minisatellite repeats

Summary

Summary: Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit. Minisatellite repeats are often called variable number of tandem repeats.

Top Publications

  1. ncbi Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  2. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009
  3. ncbi Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
  4. ncbi EST-SSRs as a resource for population genetic analyses
    J R Ellis
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Heredity (Edinb) 99:125-32. 2007
  5. ncbi Bin mapping of genomic and EST-derived SSRs in melon (Cucumis melo L.)
    I Fernández-Silva
    IRTA, Centre de Recerca en Agrigenòmica CSIC IRTA UAB CRAG, Carretera de Cabrils, Km 2, 08348, Cabrils, Barcelona, Spain
    Theor Appl Genet 118:139-50. 2008
  6. ncbi Characterization of the soybean genome using EST-derived microsatellite markers
    Hiroshi Hisano
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 14:271-81. 2007
  7. ncbi Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China
    Wei Wei Jiao
    Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    J Clin Microbiol 46:1045-9. 2008
  8. ncbi Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
    Ronghuan Wang
    Institute of Crop Science, Chinese Academy of Agricultural Sciences National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI, 100081 Beijing, People s Republic of China
    Theor Appl Genet 117:1141-53. 2008
  9. ncbi Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
  10. ncbi An interspecific linkage map of SSR and intronic polymorphism markers in tomato
    Kenta Shirasawa
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba, 292 0818, Japan
    Theor Appl Genet 121:731-9. 2010

Research Grants

  1. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
  2. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
  3. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2005
  4. Epidemiological Investigations of ADHD
    RICHARD TODD; Fiscal Year: 2004
  5. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
  6. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2000
  7. Real-Time PCR Assays for Direct Detection of Sepsis and CAP Pathogens
    Paul Keim; Fiscal Year: 2007
  8. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
  9. Burkholderia: International Collaborative Development of Novel Diagnostics
    Paul Keim; Fiscal Year: 2007
  10. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2009

Detail Information

Publications190 found, 100 shown here

  1. ncbi Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  2. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009
    ..Moreover, among eight dicot species used for comparison purposes, carrot BES had highest homology to protein-coding sequences from tomato. This deep-coverage library will aid carrot breeding and genetics...
  3. ncbi Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
    ..The combined set of genetic markers and their integration into an improved genetic map should facilitate chickpea genetics and breeding, as well as translational studies between chickpea and Medicago...
  4. ncbi EST-SSRs as a resource for population genetic analyses
    J R Ellis
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Heredity (Edinb) 99:125-32. 2007
    ..We then discuss the advantages and disadvantages of EST-SSRs in the context of population genetic applications...
  5. ncbi Bin mapping of genomic and EST-derived SSRs in melon (Cucumis melo L.)
    I Fernández-Silva
    IRTA, Centre de Recerca en Agrigenòmica CSIC IRTA UAB CRAG, Carretera de Cabrils, Km 2, 08348, Cabrils, Barcelona, Spain
    Theor Appl Genet 118:139-50. 2008
    ..A final bin-map was constructed including 80 RFLPs, 212 SSRs, 3 SNPs and the Nsv locus, distributed in 122 bins with an average bin length of 10.2 cM and a maximum bin length of 33 cM. Map density was 4.2 cM/marker or 5.9 cM/SSR...
  6. ncbi Characterization of the soybean genome using EST-derived microsatellite markers
    Hiroshi Hisano
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 14:271-81. 2007
    ....
  7. ncbi Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China
    Wei Wei Jiao
    Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    J Clin Microbiol 46:1045-9. 2008
    ..tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required...
  8. ncbi Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
    Ronghuan Wang
    Institute of Crop Science, Chinese Academy of Agricultural Sciences National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI, 100081 Beijing, People s Republic of China
    Theor Appl Genet 117:1141-53. 2008
    ..75-40.28% in the subgroups. Among factors influencing LD, linkage was the major cause for LD of SSR loci. The results suggested that the population may be used in the detection of genome-wide SSR marker-phenotype association...
  9. ncbi Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  10. ncbi An interspecific linkage map of SSR and intronic polymorphism markers in tomato
    Kenta Shirasawa
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba, 292 0818, Japan
    Theor Appl Genet 121:731-9. 2010
    ..Information on the DNA markers developed in this study is available at http://www.kazusa.or.jp/tomato/...
  11. ncbi A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis
    Ik Young Choi
    Soybean Genomics and Improvement Laboratory, USDA, ARS, Beltsville, Maryland 20705, USA
    Genetics 176:685-96. 2007
    ....
  12. ncbi Construction of BAC and BIBAC libraries and their applications for generation of SSR markers for genome analysis of chickpea, Cicer arietinum L
    J Lichtenzveig
    Institute of Plant Science and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, 76100, Israel
    Theor Appl Genet 110:492-510. 2005
    ..The BAC and BIBAC libraries and new SSR markers will provide valuable resources for chickpea genomics research and breeding (the libraries and their filters are available to the public at http://hbz.tamu.edu)...
  13. ncbi Sequencing Medicago truncatula expressed sequenced tags using 454 Life Sciences technology
    Foo Cheung
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    BMC Genomics 7:272. 2006
    ....
