y chromosome

Summary

Summary: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.

Top Publications

  1. ncbi DMY is a Y-specific DM-domain gene required for male development in the medaka fish
    Masaru Matsuda
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Nature 417:559-63. 2002
  2. ncbi Four evolutionary strata on the human X chromosome
    B T Lahn
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 286:964-7. 1999
  3. ncbi Male development of chromosomally female mice transgenic for Sry
    P Koopman
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 351:117-21. 1991
  4. pmc The degeneration of Y chromosomes
    B Charlesworth
    Institute for Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
    Philos Trans R Soc Lond B Biol Sci 355:1563-72. 2000
  5. ncbi A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
    A H Sinclair
    Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
    Nature 346:240-4. 1990
  6. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010
  7. ncbi Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
  8. ncbi Population growth of human Y chromosomes: a study of Y chromosome microsatellites
    J K Pritchard
    Department of Biological Sciences, Stanford University
    Mol Biol Evol 16:1791-8. 1999
  9. ncbi Y chromosome sequence variation and the history of human populations
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California
    Nat Genet 26:358-61. 2000
  10. ncbi Functional coherence of the human Y chromosome
    B T Lahn
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 278:675-80. 1997

Detail Information

Publications290 found, 100 shown here

  1. ncbi DMY is a Y-specific DM-domain gene required for male development in the medaka fish
    Masaru Matsuda
    Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Nature 417:559-63. 2002
    ..to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion analysis of the Y chromosome of a congenic XY female further shortened the region to 250 kb...
  2. ncbi Four evolutionary strata on the human X chromosome
    B T Lahn
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 286:964-7. 1999
    ..The first event, which marked the beginnings of X-Y differentiation, occurred about 240 to 320 million years ago, shortly after divergence of the mammalian and avian lineages...
  3. ncbi Male development of chromosomally female mice transgenic for Sry
    P Koopman
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 351:117-21. 1991
    The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located ..
  4. pmc The degeneration of Y chromosomes
    B Charlesworth
    Institute for Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
    Philos Trans R Soc Lond B Biol Sci 355:1563-72. 2000
    ..It is, however, currently unclear which of the various processes is most important; some directions for future work to help to resolve this question are discussed...
  5. ncbi A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
    A H Sinclair
    Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
    Nature 346:240-4. 1990
    A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene...
  6. pmc Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 463:536-9. 2010
    The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over with the X chromosome...
  7. ncbi Silencing of unsynapsed meiotic chromosomes in the mouse
    James M A Turner
    Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Genet 37:41-7. 2005
    ..These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1...
  8. ncbi Population growth of human Y chromosomes: a study of Y chromosome microsatellites
    J K Pritchard
    Department of Biological Sciences, Stanford University
    Mol Biol Evol 16:1791-8. 1999
    We use variation at a set of eight human Y chromosome microsatellite loci to investigate the demographic history of the Y chromosome...
  9. ncbi Y chromosome sequence variation and the history of human populations
    P A Underhill
    Department of Genetics, Stanford University, Stanford, California
    Nat Genet 26:358-61. 2000
    Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population ..
  10. ncbi Functional coherence of the human Y chromosome
    B T Lahn
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 278:675-80. 1997
    A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full-length complementary DNA sequences...
  11. pmc A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes
    Indrajit Nanda
    Institute for Human Genetics, Biocenter, University of Wurzburg, D 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 99:11778-83. 2002
    ..We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb...
  12. ncbi A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
    J Gubbay
    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 346:245-50. 1990
    A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis ..
  13. ncbi Postmeiotic sex chromatin in the male germline of mice
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, 02114, USA
    Curr Biol 16:660-7. 2006
    ..We conclude that chromosome-wide X silencing continues from meiosis to the end of spermiogenesis, and we discuss implications for proposed mechanisms of imprinted X-inactivation...
  14. ncbi Governing sex determination in fish: regulatory putsches and ephemeral dictators
    J N Volff
    Department of Physiological Chemistry I, University of Wurzburg, Wurzburg, Germany
    Sex Dev 1:85-99. 2007
    ..has been formed through duplication of the autosomal gene dmrt1 onto another autosome, thus generating a new Y chromosome. Dmrt1bY emerged about 10 million years ago and is restricted to several Oryzias species, indicating that the Y ..
  15. pmc Nonrandom gene loss from the Drosophila miranda neo-Y chromosome
    Vera B Kaiser
    Department of Integrative Biology, University of California Berkeley, USA
    Genome Biol Evol 3:1329-37. 2011
    A lack of recombination leads to the degeneration of an evolving Y chromosome. However, it is not known whether gene loss is largely a random process and primarily driven by the order in which mutations occur or whether certain categories ..
  16. pmc TALEN-mediated editing of the mouse Y chromosome
    Haoyi Wang
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Biotechnol 31:530-2. 2013
    The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations...
  17. pmc Origin and evolution of Y chromosomes: Drosophila tales
    A Bernardo Carvalho
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Trends Genet 25:270-7. 2009
    ..Surprisingly, the majority of Drosophila Y-linked genes are recent acquisitions from autosomes and Y chromosome gene gains are more frequent than gene losses...
  18. pmc A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse
    Julie Cocquet
    INSERM, U1016, Institut Cochin, Paris, France
    PLoS Genet 8:e1002900. 2012
    ..It also provides a biological basis for the concept that intragenomic conflict is an important evolutionary force which impacts on gene expression, genome structure, and speciation...
  19. pmc A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals
    Nandina Paria
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 6:e21374. 2011
    Studies of the Y chromosome in primates, rodents and carnivores provide compelling evidence that the male specific region of Y (MSY) contains functional genes, many of which have specialized roles in spermatogenesis and male-fertility...
  20. pmc Genetic differentiation in South Amerindians is related to environmental and cultural diversity: evidence from the Y chromosome
    E Tarazona-Santos
    , Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Am J Hum Genet 68:1485-96. 2001
    ..This model is consistent with the linguistic and cultural diversity of South Amerindians, the environmental heterogeneity of the continent, and the available paleoecological data...
