Genomes and Genes
Summary: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.
Publications199 found, 100 shown here
- Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene contentJennifer F Hughes
Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 463:536-9. 2010The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over with the X chromosome...
- Y chromosomes: born to be destroyedSigrid Steinemann
Institut für Molekulargenetik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
Bioessays 27:1076-83. 2005..They are more exposed to the decay process. (5) Gene dosage balance is re-established by the parallel evolution of dosage compensation mechanisms...
- Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)C K Hamilton
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Sex Dev 3:205-13. 2009Multi-copied gene families are prevalent in mammalian genomes, especially within the Y chromosome. Testis specific protein Y-encoded (TSPY) is present in variable copy number in many mammalian species...
- Novel gene acquisition on carnivore Y chromosomesWilliam J Murphy
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
PLoS Genet 2:e43. 2006Despite its importance in harboring genes critical for spermatogenesis and male-specific functions, the Y chromosome has been largely excluded as a priority in recent mammalian genome sequencing projects...
- Re-sequencing regions of the ovine Y chromosome in domestic and wild sheep reveals novel paternal haplotypesJ R S Meadows
CSIRO Livestock Industries, 306 Carmody Road, St Lucia, QLD 4067, Australia
Anim Genet 40:119-23. 2009The male-specific region of the ovine Y chromosome (MSY) remains poorly characterized, yet sequence variants from this region have the potential to reveal the wild progenitor of domestic sheep or examples of domestic and wild paternal ..
- A radiation hybrid map for the bovine Y ChromosomeWan-Sheng Liu
Department of Animal Science, College of Agricultural, Food, and Environmental Sciences, University of Minnesota, 305 Haecker Hall, 1364 Eckles Avenue, St. Paul 55108, USA
Mamm Genome 13:320-6. 2002Screening a bovine Y Chromosome-specific DNA library resulted in 34 new microsatellites, six of which mapped to the pseudoautosomal region (PAR), and 28 localized to the Y-specific region...
- Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosomeAlison J Pearks Wilkerson
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
Genomics 92:329-38. 2008..As a consequence of random decay and chromosome rearrangements over evolutionary time, Y chromosome gene repertoires differ between eutherian lineages...
- Low conservation of gene content in the Drosophila Y chromosomeLeonardo B Koerich
Departamento de Genetica, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944 970, Rio de Janeiro, Brazil
Nature 456:949-51. 2008..melanogaster Y chromosome is much younger...
- Origin and evolution of Y chromosomes: Drosophila talesA Bernardo Carvalho
Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Trends Genet 25:270-7. 2009..Surprisingly, the majority of Drosophila Y-linked genes are recent acquisitions from autosomes and Y chromosome gene gains are more frequent than gene losses...
- Sex chromosomes of basal placental mammalsPaul D Waters
Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
Chromosoma 116:511-8. 2007....
- Geographic origin of the Y chromosomes in "old" inbred strains of miceP K Tucker
Jackson Laboratory, Bar Harbor, Maine 04609
Mamm Genome 3:254-61. 1992..musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains...
- Organization and expression of rat TspyF Dechend
Institut fur Humangenetik, Medizinische Hochschule, Hannover, Germany
Cytogenet Cell Genet 83:270-4. 1998....
- The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARsT Raudsepp
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
Cytogenet Genome Res 121:102-9. 2008..Although striking differences like those observed between human and mouse may be rare, variations similar to those seen between horse and human may be prevalent among mammals...
- A view of modern human origins from Y chromosome microsatellite variationM Seielstad
Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115 6096 USA
Genome Res 9:558-67. 1999..We analyze variation at 10 Y chromosome microsatellite loci that were typed in 506 males representing 49 populations and every inhabited continent and ..
- Unequal rates of Y chromosome gene divergence during speciation of the family UrsidaeShigeki Nakagome
Division of Biological Science, Graduate School of Science, Hokkaido University, Sapporo, Japan
Mol Biol Evol 25:1344-56. 2008..variation among genes with different modes of inheritance: matrilineal mitochondrial DNA (mtDNA), patrilineal Y chromosome, biparentally inherited autosomes, and the X chromosome...
- The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspectiveO Semino
Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
Science 290:1155-9. 2000A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied...
- Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosomeR J Van Golde
Departments of Obstetrics and Gynaecology, Human Genetics and Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands
Hum Reprod 16:289-92. 2001Microdeletions of the azoospermia factor (AZF) region of the Y chromosome occur in between 1 and 29% of oligozoospermic and azoospermic men, and most deletions are found in the AZFc region...
- Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J miceKaren M Spach
Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 182:1789-93. 2009..To determine whether the Y chromosome contributes to this sexual dimorphism, EAE was induced in consomic SJL/J mice carrying a B10...
- Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogasterDebashish U Menon
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
Genetics 183:811-20. 2009..Genetic tests indicate that the effect on male survival depends upon the presence and source of the Y chromosome, revealing a germ line imprint that influences dosage compensation...
- Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouseS Mazeyrat
INSERM U406, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
Hum Mol Genet 7:557-62. 1998..Y chromosomes generally do not recombine along most of their length, and thus Y chromosome genes, despite having been selectively maintained for their function, could be lost from the genome...
- Y-specific microsatellites reveal an African subfamily in taurine (Bos taurus) cattleL Pérez-Pardal
Área de Genética y Reproducción Animal, SERIDA, Camino de los Claveles 604 33203 Gijón, Spain
Anim Genet 41:232-41. 2010..However, Y-specific microsatellites increased analytical resolution and allowed at least two different Y2-haplotypic subfamilies to be distinguished, one of them restricted to the African continent...
- Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein geneR Reijo
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02142, USA
Nat Genet 10:383-93. 1995We have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with azoospermia (no sperm in semen). No Y deletions were detected in their male relatives or in 90 other fertile males...
- The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomesE C Salido
Howard Hughes Medical Institute, University of California School of Medicine, Harbor UCLA Medical Center, Torrance
Am J Hum Genet 50:303-16. 1992....
- Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long armD J Elliott
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
Proc Natl Acad Sci U S A 94:3848-53. 1997The association of abnormal spermatogenesis in men with Y chromosome deletions suggests that genes important for spermatogenesis have been removed from these individuals...
- The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprintingKeith A Maggert
The Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Genetics 162:1245-58. 2002..We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila melanogaster and found that all but one location showed differential expression of one or both ..
- Governing sex determination in fish: regulatory putsches and ephemeral dictatorsJ N Volff
Department of Physiological Chemistry I, University of Wurzburg, Wurzburg, Germany
Sex Dev 1:85-99. 2007..has been formed through duplication of the autosomal gene dmrt1 onto another autosome, thus generating a new Y chromosome. Dmrt1bY emerged about 10 million years ago and is restricted to several Oryzias species, indicating that the Y ..
- Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequencesBernardo Lemos
Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Science 319:91-3. 2008The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila contrasts with data indicating that this chromosome has polymorphic phenotypic effects on sex ratio, temperature sensitivity, behavior, and fitness...
- Assignment of SRY, ANT3, and CSF2RA to the bovine Y chromosome by FISH and RH mappingWan Sheng Liu
Department of Animal Biotechnology, College of Agriculture, Biotechnology, and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
Anim Biotechnol 15:103-9. 2004Three genes, SRY, ANT3, and CSF2RA, were mapped to the bovine Y chromosome (BTAY) by fluorescence in situ hybridization (FISH) and/or radiation hybrid (RH) mapping...
- Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomesAnne Sophie Van Laere
Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
Genome Res 18:1884-95. 2008..that it maps to the 5' end of the GPR143 gene, which has concomitantly lost upstream noncoding exons on the Y chromosome. We show that the bovine PAB was created approximately 20...
- Evidence for degeneration of the Y chromosome in the dioecious plant Silene latifoliaGabriel A B Marais
Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, 69622 Villeurbanne Cedex, France
Curr Biol 18:545-9. 2008..There are clear signs of degeneration in the Drosophila miranda neoY chromosome (an autosome fused to the Y chromosome), with neoY genes showing faster protein evolution [3-6], accumulation of unpreferred codons , more ..
- An evolutionary witness: the frog rana rugosa underwent change of heterogametic sex from XY male to ZW femaleI Miura
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Hiroshima, Japan
Sex Dev 1:323-31. 2007..Change of the heterogametic sex will also be discussed, relating data from frogs (Rana) and other animals to the replacement of a master sex-determining gene in the course of speciation...
