minisatellite repeats

Summary

Summary: Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit. Minisatellite repeats are often called variable number of tandem repeats.

Top Publications

  1. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  2. pmc A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis
    Ik Young Choi
    Soybean Genomics and Improvement Laboratory, USDA, ARS, Beltsville, Maryland 20705, USA
    Genetics 176:685-96. 2007
  3. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009
  4. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
  5. ncbi PER3 polymorphism predicts sleep structure and waking performance
    Antoine U Viola
    Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Curr Biol 17:613-8. 2007
  6. pmc The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
    Cyril Ribeyre
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris, France
    PLoS Genet 5:e1000475. 2009
  7. pmc MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
    Thomas Weniger
    Department of Periodontology, University Hospital Munster, Munster, Germany
    Nucleic Acids Res 38:W326-31. 2010
  8. pmc Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei
    Horng Yunn Dou
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    BMC Infect Dis 8:170. 2008
  9. pmc Development of multiple-locus variable-number tandem-repeat analysis for molecular typing of Mycoplasma pneumoniae
    S Degrange
    Laboratoire de Bactériologie EA 3671, Mycoplasma and chlamydiae infections in humans, Universite Victor Segalen Bordeaux 2, CHU de Bordeaux, Bordeaux 33076 Cedex, France
    J Clin Microbiol 47:914-23. 2009
  10. pmc Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples
    Reinier J M Bom
    Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    J Clin Microbiol 49:2844-53. 2011

Research Grants

  1. MINISATELLITE SEQUENCES AND HOMOLOGOUS RECOMBINATION
    Peter Moore; Fiscal Year: 1991
  2. GENETIC EPIDEMIOLOGY
    Mary Claire King; Fiscal Year: 1990
  3. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2005
  4. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 1999
  5. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2006
  6. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2002
  7. Molecular Epidemiology of Alcoholism 2- Big Sibships
    RICHARD TODD; Fiscal Year: 2005
  8. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
  9. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2005
  10. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2002

Detail Information

Publications243 found, 100 shown here

  1. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  2. pmc A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis
    Ik Young Choi
    Soybean Genomics and Improvement Laboratory, USDA, ARS, Beltsville, Maryland 20705, USA
    Genetics 176:685-96. 2007
    ....
  3. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009
    ..Moreover, among eight dicot species used for comparison purposes, carrot BES had highest homology to protein-coding sequences from tomato. This deep-coverage library will aid carrot breeding and genetics...
  4. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
    ..The combined set of genetic markers and their integration into an improved genetic map should facilitate chickpea genetics and breeding, as well as translational studies between chickpea and Medicago...
  5. ncbi PER3 polymorphism predicts sleep structure and waking performance
    Antoine U Viola
    Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Curr Biol 17:613-8. 2007
    ..The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis...
  6. pmc The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
    Cyril Ribeyre
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris, France
    PLoS Genet 5:e1000475. 2009
    ..Hence, we conclude that CEB1 instability in pif1Delta cells depends on the potential to form G-quadruplex structures, suggesting that Pif1 could play a role in the metabolism of G4-forming sequences...
  7. pmc MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
    Thomas Weniger
    Department of Periodontology, University Hospital Munster, Munster, Germany
    Nucleic Acids Res 38:W326-31. 2010
    ..An extensive documentation guides users through all application functions...
  8. pmc Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei
    Horng Yunn Dou
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    BMC Infect Dis 8:170. 2008
    ..Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture...
  9. pmc Development of multiple-locus variable-number tandem-repeat analysis for molecular typing of Mycoplasma pneumoniae
    S Degrange
    Laboratoire de Bactériologie EA 3671, Mycoplasma and chlamydiae infections in humans, Universite Victor Segalen Bordeaux 2, CHU de Bordeaux, Bordeaux 33076 Cedex, France
    J Clin Microbiol 47:914-23. 2009
    ..The potential value of MLVA of M. pneumoniae as an epidemiological tool is discussed, and the use of the VNTR markers in further investigations of the potential use of MLVA in outbreaks of M. pneumoniae infections is proposed...
  10. pmc Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples
    Reinier J M Bom
    Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    J Clin Microbiol 49:2844-53. 2011
    ..This shows that the chlamydial genome in clinical specimens has an appropriate polymorphism to enable epidemiological cluster analysis using MLST and MLVA...
  11. ncbi The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
    S Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan
    Pharmacogenomics J 1:152-6. 2001
    ..This suggests that VNTR polymorphism affects the expression of the dopamine transporter...
  12. pmc Isolation and characterization of novel microsatellite markers and their application for diversity assessment in cultivated groundnut (Arachis hypogaea)
    Luu M Cuc
    International Crop Research Institute for Semi Arid Tropics, Patancheru 502 324, Greater Hyderabad, Andhra Pradesh, India
    BMC Plant Biol 8:55. 2008
    ..The low level of polymorphism in cultivated germplasm, however, warrants a need of larger number of polymorphic microsatellite markers for cultivated groundnut...
  13. pmc Characterization of the soybean genome using EST-derived microsatellite markers
    Hiroshi Hisano
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 14:271-81. 2007
    ....