  21. ncbi The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome
    Catherine L Peichel
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Curr Biol 14:1416-24. 2004
    ..Here, we investigate the genetic and chromosomal mechanisms that underlie sex determination in the threespine stickleback (Gasterosteus aculeatus)...
  22. ncbi Oxidative stress, DNA damage and the Y chromosome
    R J Aitken
    School of Biological and Chemical Sciences, Centre for Life Sciences, University of Newcastle, University Drive, Callaghan, NSW 23008, Australia
    Reproduction 122:497-506. 2001
    ..advances in understanding of male infertility have implicated two major causative factors, oxidative stress and Y chromosome deletions...
  23. pmc Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
    Shantha K Mahadevaiah
    Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
    J Cell Biol 182:263-76. 2008
    ..Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI...
  24. pmc Identification of five new genes on the Y chromosome of Drosophila melanogaster
    A B Carvalho
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Caixa Postal 68011 CEP 21944 970, Rio de Janeiro, Brazil
    Proc Natl Acad Sci U S A 98:13225-30. 2001
    The heterochromatic state of the Drosophila Y chromosome has made the cloning and identification of Y-linked genes a challenging process...
  25. ncbi The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective
    O Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 290:1155-9. 2000
    A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied...
  26. ncbi An accumulation of tandem DNA repeats on the Y chromosome in Silene latifolia during early stages of sex chromosome evolution
    Roman Hobza
    Laboratory of Plant Developmental Genetics, Institute of Biophysics, Academy of Sciences of Czech Republic, Kralovopolska Street 135, Brno 612 65, Czech Republic
    Chromosoma 115:376-82. 2006
    Sex chromosomes in mammals are about 300 million years old and typically have a highly degenerated Y chromosome. The sex chromosomes in the dioecious plant Silene latifolia in contrast, represent an early stage of evolution in which ..
  27. ncbi Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 319:91-3. 2008
    The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila contrasts with data indicating that this chromosome has polymorphic phenotypic effects on sex ratio, temperature sensitivity, behavior, and fitness...
  28. pmc Dynamics of a human interparalog gene conversion hotspot
    Elena Bosch
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Genome Res 14:835-44. 2004
    ..Here we exploit the haploid nature of the Y chromosome, which obviates complicating interallelic processes, together with its known phylogeny, to understand the ..
  29. ncbi Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal
    E M Eicher
    Science 217:535-7. 1982
  30. pmc Fine mapping of satellite DNA sequences along the Y chromosome of Drosophila melanogaster: relationships between satellite sequences and fertility factors
    S Bonaccorsi
    Centro di Genetica Evoluzionistica del CNR, Universita di Roma La Sapienza, Italy
    Genetics 129:177-89. 1991
    The entirely heterochromatic Y chromosome of Drosophila melanogaster contains a series of simple sequence satellite DNAs which together account for about 80% of its length...
  31. pmc The temporal dynamics of processes underlying Y chromosome degeneration
    Doris Bachtrog
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Genetics 179:1513-25. 2008
    ..Here I show that the relative importance of these processes is expected to vary over the course of Y chromosome evolution due to changes in the number of active genes...
  32. ncbi Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    D S Krause
    Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 105:369-77. 2001
    ..This finding may contribute to clinical treatment of genetic disease or tissue repair...
  33. ncbi Sex identification in mammals with polymerase chain reaction and its use to examine sex effects on diameter of day-10 or -11 pig embryos
    D Pomp
    Department of Animal Science, Oklahoma State University, Stillwater 74078, USA
    J Anim Sci 73:1408-15. 1995
    ....
  34. ncbi Sexing and multiple genotype analysis from a single cell of bovine embryo
    P Chrenek
    INRA, Biology of Development, Jouy en Josas, France
    Theriogenology 55:1071-81. 2001
    ..05), as was seen by obtaining a similar percentage of embryos developing further into the blastocyst stage in the group subjected to biopsy (44/75, 59%) and in the control group of embryos (30/50, 60%)...
  35. pmc Y chromosome polymorphism is a strong determinant of male fitness in Drosophila melanogaster
    A K Chippindale
    Department of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 98:5677-82. 2001
    ....
  36. pmc Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila
    Timothy B Sackton
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 108:17046-51. 2011
    The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes...
  37. ncbi Lack of a fusion requirement for development of bone marrow-derived epithelia
    Robert G Harris
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 305:90-3. 2004
    ..We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion...
  38. ncbi Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation
    Erica L Herzog
    Yale University School of Medicine, Internal Medicine Pulmonary and Critical Care Division, 333 Cedar St, TAC 441 S, New Haven CT 06511, USA
    FASEB J 21:2592-601. 2007
    ..In male recipients of female BM, 65% of Sp-C + cells contained the Y chromosome, indicating their origin from fusion...
  39. ncbi Sex chromosome mosaicism in males carrying Y chromosome long arm deletions
    J P Siffroi
    Service d Histologie, Biologie de la Reproduction et Cytogénétique et CECOS, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Hum Reprod 15:2559-62. 2000
    Microdeletions of the long arm of the Y chromosome (Yq) are a common cause of male infertility...
  40. pmc Six novel Y chromosome genes in Anopheles mosquitoes discovered by independently sequencing males and females
    Andrew Brantley Hall
    Department of Biochemistry, Virginia Tech, Blacksburg, VA, USA
    BMC Genomics 14:273. 2013
    ..However, Y genes are rarely characterized outside a few model species due to the arduous nature of studying the repeat-rich Y...
  41. ncbi Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist
    James M A Turner
    Division of Developmental Genetics, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Cell Sci 115:4097-105. 2002
    ..is inactivated early in embryogenesis, while in the male, the X chromosome is inactivated together with the Y chromosome in spermatogenic cells shortly before or during early meiotic prophase...
