y chromosome

Summary

Summary: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.

Top Publications

  1. ncbi DMY is a Y-specific DM-domain gene required for male development in the medaka fish
    Masaru Matsuda
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Nature 417:559-63. 2002
  2. ncbi Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
  3. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010
  4. pmc Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 182:263-76. 2008
  5. doi Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 319:91-3. 2008
  6. pmc A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals
    Nandina Paria
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e21374. 2011
  7. pmc Genetic differentiation in South Amerindians is related to environmental and cultural diversity: evidence from the Y chromosome
    E Tarazona-Santos
    , Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Am J Hum Genet 68:1485-96. 2001
  8. ncbi The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective
    O Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 290:1155-9. 2000
  9. ncbi Oxidative stress, DNA damage and the Y chromosome
    R J Aitken
    School of Biological and Chemical Sciences, Centre for Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 23008, Australia
    Reproduction 122:497-506. 2001
  10. pmc The temporal dynamics of processes underlying Y chromosome degeneration
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Genetics 179:1513-25. 2008

Research Grants

Detail Information

Publications252 found, 100 shown here

  1. ncbi DMY is a Y-specific DM-domain gene required for male development in the medaka fish
    Masaru Matsuda
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Nature 417:559-63. 2002
    ..to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion analysis of the Y chromosome of a congenic XY female further shortened the region to 250 kb...
  2. ncbi Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
    ..These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1...
  3. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010
    The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over with the X chromosome...
  4. pmc Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 182:263-76. 2008
    ..Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI...
  5. doi Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 319:91-3. 2008
    The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila contrasts with data indicating that this chromosome has polymorphic phenotypic effects on sex ratio, temperature sensitivity, behavior, and fitness...
  6. pmc A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals
    Nandina Paria
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e21374. 2011
    Studies of the Y chromosome in primates, rodents and carnivores provide compelling evidence that the male specific region of Y (MSY) contains functional genes, many of which have specialized roles in spermatogenesis and male-fertility...
  7. pmc Genetic differentiation in South Amerindians is related to environmental and cultural diversity: evidence from the Y chromosome
    E Tarazona-Santos
    , Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Am J Hum Genet 68:1485-96. 2001
    ..This model is consistent with the linguistic and cultural diversity of South Amerindians, the environmental heterogeneity of the continent, and the available paleoecological data...
  8. ncbi The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective
    O Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 290:1155-9. 2000
    A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied...
  9. ncbi Oxidative stress, DNA damage and the Y chromosome
    R J Aitken
    School of Biological and Chemical Sciences, Centre for Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 23008, Australia
    Reproduction 122:497-506. 2001
    ..advances in understanding of male infertility have implicated two major causative factors, oxidative stress and Y chromosome deletions...
  10. pmc The temporal dynamics of processes underlying Y chromosome degeneration
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Genetics 179:1513-25. 2008
    ..Here I show that the relative importance of these processes is expected to vary over the course of Y chromosome evolution due to changes in the number of active genes...
  11. doi Sex-specific adaptation drives early sex chromosome evolution in Drosophila
    Qi Zhou
    Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Science 337:341-5. 2012
    ..We studied the sex chromosomes of Drosophila miranda, where a neo-Y chromosome originated only approximately 1 million years ago...
  12. doi Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa
    Filipe Pereira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Mol Biol Evol 26:2765-73. 2009
    ..We present the first study combining results from mitochondrial DNA (mtDNA) and Y chromosome loci for the genetic characterization of a domestic goat population...
  13. pmc Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation
    Silvana Paredes
    Department of Biology, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 7:e1001376. 2011
    ..Altogether, our results indicate that subtle changes to rDNA copy number between individuals may contribute to biologically relevant phenotypic variation...
  14. pmc Nonrandom gene loss from the Drosophila miranda neo-Y chromosome
    Vera B Kaiser
    Department of Integrative Biology, University of California Berkeley, USA
    Genome Biol Evol 3:1329-37. 2011
    A lack of recombination leads to the degeneration of an evolving Y chromosome. However, it is not known whether gene loss is largely a random process and primarily driven by the order in which mutations occur or whether certain categories ..