- Endothelial cell chimerism after renal transplantation and vascular rejectionE L Lagaaij
Department of Pathology, Leiden University Medical Centre, The Netherlands
Lancet 357:33-7. 2001..The endothelium in the blood vessels is thought to be the major target for graft rejection. Endothelial cells of a transplanted organ are believed to remain of donor origin after transplantation. We aimed to verify this concept...
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifA H Sinclair
Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
Nature 346:240-4. 1990A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene...
- The degeneration of Y chromosomesB Charlesworth
Institute for Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
Philos Trans R Soc Lond B Biol Sci 355:1563-72. 2000..It is, however, currently unclear which of the various processes is most important; some directions for future work to help to resolve this question are discussed...
- Differences in recombination frequencies during female and male meioses of the sex chromosomes of the medaka, Oryzias latipesM Kondo
Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Genet Res 78:23-30. 2001..curvinotus, a species related to the medaka. These markers could be used for genotyping the sex chromosomes in the medaka and other species, and could be used in other studies on sex chromosomes...
- X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouseJohn R McCarrey
Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
Genesis 34:257-66. 2002....
- Y chromosome haplotype analysis in Portuguese cattle breeds using SNPs and STRsCatarina Ginja
Instituto Superior de Agronomia, Tapada da Ajuda, Lisboa, Portugal
J Hered 100:148-57. 2009..were tested for 5 single nucleotide polymorphisms, 1 "indel," and 7 microsatellites specific to the Y chromosome. The 13 Y-haplotypes defined included 3 previously described patrilines (Y1, Y2, and Y3) and 10 new haplotypes ..
- The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determinationA Pask
Department of Genetics and Evolution, La Trobe University, Melbourne 3083, Australia
Proc Natl Acad Sci U S A 97:13198-202. 2000..There is no evidence for a Y-borne ATRX homologue in mouse or human, implying that this gene has been lost in eutherians and its role supplanted by the evolution of SRY from SOX3 as the dominant determiner of male differentiation...
- Evolution of X-degenerate Y chromosome genes in greater apes: conservation of gene content in human and gorilla, but not chimpanzeeHiroki Goto
Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
J Mol Evol 68:134-44. 2009Compared with the X chromosome, the mammalian Y chromosome is considerably diminished in size and has lost most of its ancestral genes during evolution...
- Y chromosome conserved anchored tagged sequences (YCATS) for the analysis of mammalian male-specific DNALinda Hellborg
Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, , SE-752 36 Uppsala, Sweden
Mol Ecol 12:283-91. 2003b>Y chromosome haplotyping based on microsatellites or single nucleotide polymorphisms has recently proven to be a powerful approach for evolutionary studies of human populations, and also holds great promise for the studies of wild species...
- Mammalian sex--Origin and evolution of the Y chromosome and SRYPaul D Waters
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, GPO Box 475, ACT 2601, Canberra, Australia
Semin Cell Dev Biol 18:389-400. 2007..In this review we will discuss the organization and evolution of the sex chromosomes across a broad range of mammals, and speculate on how the Y chromosome, and SRY, evolved.
- A 7-bp insertion in the 3' untranslated region suggests the duplication and concerted evolution of the rabbit SRY geneArmando Geraldes
CIBIO, , , , e Departamento de Zoologia e Antropologia, , 4099-002 Porto, Portugal
Genet Sel Evol 38:313-20. 2006..In addition, the remarkable observation of haplotypes exhibiting 0, 1 and 2 7-bp inserts in essentially all algirus populations suggests that the rabbit SRY gene is duplicated and evolving under concerted evolution...
- The sexually transmitted genomeKen McElreavey
, Institut Pasteur, Paris 75724, France
Trends Genet 18:13-4. 2002
- A novel repeated sequence located on the bovine Y chromosome: its application to rapid and precise embryo sexing by PCRSoichi Kageyama
Hokkaido Animal Research Center, Shintoku, Japan
J Vet Med Sci 66:509-14. 2004..FISH analysis showed that S4 is localized on the whole long arm and the proximal region of the short arm of the Y chromosome. We found that a PCR primer set for S4 amplified a male-specific 178 bp product in addition to a 145 bp product ..
- Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific functionDaniel J Park
Department of Zoology, The University of Melbourne, Melbourne VIC 3010, Australia
Gene 362:29-36. 2005Many or most genes on the mammal Y chromosome evolved a testis-specific function after diverging from an X-borne copy with a general function in both sexes...