  42. ncbi A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes
    P Blanco
    Human Molecular Genetics Group, Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Genomics 74:1-11. 2001
    ..The close proximity of this gene to translocation breakpoints associated with premature ovarian failure makes it a potential candidate for this condition...
  43. ncbi The presence of X- and Y-chromosomes in oocytes leads to impairment in the progression of the second meiotic division
    M Villemure
    Urology Research Laboratory, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Dev Biol 301:1-13. 2007
    ..Similar results were obtained after fertilization. We conclude that the XY chromosomal composition in oocyte leads to impairment in the progression of the second meiotic division...
  44. ncbi Male sterility at extreme temperatures: a significant but neglected phenomenon for understanding Drosophila climatic adaptations
    J R David
    CNRS, Laboratoire Populations, Genetique et Evolution, Gif sur Yvette Cedex, France
    J Evol Biol 18:838-46. 2005
    ..genetic analysis revealed that about 50% of the difference observed between natural populations was due to the Y chromosome. Natural populations have not reached a selection limit, however: thermal tolerance was still increased by ..
  45. ncbi Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome
    D L Ely
    Department of Biology, University of Akron, Ohio 44325
    Hypertension 16:277-81. 1990
    ..01). There was no significant difference between the blood pressure of the F1 females, further supporting Y chromosome linkage and not parental imprinting...
  46. ncbi Reduced adaptation of a non-recombining neo-Y chromosome
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Nature 416:323-6. 2002
    ..Suppression of recombination between the ancestral sex chromosomes led to the genetic degeneration of the Y chromosome. In response, the X chromosome may become dosage-compensated...
  47. ncbi Plant sex determination and sex chromosomes
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Heredity (Edinb) 88:94-101. 2002
    ..Theories for Y chromosome degeneration are reviewed in the light of recent results from genes on plant sex chromosomes.
  48. ncbi Heat induced male sterility in Drosophila melanogaster: adaptive genetic variations among geographic populations and role of the Y chromosome
    Céline Rohmer
    CNRS UPR 9034, Avenue de la Terrasse, Laboratoire Populations, Genetique et Evolution, F 91 198 Gif sur Yvette Cedex, France
    J Exp Biol 207:2735-43. 2004
    ..Crosses between a temperate and a tropical strain (F1, F2 and successive backcrosses) revealed that the Y chromosome was responsible for much of the geographic variation...
  49. ncbi Discovery of lost diversity of paternal horse lineages using ancient DNA
    Sebastian Lippold
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Nat Commun 2:450. 2011
    ..within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of ..
  50. ncbi Genetic dissection of testis weight in mice: quantitative trait locus analysis using F(2) intercrosses between strains with extreme testis weight, and association study using Y-consomic strains
    Jun ichi Suto
    National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Mamm Genome 22:648-60. 2011
    ..Autosomes and the X chromosome were searched using traditional quantitative trait locus (QTL) scans, and the Y chromosome was searched by association studies of Y-consomic strains...
  51. ncbi Evidence for degeneration of the Y chromosome in the dioecious plant Silene latifolia
    Gabriel A B Marais
    Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, 69622 Villeurbanne Cedex, France
    Curr Biol 18:545-9. 2008
    ..There are clear signs of degeneration in the Drosophila miranda neoY chromosome (an autosome fused to the Y chromosome), with neoY genes showing faster protein evolution [3-6], accumulation of unpreferred codons [6], more ..
  52. pmc Dual origins of dairy cattle farming--evidence from a comprehensive survey of European Y-chromosomal variation
    Ceiridwen J Edwards
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 6:e15922. 2011
    ....
  53. ncbi Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa
    Filipe Pereira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Mol Biol Evol 26:2765-73. 2009
    ..We present the first study combining results from mitochondrial DNA (mtDNA) and Y chromosome loci for the genetic characterization of a domestic goat population...
  54. ncbi Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    ..The Y chromosome can be used to detect migrated undifferentiated cells expressing stem-cell antigens and to discriminate between ..
  55. pmc Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation
    Silvana Paredes
    Department of Biology, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 7:e1001376. 2011
    ..Altogether, our results indicate that subtle changes to rDNA copy number between individuals may contribute to biologically relevant phenotypic variation...
  56. pmc Sex-specific adaptation drives early sex chromosome evolution in Drosophila
    Qi Zhou
    Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Science 337:341-5. 2012
    ..We studied the sex chromosomes of Drosophila miranda, where a neo-Y chromosome originated only approximately 1 million years ago...
  57. pmc Frequent gene conversion events between the X and Y homologous chromosomal regions in primates
    Mineyo Iwase
    The Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies Sokendai, Shonan Village, Hayama, Kanagawa 240 0193, Japan
    BMC Evol Biol 10:225. 2010
    ..To examine the evolutionary mechanism for this low p-distance region, sequences of a corresponding region including KALX/Y from seven species of non-human primates were analyzed...
  58. ncbi The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome
    M J Mitchell
    INSERM U406, Facult e de M edecine La Timone, 13385 Marseille, France
    Hum Mol Genet 7:429-34. 1998
    ..are thought to be descended from a homologous pair of autosomes: a testis-determining allele which defined the Y chromosome arose, recombination between the nascent X and Y chromosomes became restricted and the Y chromosome gradually ..
  59. ncbi The Y chromosome effect on blood pressure in two European populations
    Fadi J Charchar
    British Heart Foundation Blood Pressure Group, Department of Medicine, University of Glasgow, United Kingdom
    Hypertension 39:353-6. 2002
    ..pressure (BP) in males compared with females is well documented and is thought to be influenced in part by the Y chromosome. To examine whether there is an association between BP and a polymorphic HindIII biallelic marker in the ..