  15. pmc Dual origins of dairy cattle farming--evidence from a comprehensive survey of European Y-chromosomal variation
    Ceiridwen J Edwards
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e15922. 2011
    ....
  16. ncbi Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    ..The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between ..
  17. ncbi The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome
    M J Mitchell
    INSERM U406, Facult e de M edecine La Timone, 13385 Marseille, France
    Hum Mol Genet 7:429-34. 1998
    ..are thought to be descended from a homologous pair of autosomes: a testis-determining allele which defined the Y chromosome arose, recombination between the nascent X and Y chromosomes became restricted and the Y chromosome gradually ..
  18. doi Evidence for degeneration of the Y chromosome in the dioecious plant Silene latifolia
    Gabriel A B Marais
    Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, 69622 Villeurbanne Cedex, France
    Curr Biol 18:545-9. 2008
    ..There are clear signs of degeneration in the Drosophila miranda neoY chromosome (an autosome fused to the Y chromosome), with neoY genes showing faster protein evolution [3-6], accumulation of unpreferred codons [6], more ..
  19. ncbi An accumulation of tandem DNA repeats on the Y chromosome in Silene latifolia during early stages of sex chromosome evolution
    Roman Hobza
    Laboratory of Plant Developmental Genetics, Institute of Biophysics, Academy of Sciences of Czech Republic, Kralovopolska Street 135, Brno 612 65, Czech Republic
    Chromosoma 115:376-82. 2006
    Sex chromosomes in mammals are about 300 million years old and typically have a highly degenerated Y chromosome. The sex chromosomes in the dioecious plant Silene latifolia in contrast, represent an early stage of evolution in which ..
  20. ncbi The Y chromosome effect on blood pressure in two European populations
    Fadi J Charchar
    British Heart Foundation Blood Pressure Group, Department of Medicine, University of Glasgow, United Kingdom
    Hypertension 39:353-6. 2002
    ..pressure (BP) in males compared with females is well documented and is thought to be influenced in part by the Y chromosome. To examine whether there is an association between BP and a polymorphic HindIII biallelic marker in the ..
  21. pmc Frequent gene conversion events between the X and Y homologous chromosomal regions in primates
    Mineyo Iwase
    The Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies Sokendai, Shonan Village, Hayama, Kanagawa 240 0193, Japan
    BMC Evol Biol 10:225. 2010
    ..To examine the evolutionary mechanism for this low p-distance region, sequences of a corresponding region including KALX/Y from seven species of non-human primates were analyzed...
  22. doi Re-sequencing regions of the ovine Y chromosome in domestic and wild sheep reveals novel paternal haplotypes
    J R S Meadows
    CSIRO Livestock Industries, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Anim Genet 40:119-23. 2009
    The male-specific region of the ovine Y chromosome (MSY) remains poorly characterized, yet sequence variants from this region have the potential to reveal the wild progenitor of domestic sheep or examples of domestic and wild paternal ..
  23. ncbi Y chromosomes: born to be destroyed
    Sigrid Steinemann
    Institut für Molekulargenetik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Bioessays 27:1076-83. 2005
    ..They are more exposed to the decay process. (5) Gene dosage balance is re-established by the parallel evolution of dosage compensation mechanisms...
  24. doi Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)
    C K Hamilton
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Sex Dev 3:205-13. 2009
    Multi-copied gene families are prevalent in mammalian genomes, especially within the Y chromosome. Testis specific protein Y-encoded (TSPY) is present in variable copy number in many mammalian species...
  25. pmc Novel gene acquisition on carnivore Y chromosomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 2:e43. 2006
    Despite its importance in harboring genes critical for spermatogenesis and male-specific functions, the Y chromosome has been largely excluded as a priority in recent mammalian genome sequencing projects...
  26. pmc The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes
    E C Salido
    Howard Hughes Medical Institute, University of California School of Medicine, Harbor UCLA Medical Center, Torrance
    Am J Hum Genet 50:303-16. 1992
    ....
  27. pmc Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster
    Pan Pan Jiang
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 186:109-18. 2010
    The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species...
  28. pmc Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations
    F Marchetti
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 104:17725-9. 2007
    ....
