evolution

Summary

Summary: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.

Top Publications

  1. ncbi APE: Analyses of Phylogenetics and Evolution in R language
    Emmanuel Paradis
    Laboratoire de Paléontologie, Paléobiologie and Phylogénie, Institut des Sciences de l Evolution, Universite Montpellier II, F 34095 Montpellier cedex 05, France
    Bioinformatics 20:289-90. 2004
  2. pmc Relaxed phylogenetics and dating with confidence
    Alexei J Drummond
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e88. 2006
  3. ncbi Generalized linear mixed models: a practical guide for ecology and evolution
    Benjamin M Bolker
    Department of Botany and Zoology, University of Florida, Gainesville, FL 32611 8525, USA
    Trends Ecol Evol 24:127-35. 2009
  4. pmc Five rules for the evolution of cooperation
    Martin A Nowak
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, and Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    Science 314:1560-3. 2006
  5. pmc Evolution of mammals and their gut microbes
    Ruth E Ley
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 320:1647-51. 2008
  6. ncbi Host-microbe interactions: shaping the evolution of the plant immune response
    Stephen T Chisholm
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 124:803-14. 2006
  7. doi Horizontal gene transfer in eukaryotic evolution
    Patrick J Keeling
    Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z, Canada
    Nat Rev Genet 9:605-18. 2008
  8. pmc DNA transposons and the evolution of eukaryotic genomes
    CEDRIC FESCHOTTE
    Department of Biology, University of Texas, Arlington, TX 76019, USA
    Annu Rev Genet 41:331-68. 2007
  9. doi Genomics and evolution of heritable bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Genet 42:165-90. 2008
  10. doi Maximum likelihood inference of geographic range evolution by dispersal, local extinction, and cladogenesis
    Richard H Ree
    Department of Botany, Field Museum of Natural History, Chicago, Illinois 60605, USA
    Syst Biol 57:4-14. 2008

Detail Information

Publications308 found, 100 shown here

  1. ncbi APE: Analyses of Phylogenetics and Evolution in R language
    Emmanuel Paradis
    Laboratoire de Paléontologie, Paléobiologie and Phylogénie, Institut des Sciences de l Evolution, Universite Montpellier II, F 34095 Montpellier cedex 05, France
    Bioinformatics 20:289-90. 2004
    Analysis of Phylogenetics and Evolution (APE) is a package written in the R language for use in molecular evolution and phylogenetics...
  2. pmc Relaxed phylogenetics and dating with confidence
    Alexei J Drummond
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e88. 2006
    ..From these we conclude that our method is phylogenetically more accurate and precise than the traditional unrooted model while adding the ability to infer a timescale to evolution.
  3. ncbi Generalized linear mixed models: a practical guide for ecology and evolution
    Benjamin M Bolker
    Department of Botany and Zoology, University of Florida, Gainesville, FL 32611 8525, USA
    Trends Ecol Evol 24:127-35. 2009
    ..of research on GLMMs in the last decade has generated considerable uncertainty for practitioners in ecology and evolution. Despite the availability of accurate techniques for estimating GLMM parameters in simple cases, complex GLMMs ..
  4. pmc Five rules for the evolution of cooperation
    Martin A Nowak
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, and Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    Science 314:1560-3. 2006
    Cooperation is needed for evolution to construct new levels of organization. Genomes, cells, multicellular organisms, social insects, and human society are all based on cooperation...
  5. pmc Evolution of mammals and their gut microbes
    Ruth E Ley
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 320:1647-51. 2008
    ....
  6. ncbi Host-microbe interactions: shaping the evolution of the plant immune response
    Stephen T Chisholm
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 124:803-14. 2006
    The evolution of the plant immune response has culminated in a highly effective defense system that is able to resist potential attack by microbial pathogens...
  7. doi Horizontal gene transfer in eukaryotic evolution
    Patrick J Keeling
    Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z, Canada
    Nat Rev Genet 9:605-18. 2008
    ..Horizontal gene transfer (HGT; also known as lateral gene transfer) has had an important role in eukaryotic genome evolution, but its importance is often overshadowed by the greater prevalence and our more advanced understanding of gene ..
  8. pmc DNA transposons and the evolution of eukaryotic genomes
    CEDRIC FESCHOTTE
    Department of Biology, University of Texas, Arlington, TX 76019, USA
    Annu Rev Genet 41:331-68. 2007
    ..Finally, we highlight how the distinctive biological features of DNA transposons have contributed to shape genome architecture and led to the emergence of genetic innovations in different eukaryotic lineages...
  9. doi Genomics and evolution of heritable bacterial symbionts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Genet 42:165-90. 2008
    ..In addition, insect symbionts provide some of the extremes of cellular genomes, including the smallest and the fastest evolving, raising new questions about the limits of evolution of life.
  10. doi Maximum likelihood inference of geographic range evolution by dispersal, local extinction, and cladogenesis
    Richard H Ree
    Department of Botany, Field Museum of Natural History, Chicago, Illinois 60605, USA
    Syst Biol 57:4-14. 2008
    In historical biogeography, model-based inference methods for reconstructing the evolution of geographic ranges on phylogenetic trees are poorly developed relative to the diversity of analogous methods available for inferring character ..
  11. ncbi Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
    Eva Jablonka
    The Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv University, Tel Aviv 69978, Israel
    Q Rev Biol 84:131-76. 2009
    ..We conclude by exploring some of the consequences of epigenetic inheritance for the study of evolution, while also pointing to the importance of recognizing and understanding epigenetic inheritance for practical and ..
  12. ncbi Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
    Santiago F Elena
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas, 46022 Valencia, Spain
    Nat Rev Genet 4:457-69. 2003
    ..Now, a field of research has developed around the idea of using microorganisms to study evolution in action...
  13. ncbi Origins and evolution of the Western diet: health implications for the 21st century
    Loren Cordain
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Am J Clin Nutr 81:341-54. 2005
    ..The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization...
  14. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
    ..Here we propose a simple statistical test of the neutral protein evolution hypothesis based on a comparison of the number of amino-acid replacement substitutions to synonymous ..
  15. pmc Preservation of duplicate genes by complementary, degenerative mutations
    A Force
    Department of Biology, University of Oregon, Eugene, Oregon 97403, USA
    Genetics 151:1531-45. 1999
    The origin of organismal complexity is generally thought to be tightly coupled to the evolution of new gene functions arising subsequent to gene duplication...