  60. ncbi Re-sequencing regions of the ovine Y chromosome in domestic and wild sheep reveals novel paternal haplotypes
    J R S Meadows
    CSIRO Livestock Industries, 306 Carmody Road, St Lucia, QLD 4067, Australia
    Anim Genet 40:119-23. 2009
    The male-specific region of the ovine Y chromosome (MSY) remains poorly characterized, yet sequence variants from this region have the potential to reveal the wild progenitor of domestic sheep or examples of domestic and wild paternal ..
  61. ncbi Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)
    C K Hamilton
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Sex Dev 3:205-13. 2009
    Multi-copied gene families are prevalent in mammalian genomes, especially within the Y chromosome. Testis specific protein Y-encoded (TSPY) is present in variable copy number in many mammalian species...
  62. pmc Novel gene acquisition on carnivore Y chromosomes
    William J Murphy
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 2:e43. 2006
    Despite its importance in harboring genes critical for spermatogenesis and male-specific functions, the Y chromosome has been largely excluded as a priority in recent mammalian genome sequencing projects...
  63. ncbi Y chromosomes: born to be destroyed
    Sigrid Steinemann
    Institut für Molekulargenetik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Bioessays 27:1076-83. 2005
    ..They are more exposed to the decay process. (5) Gene dosage balance is re-established by the parallel evolution of dosage compensation mechanisms...
  64. ncbi Origin and evolution of the Drosophila Y chromosome
    A Bernardo Carvalho
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Postal 68011, CEP 21944 970, Caixa, Brazil
    Curr Opin Genet Dev 12:664-8. 2002
    ..Third and finally, Y chromosomes seem to have a strong effect on male fitness...
  65. pmc Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster
    Pan Pan Jiang
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 186:109-18. 2010
    The Y chromosome, inherited without meiotic recombination from father to son, carries relatively few genes in most species...
  66. pmc The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes
    E C Salido
    Howard Hughes Medical Institute, University of California School of Medicine, Harbor UCLA Medical Center, Torrance
    Am J Hum Genet 50:303-16. 1992
    ....
  67. pmc Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations
    F Marchetti
    Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
    Proc Natl Acad Sci U S A 104:17725-9. 2007
    ....
  68. ncbi A radiation hybrid map for the bovine Y Chromosome
    Wan Sheng Liu
    Department of Animal Science, College of Agricultural, Food, and Environmental Sciences, University of Minnesota, 305 Haecker Hall, 1364 Eckles Avenue, St Paul 55108, USA
    Mamm Genome 13:320-6. 2002
    Screening a bovine Y Chromosome-specific DNA library resulted in 34 new microsatellites, six of which mapped to the pseudoautosomal region (PAR), and 28 localized to the Y-specific region...
  69. pmc The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting
    Keith A Maggert
    The Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genetics 162:1245-58. 2002
    ..We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila melanogaster and found that all but one location showed differential expression of one or both ..
  70. ncbi Integrating Y-chromosome, mitochondrial, and autosomal data to analyze the origin of pig breeds
    O Ramirez
    Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Mol Biol Evol 26:2061-72. 2009
    ..The existence of Spanish and Portuguese commercial routes linking Asia with America might have favored the introduction of Far Eastern breeds into this continent...
  71. pmc Novel gene conversion between X-Y homologues located in the nonrecombining region of the Y chromosome in Felidae (Mammalia)
    J Pecon Slattery
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 97:5307-12. 2000
    Genes located on the mammalian Y chromosome outside of the pseudoautosomal region do not recombine with those on the X and are predicted to either undergo selection for male function or gradually degenerate because of an accumulation of ..
  72. ncbi Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities
    S K Mahadevaiah
    Laboratory of Developmental Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Hum Mol Genet 7:715-27. 1998
    An RNA-binding motif (RBM) gene family has been identified on the human Y chromosome that maps to the same deletion interval as the 'azoospermia factor' (AZF)...
  73. pmc The expansion of the PRAME gene family in Eutheria
    Ti Cheng Chang
    Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 6:e16867. 2011
    ..Conversely, selective constraints have operated on the expanded PRAMEYs to preserve their essential function in spermatogenesis...
  74. pmc Dog Y chromosomal DNA sequence: identification, sequencing and SNP discovery
    Christian Natanaelsson
    School of Biotechnology, KTH, Royal Institute of Technology, AlbaNova University Center, 10691 Stockholm, Sweden
    BMC Genet 7:45. 2006
    ..bp of non-repetitive dog Y-chromosome sequence deposited in GenBank, necessitating the identification of dog Y chromosome sequence and the search for polymorphisms therein...
  75. pmc Cytogenetic analysis of a segment of the Y chromosome of Drosophila melanogaster
    R W Hardy
    Genetics 107:591-610. 1984
    Males carrying a large deficiency in the long arm of the Y chromosome known to delete the fertility gene kl-2 are sterile and exhibit a complex phenotype: (1) First metaphase chromosomes are irregular in outline and appear sticky; (2) ..
  76. ncbi Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes
    Xuqi Chen
    Department of Physiological Science, University of California, Los Angeles, CA, USA
    Dev Neurobiol 68:265-73. 2008
    ..We also examined mice in which the testis-determining gene Sry is deleted from the Y chromosome but inserted onto an autosome as a transgene, producing XX and XY gonadal females and XX and XY gonadal males...
  77. ncbi Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain
    P Blanco
    Human Molecular Genetics Group, Division of Cellular and Molecular Pathology, University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, England, UK
    Mamm Genome 11:906-14. 2000
    ..The implications of Y-linked genes expressed predominantly in tissues and organs other than the testis are considered within the context of the concept of sexual selection...
  78. ncbi Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome
    Alison J Pearks Wilkerson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Genomics 92:329-38. 2008
    ..As a consequence of random decay and chromosome rearrangements over evolutionary time, Y chromosome gene repertoires differ between eutherian lineages...
  79. pmc Low conservation of gene content in the Drosophila Y chromosome
    Leonardo B Koerich
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944 970, Rio de Janeiro, Brazil
    Nature 456:949-51. 2008
    ..melanogaster Y chromosome is much younger...
