minisatellite repeats

Summary

Summary: Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit. Minisatellite repeats are often called variable number of tandem repeats.

Top Publications

  1. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
  2. pmc MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
    Thomas Weniger
    Department of Periodontology, University Hospital Munster, Munster, Germany
    Nucleic Acids Res 38:W326-31. 2010
  3. ncbi Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, France
    Mol Microbiol 36:762-71. 2000
  4. pmc Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
    J Clin Microbiol 39:3563-71. 2001
  5. pmc The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
    Cyril Ribeyre
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris, France
    PLoS Genet 5:e1000475. 2009
  6. pmc Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set
    Ingrid Filliol
    Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, MSB A920C, Newark, NJ 07103
    J Bacteriol 188:759-72. 2006
  7. pmc High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology
    E Mazars
    , , U447, Institut Pasteur de Lille, rue du Prof. Calmette, F-59019 Lille Cedex, France
    Proc Natl Acad Sci U S A 98:1901-6. 2001
  8. pmc A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping
    Eve Haguenoer
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
    BMC Microbiol 11:171. 2011
  9. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
  10. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009

Detail Information

Publications281 found, 100 shown here

  1. pmc Proposal for standardization of optimized mycobacterial interspersed repetitive unit-variable-number tandem repeat typing of Mycobacterium tuberculosis
    Philip Supply
    INSERM U629, Institut Pasteur de Lille, 1, Rue du Prof Calmette, F 59019 Lille cedex, France
    J Clin Microbiol 44:4498-510. 2006
    ..This 15-locus system is therefore proposed as the new standard for routine epidemiological discrimination of M. tuberculosis isolates and the 24-locus system as a high-resolution tool for phylogenetic studies...
  2. pmc MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
    Thomas Weniger
    Department of Periodontology, University Hospital Munster, Munster, Germany
    Nucleic Acids Res 38:W326-31. 2010
    ..An extensive documentation guides users through all application functions...
  3. ncbi Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, France
    Mol Microbiol 36:762-71. 2000
    ..Of the 12 variable loci, only one was found to vary among genealogically distant BCG substrains, suggesting that these interspersed bacterial minisatellite-like structures evolve slowly in mycobacterial populations...
  4. pmc Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units
    P Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F 59019 Lille cedex, France
    J Clin Microbiol 39:3563-71. 2001
    ..tuberculosis MIRU-VNTR genotypes via the Internet. This opens the way for global epidemiological surveillance of tuberculosis and should lead to novel insights into the evolutionary and population genetics of this major pathogen...
  5. pmc The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
    Cyril Ribeyre
    Recombinaison et Instabilité Génétique, Institut Curie Centre de Recherche, CNRS UMR3244, Universite Pierre et Marie Curie, Paris, France
    PLoS Genet 5:e1000475. 2009
    ..Hence, we conclude that CEB1 instability in pif1Delta cells depends on the potential to form G-quadruplex structures, suggesting that Pif1 could play a role in the metabolism of G4-forming sequences...
  6. pmc Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set
    Ingrid Filliol
    Division of Infectious Disease, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, MSB A920C, Newark, NJ 07103
    J Bacteriol 188:759-72. 2006
    ..tuberculosis...
  7. pmc High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology
    E Mazars
    , , U447, Institut Pasteur de Lille, rue du Prof. Calmette, F-59019 Lille Cedex, France
    Proc Natl Acad Sci U S A 98:1901-6. 2001
    ..This typing method opens the way to the construction of digital global databases for molecular epidemiology studies of M. tuberculosis...
  8. pmc A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping
    Eve Haguenoer
    Universite Francois Rabelais de Tours, UFR de Medecine, EA 3854 Bactéries et risque materno fœtal, Institut Fédératif de Recherche 136 Agents Transmissibles et Infectiologie, Tours, France
    BMC Microbiol 11:171. 2011
    ..We describe here a genotyping method based on multiple locus variable number of tandem repeat (VNTR) analysis (MLVA) applied to a population of S. agalactiae strains of various origins characterized by MLST and serotyping...
  9. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
    ..The combined set of genetic markers and their integration into an improved genetic map should facilitate chickpea genetics and breeding, as well as translational studies between chickpea and Medicago...
  10. ncbi Characterization of a deep-coverage carrot (Daucus carota L.) BAC library and initial analysis of BAC-end sequences
    Pablo F Cavagnaro
    Department of Horticulture, University of Wisconsin, 1575 Linden Drive, Madison, WI 53706, USA
    Mol Genet Genomics 281:273-88. 2009
    ..Moreover, among eight dicot species used for comparison purposes, carrot BES had highest homology to protein-coding sequences from tomato. This deep-coverage library will aid carrot breeding and genetics...
  11. pmc Assessment of an optimized mycobacterial interspersed repetitive- unit-variable-number tandem-repeat typing system combined with spoligotyping for population-based molecular epidemiology studies of tuberculosis
    Mara Cardoso Oelemann
    INSERM, U629, Institut Pasteur de Lille, Lille, France
    J Clin Microbiol 45:691-7. 2007
    ..tuberculosis transmission...
  12. ncbi PER3 polymorphism predicts sleep structure and waking performance
    Antoine U Viola
    Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Curr Biol 17:613-8. 2007
    ..The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis...
  13. ncbi Medicago truncatula EST-SSRs reveal cross-species genetic markers for Medicago spp
    I Eujayl
    The Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Theor Appl Genet 108:414-22. 2004
    ..truncatula ESTs are valuable genetic markers for the Medicago genus. These markers will be useful in establishing the genomic relationships of M. truncatula to important forage legume crops such as alfalfa and other annual medics...
  14. pmc Three-year population-based evaluation of standardized mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing of Mycobacterium tuberculosis
    Caroline Allix-Béguec
    Molecular Mechanisms of Bacterial Pathogenesis, INSERM U629, Institut de Biologie de Lille Institut Pasteur de Lille, 1 rue du Professeur Calmette, F 59021 Lille cedex, France
    J Clin Microbiol 46:1398-406. 2008
    ..g., large sequence polymorphisms. Our results reinforce the proposal of standardized MIRU-VNTR typing as a new reference genotyping method for the epidemiological and phylogenetic screening of M. tuberculosis strains...
