dna repair

Summary

Summary: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Top Publications

  1. pmc The DNA damage response: making it safe to play with knives
    Alberto Ciccia
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:179-204. 2010
  2. pmc The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    Michael R Lieber
    Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Annu Rev Biochem 79:181-211. 2010
  3. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
  4. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
  5. ncbi Genome maintenance mechanisms for preventing cancer
    J H Hoeijmakers
    MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University, PO Box 1738, 3000DR Rotterdam, The Netherlands
    Nature 411:366-74. 2001
  6. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  7. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  8. ncbi Highly efficient endogenous human gene correction using designed zinc-finger nucleases
    Fyodor D Urnov
    Sangamo BioSciences, Inc, Pt Richmond Tech Center 501, Canal Blvd, Suite A100 Richmond, California 94804, USA
    Nature 435:646-51. 2005
  9. pmc Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    Eleni P Mimitou
    Department of Microbiology, Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
    Nature 455:770-4. 2008
  10. pmc Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    Mary Ellen Moynahan
    Developmental Biology Program, New York, New York 10065, USA
    Nat Rev Mol Cell Biol 11:196-207. 2010

Detail Information

Publications317 found, 100 shown here

  1. pmc The DNA damage response: making it safe to play with knives
    Alberto Ciccia
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:179-204. 2010
    ..This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.
  2. pmc The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    Michael R Lieber
    Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, California 90089, USA
    Annu Rev Biochem 79:181-211. 2010
    ..Therefore, patients lacking normal NHEJ are not only sensitive to ionizing radiation (IR), but also severely immunodeficient...
  3. pmc The DNA-damage response in human biology and disease
    Stephen P Jackson
    The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 461:1071-8. 2009
    ..Our improving understanding of DNA-damage responses is providing new avenues for disease management...
  4. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
    ..These markers include nuclear foci of phosphorylated histone H2AX and their co-localization with DNA repair and DNA damage checkpoint factors such as 53BP1, MDC1 and NBS1...
  5. ncbi Genome maintenance mechanisms for preventing cancer
    J H Hoeijmakers
    MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University, PO Box 1738, 3000DR Rotterdam, The Netherlands
    Nature 411:366-74. 2001
    ..This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis...
  6. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  7. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity...
  8. ncbi Highly efficient endogenous human gene correction using designed zinc-finger nucleases
    Fyodor D Urnov
    Sangamo BioSciences, Inc, Pt Richmond Tech Center 501, Canal Blvd, Suite A100 Richmond, California 94804, USA
    Nature 435:646-51. 2005
    ..We observe comparably high frequencies in human T cells, raising the possibility of strategies based on zinc-finger nucleases for the treatment of disease...
  9. pmc Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    Eleni P Mimitou
    Department of Microbiology, Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
    Nature 455:770-4. 2008
    ..Second, Exo1 and/or Sgs1 rapidly process this intermediate to generate extensive tracts of single-stranded DNA that serve as substrate for Rad51...
  10. pmc Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
    Mary Ellen Moynahan
    Developmental Biology Program, New York, New York 10065, USA
    Nat Rev Mol Cell Biol 11:196-207. 2010
    ..Recent advances have provided a clearer understanding of the connections between these proteins and of the key steps of homologous recombination and DNA strand exchange...
  11. ncbi A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    T T Paull
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Curr Biol 10:886-95. 2000
    ..Recently it has been reported that a member of the histone H2A family, H2AX, becomes extensively phosphorylated within 1-3 minutes of DNA damage and forms foci at break sites...
  12. pmc 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    Peter Bouwman
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Struct Mol Biol 17:688-95. 2010
    ..BRCA1-mutated tumors show genomic instability, mainly as a consequence of impaired recombinatorial DNA repair. Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced ..
  13. doi RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
    Carsten Doil
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark
    Cell 136:435-46. 2009
    ..Thus, RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance...
  14. ncbi Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
    ..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
  15. doi A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
    Cristina Escribano-Diaz
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Mol Cell 49:872-83. 2013
    ..This work therefore identifies a cell cycle-regulated circuit, underpinned by RIF1 and BRCA1, that governs DSB repair pathway choice to ensure that NHEJ dominates in G1 and HR is favored from S phase onward...
  16. doi How shelterin protects mammalian telomeres
    Wilhelm Palm
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Genet 42:301-34. 2008
    ..Recent experiments, discussed here, have revealed how shelterin represses the ATM and ATR kinase signaling pathways and hides chromosome ends from nonhomologous end joining and homology-directed repair...
  17. ncbi Protein modification by SUMO
    Erica S Johnson
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Annu Rev Biochem 73:355-82. 2004
    ..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
  18. doi SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    Chantal Stoepker
    Department of Clinical Genetics, Vrije Universiteit VU Medical Center, Amsterdam, The Netherlands
    Nat Genet 43:138-41. 2011
    ..SLX4, which coordinates three separate endonucleases, was recently recognized as an important regulator of DNA repair. Here we report the first human individuals found to have biallelic mutations in SLX4...
  19. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Surprisingly, four nucleotide excision repair genes were induced, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation...
  20. doi Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
    Barbara van Loon
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    DNA Repair (Amst) 9:604-16. 2010
    ..Here we review the importance of accurate BER of 8-oxo-G damage and its regulation in prevention of cancer...
  21. doi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    ..These data suggest that the importance of ATM signaling for DSB repair increases as the heterochromatic component of a genome expands...
  22. ncbi Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    Raul Mostoslavsky
    Howard Hughes Medical Institute, The Children s Hospital, CBR Institute for Biomedical Research, Harvard University Medical School, Boston, MA 02115, USA
    Cell 124:315-29. 2006
    ..We conclude that one function of SIRT6 is to promote normal DNA repair, and that SIRT6 loss leads to abnormalities in mice that overlap with aging-associated degenerative processes.
  23. doi Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
    Emil Mladenov
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Hufelandstr 55, 45122 Essen, Germany
    Mutat Res 711:61-72. 2011
    ..We place particular emphasis on backup pathways of NHEJ and summarize their increasing significance in various cellular processes, as well as their potential contribution to carcinogenesis...