  80. ncbi Low levels of nucleotide diversity in mammalian Y chromosomes
    Linda Hellborg
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 21:158-63. 2004
    ..The human Y chromosome shows levels of nucleotide diversity 20% that of autosomes, which is significantly less than expected when ..
  81. pmc Sex chromosome evolution: molecular aspects of Y-chromosome degeneration in Drosophila
    Doris Bachtrog
    Department of Ecology, Behavior and Evolution, University of California, San Diego, La Jolla, California 92093, USA
    Genome Res 15:1393-401. 2005
    Ancient Y-chromosomes of various organisms contain few active genes and an abundance of repetitive DNA. The neo-Y chromosome of Drosophila miranda is in transition from an ordinary autosome to a genetically inert Y-chromosome, while its ..
  82. pmc Hierarchical high-throughput SNP genotyping of the human Y chromosome using MALDI-TOF mass spectrometry
    Silvia Paracchini
    CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 30:e27. 2002
    ..primer extension/mass spectrometry method (the PinPoint assay) for high-throughput SNP genotyping of the human Y chromosome. 118 markers were used to define 116 haplogroups and typing was organised in a hierarchical fashion...
  83. ncbi Reduced introgression of the Y chromosome between subspecies of the European rabbit (Oryctolagus cuniculus) in the Iberian Peninsula
    A Geraldes
    CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
    Mol Ecol 17:4489-99. 2008
    The role of the Y chromosome in speciation is unclear. Hybrid zones provide natural arenas for studying speciation, as differential introgression of markers may reveal selection acting against incompatibilities...
  84. ncbi Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y
    Antonio Bernardo Carvalho
    Departamento de Genetica, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944 970, Rio de Janeiro, Brazil
    Science 307:108-10. 2005
    ..guanche and D. bifasciata, which shows that less than 18 million years ago the ancestral Drosophila Y chromosome was translocated to an autosome in the D. pseudoobscura lineage...
  85. pmc Phylogenetic distinctiveness of Middle Eastern and Southeast Asian village dog Y chromosomes illuminates dog origins
    Sarah K Brown
    Canid Diversity and Conservation Laboratory, Center for Veterinary Genetics, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e28496. 2011
    ..We used high-resolution Y chromosome markers (SNP and STR) and mitochondrial DNA to analyze 495 village dogs/dingoes from the Middle East and ..
  86. pmc Interchromosomal duplications on the Bactrocera oleae Y chromosome imply a distinct evolutionary origin of the sex chromosomes compared to Drosophila
    Paolo Gabrieli
    Department of Animal Biology, University of Pavia, Pavia, Italy
    PLoS ONE 6:e17747. 2011
    ..The tephritid Y chromosome is postulated to be necessary to determine male development...
  87. ncbi The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers
    G Mardon
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 56:765-70. 1989
    The ZFY gene, located in the sex-determining region of the human Y chromosome, appears to encode a zinc-finger protein. Two homologous genes, Zfy-1 and Zfy-2, are found in the sex-determining region of the mouse Y chromosome...
  88. ncbi Limited contribution of circulating cells to the development and maintenance of nonhematopoietic bovine tissues
    Mikael Niku
    Division of Anatomy, Department of Basic Veterinary Sciences, University of Helsinki, Helsinki, Finland
    Stem Cells 22:12-20. 2004
    ..In conclusion, circulating cells do not appear significant in the development and maintenance of nonhematopoietic bovine tissues, but may be important in regeneration and other special conditions...
  89. ncbi Fixed nucleotide differences on the Y chromosome indicate clear divergence between Equus przewalskii and Equus caballus
    B Wallner
    Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Veterinärplatz, Wien, Austria
    Anim Genet 34:453-6. 2003
    ..Here we report sequence variation from five newly identified Y chromosome regions of the horse...
  90. ncbi PCDH11 is X/Y homologous in Homo sapiens but not in Gorilla gorilla and Pan troglodytes
    N D Wilson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Cytogenet Genome Res 114:137-9. 2006
    ..This paper provides for the first time direct evidence for the absence of the PCDH11 genefrom the Y chromosome of chimpanzee (Pan troglodytes) as well as gorilla (Gorilla gorilla)...
  91. ncbi The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues
    C M Nagamine
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 4:63-74. 1990
    ..However, because the Zfy genes are apparently also expressed during spermatogenesis and in fetal organs other than testes, they may serve additional functions besides their postulated role in testis determination...
  92. ncbi Zfy gene expression patterns are not compatible with a primary role in mouse sex determination
    P Koopman
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, UK
    Nature 342:940-2. 1989
    The Y chromosome determines maleness in mammals. A Y chromosome-linked gene diverts the indifferent embryonic gonad from the default ovarian pathway in favour of testis differentiation, initiating male development...
  93. ncbi Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome
    G Mardon
    Whitehead Institute, Nine Cambridge Center, MA 02142
    Science 243:78-80. 1989
    The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF...
  94. pmc Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila
    Jun Zhou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:9941-6. 2012
    Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating the expression of numerous autosomal and X-linked genes...
  95. ncbi Chromosome-wide gene silencing initiates Y degeneration in Drosophila
    Qi Zhou
    Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Curr Biol 22:522-5. 2012
    ..Y-linked genes at the amino acid level? Here, we study patterns of gene expression of the recently formed neo-Y chromosome of Drosophila albomicans, which displays few signs of degeneration of protein-coding genes...
  96. pmc Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution
    Veronica J Murtagh
    Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
    Genome Res 22:498-507. 2012
    ..Thus, the small marsupial Y chromosome is surprisingly rich in ancient genes that are retained in at least Australian marsupials and evolved from ..
  97. pmc A large palindrome with interchromosomal gene duplications in the pericentromeric region of the D. melanogaster Y chromosome
    Maria Mendez-Lago
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Mol Biol Evol 28:1967-71. 2011
    The non-recombining Y chromosome is expected to degenerate over evolutionary time, however, gene gain is a common feature of Y chromosomes of mammals and Drosophila...