  15. pmc Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei
    Horng Yunn Dou
    Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    BMC Infect Dis 8:170. 2008
    ..Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture...
  16. ncbi The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
    S Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan
    Pharmacogenomics J 1:152-6. 2001
    ..This suggests that VNTR polymorphism affects the expression of the dopamine transporter...
  17. pmc Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat an
    George Killgore
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 46:431-7. 2008
    ..All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks...
  18. pmc Characterization of the soybean genome using EST-derived microsatellite markers
    Hiroshi Hisano
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 14:271-81. 2007
    ....
  19. pmc Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis
    Erin P Price
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
    PLoS Pathog 6:e1000725. 2010
    ....
  20. pmc Isolation and characterization of novel microsatellite markers and their application for diversity assessment in cultivated groundnut (Arachis hypogaea)
    Luu M Cuc
    International Crop Research Institute for Semi Arid Tropics, Patancheru 502 324, Greater Hyderabad, Andhra Pradesh, India
    BMC Plant Biol 8:55. 2008
    ..The low level of polymorphism in cultivated germplasm, however, warrants a need of larger number of polymorphic microsatellite markers for cultivated groundnut...
  21. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  22. pmc A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample
    Camila Guindalini
    Medical Research Council Social Genetic and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 103:4552-7. 2006
    ..This study suggests that DAT1 gene variation may play a role in cocaine dependence etiology...
  23. pmc Evaluation of a multilocus variable-number tandem-repeat analysis scheme for typing human Brucella isolates in a region of brucellosis endemicity
    Mireille M Kattar
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    J Clin Microbiol 46:3935-40. 2008
    ..melitensis isolates, and inferring their geographical origin. Abbreviated panel 2B could be used as a short-term epidemiological tool in a small region of endemicity...
  24. ncbi DRD4 and novelty seeking: results of meta-analyses
    J A Schinka
    James A Haley Veteran Administration Medical Center, Tampa, Florida 33612, USA
    Am J Med Genet 114:643-8. 2002
    ..32. The positive findings are consistent with a polygenic model of influence on fundamental personality dimensions...
  25. ncbi Role of genotype in the cycle of violence in maltreated children
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London SE5 8AF, UK
    Science 297:851-4. 2002
    ..These findings may partly explain why not all victims of maltreatment grow up to victimize others, and they provide epidemiological evidence that genotypes can moderate children's sensitivity to environmental insults...
  26. ncbi Genetic diversity of the Mycobacterium tuberculosis Beijing family in East Asia revealed through refined population structure analysis
    Takayuki Wada
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan
    FEMS Microbiol Lett 291:35-43. 2009
    ..Our results reflect the singular genetic diversity and the epidemiological pattern of Beijing M. tuberculosis in Japan...
  27. pmc Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF
    Fahad R Ali
    School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Neurochem 112:296-306. 2010
    ..We suggest that the potential for interaction between multiple polymorphic domains should be incorporated into genetic association studies...
  28. pmc Evaluation of new variable-number tandem-repeat systems for typing Mycobacterium tuberculosis with Beijing genotype isolates from Beijing, China
    Wei Wei Jiao
    Public Central Laboratory, Beijing Pediatric Research Institute, Beijing Children s Hospital Affiliated to Capital Medical University, Beijing 100045, China
    J Clin Microbiol 46:1045-9. 2008
    ..tuberculosis isolates in Beijing, while secondary typing of clustered strains by IS6110-RFLP is still required...
  29. ncbi Development of chickpea EST-SSR markers and analysis of allelic variation across related species
    Shalu Choudhary
    National Institute of Plant Genome Research, Post Box Number 10531, Aruna Asaf Ali Marg, Jawaharlal Nehru University Campus, New Delhi, 110067, India
    Theor Appl Genet 118:591-608. 2009
    ....
  30. ncbi Bin mapping of genomic and EST-derived SSRs in melon (Cucumis melo L.)
    I Fernández-Silva
    IRTA, Centre de Recerca en Agrigenòmica CSIC IRTA UAB CRAG, Carretera de Cabrils, Km 2, 08348, Cabrils, Barcelona, Spain
    Theor Appl Genet 118:139-50. 2008
    ..A final bin-map was constructed including 80 RFLPs, 212 SSRs, 3 SNPs and the Nsv locus, distributed in 122 bins with an average bin length of 10.2 cM and a maximum bin length of 33 cM. Map density was 4.2 cM/marker or 5.9 cM/SSR...
  31. pmc Phylogeography and molecular epidemiology of Yersinia pestis in Madagascar
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1319. 2011
    ..pestis in Madagascar...
  32. ncbi Establishment of a genotyping scheme for Coxiella burnetii
    Sanela Svraka
    Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    FEMS Microbiol Lett 254:268-74. 2006
    ..The selected VNTR markers were stable. The MLVA method developed in this report is a promising tool for the characterization of C. burnetii isolates and their epidemiological study...
  33. pmc Evaluation of high-resolution typing methods for Chlamydia trachomatis in samples from heterosexual couples
    Reinier J M Bom
    Public Health Laboratory, Public Health Service of Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands
    J Clin Microbiol 49:2844-53. 2011
    ..This shows that the chlamydial genome in clinical specimens has an appropriate polymorphism to enable epidemiological cluster analysis using MLST and MLVA...
  34. pmc Genetic diversity of Mycobacterium tuberculosis isolates from a tertiary care tuberculosis hospital in South Korea
    Isdore Chola Shamputa
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Microbiol 48:387-94. 2010
    ..tuberculosis Beijing strains. Within the study limits, our results also suggest that the problem of drug-resistant TB in the Republic of Korea may be largely due to acquired resistance as opposed to transmission...