- A probe generated by chromosome microdissection, useful for analyzing Y chromosome evolution in Old World monkeysTakahiro Taguchi
Department of Anatomy, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
Chromosome Res 11:147-52. 2003We isolated a DNA probe, designated MMDYZ1, using a chromosome microdissection technique from the Y chromosome of the Rhesus monkey...
- Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian populationG Passarino
Department of Genetics, Stanford University, Stanford, CA, USA
Hum Hered 52:136-9. 2001We have analyzed a sample of 40 centenarians and 116 young controls from Sardinia, with a set of new Y chromosome binary markers, to evaluate if Y chromosome genes are involved in the high prevalence of males among centenarian Sardinians (..
- Highly efficient sex chromosome interchanges produced by I-CreI expression in DrosophilaKeith A Maggert
Department of Biology, University of Utah, Salt Lake City, Utah 84112
Genetics 171:1103-14. 2005..This method has advantages over the traditional use of X rays for generating X-Y interchanges because it is very frequent and it generates predictable products...
- Evidence for different origins of sex chromosomes in closely related Oryzias fishes: substitution of the master sex-determining geneKeita Tanaka
Niigata University, Japan
Genetics 177:2075-81. 2007..The medaka sex-determining gene DMY has been identified on the orthologous Y chromosome [O. latipes linkage group 1 (LG1)] of O. curvinotus...
- Shared Y chromosome repetitive DNA sequences in stallion and donkey as visualized using whole-genomic comparative hybridizationJ Gosalvez
Department of Biology, Genetics Unit, Universidad Autonoma de Madrid, Madrid, Spain
Eur J Histochem 54:e2. 2010..genomic in situ hybridization (W-CGH) technique, with special reference to the variability observed in the Y chromosome. Results show that these diverging genomes still share some highly repetitive DNA families localized in ..
- A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogenyH S Kim
Department of Cellular and Molecular Biology, Kyoto University, Aichi, Japan
Am J Phys Anthropol 100:301-9. 1996..024, 0.048, and 0.094, respectively. The rates of nucleotide substitutions per site per year were higher in the TSPY intron than in the TSPY exon, and higher in the TSPY intron than in the ZFY (Zinc Finger Y) intron in human and apes...
- Non-invasive genetic monitoring of wild central chimpanzeesMimi Arandjelovic
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
PLoS ONE 6:e14761. 2011..Genotyping non-invasively collected faecal samples is an effective way of evaluating a species' population size without disruption, and can also reveal details concerning population structure...
- A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigensA I Agulnik
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103
Hum Mol Genet 3:873-8. 1994A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermatogenesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, ..
- Multiple paternal origins of domestic cattle revealed by Y-specific interspersed multilocus microsatellitesL Pérez-Pardal
Área de Genética y Reproducción Animal, SERIDA, Camino de Rioseco, Camino de Rioseco 1225, Gijon, Asturias, Spain
Heredity (Edinb) 105:511-9. 2010....
- Transposition of RhoA to the murine Y chromosomeH L Boettger-Tong
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
Genomics 49:180-7. 1998In an effort to produce a more complete transcription map of the short (approximately 5 Mb) arm of the mouse Y chromosome, we have initiated exon trapping from Yp-derived YACs...
- Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markersE Hagelberg
Department of Genetics, University of Cambridge, UK
Philos Trans R Soc Lond B Biol Sci 354:141-52. 1999..Our results show that the demographic expansion of the Austronesians has left a genetic footprint. However, there is no simple correlation between languages and genes in the Pacific...
- The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenesN Levy
INSERM U491, Génétique Médicale et Développement, Faculte de Medecine de la Timone, Marseille, France
Mamm Genome 11:164-8. 2000
- Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversalB Capel
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
Nat Genet 5:301-7. 1993An approach designed to map and generate mutations in the region of the short arm of the mouse Y chromosome, known to be involved in sex determination and spermatogenesis, is described...
- Genome analysis: More Drosophila Y chromosome genesB Charlesworth
Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
Curr Biol 11:R182-4. 2001The Drosophila melanogaster Y chromosome has long been known to contain few functional genes other than several required for male fertility. The D...