  14. pmc Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis
    Erin P Price
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
    PLoS Pathog 6:e1000725. 2010
    ....
  15. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  16. doi Evaluation of 24 locus MIRU-VNTR genotyping of Mycobacterium tuberculosis isolates in Canada
    Sara Christianson
    National Microbiology Laboratory, 1015 Arlington Avenue, Winnipeg, Manitoba R3E 3R2, Canada
    Tuberculosis (Edinb) 90:31-8. 2010
    ..For long-term surveillance of MTBC within Canada, the use of 24 MIRU-VNTR loci will provide rapid, highly discriminatory molecular epidemiology information...
  17. pmc Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF
    Fahad R Ali
    School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Neurochem 112:296-306. 2010
    ..We suggest that the potential for interaction between multiple polymorphic domains should be incorporated into genetic association studies...
  18. doi Genetic diversity of the Mycobacterium tuberculosis Beijing family in East Asia revealed through refined population structure analysis
    Takayuki Wada
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan
    FEMS Microbiol Lett 291:35-43. 2009
    ..Our results reflect the singular genetic diversity and the epidemiological pattern of Beijing M. tuberculosis in Japan...
  19. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  20. ncbi Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area
    Philip Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, Cedex, France
    Mol Microbiol 47:529-38. 2003
    ..This linkage disequilibrium was also evident when the MIRU-VNTR types were compared with the IS6110 restriction fragment length polymorphism types. These results support a predominant clonal evolution of M. tuberculosis...
  21. doi Bin mapping of genomic and EST-derived SSRs in melon (Cucumis melo L.)
    I Fernández-Silva
    IRTA, Centre de Recerca en Agrigenòmica CSIC IRTA UAB CRAG, Carretera de Cabrils, Km 2, 08348, Cabrils, Barcelona, Spain
    Theor Appl Genet 118:139-50. 2008
    ..A final bin-map was constructed including 80 RFLPs, 212 SSRs, 3 SNPs and the Nsv locus, distributed in 122 bins with an average bin length of 10.2 cM and a maximum bin length of 33 cM. Map density was 4.2 cM/marker or 5.9 cM/SSR...
  22. ncbi Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay
    Bjørn Arne Lindstedt
    Norwegian Institute of Public Health, Division for Infectious Diseases Control, N 0403 Oslo, Norway
    J Microbiol Methods 69:197-205. 2007
    ..Shigella isolates were of species S. flexneri, S. boydii, S. sonnei and S. dysenteriae. The MLVA method rapidly genotyped all isolates in the study at a Simpson's index of diversity of D=0.98...
  23. ncbi Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 64:585-90. 2007
    ..Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD)...
  24. pmc Three-year population-based evaluation of standardized mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing of Mycobacterium tuberculosis
    Caroline Allix-Béguec
    Molecular Mechanisms of Bacterial Pathogenesis, INSERM U629, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, F 59021 Lille cedex, France
    J Clin Microbiol 46:1398-406. 2008
    ..g., large sequence polymorphisms. Our results reinforce the proposal of standardized MIRU-VNTR typing as a new reference genotyping method for the epidemiological and phylogenetic screening of M. tuberculosis strains...
  25. pmc Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China
    Wei Wei Jiao
    Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    J Clin Microbiol 46:1045-9. 2008
    ..tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required...
  26. pmc MLVA-16 typing of 295 marine mammal Brucella isolates from different animal and geographic origins identifies 7 major groups within Brucella ceti and Brucella pinnipedialis
    Marianne Maquart
    INRA, UR1282, Infectiologie Animale et Sante Publique, IASP, Nouzilly, F 37380, France
    BMC Microbiol 9:145. 2009
    ..A previously published assay comprising 16 loci (MLVA-16) that has been shown to be highly relevant and efficient for typing and clustering Brucella strains from animal and human origin was used...
  27. pmc Multiple-locus variable-number tandem-repeat analysis is a suitable tool for differentiation of Mycoplasma hyopneumoniae strains without cultivation
    K Vranckx
    Department of Pathology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Clin Microbiol 49:2020-3. 2011
    ..The test had a discriminatory index of >0.99 and was applied reliably to porcine bronchoalveolar lavage fluid and tracheal swabs...
  28. pmc High throughput multiple locus variable number of tandem repeat analysis (MLVA) of Staphylococcus aureus from human, animal and food sources
    Daniel Sobral
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR 8621, Orsay, France
    PLoS ONE 7:e33967. 2012
    ..Interestingly, isolates responsible for food poisoning show a CC distribution signature typical of human isolates and strikingly different from animal isolates, suggesting a predominantly human origin...
  29. ncbi A comparison of simple sequence repeat and single nucleotide polymorphism marker technologies for the genotypic analysis of maize (Zea mays L.)
    E S Jones
    Pioneer Hi Bred International Inc DuPont Agriculture and Nutrition, 7300 NW 62nd Avenue, Johnston, IA 51031 1004, USA
    Theor Appl Genet 115:361-71. 2007
    ....