  29. pmc The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting
    Keith A Maggert
    The Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genetics 162:1245-58. 2002
    ..We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila melanogaster and found that all but one location showed differential expression of one or both ..
  30. pmc The degeneration of Y chromosomes
    B Charlesworth
    Institute for Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
    Philos Trans R Soc Lond B Biol Sci 355:1563-72. 2000
    ..It is, however, currently unclear which of the various processes is most important; some directions for future work to help to resolve this question are discussed...
  31. ncbi A radiation hybrid map for the bovine Y Chromosome
    Wan Sheng Liu
    Department of Animal Science, College of Agricultural, Food, and Environmental Sciences, University of Minnesota, 305 Haecker Hall, 1364 Eckles Avenue, St Paul 55108, USA
    Mamm Genome 13:320-6. 2002
    Screening a bovine Y Chromosome-specific DNA library resulted in 34 new microsatellites, six of which mapped to the pseudoautosomal region (PAR), and 28 localized to the Y-specific region...
  32. ncbi Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal
    E M Eicher
    Science 217:535-7. 1982
  33. pmc Dog Y chromosomal DNA sequence: identification, sequencing and SNP discovery
    Christian Natanaelsson
    School of Biotechnology, KTH, Royal Institute of Technology, AlbaNova University Center, 10691 Stockholm, Sweden
    BMC Genet 7:45. 2006
    ..bp of non-repetitive dog Y-chromosome sequence deposited in GenBank, necessitating the identification of dog Y chromosome sequence and the search for polymorphisms therein...
  34. ncbi Four evolutionary strata on the human X chromosome
    B T Lahn
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 286:964-7. 1999
    ..The first event, which marked the beginnings of X-Y differentiation, occurred about 240 to 320 million years ago, shortly after divergence of the mammalian and avian lineages...
  35. pmc Y chromosome polymorphism is a strong determinant of male fitness in Drosophila melanogaster
    A K Chippindale
    Department of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 98:5677-82. 2001
    ....
  36. ncbi Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes
    Xuqi Chen
    Department of Physiological Science, University of California, Los Angeles, CA, USA
    Dev Neurobiol 68:265-73. 2008
    ..We also examined mice in which the testis-determining gene Sry is deleted from the Y chromosome but inserted onto an autosome as a transgene, producing XX and XY gonadal females and XX and XY gonadal males...
  37. ncbi Postmeiotic sex chromatin in the male germline of mice
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 16:660-7. 2006
    ..We conclude that chromosome-wide X silencing continues from meiosis to the end of spermiogenesis, and we discuss implications for proposed mechanisms of imprinted X-inactivation...
  38. pmc Cytogenetic analysis of a segment of the Y chromosome of Drosophila melanogaster
    R W Hardy
    Genetics 107:591-610. 1984
    Males carrying a large deficiency in the long arm of the Y chromosome known to delete the fertility gene kl-2 are sterile and exhibit a complex phenotype: (1) First metaphase chromosomes are irregular in outline and appear sticky; (2) ..
  39. ncbi Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain
    P Blanco
    Human Molecular Genetics Group, Division of Cellular and Molecular Pathology, University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, England, UK
    Mamm Genome 11:906-14. 2000
    ..The implications of Y-linked genes expressed predominantly in tissues and organs other than the testis are considered within the context of the concept of sexual selection...
  40. pmc Low conservation of gene content in the Drosophila Y chromosome
    Leonardo B Koerich
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944 970, Rio de Janeiro, Brazil
    Nature 456:949-51. 2008
    ..melanogaster Y chromosome is much younger...
  41. doi Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome
    Alison J Pearks Wilkerson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Genomics 92:329-38. 2008
    ..As a consequence of random decay and chromosome rearrangements over evolutionary time, Y chromosome gene repertoires differ between eutherian lineages...
  42. ncbi Fixed nucleotide differences on the Y chromosome indicate clear divergence between Equus przewalskii and Equus caballus
    B Wallner
    Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Veterinärplatz, Wien, Austria
    Anim Genet 34:453-6. 2003
    ..Here we report sequence variation from five newly identified Y chromosome regions of the horse...