  35. ncbi Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay
    Bjørn Arne Lindstedt
    Norwegian Institute of Public Health, Division for Infectious Diseases Control, N 0403 Oslo, Norway
    J Microbiol Methods 69:197-205. 2007
    ..Shigella isolates were of species S. flexneri, S. boydii, S. sonnei and S. dysenteriae. The MLVA method rapidly genotyped all isolates in the study at a Simpson's index of diversity of D=0.98...
  36. pmc MLVA-16 typing of 295 marine mammal Brucella isolates from different animal and geographic origins identifies 7 major groups within Brucella ceti and Brucella pinnipedialis
    Marianne Maquart
    INRA, UR1282, Infectiologie Animale et Sante Publique, IASP, Nouzilly, F 37380, France
    BMC Microbiol 9:145. 2009
    ..A previously published assay comprising 16 loci (MLVA-16) that has been shown to be highly relevant and efficient for typing and clustering Brucella strains from animal and human origin was used...
  37. ncbi Variable-number tandem repeats typing of Mycobacterium tuberculosis isolates with low copy numbers of IS6110 in Thailand
    Arunee Thong-On
    Department of Microbiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, Thailand
    Tuberculosis (Edinb) 90:9-15. 2010
    ..4% of clustered isolates. Our results confirm the utility of VNTR typing as the secondary method of choice for investigating the epidemiology of M. tuberculosis with low copy numbers of IS6110...
  38. pmc Use of mycobacterial interspersed repetitive unit-variable-number tandem repeat typing to examine genetic diversity of Mycobacterium tuberculosis in Singapore
    Yong Jiang Sun
    Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Republic of Singapore
    J Clin Microbiol 42:1986-93. 2004
    ..These results indicate that MIRU-VNTR typing can be a useful first-line tool for studying the genetic diversity of M. tuberculosis isolates in a large urban setting such as Singapore...
  39. pmc Yersinia pestis lineages in Mongolia
    Julia M Riehm
    Bundeswehr Institute of Microbiology, Munich, Germany
    PLoS ONE 7:e30624. 2012
    ..The majority of central Asia natural foci have been investigated. However these investigations included only few strains from Mongolia...
  40. ncbi Genotyping of Mycoplasma bovis isolates using multiple-locus variable-number tandem-repeat analysis
    Luís Pinho
    ICBAS, Department of Veterinary Clinics, Instituto de Ciencias Biomedicas Abel Salazar, University of Porto, R Padre Armando Quintas, 7, 4485 661 Vairão, Vila do Conde, Portugal
    J Microbiol Methods 88:377-85. 2012
    ..The molecular typing scheme presented in this study provides a fast, reliable, and cost-effective typing method for surveillance of M. bovis epidemiology...
  41. pmc Multiple-locus variable-number tandem-repeat analysis of Streptococcus pneumoniae and comparison with multiple loci sequence typing
    Hélène Van Cuyck
    HIA Robert Picque, Villenave D Ornon, France
    BMC Microbiol 12:241. 2012
    ..pneumoniae by applying marker sets used by different authors on 331 isolates selected in UK...
  42. ncbi Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample
    Manfred Laucht
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 64:585-90. 2007
    ..Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD)...
  43. pmc Detection of multiple strains of Mycobacterium tuberculosis using MIRU-VNTR in patients with pulmonary tuberculosis in Kampala, Uganda
    Katherine R Dickman
    Department of Pediatrics, Boston Medical Center, Boston University, Boston, USA
    BMC Infect Dis 10:349. 2010
    ..We aimed to determine the prevalence of MTB multiple strain infections in Kampala, and the impact of these infections on clinical presentation of tuberculosis (TB) and response to treatment...
  44. pmc Identification of variable-number tandem-repeat (VNTR) sequences in Acinetobacter baumannii and interlaboratory validation of an optimized multiple-locus VNTR analysis typing scheme
    Christine Pourcel
    Universite Paris Sud, Institut de Genetique et Microbiologie, CNRS, Orsay F 91405, France
    J Clin Microbiol 49:539-48. 2011
    ..Typeability, reproducibility, stability, discriminatory power, and epidemiological concordance were excellent. A database containing information and MLVA profiles for several A. baumannii strains is available from http://mlva.u-psud.fr/...
  45. ncbi Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers
    Wei Yen Lim
    Department of Epidemiology and Public Health National University of Singapore, and Department of Pathology, Tan Tock Seng Hospital, Singapore, Singapore
    Carcinogenesis 32:522-9. 2011
    ..47). Our results suggest that the effect of inflammatory medical conditions on lung cancer in never-smokers is modulated by host genetic susceptibility and will need to be confirmed in other studies conducted in similar populations...
  46. ncbi Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    J C Machado
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Gastroenterology 121:823-9. 2001
    ....
  47. ncbi Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects
    Xavier Caldu
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, and Department of Radiology, Centre de Diagnòstic per la Image, Hospital Clinic de Barcelona, Spain
    Neuroimage 37:1437-44. 2007
    ..The 10-repeat allele was associated with faster reaction times but also with a higher number of commission errors. Our results support a role of the COMT Val108/158 Met and the DAT 40 bp VNTR in both brain activation and cognition...
  48. pmc MLVA genotyping of Chinese human Brucella melitensis biovar 1, 2 and 3 isolates
    Hai Jiang
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 155 Changbai Road, Changping, Beijing 102206, PR China
    BMC Microbiol 11:256. 2011
    ..melitensis isolates from China using a multiple-locus variable-number tandem-repeat analysis (MLVA) and evaluated the utility of MLVA with regards to epidemiological trace-back investigation...
  49. pmc Bacillus anthracis diversity in Kruger National Park
    K L Smith
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona 86011 5640, USA
    J Clin Microbiol 38:3780-4. 2000
    ..While this association may be simply fortuitous, adaptation of A types to diverse environmental conditions is consistent with their greater geographic dispersal and genetic dissimilarity...