  30. ncbi Genetic diversity of O157:H7 and non-O157 verocytotoxigenic Escherichia coli from Argentina inferred from multiple-locus variable-number tandem repeat analysis (MLVA)
    Ana V Bustamante
    Lab Inmunoquímica y Biotecnología, Dto de Sanidad Animal y Medicina Preventiva, Facultad de Cs Veterinarias, Universidad Nacional del Centro de la Pcia de Buenos Aires, 7000 Tandil, Buenos Aires, Argentina
    Int J Med Microbiol 300:212-7. 2010
    ....
  31. doi Rapid and high resolution genotyping of all Escherichia coli serotypes using 10 genomic repeat-containing loci
    Inger Løbersli
    Division of Infectious Diseases Control, Norwegian Institute of Public Health, Lovisenberggata 8, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    J Microbiol Methods 88:134-9. 2012
    ..The GECM7 method was improved by adding three new repeat-loci to a total of ten (GECM10), and a considerable increase in resolution was observed (from 296 to 507 genotypes on the same set of strains)...
  32. ncbi Allelic diversity of variable number of tandem repeats provides phylogenetic clues regarding the Mycobacterium tuberculosis Beijing family
    Takayuki Wada
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8 34 Tojo cho, Tennoji ku, Osaka 543 0026, Japan
    Infect Genet Evol 9:921-6. 2009
    ..It is suggested that VNTR typing can elucidate genetic markers representing the phylogenetic classification in the lineage...
  33. pmc Investigation on Mycobacterium tuberculosis diversity in China and the origin of the Beijing clade
    Kanglin Wan
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR 8621, Orsay, France
    PLoS ONE 6:e29190. 2011
    ..In order to examine the strain diversity in the whole country, and to study the evolutionary development of Beijing strains, we sought to genotype a large collection of isolates using different methods...
  34. pmc Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
    Ingrid Olsen
    Centre for Molecular Biology and Neuroscience, Institute of Microbiology, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway
    FEMS Immunol Med Microbiol 56:151-61. 2009
    ..This is the first example of such a tandem repeat region of variable length being linked to the expression level of a bacterial gene...
  35. ncbi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida, USA
    Nat Genet 15:293-7. 1997
    ..Higher levels of (pro)insulin in the thymus may promote negative selection (deletion) of insulin-specific T-lymphocytes which play a critical role in the pathogenesis of type-1 diabetes...
  36. doi Mathematical modelling of Mycobacterium tuberculosis VNTR loci estimates a very slow mutation rate for the repeats
    Andrew Grant
    Statistics Unit, Statistics, Modelling and Bioinformatics Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Mol Evol 66:565-74. 2008
    ..This suggests that the VNTR profile of a strain of M. tuberculosis will be indicative of its clonal lineage and will be unlikely to vary in epidemiologically-related strains...
  37. doi Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Hum Brain Mapp 32:1557-65. 2011
    ....
  38. ncbi Genetic variability and genetic structure of wild and semi-domestic populations of tasar silkworm (Antheraea mylitta ) ecorace Daba as revealed through ISSR markers
    P K Kar
    Central Sericultural Germplasm Resources Centre, Central Silk Board, Thally Road, P B 44635109 Hosur, Tamil Nadu, India
    Genetica 125:173-83. 2005
    ..The high genetic variability present within wild Daba population of A. mylitta is of much importance for conservation as well as utilization in systematic breeding program...
  39. ncbi Impact of homoplasy on variable numbers of tandem repeats and spoligotypes in Mycobacterium tuberculosis
    Josephine F Reyes
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Infect Genet Evol 12:811-8. 2012
    ..However, deep phylogenetic inferences using spoligotypes or VNTRs with a small number of loci are likely to be unreliable...
  40. ncbi Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosis
    Josephine F Reyes
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Infect Genet Evol 10:1046-51. 2010
    ..These findings confirm the high level of discrimination observed using multilocus VNTR typing, and suggest that caution should be taken not to underestimate the extent of recent transmission when using this marker...
  41. ncbi A composite linkage map from two crosses for the species complex Picea mariana x Picea rubens and analysis of synteny with other Pinaceae
    Betty Pelgas
    Chaire de recherche du Canada en génomique forestière et environnementale, Centre de recherche en biologie forestière, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, QC, G1K 7P4, Canada
    Theor Appl Genet 111:1466-88. 2005
    ..Implications for the evolution of the Pinaceae genome are discussed...
  42. pmc Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis
    Jacob Kurniawan
    University of New South Wales, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:297-300. 2010
    ..Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia...
  43. doi Culture-independent multi-locus variable-number tandem-repeat analysis (MLVA) of Mycoplasma pneumoniae
    Roger Dumke
    Dresden University of Technology, Medical Faculty Carl Gustav Carus, Institute of Medical Microbiology and Hygiene, Fetscherstrasse 74, d, 01307 Dresden, Germany
    J Microbiol Methods 86:393-6. 2011
    ..pneumoniae-positive pneumonia patients. The method resulted in a clearly identifiable MLVA type in all samples tested and can be used for MLVA without laborious isolation of the pathogen...