  43. ncbi Expression analysis of Y chromosome genes in human prostate cancer
    V K Dasari
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    J Urol 165:1335-41. 2001
    PURPOSE: We hypothesized that alterations in Y chromosome gene expression may be associated with prostate cancer. To test this hypothesis we analyzed the expression of 19 Y chromosome genes in benign and malignant prostate tissue...
  44. doi The cutthroat trout Y chromosome is conserved with that of rainbow trout
    M A Alfaqih
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
    Cytogenet Genome Res 121:255-9. 2008
    ..marker Omm1665, which maps close to the sex locus of Yellowstone cutthroat trout, was used to identify the Y chromosome of cutthroat trout in the hybrid...
  45. doi Chromosome-wide gene silencing initiates Y degeneration in Drosophila
    Qi Zhou
    Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Curr Biol 22:522-5. 2012
    ..Y-linked genes at the amino acid level? Here, we study patterns of gene expression of the recently formed neo-Y chromosome of Drosophila albomicans, which displays few signs of degeneration of protein-coding genes...
  46. doi Discovery of lost diversity of paternal horse lineages using ancient DNA
    Sebastian Lippold
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nat Commun 2:450. 2011
    ..within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of ..
  47. ncbi Zfy gene expression patterns are not compatible with a primary role in mouse sex determination
    P Koopman
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
    Nature 342:940-2. 1989
    The Y chromosome determines maleness in mammals. A Y chromosome-linked gene diverts the indifferent embryonic gonad from the default ovarian pathway in favour of testis differentiation, initiating male development...
  48. ncbi PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes
    N D Wilson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Cytogenet Genome Res 114:137-9. 2006
    ..This paper provides for the first time direct evidence for the absence of the PCDH11 genefrom the Y chromosome of chimpanzee (Pan troglodytes) as well as gorilla (Gorilla gorilla)...
  49. ncbi Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome
    G Mardon
    Whitehead Institute, Nine Cambridge Center, MA 02142
    Science 243:78-80. 1989
    The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF...
  50. pmc Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila
    Jun Zhou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:9941-6. 2012
    Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked genes...
  51. doi A large palindrome with interchromosomal gene duplications in the pericentromeric region of the D. melanogaster Y chromosome
    Maria Mendez-Lago
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Mol Biol Evol 28:1967-71. 2011
    The non-recombining Y chromosome is expected to degenerate over evolutionary time, however, gene gain is a common feature of Y chromosomes of mammals and Drosophila...
  52. ncbi The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues
    C M Nagamine
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 4:63-74. 1990
    ..However, because the Zfy genes are apparently also expressed during spermatogenesis and in fetal organs other than testes, they may serve additional functions besides their postulated role in testis determination...
  53. pmc Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution
    Veronica J Murtagh
    Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
    Genome Res 22:498-507. 2012
    ..Thus, the small marsupial Y chromosome is surprisingly rich in ancient genes that are retained in at least Australian marsupials and evolved from ..
  54. ncbi A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
    J Gubbay
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 346:245-50. 1990
    A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis ..
  55. ncbi Patchy fur (Paf), a semidominant X-linked gene associated with a high level of X-Y nondisjunction in male mice
    P W Lane
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Hered 81:43-50. 1990
    ..The effect occurs only in male carriers and thus must extend into the proximal end of the XY pairing region...
  56. ncbi Inherited sex reversal in mice: identification of a new primary sex-determining gene
    E M Eicher
    J Exp Zool 228:297-304. 1983
    ..at a locus involved in gonad determination and development as well as at the testis-determining locus on the Y chromosome (Tdy). This newly identified gene is named testis-determining, autosomal-1 (tda-1)...
  57. ncbi Chromosome mapping and expression of a putative testis-determining gene in mouse
    C M Nagamine
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Science 243:80-3. 1989
    ..Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination...
  58. pmc A large expansion of the HSFY gene family in cattle shows dispersion across Yq and testis-specific expression
    Christine K Hamilton
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 6:e17790. 2011
    ..is a member of the heat shock transcriptional factor (HSF) family that is found in multiple copies on the Y chromosome and conserved in a number of species...
