. Swati Joshi-Barve; Fiscal Year: 2014
    ..showing that non-toxic concentrations of acrolein significantly down-regulate IFN1 signaling and antiviral gene expression in vitro (cultured human hepatic cells) and in vivo (mice)...
  52. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ..Aim 3 examines the role of DNA methylation in regulating apob gene expression as a potential mechanism of betaine action by assessment of global and promoter DNA hypomethylation and ..
  53. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..ISF BK and kallikrein gene expression, as well as increased MCs and chymase activity, are increased at both early and late stages of VO, suggesting ..
  54. John S Davis; Fiscal Year: 2014
    ..a variety of approaches [expression or mutant molecules, siRNA knockdown, immuno-localization, enzyme assays, gene expression, protein degradation, protein-protein and protein-DNA interactions, ChIP analysis] to identify novel ..
  55. MATTHEW PETER COGGINS; Fiscal Year: 2014
    ..In Specific Aim 2, we will investigate the signaling mechanisms and the patterns of altered gene expression in the IKKB deleted mice which relate to the observed phenotype...
  56. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..mutation induce lethal ventricular tachycardia and whether TS mutation alters proliferation, differentiation, gene expression, contractility and ultra-structures in human CMs to uncover further molecular and cellular mechanisms that ..
  57. Masayuki Yazawa; Fiscal Year: 2015
    ..mutation induce lethal ventricular tachycardia and whether TS mutation alters proliferation, differentiation, gene expression, contractility and ultra-structures in human CMs to uncover further molecular and cellular mechanisms that ..
  58. DAVID MATTHEW KELLER; Fiscal Year: 2016
    ..also promotes long-term changes in [unreadable]-cell function, growth, and survival through regulation of gene expression (Hinke et al., 2004), not all of which are completely understood...
  59. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..This is consistent with the hypothesis that abnormal target-gene expression ICSBP-deficient cells predisposes to acquisition of additional genetic mutations, leading to differentiation ..
  60. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..D1 (AT-NPD1), inhibit ischemia-reperfusion mediated leukocyte infiltration and pro-inflammatory gene expression, as well as elicit neuroprotection in the stroke penumbra...
  61. Subhash C Pandey; Fiscal Year: 2014
    ..miRNAs are small non-coding RNAs that have been shown to regulate gene expression at the post- translational level...
  62. Mahin D Maines; Fiscal Year: 2015
    ..signaling pathways that regulate glucose uptake, cell growth, apoptosis and stress-response gene expression (c-fos, c-jun, HO-1, CREB/ATF- 2)...
  63. Alvaro Puga; Fiscal Year: 2015
    ..These changes inhibit recruitment of RNA polymerase II to the Cyp1a1 promoter, block BaP-inducible gene expression and stimulate the formation of BPDE-DNA adducts...
  64. NIH Director's Pioneer Award
    Karl Deisseroth; Fiscal Year: 2009
    ..abstract_text> ..
  65. Serotonin, Autism, and investigating cell types for CNS disorders.
    Joseph D Dougherty; Fiscal Year: 2010
    ..Daniel Geschwind. His dissertation entailed gene expression profiling to identify neural stem and progenitor cell genes, followed by anatomical and functional studies of ..
  66. DNA Methylation Profiling of Chronic Pain
    Andreas S Beutler; Fiscal Year: 2010 applicant): DNA cytosine methylation is a keeper of "cellular memory", stable and able to (co-)determine gene expression. De novo cytosine methylation occurs in development and, if activated inappropriately in the adult, can cause ..
  67. Peripheral Biomarkers in Familial Alzheimer's Disease
    Paul Coleman; Fiscal Year: 2009
    ..profile of easily obtained samples raises the question;can we distinguish preclinical AD on the basis of gene expression profiles of peripheral blood leukocytes? To answer this question requires obtaining blood samples from a ..
    Terry W Osborn; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): AbaStar MDx RFA-OD-09-009, (R43), SBIR - Gene Expression Exon Array Biomarkers to Diagnose Schizophrenia Project Summary/Abstract This application RFA-OD-09-009, addresses Recovery Act Limited ..
  69. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    MARK DANIEL contact PEGRAM; Fiscal Year: 2010
    ..We therefore hypothesize that gene expression changes will be identified in locally advanced triple negative breast cancer patients which are associated ..
    Joseph Glorioso; Fiscal Year: 2000
    ..This application describes the use of HSV mutants to investigate HSV gene expression during latency. Mutant viruses with as many as three IE genes have been deleted...
    Nigel Fraser; Fiscal Year: 2007 of HSV latency to study physical state of the latent viral genome, and to initiate studies on viral gene expression during latency. From our data, we have formulated models for the mechanism of HSV-1 latency...
  72. Development of a human Oct-4 gene-targeted reporter cell line
    GREGORY LENO; Fiscal Year: 2010
    ..will be validated by demonstrating a significant correlation between reporter activity and endogenous Oct-4 gene expression following treatment with commercially available epi-drugs with which NuPotential has shown up-regulation of ..
  73. Prediction of Lupus Outcome by Gene Expression Patterns
    Robert Winchester; Fiscal Year: 2006
    Support is sought for performing mechanistic studies to define the gene expression profiles of glomeruli isolated from biopsy sections of lupus glomerulonephritis with the overall goals of determining whether the glomerular gene ..
  74. Activation of HTLV1 Gene Expression and Oncogenesis
    Arnold Rabson; Fiscal Year: 2006 the level of the individual infected cell, in which cellular regulatory mechanisms could influence viral gene expression. Recent studies from our laboratory have demonstrated that HTLV1 infection of human T cell lines can be ..
    KEVIN SARGE; Fiscal Year: 1999
    ..Each spermatogenic cell type displays unique patterns of gene expression which ensure the production of proteins important for the specialized functions of these cells...
    Anuradha Ray; Fiscal Year: 2000
    ..Also, corticosteroids which have been a mainstay in asthma therapy, inhibit IL-5 gene expression. The molecular events involved in the activationof IL-5 gene transcription in T helper subtype 2 (Th2) cells, ..
  77. Stringent control of virulence gene expression in Pseudomonas aeruginosa
    Martin Schuster; Fiscal Year: 2009
    ..One such response is the induction of virulence gene expression. Many of these virulence genes are controlled by quorum sensing (QS), a mechanism that allows cell-density-..
  78. Leptin Production and Action in Adipocytes
    Yiying Zhang; Fiscal Year: 2007
    ..Aim I is to investigate the molecular mechanisms responsible for the close correlation between leptin gene expression, adipocyte size and the metabolic status of adipocytes...