  14. ncbi Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
    J Clin Microbiol 39:3563-71. 2001
    ..tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen...
  15. ncbi Different Mycobacterium avium subsp. paratuberculosis MIRU-VNTR patterns coexist within cattle herds
    K J E van Hulzen
    Department of Farm Animal Health, Utrecht University, PO Box 80 151, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 148:419-24. 2011
    ..These data indicate that such multiple genotypes of MAP can coexist within one herd...
  16. ncbi Mycobacterial interspersed repetitive units (MIRU) differentiate Mycobacterium avium subspecies paratuberculosis from other species of the Mycobacterium avium complex
    T J Bull
    Department of Surgery, St George s Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Mol Cell Probes 17:157-64. 2003
    ..avium complex (MAC) tested. PCR at both loci 1 and 4 also distinguished MAP from Mycobacterium intracellulare. MIRU typing may provide an additional simple and rapid procedure for the differentiation between MAP and other MAC...
  17. ncbi Family-based and case-control association studies of DRD4 and DAT1 polymorphisms in Chinese attention deficit hyperactivity disorder patients suggest long repeats contribute to genetic risk for the disorder
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing 100 083, China
    Am J Med Genet B Neuropsychiatr Genet 128:84-9. 2004
    ..An exploratory stratification by gender suggests that long-repeat alleles of DRD4 and DAT1 may increase the risk for ADHD in Han Chinese children...
  18. ncbi A consensus linkage map identifies genomic regions controlling fruit maturity and beta-carotene-associated flesh color in melon (Cucumis melo L.)
    H E Cuevas
    Department of Plant Breeding and Plant Genetics, University of Wisconsin Madison, Madison, WI, USA
    Theor Appl Genet 119:741-56. 2009
    ....
  19. ncbi D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
    J Gelernter
    Psychiatry 116A2, VA Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    Am J Hum Genet 61:1144-52. 1997
    ..We conclude that the most likely explanation of these results is that the DRD4 VNTR does not influence directly the trait of novelty seeking, in these samples...
  20. ncbi Genetic structure and differentiation of Oryza sativa L. in China revealed by microsatellites
    Dongling Zhang
    Key Laboratory of Crop Genomics and Genetic Improvement of Ministry of Agriculture, and Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, People s Republic of China
    Theor Appl Genet 119:1105-17. 2009
    ..Allele size was also negatively correlated with latitude and altitude, and this may be interpreted by different mutation rates, selection pressures, and population size effects under different environments and cropping systems...
  21. ncbi Development of SSR markers derived from SSR-enriched genomic library of eggplant (Solanum melongena L.)
    Tsukasa Nunome
    National Institute of Vegetable and Tea Science NIVTS, National Agriculture and Food Research Organization NARO, 360 Kusawa, Ano, Tsu, Mie 514 2392, Japan
    Theor Appl Genet 119:1143-53. 2009
    ..The linkage map spans a total length of 959.1 cM, with an average marker distance of 4.3 cM. The markers should be a useful resource for qualitative and quantitative trait mapping and for marker-assisted selection in eggplant breeding...
  22. ncbi MAOA gene polymorphisms and response to mirtazapine in major depression
    Dong Sheng Tzeng
    Department of Psychiatry, Military Kaohsiung General Hospital, Kaohsiung, Taiwan
    Hum Psychopharmacol 24:293-300. 2009
    ..Polymorphisms in the monoamine oxidase A (MAOA) gene may influence treatment outcomes in major depression disorder (MDD)...
  23. ncbi MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
    Thomas Weniger
    Department of Periodontology, University Hospital Munster, Munster, Germany
    Nucleic Acids Res 38:W326-31. 2010
    ..An extensive documentation guides users through all application functions...
  24. ncbi Genetic diversity in domesticated soybean (Glycine max) and its wild progenitor (Glycine soja) for simple sequence repeat and single-nucleotide polymorphism loci
    Ying Hui Li
    The National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI Key Lab of Germplasm Utilization MOA, Institute of Crop Science, Chinese Academy of Agricultural Sciences, 100081 Beijing, China
    New Phytol 188:242-53. 2010
    ..soja and G. max represent distinct germplasm pools. Limited evidence of admixture was discovered between these two species. Overall, our analyses are consistent with the origin of G. max from regions along the Yellow River of China...
  25. ncbi Molecular characterization of Mycobacterium avium subspecies paratuberculosis Types II and III isolates by a combination of MIRU-VNTR loci
    Elena Castellanos
    Centro de Vigilancia Sanitaria Veterinaria VISAVET, Universidad Complutense de Madrid, Avda Puerta de Hierro, 28040 Madrid, Spain
    Vet Microbiol 144:118-26. 2010
    ..Therefore, this MIRU-VNTR approach could be a useful sub-typing molecular tool in order to get a better sense of the epidemiology of Johne's disease...