  16. ncbi DAMBE: software package for data analysis in molecular biology and evolution
    X Xia
    Bioinformatics Laboratory, Department of Ecology and Biodiversity, University of Hong Kong, Pokfulam Road, Hong Kong
    J Hered 92:371-3. 2001
    DAMBE (data analysis in molecular biology and evolution) is an integrated software package for converting, manipulating, statistically and graphically describing, and analyzing molecular sequence data with a user-friendly Windows 95/98/..
  17. ncbi A globally coherent fingerprint of climate change impacts across natural systems
    Camille Parmesan
    Integrative Biology, Patterson Laboratories 141, University of Texas, Austin, Texas 78712, USA
    Nature 421:37-42. 2003
    ..This suite of analyses generates 'very high confidence' (as laid down by the IPCC) that climate change is already affecting living systems...
  18. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....
  19. ncbi Toward automatic reconstruction of a highly resolved tree of life
    Francesca D Ciccarelli
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Science 311:1283-7. 2006
    ..For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor...
  20. ncbi Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles
    Pamela F Colosimo
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 307:1928-33. 2005
    ..EDA) signaling pathway plays a key role in evolutionary change in natural populations and that parallel evolution of stickleback low-plated phenotypes at most freshwater locations around the world has occurred by repeated ..
  21. ncbi Founding events in species invasions: genetic variation, adaptive evolution, and the role of multiple introductions
    K M Dlugosch
    Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Mol Ecol 17:431-49. 2008
    ..for loss of diversity in quantitative traits? Do invaders that have experienced strong bottlenecks show adaptive evolution? How do multiple introductions influence adaptation on a landscape scale? We reviewed studies of 80 species of ..
  22. ncbi Integrating animal temperament within ecology and evolution
    Denis Reale
    Canada Research Chair in Behavioural Ecology and Groupe de Recherche en Ecologie Comportementale et Animale, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Biol Rev Camb Philos Soc 82:291-318. 2007
    ..genetics, pharmacology, and animal husbandry, but relatively few studies have examined the ecology and evolution of temperament traits...
  23. ncbi Evolution of indirect reciprocity by image scoring
    M A Nowak
    Department of Zoology, University of Oxford, UK
    Nature 393:573-7. 1998
    Darwinian evolution has to provide an explanation for cooperative behaviour. Theories of cooperation are based on kin selection (dependent on genetic relatedness), group selection and reciprocal altruism...
  24. ncbi The delayed rise of present-day mammals
    Olaf R P Bininda-Emonds
    Lehrstuhl für Tierzucht, Technical University of Munich, 85354 Freising Weihenstephan, Germany
    Nature 446:507-12. 2007
    ....
  25. ncbi The locus of evolution: evo devo and the genetics of adaptation
    Hopi E Hoekstra
    Department of Organismic and Evolutionary Biology and The Museum of Comparative Zoology, Harvard University, 26 Oxford Street, Cambridge, Massachusetts 02138, USA
    Evolution 61:995-1016. 2007
    ..In addition, some forms of protein evolution can avoid the negative consequences of pleiotropy, most notably via gene duplication...
  26. pmc Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer
    Yingguang Frank Chan
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 327:302-5. 2010
    ....
  27. ncbi Perspective: Sign epistasis and genetic constraint on evolutionary trajectories
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1165-74. 2005
    ..Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection remains incomplete...
  28. ncbi Spatial structure often inhibits the evolution of cooperation in the snowdrift game
    Christoph Hauert
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
    Nature 428:643-6. 2004
    ..basis of spatial extensions of the Prisoner's Dilemma, it is widely accepted that spatial structure promotes the evolution of cooperation...
  29. doi Energy limitation as a selective pressure on the evolution of sensory systems
    Jeremy E Niven
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Exp Biol 211:1792-804. 2008
    b>Evolution of animal morphology, physiology and behaviour is shaped by the selective pressures to which they are subject...
  30. ncbi Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 317:86-94. 2007
    ..Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor...
  31. ncbi Bayesian inference of phylogeny and its impact on evolutionary biology
    J P Huelsenbeck
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 294:2310-4. 2001
    ....
  32. ncbi Evolution of indirect reciprocity
    Martin A Nowak
    Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 437:1291-8. 2005
    ..The evolution of cooperation by indirect reciprocity leads to reputation building, morality judgement and complex social ..
  33. pmc Evolution of the core and pan-genome of Streptococcus: positive selection, recombination, and genome composition
    Tristan Lefebure
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genome Biol 8:R71. 2007
    ..This study employs comparative evolutionary analyses of 26 Streptococcus genomes to yield an improved understanding of the relative roles of recombination and positive selection in pathogen adaptation to their hosts...
  34. ncbi Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    Leah E Cowen
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 309:2185-9. 2005
    Hsp90 is a molecular chaperone for many signal transducers and may influence evolution by releasing previously silent genetic variation in response to environmental change...
  35. ncbi Hsp90 as a capacitor of phenotypic variation
    Christine Queitsch
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 417:618-24. 2002
    ..Manipulating Hsp90's buffering capacity offers a tool for harnessing cryptic genetic variation and for elucidating the interplay between genotypes, environments and stochastic events in the determination of phenotype...
  36. pmc Sponge-associated microorganisms: evolution, ecology, and biotechnological potential
    Michael W Taylor
    Department of Microbial Ecology, University of Vienna, Althanstr 14, A 1090 Vienna, Austria
    Microbiol Mol Biol Rev 71:295-347. 2007
    ..We review the status of this important field, outlining the various approaches (e.g., cultivation, cell separation, and metagenomics) which have been employed to access the chemical wealth of sponge-microbe associations...
  37. pmc A simple rule for the evolution of cooperation on graphs and social networks
    Hisashi Ohtsuki
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Nature 441:502-5. 2006
    ..In this case, cooperation can evolve as a consequence of 'social viscosity' even in the absence of reputation effects or strategic complexity...
  38. ncbi The nature of human altruism
    Ernst Fehr
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 425:785-91. 2003
    ..Current gene-based evolutionary theories cannot explain important patterns of human altruism, pointing towards the importance of both theories of cultural evolution as well as gene-culture co-evolution.
  39. ncbi Experimental evolution of bet hedging
    Hubertus J E Beaumont
    New Zealand Institute for Advanced Study and Allan Wilson Centre for Molecular Ecology and Evolution, Massey University, Private Bag 102904, North Shore Mail Centre, North Shore City 0745, Auckland, New Zealand
    Nature 462:90-3. 2009
    ..Here we report the de novo evolution of bet hedging in experimental bacterial populations...