  98. ncbi Expression analysis of Y chromosome genes in human prostate cancer
    V K Dasari
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, San Francisco, California 94121, USA
    J Urol 165:1335-41. 2001
    PURPOSE: We hypothesized that alterations in Y chromosome gene expression may be associated with prostate cancer. To test this hypothesis we analyzed the expression of 19 Y chromosome genes in benign and malignant prostate tissue...
  99. ncbi The cutthroat trout Y chromosome is conserved with that of rainbow trout
    M A Alfaqih
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4236, USA
    Cytogenet Genome Res 121:255-9. 2008
    ..marker Omm1665, which maps close to the sex locus of Yellowstone cutthroat trout, was used to identify the Y chromosome of cutthroat trout in the hybrid...
  100. ncbi Development of Y chromosome intraspecific polymorphic markers in the Felidae
    Shu Jin Luo
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Hered 98:400-13. 2007
    b>Y chromosome haplotyping based on microsatellites and single nucleotide polymorphisms (SNPs) has proved to be a powerful tool for population genetic studies of humans...
  101. ncbi Patchy fur (Paf), a semidominant X-linked gene associated with a high level of X-Y nondisjunction in male mice
    P W Lane
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Hered 81:43-50. 1990
    ..The effect occurs only in male carriers and thus must extend into the proximal end of the XY pairing region...

Research Grants63

  1. Role of the Y-Located TSPY Gene in Human Oncogenesis
    Yun Fai Chris Lau; Fiscal Year: 2013
    ..The testis-specific protein Y-encoded (TSPY) gene is a tandemly repeated gene on the short arm of the human Y chromosome. Its 2...
  2. Mechanisms of Sex Determination in Zebrafish
    JOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013
    ....
  3. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..The novelty emerges from our recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many ..
  4. Role of Sex Chromosome Complement in the CNS during Autoimmune Disease
    Sienmi Du; Fiscal Year: 2013
    ..genotypes" (4CG) in which the Sry gene, which encodes for testicular development, has been deleted from the Y chromosome. This result in XX and XY- ovary-bearing females, where Y- denotes that the Sry gene was deleted and other Y ..
  5. Adult and Transgenerational Toxicity Due to Developmental TCDD Exposure
    Tracie R Baker; Fiscal Year: 2013
    ..The University of Wisconsin has numerous NIH-sponsored training programs, core facilities and funded researchers making it an ideal training environment for me to develop as an independent scientist. ..
  6. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    ..effect on disease outcomes and immune measures in Aims 1 and 2 is attributable to a gene unique to the Y chromosome versus the dosage of X genes...
  7. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    ..the expression of extracellular DNA in autoimmune mice using in vivo models including the expression of fetal Y chromosome DNA in the blood of pregnant mice to determine the impact of autoimmunity on the generation and clearance of ..
  8. Using a MALDI-TOF System for SNP Analysis
    Nadereh Jafari; Fiscal Year: 2010
    ....
  9. Sex-specific gene regulation of neuronal chloride co-transporter, kcc2
    WOLFGANG B LIEDTKE; Fiscal Year: 2010
    ....
  10. Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
    PHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010
    ..These will include measures of semen quality, ratio of X/Y chromosome-bearing sperm, chromatin stability of the sperm, sex ratio of births, and waiting time to pregnancy...
  11. Angiogenesis and Long-term Bone and Joint Allotransplant Survival
    Allen T Bishop; Fiscal Year: 2012
    ....
  12. Highly finished chromosome-based genome assembly for Anopheles gambiae
    Igor V Sharakhov; Fiscal Year: 2012
    ..gene-poor, repeat-rich heterochromatic regions is especially fragmented, and no gene from the heterochromatic Y chromosome has been found...
  13. Genomic Stability Functions of SMC Proteins in Germ Cells
    Raymond C Chan; Fiscal Year: 2013
    ..of meiotic sister-chromatid recombination is thought to generate disease-associated rearrangements of the Y chromosome (Lange et al., Cell 138, 855 (2009))...
  14. Evolutionary and functional diversification of chromatin proteins
    MIA TAUNA LEVINE; Fiscal Year: 2013
    ..Based on a combination of functional and phylogenetic data, the second aim tests the hypothesis that a Y chromosome-linked toxin-antitoxin system drives this revolving door of chromatin proteins that support a persistent male ..
  15. Do we need Y chromosome for successful reproduction?
    Monika A Ward; Fiscal Year: 2013
    ..A major factor associated with male infertility is Y chromosome deletions, yet our understanding of the requirement for specific genes on the Y chromosome and of their roles ..
  16. Gene Dosage in Mammalian Sexual Development
    ERIC J VILAIN; Fiscal Year: 2013
    ..factors protecting against XY sex reversal in the C57BL/6J-YPOS mouse model in which the combination of a Y chromosome originating from a domesticus strain (YPOS) and a C57BL/6J background results in disrupted testicular ..
  17. Molecular Evolution of Drosophila Y Chromosome
    Andrew G Clark; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Because the Y chromosome is present in just one copy and only in males, it faces a diminished capacity to purge deleterious mutations...
  18. Immunobiology of Tolerance FF Allogeneic Hematopoietic Cell Transplantation
    JOHN ANDREW HANSEN; Fiscal Year: 2013
    ..are characterized by the occurrence of donor (female) T cell responses against protein products of the Y chromosome - termed H-Y antigens - which are not possible in other donor-recipient combinations...
  19. Function of Guy1, a Y-specific gene of Anopheles stephensi
    Zhijian Jake Tu; Fiscal Year: 2013
    ..There is evidence that a dominant male-determining factor(s) on the Y chromosome initiates sexual differentiation in an Anopheles species...