  26. ncbi Comparative mapping of DNA sequences in rye (Secale cereale L.) in relation to the rice genome
    B Hackauf
    Julius Kühn Institute, Federal Research Institute for Cultivated Plants, Institute for Breeding Research on Agricultural Crops, Erwin Baur Str 27, 06484, Quedlinburg, Germany
    Theor Appl Genet 118:371-84. 2009
    ..Furthermore, the aligned markers provide genomic anchor points between rye and rice, enabling the identification of conserved ortholog set markers for rye. Perspectives of rice as a model for genome analysis in rye are discussed...
  27. ncbi Evaluation of the epidemiologic utility of secondary typing methods for differentiation of Mycobacterium tuberculosis isolates
    Awewura Kwara
    Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA
    J Clin Microbiol 41:2683-5. 2003
    ..MIRU-VNTR performed slightly better than spoligotyping in reducing the number of clustered isolates and the sizes of the clusters. All epidemiologically related isolates remained clustered by MIRU-VNTR but not by spoligotyping...
  28. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  29. ncbi High resolution, on-line identification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing
    Philippe Le Fleche
    Centre d Etudes du Bouchet BP3, 91710 Vert le Petit, France
    BMC Microbiol 2:37. 2002
    ..tuberculosis by summarising the existing data, developing additional markers, and setting up a freely accessible, fast, and easy to use, internet-based service for strain identification...
  30. ncbi A 1,000-loci transcript map of the barley genome: new anchoring points for integrative grass genomics
    Nils Stein
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, 06466, Gatersleben, Germany
    Theor Appl Genet 114:823-39. 2007
    ..It provides new anchor points for detailed studies in comparative grass genomics and will support future attempts towards the integration of genetic and physical mapping information...
  31. ncbi An optimized, multiplexed multi-locus variable-number tandem repeat analysis system for genotyping Francisella tularensis
    A J Vogler
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Lett Appl Microbiol 48:140-4. 2009
    ....
  32. ncbi A panel of microsatellite and minisatellite markers for the characterisation of field isolates of Theileria parva
    C A L Oura
    Department of Microbiology and Parasitology, Veterinary Faculty, University of Makerere, P O Box 7062, Kampala, Uganda
    Int J Parasitol 33:1641-53. 2003
    ..parva. Cluster analysis of multilocus genotypes from the 14 isolates (using a neighbour joining algorithm) revealed that genetic similarity between isolates was not obviously related to their geographical origin...
  33. ncbi Molecular characteristics of strains of the cameroon family, the major group of Mycobacterium tuberculosis in a country with a high prevalence of tuberculosis
    Sara Ngo Niobe-Eyangoh
    , Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
    J Clin Microbiol 42:5029-35. 2004
    ..The knowledge of this particular genotype, with its large involvement in tuberculosis in Cameroon, allows greater refinement of tuberculosis transmission studies by interpreting data in the context of this geographic area...
  34. ncbi Integration of simple sequence repeat (SSR) markers into a molecular linkage map of common bean (Phaseolus vulgaris L.)
    K Yu
    Agriculture and Agri Food Canada, Greenhouse and Processing Crops Research Center, Harrow, Ontario
    J Hered 91:429-34. 2000
    ..These SSR markers were stable and easy to assay by polymerase chain reaction (PCR). They should be useful markers for genetic mapping, genotype identification, and marker-assisted selection of common beans...
  35. ncbi Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, France
    Mol Microbiol 36:762-71. 2000
    ..Of the 12 variable loci, only one was found to vary among genealogically distant BCG substrains, suggesting that these interspersed bacterial minisatellite-like structures evolve slowly in mycobacterial populations...
  36. ncbi Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism
    John A Groeger
    Surrey Sleep Research Centre, Guildford, UK
    Sleep 31:1159-67. 2008
    ....
  37. ncbi Multiple locus variable number of tandem repeats analysis
    Gilles Vergnaud
    DGA D4S Mission pour la Recherche et l Innovation Scientifique MRIS, Armees, and Department of Genetics and Microbiology, University of Paris XI, Orsay, France
    Methods Mol Biol 551:141-58. 2009
    ..Finally, even if the underlying principles are relatively simple, quality standards must be implemented before this approach is widely accepted, and technology issues must be resolved to further lower the typing costs...
  38. ncbi Eucalyptus microsatellites mined in silico: survey and evaluation
    R Yasodha
    Division of Plant Biotechnology, Institute of Forest Genetics and Tree Breeding, P O Box 1061, Forest Campus, Coimbatore 641 002, India
    J Genet 87:21-5. 2008
    ..Evaluation of the usefulness of the SSRs showed that EST-derived SSRs can generate polymorphic markers as all the primers showed allelic diversity among the 16 provenances of E. tereticornis...
  39. ncbi Comparison of quantitative trait loci for adaptive traits between oak and chestnut based on an expressed sequence tag consensus map
    Manuela Casasoli
    INRA, , 33612 Cestas Cedex, France
    Genetics 172:533-46. 2006
    ..No QTL for carbon isotope discrimination was conserved between the two species. Putative candidate genes for bud burst can be identified on the basis of colocations between EST-derived markers and QTL...
  40. ncbi Organization and differential expression of the GACA/GATA tagged somatic and spermatozoal transcriptomes in Buffalo Bubalus bubalis
    Jyoti Srivastava
    Molecular Genetics Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    BMC Genomics 9:132. 2008
    ..Moreover, the distribution of GACA and GATA repeats in the prokaryotic and eukaryotic genomes was studied to highlight their significance in genome evolution...