  44. doi Genetic characterization of non-O157 verocytotoxigenic Escherichia coli isolated from raw beef products using multiple-locus variable-number tandem repeat analysis
    Tomás Franci
    Laboratorio de Inmunoquimica y Biotecnologia, Departamento de Sanidad Animal y Medicina Preventiva, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina
    Foodborne Pathog Dis 8:1019-23. 2011
    ..As some VNTR markers might be serotype specific, it is possible that the implementation of new VNTR loci will increase intraserotype discrimination...
  45. doi Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
    Ronghuan Wang
    Institute of Crop Science, Chinese Academy of Agricultural Sciences National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI, 100081 Beijing, People s Republic of China
    Theor Appl Genet 117:1141-53. 2008
    ..75-40.28% in the subgroups. Among factors influencing LD, linkage was the major cause for LD of SSR loci. The results suggested that the population may be used in the detection of genome-wide SSR marker-phenotype association...
  46. ncbi Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression
    Dubravka Hranilovic
    Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Genetics, Rudjer Boskovic Institute, Zagreb, Croatia
    Biol Psychiatry 55:1090-4. 2004
    ....
  47. ncbi EST-SSRs as a resource for population genetic analyses
    J R Ellis
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Heredity (Edinb) 99:125-32. 2007
    ..We then discuss the advantages and disadvantages of EST-SSRs in the context of population genetic applications...
  48. doi Development of chickpea EST-SSR markers and analysis of allelic variation across related species
    Shalu Choudhary
    National Institute of Plant Genome Research, Post Box Number 10531, Aruna Asaf Ali Marg, Jawaharlal Nehru University Campus, New Delhi, 110067, India
    Theor Appl Genet 118:591-608. 2009
    ....
  49. pmc Mycobacterium tuberculosis ecology in Venezuela: epidemiologic correlates of common spoligotypes and a large clonal cluster defined by MIRU-VNTR-24
    Edgar Abadia
    Laboratorio de Genetica Molecular, CMBC, Instituto Venezolano de Investigaciones Cientificas IVIC, 1020A Caracas, Venezuela
    BMC Infect Dis 9:122. 2009
    ..tuberculosis strains isolated in Venezuela from 1997 to 2006, predominantly from two large urban centers and two geographically distinct indigenous areas, and then studied a subgroup with MIRU-VNTR 24 loci...
  50. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  51. ncbi Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia
    J B Fan
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:928-38, 891. 2005
    ....
  52. pmc Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes
    Francesca M Filbey
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Alcohol Clin Exp Res 32:1113-23. 2008
    ..However, to date, the mechanisms that underlie these differences remain largely unknown...
  53. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
    ..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD...
  54. pmc A real-time PCR array for hierarchical identification of Francisella isolates
    Kerstin Svensson
    Division of CBRN Defense and Security, Swedish Defense Research Agency, Umea, Sweden
    PLoS ONE 4:e8360. 2009
    ....
  55. pmc Vibrio cholerae strain typing and phylogeny study based on simple sequence repeats
    Yael Danin-Poleg
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Clin Microbiol 45:736-46. 2007
    ..Furthermore, discrimination between 27 strains of the 32 strains was achieved. SSR-based typing methods combining L-SSR and MNR-MLST were found to be efficient for V. cholerae typing...
  56. pmc An interspecific linkage map of SSR and intronic polymorphism markers in tomato
    Kenta Shirasawa
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba, 292 0818, Japan
    Theor Appl Genet 121:731-9. 2010
    ..Information on the DNA markers developed in this study is available at http://www.kazusa.or.jp/tomato/...
  57. ncbi Construction of BAC and BIBAC libraries and their applications for generation of SSR markers for genome analysis of chickpea, Cicer arietinum L
    J Lichtenzveig
    Institute of Plant Science and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, 76100, Israel
    Theor Appl Genet 110:492-510. 2005
    ..The BAC and BIBAC libraries and new SSR markers will provide valuable resources for chickpea genomics research and breeding (the libraries and their filters are available to the public at http://hbz.tamu.edu)...
  58. pmc Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  59. pmc Genotyping and phylogenetic analysis of Yersinia pestis by MLVA: insights into the worldwide expansion of Central Asia plague foci
    Yanjun Li
    Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 4:e6000. 2009
    ....
  60. pmc Use of variable-number tandem-repeat typing to differentiate Mycobacterium tuberculosis Beijing family isolates from Hong Kong and comparison with IS6110 restriction fragment length polymorphism typing and spoligotyping
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 43:314-20. 2005
    ..However, VNTR-defined clusters should be subtyped with IS6110 RFLP for maximal resolution...
  61. pmc Genetic diversity of Mycobacterium tuberculosis isolates from a tertiary care tuberculosis hospital in South Korea
    Isdore Chola Shamputa
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Microbiol 48:387-94. 2010
    ..tuberculosis Beijing strains. Within the study limits, our results also suggest that the problem of drug-resistant TB in the Republic of Korea may be largely due to acquired resistance as opposed to transmission...
  62. doi Highly polymorphic variable-number tandem repeats loci for differentiating Beijing genotype strains of Mycobacterium tuberculosis in Shanghai, China
    Lu Zhang
    Shanghai Medical College, Fudan University, Shanghai, China
    FEMS Microbiol Lett 282:22-31. 2008
    ..tuberculosis isolates in population-based epidemiologic studies of M. tuberculosis transmission in Shanghai, China...
