dna repair

Summary

Summary: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Top Publications

  1. pmc The DNA damage response: making it safe to play with knives
    Alberto Ciccia
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:179-204. 2010
  2. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
  3. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  4. pmc The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    Michael R Lieber
    Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Annu Rev Biochem 79:181-211. 2010
  5. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
  6. ncbi Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    Hannah Farmer
    Cancer Research UK Gene Function and Regulation Group, London, UK
    Nature 434:917-21. 2005
  7. ncbi Genome maintenance mechanisms for preventing cancer
    J H Hoeijmakers
    MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University, PO Box 1738, 3000DR Rotterdam, The Netherlands
    Nature 411:366-74. 2001
  8. ncbi Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    Helen E Bryant
    The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Nature 434:913-7. 2005
  9. pmc Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
    Sophie E Polo
    The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB21QN, United Kingdom
    Genes Dev 25:409-33. 2011
  10. pmc 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    Samuel F Bunting
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 141:243-54. 2010

Detail Information

Publications266 found, 100 shown here

  1. pmc The DNA damage response: making it safe to play with knives
    Alberto Ciccia
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:179-204. 2010
    ..This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.
  2. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
    ..Our improving understanding of DNA-damage responses is providing new avenues for disease management...
  3. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  4. pmc The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    Michael R Lieber
    Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Annu Rev Biochem 79:181-211. 2010
    ..Therefore, patients lacking normal NHEJ are not only sensitive to ionizing radiation (IR), but also severely immunodeficient...
  5. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
    ..These markers include nuclear foci of phosphorylated histone H2AX and their co-localization with DNA repair and DNA damage checkpoint factors such as 53BP1, MDC1 and NBS1...
  6. ncbi Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    Hannah Farmer
    Cancer Research UK Gene Function and Regulation Group, London, UK
    Nature 434:917-21. 2005
    ..These results illustrate how different pathways cooperate to repair damage, and suggest that the targeted inhibition of particular DNA repair pathways may allow the design of specific and less toxic therapies for cancer.
  7. ncbi Genome maintenance mechanisms for preventing cancer
    J H Hoeijmakers
    MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University, PO Box 1738, 3000DR Rotterdam, The Netherlands
    Nature 411:366-74. 2001
    ..This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis...
  8. ncbi Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    Helen E Bryant
    The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Nature 434:913-7. 2005
    Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the site of damage. Nevertheless, PARP1-/- mice are viable, fertile and do not develop early onset tumours...
  9. pmc Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
    Sophie E Polo
    The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB21QN, United Kingdom
    Genes Dev 25:409-33. 2011
    ..We review these regulatory mechanisms and discuss their biological significance to the DDR...
  10. pmc 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
    Samuel F Bunting
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 141:243-54. 2010
    Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations...
  11. ncbi Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    Lee Zou
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1542-8. 2003
    ..Our data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling...
  12. ncbi Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
    ..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
  13. pmc Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    Mary Ellen Moynahan
    Developmental Biology Program, New York, New York 10065, USA
    Nat Rev Mol Cell Biol 11:196-207. 2010
    ..Recent advances have provided a clearer understanding of the connections between these proteins and of the key steps of homologous recombination and DNA strand exchange...
  14. doi More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    Jiri Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:1161-9. 2011
    ..Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity...
  15. doi SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    Chantal Stoepker
    Department of Clinical Genetics, Vrije Universiteit VU Medical Center, Amsterdam, The Netherlands
    Nat Genet 43:138-41. 2011
    ..SLX4, which coordinates three separate endonucleases, was recently recognized as an important regulator of DNA repair. Here we report the first human individuals found to have biallelic mutations in SLX4...
  16. ncbi Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
    Barbara van Loon
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    DNA Repair (Amst) 9:604-16. 2010
    ..Here we review the importance of accurate BER of 8-oxo-G damage and its regulation in prevention of cancer...
  17. ncbi Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    Raul Mostoslavsky
    Howard Hughes Medical Institute, The Children s Hospital, CBR Institute for Biomedical Research, Harvard University Medical School, Boston, MA 02115, USA
    Cell 124:315-29. 2006
    ..We conclude that one function of SIRT6 is to promote normal DNA repair, and that SIRT6 loss leads to abnormalities in mice that overlap with aging-associated degenerative processes.
  18. ncbi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    ..These data suggest that the importance of ATM signaling for DSB repair increases as the heterochromatic component of a genome expands...
  19. doi ATM activation by oxidative stress
    Zhi Guo
    Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, and Institute for Cellular and Molecular Biology ICMB, University of Texas at Austin, Austin, TX 78712, USA
    Science 330:517-21. 2010
    ..mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates signaling cascades that initiate the DNA damage response...
  20. ncbi Poly(ADP-ribose): novel functions for an old molecule
    Valerie Schreiber
    Département Intégrité du Génome de l UMR 7175, Centre National de la Recherche Scientifique, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard S Brant, BP 10413, F 67412 Illkirch cedex, France
    Nat Rev Mol Cell Biol 7:517-28. 2006
    ..These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism...
  21. doi Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Nat Rev Mol Cell Biol 9:759-69. 2008
    ....
  22. doi Principles of ubiquitin and SUMO modifications in DNA repair
    Steven Bergink
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 458:461-7. 2009
    ....
  23. doi Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
    Emil Mladenov
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Hufelandstr 55, 45122 Essen, Germany
    Mutat Res 711:61-72. 2011
    ..We place particular emphasis on backup pathways of NHEJ and summarize their increasing significance in various cellular processes, as well as their potential contribution to carcinogenesis...
  24. doi Maintaining genome stability at the replication fork
    Dana Branzei
    Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Nat Rev Mol Cell Biol 11:208-19. 2010
    ..These mechanisms ensure that the local DNA damage response, which enables replication fork progression and DNA repair in S phase, is coupled with cell cycle transitions...
  25. doi Transcription-coupled DNA repair: two decades of progress and surprises
    Philip C Hanawalt
    Department of Biology, Stanford University, 371 Serra Mall, Stanford, California 94305 5020, USA
    Nat Rev Mol Cell Biol 9:958-70. 2008
    ..Futile cycles of TCR at naturally occurring non-canonical DNA structures might contribute to genomic instability and genetic disease...