  41. ncbi Development of a set of public SSR markers derived from genomic sequence of a rapid cycling Brassica oleracea L. genotype
    Federico L Iniguez-Luy
    Department of Agronomy, University of Wisconsin Madison, 1575 Linden Drive, Madison, WI 53706, USA
    Theor Appl Genet 117:977-85. 2008
    ..Brassica genomic DNA sequence information is a promising resource for developing a large number of SSR molecular markers in Brassica species...
  42. ncbi A new integrated genetic linkage map of the soybean
    Q J Song
    Soybean Genomics and Improvement Laboratory, USDA-ARS, Beltsville, MD 20705, USA
    Theor Appl Genet 109:122-8. 2004
    ..Development of SSR markers from map-referenced BAC clones was a very effective means of targeting markers to marker-scarce positions in the genome...
  43. ncbi Discriminatory ability of hypervariable variable number tandem repeat loci in population-based analysis of Mycobacterium tuberculosis strains, London, UK
    Preya Velji
    Barts and the London School of Medicine, Queen Mary, University of London, London, UK
    Emerg Infect Dis 15:1609-16. 2009
    ..909. Hypervariable loci should be included in standardized panels because they can provide consistent comparable results at multiple settings, provided the proposed conditions are adhered to...
  44. ncbi Molecular typing of Mycobacterium tuberculosis by using nine novel variable-number tandem repeats across the Beijing family and low-copy-number IS6110 isolates
    R Scott Spurgiesz
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011-5640, USA
    J Clin Microbiol 41:4224-30. 2003
    ..These nine loci provide a useful, discriminatory extension of VNTR typing methods for application to molecular epidemiologic studies of M. tuberculosis...
  45. ncbi A fast and cost-effective approach to develop and map EST-SSR markers: oak as a case study
    Jérôme Durand
    INRA, UMR1202 BIOGECO, F 33610 Cestas, France
    BMC Genomics 11:570. 2010
    ..We also compared the level of polymorphism between genomic and EST-derived SSRs and address the transferability of EST-SSRs in Castanea sativa (chestnut)...
  46. ncbi Fine-scale phylogeographical analysis of Mediterranean Anacamptis palustris (Orchidaceae) populations based on chloroplast minisatellite and microsatellite variation
    S Cozzolino
    Dipartimento di Biologia Vegetale, Universita degli Studi di Napoli Federico II, Via Foria, 223, I 80139 Naples, Italy
    Mol Ecol 12:2783-92. 2003
    ..Variation at the most variable minisatellite repeat type N revealed 19 alleles and allowed the study of seed-mediated gene flow and an estimation of the ratio of pollen to seed flow among neighbouring populations...
  47. ncbi Questioning INS VNTR role in obesity and diabetes: subclasses tag IGF2-INS-TH haplotypes; and -23HphI as a STEP (splicing and translational efficiency polymorphism)
    Ian N M Day
    Physiol Genomics 28:113. 2006
  48. ncbi Differentiation of tuberculosis strains in a population with mainly Beijing-family strains
    Vladyslav Nikolayevskyy
    Barts and the London School of Medicine, University of London, London, United Kingdom
    Emerg Infect Dis 12:1406-13. 2006
    ..The expanded set of 25 MIRUs provided better discrimination than the original set of 15 (Hunter-Gaston diversity index 0.870 vs. 0.625). Loci MIRU 26, 1982, and 3232 were the most polymorphic in Beijing isolates...
  49. ncbi Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s
    Leo M Schouls
    Laboratory for Vaccine Preventable Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Bacteriol 186:5496-505. 2004
    ..Using this genotyping, we have been able to show that B. pertussis is much more dynamic than expected...
  50. ncbi Microsatellite markers discriminating accessions within collections of plant genetic resources
    Jan Kraic
    Research Institute of Plant Production, Bratislavská cesta 122, 92168 Piestany, Slovakia
    Cell Mol Biol Lett 7:745-51. 2002
    ..Variation between alfalfa genotypes was not revealed at the five analyzed microsatellite loci...
  51. ncbi Standardised PCR-based molecular epidemiology of tuberculosis
    C Allix-Béguec
    Laboratoire Tuberculose et Mycobacteries, Institut Pasteur, Bruxelles Institut Scientifique de Santé Publique, Rue Engeland 642, 1180 Bruxelles, Belgium
    Eur Respir J 31:1077-84. 2008
    ..However, it will most efficiently contribute to tuberculosis control when implemented in an integrated public health system...
  52. ncbi BAC end sequences corresponding to the B4 resistance gene cluster in common bean: a resource for markers and synteny analyses
    Perrine David
    Institut de Biotechnologie des Plantes, Universite Paris Sud, 91405, Orsay, France
    Mol Genet Genomics 280:521-33. 2008
    ..Putative orthologous regions were identified on chromosome Mt6 and Lj2, in agreement with the colinearity observed between Mt and Lj for these regions...