  63. pmc Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
    J Clin Microbiol 39:3563-71. 2001
    ..tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen...
  64. pmc Sequencing Medicago truncatula expressed sequenced tags using 454 Life Sciences technology
    Foo Cheung
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    BMC Genomics 7:272. 2006
    ....
  65. doi Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy
    Dinesh K Ahirwar
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Biomarkers 14:213-8. 2009
    ..37) and enhanced (HR 2.24) risk of recurrence after BCG immunotherapy, respectively. The study suggests that cytokine gene variants may modulate CaB susceptibility and risk of recurrence after BCG immunotherapy...
  66. doi Origins and colonization history of pandemic Vibrio parahaemolyticus in South America
    Juan Ansede-Bermejo
    Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Mol Ecol 19:3924-37. 2010
    ....
  67. doi Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers
    Wei Yen Lim
    Department of Epidemiology and Public Health National University of Singapore, and Department of Pathology, Tan Tock Seng Hospital, Singapore, Singapore
    Carcinogenesis 32:522-9. 2011
    ..47). Our results suggest that the effect of inflammatory medical conditions on lung cancer in never-smokers is modulated by host genetic susceptibility and will need to be confirmed in other studies conducted in similar populations...
  68. doi A novel isolation method of Brucella species and molecular tracking of Brucella suis biovar 2 in domestic and wild animals
    Carlos Abril
    Centre for Zoonoses, Bacterial Animal Diseases and Antimicrobial Resistance ZOBA, Langgass strasse 122, Postfach 8466, CH 3001 Bern, Switzerland
    Vet Microbiol 150:405-10. 2011
    ..This work demonstrates that MLVA-16 is an excellent tool for both monitoring brucellosis and investigating outbreaks. Additionally, we present efficient alternatives for the isolation of Brucella spp...
  69. pmc High-throughput typing method to identify a non-outbreak-involved Legionella pneumophila strain colonizing the entire water supply system in the town of Rennes, France
    D Sobral
    Universite Paris Sud, Institut de Genetique et Microbiologie, 91405 Orsay, France
    Appl Environ Microbiol 77:6899-907. 2011
    ..This work illustrates the potential of the high-throughput MLVA typing method to investigate the origin of legionellosis cases by allowing the systematic typing of any new isolate and inclusion of data in shared databases...
  70. pmc Multiple-locus variable-number tandem-repeat analysis for clonal identification of Vibrio parahaemolyticus isolates by using capillary electrophoresis
    Erika Harth-Chu
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Braunschweig, Germany
    Appl Environ Microbiol 75:4079-88. 2009
    ..The developed approach enables rapid and high-resolution analysis of V. parahaemolyticus with pandemic potential and provides a new surveillance tool for food-borne pathogens...
  71. doi Phylogeography of Francisella tularensis ssp. holarctica in France
    A J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
    Lett Appl Microbiol 52:177-80. 2011
    ..To investigate the phylogeography of French Francisella tularensis ssp. holarctica isolates...
  72. doi MAOA gene polymorphisms and response to mirtazapine in major depression
    Dong Sheng Tzeng
    Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan
    Hum Psychopharmacol 24:293-300. 2009
    ..Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD)...
  73. doi Different Mycobacterium avium subsp. paratuberculosis MIRU-VNTR patterns coexist within cattle herds
    K J E van Hulzen
    Department of Farm Animal Health, Utrecht University, PO Box 80 151, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 148:419-24. 2011
    ..These data indicate that such multiple genotypes of MAP can coexist within one herd...
  74. ncbi Family-based and case-control association studies of DRD4 and DAT1 polymorphisms in Chinese attention deficit hyperactivity disorder patients suggest long repeats contribute to genetic risk for the disorder
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing 100 083, China
    Am J Med Genet B Neuropsychiatr Genet 128:84-9. 2004
    ..An exploratory stratification by gender suggests that long-repeat alleles of DRD4 and DAT1 may increase the risk for ADHD in Han Chinese children...
  75. ncbi Mycobacterial interspersed repetitive units (MIRU) differentiate Mycobacterium avium subspecies paratuberculosis from other species of the Mycobacterium avium complex
    T J Bull
    Department of Surgery, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Mol Cell Probes 17:157-64. 2003
    ..avium complex (MAC) tested. PCR at both loci 1 and 4 also distinguished MAP from Mycobacterium intracellulare. MIRU typing may provide an additional simple and rapid procedure for the differentiation between MAP and other MAC...
  76. doi Genetic diversity in domesticated soybean (Glycine max) and its wild progenitor (Glycine soja) for simple sequence repeat and single-nucleotide polymorphism loci
    Ying Hui Li
    The National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI Key Lab of Germplasm Utilization MOA, Institute of Crop Science, Chinese Academy of Agricultural Sciences, 100081 Beijing, China
    New Phytol 188:242-53. 2010
    ..soja and G. max represent distinct germplasm pools. Limited evidence of admixture was discovered between these two species. Overall, our analyses are consistent with the origin of G. max from regions along the Yellow River of China...