  26. pmc DNA interstrand crosslink repair and cancer
    Andrew J Deans
    London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms EN63LD, UK
    Nat Rev Cancer 11:467-80. 2011
    ..Understanding how the FA pathway links nucleases, helicases and other DNA-processing enzymes should lead to more targeted uses of ICL-inducing agents in cancer treatment and could provide novel insights into drug resistance...
  27. doi MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    Mitch McVey
    Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
    Trends Genet 24:529-38. 2008
    ..We propose a mechanistic model for MMEJ and highlight important questions for future research...
  28. ncbi Cisplatin: mode of cytotoxic action and molecular basis of resistance
    Zahid H Siddik
    Department of Experimental Therapeutics, Unit 104, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Oncogene 22:7265-79. 2003
    ..The molecular signature defining the resistant phenotype varies between tumors, and the number of resistance mechanisms activated in response to selection pressures dictates the overall extent of cisplatin resistance...
  29. pmc Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells
    Teresa Neumaier
    Institute of Radiation Protection, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 109:443-8. 2012
    ....
  30. pmc DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
    Burkhard Jakob
    Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Planckstrasse 1, 64291 Darmstadt, Germany
    Nucleic Acids Res 39:6489-99. 2011
    ..Finally, we describe a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces...
  31. ncbi Regulation of DNA double-strand break repair pathway choice
    Meena Shrivastav
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, USA
    Cell Res 18:134-47. 2008
    ....
  32. ncbi Expandable DNA repeats and human disease
    Sergei M Mirkin
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Nature 447:932-40. 2007
    ..It is becoming clear that the peculiar structures of repeat-containing transcripts are at the heart of the pathogenesis of these diseases...
  33. pmc Targeting DNA topoisomerase II in cancer chemotherapy
    John L Nitiss
    Molecular Pharmacology Department, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Nat Rev Cancer 9:338-50. 2009
    ..These studies promise refined targeting of TOP2 as an effective anticancer strategy...
  34. pmc XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999
    ..These results establish that XRCC3-mediated homologous recombination can reverse DNA damage that would otherwise be mutagenic or lethal...
  35. pmc Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
    Anand G Patel
    Department of Molecular Pharmacology and Experimental Therapeutics, Radiation Oncology, and Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 108:3406-11. 2011
    ....
  36. pmc BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    Amitabh V Nimonkar
    Department of Microbiology, University of California at Davis, Davis, California 95616, USA
    Genes Dev 25:350-62. 2011
    ..BLM increases the affinity of EXO1 for ends, and MRN recruits and enhances the processivity of EXO1. Our results establish two of the core machineries that initiate recombinational DNA repair in human cells.
  37. doi Assembly and function of DNA double-strand break repair foci in mammalian cells
    Simon Bekker-Jensen
    Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen N, Denmark
    DNA Repair (Amst) 9:1219-28. 2010
    ..Despite such advances, however, our understanding of the biological relevance of such DNA repair foci still remains limited...
  38. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity...
  39. doi Repeat instability as the basis for human diseases and as a potential target for therapy
    Arturo López Castel
    Program of Genetics and Genome Biology, The Hospital for Sick Children, 101 College Avenue, East Tower 15 312, TMDT Toronto, Ontario, Canada, M5G 1L7
    Nat Rev Mol Cell Biol 11:165-70. 2010
    ....
  40. doi Mutation of the RAD51C gene in a Fanconi anemia-like disorder
    Fiona Vaz
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Nat Genet 42:406-9. 2010
    ..RAD51C is a member of the RAD51-like gene family involved in homologous recombination-mediated DNA repair. The mutation results in loss of RAD51 focus formation in response to DNA damage and in increased cellular ..
  41. pmc 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    Peter Bouwman
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Struct Mol Biol 17:688-95. 2010
    ..BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced ..
  42. doi Cyclical DNA methylation of a transcriptionally active promoter
    Raphaël Métivier
    Universite de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu, 35042 Rennes Cedex, France
    Nature 452:45-50. 2008
    ..Cyclical changes in the methylation status of promoter CpGs may thus represent a critical event in transcriptional achievement...
  43. ncbi Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
    Marzena Bienko
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Science 310:1821-4. 2005
    ..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
  44. ncbi gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
    Markus Lobrich
    Darmstadt University of Technology, Radiation Biology and DNA Repair, Darmstadt, Germany
    Cell Cycle 9:662-9. 2010
    ..We discuss the limitations and benefits of the technique, enabling the procedure to be optimally exploited but not misused...
  45. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...
  46. pmc Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
    Kyle M Miller
    The Gurdon Institute, University of Cambridge, Cambridge, UK
    Nat Struct Mol Biol 17:1144-51. 2010
    ....
  47. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
    ....
  48. pmc Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    Andrea Kinner
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
    Nucleic Acids Res 36:5678-94. 2008
    ..We conclude with a critical analysis of the strengths and weaknesses of the approach and present some interesting applications of the resulting methodology...
  49. pmc A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
    Danny M Chou
    Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:18475-80. 2010
    ..and mass spectrometry to uncover proteins that associate with damaged DNA, many of which are involved in DNA repair or nucleolar function...
  50. pmc ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    Claudia Cosentino
    Genome Stability Unit, Clare Laboratories, London Research Institute, Cancer Research UK, South Mimms, UK
    EMBO J 30:546-55. 2011
    ..These data suggest that ATM protects cells from ROS accumulation by stimulating NADPH production and promoting the synthesis of nucleotides required for the repair of DSBs...
  51. pmc MicroRNA regulation of DNA repair gene expression in hypoxic stress
    Meredith E Crosby
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Cancer Res 69:1221-9. 2009
    ..Bioinformatics analyses suggested that these miRs could regulate factors implicated in DNA repair pathways...
  52. doi SIRT6 promotes DNA repair under stress by activating PARP1
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 332:1443-6. 2011
    ....
  53. doi DNA repair in mammalian cells : Nucleotide excision repair: variations on versatility
    T Nouspikel
    Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom
    Cell Mol Life Sci 66:994-1009. 2009
    Nucleotide excision repair (NER) is one of the most versatile DNA repair systems...