  53. ncbi Isolation and characterization of novel microsatellite markers and their application for diversity assessment in cultivated groundnut (Arachis hypogaea)
    Luu M Cuc
    International Crop Research Institute for Semi Arid Tropics, Patancheru 502 324, Greater Hyderabad, Andhra Pradesh, India
    BMC Plant Biol 8:55. 2008
    ..The low level of polymorphism in cultivated germplasm, however, warrants a need of larger number of polymorphic microsatellite markers for cultivated groundnut...
  54. ncbi Evaluation of variable numbers of tandem repeat as molecular epidemiological markers of Mycobacterium tuberculosis in Japan
    Takayuki Wada
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Osaka 543 0026, Japan
    J Med Microbiol 56:1052-7. 2007
    ..If appropriate loci are added to the standard MIRU analysis, VNTR genotyping could be a valuable tool for strain typing and epidemiological research of M. tuberculosis in Japan...
  55. ncbi Variable-number tandem-repeat markers for typing Mycobacterium intracellulare strains isolated in humans
    Frédéric Antoine Dauchy
    Service de Maladies Infectieuses et Tropicales, Hopital Pellegrin, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    BMC Microbiol 10:93. 2010
    ..intracellulare collected in humans. We studied 61 isolates collected in humans between 2001 and 2008, as well as the reference strain, M. intracellulare ATCC 13950...
  56. ncbi Mycobacterium tuberculosis phylogeny reconstruction based on combined numerical analysis with IS1081, IS6110, VNTR, and DR-based spoligotyping suggests the existence of two new phylogeographical clades
    C Sola
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Morne Joliviere, BP 484, F 97165 Pointe à Pitre Cédex, Guadeloupe
    J Mol Evol 53:680-9. 2001
    ..In conclusion, the information contained in insertion sequence and repetitive DNAs may serve as a model for the phylogenetic reconstruction of the M. tuberculosis complex...
  57. ncbi Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036 8562 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1932-5. 2008
    ..There were no differences between other scores of TCI subscales and MAOA-VNTR polymorphism. Our results suggest a gender-specific contribution of MAOA-VNTR polymorphism to persistence scores...
  58. ncbi Human minisatellites, repeat DNA instability and meiotic recombination
    A J Jeffreys
    Department of Genetics, University of Leicester, UK
    Electrophoresis 20:1665-75. 1999
    ....
  59. ncbi No evidence of an association between a functional monoamine oxidase a gene polymorphism and completed suicides
    Hisae Ono
    Department of Psychiatry and Neurology, Kobe University School of Medicine, Kobe, Japan
    Am J Med Genet 114:340-2. 2002
    ..These results show no evidence of an association between the MAOA-uVNTR polymorphism and completed suicides and suggest that MAOA is not involved in the susceptibility to suicide...
  60. ncbi Development of variable-number tandem repeat typing of Mycobacterium bovis: comparison of results with those obtained by using existing exact tandem repeats and spoligotyping
    Solvig Roring
    Department of Veterinary Science, Queen s University Belfast, Belfast, Northern Ireland
    J Clin Microbiol 40:2126-33. 2002
    ..VNTR typing was shown to be a valuable technique with great potential for further development and application to epidemiological tracing of tuberculosis transmissions...
  61. ncbi Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR
    J Paquette
    Sainte Justine Hospital Research Center, University of Montreal, Quebec, Canada
    Genes Immun 11:590-7. 2010
    ..6-27.0), whereas having 2 short alleles conferred a 43.5-fold increased risk (95% CI 3.0-634.6). We conclude that short 5'INS VNTR class I alleles play a role in susceptibility to autoimmune diabetes in the context of APECED...
  62. ncbi Molecular characterization of Mycobacterium tuberculosis isolates from different regions of Bulgaria
    Violeta Valcheva
    Department of Pathogenic Bacteria, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    J Clin Microbiol 46:1014-8. 2008
    ..To conclude, this first study of the Bulgarian M. tuberculosis population demonstrated its heterogeneity and predominance of several worldwide-distributed and Balkan-specific spoligotypes...
  63. ncbi Association of the DAT1 polymorphism with attention deficit hyperactivity disorder (ADHD): a family-based approach
    Myung Ho Lim
    Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea
    Am J Med Genet B Neuropsychiatr Genet 141:309-11. 2006
    ..001; OR = 7.88, CI = 2.20-28.29). These data support the role of DAT1 in ADHD susceptibility among Asian populations...
  64. ncbi Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics
    Krishna Yanamandra
    Department of Pediatrics, LSU Health Sciences Center, Shreveport, LA 71130, USA
    Biochem Biophys Res Commun 335:545-9. 2005
    ..The novel allele which we termed the c allele, could be a significant risk factor in the etiology of asthma in Caucasians. This novel allele could be involved in higher levels of NO in our Caucasian asthmatics...
  65. ncbi Interleukin-1 receptor antagonist gene polymorphism in human colorectal cancer
    Hung Trinh Viet
    Center of Biotechnology, Vietnam National University, Hanoi, Vietnam
    Oncol Rep 14:915-8. 2005
    ..035). These findings therefore suggest that the IL-1Ra polymorphism is associated with colorectal carcinogenesis...