  50. pmc Housekeeping gene sequencing and multilocus variable-number tandem-repeat analysis to identify subpopulations within Pseudomonas syringae pv. maculicola and Pseudomonas syringae pv. tomato that correlate with host specificity
    S Gironde
    INRA, UMR 1345 Institut de Recherche en Horticulture et Semences IRHS, INRA, Agrocampus Ouest, Universite d Angers, Beaucouze, France
    Appl Environ Microbiol 78:3266-79. 2012
    ..tomato appear multiclonal, as they did not diverge from a single common ancestral group within the ancestral P. syringae genomospecies 3, and suggests that pathovar specificity within P. syringae may be due to independent genetic events...
  51. ncbi Genetic diversity in domesticated soybean (Glycine max) and its wild progenitor (Glycine soja) for simple sequence repeat and single-nucleotide polymorphism loci
    Ying Hui Li
    The National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI Key Lab of Germplasm Utilization MOA, Institute of Crop Science, Chinese Academy of Agricultural Sciences, 100081 Beijing, China
    New Phytol 188:242-53. 2010
    ..soja and G. max represent distinct germplasm pools. Limited evidence of admixture was discovered between these two species. Overall, our analyses are consistent with the origin of G. max from regions along the Yellow River of China...
  52. pmc Determination of genotypic diversity of Mycobacterium avium subspecies from human and animal origins by mycobacterial interspersed repetitive-unit-variable-number tandem-repeat and IS1311 restriction fragment length polymorphism typing methods
    Nicolas Radomski
    Unité Zoonoses Bactériennes, LERPAZ, AFSSA, 23 Avenue du Général de Gaulle, Maisons Alfort F 94706 Cedex, France
    J Clin Microbiol 48:1026-34. 2010
    ..MIRU-VNTR typing therefore appears to be a convenient typing method capable of distinguishing the three main subspecies and strains of the complex and providing new epidemiological knowledge on MAC...
  53. pmc Association of relapse of Clostridium difficile disease with BI/NAP1/027
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 50:4078-82. 2012
    ..Classification of recurrent CDI episodes by MLVA can be utilized to make informed patient care decisions and to accurately define new CDI cases for infection control and reimbursement purposes...
  54. pmc Differentiation of strains of Xylella fastidiosa by a variable number of tandem repeat analysis
    H D Coletta-Filho
    Centro de Citricultura Sylvio Moreira, INSTITUTO AGRONOMICO, CEP 13490 970, Cordeiropolis, Sao Paulo, Brazil
    Appl Environ Microbiol 67:4091-5. 2001
    ..83, while the maximum value given by specific RAPD loci was 0.12. Our approach using VNTR markers provides a high-resolution tool for epidemiological, genetic, and ecological analysis of citrus-specific X. fastidiosa strains...
  55. ncbi Utility of fast mycobacterial interspersed repetitive unit-variable number tandem repeat genotyping in clinical mycobacteriological analysis
    Caroline Allix
    Institut Pasteur de Bruxelles, Laboratoire Tuberculose et Mycobacteries, Brussels, Belgium
    Clin Infect Dis 39:783-9. 2004
    ..We describe its application to 3 typical clinical situations encountered in our laboratory (Institut Pasteur de Bruxelles, Laboratoire Tuberculose et Mycobacteries; Brussels, Belgium)...
  56. pmc Epidemiological and phylogenetic analysis of Spanish human Brucella melitensis strains by multiple-locus variable-number tandem-repeat typing, hypervariable octameric oligonucleotide fingerprinting, and rpoB typing
    Sylvia Valdezate
    Servicio de Bacteriología Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Clin Microbiol 48:2734-40. 2010
    ....
  57. ncbi A framework linkage map of perennial ryegrass based on SSR markers
    G P Gill
    ViaLactia Biosciences, PO Box 109 185, Newmarket, Auckland, New Zealand
    Genome 49:354-64. 2006
    ..The final map provides a robust framework with which to conduct investigations into the genetic architecture of trait variation in this commercially important grass species...
  58. pmc Molecular typing of Mycobacterium abscessus based on tandem-repeat polymorphism
    Y L Wong
    Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
    J Clin Microbiol 50:3084-8. 2012
    ..9563) that is superior to that of multilocus sequencing. It is a promising tool for the investigation of Mycobacterium abscessus epidemiology and nosocomial outbreaks...
  59. ncbi A comparison of simple sequence repeat and single nucleotide polymorphism marker technologies for the genotypic analysis of maize (Zea mays L.)
    E S Jones
    Pioneer Hi Bred International Inc DuPont Agriculture and Nutrition, 7300 NW 62nd Avenue, Johnston, IA 51031 1004, USA
    Theor Appl Genet 115:361-71. 2007
    ....
  60. pmc Multiple-locus variable-number tandem-repeat analysis is a suitable tool for differentiation of Mycoplasma hyopneumoniae strains without cultivation
    K Vranckx
    Department of Pathology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    J Clin Microbiol 49:2020-3. 2011
    ..The test had a discriminatory index of >0.99 and was applied reliably to porcine bronchoalveolar lavage fluid and tracheal swabs...
  61. pmc High throughput multiple locus variable number of tandem repeat analysis (MLVA) of Staphylococcus aureus from human, animal and food sources
    Daniel Sobral
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR 8621, Orsay, France
    PLoS ONE 7:e33967. 2012
    ..Interestingly, isolates responsible for food poisoning show a CC distribution signature typical of human isolates and strikingly different from animal isolates, suggesting a predominantly human origin...
  62. ncbi Rapid and high resolution genotyping of all Escherichia coli serotypes using 10 genomic repeat-containing loci
    Inger Løbersli
    Division of Infectious Diseases Control, Norwegian Institute of Public Health, Lovisenberggata 8, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    J Microbiol Methods 88:134-9. 2012
    ..The GECM7 method was improved by adding three new repeat-loci to a total of ten (GECM10), and a considerable increase in resolution was observed (from 296 to 507 genotypes on the same set of strains)...
  63. ncbi A composite linkage map from two crosses for the species complex Picea mariana x Picea rubens and analysis of synteny with other Pinaceae
    Betty Pelgas
    Chaire de recherche du Canada en génomique forestière et environnementale, Centre de recherche en biologie forestière, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, QC, G1K 7P4, Canada
    Theor Appl Genet 111:1466-88. 2005
    ..Implications for the evolution of the Pinaceae genome are discussed...