  54. pmc Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes
    Ovidiu Popa
    Institute of Botany III, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Genome Res 21:599-609. 2011
    ..revealed that recipient genomes of distant transfers encode proteins of nonhomologous end-joining (NHEJ; a DNA repair mechanism) far more frequently than the recipient lacking that mechanism...
  55. pmc Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
    Craig MacKay
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Cell 142:65-76. 2010
    ..Depletion of FAN1 from human cells causes hypersensitivity to ICLs, defects in ICL repair, and genome instability. These data at least partly explain how ubiquitination of FANCD2 promotes DNA repair.
  56. ncbi DNA double-strand break repair: from mechanistic understanding to cancer treatment
    Thomas Helleday
    Radiation Oncology and Biology, University of Oxford, Oxford OX3 7LJ, UK
    DNA Repair (Amst) 6:923-35. 2007
    ....
  57. ncbi Cellular processing of platinum anticancer drugs
    Dong Wang
    Department of Chemistry, Massachusetts Institute of Technology, Room 18 498, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 4:307-20. 2005
    ..those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death...
  58. ncbi DNA repair pathways as targets for cancer therapy
    Thomas Helleday
    Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Nat Rev Cancer 8:193-204. 2008
    b>DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging ..
  59. pmc Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    Brandi L Mahaney
    Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Biochem J 417:639-50. 2009
    ..In the present review, we will discuss our current understanding of the mechanism of NHEJ in mammalian cells and discuss the roles of DNA-PKcs and DNA-PK-mediated phosphorylation in NHEJ...
  60. doi DNA damage response and transcription
    Saskia Lagerwerf
    Department of Toxicogenetics, Leiden University Medical Center, 2333 RC Leiden, The Netherlands
    DNA Repair (Amst) 10:743-50. 2011
    ....
  61. pmc Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11
    Katharina Schlacher
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 145:529-42. 2011
    ..Thus, BRCA2 prevents rather than repairs nucleolytic lesions at stalled replication forks to maintain genomic integrity and hence likely suppresses tumorigenesis through this replication-specific function...
  62. pmc Balancing repair and tolerance of DNA damage caused by alkylating agents
    Dragony Fu
    Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Cancer 12:104-20. 2012
    ..Furthermore, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylating agent toxicity...
  63. pmc Human SIRT6 promotes DNA end resection through CtIP deacetylation
    Abderrahmane Kaidi
    Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 329:1348-53. 2010
    ..These findings further clarify how SIRT6 promotes genome stability...
  64. doi The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, United Kingdom
    DNA Repair (Amst) 9:1273-82. 2010
    ..Collectively, these recent studies highlight not only how chromatin complexity influences the factors required for DSB repair but also the pathway choice...
  65. doi A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
    Cecilia Cotta-Ramusino
    Department of Genetics, Harvard University Medical School, Howard Hughes Medical Institute, Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 332:1313-7. 2011
    The DNA damage response (DDR) is brought about by a protein kinase cascade that orchestrates DNA repair through transcriptional and posttranslational mechanisms. Cell cycle arrest is a hallmark of the DDR...
  66. ncbi Oxidative DNA damage: mechanisms, mutation, and disease
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    FASEB J 17:1195-214. 2003
    ....
  67. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
    ..complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man...
  68. pmc Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    Pablo Huertas
    Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    J Biol Chem 284:9558-65. 2009
    ..These results suggest that CDK-mediated control of resection in human cells operates by mechanisms similar to those recently established in yeast...
  69. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Surprisingly, four nucleotide excision repair genes were induced, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation...
  70. pmc Purified human BRCA2 stimulates RAD51-mediated recombination
    Ryan B Jensen
    Department of Microbiology, University of California, Davis, California 95616, USA
    Nature 467:678-83. 2010
    ..report the purification of full-length BRCA2 and show that it both binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA)...
  71. ncbi Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
    Angelo Lombardo
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina, 58, 20132 Milan, Italy
    Nat Biotechnol 25:1298-306. 2007
    ....
  72. pmc Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
    Jie Liu
    Department of Microbiology, University of California Davis, Davis, CA, USA
    Nat Struct Mol Biol 17:1260-2. 2010
    ..We report the purification of full-length human BRCA2 and show that it binds to ~6 RAD51 molecules and promotes RAD51 binding to ssDNA coated by replication protein A (RPA), in a manner that is stimulated by DSS1...
  73. pmc Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
    Samira Fekairi
    Genome Instability and Carcinogenesis UPR3081 CNRS, Conventionné par l Université d Aix Marseille 2, IGC, IMM 31 chemin Joseph Aiguier, 13402 Marseille, France
    Cell 138:78-89. 2009
    Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination...
  74. pmc How the fanconi anemia pathway guards the genome
    George Lucian Moldovan
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Annu Rev Genet 43:223-49. 2009
    ..The Fanconi Anemia pathway is thought to coordinate a complex mechanism that enlists elements of three classic DNA repair pathways, namely homologous recombination, nucleotide excision repair, and mutagenic translesion synthesis, in ..
  75. doi Increased mutagenesis and unique mutation signature associated with mitotic gene conversion
    Wade M Hicks
    Department of Biology and Rosenstiel Center, Brandeis University, Waltham, MA 02454 9110, USA
    Science 329:82-5. 2010
    ..These observations suggest that increased DSB frequencies in oncogene-activated mammalian cells may also increase the probability of acquiring mutations required for transition to a cancerous state...
  76. doi 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    Angela T Noon
    Genome Damage and Stability Centre, University of Sussex, East Sussex, BN1 9RQ, UK
    Nat Cell Biol 12:177-84. 2010
    ..We propose that ionizing-radiation induced foci (IRIF) spatially concentrate ATM activity to promote localized alterations in regions of chromatin otherwise inhibitory to repair...
  77. pmc The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage
    Godelieve Smeenk
    Department of Toxicogenetics, Leiden University Medical Center, Leiden 2300RC, Netherlands
    J Cell Biol 190:741-9. 2010
    ..IR)-induced DNA double-strand breaks (DSBs) by orchestrating events that coordinate cell cycle progression and DNA repair. How cells signal and repair DSBs is not yet fully understood...