  77. doi Genetic structure and differentiation of Oryza sativa L. in China revealed by microsatellites
    Dongling Zhang
    Key Laboratory of Crop Genomics and Genetic Improvement of Ministry of Agriculture, and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, People s Republic of China
    Theor Appl Genet 119:1105-17. 2009
    ..Allele size was also negatively correlated with latitude and altitude, and this may be interpreted by different mutation rates, selection pressures, and population size effects under different environments and cropping systems...
  78. doi Development of SSR markers derived from SSR-enriched genomic library of eggplant (Solanum melongena L.)
    Tsukasa Nunome
    National Institute of Vegetable and Tea Science NIVTS, National Agriculture and Food Research Organization NARO, 360 Kusawa, Ano, Tsu, Mie 514 2392, Japan
    Theor Appl Genet 119:1143-53. 2009
    ..The linkage map spans a total length of 959.1 cM, with an average marker distance of 4.3 cM. The markers should be a useful resource for qualitative and quantitative trait mapping and for marker-assisted selection in eggplant breeding...
  79. doi Molecular characterization of Mycobacterium avium subspecies paratuberculosis Types II and III isolates by a combination of MIRU-VNTR loci
    Elena Castellanos
    Centro de Vigilancia Sanitaria Veterinaria VISAVET, Universidad Complutense de Madrid, Avda Puerta de Hierro, 28040 Madrid, Spain
    Vet Microbiol 144:118-26. 2010
    ..Therefore, this MIRU-VNTR approach could be a useful sub-typing molecular tool in order to get a better sense of the epidemiology of Johne's disease...
  80. doi A consensus linkage map identifies genomic regions controlling fruit maturity and beta-carotene-associated flesh color in melon (Cucumis melo L.)
    H E Cuevas
    Department of Plant Breeding and Plant Genetics, University of Wisconsin Madison, Madison, WI, USA
    Theor Appl Genet 119:741-56. 2009
    ....
  81. pmc D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
    J Gelernter
    Psychiatry 116A2, VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Am J Hum Genet 61:1144-52. 1997
    ..We conclude that the most likely explanation of these results is that the DRD4 VNTR does not influence directly the trait of novelty seeking, in these samples...
  82. pmc Evaluation of the epidemiologic utility of secondary typing methods for differentiation of Mycobacterium tuberculosis isolates
    Awewura Kwara
    Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    J Clin Microbiol 41:2683-5. 2003
    ..MIRU-VNTR performed slightly better than spoligotyping in reducing the number of clustered isolates and the sizes of the clusters. All epidemiologically related isolates remained clustered by MIRU-VNTR but not by spoligotyping...
  83. ncbi Integration of simple sequence repeat (SSR) markers into a molecular linkage map of common bean (Phaseolus vulgaris L.)
    K Yu
    Agriculture and Agri Food Canada, Greenhouse and Processing Crops Research Center, Harrow, Ontario
    J Hered 91:429-34. 2000
    ..These SSR markers were stable and easy to assay by polymerase chain reaction (PCR). They should be useful markers for genetic mapping, genotype identification, and marker-assisted selection of common beans...
  84. pmc Molecular characteristics of strains of the cameroon family, the major group of Mycobacterium tuberculosis in a country with a high prevalence of tuberculosis
    Sara Ngo Niobe-Eyangoh
    Centre National de Reference des Mycobacteries, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    J Clin Microbiol 42:5029-35. 2004
    ..The knowledge of this particular genotype, with its large involvement in tuberculosis in Cameroon, allows greater refinement of tuberculosis transmission studies by interpreting data in the context of this geographic area...
  85. pmc High resolution, on-line identification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing
    Philippe Le Fleche
    Centre d Etudes du Bouchet BP3, 91710 Vert le Petit, France
    BMC Microbiol 2:37. 2002
    ..tuberculosis by summarising the existing data, developing additional markers, and setting up a freely accessible, fast, and easy to use, internet-based service for strain identification...
  86. ncbi Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, France
    Mol Microbiol 36:762-71. 2000
    ..Of the 12 variable loci, only one was found to vary among genealogically distant BCG substrains, suggesting that these interspersed bacterial minisatellite-like structures evolve slowly in mycobacterial populations...
  87. ncbi A 1,000-loci transcript map of the barley genome: new anchoring points for integrative grass genomics
    Nils Stein
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, 06466, Gatersleben, Germany
    Theor Appl Genet 114:823-39. 2007
    ..It provides new anchor points for detailed studies in comparative grass genomics and will support future attempts towards the integration of genetic and physical mapping information...
  88. ncbi A panel of microsatellite and minisatellite markers for the characterisation of field isolates of Theileria parva
    C A L Oura
    Department of Microbiology and Parasitology, Veterinary Faculty, University of Makerere, P O Box 7062, Kampala, Uganda
    Int J Parasitol 33:1641-53. 2003
    ..parva. Cluster analysis of multilocus genotypes from the 14 isolates (using a neighbour joining algorithm) revealed that genetic similarity between isolates was not obviously related to their geographical origin...