  59. doi Integrating Y-chromosome, mitochondrial, and autosomal data to analyze the origin of pig breeds
    O Ramirez
    Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Mol Biol Evol 26:2061-72. 2009
    ..The existence of Spanish and Portuguese commercial routes linking Asia with America might have favored the introduction of Far Eastern breeds into this continent...
  60. ncbi Development of Y chromosome intraspecific polymorphic markers in the Felidae
    Shu Jin Luo
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Hered 98:400-13. 2007
    b>Y chromosome haplotyping based on microsatellites and single nucleotide polymorphisms (SNPs) has proved to be a powerful tool for population genetic studies of humans...
  61. pmc Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila
    Timothy B Sackton
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:17046-51. 2011
    The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes...
  62. ncbi Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation
    Erica L Herzog
    Yale University School of Medicine, Internal Medicine Pulmonary and Critical Care Division, 333 Cedar St, TAC 441 S, New Haven CT 06511, USA
    FASEB J 21:2592-601. 2007
    ..In male recipients of female BM, 65% of Sp-C + cells contained the Y chromosome, indicating their origin from fusion...
  63. ncbi The presence of X- and Y-chromosomes in oocytes leads to impairment in the progression of the second meiotic division
    M Villemure
    Urology Research Laboratory, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Dev Biol 301:1-13. 2007
    ..Similar results were obtained after fertilization. We conclude that the XY chromosomal composition in oocyte leads to impairment in the progression of the second meiotic division...
  64. ncbi Significant population variation in adult male height associated with the Y chromosome and the aromatase gene
    J A Ellis
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Clin Endocrinol Metab 86:4147-50. 2001
    ..stature have been identified, including mutations in the gene encoding aromatase (CYP19) and regions on the Y chromosome. However, the possible role of these loci in the genetic control of normal adult height is unknown...
  65. ncbi Screening for deletions in interval D16-22 of the Y chromosome in azoospermic and oligozoospermic Japanese men
    H Kato
    Advanced Fertility Center, Huchu Hospital, Osaka, Japan
    J Hum Genet 46:110-4. 2001
    The genetic basis of infertility remains unclear in a majority of infertile men. In this study, the Y chromosome long arm involving the DAZ (deleted in azoospermia) gene was screened in order to evaluate the occurrence of microdeletion in ..
  66. pmc Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster
    Debashish U Menon
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Genetics 183:811-20. 2009
    ..Genetic tests indicate that the effect on male survival depends upon the presence and source of the Y chromosome, revealing a germ line imprint that influences dosage compensation...
  67. doi The horse pseudoautosomal region (PAR): characterization and comparison with the human, chimp and mouse PARs
    T Raudsepp
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Cytogenet Genome Res 121:102-9. 2008
    ..Although striking differences like those observed between human and mouse may be rare, variations similar to those seen between horse and human may be prevalent among mammals...
  68. doi Y-specific microsatellites reveal an African subfamily in taurine (Bos taurus) cattle
    L Pérez-Pardal
    Área de Genética y Reproducción Animal, SERIDA, Camino de los Claveles 604 33203 Gijón, Spain
    Anim Genet 41:232-41. 2010
    ..However, Y-specific microsatellites increased analytical resolution and allowed at least two different Y2-haplotypic subfamilies to be distinguished, one of them restricted to the African continent...
  69. ncbi Organization and expression of rat Tspy
    F Dechend
    Institut fur Humangenetik, Medizinische Hochschule, Hannover, Germany
    Cytogenet Cell Genet 83:270-4. 1998
    ....
  70. pmc A view of modern human origins from Y chromosome microsatellite variation
    M Seielstad
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115 6096 USA
    Genome Res 9:558-67. 1999
    ..We analyze variation at 10 Y chromosome microsatellite loci that were typed in 506 males representing 49 populations and every inhabited continent and ..
  71. ncbi Sex chromosomes of basal placental mammals
    Paul D Waters
    Evolutionary Genomics Group, Department of Botany and Zoology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Chromosoma 116:511-8. 2007
    ....