  24. pmc Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    Andrea Kinner
    Institute of Medical Radiation Biology, University of Duisburg Essen Medical School, Hufelandstrasse 55, 45122 Essen, Germany
    Nucleic Acids Res 36:5678-94. 2008
    ..We conclude with a critical analysis of the strengths and weaknesses of the approach and present some interesting applications of the resulting methodology...
  25. doi Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Nat Rev Mol Cell Biol 9:759-69. 2008
    ....
  26. pmc Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair
    Eva Petermann
    Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK
    Mol Cell 37:492-502. 2010
    ..In conclusion, our data suggest that restart of stalled replication forks and HR repair of collapsed replication forks require two distinct RAD51-mediated pathways...
  27. pmc Transcription as a source of genome instability
    Nayun Kim
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 13:204-14. 2012
    ..Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape...
  28. ncbi Cisplatin: mode of cytotoxic action and molecular basis of resistance
    Zahid H Siddik
    Department of Experimental Therapeutics, Unit 104, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Oncogene 22:7265-79. 2003
    ..The molecular signature defining the resistant phenotype varies between tumors, and the number of resistance mechanisms activated in response to selection pressures dictates the overall extent of cisplatin resistance...
  29. pmc PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    Minli Wang
    University of Duisburg Essen, Medical School, Institute of Medical Radiation Biology, Hufeland Street 55, 45122 Essen, Germany
    Nucleic Acids Res 34:6170-82. 2006
    ..This modification causes a release of PARP-1 from DNA ends and initiates a variety of responses including DNA repair. While PARP-1 has been firmly implicated in base excision and single strand break repair, its role in the repair ..
  30. pmc Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases
    Dennis Castor
    MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Cell 52:221-33. 2013
    ..These findings shed light on HJ resolution in mammals and on maintenance of genome stability. ..
  31. ncbi Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    Eros Lazzerini Denchi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 448:1068-71. 2007
    ..The results reveal how mammalian telomeres use multiple mechanisms to avoid DNA damage surveillance and provide an explanation for the induction of replicative senescence and genome instability by shortened telomeres...
  32. ncbi Cellular processing of platinum anticancer drugs
    Dong Wang
    Department of Chemistry, Massachusetts Institute of Technology, Room 18 498, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 4:307-20. 2005
    ..those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death...
  33. pmc DNA interstrand crosslink repair and cancer
    Andrew J Deans
    London Research Institute, Cancer Research UK, Clare Hall Laboratories, South Mimms EN63LD, UK
    Nat Rev Cancer 11:467-80. 2011
    ..Understanding how the FA pathway links nucleases, helicases and other DNA-processing enzymes should lead to more targeted uses of ICL-inducing agents in cancer treatment and could provide novel insights into drug resistance...
  34. ncbi Topoisomerase I inhibitors: camptothecins and beyond
    Yves Pommier
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892 4255, USA
    Nat Rev Cancer 6:789-802. 2006
    ....
  35. pmc Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
    Thomas O Auer
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Genome Res 24:142-53. 2014
    ..Due to its simplicity, flexibility, and very high efficiency, our method greatly expands the repertoire for genome editing in zebrafish and can be readily adapted to many other organisms. ..
  36. ncbi ATM and related protein kinases: safeguarding genome integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Cancer 3:155-68. 2003
    ..Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers...
  37. doi RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis
    Natsuko Suwaki
    The Cancer Research UK Medical Research Council Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK
    Semin Cell Dev Biol 22:898-905. 2011
    ..and consisting of five proteins (RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3), play an essential role in the DNA repair reactions through HR...
  38. doi Principles of ubiquitin and SUMO modifications in DNA repair
    Steven Bergink
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 458:461-7. 2009
    ....
  39. pmc Shining a light on xeroderma pigmentosum
    John J DiGiovanna
    DNA Repair Section, Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    J Invest Dermatol 132:785-96. 2012
    Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair characterized by sun sensitivity and UV radiation-induced skin and mucous membrane cancers...
  40. pmc Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
    Valerie Garcia
    Genome Damage and Stability Centre, The University of Sussex, Brighton, BN1 9RQ, UK
    Nature 479:241-4. 2011
    ..Mre11 exonuclease activity also confers resistance to DNA damage in cycling cells, suggesting that Mre11-catalysed resection may be a general feature of various DNA repair pathways.
  41. pmc Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells
    Teresa Neumaier
    Institute of Radiation Protection, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 109:443-8. 2012
    ....
  42. pmc DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
    Burkhard Jakob
    Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Planckstrasse 1, 64291 Darmstadt, Germany
    Nucleic Acids Res 39:6489-99. 2011
    ..Finally, we describe a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces...
  43. ncbi Regulation of DNA double-strand break repair pathway choice
    Meena Shrivastav
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, USA
    Cell Res 18:134-47. 2008
    ....
  44. pmc Y-family DNA polymerases and their role in tolerance of cellular DNA damage
    Julian E Sale
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Rev Mol Cell Biol 13:141-52. 2012
    ..However, as they exhibit low fidelity when copying undamaged DNA, it is essential that they are only called into play when they are absolutely required. Several layers of regulation ensure that this is achieved...
  45. ncbi Chk1 and Chk2 kinases in checkpoint control and cancer
    Jiri Bartek
    Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Cancer Cell 3:421-9. 2003
    ..This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways...
  46. pmc RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
    Frédérick A Mallette
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    EMBO J 31:1865-78. 2012
    In response to DNA damage, cells initiate complex signalling cascades leading to growth arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ..
  47. ncbi Expandable DNA repeats and human disease
    Sergei M Mirkin
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    Nature 447:932-40. 2007
    ..It is becoming clear that the peculiar structures of repeat-containing transcripts are at the heart of the pathogenesis of these diseases...
  48. ncbi DNA double-strand breaks: signaling, repair and the cancer connection
    K K Khanna
    The Queensland Institute of Medical Research, and Department of Pathology, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Nat Genet 27:247-54. 2001
    ..the transcriptional and post-transcriptional activation of a subset of genes including those associated with DNA repair, and, under some circumstances, the triggering of programmed cell death...
  49. ncbi gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization
    Markus Lobrich
    Darmstadt University of Technology, Radiation Biology and DNA Repair, Darmstadt, Germany
    Cell Cycle 9:662-9. 2010
    ..We discuss the limitations and benefits of the technique, enabling the procedure to be optimally exploited but not misused...