  64. ncbi Genetic variability and genetic structure of wild and semi-domestic populations of tasar silkworm (Antheraea mylitta ) ecorace Daba as revealed through ISSR markers
    P K Kar
    Central Sericultural Germplasm Resources Centre, Central Silk Board, Thally Road, P B 44635109 Hosur, Tamil Nadu, India
    Genetica 125:173-83. 2005
    ..The high genetic variability present within wild Daba population of A. mylitta is of much importance for conservation as well as utilization in systematic breeding program...
  65. ncbi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida, USA
    Nat Genet 15:293-7. 1997
    ..Higher levels of (pro)insulin in the thymus may promote negative selection (deletion) of insulin-specific T-lymphocytes which play a critical role in the pathogenesis of type-1 diabetes...
  66. ncbi Mutation rates of spoligotypes and variable numbers of tandem repeat loci in Mycobacterium tuberculosis
    Josephine F Reyes
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Infect Genet Evol 10:1046-51. 2010
    ..These findings confirm the high level of discrimination observed using multilocus VNTR typing, and suggest that caution should be taken not to underestimate the extent of recent transmission when using this marker...
  67. pmc Investigation on Mycobacterium tuberculosis diversity in China and the origin of the Beijing clade
    Kanglin Wan
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR 8621, Orsay, France
    PLoS ONE 6:e29190. 2011
    ..In order to examine the strain diversity in the whole country, and to study the evolutionary development of Beijing strains, we sought to genotype a large collection of isolates using different methods...
  68. ncbi Culture-independent multi-locus variable-number tandem-repeat analysis (MLVA) of Mycoplasma pneumoniae
    Roger Dumke
    Dresden University of Technology, Medical Faculty Carl Gustav Carus, Institute of Medical Microbiology and Hygiene, Fetscherstrasse 74, d, 01307 Dresden, Germany
    J Microbiol Methods 86:393-6. 2011
    ..pneumoniae-positive pneumonia patients. The method resulted in a clearly identifiable MLVA type in all samples tested and can be used for MLVA without laborious isolation of the pathogen...
  69. ncbi Impact of homoplasy on variable numbers of tandem repeats and spoligotypes in Mycobacterium tuberculosis
    Josephine F Reyes
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Infect Genet Evol 12:811-8. 2012
    ..However, deep phylogenetic inferences using spoligotypes or VNTRs with a small number of loci are likely to be unreliable...
  70. ncbi Mathematical modelling of Mycobacterium tuberculosis VNTR loci estimates a very slow mutation rate for the repeats
    Andrew Grant
    Statistics Unit, Statistics, Modelling and Bioinformatics Department, Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Mol Evol 66:565-74. 2008
    ..This suggests that the VNTR profile of a strain of M. tuberculosis will be indicative of its clonal lineage and will be unlikely to vary in epidemiologically-related strains...
  71. pmc Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
    Ingrid Olsen
    Centre for Molecular Biology and Neuroscience, Institute of Microbiology, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway
    FEMS Immunol Med Microbiol 56:151-61. 2009
    ..This is the first example of such a tandem repeat region of variable length being linked to the expression level of a bacterial gene...
  72. ncbi Allelic diversity of variable number of tandem repeats provides phylogenetic clues regarding the Mycobacterium tuberculosis Beijing family
    Takayuki Wada
    Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8 34 Tojo cho, Tennoji ku, Osaka 543 0026, Japan
    Infect Genet Evol 9:921-6. 2009
    ..It is suggested that VNTR typing can elucidate genetic markers representing the phylogenetic classification in the lineage...
  73. ncbi Genetic diversity of O157:H7 and non-O157 verocytotoxigenic Escherichia coli from Argentina inferred from multiple-locus variable-number tandem repeat analysis (MLVA)
    Ana V Bustamante
    Lab Inmunoquímica y Biotecnología, Dto de Sanidad Animal y Medicina Preventiva, Facultad de Cs Veterinarias, Universidad Nacional del Centro de la Pcia de Buenos Aires, 7000 Tandil, Buenos Aires, Argentina
    Int J Med Microbiol 300:212-7. 2010
    ....
  74. ncbi Genetic characterization of non-O157 verocytotoxigenic Escherichia coli isolated from raw beef products using multiple-locus variable-number tandem repeat analysis
    Tomás Franci
    Laboratorio de Inmunoquimica y Biotecnologia, Departamento de Sanidad Animal y Medicina Preventiva, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina
    Foodborne Pathog Dis 8:1019-23. 2011
    ..As some VNTR markers might be serotype specific, it is possible that the implementation of new VNTR loci will increase intraserotype discrimination...
  75. pmc Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis
    Jacob Kurniawan
    University of New South Wales, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:297-300. 2010
    ..Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia...
  76. ncbi Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Hum Brain Mapp 32:1557-65. 2011
    ....
  77. ncbi Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
    Ronghuan Wang
    Institute of Crop Science, Chinese Academy of Agricultural Sciences National Key Facility for Crop Gene Resources and Genetic Improvement NFCRI, 100081 Beijing, People s Republic of China
    Theor Appl Genet 117:1141-53. 2008
    ..75-40.28% in the subgroups. Among factors influencing LD, linkage was the major cause for LD of SSR loci. The results suggested that the population may be used in the detection of genome-wide SSR marker-phenotype association...
  78. pmc Comparison of multiple-locus variable-number tandem-repeat analysis with pulsed-field gel electrophoresis, spa typing, and multilocus sequence typing for clonal characterization of Staphylococcus aureus isolates
    Natalia Malachowa
    Department of Microbiology, Faculty of Biotechnology, Jagiellonian University, 30 387 Cracow, Poland
    J Clin Microbiol 43:3095-100. 2005
    ....
  79. pmc Association of attention-deficit disorder and the dopamine transporter gene
    E H Cook
    Department of Psychiatry, University of Chicago, IL, USA
    Am J Hum Genet 56:993-8. 1995
    ..Biochemical analysis of such mutations may lead to development of more effective therapeutic interventions...