  89. doi Comparative mapping of DNA sequences in rye (Secale cereale L.) in relation to the rice genome
    B Hackauf
    Julius Kühn Institute, Federal Research Institute for Cultivated Plants, Institute for Breeding Research on Agricultural Crops, Erwin Baur Str 27, 06484, Quedlinburg, Germany
    Theor Appl Genet 118:371-84. 2009
    ..Furthermore, the aligned markers provide genomic anchor points between rye and rice, enabling the identification of conserved ortholog set markers for rye. Perspectives of rice as a model for genome analysis in rye are discussed...
  90. doi An optimized, multiplexed multi-locus variable-number tandem repeat analysis system for genotyping Francisella tularensis
    A J Vogler
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Lett Appl Microbiol 48:140-4. 2009
    ....
  91. pmc A fast and cost-effective approach to develop and map EST-SSR markers: oak as a case study
    Jérôme Durand
    INRA, UMR1202 BIOGECO, F 33610 Cestas, France
    BMC Genomics 11:570. 2010
    ..We also compared the level of polymorphism between genomic and EST-derived SSRs and address the transferability of EST-SSRs in Castanea sativa (chestnut)...
  92. pmc Comparison of quantitative trait loci for adaptive traits between oak and chestnut based on an expressed sequence tag consensus map
    Manuela Casasoli
    INRA, UMR Biodiversité Gènes et Ecosystèmes, 33612 Cestas Cedex, France
    Genetics 172:533-46. 2006
    ..No QTL for carbon isotope discrimination was conserved between the two species. Putative candidate genes for bud burst can be identified on the basis of colocations between EST-derived markers and QTL...
  93. ncbi Eucalyptus microsatellites mined in silico: survey and evaluation
    R Yasodha
    Division of Plant Biotechnology, Institute of Forest Genetics and Tree Breeding, P O Box 1061, Forest Campus, Coimbatore 641 002, India
    J Genet 87:21-5. 2008
    ..Evaluation of the usefulness of the SSRs showed that EST-derived SSRs can generate polymorphic markers as all the primers showed allelic diversity among the 16 provenances of E. tereticornis...
  94. doi Development of a set of public SSR markers derived from genomic sequence of a rapid cycling Brassica oleracea L. genotype
    Federico L Iniguez-Luy
    Department of Agronomy, University of Wisconsin Madison, 1575 Linden Drive, Madison, WI 53706, USA
    Theor Appl Genet 117:977-85. 2008
    ..Brassica genomic DNA sequence information is a promising resource for developing a large number of SSR molecular markers in Brassica species...
  95. pmc Organization and differential expression of the GACA/GATA tagged somatic and spermatozoal transcriptomes in Buffalo Bubalus bubalis
    Jyoti Srivastava
    Molecular Genetics Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    BMC Genomics 9:132. 2008
    ..Moreover, the distribution of GACA and GATA repeats in the prokaryotic and eukaryotic genomes was studied to highlight their significance in genome evolution...
  96. ncbi A new integrated genetic linkage map of the soybean
    Q J Song
    Soybean Genomics and Improvement Laboratory, USDA ARS, Beltsville, MD 20705, USA
    Theor Appl Genet 109:122-8. 2004
    ..Development of SSR markers from map-referenced BAC clones was a very effective means of targeting markers to marker-scarce positions in the genome...
  97. pmc Discriminatory ability of hypervariable variable number tandem repeat loci in population-based analysis of Mycobacterium tuberculosis strains, London, UK
    Preya Velji
    Barts and the London School of Medicine, Queen Mary, University of London, London, UK
    Emerg Infect Dis 15:1609-16. 2009
    ..909. Hypervariable loci should be included in standardized panels because they can provide consistent comparable results at multiple settings, provided the proposed conditions are adhered to...
  98. pmc Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism
    John A Groeger
    Surrey Sleep Research Centre, Guildford, UK
    Sleep 31:1159-67. 2008
    ....
  99. pmc Molecular typing of Mycobacterium tuberculosis by using nine novel variable-number tandem repeats across the Beijing family and low-copy-number IS6110 isolates
    R Scott Spurgiesz
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011 5640, USA
    J Clin Microbiol 41:4224-30. 2003
    ..These nine loci provide a useful, discriminatory extension of VNTR typing methods for application to molecular epidemiologic studies of M. tuberculosis...
  100. doi Multiple locus variable number of tandem repeats analysis
    Gilles Vergnaud
    DGA D4S Mission pour la Recherche et l Innovation Scientifique MRIS, Armees, and Department of Genetics and Microbiology, University of Paris XI, Orsay, France
    Methods Mol Biol 551:141-58. 2009
    ..Finally, even if the underlying principles are relatively simple, quality standards must be implemented before this approach is widely accepted, and technology issues must be resolved to further lower the typing costs...
  101. pmc Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s
    Leo M Schouls
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Bacteriol 186:5496-505. 2004
    ..Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected...

Research Grants123 found, 100 shown here

  1. MINISATELLITE SEQUENCES AND HOMOLOGOUS RECOMBINATION
    Peter Moore; Fiscal Year: 1991
    ..an extensive analysis of the products of recombination and analysis of the affects of distance and heterology between the minisatellites and the recombination events and of the number of minisatellite repeats present in the substrates.