  72. ncbi Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosome
    R J Van Golde
    Departments of Obstetrics and Gynaecology, Human Genetics and Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Hum Reprod 16:289-92. 2001
    Microdeletions of the azoospermia factor (AZF) region of the Y chromosome occur in between 1 and 29% of oligozoospermic and azoospermic men, and most deletions are found in the AZFc region...
  73. ncbi Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene
    R Reijo
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nat Genet 10:383-93. 1995
    We have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with azoospermia (no sperm in semen). No Y deletions were detected in their male relatives or in 90 other fertile males...
  74. doi Unequal rates of Y chromosome gene divergence during speciation of the family Ursidae
    Shigeki Nakagome
    Division of Biological Science, Graduate School of Science, Hokkaido University, Sapporo, Japan
    Mol Biol Evol 25:1344-56. 2008
    ..variation among genes with different modes of inheritance: matrilineal mitochondrial DNA (mtDNA), patrilineal Y chromosome, biparentally inherited autosomes, and the X chromosome...
  75. ncbi Geographic origin of the Y chromosomes in "old" inbred strains of mice
    P K Tucker
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 3:254-61. 1992
    ..musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains...
  76. pmc Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm
    D J Elliott
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, Scotland
    Proc Natl Acad Sci U S A 94:3848-53. 1997
    The association of abnormal spermatogenesis in men with Y chromosome deletions suggests that genes important for spermatogenesis have been removed from these individuals...
  77. pmc Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice
    Karen M Spach
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 182:1789-93. 2009
    ..To determine whether the Y chromosome contributes to this sexual dimorphism, EAE was induced in consomic SJL/J mice carrying a B10...
  78. pmc Origin and evolution of Y chromosomes: Drosophila tales
    A Bernardo Carvalho
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Trends Genet 25:270-7. 2009
    ..Surprisingly, the majority of Drosophila Y-linked genes are recent acquisitions from autosomes and Y chromosome gene gains are more frequent than gene losses...
  79. ncbi Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse
    S Mazeyrat
    INSERM U406, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Hum Mol Genet 7:557-62. 1998
    ..Y chromosomes generally do not recombine along most of their length, and thus Y chromosome genes, despite having been selectively maintained for their function, could be lost from the genome...
  80. pmc Muller's ratchet and the degeneration of Y chromosomes: a simulation study
    Jan Engelstädter
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 180:957-67. 2008
    ..On the other hand, a lower mutation rate in females than in males, background selection, and the emergence of dosage compensation are expected to accelerate the process...
  81. doi Two novel mouse genes mapped to chromosome Yp are expressed specifically in spermatids
    Lydia Ferguson
    Mammalian Molecular Genetics Group, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Mamm Genome 20:193-206. 2009
    The male-specific region of the Y chromosome is evolutionarily predisposed to accumulate genes important for spermatogenesis...
  82. ncbi Assignment of SRY, ANT3, and CSF2RA to the bovine Y chromosome by FISH and RH mapping
    Wan Sheng Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology, and Natural Resources, University of Nevada, Reno, Nevada 89557, USA
    Anim Biotechnol 15:103-9. 2004
    Three genes, SRY, ANT3, and CSF2RA, were mapped to the bovine Y chromosome (BTAY) by fluorescence in situ hybridization (FISH) and/or radiation hybrid (RH) mapping...
  83. pmc Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes
    Anne Sophie Van Laere
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
    Genome Res 18:1884-95. 2008
    ..that it maps to the 5' end of the GPR143 gene, which has concomitantly lost upstream noncoding exons on the Y chromosome. We show that the bovine PAB was created approximately 20...
  84. doi Governing sex determination in fish: regulatory putsches and ephemeral dictators
    J N Volff
    Department of Physiological Chemistry I, University of Wurzburg, Wurzburg, Germany
    Sex Dev 1:85-99. 2007
    ..has been formed through duplication of the autosomal gene dmrt1 onto another autosome, thus generating a new Y chromosome. Dmrt1bY emerged about 10 million years ago and is restricted to several Oryzias species, indicating that the Y ..
  85. doi An evolutionary witness: the frog rana rugosa underwent change of heterogametic sex from XY male to ZW female
    I Miura
    Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Hiroshima, Japan
    Sex Dev 1:323-31. 2007
    ..Change of the heterogametic sex will also be discussed, relating data from frogs (Rana) and other animals to the replacement of a master sex-determining gene in the course of speciation...