  40. doi Virulence evolution and the trade-off hypothesis: history, current state of affairs and the future
    S Alizon
    Department of Mathematics and Statistics, Queen s University, Kingston, Canada
    J Evol Biol 22:245-59. 2009
    ..We discuss the history of the study of virulence evolution and the development of theories towards the trade-off hypothesis in order to illustrate the context of the ..
  41. ncbi Genomic evolution of Hox gene clusters
    Derek Lemons
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 313:1918-22. 2006
    ..reduced, or expanded in many animals-findings that correlate with interesting morphological changes in evolution. Hox gene clusters also contain many noncoding RNAs, such as intergenic regulatory transcripts and ..
  42. ncbi Phenotypic plasticity in the interactions and evolution of species
    A A Agrawal
    Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, ON M5S 3B2, Canada
    Science 294:321-6. 2001
    ..The evolution of adaptive phenotypic plasticity has led to the success of organisms in novel habitats, and potentially ..
  43. ncbi GEIGER: investigating evolutionary radiations
    Luke J Harmon
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Bioinformatics 24:129-31. 2008
    ..GEIGER can carry out simulations, parameter estimation and statistical hypothesis testing. Additionally, GEIGER's simulation algorithms can be used to analyze the statistical power of comparative approaches...
  44. ncbi Living with the past: evolution, development, and patterns of disease
    Peter D Gluckman
    Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2 6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand
    Science 305:1733-6. 2004
    ..This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications...
  45. ncbi Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models
    Z Yang
    Department of Biology, University College London, England
    Mol Biol Evol 17:32-43. 2000
    ..in those steps and propose a new approximate method that takes into account two major features of DNA sequence evolution: transition/transversion rate bias and base/codon frequency bias...
  46. doi Convergent sequence evolution between echolocating bats and dolphins
    Yang Liu
    School of Life Sciences, East China Normal University, Shanghai 200062, China
    Curr Biol 20:R53-4. 2010
    Cases of convergent evolution - where different lineages have evolved similar traits independently - are common and have proven central to our understanding of selection...
  47. ncbi The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism
    E Virginia Armbrust
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 306:79-86. 2004
    ....
  48. pmc Antagonistic coevolution accelerates molecular evolution
    Steve Paterson
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Nature 464:275-8. 2010
    ..hypothesis proposes that coevolution of interacting species (such as hosts and parasites) should drive molecular evolution through continual natural selection for adaptation and counter-adaptation...
  49. pmc Modular networks and cumulative impact of lateral transfer in prokaryote genome evolution
    Tal Dagan
    Institut für Botanik III, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 105:10039-44. 2008
    ..of natural variation among prokaryotes, but the significance of its quantitative contribution to genome evolution is debated...
  50. ncbi Behavioral syndromes: an intergrative overiew
    Andrew Sih
    Department of Environmental Science and Policy, University of California, Davis 95616, USA
    Q Rev Biol 79:241-77. 2004
    ..Here, we present an integrative overview on the potential importance of behavioral syndromes in evolution and ecology...
  51. doi The puzzle of plastid evolution
    John M Archibald
    The Canadian Institute for Advanced Research, Program in Integrated Microbial Biodiversity, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Curr Biol 19:R81-8. 2009
    ..of the origin and spread of plastids remains an important yet elusive goal in the field of eukaryotic evolution. Combined with the discovery of new photosynthetic and non-photosynthetic protist lineages, the results of ..
  52. pmc Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
    Liam J Holt
    Departments of Physiology and Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Science 325:1682-6. 2009
    To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase Cdk1 in the budding yeast Saccharomyces cerevisiae...
  53. ncbi Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    Alexander R A Anderson
    Division of Mathematics, University of Dundee, Dundee, DD1 4HN, Scotland, UK
    Cell 127:905-15. 2006
    ..Thus, the genetic make-up of a cancer cell may realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces...
  54. doi Explaining evolution of plant communication by airborne signals
    Martin Heil
    Departamento de Ingeniería Genética CINVESTAV, Irapuato, Guanajuato, Mexico
    Trends Ecol Evol 25:137-44. 2010
    ..This information is crucial to understanding the ecology and evolution of plant communication via airborne cues.
  55. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..genes, male seminal fluid proteins (SFPs), and spermatogenesis genes show lineage-specific bursts of accelerated evolution and positive selection. SFP genes also show evidence of lineage-specific gene loss and/or gain...
  56. ncbi Altruistic punishment in humans
    Ernst Fehr
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 415:137-40. 2002
    ..These results suggest that future study of the evolution of human cooperation should include a strong focus on explaining altruistic punishment.
  57. ncbi Fingerprints of global warming on wild animals and plants
    Terry L Root
    Center for Environmental Science and Policy, Institute for International Studies, Stanford University, Stanford, California 94305, USA
    Nature 421:57-60. 2003
    ....
  58. pmc Copy number variation and evolution in humans and chimpanzees
    George H Perry
    School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona 85287, USA
    Genome Res 18:1698-710. 2008
    ..In particular, duplications and deletions of genes with inflammatory response and cell proliferation functions may have been fixed by positive selection and involved in the adaptive phenotypic differentiation of humans and chimpanzees...
  59. ncbi Flavonoids: a colorful model for the regulation and evolution of biochemical pathways
    Ronald Koes
    Department of Genetics, Institute for Molecular Biological Sciences, Vrije Universiteit, De Boelelaan 1085, 1081HV Amsterdam, The Netherlands
    Trends Plant Sci 10:236-42. 2005
    ..Moreover, because pigmentation is studied in a variety of species, it provides unique molecular insights into the evolution of biochemical pathways and regulatory networks.
  60. ncbi Evolution, consequences and future of plant and animal domestication
    Jared Diamond
    Department of Physiology, University of California Medical School, Los Angeles, 90095 1751, USA
    Nature 418:700-7. 2002
    ....
  61. ncbi Public information: from nosy neighbors to cultural evolution
    Etienne Danchin
    U P M C CNRS UMR7625, Bât A 7e étage Case 237, 7 quai Saint Bernard, 75252 Paris Cedex 05, France
    Science 305:487-91. 2004
    ..The use of public information is taxonomically widespread and can enhance fitness. Public information can lead to cultural evolution, which we suggest may then affect biological evolution.
  62. pmc Origins and evolution of eukaryotic RNA interference
    Svetlana A Shabalina
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Trends Ecol Evol 23:578-87. 2008
    ..of diverse eukaryotes available for comparison, the opportunity emerges for insights into the origin and evolution of RNA interference (RNAi). The miRNA repertoires of plants and animals appear to have evolved independently...