  50. pmc Targeting DNA topoisomerase II in cancer chemotherapy
    John L Nitiss
    Molecular Pharmacology Department, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Nat Rev Cancer 9:338-50. 2009
    ..These studies promise refined targeting of TOP2 as an effective anticancer strategy...
  51. ncbi Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    Hannah Farmer
    Cancer Research UK Gene Function and Regulation Group, London, UK
    Nature 434:917-21. 2005
    ..These results illustrate how different pathways cooperate to repair damage, and suggest that the targeted inhibition of particular DNA repair pathways may allow the design of specific and less toxic therapies for cancer.
  52. doi The DNA damage response and cancer therapy
    Christopher J Lord
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Nature 481:287-94. 2012
    ..pervasive characteristics of tumour cells and is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells...
  53. ncbi Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    Aziz Sancar
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Annu Rev Biochem 73:39-85. 2004
    ..b>DNA repair mechanisms include direct repair, base excision repair, nucleotide excision repair, double-strand break repair, ..
  54. pmc Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    Brandi L Mahaney
    Department of Biochemistry and Molecular Biology and The Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Biochem J 417:639-50. 2009
    ..In the present review, we will discuss our current understanding of the mechanism of NHEJ in mammalian cells and discuss the roles of DNA-PKcs and DNA-PK-mediated phosphorylation in NHEJ...
  55. pmc Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
    Anand G Patel
    Department of Molecular Pharmacology and Experimental Therapeutics, Radiation Oncology, and Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 108:3406-11. 2011
    ....
  56. pmc BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    Amitabh V Nimonkar
    Department of Microbiology, University of California at Davis, Davis, California 95616, USA
    Genes Dev 25:350-62. 2011
    ..BLM increases the affinity of EXO1 for ends, and MRN recruits and enhances the processivity of EXO1. Our results establish two of the core machineries that initiate recombinational DNA repair in human cells.
  57. pmc XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    A J Pierce
    Cell Biology Program, Memorial Sloan Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Genes Dev 13:2633-8. 1999
    ..These results establish that XRCC3-mediated homologous recombination can reverse DNA damage that would otherwise be mutagenic or lethal...
  58. ncbi Poly(ADP-ribose): novel functions for an old molecule
    Valerie Schreiber
    Département Intégrité du Génome de l UMR 7175, Centre National de la Recherche Scientifique, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard S Brant, BP 10413, F 67412 Illkirch cedex, France
    Nat Rev Mol Cell Biol 7:517-28. 2006
    ..These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism...
  59. doi Mutation of the RAD51C gene in a Fanconi anemia-like disorder
    Fiona Vaz
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, London, UK
    Nat Genet 42:406-9. 2010
    ..RAD51C is a member of the RAD51-like gene family involved in homologous recombination-mediated DNA repair. The mutation results in loss of RAD51 focus formation in response to DNA damage and in increased cellular ..
  60. doi Repeat instability as the basis for human diseases and as a potential target for therapy
    Arturo López Castel
    Program of Genetics and Genome Biology, The Hospital for Sick Children, 101 College Avenue, East Tower 15 312, TMDT Toronto, Ontario, Canada, M5G 1L7
    Nat Rev Mol Cell Biol 11:165-70. 2010
    ....
  61. doi Cyclical DNA methylation of a transcriptionally active promoter
    Raphaël Métivier
    Universite de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu, 35042 Rennes Cedex, France
    Nature 452:45-50. 2008
    ..Cyclical changes in the methylation status of promoter CpGs may thus represent a critical event in transcriptional achievement...
  62. pmc Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
    Agata Smogorzewska
    Department of Genetics, Howard Hughes Medical Institute, Center for Genetics and Genomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:289-301. 2007
    ..Mutation in FANCI is responsible for loss of a functional FA pathway in a patient with Fanconi anemia complementation group I...
  63. ncbi Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
    Marzena Bienko
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Science 310:1821-4. 2005
    ..Our results indicate that Ub-binding domains of Y-family polymerases play crucial regulatory roles in TLS...
  64. pmc DNA repair mechanisms in dividing and non-dividing cells
    Teruaki Iyama
    Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    DNA Repair (Amst) 12:620-36. 2013
    ..To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain ..
  65. pmc Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
    Kyle M Miller
    The Gurdon Institute, University of Cambridge, Cambridge, UK
    Nat Struct Mol Biol 17:1144-51. 2010
    ....
  66. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
    ....
  67. ncbi Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    Lee Zou
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1542-8. 2003
    ..Our data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling...
  68. doi DNA repair in mammalian cells : Nucleotide excision repair: variations on versatility
    T Nouspikel
    Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom
    Cell Mol Life Sci 66:994-1009. 2009
    Nucleotide excision repair (NER) is one of the most versatile DNA repair systems...
  69. pmc MicroRNA regulation of DNA repair gene expression in hypoxic stress
    Meredith E Crosby
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Cancer Res 69:1221-9. 2009
    ..Bioinformatics analyses suggested that these miRs could regulate factors implicated in DNA repair pathways...
  70. doi SIRT6 promotes DNA repair under stress by activating PARP1
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 332:1443-6. 2011
    ....
  71. pmc Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes
    Ovidiu Popa
    Institute of Botany III, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Genome Res 21:599-609. 2011
    ..revealed that recipient genomes of distant transfers encode proteins of nonhomologous end-joining (NHEJ; a DNA repair mechanism) far more frequently than the recipient lacking that mechanism...
  72. pmc ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    Claudia Cosentino
    Genome Stability Unit, Clare Laboratories, London Research Institute, Cancer Research UK, South Mimms, UK
    EMBO J 30:546-55. 2011
    ..These data suggest that ATM protects cells from ROS accumulation by stimulating NADPH production and promoting the synthesis of nucleotides required for the repair of DSBs...
  73. pmc A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
    Danny M Chou
    Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:18475-80. 2010
    ..and mass spectrometry to uncover proteins that associate with damaged DNA, many of which are involved in DNA repair or nucleolar function...
  74. pmc The MRE11 complex: starting from the ends
    Travis H Stracker
    Institute for Research in Biomedicine Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Spain
    Nat Rev Mol Cell Biol 12:90-103. 2011
    ..damage response (DDR), which is a functional network comprising signal transduction, cell cycle regulation and DNA repair. The metabolism of DNA double-strand breaks governed by the DDR is important for preventing genomic alterations ..