  78. pmc p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
    H Christian Reinhardt
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Cancer Cell 11:175-89. 2007
    ..response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the cell cycle and initiate DNA repair. We show that, in the absence of p53, cells depend on a third cell-cycle checkpoint pathway involving p38MAPK/..
  79. doi The checkpoint response to replication stress
    Dana Branzei
    FIRC Institute of Molecular Oncology Foundation IFOM IEO campus, Via Adamello 16, 20139 Milan, Italy
    DNA Repair (Amst) 8:1038-46. 2009
    ..checkpoint is to maintain the integrity of the replication forks while facilitating replication completion and DNA repair and coordinating these events with cell cycle transitions...
  80. pmc BRCA1 and its toolbox for the maintenance of genome integrity
    Michael S Y Huen
    Department of Anatomy, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Hong Kong
    Nat Rev Mol Cell Biol 11:138-48. 2010
    ..Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response...
  81. pmc Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 23:67-79. 2009
    ..Importantly, Mph1, but not a helicase-defective variant, dissociates Rad51-made D-loops. Overall, the results from our analyses suggest a new role of Mph1 in promoting the noncrossover repair of DNA double-strand breaks...
  82. doi Identification of Holliday junction resolvases from humans and yeast
    Stephen C Y Ip
    Genetic Recombination Laboratory, Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Nature 456:357-61. 2008
    Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation...
  83. doi Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency
    Claudia Kerzendorfer
    Human DNA Damage Response Disorders Group, Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, East Sussex, BN1 9RQ, UK
    DNA Repair (Amst) 8:1139-52. 2009
    ..Finally, we will discuss how defects in the DDR result in some unexpected clinical features before describing how the nature of a DDR defect impacts on the management and treatment of individuals with these conditions...
  84. pmc Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    Jennifer M Svendsen
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 138:63-77. 2009
    ..Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312...
  85. pmc Collaboration and competition between DNA double-strand break repair pathways
    Elizabeth M Kass
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    FEBS Lett 584:3703-8. 2010
    ....
  86. pmc ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
    Andrea Beucher
    Darmstadt University of Technology, Radiation Biology and DNA Repair, Darmstadt, Germany
    EMBO J 28:3413-27. 2009
    ..We suggest that Artemis endonuclease removes lesions or secondary structures, which inhibit end resection and preclude the completion of HR or NHEJ...
  87. doi The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
    Joanna R Morris
    Department of Medical and Molecular Genetics, King s College London, Guy s Medical School Campus, London SE1 9RT, UK
    Nature 462:886-90. 2009
    ..These data demonstrate that the SUMOylation pathway plays a significant role in mammalian DNA damage response...
  88. pmc Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1
    Christopher Josh Ramey
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center at Fitzsimons, P O Box 6511, Aurora, CO 80045, USA
    Mol Cell Biol 24:10313-27. 2004
    ..than the failure to repair double-strand DNA breaks, because asf1 mutants are fully functional for double-strand DNA repair. Our data indicate that the altered chromatin structure in asf1 mutants leads to elevated rates of spontaneous ..
  89. pmc Roles of Werner syndrome protein in protection of genome integrity
    Marie L Rossi
    Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, MD 21224, USA
    DNA Repair (Amst) 9:331-44. 2010
    ..In this work, we will summarize some of the early studies on the cellular roles of WRN and highlight the recent findings that shed some light on the link between the protein with its cellular functions and the disease pathology...
  90. pmc Double Holliday junctions are intermediates of DNA break repair
    Malgorzata Bzymek
    Department of Microbiology, University of California Davis, Davis, California 95616, USA
    Nature 464:937-41. 2010
    ..Thus, although DHJs are identified as intermediates of DSB-promoted recombination in both mitotic and meiotic cells, their formation is distinctly regulated according to the specific dictates of the two cellular programs...
  91. pmc Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
    Jurgen A Marteijn
    Department of Genetics, Center for Biomedical Genetics, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    J Cell Biol 186:835-47. 2009
    ..Although both lesions are processed by independent repair pathways and trigger signaling responses by distinct kinases, they eventually generate the same epigenetic mark, possibly functioning in DNA damage signal amplification...
  92. ncbi Meganucleases and DNA double-strand break-induced recombination: perspectives for gene therapy
    Frédéric Pâques
    Cellectis SA, 102, route de Noisy, 93 340 Romainville Cedex France
    Curr Gene Ther 7:49-66. 2007
    ..Finally, we will discuss the main issues that will need to be addressed in order to bring this promising technology to the patient...
  93. pmc The emerging role of nuclear architecture in DNA repair and genome maintenance
    Tom Misteli
    National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 10:243-54. 2009
    b>DNA repair and maintenance of genome stability are crucial to cellular and organismal function, and defects in these processes have been implicated in cancer and ageing...
  94. ncbi The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    Claus Storgaard Sørensen
    Danish Cancer Society, Institute of Cancer Biology, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 7:195-201. 2005
    ..After hydroxyurea treatment, the essential recombination repair protein RAD51 is recruited to DNA repair foci performing a vital role in correct HRR...
  95. pmc The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
    Dorthe Helena Larsen
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    J Cell Biol 190:731-40. 2010
    In response to ionizing radiation (IR), cells delay cell cycle progression and activate DNA repair. Both processes are vital for genome integrity, but the mechanisms involved in their coordination are not fully understood...
  96. pmc ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells
    Bret R Adams
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Aging (Albany NY) 2:582-96. 2010
    ..Altogether, we conclude that NHEJ in hESCs is largely independent of ATM, DNA-PKcs, and PARP but dependent on XRCC4 with repair fidelity several-fold greater than in astrocytes...
  97. doi Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation
    Michele Giannattasio
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Milano, 20133, Italy
    Mol Cell 40:50-62. 2010
    ..Our work has significant implications for understanding the coordination between repair of DNA lesions and checkpoint pathways to preserve genome stability...
  98. ncbi DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response
    Patrice Y Ohouo
    Graduate Program in Biochemistry, Molecular and Cell Biology, Weill Institute for Cell and Molecular Biology, Cornell University, 339 Weill Hall, Ithaca, New York 14853 7202, USA
    Mol Cell 39:300-6. 2010
    ..Though it has been proposed to promote fork repair, the mechanisms by which Mec1 regulates DNA repair factors remain unclear...