  63. ncbi Adaptive evolution in invasive species
    Peter J Prentis
    Australian Centre for Evolutionary Biology and Biodiversity, School of Earth and Environmental Sciences, University of Adelaide, North Terrace, South Australia 5005, Australia
    Trends Plant Sci 13:288-94. 2008
    ..Understanding the source of variation that contributes to adaptive evolution in invasive plants is important for predicting future invasion scenarios, identifying candidate genes involved ..
  64. ncbi Scale-free networks provide a unifying framework for the emergence of cooperation
    F C Santos
    GADGET, Apartado 1329, 1009 001 Lisbon, Portugal
    Phys Rev Lett 95:098104. 2005
    We study the evolution of cooperation in the framework of evolutionary game theory, adopting the prisoner's dilemma and snowdrift game as metaphors of cooperation between unrelated individuals...
  65. ncbi Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
    ..During evolution, this ancestral gene network was expanded through gene duplication and co-option of additional networks...
  66. pmc Worlds within worlds: evolution of the vertebrate gut microbiota
    Ruth E Ley
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nat Rev Microbiol 6:776-88. 2008
    ....
  67. pmc Origin and evolution of the mitochondrial proteome
    C G Kurland
    Department of Molecular Evolution, Evolutionary Biology Centre, University of Uppsala, Uppsala SE 752 36, Lund University, Lund SE 223 62, Sweden
    Microbiol Mol Biol Rev 64:786-820. 2000
    ..There are no indications of a specific alpha-proteobacterial origin to genes for glycolysis. In the absence of data to the contrary, it is assumed that the ancestral host cell was a heterotroph...
  68. ncbi Positive natural selection in the human lineage
    P C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Science 312:1614-20. 2006
    ....
  69. ncbi Optimality and evolutionary tuning of the expression level of a protein
    Erez Dekel
    Department of Molecular Cell Biology and Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 436:588-92. 2005
    ..We then performed serial dilution evolution experiments at different lactose concentrations...
  70. pmc Is evolution Darwinian or/and Lamarckian?
    Eugene V Koonin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Biol Direct 4:42. 2009
    ..Lamarck believed that evolution is driven primarily by non-randomly acquired, beneficial phenotypic changes, in particular, those directly ..
  71. doi The evolution of the arcuate fasciculus revealed with comparative DTI
    James K Rilling
    Department of Anthropology, Emory University, 207 Anthropology Building, 1557 Dickey Drive, Atlanta, Georgia 30322, USA
    Nat Neurosci 11:426-8. 2008
    ..This human specialization may be relevant to the evolution of language.
  72. ncbi Evolution in the social brain
    R I M Dunbar
    British Academy Centenary Research Project, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Science 317:1344-7. 2007
    The evolution of unusually large brains in some groups of animals, notably primates, has long been a puzzle...
  73. ncbi A likelihood framework for inferring the evolution of geographic range on phylogenetic trees
    Richard H Ree
    Department of Botany, Field Museum of Natural History, Chicago, Illinois 60605, USA
    Evolution 59:2299-311. 2005
    ..Here we describe a likelihood framework for inferring the evolution of geographic range on phylogenies that models lineage dispersal and local extinction in a set of discrete areas ..
  74. pmc Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease
    Andrew P Feinberg
    Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:1757-64. 2010
    ..Here, we propose a new non-Lamarckian theory for a role of epigenetics in evolution. We suggest that genetic variants that do not change the mean phenotype could change the variability of ..
  75. pmc Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution
    Holly R Ramage
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000767. 2009
    ..The expansion and maintenance of TA genes in the MTBC, coupled with the finding that a subset is transcriptionally activated by stress, suggests that TA systems are important for M. tuberculosis pathogenesis...
  76. ncbi A basal dromaeosaurid and size evolution preceding avian flight
    Alan H Turner
    Division of Paleontology, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 5192, USA
    Science 317:1378-81. 2007
    ..the clade including Avialae, Troodontidae, and Dromaeosauridae), phylogenetically earlier than where flight evolution is strongly inferred...
  77. pmc Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
    Michael M Mwangi
    Physics Department, Cornell University, Ithaca, NY 14850, USA
    Proc Natl Acad Sci U S A 104:9451-6. 2007
    ..Here, we apply the power of whole-genome sequencing to identify steps in the evolution of multidrug resistance in isogenic S...
  78. pmc Pattern pluralism and the Tree of Life hypothesis
    W Ford Doolittle
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 104:2043-9. 2007
    ..organisms based on their similarities and differences [the Tree of Life (TOL)] was a fact of nature, for which evolution, and in particular a branching process of descent with modification, was the explanation...
  79. pmc Evolution of the neocortex: a perspective from developmental biology
    Pasko Rakic
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 10:724-35. 2009
    The enlargement and species-specific elaboration of the cerebral neocortex during evolution holds the secret to the mental abilities of humans; however, the genetic origin and cellular mechanisms that generated the distinct evolutionary ..
  80. pmc Polygenic and directional regulatory evolution across pathways in Saccharomyces
    James H Bullard
    Division of Biostatistics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:5058-63. 2010
    ..Powerful molecular evolution approaches have been developed to test individual loci for signatures of selection...
  81. pmc Is genetic evolution predictable?
    David L Stern
    Department of Ecology and Evolutionary Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Science 323:746-51. 2009
    ..However, recent observations indicate that all genes are not equal in the eyes of evolution. Evolutionarily relevant mutations tend to accumulate in hotspot genes and at specific positions within genes...
  82. pmc Ancient animal microRNAs and the evolution of tissue identity
    Foteini Christodoulou
    Developmental Biology Unit, European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nature 463:1084-8. 2010
    The spectacular escalation in complexity in early bilaterian evolution correlates with a strong increase in the number of microRNAs...
  83. pmc Toward reconstructing the evolution of advanced moths and butterflies (Lepidoptera: Ditrysia): an initial molecular study
    Jerome C Regier
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
    BMC Evol Biol 9:280. 2009
    ..7 kb total), and character subsets therein, to resolve relationships among 123 species representing 27 (of 33) superfamilies and 55 (of 100) families of Ditrysia under maximum likelihood analysis...
  84. ncbi Genetic diversity and evolution of hepatitis C virus--15 years on
    Peter Simmonds
    Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Gen Virol 85:3173-88. 2004
    ..These contrasting aspects of conservatism and adaptability provide a fascinating paradigm in which to explore the complex selection pressures that underlie the evolution of HCV and other persistent viruses.