  66. ncbi Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder
    Michelle S Mazei-Robison
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 8548, USA
    Neuropharmacology 49:724-36. 2005
    ..Interestingly, the A559V variant was previously identified in a subject with bipolar disorder [. Molecular Psychiatry 5, 275], a psychiatric disorder that has a significant number of overlapping symptoms with ADHD...
  67. ncbi MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence
    Verônica Contini
    Department of Genetics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Am J Med Genet B Neuropsychiatr Genet 141:305-8. 2006
    ..These findings in a different culture further support the influence of the MAOA-uVNTR in psychiatric disorders...
  68. ncbi Association study of a functional MAOA-uVNTR gene polymorphism and personality traits in Chinese young females
    Younger W Y Yu
    Yu s Psychiatric Clinic, Kaohsiung, Taiwan
    Neuropsychobiology 52:118-21. 2005
    ..These results suggest that genetic variants of the MAOA gene may play a role in HA, but not in Novelty Seeking or Reward Dependence...
  69. ncbi Polymorphisms in the CETP gene and association with CETP mass and HDL levels
    John F Thompson
    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Atherosclerosis 167:195-204. 2003
    ..The ethnic diversity of some SNPs and complex interplay among them dictate careful analysis of the whole gene prior to conclusions about the role of individual polymorphisms...
  70. ncbi Evaluation and selection of tandem repeat loci for a Brucella MLVA typing assay
    Philippe Le Fleche
    Centre d Etudes du Bouchet BP3, 91710 Vert le Petit, France
    BMC Microbiol 6:9. 2006
    ..More efficient DNA-based methods are needed, and this work explores the suitability of multiple locus variable number tandem repeats analysis (MLVA) for both typing and species identification...
  71. ncbi A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample
    Camila Guindalini
    Medical Research Council Social Genetic and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 103:4552-7. 2006
    ..This study suggests that DAT1 gene variation may play a role in cocaine dependence etiology...
  72. ncbi A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment
    J Kirchheiner
    Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Ulm, Germany
    Pharmacogenomics J 7:48-55. 2007
    ..6 (95% CI 0.8-3.2) and carriers of the 9/9 genotype had an OR of 6.0 (1.5-24.4) for no or poor response. Further studies are required to confirm this clinical association and to elucidate the underlying mechanisms...
  73. ncbi Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    James M Swanson
    Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    J Child Adolesc Psychopharmacol 17:635-46. 2007
    ....
  74. ncbi Dominance and parent-of-origin effects of coding and non-coding alleles at the acylCoA-diacylglycerol-acyltransferase (DGAT1) gene on milk production traits in German Holstein cows
    Christa Kuehn
    Research Unit Molecular Biology, Research Institute for the Biology of Farm Animals FBN, 18196 Dummerstorf, Germany
    BMC Genet 8:62. 2007
    ..However, these data sets prevented analyses with respect to dominance or parent-of-origin effects, although an increasing number of reports in the literature outlined the relevance of non-additive gene effects on quantitative traits...
  75. ncbi Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?
    Nicolas Ballon
    Department of Psychiatry, University Hospital of Fort de France, Fort de France, Martinique, French West Indies
    Am J Med Genet B Neuropsychiatr Genet 144:1034-41. 2007
    ..Therefore, our results suggest that the clinical dimensions of childhood ADHD and of impulsivity could be taken into account to homogenize the samples of patients in cocaine association studies...
  76. ncbi A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females
    Kotoko Kosuge
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Ooyaguchi Kamimachi, Itabashi ku, Tokyo, Japan
    Int J Med Sci 4:146-52. 2007
    ..The present study identified variants in the 5'-flanking region of natriuretic peptide precursor B (NPPB) gene and assessed the relationship between gene variants and EH...
  77. ncbi Proinflammatory cytokine gene polymorphisms among Hashimoto's thyroiditis patients
    Rong Hsing Chen
    Department of Medicine, China Medical University Hospital, China Medical University, China
    J Clin Lab Anal 20:260-5. 2006
    ..In conclusion, we suggest that an IL-6 gene promoter (-572) C/G polymorphism could represent a potential "candidate" genetic marker to predict an individual's susceptibility to HT...
  78. ncbi Is MUC1 polymorphism associated with female infertility?
    L R Goulart
    Institute of Genetics and Biochemistry, Universidade Federal de Uberlandia, Uberlandia, MG Brazil
    Reprod Biomed Online 8:477-82. 2004
    ..It is suggested that other regulatory molecules and signals may interact with the MUC1 gene variations, favouring endometrial receptivity and embryo attachment...
  79. ncbi [Association between endothelial nitric oxide synthase gene 4a/b polymorphism and IgA nephropathy]
    Quan Hong
    Kidney Center and Key Laboratory of PLA, General Hospital of PLA, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1421-2, 1430. 2006
    ..To investigate the relation between endothelial nitric oxide synthase (eNOS) gene polymorphism and IgA nephropathy (IgAN)...