  99. pmc A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
    Tracey A Dobbs
    Department of Biochemistry, Southern Alberta Cancer Research Institute, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada
    DNA Repair (Amst) 9:1307-14. 2010
    ....
  100. pmc Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    Mary Mohrin
    The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Medicine, Division of Hematology Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 7:174-85. 2010
    ..We show that quiescent and proliferating HSCs are equally radioprotected but use different types of DNA repair mechanisms...
  101. pmc Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
    Meredith A Morgan
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5637, USA
    Cancer Res 70:4972-81. 2010
    ..Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer...

Research Grants150 found, 100 shown here

  1. Structural Biochemistry of DNA Dealkylation
    John A Tainer; Fiscal Year: 2010
    ..We propose to characterize the structural cell biology of these two key facets of alkylation damage repair, which are directly relevant to improved cancer chemotherapies and risk assessments for environmental agents. ..
  2. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  3. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..machinery to replicate its ssDNA genome;rather, it appears to induce a DDR and subsequently co-opts the host DNA repair mechanism to facilitate its own replication...
  4. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..gene has multiple functions needed for the cellular response to DNA damage, including cell cycle checkpoints, DNA repair and pro-apoptotic activities. In addition, RAD9 can, like p53, act as a sequence specific transcription factor...
  5. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..My career goal is to expand my current mentored project on DNA repair, initiated three years ago, as an academic principal investigator and to develop innovative strategies to fight ..
  6. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..DDB1 regulates diverse cellular functions such as DNA replication, cell cycle, innate immunity, and damaged DNA repair. We hypothesize that HBx acts as a viral DCAF, and displaces one or more cellular DCAFs from the Cul4-DDB1 ..
  7. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..a family of 18 cell signaling enzymes, which are involved in the regulation of DNA-binding proteins and DNA repair. These enzymes catalyze the transfer of ADP-ribose units from NAD+ to a number of acceptor proteins (by a ..
  8. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..LKB1-deficient cells exhibit a delayed DDR and reduced DNA repair after exposure to ionizing radiation (IR)...
  9. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
    ..potential of other genotoxic agents such as ultraviolet radiation, at least in part, through inhibition of DNA repair processes...
  10. Metnase, PIKK, and RPA Roles in DNA Damage and Replication Stress Responses
    Jac A Nickoloff; Fiscal Year: 2013
    ..Normal and tumor cells respond to DNA damage and associated replication stress by activating DNA repair, cell cycle arrest (checkpoint) systems, and when damage is severe, programmed death pathways, collectively ..
  11. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..effect, as the pre-DNA damage co-localization properties of the V(D)J recombinase were re- established upon DNA repair. Moreover, the IR-induced redistribution of the V(D)J recombinase was blocked by addition of an inhibitor to DNA ..
  12. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..SIRT1 is the best studied. Major processes controlled by SIRT1 include DNA repair, protein folding, fatty acid and glucose metabolism, hypoxic responses, autophagy, and anti-apoptotic mechanisms...
  13. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ..test the hypothesis that hyperglycemia-induced accumulation of mutagenic DNA-AGEs in conjunction with attenuated DNA repair propels genomic instability and substantially increases cancer susceptibility...
  14. The role fo the TPP1 peotein in telomerase function and cancer cell survival
    Jayakrishnan Nandakumar; Fiscal Year: 2013
    ..protein folding, then, as a graduate student I employed biochemistry and x-ray crystallography to study RNA/DNA repair, and now, working as a post-doc with Dr...
  15. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..Furthermore, this knowledge will allow us eventually to devise strategies for modulating MPG expression for chemopreventive and therapeutic purposes. ..
  16. Checkpoints and double strand breaks in S. pombe meiosis
    Susan L Forsburg; Fiscal Year: 2013
    ..kinase Hsk1 and its subunit Dfp1 (ScCdc7, ScDbf4) which normally preserve replication fork integrity and promote DNA repair, instead actively promote double strand break formation during meiosis...
  17. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..cancer;(6) mechanisms that control genomic integrity including DNA replication checkpoints and post-replication DNA repair;(7) novel approaches including genomics, systems biology, and single molecule studies...
  18. Defining the role of proteostasis pathways in cancer drug resistance
    ERICA LYNN CAIN; Fiscal Year: 2013
    ..Both Breast Cancer 2 susceptibility protein (BRCA2) and PARP1 function in DNA repair. Loss-of-function of either gene is not lethal, however, loss of both leads to an accumulation of double-strand ..
  19. Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
    Lopa Mishra; Fiscal Year: 2013
    ..However, sensors for genotoxicity leading to aberrant DNA repair remain elusive...
  20. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..In support, people with certain DNA repair defective syndromes including Fanconi anemia (FA) and Bloom syndrome (BS) exhibit MDS...
  21. Development of Novel Agents Targeting Genome Stability and Maintenance for Treati
    John J Turchi; Fiscal Year: 2013
    ..Both intrinsically and acquired resistant EOC often display alterations in DNA repair or damage tolerance and thus inhibition of DNA repair pathways holds the potential to sensitize these cells to ..
  22. Role of Non-Core RAG1 in DSB Repair, Cell Survival, and Cell Cycle Progression
    Julie Horowitz; Fiscal Year: 2013
    ..Further, I will test the ability of non-core Rag1 regions to facilitate DNA repair via promoting H2AX phosphorylation and H2AX, H2A, and H2B ubiquitylation following RAG DSBs...
  23. Establishment of sister chromatid cohesion
    Douglas E Koshland; Fiscal Year: 2013
    ..Chromosomes are organized into morphologically distinct higher-order structures during chromosome segregation, DNA repair, and transcription...
  24. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..These DNA lesions activate a multifaceted DNA damage response (DDR) to promote DNA repair by respective single and double strand break repair pathways (SSBR and DSBR)...
  25. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    ..to ask whether compensatory biological mechanisms exist that might couple vitamin D photosynthesis to the DNA repair pathways relevant for ultraviolet radiation (UV)...