  80. pmc A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis
    Ik Young Choi
    Soybean Genomics and Improvement Laboratory, USDA, ARS, Beltsville, Maryland 20705, USA
    Genetics 176:685-96. 2007
    ....
  81. pmc Dopamine D4 receptor gene associated with fairness preference in ultimatum game
    Songfa Zhong
    Department of Economics, National University of Singapore, Singapore, Singapore
    PLoS ONE 5:e13765. 2010
    ..This is the first result to link preference for reciprocal fairness to a specific gene and suggests that gene × environment interactions contribute to economic decision making...
  82. pmc Development of multiple-locus variable-number tandem-repeat analysis for molecular typing of Mycoplasma pneumoniae
    S Degrange
    Laboratoire de Bactériologie EA 3671, Mycoplasma and chlamydiae infections in humans, Universite Victor Segalen Bordeaux 2, CHU de Bordeaux, Bordeaux 33076 Cedex, France
    J Clin Microbiol 47:914-23. 2009
    ..The potential value of MLVA of M. pneumoniae as an epidemiological tool is discussed, and the use of the VNTR markers in further investigations of the potential use of MLVA in outbreaks of M. pneumoniae infections is proposed...
  83. pmc Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain
    Sayera Banu
    ICDDR, B Centre for Health and Population Research, Dhaka 1000, Bangladesh
    J Clin Microbiol 42:674-82. 2004
    ....
  84. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  85. pmc Discriminatory power and reproducibility of novel DNA typing methods for Mycobacterium tuberculosis complex strains
    Kristin Kremer
    Mycobacteria Reference Unit, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, P O Box 1, 3720 BA Bilthoven, The Netherlands
    J Clin Microbiol 43:5628-38. 2005
    ..tuberculosis and that VNTR typing is the epidemiological typing method of choice for the near future...
  86. ncbi Evaluation of 24 locus MIRU-VNTR genotyping of Mycobacterium tuberculosis isolates in Canada
    Sara Christianson
    National Microbiology Laboratory, 1015 Arlington Avenue, Winnipeg, Manitoba R3E 3R2, Canada
    Tuberculosis (Edinb) 90:31-8. 2010
    ..For long-term surveillance of MTBC within Canada, the use of 24 MIRU-VNTR loci will provide rapid, highly discriminatory molecular epidemiology information...
  87. ncbi Emergence of reduced susceptibility to metronidazole in Clostridium difficile
    Simon D Baines
    Department of Microbiology, Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 62:1046-52. 2008
    ..We screened recently isolated C. difficile (2005-06) for susceptibility to metronidazole and compared results for historic isolates (1995-2001)...
  88. pmc SVA retrotransposons: Evolution and genetic instability
    Dustin C Hancks
    Department of Genetics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Semin Cancer Biol 20:234-45. 2010
    ..Here we review SVA biology, including SVA insertions associated with known diseases. Further, we discuss a model describing the initial formation of SVA and the mechanisms by which SVA may impact the host...
  89. pmc Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes
    Francesca M Filbey
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Alcohol Clin Exp Res 32:1113-23. 2008
    ..However, to date, the mechanisms that underlie these differences remain largely unknown...
  90. ncbi Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia
    J B Fan
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Charlestown, MA 02129, and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:928-38, 891. 2005
    ....
  91. pmc A real-time PCR array for hierarchical identification of Francisella isolates
    Kerstin Svensson
    Division of CBRN Defense and Security, Swedish Defense Research Agency, Umea, Sweden
    PLoS ONE 4:e8360. 2009
    ....
  92. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
    ..However, the data might also imply that DAT1 has a modulatory rather than causative role in ADHD...
  93. ncbi EST-SSRs as a resource for population genetic analyses
    J R Ellis
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Heredity (Edinb) 99:125-32. 2007
    ..We then discuss the advantages and disadvantages of EST-SSRs in the context of population genetic applications...
  94. pmc Mycobacterium tuberculosis ecology in Venezuela: epidemiologic correlates of common spoligotypes and a large clonal cluster defined by MIRU-VNTR-24
    Edgar Abadia
    Laboratorio de Genetica Molecular, CMBC, Instituto Venezolano de Investigaciones Cientificas IVIC, 1020A Caracas, Venezuela
    BMC Infect Dis 9:122. 2009
    ..tuberculosis strains isolated in Venezuela from 1997 to 2006, predominantly from two large urban centers and two geographically distinct indigenous areas, and then studied a subgroup with MIRU-VNTR 24 loci...
  95. ncbi Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression
    Dubravka Hranilovic
    Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Genetics, Rudjer Boskovic Institute, Zagreb, Croatia
    Biol Psychiatry 55:1090-4. 2004
    ....
  96. pmc Vibrio cholerae strain typing and phylogeny study based on simple sequence repeats
    Yael Danin-Poleg
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Clin Microbiol 45:736-46. 2007
    ..Furthermore, discrimination between 27 strains of the 32 strains was achieved. SSR-based typing methods combining L-SSR and MNR-MLST were found to be efficient for V. cholerae typing...
  97. pmc Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  98. pmc An interspecific linkage map of SSR and intronic polymorphism markers in tomato
    Kenta Shirasawa
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba, 292 0818, Japan
    Theor Appl Genet 121:731-9. 2010
    ..Information on the DNA markers developed in this study is available at http://www.kazusa.or.jp/tomato/...
  99. ncbi Construction of BAC and BIBAC libraries and their applications for generation of SSR markers for genome analysis of chickpea, Cicer arietinum L
    J Lichtenzveig
    Institute of Plant Science and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, 76100, Israel
    Theor Appl Genet 110:492-510. 2005
    ..The BAC and BIBAC libraries and new SSR markers will provide valuable resources for chickpea genomics research and breeding (the libraries and their filters are available to the public at http://hbz.tamu.edu)...