  85. pmc Evolution of stochastic switching rates in asymmetric fitness landscapes
    Marcel Salathé
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Genetics 182:1159-64. 2009
    ..Our finding that marginal changes in selection pressures can cause fundamentally different evolutionary outcomes is important in a wide range of fields concerned with microbial bet hedging...
  86. doi Cryptococcus neoformans: morphogenesis, infection, and evolution
    Xiaorong Lin
    Department of Biology, Texas A and M University, 3258 TAMU, College Station, TX 77843 3258, USA
    Infect Genet Evol 9:401-16. 2009
    ..Hopefully, a common theme for the convergent evolution of virulence-associated morphology will emerge with future studies.
  87. ncbi Quantifying social group evolution
    Gergely Palla
    Statistical and Biological Physics Research Group of the HAS, Pázmány P stny 1A, H 1117 Budapest, Hungary
    Nature 446:664-7. 2007
    ..communication patterns of individuals, the associated social and communication network is subject to constant evolution. Our knowledge of the mechanisms governing the underlying community dynamics is limited, but is essential for a ..
  88. ncbi Mitochondrial evolution
    M W Gray
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 283:1476-81. 1999
    ..endosymbiosis theory is a favored model for explaining the origin of mitochondria, a defining event in the evolution of eukaryotic cells...
  89. doi The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity
    Masatoshi Nei
    Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, 328 Mueller Laboratory, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:951-63. 2008
    ..It seems that mutation by gene duplication and inactivation has important roles in both the adaptive and non-adaptive evolution of chemosensation.
  90. pmc The evolution of transposable elements in natural populations of self-fertilizing Arabidopsis thaliana and its outcrossing relative Arabidopsis lyrata
    Steven Lockton
    Department of Ecology and Evolutionary Biology, University of California, Irvine, USA
    BMC Evol Biol 10:10. 2010
    ..majority of plant genomes, and thus understanding TE evolutionary dynamics is key to understanding plant genome evolution. Plant reproductive systems are diverse and mating type variation is one factor among many hypothesized to ..
  91. ncbi RANK-L and RANK: T cells, bone loss, and mammalian evolution
    Lars E Theill
    Inflammation Drug Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320 1789, USA
    Annu Rev Immunol 20:795-823. 2002
    ..Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis...
  92. pmc Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis
    Christoph Schoen
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:3473-8. 2008
    ..meningitidis. To gain insight into the evolution of virulence traits in this species, whole-genome sequences of three meningococcal carriage isolates were ..
  93. ncbi The complete sequence of the rice (Oryza sativa L.) mitochondrial genome: frequent DNA sequence acquisition and loss during the evolution of flowering plants
    Y Notsu
    Department of Genetic Diversity, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Mol Genet Genomics 268:434-45. 2002
    ..The results indicate frequent and independent DNA sequence flow to and from the mitochondrial genome during the evolution of flowering plants, and this may account for the range of genetic variation observed between the mitochondrial ..
  94. pmc Evolutionary dynamics of social dilemmas in structured heterogeneous populations
    F C Santos
    Institut de Recherches Interdisciplinaires et de Développements en Intelligence Artificielle, CP 194 6, Universite Libre de Bruxelles, Brussels, Belgium
    Proc Natl Acad Sci U S A 103:3490-4. 2006
    ..We study the evolution of cooperation, modeled in terms of the most popular dilemmas of cooperation...
  95. ncbi On the origin, evolution, and nature of programmed cell death: a timeline of four billion years
    J C Ameisen
    EMI U 9922 INSERM Université Paris 7, IFR 02, Hopital Bichat Claude Bernard, AP HP, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Cell Death Differ 9:367-93. 2002
    ..And a new view of the regulated cell suicide pathways emerges when one attempts to ask the question of when and how they may have become selected during evolution, at the level of ancestral single-celled organisms.
  96. doi Climate change and evolution: disentangling environmental and genetic responses
    P Gienapp
    Ecological Genetics Research Unit, Department of Biological and Environmental Sciences, PO Box 65, FI 00014 University of Helsinki, Finland
    Mol Ecol 17:167-78. 2008
    ..Hence, clear-cut evidence indicating a significant role for evolutionary adaptation to ongoing climate warming is conspicuously scarce...
  97. ncbi Expanded expression of Sonic Hedgehog in Astyanax cavefish: multiple consequences on forebrain development and evolution
    Arnaud Menuet
    CNRS UPR2197 DEPSN, Institut Fessard, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Development 134:845-55. 2007
    ..Here, we report how enhanced Shh midline signalling affects the evolution of telencephalic and diencephalic neuronal patterning in the blind cavefish Astyanax mexicanus, a teleost fish ..
  98. ncbi Evolution of prey in ecological time reduces the effect size of predators in experimental microcosms
    Casey P Terhorst
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4295, USA
    Ecology 91:629-36. 2010
    ..the effect of predators on prey population abundance while evolutionary biologists have measured prey trait evolution in response to predation...
  99. doi Causes and consequences of the evolution of reproductive proteins
    Leslie M Turner
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
    Int J Dev Biol 52:769-80. 2008
    ..In particular, we highlight the ways that integrating the different but complementary approaches of evolutionary and developmental biology will provide new insights into fertilization processes...
  100. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    ..It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution.
  101. doi Changes in Hox genes' structure and function during the evolution of the squamate body plan
    Nicolas Di-Poï
    National Research Center Frontiers in Genetics, Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneva 4, Switzerland
    Nature 464:99-103. 2010
    ....

Research Grants88

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Impact of Antibiotics and Vaccines on the in vivo Evolution of S. pneumoniae
    Garth Ehrlich; Fiscal Year: 2009
    C'! of S. pneumoniae" 1R01AI01808903953-051-OA1IAI "Impact of Antibiotics and Vaccines on the in vivo Evolution CO) "Impact of Antibiotics and Vaccines on the in vivo Evolution 3...
  4. Emotions are emergent events constrained by affective and conceptual processes.
    Lisa Barrett; Fiscal Year: 2009
    ..abstract_text> ..
  5. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  6. Biomedical Simulations Resource (BMSR)
    DAVID D ARGENIO; Fiscal Year: 2009
    ..The approach, called "chemical evolution" (see below), provides the means to breed drugs out of enormous synthetic small-molecule populations...
  7. Biomedical Simulations Resource (BMSR)
    DAVID Z D apos ARGENIO; Fiscal Year: 2010
    ..The approach, called "chemical evolution" (see below), provides the means to breed drugs out of enormous synthetic small-molecule populations...
  8. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..vocal non-learners would have profound impact towards understanding molecular mechanisms of vocal learning and evolution of language...