- Structure and evolution of mtanga, a retrotransposon actively expressed on the Y chromosome of the African malaria vector Anopheles gambiaeCherise J B Rohr
Department of Biological Sciences, University of Notre Dame, IN 46556, USA
Mol Biol Evol 19:149-62. 2002..discovery of a novel family of long terminal repeat (LTR)-retrotransposons designated mtanga-Y, specific to the Y chromosome of the African malaria vector, Anopheles gambiae...
- Genealogical and evolutionary inference with the human Y chromosomeM P Stumpf
Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
Science 291:1738-42. 2001..Because model-free and model-based approaches have different biases and limitations, we conclude that there is considerable benefit in the continued use of both types of approaches...
- The sex-determining region of the human Y chromosome encodes a finger proteinD C Page
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
Cell 51:1091-104. 1987The presence or absence of the Y chromosome determines whether a mammalian embryo develops as a male or female...
- The program of sex chromosome pairing in meiosis is highly conserved across marsupial species: implications for sex chromosome evolutionJesús Page
Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago 7
Genetics 170:793-9. 2005..This situation could have influenced the further evolution of sex chromosomes in marsupials...
- A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plantsMichael Nicolas
, ENS Lyon, France
PLoS Biol 3:e4. 2005....
- Chromosome banding in Amphibia. XXIX. The primitive XY/XX sex chromosomes of Hyla femoralis (Anura, Hylidae)M Schmid
Department of Human Genetics, Biocenter, University of Wurzburg, Wurzburg, Germany
Cytogenet Genome Res 101:74-9. 2003..The consequences of the loss of about 50% of ribosomal RNA genes for the viability of male individuals and spermatogenesis are discussed...
- Replication banding and FISH analysis reveal the origin of the Hyla femoralis karyotype and XY/XX sex chromosomesJ E Wiley
Department of Pediatrics, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
Cytogenet Genome Res 101:80-3. 2003..The X chromosome is distinguished by having a nucleolar organizing region (NOR) in the short arm. The Y chromosome does not possess an NOR...
- In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomesFrank Grützner
Research School of Biological Sciences, Australian National University, GPO Box 475, Canberra, Australian Capital Territory 2601, Australia
Nature 432:913-7. 2004..This suggests an evolutionary link between mammal and bird sex chromosome systems, which were previously thought to have evolved independently...
- Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mappingTerje Raudsepp
Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Proc Natl Acad Sci U S A 101:2386-91. 2004....
- The evolution of a neo-XY1Y2 sex chromosome system by autosome-sex chromosome fusion in Dundocoris nodulicarinus Jacobs (Heteroptera: Aradidae: Carventinae)D H Jacobs
Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
Chromosome Res 12:175-91. 2004..The evolution and behaviour of the karyotypes and sex chromosome systems during the course of meiosis in the subspecies of D. nodulicarinus are described, discussed and illustrated...
- Evolutionary breakpoint analysis on Y chromosomes of higher primates provides insight into human Y evolutionR Wimmer
Institute of Human Genetics and Anthropology, University of Freiburg, Germany
Cytogenet Genome Res 108:204-10. 2005..21 to metaphases of human and great apes unravels breakpoints that were involved in species-specific Y chromosome evolution...
- The evolution of the azoospermia factor region AZFa in higher primatesR Wimmer
Institute of Human Genetics and Anthropology, University of Freiburg, Germany
Cytogenet Genome Res 108:211-6. 2005..3 and Yp13.2, respectively. Regarding the order of PAC clones and genes within the AZFa region, no differences could be detected between apes and man, indicating a strong evolutionary stability of this non-recombining region...
- Non-random chromosome positioning in mammalian sperm nuclei, with migration of the sex chromosomes during late spermatogenesisHelen A Foster
Laboratory of Nuclear and Genomic Health, Cell and Chromosome Biology Group, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, UB8 3PH, UK
J Cell Sci 118:1811-20. 2005..This study reveals the temporal repositioning of chromosome territories in spermatogenesis...
- Evolutionary history of Silene latifolia sex chromosomes revealed by genetic mapping of four genesDmitry A Filatov
School of Biosciences, University of Birmingham, Edgbaston, UK
Genetics 170:975-9. 2005..between the homologous X- and Y-linked copies of these genes supports the "evolutionary strata" model, with at least three consecutive expansions of the nonrecombining region on the Y chromosome (NRY) in this plant species.