  75. pmc Pathways of DNA double-strand break repair during the mammalian cell cycle
    Kai Rothkamm
    Fachrichtung Biophysik, Universitat des Saarlandes, D 66421 Homburg Saar, Germany
    Mol Cell Biol 23:5706-15. 2003
    ..These data provide the first evaluation of the cell cycle-specific contributions of NHEJ and HR to the repair of radiation-induced versus replication-associated DSBs...
  76. pmc Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2
    Craig MacKay
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Cell 142:65-76. 2010
    ..Depletion of FAN1 from human cells causes hypersensitivity to ICLs, defects in ICL repair, and genome instability. These data at least partly explain how ubiquitination of FANCD2 promotes DNA repair.
  77. doi MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    Mitch McVey
    Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
    Trends Genet 24:529-38. 2008
    ..We propose a mechanistic model for MMEJ and highlight important questions for future research...
  78. pmc Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis
    Min Xian Qian
    Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, and College of Life Sciences, Beijing Normal University, 19 XinJieKouWai Avenue, Beijing 100875, China
    Cell 153:1012-24. 2013
    Histone acetylation plays critical roles in chromatin remodeling, DNA repair, and epigenetic regulation of gene expression, but the underlying mechanisms are unclear...
  79. ncbi Oxidative DNA damage: mechanisms, mutation, and disease
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    FASEB J 17:1195-214. 2003
    ....
  80. doi DNA damage response and transcription
    Saskia Lagerwerf
    Department of Toxicogenetics, Leiden University Medical Center, 2333 RC Leiden, The Netherlands
    DNA Repair (Amst) 10:743-50. 2011
    ....
  81. doi The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, United Kingdom
    DNA Repair (Amst) 9:1273-82. 2010
    ..Collectively, these recent studies highlight not only how chromatin complexity influences the factors required for DSB repair but also the pathway choice...
  82. pmc Human SIRT6 promotes DNA end resection through CtIP deacetylation
    Abderrahmane Kaidi
    Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 329:1348-53. 2010
    ..These findings further clarify how SIRT6 promotes genome stability...
  83. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
    ..complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man...
  84. pmc A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling
    Cecilia Cotta-Ramusino
    Department of Genetics, Harvard University Medical School, Howard Hughes Medical Institute, Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 332:1313-7. 2011
    The DNA damage response (DDR) is brought about by a protein kinase cascade that orchestrates DNA repair through transcriptional and posttranslational mechanisms. Cell cycle arrest is a hallmark of the DDR...
  85. doi Maintaining genome stability at the replication fork
    Dana Branzei
    Fondazione IFOM, Istituto FIRC di Oncologia Molecolare, IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Nat Rev Mol Cell Biol 11:208-19. 2010
    ..These mechanisms ensure that the local DNA damage response, which enables replication fork progression and DNA repair in S phase, is coupled with cell cycle transitions...
  86. pmc Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    Pablo Huertas
    Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    J Biol Chem 284:9558-65. 2009
    ..These results suggest that CDK-mediated control of resection in human cells operates by mechanisms similar to those recently established in yeast...
  87. doi ATM activation by oxidative stress
    Zhi Guo
    Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, and Institute for Cellular and Molecular Biology ICMB, University of Texas at Austin, Austin, TX 78712, USA
    Science 330:517-21. 2010
    ..mutated (ATM) protein kinase is activated by DNA double-strand breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and orchestrates signaling cascades that initiate the DNA damage response...
  88. doi More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
    Jiri Lukas
    Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nat Cell Biol 13:1161-9. 2011
    ..Recent research has provided insights into these issues and suggests that chromatin responses induced by DNA damage are not simply the accumulation of 'nuclear foci' but are mechanisms required to guard genome integrity...
  89. pmc Regulation of homologous recombination in eukaryotes
    Wolf Dietrich Heyer
    Department of Microbiology, University of California, Davis, Davis, California 95616 8665, USA
    Annu Rev Genet 44:113-39. 2010
    ..Here, we review the factors and mechanistic stages of recombination that are subject to regulation and suggest that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates...
  90. doi The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    Joanne Smith
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Adv Cancer Res 108:73-112. 2010
    ..In response to DSBs, ATM is required both for ATR-Chk1 activation and to initiate DNA repair via homologous recombination (HRR) by promoting formation of single-stranded DNA at sites of damage through ..
  91. pmc Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
    Samira Fekairi
    Genome Instability and Carcinogenesis UPR3081 CNRS, Conventionné par l Université d Aix Marseille 2, IGC, IMM 31 chemin Joseph Aiguier, 13402 Marseille, France
    Cell 138:78-89. 2009
    Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination...
  92. doi DNA repair pathways as targets for cancer therapy
    Thomas Helleday
    Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Nat Rev Cancer 8:193-204. 2008
    b>DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging ..
  93. pmc ERCC1 isoform expression and DNA repair in non-small-cell lung cancer
    Luc Friboulet
    INSERM Unité 981, and Département Hospitalo Universitaire Thorax Innovation, Institut Gustave Roussy, Villejuif, France
    N Engl J Med 368:1101-10. 2013
    ..Although several ongoing trials are evaluating the level of expression of ERCC1, no consensus has been reached regarding a method for evaluation...
  94. ncbi DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    Ken A Olaussen
    Laboratory of Radiobiology and Oncology, Commissariat a l Energie Atomique, Fontenay aux Roses, University of Paris 11, Paris, France
    N Engl J Med 355:983-91. 2006
    ..Adjuvant cisplatin-based chemotherapy improves survival among patients with completely resected non-small-cell lung cancer, but there is no validated clinical or biologic predictor of the benefit of chemotherapy...
  95. ncbi Human DNA repair genes
    R D Wood
    Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
    Science 291:1284-9. 2001
    ..Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here...
  96. pmc Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    Q Liu
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:1448-59. 2000
    ..Taken together, these data indicate that Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression, and that Atr regulates Chk1...
  97. pmc Purified human BRCA2 stimulates RAD51-mediated recombination
    Ryan B Jensen
    Department of Microbiology, University of California, Davis, California 95616, USA
    Nature 467:678-83. 2010
    ..report the purification of full-length BRCA2 and show that it both binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA)...