  9. The therapeutic potential of maspin in prostate cancer
    Shijie Sheng; Fiscal Year: 2009
    ..Maspin, a highly conserved protein throughout evolution, belongs to the serine protease inhibitor (serpin) superfamily...
  10. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 1993
    ..The general goal of this research is to understand the evolution of key molecular components of this system, particularly the molecules encoded by the major histocompatibility ..
  11. Evolution & Maintenance of Memory CD8 T Cells
    Katherine Luzuriaga; Fiscal Year: 2007
    ..the lineage relationship between effector and memory responses in humans and the factors that influence evolution of antigen-specific CD8+ T cell responses into the memory CD8+ T cell repertoire; 2) To characterize how cross-..
  12. Evolution & Maintenance of Memory CD8 T Cells
    Katherine Luzuriaga; Fiscal Year: 2006
    ..the lineage relationship between effector and memory responses in humans and the factors that influence evolution of antigen-specific CD8+ T cell responses into the memory CD8+ T cell repertoire; 2) To characterize how cross-..
  13. Evolution & Maintenance of Memory CD8 T Cells
    Katherine Luzuriaga; Fiscal Year: 2009
    ..the lineage relationship between effector and memory responses in humans and the factors that influence evolution of antigen-specific CD8+ T cell responses into the memory CD8+ T cell repertoire;2) To characterize how cross-..
  14. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Emergence of new viruses is a continuing threat to our society. Evolution of plus- stranded RNA viruses is frequently driven by RNA recombination, a process that joins noncontiguous RNA segments ..
  15. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emergence of new viruses is a continuing threat to our society. Evolution of plus- stranded RNA viruses is frequently driven by RNA recombination, a process that joins noncontiguous RNA segments ..
  16. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2009
    ..normal and cigarette smoke-exposed lung to mimics of aspects of COPD/CF disease;Project V: Mucus Dehydration and Evolution of COPD Lung Disease (R...
  17. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2006
    ..and cigarette smoke-exposed lung to mimics of aspects of COPD/CF disease; Project V: Mucus Dehydration and Evolution of COPD Lung Disease (R...
  18. SCCOR in Host Factors in Chronic Lung Disease
    Richard Boucher; Fiscal Year: 2007
    ..and cigarette smoke-exposed lung to mimics of aspects of COPD/CF disease; Project V: Mucus Dehydration and Evolution of COPD Lung Disease (R...
  19. Vaccination against mucosal HIV clade C transmission
    Ruth Ruprecht; Fiscal Year: 2009
    ..the virulence of R5 SHIVenvC's, generating a fully heterologous SHIVenvC, and by comparing the molecular evolution of HIV clade C env in infected African mother/infant pairs and in rhesus monkeys infected with SHIV's ..
  20. Vaccination against mucosal HIV clade C transmission
    Ruth Ruprecht; Fiscal Year: 2007
    ..the virulence of R5 SHIVenvC's, generating a fully heterologous SHIVenvC, and by comparing the molecular evolution of HIV clade C env in infected African mother/infant pairs and in rhesus monkeys infected with SHIV's ..
  21. Fish Rhabdovirus--Model of RNA Virus Evolution
    KEVIN OSHIMA; Fiscal Year: 2000
    ..fish rhabdoviruses as a model systems to better understand the mechanisms affecting the genetic variation and evolution of RNA viruses. Fish viruses offer a unique system to study because of the fish host...
  22. Institute for Translational Health Science (TL1)
    MARY DISIS; Fiscal Year: 2009
    ..The Research Education, Training, and Career Development Core will facilitate the development and evolution of research skills in every phase of a translational investigator's career. LA. Overall alms I.A.1...
  23. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Humanized transgenic mice reproduce the disease evolution in severe RA Rheumatoid arthritis (RA) is a common autoimmune disease in humans genetically associated with specific HLA class II alleles...
  24. Molecular pathogenesis and genetic diversification of childhood falciparum malari
    STEVE MYER TAYLOR; Fiscal Year: 2012
    ..Because malaria control measures are at risk of failure due to parasite evolution and changes in immunity, sustaining the gains made in malaria control will require a new generation of ..
  25. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..important component of genetic variation and play an integral role in phenotypic diversity, complex disease and evolution. Over 1300 CNVs with frequencies of >1% have been described in healthy individuals that exist as deletions or ..
  26. TEST OF NEUTRAL MOLECULAR EVOLUTION
    Martin Kreitman; Fiscal Year: 1999
    DESCRIPTION: This is a revised proposal to determine what evolutionary forces affect protein evolution. Four experiments are proposed; all are based on the collection of DNA sequence data from the closely related species Drosophila ..
  27. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    Thomas Glover; Fiscal Year: 2009
    ..important component of genetic variation and play an integral role in phenotypic diversity, complex disease and evolution. Over 1300 CNVs with frequencies of >1% have been described in healthy individuals that exist as deletions or ..
  28. MOLECULAR BASIS OF BORRELIA PATHOGENESIS
    Alan Barbour; Fiscal Year: 2002
    ..for comprehensively understanding the pathogenesis strategy of antigenic variation and the systems biology and evolution of an infectious disease...
  29. Defining evolutionary trajectories: Molecular adaptation to antibiotic resistance
    Adil Shamoo; Fiscal Year: 2009
    ..large populations of bacteria, carrying one of three antibiotic resistance genes, to continuous experimental evolution. By varying the conditions of selection during adaptation, antibiotic resistance mediated by changes to the ..
  30. MOLECULAR BASIS OF BORRELIA PATHOGENESIS
    Alan Barbour; Fiscal Year: 2005
    ..for comprehensively understanding the pathogenesis strategy of antigenic variation and the systems biology and evolution of an infectious disease...
  31. MOLECULAR BASIS OF BORRELIA PATHOGENESIS
    Alan Barbour; Fiscal Year: 2004
    ..for comprehensively understanding the pathogenesis strategy of antigenic variation and the systems biology and evolution of an infectious disease...
  32. MOLECULAR BASIS OF BORRELIA PATHOGENESIS
    Alan Barbour; Fiscal Year: 2003
    ..for comprehensively understanding the pathogenesis strategy of antigenic variation and the systems biology and evolution of an infectious disease...
  33. MOLECULAR BASIS OF BORRELIA PATHOGENESIS
    Alan Barbour; Fiscal Year: 2001
    ..for comprehensively understanding the pathogenesis strategy of antigenic variation and the systems biology and evolution of an infectious disease...