- A case of an intersex horse with 63,X/64,XX/65,XX,del(Y)(q?) karyotypeM Bugno
Department of Immuno and Cytogenetics, National Research Institute of Animal Production, Balice Kraków Equine Hospital in Gliwice, Gliwice, Poland
Cytogenet Genome Res 120:123-6. 2008..The X and Y chromosome painting probes detected three cell lines in the examined horse: 63,X, 64,XX and 65,XX with a fragment of a Y ..
- Characterization of a chromosomal rearrangement responsible for producing "apparent" XY-female fall-run Chinook salmon in CaliforniaKevin S Williamson
National Marine Fisheries Service, Northwest Fisheries Science Center, Conservation Biology Division, 2725 Montlake Boulevard East, Seattle, WA 98112, USA
J Hered 99:483-90. 2008..FISH analyses suggest that apparent XY-female fall-run Chinook salmon in California are not the product of a Y chromosome to autosome translocation...
- Cytogenetic study of Anopheles albitarsis (Diptera: Culicidae) by C-banding and in situ hybridizationM S Rafael
Coordenação de Pesquisas em Ciências da Saúde, Instituto Nacional de Pesquisas da Amazonia, Manaus, AM, Brazil
Hereditas 143:62-7. 2006..These findings of the populations studied support the hypothesis that the stability of NORs in the A. albitarsis complex is characterized by the presence of clustered and conserved sites in a unique pair of chromosomes...
- Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medakaMariko Kondo
Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, D-97074 Wuerzburg, Germany
Genome Res 16:815-26. 2006Sequencing of the human Y chromosome has uncovered the peculiarities of the genomic organization of a heterogametic sex chromosome of old evolutionary age, and has led to many insights into the evolutionary changes that occurred during ..
- Sex chromosome chimerism and the freemartin syndrome in Rideau Arcott sheepM D Brace
Department of Biomedical Science, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
Cytogenet Genome Res 120:132-9. 2008..Moreover, as it was shown that opposite sex cells can migrate to tissues other than blood and be transcriptionally active in chimeric sheep, we speculate on the role they can play in these animals...
- Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatidsJames M A Turner
Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Dev Cell 10:521-9. 2006..While this postmeiotic repression occurs after the loss of MSUC-related proteins at the end of prophase, other histone modifications associated with transcriptional repression have by then become established...
- Microsatellites reveal male recombination and neo-sex chromosome formation in Scaptodrosophila hibisci (Drosophilidae)Alex C C Wilson
Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
Genet Res 87:33-43. 2006..We describe how an autosomal fission followed by fusion of one of the autosomal fragments to the Y chromosome to create a Y1Y2X1X2/X1X1X2X2 sex determination system provides the most parsimonious explanation of the ..
- Chimerism analysis following nonmyeloablative stem cell transplantationThomas Lion
Children's Cancer Research Institute, Vienna, Austria
Methods Mol Med 125:275-95. 2006..Moreover, cell subset-specific analysis permits the assessment of impending complications at a significantly higher sensitivity, thus providing a basis for earlier treatment decisions...
- Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolutionPaul D Waters
Comparative Genomics Group, Research Group of Biological Science, The Australian National University, Canberra, ACT, 2601, Australia
Chromosome Res 13:401-10. 2005..Since these genes lie on the X in marsupials and eutherians, and also on the homologous region of chicken chromosome 4, this represents a loss from the monotreme X rather than an additional evolutionary stratum of the human X...
- Coupling and decoupling of evolutionary mode between X- and Y-chromosomal red-green opsin genes in owl monkeysKenji Nagao
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Seimeitou #502, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan
Gene 352:82-91. 2005....
- A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorterYun Tao
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
PLoS Biol 5:e293. 2007..We postulate that recurrent bouts of sex-ratio meiotic drive and its subsequent suppression might underlie several common features observed in the heterogametic sex, including meiotic sex chromosome inactivation and achiasmy...
- Chromosome banding in Amphibia. XXVIII. Homomorphic XY sex chromosomes and a derived Y-autosome translocation in Eleutherodactylus riveroi (Anura, Leptodactylidae)M Schmid
Department of Human Genetics, Biocenter, University of Wurzburg, Wurzburg, Germany
Cytogenet Genome Res 101:62-73. 2003..The XAA(Y) karyotype originated by a centric (Robertsonian) fusion between the original, free Y chromosome and an autosome. 46.2% of the male individuals in this population are carriers of this Y-autosome fusion...