  26. Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis
    Raul Mostoslavsky; Fiscal Year: 2013
    ..Recently, we discovered that the mammalian SIRT6 is a chromatin factor that influences glucose metabolism and DNA repair. In mice, SIRT6-deficiency provokes a profound and lethal hypoglycemia which culminates in accelerated death...
  27. ROLES AND REGULATION OF P53
    Carol Prives; Fiscal Year: 2013
    ..Levine will also study the roles of SNPs in p63 or p73 that influence DNA repair systems in female eggs and copy number variation that affect cancer in offspring Scott Lowe will continue to ..
  28. Characterization of lung cancer radiosensitizers from genome-wide RNAi screens
    David Kozono; Fiscal Year: 2013
    ..D., and I sought mentorship under Dr. Alan D'Andrea to study DNA repair biology...
  29. Mitochondrial DNA Repair and Biogenesis
    Raquel R Bartz; Fiscal Year: 2013
    ..The PI will investigate the role of the mitochondrial DNA repair (mDNA) enzyme, OGG1 and nuclear coactivators, PGC-11 and its family members, in mtDNA maintenance and biogenesis ..
  30. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    ..of GBMs are not responsive due to the resistance mediated by O6-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that limits the radiosensitizing and cytotoxic effects of TMZ...
  31. Oxidative DNA base damage and repair at telomeres and the relevance to cell senes
    PATRICIA LYNN OPRESKO; Fiscal Year: 2013
    ..The results will pave the way for future work examining how telomeric damage and repair change with age and vary with cell type, and should lead to new strategies for preserving telomere function to promote healthy aging. ! ..
  32. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..Fortunately, cells can respond to DNA damage by regulating gene expression to coordinate proper DNA repair, replication, cell cycle and metabolism. Years of work in S...
  33. Cell cycle checkpoint defects lead to chronic inflammation in RA
    Thomas M Aune; Fiscal Year: 2013
    ..Activation of cell cycle checkpoints and the DNA repair machinery repairs DNA damage...
  34. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    ..rescued oocytes by whole genome sequencing of offspring and genetic analyses of potential alternative DNA repair pathways...
  35. Epigenetic control of sex chromosome behavior in meiosis.
    JoAnne Engebrecht; Fiscal Year: 2013
    ..Here we will also probe the physical interactions between chromatin, chromatin modifiers, DNA repair and checkpoint proteins...
  36. The role of Mc1r in melanocytic UV-induced DNA damage and repair responses
    JOHN A DORAZIO; Fiscal Year: 2013
    ..Together, these studies will lay the foundation for future translational studies designed to develop novel small molecule-based approaches for UV and cancer protection to prevent many cases of melanoma. ..
  37. Bacteriophage Control of DNA Repair in Streptococcus Pyogenes
    WILLIAM MICHAEL MCSHAN; Fiscal Year: 2013
    ..This research will determine the role of a bacterial virus in regulating a key DNA repair system...
  38. CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITY
    Tej K Pandita; Fiscal Year: 2013
    ..A major impediment in the mammalian DNA repair field to answering this type of question has been the non-specificity of DNA damage inducing agents (for example:..
  39. MECHANISMS RESPONSIBLE FOR GENOMIC INSTABILITY IN PREMATURE AGING LAMINOPATHIES
    SUSANA GONZALO HERVAS; Fiscal Year: 2013
    ..Loss of A-type lamins leads to telomere shortening, telomeric chromatin defects, impaired DNA repair, increased genomic instability, and defects in the non-homologous end-joining of dysfunctional telomeres, a ..
  40. In vivo detection and genome-wide location analysis of DNA-adducts
    Stephen B Howell; Fiscal Year: 2013
    ..While mechanisms underlying sensitivity, agent homeostasis, detoxification, DNA repair and apoptosis, have been well investigated, the central molecular event, the formation of adducts, is not well ..
  41. Targeting Rad6 Postreplication DNA Repair to Treat Triple Negative Breast Cancer
    Malathy P V Shekhar; Fiscal Year: 2013
    ..BRCA1-associated BrCas have aberrant DNA repair, and since TNBCs share several histologic features with BRCA1-related BrCa, DNA repair pathways are thought to ..
  42. Novel Strategy to Sensitize Prostate Cancer Cells to Radiation
    Marja T Nevalainen; Fiscal Year: 2013
    ..damage in PCa cells and 7) Stat5a/b up-regulates Rad51 which is the key protein in Homologous Recombination (HR)-DNA repair in mammalian cells...
  43. Novel approaches to enhance tumor cell cytotoxicity of alkylating agents
    Robert W Sobol; Fiscal Year: 2013
    ..Insights gained from these studies have the potential to identify novel targets for adjuvant therapies including BER inhibitors and NAD+ biosynthesis modulators that can be combined with alkylators to improve anticancer drug efficacy. ..
  44. Structural Biochemistry of PARP-1
    John Pascal; Fiscal Year: 2012
    ..Despite a growing interest in PARP-1 inhibitors and the discovery of expanded roles for PARP-1 activity in DNA repair, transcriptional regulation, and apoptotic signaling, there are few insights into the mechanism of PARP-1 ..
  45. DNA Repair Enzymes for the Prevention of Skin Cancer
    Amanda K McCullough; Fiscal Year: 2013
    ..Restoration Genetics, Inc (RGI) has developed and patented technologies activating a second, nuclear- targeted DNA repair pathway, base excision repair, for the removal of the primary DNA lesions caused by sunlight exposure, ..
  46. DNA Repair Enzymes for the Prevention of Skin Cancer
    Amanda K McCullough; Fiscal Year: 2012
    ..Restoration Genetics, Inc (RGI) has developed and patented technologies activating a second, nuclear- targeted DNA repair pathway, base excision repair, for the removal of the primary DNA lesions caused by sunlight exposure, ..
  47. DNA Repair Enzymes for the Prevention of Skin Cancer
    Amanda K McCullough; Fiscal Year: 2013
    ..Restoration Genetics, Inc (RGI) has developed and patented technologies activating a second, nuclear- targeted DNA repair pathway, base excision repair, for the removal of the primary DNA lesions caused by sunlight exposure, ..