  20. Minimum Y gene complement necessary for successful ART
    MONIKA WARD; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): It has been argued that most Y chromosome coded genes are likely to have roles in sperm production or function...
  21. Role of Stem Cells in Skeletal Aging
    Julie Glowacki; Fiscal Year: 2010
    ..This project is designed to reveal the effect of aging on marrow stromal cells'contribution to bone healing and the efficacy of a novel antioxidant on this process. ..
  22. Alcoholic Liver Diseases: Damage, Repair and Stem Cell Regeneration
    Zhaoli Sun; Fiscal Year: 2013
    ..or failure will be assessed with established labels, green fluorescent protein (GFP) transgenic Lewis rats, Y chromosome probes, and alloantibody in the case of Lewis to DA transplants...
  23. Asymmetric chromosome strand inheritance during stem cell division in Drosophila
    Swathi Yadlapalli; Fiscal Year: 2013
    ..Strikingly, in my preliminary study I found that GSCs preferentially inherit a certain strand of Y chromosome that is marked by the presence of satellite sequence (AATAC)6, while its complementary strand (GTATT)6 is ..
  24. The Genetics and Genomics of Sex-Ratio Meiotic Drive in Drosophila Affinis
    Robert L Unckless; Fiscal Year: 2013
    ..The Drosophila affinis sex-ratio system has an additional level o complexity: males lacking a Y chromosome are fertile...
  25. Characterization of the expression and function of DDX3Y in male blood cells
    KELLIE VIGNA ROSINSKI; Fiscal Year: 2010
    ..of female into male transplantation, because the Y chromosome encodes a set of male-specific alloantigens that can elicit potent immune responses from female donors...
  26. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..b>Y chromosome. To confirm the real-time PCR data engrafted MSCs will be visualized in brain sections by immunofluorescent ..
  27. Sex chromosome control of chromatin in the gametes
    BLUMA JESSICA LESCH; Fiscal Year: 2013
    ..Fulfillment of each of these aims will enhance our current understanding of sex-specific gamete development, and improve clinical approaches to disorders of fertility and early embryonic development. ..
  28. Genomic Basis of Vertebrate Diversity
    David M Kingsley; Fiscal Year: 2011
    ..adaptive change in many different natural populations around the world;3) assemble the stickleback proto Y chromosome and test whether either sex or autosomal rearrangements play an important role in generating phenotypic ..
  29. The Evolutionary and Functional Genomics of Dosage Compensation in Drosophila
    Doris Bachtrog; Fiscal Year: 2013
    ..Degeneration of the non-recombining Y chromosome is a general facet of sex chromosome evolution...
  30. "Gene Trafficking on an Evolving X Chromosome in Drosophila"
    Doris Bachtrog; Fiscal Year: 2013
    ..D.)miranda)therefore)provides)a)unique) system)to)study)the)mechanisms)of)gene)trafficking)on)an)evolving)X)chromosome) and)its)evolutionary)causes)in)action)using)a)comparative)and)functional)genomics) approach.) ..
  31. Elucidating the evolutionary mode of binding site gain at novel loci
    Christopher Ellison; Fiscal Year: 2013
    ..In addition, polymorphism data from wild D. miranda lines will be analyzed to determine if these binding sites evolved under positive selection, which has implications for the process of Y chromosome degeneration.
  32. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..However, a joint analysis of the relationships between the Y chromosome and androgens with respect to renal phenotypes has not been performed in men...
  33. Genomic Studies Mammalian Y Chromosomes
    David C Page; Fiscal Year: 2013
    ..Knowledge of the human Y chromosome sequence has allowed researchers to identify and characterize recurrent Y deletions, which have emerged as the ..
  34. GENETIC PATHWAYS CONTRIBUTING TO SLE PATHOGENESIS
    Edward K Wakeland; Fiscal Year: 2012
    ..We recently identified the genetic lesion underlying the potent autoimmune accelerating y chromosome locus (yaa) as a translocated TLR7 gene...
  35. Genomics of Pediatric Headache Disorders
    Andrew Hershey; Fiscal Year: 2006
    ..The results of this study should help in beginning to develop a molecular genomic approach for the diagnosis and treatment of different headache disorders. ..
  36. Role of Y chromosomal genes in male fertility
    Alexander I Agoulnik; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The critical role of Y chromosome in sex determination and male fertility is one of the basic paradigms in reproductive biology...
  37. SPECIES BOUNDARIES IN THE ANOPHELES GAMBIAE COMPLEX
    Nora Besansky; Fiscal Year: 2003
    ..gambia complex. The Y chromosome provides a powerful tool to attack questions at the population level and above, not only because it is ..
  38. Validating Sexual Behavior by Y-chromosome PCR
    Jonathan Zenilman; Fiscal Year: 2005
    ..Since Yc sampling requires only a vaginal swab, and is stable under field conditions, this test promises to be a practical and easily used biomarker for sexual behavior research. ..
  39. Y CHROMOSOME EVOLUTION AND MODERN HUMAN ORIGINS
    Michael Hammer; Fiscal Year: 1999
    The Y chromosome holds great promise for human evolutionary research...
  40. Molecular Mechanisms of Testis Development
    ANDREA CUPP; Fiscal Year: 2005
    ..The transcription factor directing testes development is Sry (Sex determining region of the Y chromosome)...
  41. SALIVARY GLAND TRANSGENIC MOUSE MODEL
    ELISA DURBAN; Fiscal Year: 1990
    ..male mouse transmitted the hybrid WAP-Ha-ras sequences only to the male progeny suggesting integration into the Y chromosome. Unexpectedly, this rare event resulted in WAP-Ha-ras expression only in the salivary glands of the male ..
  42. RAPID PRENATAL SEXING OF CLEAVING MOUSE EMBRYOS
    JON GORDON; Fiscal Year: 1992
    ..Thus, continued refinement of the process could eventually permit a complete genetic analysis of embryos, with the consequence that genetic diseases of any kind will be diagnosable prior to implantation...