  98. pmc Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
    Sophie E Polo
    The Gurdon Institute, Department of Biochemistry, University of Cambridge, Cambridge CB21QN, United Kingdom
    Genes Dev 25:409-33. 2011
    ..We review these regulatory mechanisms and discuss their biological significance to the DDR...
  99. ncbi Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    Helen E Bryant
    The Institute for Cancer Studies, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Nature 434:913-7. 2005
    Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the site of damage. Nevertheless, PARP1-/- mice are viable, fertile and do not develop early onset tumours...
  100. pmc Human CtIP promotes DNA end resection
    Alessandro A Sartori
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 450:509-14. 2007
    ..These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination...
  101. pmc Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
    Hyungjin Kim
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
    Genes Dev 26:1393-408. 2012
    ..Central to this pathway is the monoubiquitination of FANCD2, which coordinates multiple DNA repair activities required for the resolution of ICLs...

Research Grants118 found, 100 shown here

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..the cardiomyocyte that cleaved myofibrils (4-6) and nuclear matrix protein poly ADP-ribose polymerase (PARP)-a DNA repair enzyme in cell survival during I/R (7). However, the regulation of intracellular MMPs during I/R is not known...
  3. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..These DNA lesions activate a multifaceted DNA damage response (DDR) to promote DNA repair by respective single and double strand break repair pathways (SSBR and DSBR)...
  4. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..essential selenoprotein with defined roles in redox regulation of cell growth, death (apoptosis), transcription, DNA repair, and angiogenesis...
  5. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..nitrosating species induce DNA single strand breaks that activate poly(ADP-ribose) polymerase (PARP), a nuclear DNA repair enzyme that in turn depletes its substrate NAD, resulting in an exhaustion of intracellular energetics, ATP ..
  6. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..oxidative and nitrosative species that in turn induce DNA single strand breakage and triggering of the nuclear DNA repair enzyme, poly(ADP-ribose) polymerase-1 (PARP-1)...
  7. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..effects of a hyperosmolal bladder microenvironment on the DNA damage response pathway, to assess the efficacy of DNA repair under a hyperosmolal bladder microenvironment, and to evaluate the activation of cell cycle checkpoints and ..
  8. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..recently been associated with the DNA damage response, and appears to promote efficient cell cycle arrest and DNA repair after damage1...
  9. Targeting Inflammation for the Amelioration of Cisplatin-Hearing Loss
    Vickram Ramkumar; Fiscal Year: 2011
    ..However, inhibition of caspases, p53, or activation of DNA repair enzymes may promote the development of tumors or promote tumor chemoresistance...
  10. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..The DNA repair enzyme that recognizes and excises 8-oxodG is 8- oxoG-DNA glycosylase (OGG1)...
  11. Molecular Mechanisms of Parvovirus Gene Expression and Replication
    Jianming Qiu; Fiscal Year: 2013
    ..machinery to replicate its ssDNA genome;rather, it appears to induce a DDR and subsequently co-opts the host DNA repair mechanism to facilitate its own replication...
  12. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Additionally, we identified an ICSBP-target-gene involved in a key DNA repair pathway in hematopoietic cells (Fanconi F)...
  13. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..When this genomic injury is then recognized by the nuclear DNA repair enzyme poly (ADP-ribose) polymerase ("PARP"), NAD is cleaved to generate the product poly(ADP-ribose)...
  14. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..responses to DNA double strand breaks, and it is required for activation of cell cycle checkpoints, direct DNA repair events and/or apoptosis...
  15. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..Recent research has established the importance of Fanconi anemia genes in tumor suppression, DNA repair, stem cell function, and suppression of apoptosis and senescence, survival, leukemogenesis and carcinogenesis, ..
  16. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..Recent research has established the importance of Fanconi anemia genes in tumor suppression, DNA repair, stem cell function, and suppression of apoptosis and senescence;thus, advances made in FA science have an ..
  17. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..gene has multiple functions needed for the cellular response to DNA damage, including cell cycle checkpoints, DNA repair and pro-apoptotic activities. In addition, RAD9 can, like p53, act as a sequence specific transcription factor...
  18. Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Pierre Alexandre Vidi; Fiscal Year: 2013
    ..My career goal is to expand my current mentored project on DNA repair, initiated three years ago, as an academic principal investigator and to develop innovative strategies to fight ..
  19. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..A potential underlying molecular mechanism for these diseases is suggested by the study of DNA repair-deficient mouse models that lack oxidative DNA base damage repair and exhibit many of the defining hallmarks of ..
  20. CHEMISTRY AND BIOLOGY OF PLATINUM ANTICANCER DRUGS
    Stephen J Lippard; Fiscal Year: 2013
    ..The knowledge acquired will be used to design, synthesize, and evaluate new anticancer drug candidates for targeting and destroying tumors. ..
  21. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..stress, cells activate complex protein kinase signaling pathways, such as ATM, to arrest the cell cycle, recruit DNA repair machinery, and re-enter the cell cycle once the damage is resolved, or if the damage is overwhelming, induce ..
  22. Molecular Epidemiology of DNA Repair in Head and Neck Cancer
    Qingyi Wei; Fiscal Year: 2012
    ..The long- term goal of this study is to identify effective biomarkers that can be used to identify at-risk individuals who will be targeted for primary prevention and early detection of SCCHN in the general population. ..
  23. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..We will investigate the links between BER and folic acid that define the seemingly contradictory pro- and anticancer effects of each. ..
  24. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..R-503 is both 1) a potent inhibitor of the nuclear DNA repair enzyme poly(ADP-ribose) polymeras ("PARP") (IC50=20 nM), and 2) a dihydrolipoate ("DHL")-based redox catalyst ..
  25. Regulation of Genomic and Epigenomic Stability at CpG Sites
    Alfonso Bellacosa; Fiscal Year: 2013
    ..shed light on the emerging link between genomic and epigenomic stability at CpG sites and the employment of the DNA repair machinery to effect DNA demethylation...
  26. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..efflux, inactivation, altered expression of pro/anti-apoptotic proteins or tumor suppressor genes, and increased DNA repair mechanisms...
  27. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..modification that affects chromatin structure and regulates diverse cellular functions, such as gene expression, DNA repair, and cell proliferation...