  86. ncbi Y chromosome conserved anchored tagged sequences (YCATS) for the analysis of mammalian male-specific DNA
    Linda Hellborg
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Mol Ecol 12:283-91. 2003
    b>Y chromosome haplotyping based on microsatellites or single nucleotide polymorphisms has recently proven to be a powerful approach for evolutionary studies of human populations, and also holds great promise for the studies of wild species...
  87. ncbi X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse
    John R McCarrey
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Genesis 34:257-66. 2002
    ....
  88. doi Evolution of X-degenerate Y chromosome genes in greater apes: conservation of gene content in human and gorilla, but not chimpanzee
    Hiroki Goto
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Mol Evol 68:134-44. 2009
    Compared with the X chromosome, the mammalian Y chromosome is considerably diminished in size and has lost most of its ancestral genes during evolution...
  89. pmc The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination
    A Pask
    Department of Genetics and Evolution, La Trobe University, Melbourne 3083, Australia
    Proc Natl Acad Sci U S A 97:13198-202. 2000
    ..There is no evidence for a Y-borne ATRX homologue in mouse or human, implying that this gene has been lost in eutherians and its role supplanted by the evolution of SRY from SOX3 as the dominant determiner of male differentiation...
  90. ncbi Endothelial cell chimerism after renal transplantation and vascular rejection
    E L Lagaaij
    Department of Pathology, Leiden University Medical Centre, The Netherlands
    Lancet 357:33-7. 2001
    ..The endothelium in the blood vessels is thought to be the major target for graft rejection. Endothelial cells of a transplanted organ are believed to remain of donor origin after transplantation. We aimed to verify this concept...
  91. ncbi A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
    A H Sinclair
    Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
    Nature 346:240-4. 1990
    A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene...
  92. ncbi Differences in recombination frequencies during female and male meioses of the sex chromosomes of the medaka, Oryzias latipes
    M Kondo
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genet Res 78:23-30. 2001
    ..curvinotus, a species related to the medaka. These markers could be used for genotyping the sex chromosomes in the medaka and other species, and could be used in other studies on sex chromosomes...
  93. doi Y chromosome haplotype analysis in Portuguese cattle breeds using SNPs and STRs
    Catarina Ginja
    Instituto Superior de Agronomia, Tapada da Ajuda, Lisboa, Portugal
    J Hered 100:148-57. 2009
    ..indicus) were tested for 5 single nucleotide polymorphisms, 1 "indel," and 7 microsatellites specific to the Y chromosome. The 13 Y-haplotypes defined included 3 previously described patrilines (Y1, Y2, and Y3) and 10 new haplotypes ..
  94. pmc Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markers
    E Hagelberg
    Department of Genetics, University of Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 354:141-52. 1999
    ..Our results show that the demographic expansion of the Austronesians has left a genetic footprint. However, there is no simple correlation between languages and genes in the Pacific...
  95. ncbi The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes
    N Levy
    INSERM U491, Génétique Médicale et Développement, Faculte de Medecine de la Timone, Marseille, France
    Mamm Genome 11:164-8. 2000
  96. ncbi Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal
    B Capel
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nat Genet 5:301-7. 1993
    An approach designed to map and generate mutations in the region of the short arm of the mouse Y chromosome, known to be involved in sex determination and spermatogenesis, is described...
  97. pmc Highly efficient sex chromosome interchanges produced by I-CreI expression in Drosophila
    Keith A Maggert
    Department of Biology, University of Utah, Salt Lake City, Utah 84112
    Genetics 171:1103-14. 2005
    ..This method has advantages over the traditional use of X rays for generating X-Y interchanges because it is very frequent and it generates predictable products...
  98. pmc A 7-bp insertion in the 3' untranslated region suggests the duplication and concerted evolution of the rabbit SRY gene
    Armando Geraldes
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Campus Agrário de Vairão, 4485 661 Vairão, e Departamento de Zoologia e Antropologia, Faculdade de Ciencias da Universidade do Porto, 4099 002 Porto, Portugal
    Genet Sel Evol 38:313-20. 2006
    ..In addition, the remarkable observation of haplotypes exhibiting 0, 1 and 2 7-bp inserts in essentially all algirus populations suggests that the rabbit SRY gene is duplicated and evolving under concerted evolution...