  80. ncbi Increased prevalence of VNTR III of the insulin gene in women with gestational diabetes mellitus (GDM)
    Hariklia Litou
    Endocrine Unit, Evgenideion Hospital, Department of Clinical Therapeutics, Alexandra University Hospital, 115 28 Athens, Greece
    Diabetes Res Clin Pract 76:223-8. 2007
    ..The aim of the study was to examine the distribution of the INS-VNTRs in women with GDM and to investigate possible associations with features of beta cell function and glycaemic control in this population...
  81. ncbi Serotonin transporter genotype and acute subjective response to amphetamine
    David C Lott
    Linden Oaks Hospital at Edward, Naperville, Illinois, USA
    Am J Addict 15:327-35. 2006
    ..The separate and combined analyses of the gene-linked polymorphic region (5-HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d-amphetamine with a small effect...
  82. ncbi Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects
    Jun Li
    Institute of Mental Health, Peking University, Peking University Sixth Hospital, Beijing, PR China
    Am J Med Genet B Neuropsychiatr Genet 144:14-9. 2007
    ..751, P = 0.016) to probands with ADHD. Haplotype analysis found the L/10 haplotype was over-transmitted (chi(2) = 6.172, P = 0.013), while L/12 was under-transmitted to probands with ADHD (chi(2) = 4.866, P = 0.027)...
  83. ncbi Association between achalasia and nitric oxide synthase gene polymorphisms
    Fermin Mearin
    Institute of Functional and Motor Digestive Disorders, Centro Medico Teknon, Barcelona, Spain
    Am J Gastroenterol 101:1979-84. 2006
    ..NOS exists in three distinct isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible isoform (iNOS). Some studies have shown that NO production is regulated by NOS polymorphisms...
  84. ncbi Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population
    Evica Dincic
    Department of Neurology, Military Medical Academy, Belgrade, Serbia and Montenegro
    J Neuroimmunol 177:146-50. 2006
    ..4, CI = 2.0-9.7, p = 0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations...
  85. ncbi An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood
    Russell A Barkley
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 141:487-98. 2006
    ..We also present a contrary view on the appropriate endophenotypes for use in behavioral genetic research on ADHD...
  86. ncbi Preliminary evidence that specific candidate genes are associated with adolescent-onset antisocial behavior
    S Alexandra Burt
    Department of Psychology, Michigan State University, East Lansing, Michigan 48824, USA
    Aggress Behav 34:437-45. 2008
    ..They also offer preliminary evidence that the genetic processes underlying aggressive and nonaggressive antisocial behavior may be (at least partially) distinct...
  87. ncbi Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel
    J Di Paola
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Thromb Haemost 3:1511-21. 2005
    ..These data provide a valuable resource for optimal selection of variants best tailored for association studies of vascular disease or bleeding disorders when examining individuals of different ancestral origins...
  88. ncbi Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension
    A V Benjafield
    Department of Physiology and Institute for Biomedical Research, The University of Sydney, New South Wales, Australia
    Am J Hypertens 13:994-8. 2000
    ..However, possible genotypic effects on plasma lipids and body mass index might warrant further studies, especially in view of possible associations with heart disease...
  89. ncbi Microsatellite marker analysis of an anther-derived potato family: skewed segregation and gene-centromere mapping
    Eduard Chani
    Department of Horticulture, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Genome 45:236-42. 2002
    ..The majority of the SSR loci mapped more than 33 cM from the centromere, suggesting the occurrence of a single crossover per chromosome arm...
  90. ncbi Schizophrenia and functional polymorphisms in the MAOA and COMT genes: no evidence for association or epistasis
    Nadine Norton
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
    Am J Med Genet 114:491-6. 2002
    ..Our data, therefore, do not support the hypothesis that genetic variation in MAOA and COMT is involved individually or in combination in the etiology of schizophrenia...
  91. ncbi IL-1B and IL-6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS)
    M R Bazrafshani
    ARC Epidemiology Unit, University of Manchester, UK
    Genes Immun 3:302-5. 2002
    ..4, P < 0.0001). IL-1RN VNTR 1/1 homozygotes also occurred more frequently in RAS (OR = 2.0, P < 0.02). Inheritance of the G/G genotype of both IL-1B and IL-6 was a particularly strong predictor for RAS (OR = 8.5)...
  92. ncbi Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease
    Clare Muckian
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Blood 100:1220-3. 2002
    ..This is the first reported association between polymorphisms of extracellular matrix components and cardiovascular risk...
  93. ncbi Genetic polymorphism study at four minisatellite loci (D1S80, D17S5, D19S20, and APOB) among five Indian population groups
    Birajalaxmi Das
    Cell Biology Division, Bhahha Atomic Research Centre, Trombay, Mumbai, India
    Hum Biol 74:345-61. 2002
    ..The results obtained are in conformity with the geographical and linguistic backgrounds of the studied populations...
  94. ncbi Mapping the Fas locus controlling stearic acid content in soybean
    M M Spencer
    The University of Tennessee, Department of Plant Sciences and Landscape Systems, 252 Ellington Plant Science Building, 2431 Center Drive, Knoxville 37996 4561, USA
    Theor Appl Genet 106:615-9. 2003
    ..0. Identification of these markers may be useful in molecular marker-assisted breeding programs targeting modifications in soybean fatty acids...