  28. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..Both nuclear and mitochondrial DNA repair mechanisms exist, although less is known about mitochondrial repair...
  29. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..When this genomic injury is then recognized by the nuclear DNA repair enzyme poly(ADP-ribose) polymerase ("PARP"), NAD is cleaved to generate the product poly(ADP-ribose)...
  30. Mechanism(s) of Hepatocyte Transformation by the Hepatitis B Virus X Protein
    Ourania M Andrisani; Fiscal Year: 2013
    ..SUZ12 and ZNF198 mediate chromatin remodeling and associate with PML nuclear bodies (NBs) that regulate DNA repair, apoptosis and viral replication...
  31. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..the generation of peroxynitrite via broad-spectrum redox catalysis, and 2) competitively inhibits the nuclear DNA repair enzyme poly(ADP-ribose) polymerase 1 ("PARP- 1")...
  32. Hepatitis B virus replication and DDB1
    Betty L Slagle; Fiscal Year: 2013
    ..DDB1 regulates diverse cellular functions such as DNA replication, cell cycle, innate immunity, and damaged DNA repair. We hypothesize that HBx acts as a viral DCAF, and displaces one or more cellular DCAFs from the Cul4-DDB1 ..
  33. Role of poly (ADP-ribose) polymerase 1 (PARP-1) in experimental colitis
    Claire Larmonier; Fiscal Year: 2013
    ..a family of 18 cell signaling enzymes, which are involved in the regulation of DNA-binding proteins and DNA repair. These enzymes catalyze the transfer of ADP-ribose units from NAD+ to a number of acceptor proteins (by a ..
  34. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    ..genes, many with likely important roles in liver disease risk including controlling cellular inflammation and DNA repair. Experimental data suggests the AR and also its androgen ligands including the primary male sex hormone ..
  35. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..changes with microRNAs (miRNAs) serving as regulators for a series of cell stress response proteins and DNA repair enzymes that ultimately trigger cell death in cancer but not normal cells...
  36. DNA REPAIR IN A HORMONE RESPONSIVE GENE
    Michael J Smerdon; Fiscal Year: 2013
    ..Dynamic FRET will be used to monitor the rates of trapping of unwrapped NCPs by DNA repair proteins at site-specific lesions...
  37. Neonatal Chemoselection Following Ex Vivo Gene Transfer For Hereditary Disorders
    KARIN L GAENSLER; Fiscal Year: 2012
    ..This variant DNA repair enzyme confers resistance to benzylguanine, an inhibitor of endogenous MGMT, and to chloroethylating agents such ..
  38. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..We will also define the contribution of radiation-induced cell cycle arrest, DNA repair and apoptosis to taste cell renewal following injury...
  39. Evaluating the role of histone H3K79 methylation states in DNA damage repair in S
    Jeffrey S Thompson; Fiscal Year: 2010
    ..Dysfunction of these systems is the root cause of a variety of DNA damage sensitivity disorders in humans. DNA repair in eukaryotic organisms is influenced by a family of highly conserved proteins called histones, which serve to ..
  40. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..ERCC1-XPF protein complex is a highly conserved endonuclease that is required for at least two DNA repair mechanisms: nucleotide excision repair (NER) and DNA interstrand crosslink repair...
  41. The role of LKB1 in the maintenance of genomic stability.
    Zhi Xiang Xu; Fiscal Year: 2013
    ..LKB1-deficient cells exhibit a delayed DDR and reduced DNA repair after exposure to ionizing radiation (IR)...
  42. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ..of DNA damage, PARP will cause the cell to preferentially undergo a necrotic cell death pathway rather than DNA repair or apoptosis. Necrotic cells release proinflammatory mediators into surrounding tissues, propagating injury...
  43. NAD Metabolism and Signaling
    Frances E Lund; Fiscal Year: 2011
    ..contribute to its synthesis and salvage are now known to be global regulators in key aspects of biology from DNA repair to gene transcription and from cancer biology to aging...
  44. CONTROL OF EUCARYOTIC FUNCTION BY METHYLATION
    Steven G Clarke; Fiscal Year: 2013
    ..residue to interact with RNA, DNA, and protein partners and have been shown to have roles in gene regulation, DNA repair, and intracellular signaling pathways...
  45. PROBES FOR CYTOMETRY
    Zbigniew Darzynkiewicz; Fiscal Year: 2013
    ..These assays will find utility in studies of DNA damage, DNA repair, carcinogenesis/mutagenesis, apoptosis, and in identifying the mechanism of action of antitumor drugs...
  46. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
    ..In response to DNA damage, cells use similar checkpoint mechanisms to halt cell cycle for DNA repair, or trigger cell death if the damage is beyond repair...
  47. Inactivation of Hdac3 in the cause, prevention, and treatment of HCC
    Scott W Hiebert; Fiscal Year: 2013
    ..provided by applicant): Histone deacetylases regulate chromatin structure, transcription, replication, and DNA repair/recombination...
  48. Arsenic co-carcinogenesis with UVR: nitrosation and oxidation of target proteins
    Ke Jian Liu; Fiscal Year: 2013
    ..potential of other genotoxic agents such as ultraviolet radiation, at least in part, through inhibition of DNA repair processes...
  49. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    ..Studies of meiosis have yielded insights into fundamental cell processes, including DNA repair, chromosome dynamics, and cell cycle regulation...
  50. Metnase, PIKK, and RPA Roles in DNA Damage and Replication Stress Responses
    Jac A Nickoloff; Fiscal Year: 2013
    ..Normal and tumor cells respond to DNA damage and associated replication stress by activating DNA repair, cell cycle arrest (checkpoint) systems, and when damage is severe, programmed death pathways, collectively ..
  51. Molecular Determinants of DNA Sliding and Hopping by a DNA Repair Glycosylase
    MENG MENG ROWLAND; Fiscal Year: 2013
    ....
  52. Novel therapies for Fanconi anemia
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..FA cells have a defect in DNA repair that leads to increased spontaneous chromosomal breakage...
  53. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    ..In previous studies we reported that key antioxidant and DNA repair genes are regulated differently in normal bronchial epithelial cells (NBEC) of lung cancer cases compared to non-..
  54. The Role of hPso4 in DNA Repair and Chemotherapy Resistance
    Montaser Shaheen; Fiscal Year: 2013
    ..There is data to indicate a role of Pso4 in DNA repair from yeast to humans. Saccharomyces cerevisiae Mutant pso4...