  99. ncbi A probe generated by chromosome microdissection, useful for analyzing Y chromosome evolution in Old World monkeys
    Takahiro Taguchi
    Department of Anatomy, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Chromosome Res 11:147-52. 2003
    We isolated a DNA probe, designated MMDYZ1, using a chromosome microdissection technique from the Y chromosome of the Rhesus monkey...
  100. pmc Non-invasive genetic monitoring of wild central chimpanzees
    Mimi Arandjelovic
    Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 6:e14761. 2011
    ..Genotyping non-invasively collected faecal samples is an effective way of evaluating a species' population size without disruption, and can also reveal details concerning population structure...
  101. ncbi Transposition of RhoA to the murine Y chromosome
    H L Boettger-Tong
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 49:180-7. 1998
    In an effort to produce a more complete transcription map of the short (approximately 5 Mb) arm of the mouse Y chromosome, we have initiated exon trapping from Yp-derived YACs...

Research Grants80

  1. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2010
    ..The novelty emerges from our recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many ..
  2. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..effect on disease outcomes and immune measures in Aims 1 and 2 is attributable to a gene unique to the Y chromosome versus the dosage of X genes...
  3. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2010
    ..effect on disease outcomes and immune measures in Aims 1 and 2 is attributable to a gene unique to the Y chromosome versus the dosage of X genes...
  4. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2010
    ....
  5. Microarray Analysis of H-Y Antibodies in Human Transplantation
    David Miklos; Fiscal Year: 2007
    ..Female donor H-Y reactivity will be correlated with male recipient clinical outcomes, and male recipient H-Y antibody epitope specificity thereby testing an H-Y B cell adoptive transfer hypothesis. ..
  6. MOUSE X-CHROMOSOME INACTIVATION
    Christine Disteche; Fiscal Year: 2003
    ..Evolution of the mammalian sex chromosomes is characterized by degeneration of the Y chromosome, once sex was determined by a gene on the Y chromosome and recombination was inhibited...
  7. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    Philippe Grandjean; Fiscal Year: 2007
    ..These will include measures of semen quality, ratio of X/Y chromosome-bearing sperm, chromatin stability of the sperm, sex ratio of births, and waiting time to pregnancy...
  8. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..These will include measures of semen quality, ratio of X/Y chromosome-bearing sperm, chromatin stability of the sperm, sex ratio of births, and waiting time to pregnancy...
  9. Genomics of Pediatric Headache Disorders
    Andrew Hershey; Fiscal Year: 2006
    ..The results of this study should help in beginning to develop a molecular genomic approach for the diagnosis and treatment of different headache disorders. ..
  10. SPECIES BOUNDARIES IN THE ANOPHELES GAMBIAE COMPLEX
    Nora Besansky; Fiscal Year: 2003
    ..gambia complex. The Y chromosome provides a powerful tool to attack questions at the population level and above, not only because it is ..
  11. Molecular Evolution of Drosophila Y Chromosome
    ANDREW G contact CLARK; Fiscal Year: 2010
    Because the Y chromosome is present in just one copy and only in males, it faces a diminished capacity to purge deleterious mutations...
  12. Male Reproductive Effects from Exposure to Boron
    Wendie Robbins; Fiscal Year: 2005
    ..toxicity on male reproduction: total sperm count, sperm density, viability, motility, morphology, and sperm X:Y chromosome ratios sperm chromatin integrity measured by sperm chromatin structure assay (SCSA), COMET, TUNEL, protamine 1 (..
  13. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2007
    ..b>Y chromosome. To confirm the real-time PCR data engrafted MSCs will be visualized in brain sections by immunofluorescent ..
  14. Validating Sexual Behavior by Y-chromosome PCR
    Jonathan Zenilman; Fiscal Year: 2005
    ..Since Yc sampling requires only a vaginal swab, and is stable under field conditions, this test promises to be a practical and easily used biomarker for sexual behavior research. ..