  95. ncbi Cladistic analysis of human apolipoprotein a4 polymorphisms in relation to quantitative plasma lipid risk factors of coronary heart disease
    G Q Wang
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Ann Hum Genet 67:107-24. 2003
    ..Several haplotypes were identified by cladistic analysis that may carry functional mutations that affect plasma lipid trait levels...
  96. ncbi The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients
    Juei Jueng Lin
    Department of Neurology, Chushang Show Chwan Hospital, Nantou, Taiwan, ROC
    J Neurol Sci 209:87-92. 2003
    ..02, 95% CI=0.49-2.11, p=0.966). In conclusion, the results of our study show that homozygote 10-copy genotype of the VNTR polymorphism within the DAT may confer a protective factor for male PD patients, but not for female PD patients...
  97. ncbi Association of ecNOS gene polymorphisms with end stage renal diseases
    Sohji Nagase
    Division of Nephrology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Mol Cell Biochem 244:113-8. 2003
    ..Further study is required to clarify the detailed mechanisms...
  98. ncbi [Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder]
    Yi Huang
    Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:100-3. 2002
    ..To investigate whether DRD4 exon III48 bp variant number tandem repeat(VNTR) polymorphism is associated with tic disorder...
  99. ncbi CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody
    T Abe
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Diabet Med 18:726-31. 2001
    ....
  100. ncbi Polymorphism in the interleukin-1 receptor antagonist gene is associated with alcoholism in Spanish men
    I J Pastor
    Department of Medicine, and INCYL, University of Salamanca, Spain
    Alcohol Clin Exp Res 24:1479-82. 2000
    ..In the present study, we analyzed whether there is an association between this polymorphism, alcoholism, and alcoholic liver disease in a Spanish male population of alcoholics...
  101. ncbi Serotonin transporter gene polymorphisms in alcohol dependence
    M D Thompson
    Department of Pharmacology, University of Toronto, M5S 2S1, Toronto, Ontario, Canada
    Alcohol 22:61-7. 2000
    ..The data presented suggests a trend toward increased frequency of the S promoter allele in alcohol-dependent, alcoholic-TS and TS patients...

Research Grants123 found, 100 shown here

  1. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2010
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  2. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  3. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  4. Epidemiological Investigations of ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  5. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  6. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2000
    ..Once identified, the extended families will be an important resource for future studies to identify genetic etiologies of ADHD. ..
  7. Real-Time PCR Assays for Direct Detection of Sepsis and CAP Pathogens
    Paul Keim; Fiscal Year: 2007
    ..Quantitative data will be generated with every real-time PCR assay and will analyzed together, to better understand bacterial loads in contrast to pathogens. ..
  8. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  9. Burkholderia: International Collaborative Development of Novel Diagnostics
    Paul Keim; Fiscal Year: 2007
    ....
  10. A multi-faceted approach to epigenomic profiling in Alzheimer's disorder
    Jonathan Mill; Fiscal Year: 2009
    ..This study aims to transform our understanding about the etiology of Alzheimer's disorder by uncovering evidence for epigenetic disruption in post-mortem brain tissue and peripheral cells obtained from affected individuals. ..
  11. Molecular Genetics of Inattention in Australia
    RICHARD TODD; Fiscal Year: 2007
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  12. Molecular Epidemiology of Alcoholism 2-Big Sibships
    RICHARD TODD; Fiscal Year: 2006
    ....
  13. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  14. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2007
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  15. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  16. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  17. Alternative endpoints for plague challenge models
    Richard Frothingham; Fiscal Year: 2005
    ..We will use the data generated to refine our hypotheses and to pursue further funding to complete Aim 3. ..
  18. Dopamine Genotypes, Experimentally-induced Craving, & Cessation in Female Smokers
    Joel Erblich; Fiscal Year: 2007
    ....
  19. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2007
    ....
  20. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  21. Dopamine Polymorphisms and Smoking Cue-Reactivity
    Joel Erblich; Fiscal Year: 2006
    ..abstract_text> ..
  22. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2007
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  23. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1999
    ....
  24. CHRONIC AND ACUTE TOLERANCE TO NICOTINE IN HUMANS
    Kenneth Perkins; Fiscal Year: 1993
    ..Results may proivde directions for the study of mechanisms responsible for tolerance, as well as for investigations of physiological and behavioral aspects of nicotine depenence and smoking relapse...
  25. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  26. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  27. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
    ....
  28. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  29. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2007
    ..From a public health perspective, the ability to predict the course of psychopathology in girls with ADHD could help focus limited societal resources on those at higher risk for persistent illness with complicated outcomes. ..
  30. Molecular Genetics and Gene Expression in Psychiatric Disorders
    Ruth Kohen; Fiscal Year: 2007
    ..This will increase our understanding of genetic risk factors for mental illness, gene-environment interactions, and highlight possible new treatment strategies. ..
  31. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  32. Stress Resilience in an Animal Model of Depression
    Ruth Kohen; Fiscal Year: 2004
    ..If our hypothesis is true, it would mean a paradigm shift in our understanding of affective illness that could alter the focus of treatment from the current management of symptoms to their prevention ..