  34. Evolution of sodium channel genes
    Harold Zakon; Fiscal Year: 2009
    ..same protein from a number of different organisms to find out which amino acids do NOT change over the course of evolution. Another lesser-used strategy that we employ here is to include sequences from organisms in which that molecule ..
  35. Evolution of sodium channel genes
    Harold Zakon; Fiscal Year: 2009
    ..same protein from a number of different organisms to find out which amino acids do NOT change over the course of evolution. Another lesser-used strategy that we employ here is to include sequences from organisms in which that molecule ..
  36. Evolution of sodium channel genes
    Harold H Zakon; Fiscal Year: 2010
    ..same protein from a number of different organisms to find out which amino acids do NOT change over the course of evolution. Another lesser-used strategy that we employ here is to include sequences from organisms in which that molecule ..
  37. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2010
    ..Thus, the structure, function, and evolution of the mating-type locus (MAT) and its links to sexual development, virulence, and ecology are of considerable ..
  38. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2009
    ..Thus, the structure, function, and evolution of the mating-type locus (MAT) and its links to sexual development, virulence, and ecology are of considerable ..
  39. MOLECULAR SYSTEMATICS AND EVOLUTION OF GENUS CAULERPA
    FREDERICK ZECHMAN; Fiscal Year: 2000
    ..for comparison with the current taxonomy of the genus, and characterization of morphological and biochemical evolution, 3) compare the pattern and rate of molecular evolution for different species, and 4) determine whether the ..
  40. Evolution & Maintenance of Memory CD8 T Cells
    KATHERINE F LUZURIAGA; Fiscal Year: 2010
    ..the lineage relationship between effector and memory responses in humans and the factors that influence evolution of antigen-specific CD8+ T cell responses into the memory CD8+ T cell repertoire;2) To characterize how cross-..
  41. Diversity and evolution of Pseudomonas syringae type III effectors (RO1GM066025)
    JEFFERY DANGL; Fiscal Year: 2009
    ..This genus of pathogenic bacteria provides an excellent set of genomic and genetic tools to analyze co-evolution of host and pathogen, from the level of genome organization and horizontal gene flow down to the level of the ..
  42. Diversity and evolution of Pseudomonas syringae type III effectors (RO1GM066025)
    Jeffery L Dangl; Fiscal Year: 2010
    ..This genus of pathogenic bacteria provides an excellent set of genomic and genetic tools to analyze co-evolution of host and pathogen, from the level of genome organization and horizontal gene flow down to the level of the ..
  43. Modeling Neoplastic Progression in Barrett's Esophagus
    Carlo Maley; Fiscal Year: 2009
    ..Neoplasms progress to malignancy through a process of clonal evolution. However, the dynamics of that evolution are poorly understood...
  44. Modeling Neoplastic Progression in Barrett's Esophagus
    John W Pepper; Fiscal Year: 2010
    ..Neoplasms progress to malignancy through a process of clonal evolution. However, the dynamics of that evolution are poorly understood...
  45. EVOLUTIONARY GENETICS OF INSERTION SEQUENCES
    Daniel Hartl; Fiscal Year: 1992
    ..has been to develop E coli and related species for use as experimental organisms in population genetics and evolution. Theoretical models for the distribution and abundance of transposable insertion sequences (IS) in natural ..
  46. Convergent Molecular Evolution of Moth and Spider Silks
    NADIA AYOUB; Fiscal Year: 2007
    ..the molecular basis for adaptation is to examine the genetic architecture underlying cases of convergent evolution, the independent evolution of similar phenotypes in distantly related organisms...
  47. Convergent Molecular Evolution of Moth and Spider Silks
    NADIA AYOUB; Fiscal Year: 2009
    ..the molecular basis for adaptation is to examine the genetic architecture underlying cases of convergent evolution, the independent evolution of similar phenotypes in distantly related organisms...
  48. Modeling Neoplastic Progression in Barrett's Esophagus
    Carlo C Maley; Fiscal Year: 2011
    ..Neoplasms progress to malignancy through a process of clonal evolution. However, the dynamics of that evolution are poorly understood...
  49. Alcohol Metabolism,Primate Evolution and Paleogenetics. An Inclusive Paradigm
    Steven A Benner; Fiscal Year: 2010
    ..provide the first example where historical biology is applied to an area of interest to these institutes: the evolution of the response of primates to environmental ethanol...
  50. Alcohol Metabolism,Primate Evolution and Paleogenetics. An Inclusive Paradigm
    Steven Benner; Fiscal Year: 2009
    ..provide the first example where historical biology is applied to an area of interest to these institutes: the evolution of the response of primates to environmental ethanol...
  51. Combination immunotherapy with gene modified CD4 and CD8 T cells and stem cells
    Carl June; Fiscal Year: 2009
    ..HIV-1 specific TCRs, affinity enhance them for improved function, and test specificity and efficacy, and viral evolution/escape (Core C) in vitro and in vivo in the NOG mouse model (Core B)...
  52. Combination immunotherapy with gene modified CD4 and CD8 T cells and stem cells
    Carl H June; Fiscal Year: 2010
    ..HIV-1 specific TCRs, affinity enhance them for improved function, and test specificity and efficacy, and viral evolution/escape (Core C) in vitro and in vivo in the NOG mouse model (Core B)...
  53. Antibiotic Potentiators Targeting SOS Induction
    Timothy Opperman; Fiscal Year: 2009
    ..Induction of the SOS response increases the evolution of antibiotic resistance and the horizontal transfer of virulence factors...
  54. Evolution of the Bordetellae from Commensals to Pathogens
    Eric T Harvill; Fiscal Year: 2010
    ..The historical view of the apparent convergent evolution towards the ability to infect humans is unable to explain this...
  55. Evolution of the Bordetellae from Commensals to Pathogens
    Eric Harvill; Fiscal Year: 2009
    ..The historical view of the apparent convergent evolution towards the ability to infect humans is unable to explain this...
  56. Evolution of the Bordetellae from Commensals to Pathogens
    Eric Harvill; Fiscal Year: 2009
    ..The historical view of the apparent convergent evolution towards the ability to infect humans is unable to explain this...
  57. Host and Pathogen Evolution in Lassa Fever
    Pardis Sabeti; Fiscal Year: 2010
    ..by the applicant) Abstract: Disease-causing pathogens are among the most intriguing forces shaping human evolution, as they have a tremendous impact on our genome and themselves evolve over time...
  58. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This proposal is focused on integrating comparative genetics and molecular evolution with functional neurobiology as a means of generating a better understanding of human neuropsychiatric and ..