  48. Understanding the role of PCNA in DNA mismatch repair subpathways
    EVA MARIE GOELLNER; Fiscal Year: 2013
    ..Understanding DNA repair pathways is also critical given that many chemotherapeutic agents function by damaging DNA...
  49. Na-K-Cl cotransporter in Glioblastoma Multiforme
    Dandan Sun; Fiscal Year: 2013
    ..TMZ causes a DNA O6-methylguanine lesion which triggers DNA repair, depletes the enzyme O6-methylguanine methyltransferase, and leads to apoptotic cell death...
  50. Mechanisms of SIRT2 Function in the Replication Stress Response
    David Yu; Fiscal Year: 2013
    ..RSR) recognizes challenges to DNA replication from insults such as ionizing radiation and coordinates diverse DNA repair and cell cycle checkpoint pathways necessary to maintain genome integrity...
  51. A novel role for PARP1 in regulation of autophagy
    Gen Sheng Wu; Fiscal Year: 2013
    ..provided by applicant): An extensive literature documents the role of poly(ADP-ribose)polymerase 1 (PARP1) in DNA repair. PARP1 recognizes and is activated by single strand DNA breaks...
  52. Studying the role of the nuclear lamina in age dependent demyelination
    Quasar S Padiath; Fiscal Year: 2013
    ..integrity of the nucleus and has roles in essential cellular processes including transcription, DNA replication, DNA repair, and epigenetic regulation...
  53. The Meningioma Consortium: Genome-Wide Association Study
    Elizabeth B Claus; Fiscal Year: 2013
    ..gene) and 4) Replicate previous associations from the Tineas Capitas study of meningioma risk with variants in DNA repair genes (KRAS2, ERCC2, CCND1)...
  54. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David A Boothman; Fiscal Year: 2013
    ..Tumor-specificity to DNA repair inhibitors will resul in dramatic NAD+/ATP losses and inhibition of glucose metabolism and DNA repair...
  55. Cellular Responses to DNA Replication Stress
    Marcus Smolka; Fiscal Year: 2013
    ..replication factor Dpb11 (ortholog of human TopBP1) with Slx4, a scaffold protein that coordinates the action of DNA repair factors...
  56. Analysis of the Mammalian DNA Damage Response
    Stephen J Elledge; Fiscal Year: 2013
    ..In addition, it directly orchestrates DNA repair choices because senses different DNA damage structures and transduces that information in cis to activate ..
  57. Targeting nucleotide excision repair in combination cancer therapy
    John J Turchi; Fiscal Year: 2013
    ..Our previous data identified two classes of RPA inhibitors, both of which decrease ..
  58. Exploring the Association Between Immune-Related Genetic Variation and HNSCC
    Chaya Levovitz; Fiscal Year: 2013
    ..examine only several single nucleotide polymorphisms (SNPs) and focus on variants in carcinogen metabolism and DNA repair genes12-15...
  59. Lig4R278H contribution to HSC and IgH class switching defects and malignancies
    Catherine T Yan; Fiscal Year: 2013
    ..In mice, a deficiency in Lig4 is embryonic lethal, and in humans, mutations in Lig4 underlie the rare genetic DNA repair disorder, DNA Lig4 Syndrome...
  60. Histone Tail Interactions and Functions in Chromatin
    Jeffrey J Hayes; Fiscal Year: 2013
    ..These results will provide a basis for understanding how transcription, replication, DNA repair, and other processes occur in a chromatin environment.
  61. LUNG IMMUNOPATHOLOGY TRAINING
    Nicholas W Lukacs; Fiscal Year: 2013
    ..The research areas of focus include lung inflammation (mediators and regulators), complement, apoptosis, DNA repair, epigenetics, immunopathology (including the roles of oxidants, proteases, cytokines, and chemokines), and cell ..
  62. Histone methylation controls activation of ATM and the radiation response
    Brendan D Price; Fiscal Year: 2013
    ..DSB repair requires the loading of DNA repair proteins, including the ATM kinase, onto the chromatin at the site of damage...
  63. GENETIC TOXICITY IN BACTERIA AND RODENTS
    LES RECIO; Fiscal Year: 2013
    ..In addition, in vitro Comet assays have been conducted to compare DNA repair activities among several different cell lines in an effort to better understand the role of certain mutant genes ..
  64. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..There are extensive DNA repair systems that can correct DNA damage caused by ROS and MPO-related carcinogen activation before cell replication ..
  65. Evaluating the role of histone H3K79 methylation states in DNA damage repair in S
    Jeffrey S Thompson; Fiscal Year: 2010
    ..Dysfunction of these systems is the root cause of a variety of DNA damage sensitivity disorders in humans. DNA repair in eukaryotic organisms is influenced by a family of highly conserved proteins called histones, which serve to ..
  66. Genetic Instability & Risk for Esophageal Carcinoma
    Xifeng Wu; Fiscal Year: 2009
    ..1.4. Estimate the frequencies of SNPs in DNA repair genes implicated in the NER, BER, and the DSB pathways...
  67. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2009
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  68. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  69. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2009
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  70. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2010
    ..The goal of this project is to understand the mechanisms of regulation of BER pathway and devise strategies for modulating the expression of BER genes to improve the efficacy of chemopreventives and therapeutics. ..
  71. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2011
    ..The goal of this project is to understand the mechanisms of regulation of BER pathway and devise strategies for modulating the expression of BER genes to improve the efficacy of chemopreventives and therapeutics. ..
  72. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2011
    ..The goal of this project is to understand the mechanisms of regulation of BER pathway and devise strategies for modulating the expression of BER genes to improve the efficacy of chemopreventives and therapeutics. ..
  73. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2009
    ..The goal of this project is to understand the mechanisms of regulation of BER pathway and devise strategies for modulating the expression of BER genes to improve the efficacy of chemopreventives and therapeutics. ..
  74. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2010
    ..The goal of this project is to understand the mechanisms of regulation of BER pathway and devise strategies for modulating the expression of BER genes to improve the efficacy of chemopreventives and therapeutics. ..
  75. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2010
    ..How these SSBs are then converted to DSBs is less clear. We have reported that another DNA repair pathway, mismatch repair (MMR) is important for this step, and we will investigate its role...