  100. ncbi Linkage disequilibrium between minisatellite loci supports clonal evolution of Mycobacterium tuberculosis in a high tuberculosis incidence area
    Philip Supply
    Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, Cedex, France
    Mol Microbiol 47:529-38. 2003
    ..This linkage disequilibrium was also evident when the MIRU-VNTR types were compared with the IS6110 restriction fragment length polymorphism types. These results support a predominant clonal evolution of M. tuberculosis...
  101. ncbi Construction of an integrated map of rose with AFLP, SSR, PK, RGA, RFLP, SCAR and morphological markers
    Z Yan
    Plant Research International, Wageningen University and Research Centre, P O Box 16, 6700 AA, Wageningen, The Netherlands
    Theor Appl Genet 110:766-77. 2005
    ..The SSR markers, together with RFLP markers, provide good anchor points for future map alignment studies in rose and related species. Codominantly scored AFLP markers were helpful in the integration of the parental maps...

Research Grants67

  1. Mutation Screening of Nicotine and Alcohol Dependence
    RICHARD TODD; Fiscal Year: 2006
    ..abstract_text> ..
  2. Social and Demographic Context and Heritability
    Guang Guo; Fiscal Year: 2003
    ..abstract_text> ..
  3. Epidemiological Investigations of ADHD
    RICHARD TODD; Fiscal Year: 2004
    ..abstract_text> ..
  4. Molecular Epidemiology of Inattentive ADHD
    RICHARD TODD; Fiscal Year: 2008
    ..We note that this affected sib-pair sample would also be ideal to conduct more focused studies of neuroimaging, neuropsychological performance, and neurophysiological functioning in future studies. ..
  5. GENETIC EPIDEMIOLOGY OF ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..abstract_text> ..
  6. Age at First Sex, Genes, Religion, and Other Social and Demographic Context
    Guang Guo; Fiscal Year: 2007
    ....
  7. Mutation Screening of ADHD
    RICHARD TODD; Fiscal Year: 2005
    ..The presence of allelic variation identified using DHPLC will be confirmed by genomic DNA sequencing. Whether specific alleles are associated with subtypes of ADHD will be tested using the Transmission Disequilibrium Test (TDT). ..
  8. Molecular Epidemiology of Alcoholism 2- Big Sibships
    Andrew Heath; Fiscal Year: 2007
    ..abstract_text> ..
  9. Dopamine Genotypes, Experimentally-induced Craving, & Cessation in Female Smokers
    Joel Erblich; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  10. Duke University Center for Translational Research
    Richard Frothingham; Fiscal Year: 2006
    ....
  11. Brown University Shared DNA Sequencer
    John McGeary; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. SEX DIFFERENCES IN NICOTINE REINFORCEMENT: HUMAN/ANIMAL
    Kenneth Perkins; Fiscal Year: 2003
    ....
  14. Dopamine Polymorphisms and Smoking Cue-Reactivity
    Joel Erblich; Fiscal Year: 2006
    ..abstract_text> ..
  15. Alternative endpoints for plague challenge models
    Richard Frothingham; Fiscal Year: 2005
    ..We will use the data generated to refine our hypotheses and to pursue further funding to complete Aim 3. ..
  16. Evaluation of MicroRNA Expression in CD4 T cells in Type 1 Diabetes
    Alberto Pugliese; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. INDIVIDUAL VARIATION IN NICOTINE SENSITIVITY IN HUMANS
    Kenneth Perkins; Fiscal Year: 2003
    ..e., in nicotine-naive individuals). Results will provide directions for future research on vulnerability to tobacco dependence and for targeted efforts to prevent smoking onset. ..
  18. Affect, Context, and Placebo Responses to Nicotine
    Kenneth Perkins; Fiscal Year: 2005
    ..Secondary analyses may identify important individual characteristics associated with placebo responses, aiding in the prediction of which smokers ultimately are likely to benefit most from manipulation of placebo effects. ..
  19. DISCRIMINATIVE STIMULUS EFFECTS OF NICOTINE
    Kenneth Perkins; Fiscal Year: 2001
    ....
  20. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  21. Executive Function: Links to Drug Use & Psychopathology
    Susan Young; Fiscal Year: 2006
    ..Our final aim is to determine the extent to which the covariation between ECF deficits and comorbid psychopathology is due to genetic and/or environmental factors. ..
  22. Regulation of NMDA Receptors in Excitotoxicity by Calpain and FYN
    David Lynch; Fiscal Year: 2007
    ..abstract_text> ..
  23. Analysis of Human Telomeric Structural Variation
    Harold C Riethman; Fiscal Year: 2010
    ....
  24. Gene and Nutrient Etiologies of Human Heart Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because these defects result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  25. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
  27. Development of a Molecular Blood Culture
    David Alland; Fiscal Year: 2010
    ..Rapid identification will make it possible to treat patients with the correct antibiotics more rapidly. This will save patient lives, reduce days in the hospital and permit more rational use of antibiotics. ..
  28. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..This proposal would permit the PI to make a major investment in mentorship, and allow a broadening of his research program in substance dependence. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Alcohol Dependence Genetics in a Large Chinese Pedigree
    Joel Gelernter; Fiscal Year: 2008
    ..This study will improve understanding of the genes that influence risk for alcohol dependence, in Chinese populations, and in comparison with European-American populations. [unreadable] [unreadable] [unreadable]..
  30. CHEMICAL AND BIOLOGICAL MIMICRY OF TELOMERASE
    ERIC KOOL; Fiscal Year: 2007
    ..Chemical approaches to telomere elongation have the long-term potential to solve important problems in transplantation medicine, and to lead to new treatments for senescence-related diseases. ..
  31. RE-ENGINEERING THE DIAMETER OF THE DOULBE HELIX
    Eric T Kool; Fiscal Year: 2010
    ..Finally, we will study basic biophysical, structuraland thermodynamic properties of these compounds, to better understandand delineate their utility as broadly applicable tools. ..
  32. Gene-nutrient Etiologies of Neural Tube Defects
    Gary M Shaw; Fiscal Year: 2010
    ..Because NTDs result in substantial morbidity as well as high emotional and economic costs, further scientific understanding leading to possible prevention would greatly benefit society. ..