  59. The Evolution of Malerial Antifiolate Resistance
    Daniel Hartl; Fiscal Year: 2007
    ..Although antifolates are affordable and still clinically effective, their use has been compromised by the evolution of drug resistance...
  60. The Evolution of Malerial Antifiolate Resistance
    Daniel Hartl; Fiscal Year: 2009
    ..Although antifolates are affordable and still clinically effective, their use has been compromised by the evolution of drug resistance...
  61. HIV evolution and CD16+ monocytes as cellular reservoirs: insights into HIV/pulmo
    Sharilyn Almodovar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The dynamics of viral replication and evolution in the lungs of patients infected with Human Immunodeficiency Virus type-1 (HIV-1) remain poorly understood...
  62. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 2000
    ..goal of the proposed research is the analysis of biological sequence data to address the molecular mechanisms of evolution and the origin(s) of all viruses and related genetic elements...
  63. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..goal of the proposed research is the analysis of biological sequence data to address the molecular mechanisms of evolution and the origin(s) of all viruses and related genetic elements...
  64. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..goal of the proposed research is the analysis of biological sequence data to address the molecular mechanisms of evolution and the origin(s) of all viruses and related genetic elements...
  65. COMPUTER BASED SEQUENCE ANALYSIS AND RNA VIRUS EVOLUTION
    MARCELLA MCCLURE; Fiscal Year: 1999
    ..goal of the proposed research is the analysis of biological sequence data to address the molecular mechanisms of evolution and the origin(s) of all viruses and related genetic elements...
  66. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2000
    ..The evolution of molecular and biological behavior is set in a historical context by correlating it with the evolution of ..
  67. Sigma virus in Drosophila: a model system for the evolution of virulence
    Marta Wayne; Fiscal Year: 2009
    ..husbandry, extensive natural history, and wealth of genomic tools, is a superb model system for exploring 1) the evolution of virulence in general and 2) contrasting uniparentally vs. biparentally transmitted viruses in particular...
  68. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 2001
    ..The evolution of molecular and biological behavior is set in a historical context by correlating it with the evolution of ..
  69. EVOLUTION OF THE RIBONUCLEASE SUPERFAMILY
    Steven Benner; Fiscal Year: 1999
    ..The evolution of molecular and biological behavior is set in a historical context by correlating it with the evolution of ..
  70. Sigma virus in Drosophila: a model system for the evolution of virulence
    Marta Wayne; Fiscal Year: 2009
    ..husbandry, extensive natural history, and wealth of genomic tools, is a superb model system for exploring 1) the evolution of virulence in general and 2) contrasting uniparentally vs. biparentally transmitted viruses in particular...
  71. Isolation of ribonucleic acids that are attached to the neuronal membrane
    Terunaga Nakagawa; Fiscal Year: 2012
    ..During evolution, before DNA and proteins were part of life there was a world full of RNAs that possess self-replicating ..
  72. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2005
    How new morphologies evolve is a fundamental question in biology. Most morphological evolution involves changes in the size of organs, which is basically achieved in two ways, by changes in cell size and cell number...
  73. Isolation of ribonucleic acids that are attached to the neuronal membrane
    Terunaga Nakagawa; Fiscal Year: 2010
    ..During evolution, before DNA and proteins were part of life there was a world full of RNAs that possess self-replicating ..
  74. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2006
    How new morphologies evolve is a fundamental question in biology. Most morphological evolution involves changes in the size of organs, which is basically achieved in two ways, by changes in cell size and cell number...
  75. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2007
    How new morphologies evolve is a fundamental question in biology. Most morphological evolution involves changes in the size of organs, which is basically achieved in two ways, by changes in cell size and cell number...
  76. Origin and Evolution of Y chromosomes
    Antonio Carvalho; Fiscal Year: 2007
    ..Y chromosomes are widespread, and evolved independently in many taxa (Bull 1983). Hence their origin and evolution is a major biological question...
  77. Telomerase RNP function and evolution in Arabidopsis
    Mark A Beilstein; Fiscal Year: 2010
    ..Thus, duplication of TER and POT1 appears to have resulted in the evolution of a novel mode of telomerase regulation...
  78. Origin and Evolution of Y chromosomes
    Antonio Carvalho; Fiscal Year: 2006
    ..Y chromosomes are widespread, and evolved independently in many taxa (Bull 1983). Hence their origin and evolution is a major biological question...
  79. Evolution of Plasmodium vivax and Asian Macaque Malarias
    ANANIAS ALBERTO ESCALANTE; Fiscal Year: 2010
    ..Overall, the proposed investigation aims to understand the role of positive selection in the evolution of proteins expressed during erythrocyte invasion in P. vivax and related species...
  80. The Role of HIV-1 Evolution in Neuroadaptation
    TERESA EVERING; Fiscal Year: 2010
    ..We hypothesize that CNS-specific patterns of evolution observed through longitudinal characterization of HIV-1 envelope (env) and polymerase (pol) reflect attempts by ..
  81. Evolution of Plasmodium vivax and Asian Macaque Malarias
    Ananias Escalante; Fiscal Year: 2009
    ..Overall, the proposed investigation aims to understand the role of positive selection in the evolution of proteins expressed during erythrocyte invasion in P. vivax and related species...
  82. Comparative Analysis of the High Osmolarity Glycerol (HOG) gene regulatory networ
    JAY HARRIS KONIECZKA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Divergence in gene regulatory networks plays a major role in the evolution of every kingdom of life...
  83. STRUCTURE & EVOLUTION OF PLANT PHOTORECEPTOR PHYTOCHROME
    JOHN LAGARIAS; Fiscal Year: 2000
    ..with more than 25 full-length phytochromes have considerably extended models of the structure, function and evolution of this important plant photoreceptor...
  84. MOLECULAR EVOLUTIONARY CONSEQUENCES OF ENDOSYMBIOSIS
    Jennifer Wernegreen; Fiscal Year: 2001
    ..These shared features suggest that bacterial lifestyle severely affects patterns of molecular evolution. However, few comparative studies have addressed the processes that drive sequence and genome evolution in ..
  85. Directed Evolution of Adeno-Associated Virus Vectors for Seizure Gene Therapy
    Thomas McCown; Fiscal Year: 2007
    ..Recent developments in AAV directed evolution provide a potential means to circumvent neurosurgical intervention. Maheshri et al...
  86. Evolution of vertebrate sensory genes
    Jianzhi Zhang; Fiscal Year: 2010
    ..objective of my laboratory is to understand how genetic changes contribute to the survival, adaptation, and evolution of organisms. All organisms live in biotic and abiotic environments that change over time...