  76. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2010
    ..How these SSBs are then converted to DSBs is less clear. We have reported that another DNA repair pathway, mismatch repair (MMR) is important for this step, and we will investigate its role...
  77. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Renee Reijo Pera; Fiscal Year: 2000
    DESCRIPTION: This research team has recently created a mouse that is heterozygous for a null mutation in the DNA repair gene XRCC1 (X-ray repair cross-complementing)...
  78. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Roger Pedersen; Fiscal Year: 1999
    DESCRIPTION: This research team has recently created a mouse that is heterozygous for a null mutation in the DNA repair gene XRCC1 (X-ray repair cross-complementing)...
  79. Arsenic-enhanced skin carcinogenesis by UV radiation
    Ke Liu; Fiscal Year: 2009
    ..Although inhibition of DNA repair by arsenite is consistent with the hypothesis that arsenic acts as a co-carcinogen, the actual mechanisms are ..
  80. URACIL/DNA REPAIR IN VITRO AND IN VIVO
    DALE MOSBAUGH; Fiscal Year: 1999
    ..Investigators propose to extend their investigations concerning the mechanism and enzymology of uracil-DNA repair in human and Escherichia coli cells...
  81. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2010
    ..We have found an association between increasing risk of SCCHN and suboptimal DNA repair capacity (DRC) that may be determined by adverse genetic variants such as single nucleotide polymorphisms (SNPs) ..
  82. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2009
    ..We have found an association between increasing risk of SCCHN and suboptimal DNA repair capacity (DRC) that may be determined by adverse genetic variants such as single nucleotide polymorphisms (SNPs) ..
  83. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..We will investigate the links between BER and folic acid that define the seemingly contradictory pro- and anticancer effects of each. ..
  84. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2010
    ..We will investigate the links between BER and folic acid that define the seemingly contradictory pro- and anticancer effects of each. ..
  85. MECHANISMS RESPONSIBLE FOR GENOMIC INSTABILITY IN PREMATURE AGING LAMINOPATHIES
    SUSANA GONZALO HERVAS; Fiscal Year: 2010
    ..Loss of A-type lamins leads to telomere shortening, telomeric chromatin defects, impaired DNA repair, increased genomic instability, and defects in the non-homologous end-joining of dysfunctional telomeres, a ..
  86. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2004
    ..Cells can respond to DNA damage by coordinated induction of DNA repair and it has been shown that differences in the accumulation and removal of DNA lesions in different organs and in ..
  87. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2010
    ..Dynamic FRET will be used to monitor the rates of trapping of unwrapped NCPs by DNA repair proteins at site-specific lesions...
  88. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2002
    ..Cells can respond to DNA damage by coordinated induction of DNA repair and it has been shown that differences in the accumulation and removal of DNA lesions in different organs and in ..
  89. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2011
    ..Dynamic FRET will be used to monitor the rates of trapping of unwrapped NCPs by DNA repair proteins at site-specific lesions...
  90. DNA REPAIR AND SUSCEPTIBILITY TO ENVIRONMENTAL AGENTS
    Ivan Rusyn; Fiscal Year: 2003
    ..Cells can respond to DNA damage by coordinated induction of DNA repair and it has been shown that differences in the accumulation and removal of DNA lesions in different organs and in ..
  91. Impact of MC1R Functional Variants on the DNA Damage Response of Human Melanocyte
    Zalfa Abdel Malek; Fiscal Year: 2009
    ..MC1R signaling, leading to impaired UV-induced DNA damage response of human melanocytes via compromising their DNA repair, antioxidant and melanogenic capacities...
  92. DNA Repair Defects in IgA Deficiency
    REUBEN HARRIS; Fiscal Year: 2009
    b>DNA Repair Defects in IgA Deficiency Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in humans, and it is characterized by the absence of serum IgA and an increased frequency of bacterial infections in the ..
  93. Regulation of Nucleotide Excision Repair by Proteolysis
    Pengbo Zhou; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Nucleotide excision repair (NER) is the major DNA repair machinery that removes DNA damage induced by ultraviolet light (UV) and chemical mutagens to prevent genomic instability and tumorigenesis...
  94. Regulation of Nucleotide Excision Repair by Proteolysis
    Pengbo Zhou; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Nucleotide excision repair (NER) is the major DNA repair machinery that removes DNA damage induced by ultraviolet light (UV) and chemical mutagens to prevent genomic instability and tumorigenesis...
  95. Structural Biochemistry of DNA Dealkylation
    John Tainer; Fiscal Year: 2009
    ..We propose to characterize the structural cell biology of these two key facets of alkylation damage repair, which are directly relevant to improved cancer chemotherapies and risk assessments for environmental agents. ..
  96. Structural Biochemistry of DNA Dealkylation
    John A Tainer; Fiscal Year: 2010
    ..We propose to characterize the structural cell biology of these two key facets of alkylation damage repair, which are directly relevant to improved cancer chemotherapies and risk assessments for environmental agents. ..
  97. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael Smerdon; Fiscal Year: 1999
    The broad objective of this proposal is to understand the molecular details of transcription-coupled DNA repair, an important defense mechanism against phenotypic changes induced by insults to DNA in mammalian cells...
  98. Structural Biochemistry of DNA Dealkylation
    John Tainer; Fiscal Year: 2009
    ..We propose to characterize the structural cell biology of these two key facets of alkylation damage repair, which are directly relevant to improved cancer chemotherapies and risk assessments for environmental agents. ..
  99. RNA Polymerase Transcription Past DNA Adducts
    David A Scicchitano; Fiscal Year: 2011
    ..RNA polymerase behavior during transcription, and to assess the subsequent cellular responses at the level of DNA repair and transcript integrity...
  100. RNA Polymerase Transcription Past DNA Adducts
    David A Scicchitano; Fiscal Year: 2010
    ..RNA polymerase behavior during transcription, and to assess the subsequent cellular responses at the level of DNA repair and transcript integrity...
  101. Role of poly (ADP-ribose)in the Repair of Ultraviolet Induced DNA Damage
    BRENEE SHEMEIR KING; Fiscal Year: 2011
    ..PARP-1) is a zinc-finger protein with many functions within the cell, one in particular being its role in DNA repair pathways...