- A comparative genomic hybridization study in a 46,XX maleM Angels Rigola
Unitat de Biologia, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, , Barcelona, Spain
Fertil Steril 78:186-8. 2002OBJECTIVE: To identify Y chromosome material in an azoospermic male with an XX karyotype.DESIGN: Case report. SETTING: Faculty of medicine and Centro de Patologia Celular (CPC) medical center...
- Xp22.3; Yq11.2 chromosome translocation and its clinical manifestationsS G Frints
Center for Human Genetics, University of Leuven, Belgium
Ann Genet 44:71-6. 2001..The manifestations in male and female with loss of the Xp22.3-->pter and gain of the Yq11.21-->qter chromosomal region are discussed...
- A mola hydatidosa coexistent with a foetus in a bovine freemartin pregnancyB Meinecke
Department of Reproductive Medicine, Buenteweg 15, School of Veterinary Medicine Hannover, Germany
Placenta 24:107-12. 2003..Furthermore, the present observation demonstrates that the freemartin condition in cattle can be induced even in cases where severe placental transformations had subsequently occurred and no foetus proper could be detected at delivery...
- B chromosomes of Korean field mouse Apodemus peninsulae (Rodentia, Murinae) analysed by microdissection and FISHT V Karamysheva
Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
Cytogenet Genome Res 96:154-60. 2002..On the basis of comparative analysis of localization of B chromosome repeats in the chromosomes of two related species, A. peninsulae and A. agrarius, we suggest a hypothesis of B chromosome origin and evolution in the genus Apodemus...
- Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndromeX Lowe
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Am J Hum Genet 69:1046-54. 2001..These findings suggest that older fathers produce higher frequencies of XY sperm, which may place them at higher risk of fathering boys with Klinefelter syndrome, and that age effects on sperm aneuploidy are chromosome specific...
- A mapping and evolutionary study of porcine sex chromosome genesClaire R Quilter
Human Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Mamm Genome 13:588-94. 2002..This suggests that the order of the X/Y homologous genes of the porcine X and Y Chrs may closely resemble the ancestral gene order of the eutherian sex chromosomes...
- No intraindividual variation of disomy rate in sperm samplesAliza Amiel
Genetic Institute, Meir Hospital, Kfar Saba 44281, Israel
J Hum Genet 47:539-42. 2002..These results suggest that the sampling time has no importance in assessing the rate of nondisjunction in sperm cells...
- Absence of sperm sex chromosome aneuploidies in an X0/XYY manBrian Dale
Centre for Reproductive Biology, Clinica Villa del Sole, Naples, Italy
Fertil Steril 78:634-6. 2002..Sex chromosome aneuploidies may be eliminated in the testes through the selective degeneration of abnormal spermatogenic cells...
- The location of Z- and W-linked marker genes and sequence on the homomorphic sex chromosomes of the ostrich and the emuA Ogawa
Laboratory of Molecular Biology, Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 Japan
Proc Natl Acad Sci U S A 95:4415-8. 1998..In the female ostrich, however, the sequence of the gene for the iron-responsive element-binding protein was missing from one of the pairs, thus revealing the differentiation by a small deletion of the W from the Z...
- Survival of transplanted human corneal stem cells. Case reportUlf Stenevi
Department of Ophthalmology, Sahlgren University Hospital, Molndal, Sweden
Acta Ophthalmol Scand 80:105-8. 2002..To report a case history involving long-term survival of transplanted human corneal stem cells...
- Biopsied testis cells of four 47,XXY patients: fluorescence in-situ hybridization and ICSI resultsMarianne Bergere
Department of Reproductive Biology and Cytogenetics, CHI Poissy Saint Germain, 78303 Poissy, Paris Ouest University, France
Hum Reprod 17:32-7. 2002....
- Rate of homologous chromosome bivalents in spermatocytes may predict completion of spermatogenesis in azoospermic menLeah Yogev
The Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann St Tel Aviv 64239, Israel
Hum Genet 110:30-5. 2002..A high rate of X-Y bivalents may impel one to continue with testicular open biopsies...
- Detection of fetal cells in intrauterine lavage samples collected in the first trimester of pregnancyRiccardo Cioni
Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Florence, Italy
Prenat Diagn 22:52-5. 2002....