  33. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  34. Brain Functional Correlates of MDMA Use in Adolescence
    Leslie Jacobsen; Fiscal Year: 2008
    ..abstract_text> ..
  35. Sample Processing Cartridges for Rapid PCR TB Detection
    David Alland; Fiscal Year: 2008
    ..The system will then be retested using a large number of clinical sputum specimens. Finally, we will develop complete documentation on the assay including production, and development reports. [unreadable] [unreadable] [unreadable]..
  36. Neuroimaging Attentional Impairment During Abstinence
    Francis McClernon; Fiscal Year: 2008
    ..Dr. McClernon will continue to administer current awards and compete for additional extramural funding while he completes the goals of the application. [unreadable] [unreadable] [unreadable] [unreadable]..
  37. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2010
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  38. Prenatal Cocaine Exposure: Studies of Brain Function
    Linda Mayes; Fiscal Year: 2008
    ..C. Mayes). [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  39. Psychobiological /Genetic Determinants-Smoking Cessation
    Sean David; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  40. POPULATION BASED INVESTIGATIONS OF TUBERCULOSIS
    David Alland; Fiscal Year: 2004
    ..Studies of these sequence variations in clinical strains will be used to determine the associations between specific mutations and the phenotypes of infectivity and virulence. ..
  41. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joel Gelernter; Fiscal Year: 2003
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  42. UCI-CFC Projects on School Readiness
    James Swanson; Fiscal Year: 2002
    ....
  43. BASIC DIMENSIONS OF CHILD AND ADOLESCENT PSYCHOPATHOLOGY
    Benjamin Lahey; Fiscal Year: 2004
    ..Potential development and gender differences in the dimensions of psychopathology will be evaluated using structural equation modeling. ..
  44. SUBSTANCE ABUSE AND THE DOPAMINE SYSTEM GENES
    Michael Vanyukov; Fiscal Year: 2004
    ..The results will allow for more accurate estimation of the risk for SUD and suggest approaches for prevention. ..
  45. NOVEL PROBE TOPOLOGIES IN BIOMEDICAL DIAGNOSTICS
    ERIC KOOL; Fiscal Year: 2002
    ..Over the long term, it is hoped that this approach will give rise to clinically useful methods for the early diagnosis of diseases. ..
  46. RESPONSE VARIABILITY IN STIMULANT TREATMENT OF ADHD
    James McGough; Fiscal Year: 2004
    ..In addition to funding the candidate's transition to independent research the proposed study would also contribute to our knowledge of the basis of individual response to medication in psychiatric disorders. ..
  47. Smoking, Brain Function and Outcome in Adolescents
    Leslie Jacobsen; Fiscal Year: 2004
    ..The relationship between the degree of change cognitive performance (assessed prior to and during scanning) in response to recent tobacco use and tobacco use at one-year follow-up will also be examined. ..
  48. Genetic Discrimination Knowledge in Primary Care
    Jeffrey Weitzel; Fiscal Year: 2004
    ..Because genetic testing for hereditary cancer represents a new paradigm for predictive genetic testing in other adult onset disorders, the results of the proposed study will potentially have broad-based implications. ..
  49. FOLATE PATHWAY GENES AND RISK FOR OROFACIAL CLEFTS
    Gary Shaw; Fiscal Year: 2002
    ..abstract_text> ..
  50. CLINICAL CANCER GENETICS EDUCATION
    Jeffrey Weitzel; Fiscal Year: 2005
    ..abstract_text> ..
  51. Genetics of Attention Deficit-Hyperactivity Disorder
    James Swanson; Fiscal Year: 2006
    ..Genomic haplotypes", meaning haplo-specific genotypes at more than one locus, will be defined and tested for possible interactive roles among the genes. ..
  52. PURCHASE OF A VARIAN INOVA 600 MHz NMR SPECTROMETER
    ERIC KOOL; Fiscal Year: 2002
    ..1 T magnet, as well as supershims, two Fullband RF channels with three total RF channels, waveform generators for each channel, a variable temperature unit, pulsed field gradients, a Sun workstation, and a cryo probe. ..
  53. Detection of Select Agents in Single-Well Assays
    David Alland; Fiscal Year: 2007
    ..3. To develop PCR assays that utilize "color-triplet coding" to uniquely label as many as 56 different species-specific molecular beacons. ..
  54. NONPOLAR NUCLEOSIDE ISOSTERES AS BIOMOLECULAR PROBES
    ERIC KOOL; Fiscal Year: 2002
    ..abstract_text> ..
  55. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2006
    ..Varela to develop into an outstanding medical parasitologist and add to the understanding of tick-borne disease and human health. ..
  56. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  57. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  58. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2003
    ..This application is the resubmission of a prior proposal of the same title. ..
  59. LONGITUDINAL FOLLOW UP OF ADHD GIRLS AND THEIR SIBLINGS
    Joseph Biederman; Fiscal Year: 2002
    ....
  60. Stress Resilience in an Animal Model of Depression
    Ruth Kohen; Fiscal Year: 2004
    ..If our hypothesis is true, it would mean a paradigm shift in our understanding of affective illness that could alter the focus of treatment from the current management of symptoms to their prevention ..
  61. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  62. Course of psychopathology in female youth: Analysis with extant longitudinal data
    Joseph Biederman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. Perfusion fMRI of Cue-Induced Nicotine Craving
    Teresa Franklin; Fiscal Year: 2005
    ..Thus, research into its neurological underpinnings is critical in guiding the development of behavioral and pharmacological therapies to battle nicotine addiction. ..
  64. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  65. Genetic Correlates of Alcohol Use Disorders
    Lara Ray; Fiscal Year: 2006
    ..abstract_text> ..
  66. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..
  67. ANTHRAX MOLECULAR EVOLUTION, DIVERSITY AND EPIDEMIOLOGY
    Paul Keim; Fiscal Year: 2003
    ..3) Using Monte Carlo simulations, they will ascertain how the distribution of these markers within and between populations of Bacillus anthracis will be affected by geographic, genetic and ecological processes. ..