  43. STRUCTURE AND FUNCTION OF EUKARYOTIC CHROMOSOMES
    Barbara Hamkalo; Fiscal Year: 1990
    ..This technique will be used to investigate the existence of mouse satellite sequences on the Y chromosome; the molecular basis of chromosomal rosettes; transcription of histone genes in somatic cells of the newt, ..
  44. Male Reproductive Effects from Exposure to Boron
    Wendie Robbins; Fiscal Year: 2005
    ..toxicity on male reproduction: total sperm count, sperm density, viability, motility, morphology, and sperm X:Y chromosome ratios sperm chromatin integrity measured by sperm chromatin structure assay (SCSA), COMET, TUNEL, protamine 1 (..
  45. Molecular Evolution of X-Y Meiotic Drive in Drosophila
    Andrew Clark; Fiscal Year: 2004
    ..Recent characterization of three dynein genes on the Drosophila Y chromosome allows us to quantify levels of polymorphism and dates of common ancestry of Y chromosomes of D. mediopunctata...
  46. GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    Holly Ingraham; Fiscal Year: 2000
    ..In choosing to study the initial activation of MIS gene expression, it is likely that these studies will shed light on basic molecular mechanisms underlying the development and maturation of reproductive endocrine organs. ..
  47. 2ND INTERNAT'L SYMPOSIUM OF VERTEBRATE SEX DETERMINATION
    Valentine Lance; Fiscal Year: 2000
    ..Since the discovery of the sex determining gene on the Y chromosome, SRY, in 1990 there have been many additional genes implicated in the process of sex determination...
  48. MICROCHIMERISM IN THE PATHOGENESIS OF PBC
    J Nelson; Fiscal Year: 2000
    ..Both disorders are poorly treated with available therapeutic agents. If microchimerism is involved in the pathogenesis of PBC, new therapies might be developed on this basis. ..
  49. Role of Y Chromosome Genes in Spermatogenesis
    Jan Rohozinski; Fiscal Year: 2004
    In most mammals, expression of a single dominant gene on the Y chromosome, SRY, directs differentiation of the bipotential embryonic gonads into testes and subsequent development of male characteristics...
  50. MALE INFERTILITY AND TESTIS RNA-BINDING PROTEINS
    PAULINE YEN; Fiscal Year: 1999
    ..Deleted in AZoospermia) is a gene family with four or more members, clustering on the long arm of the human Y chromosome. The gene cluster is deleted in about 10% of males-with idiopathic azoospermia or oligospermia...
  51. CLONING HOMOLOGOUS SEGMENTS OF HUMAN XP AND YQ
    PAULINE YEN; Fiscal Year: 1999
    ..However, her studies will be directed to deletion interval 6 of the Y chromosome. This region is clinically important because genes in this region have been implicated in spermatogenesis...
  52. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2004
    ....
  53. Tyrosine Hydroxylase Sry and Hypertension
    Daniel Ely; Fiscal Year: 2009
    ..These findings support our hypothesis that a locus on the Y chromosome can cause blood pressure to increase in an animal genetic model of hypertension as found in humans...
  54. RIBOSOMAL GENE REPLICATION DURING MAGNIFICATION
    SHARYN ENDOW; Fiscal Year: 1990
    ..We will also map the region of the Y chromosome that induces magnifying events in females and examine the basis for the instability of the magnified products...
  55. Mutation Rate Variation Among Human Genomic Regions
    Wen Hsiung Li; Fiscal Year: 2004
    ..the mutation rates among homologous sequences on different types of chromosome (autosomes, X chromosome, and Y chromosome)? The aim is to estimate the magnitude of difference between male and female mutation rates. 2...
  56. Potential Role of Fetal Stem Cells in Lung Tumor Development
    Janet Sawicki; Fiscal Year: 2009
    ..DNA extracted from lung tumors from women who have given birth to a baby boy or boys for the presence of the Y chromosome. Knowledge gained from this study may lead to the development of new therapies for lung cancer based on the ..
  57. SRY GENE REGULATION AND YP LOSS IN PROSTATE CARCINOMA
    JAMES TRICOLI; Fiscal Year: 1999
    DESCRIPTION: (adapted from the investigator's abstract) Loss of the Y chromosome is one of the most frequent cytogenetic abnormalities observed in human prostate cancer...
  58. Molecularly defined duplications for the X-chromosome and large autosomal genes
    Hugo Bellen; Fiscal Year: 2009
    ..e. one can use duplications of the X chromosome that are translocated onto the Y chromosome or an autosome to map essential genes on the X chromosome...
  59. Y CHROMOSOME AND HYPERTENSION
    Daniel Ely; Fiscal Year: 1999
    The long term objectives of this application are to understand the mechanisms by which the Y chromosome from spontaneously hypertensive rats (SHR) produces a significant blood pressure rise...
  60. Genetic Analysis of Germ Cell Formation
    Renee Reijo Pera; Fiscal Year: 2009
    ..Several Y chromosome loci that are required for germ cell development in men are absent in mice...
  61. PRIMARY SEX DETERMINATION AND FERTILITY IN MAMMALS
    COLIN BISHOP; Fiscal Year: 2003
    ..testis development, and possibly, a direct downstream target of Sry, the primary testis-determining gene on the Y chromosome. The first specific aim is to recreate Ods deletions in XY ES cells and generate new lines of mutant mice...
  62. Genetic Mechanisms of Mammalian Sex Determination
    KENNETH ALBRECHT; Fiscal Year: 2007
    ..B6 alleles of Wt1 and Sf1 are hypomorphs and that this reduced function causes decreased expression of Sry, the Y chromosome testis determining gene...
  63. FETAL GENE EXPRESSION IN MOUSE SEX DETERMINATION
    William Crain; Fiscal Year: 1999
    ..These mice carry the Y chromosome from Mus poschiavinus on the C57BL/6J(B6) genetic background and produce XY offspring that are either ..