  2. GENETIC EPIDEMIOLOGY
    Mary Claire King; Fiscal Year: 1990
    ..Second, we will explore whether hormonally-related risk factors for breast cancer can be expressions of genetic susceptibility by comparing susceptible and non-susceptible women in the families...
  3. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  4. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 1999
    ..Once identified, the extended families will be an important resource for future studies to identify genetic etiologies of ADHD. ..
  5. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2006
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  6. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2002
    ..abstract_text> ..
  7. Molecular Epidemiology of Alcoholism 2- Big Sibships
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  8. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  9. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  10. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2002
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  11. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  12. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  13. Epidemiological Investigations of ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  14. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  15. Molecular Epidemiology of Alcoholism 2- Big Sibships
    RICHARD TODD; Fiscal Year: 2003
    ..abstract_text> ..
  16. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2002
    ..abstract_text> ..
  17. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2003
    ..abstract_text> ..
  18. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  19. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2003
    ..abstract_text> ..
  20. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2000
    ..Once identified, the extended families will be an important resource for future studies to identify genetic etiologies of ADHD. ..
  21. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  22. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  23. Molecular Epidemiology of Alcoholism 2- Big Sibships
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  24. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  25. Molecular Genetics of Inattention in Australia
    RICHARD TODD; Fiscal Year: 2005
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  26. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2003
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  27. Real-Time PCR Assays for Direct Detection of Sepsis and CAP Pathogens
    Paul Keim; Fiscal Year: 2007
    ..Quantitative data will be generated with every real-time PCR assay and will analyzed together, to better understand bacterial loads in contrast to pathogens. ..
  28. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  29. Burkholderia: International Collaborative Development of Novel Diagnostics
    Paul Keim; Fiscal Year: 2007
    ....
  30. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2008
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  31. Real-Time PCR Assays for Direct Detection of Sepsis and CAP Pathogens
    Paul Keim; Fiscal Year: 2008
    ..Quantitative data will be generated with every real-time PCR assay and will analyzed together, to better understand bacterial loads in contrast to pathogens. ..
  32. Burkholderia: International Collaborative Development of Novel Diagnostics
    Paul Keim; Fiscal Year: 2008
    ....
  33. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2009
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  34. Molecular Genetics of Inattention in Australia
    RICHARD TODD; Fiscal Year: 2007
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  35. Molecular Epidemiology of Alcoholism 2- Big Sibships
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  36. Molecular Epidemiology of Alcoholism 2-Big Sibships
    RICHARD TODD; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  38. Molecular Genetics of Inattention in Australia
    RICHARD TODD; Fiscal Year: 2006
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  39. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2007
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  40. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  41. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  42. Alternative endpoints for plague challenge models
    Richard Frothingham; Fiscal Year: 2005
    ..We will use the data generated to refine our hypotheses and to pursue further funding to complete Aim 3. ..
  43. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  44. Dopamine Genotypes, Experimentally-induced Craving, & Cessation in Female Smokers
    Joel Erblich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  45. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2001
    ....
  46. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  48. Dopamine Polymorphisms and Smoking Cue-Reactivity
    Joel Erblich; Fiscal Year: 2006
    ..abstract_text> ..
  49. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2000
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  50. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2000
    ....
  51. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2001
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  52. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1990
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  53. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2000
    ....
  54. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2007
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  55. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1999
    ....
  56. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 1999
    ....
  57. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1992
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  58. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2004
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  59. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1993
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  60. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2006
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  61. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  62. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1991
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  63. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2002
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  64. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2002
    ....
  65. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  66. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2002
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  67. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2008
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  68. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
    ....
  69. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2003
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  70. Developing a Workplace Laboratory for Adults with Attention Deficit Hyperactivity
    Joseph Biederman; Fiscal Year: 2008
    ..PUBLIC HEALTH RELEVANCE: Developing a workplace laboratory for adults with ADHD is an important public health goal due to the high prevalence of occupational failure and economic burden of this population. ..
  71. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  72. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  73. Brown University Shared DNA Sequencer
    John McGeary; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  74. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  75. Molecular Genetics and Gene Expression in Psychiatric Disorders
    Ruth Kohen; Fiscal Year: 2007
    ..This will increase our understanding of genetic risk factors for mental illness, gene-environment interactions, and highlight possible new treatment strategies. ..
  76. Molecular Genetics and Gene Expression in Psychiatric Disorders
    Ruth Kohen; Fiscal Year: 2008
    ..This will increase our understanding of genetic risk factors for mental illness, gene-environment interactions, and highlight possible new treatment strategies. ..
  77. OUTCOME OF ATTENTION DEFICIT HYPERACTIVITY DISORDER
    Joseph Biederman; Fiscal Year: 2001
    ..The investigators will test three general hypotheses: prediction of outcome based on baseline ADHD (or sibling of ADHD); prediction of outcome based on comorbidity; prediction of outcome and comorbidity based on DSM-IV subtypes. ..
  78. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  79. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2000
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  80. Stress Resilience in an Animal Model of Depression
    Ruth Kohen; Fiscal Year: 2004
    ..If our hypothesis is true, it would mean a paradigm shift in our understanding of affective illness that could alter the focus of treatment from the current management of symptoms to their prevention ..