- Hypomethylated X chromosome gain and rare isochromosome 12p in diverse intracranial germ cell tumorsYoshifumi Okada
Department of Pathology and Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Neuropathol Exp Neurol 61:531-8. 2002..germ cell tumors and the predisposition in Klinefelter syndrome patients for these lesions, the data argue strongly that sex chromosome aberrations, rather than isochromosome 12p, are integral to intracranial germ cell tumorigenesis..
- The Ceratitis capitata homologue of the Drosophila sex-determining gene sex-lethal is structurally conserved, but not sex-specifically regulatedG Saccone
Dipartimento di Genetica, Biologia generale e Moleculare, Universita degli Studi di Napoli Federico II, Napoli, Italy
Development 125:1495-500. 1998..Our findings suggest that Sxl acquired its master regulatory role in sex determination during evolution of the Acalyptratae group, most probably after phylogenetic divergence of the genus Drosophila from other genera of this group...
- Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementationKevin Eggan
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Nat Biotechnol 20:455-9. 2002..We show that the Y chromosome is lost in 2% of subclones from 40,XY ES cell lines, making the identification of targeted 39,X0 subclones a ..
- Novel genomic effects of Y-linked polymorphismsDaniel L Hartl; Fiscal Year: 2010..The novelty emerges from our recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many ..
- Gender Bias in Lupus: Contribution of Sex ChromosomesRam Raj Singh; Fiscal Year: 2010..effect on disease outcomes and immune measures in Aims 1 and 2 is attributable to a gene unique to the Y chromosome versus the dosage of X genes...
- Gender Bias in Lupus: Contribution of Sex ChromosomesRam Raj Singh; Fiscal Year: 2010..effect on disease outcomes and immune measures in Aims 1 and 2 is attributable to a gene unique to the Y chromosome versus the dosage of X genes...
- Mechanisms of Sex Determination in ZebrafishJOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010....
- Microarray Analysis of H-Y Antibodies in Human TransplantationDavid Miklos; Fiscal Year: 2007..Female donor H-Y reactivity will be correlated with male recipient clinical outcomes, and male recipient H-Y antibody epitope specificity thereby testing an H-Y B cell adoptive transfer hypothesis. ..
- MOUSE X-CHROMOSOME INACTIVATIONChristine Disteche; Fiscal Year: 2003..Evolution of the mammalian sex chromosomes is characterized by degeneration of the Y chromosome, once sex was determined by a gene on the Y chromosome and recombination was inhibited...
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..These will include measures of semen quality, ratio of X/Y chromosome-bearing sperm, chromatin stability of the sperm, sex ratio of births, and waiting time to pregnancy...
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPhilippe Grandjean; Fiscal Year: 2007..These will include measures of semen quality, ratio of X/Y chromosome-bearing sperm, chromatin stability of the sperm, sex ratio of births, and waiting time to pregnancy...
- Genomics of Pediatric Headache DisordersAndrew Hershey; Fiscal Year: 2006..The results of this study should help in beginning to develop a molecular genomic approach for the diagnosis and treatment of different headache disorders. ..
- SPECIES BOUNDARIES IN THE ANOPHELES GAMBIAE COMPLEXNora Besansky; Fiscal Year: 2003..gambia complex. The Y chromosome provides a powerful tool to attack questions at the population level and above, not only because it is ..
- Molecular Evolution of Drosophila Y ChromosomeANDREW G contact CLARK; Fiscal Year: 2010Because the Y chromosome is present in just one copy and only in males, it faces a diminished capacity to purge deleterious mutations...
- Pre-Clinical Trial of MSC-Based Therapy for CNS DiseaseDONALD PHINNEY; Fiscal Year: 2007..b>Y chromosome. To confirm the real-time PCR data engrafted MSCs will be visualized in brain sections by immunofluorescent ..
- Male Reproductive Effects from Exposure to BoronWendie Robbins; Fiscal Year: 2005..toxicity on male reproduction: total sperm count, sperm density, viability, motility, morphology, and sperm X:Y chromosome ratios sperm chromatin integrity measured by sperm chromatin structure assay (SCSA), COMET, TUNEL, protamine 1 (..
- Validating Sexual Behavior by Y-chromosome PCRJonathan Zenilman; Fiscal Year: 2005..Since Yc sampling requires only a vaginal swab, and is stable under field conditions, this test promises to be a practical and easily used biomarker for sexual behavior research. ..