  55. Cellular functions of the essential PcrA helicase in Staphylococcus aureus
    Saleem A Khan; Fiscal Year: 2013
    ..PcrA is related to the Escherichia coli UvrD and Rep helicases and is known to be essential for UV DNA repair in Bacillus subtilis. In B...
  56. Regulation of HIV-1 by Rad51 in CNS cells
    Kamel Khalili; Fiscal Year: 2013
    ..interaction of HIV-1 with cellular pathways that control chromosomal integrity via homologous and non-homologous DNA repair. While the role of HIV-1 Vpr in affecting DNA damage is well documented, recent observations (shown here) point ..
  57. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium
    Grover Bagby; Fiscal Year: 2009
    ..Recent research has established the importance of Fanconi anemia genes in tumor suppression, DNA repair, stem cell function, and suppression of apoptosis and senescence;thus, advances made in FA science have an ..
  58. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..effect, as the pre-DNA damage co-localization properties of the V(D)J recombinase were re- established upon DNA repair. Moreover, the IR-induced redistribution of the V(D)J recombinase was blocked by addition of an inhibitor to DNA ..
  59. Stem cell mutagenesis mediated by age and niche
    VIVIENNE ILONA REBEL; Fiscal Year: 2011
    ..integrity in the different tissues is maintained during aging is limited largely to analyses of DNA damage, DNA repair, and mutagenesis in differentiated cells and tissues...
  60. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..SIRT1 is the best studied. Major processes controlled by SIRT1 include DNA repair, protein folding, fatty acid and glucose metabolism, hypoxic responses, autophagy, and anti-apoptotic mechanisms...
  61. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..is sufficient to stimulate carcinogen-associated mutation and recombination, the transcriptional induction of DNA repair genes after AFB1 exposure, and AFB1-associated activation of the checkpoint gene Rad53 (CHK2)...
  62. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    ..We identified genes involved in 1) DNA replication and mitotic progression, 2) DNA repair and 3) p53 function...
  63. The role fo the TPP1 peotein in telomerase function and cancer cell survival
    Jayakrishnan Nandakumar; Fiscal Year: 2013
    ..protein folding, then, as a graduate student I employed biochemistry and x-ray crystallography to study RNA/DNA repair, and now, working as a post-doc with Dr...
  64. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..Furthermore, this knowledge will allow us eventually to devise strategies for modulating MPG expression for chemopreventive and therapeutic purposes. ..
  65. Checkpoints and double strand breaks in S. pombe meiosis
    Susan L Forsburg; Fiscal Year: 2013
    ..kinase Hsk1 and its subunit Dfp1 (ScCdc7, ScDbf4) which normally preserve replication fork integrity and promote DNA repair, instead actively promote double strand break formation during meiosis...
  66. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..cancer;(6) mechanisms that control genomic integrity including DNA replication checkpoints and post-replication DNA repair;(7) novel approaches including genomics, systems biology, and single molecule studies...
  67. Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
    Lopa Mishra; Fiscal Year: 2013
    ..However, sensors for genotoxicity leading to aberrant DNA repair remain elusive...
  68. Defining the role of proteostasis pathways in cancer drug resistance
    ERICA LYNN CAIN; Fiscal Year: 2013
    ..Both Breast Cancer 2 susceptibility protein (BRCA2) and PARP1 function in DNA repair. Loss-of-function of either gene is not lethal, however, loss of both leads to an accumulation of double-strand ..
  69. Study DNA repair in preventing MDS and AML after radiation and benzene exposure
    EDWARD PAUL HASTY; Fiscal Year: 2013
    ..In support, people with certain DNA repair defective syndromes including Fanconi anemia (FA) and Bloom syndrome (BS) exhibit MDS...
  70. Development of Novel Agents Targeting Genome Stability and Maintenance for Treati
    John J Turchi; Fiscal Year: 2013
    ..Both intrinsically and acquired resistant EOC often display alterations in DNA repair or damage tolerance and thus inhibition of DNA repair pathways holds the potential to sensitize these cells to ..
  71. Establishment of sister chromatid cohesion
    Douglas E Koshland; Fiscal Year: 2013
    ..Chromosomes are organized into morphologically distinct higher-order structures during chromosome segregation, DNA repair, and transcription...
  72. Role of Non-Core RAG1 in DSB Repair, Cell Survival, and Cell Cycle Progression
    Julie Horowitz; Fiscal Year: 2013
    ..Further, I will test the ability of non-core Rag1 regions to facilitate DNA repair via promoting H2AX phosphorylation and H2AX, H2A, and H2B ubiquitylation following RAG DSBs...
  73. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    ..to ask whether compensatory biological mechanisms exist that might couple vitamin D photosynthesis to the DNA repair pathways relevant for ultraviolet radiation (UV)...
  74. ROLES AND REGULATION OF P53
    Carol Prives; Fiscal Year: 2013
    ..Levine will also study the roles of SNPs in p63 or p73 that influence DNA repair systems in female eggs and copy number variation that affect cancer in offspring Scott Lowe will continue to ..
  75. Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis
    Raul Mostoslavsky; Fiscal Year: 2013
    ..Recently, we discovered that the mammalian SIRT6 is a chromatin factor that influences glucose metabolism and DNA repair. In mice, SIRT6-deficiency provokes a profound and lethal hypoglycemia which culminates in accelerated death...
  76. Characterization of lung cancer radiosensitizers from genome-wide RNAi screens
    David Kozono; Fiscal Year: 2013
    ..D., and I sought mentorship under Dr. Alan D'Andrea to study DNA repair biology...
  77. Mitochondrial DNA Repair and Biogenesis
    Raquel R Bartz; Fiscal Year: 2013
    ..The PI will investigate the role of the mitochondrial DNA repair (mDNA) enzyme, OGG1 and nuclear coactivators, PGC-11 and its family members, in mtDNA maintenance and biogenesis ..
  78. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    ..of GBMs are not responsive due to the resistance mediated by O6-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that limits the radiosensitizing and cytotoxic effects of TMZ...
  79. Oxidative DNA base damage and repair at telomeres and the relevance to cell senes
    PATRICIA LYNN OPRESKO; Fiscal Year: 2013
    ..The results will pave the way for future work examining how telomeric damage and repair change with age and vary with cell type, and should lead to new strategies for preserving telomere function to promote healthy aging. ! ..
  80. Targeted Degradation of DNA Damage Response Proteins by Autophagy
    Thomas J Begley; Fiscal Year: 2013
    ..Fortunately, cells can respond to DNA damage by regulating gene expression to coordinate proper DNA repair, replication, cell cycle and metabolism. Years of work in S...
  81. Cell cycle checkpoint defects lead to chronic inflammation in RA
    Thomas M Aune; Fiscal Year: 2013
    ..Activation of cell cycle checkpoints and the DNA repair machinery repairs DNA damage...
  82. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    ..rescued oocytes by whole genome sequencing of offspring and genetic analyses of potential alternative DNA repair pathways...
  83. Epigenetic control of sex chromosome behavior in meiosis.
    JoAnne Engebrecht; Fiscal Year: 2013
    ..Here we will also probe the physical interactions between chromatin, chromatin modifiers, DNA repair and checkpoint proteins...
  84. The role of Mc1r in melanocytic UV-induced DNA damage and repair responses
    JOHN A DORAZIO; Fiscal Year: 2013
    ..Together, these studies will lay the foundation for future translational studies designed to develop novel small molecule-based approaches for UV and cancer protection to prevent many cases of melanoma. ..
  85. CHROMATIN MODIFYING FACTORS CONTROL RADIATION RESPONSE AND GENOMIC STABILITY
    Tej K Pandita; Fiscal Year: 2013
    ..A major impediment in the mammalian DNA repair field to answering this type of question has been the non-specificity of DNA damage inducing agents (for example:..
  86. Bacteriophage Control of DNA Repair in Streptococcus Pyogenes
    WILLIAM MICHAEL MCSHAN; Fiscal Year: 2013
    ..This research will determine the role of a bacterial virus in regulating a key DNA repair system...
  87. MECHANISMS RESPONSIBLE FOR GENOMIC INSTABILITY IN PREMATURE AGING LAMINOPATHIES
    SUSANA GONZALO HERVAS; Fiscal Year: 2013
    ..Loss of A-type lamins leads to telomere shortening, telomeric chromatin defects, impaired DNA repair, increased genomic instability, and defects in the non-homologous end-joining of dysfunctional telomeres, a ..
  88. In vivo detection and genome-wide location analysis of DNA-adducts
    Stephen B Howell; Fiscal Year: 2013
    ..While mechanisms underlying sensitivity, agent homeostasis, detoxification, DNA repair and apoptosis, have been well investigated, the central molecular event, the formation of adducts, is not well ..
  89. Targeting Rad6 Postreplication DNA Repair to Treat Triple Negative Breast Cancer
    Malathy P V Shekhar; Fiscal Year: 2013
    ..BRCA1-associated BrCas have aberrant DNA repair, and since TNBCs share several histologic features with BRCA1-related BrCa, DNA repair pathways are thought to ..
  90. Novel Strategy to Sensitize Prostate Cancer Cells to Radiation
    Marja T Nevalainen; Fiscal Year: 2013
    ..damage in PCa cells and 7) Stat5a/b up-regulates Rad51 which is the key protein in Homologous Recombination (HR)-DNA repair in mammalian cells...
  91. Novel approaches to enhance tumor cell cytotoxicity of alkylating agents
    Robert W Sobol; Fiscal Year: 2013
    ..Insights gained from these studies have the potential to identify novel targets for adjuvant therapies including BER inhibitors and NAD+ biosynthesis modulators that can be combined with alkylators to improve anticancer drug efficacy. ..
  92. Understanding the role of PCNA in DNA mismatch repair subpathways
    EVA MARIE GOELLNER; Fiscal Year: 2013
    ..Understanding DNA repair pathways is also critical given that many chemotherapeutic agents function by damaging DNA...
  93. DNA Repair Enzymes for the Prevention of Skin Cancer
    Amanda K McCullough; Fiscal Year: 2013
    ..Restoration Genetics, Inc (RGI) has developed and patented technologies activating a second, nuclear- targeted DNA repair pathway, base excision repair, for the removal of the primary DNA lesions caused by sunlight exposure, ..
  94. Mechanisms of SIRT2 Function in the Replication Stress Response
    David Yu; Fiscal Year: 2013
    ..RSR) recognizes challenges to DNA replication from insults such as ionizing radiation and coordinates diverse DNA repair and cell cycle checkpoint pathways necessary to maintain genome integrity...
  95. A novel role for PARP1 in regulation of autophagy
    Gen Sheng Wu; Fiscal Year: 2013
    ..provided by applicant): An extensive literature documents the role of poly(ADP-ribose)polymerase 1 (PARP1) in DNA repair. PARP1 recognizes and is activated by single strand DNA breaks...
  96. Studying the role of the nuclear lamina in age dependent demyelination
    Quasar S Padiath; Fiscal Year: 2013
    ..integrity of the nucleus and has roles in essential cellular processes including transcription, DNA replication, DNA repair, and epigenetic regulation...
  97. The Meningioma Consortium: Genome-Wide Association Study
    Elizabeth B Claus; Fiscal Year: 2013
    ..gene) and 4) Replicate previous associations from the Tineas Capitas study of meningioma risk with variants in DNA repair genes (KRAS2, ERCC2, CCND1)...
  98. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David A Boothman; Fiscal Year: 2013
    ..Tumor-specificity to DNA repair inhibitors will resul in dramatic NAD+/ATP losses and inhibition of glucose metabolism and DNA repair...
  99. Cellular Responses to DNA Replication Stress
    Marcus Smolka; Fiscal Year: 2013
    ..replication factor Dpb11 (ortholog of human TopBP1) with Slx4, a scaffold protein that coordinates the action of DNA repair factors...
  100. Targeting nucleotide excision repair in combination cancer therapy
    John J Turchi; Fiscal Year: 2013
    ..Our previous data identified two classes of RPA inhibitors, both of which decrease ..
  101. Analysis of the Mammalian DNA Damage Response
    Stephen J Elledge; Fiscal Year: 2013
    ..In addition, it directly orchestrates DNA repair choices because senses different DNA damage structures and transduces that information in cis to activate ..