odors

Summary

Summary: The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. doi Sensing odorants and pheromones with chemosensory receptors
    Kazushige Touhara
    Department of Integrated Biosciences, The University of Tokyo, Chiba, 277 8562 Japan
    Annu Rev Physiol 71:307-32. 2009
  2. doi Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
    Dieter Wicher
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
    Nature 452:1007-11. 2008
  3. pmc Odorant reception in the malaria mosquito Anopheles gambiae
    Allison F Carey
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 464:66-71. 2010
  4. doi Olfactory signalling in vertebrates and insects: differences and commonalities
    U Benjamin Kaupp
    Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn, Germany
    Nat Rev Neurosci 11:188-200. 2010
  5. pmc A large-scale analysis of odor coding in the olfactory epithelium
    Kiyomitsu Nara
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 31:9179-91. 2011
  6. doi Representations of odor in the piriform cortex
    Dan D Stettler
    Department of Neuroscience and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 63:854-64. 2009
  7. ncbi Genetic variation in a human odorant receptor alters odour perception
    Andreas Keller
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 449:468-72. 2007
  8. doi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
  9. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
  10. doi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008

Research Grants

  1. BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTION
    Brian Smith; Fiscal Year: 2007
  2. Molecular basis of olfactory perception.
    DAVID NIGEL JONES; Fiscal Year: 2010
  3. Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants
    Anandasankar Ray; Fiscal Year: 2010
  4. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2010
  5. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2011
  6. Multiple Mechanisms of Nasal Chemoreception
    DIEGO contact RESTREPO; Fiscal Year: 2010
  7. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2009
  8. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2009
  9. Parasite / host interaction and the neurobiology of fear
    Robert M Sapolsky; Fiscal Year: 2010
  10. MECHANISMS OF OLFACTORY TRANSDUCTION
    John Teeter; Fiscal Year: 2003

Detail Information

Publications333 found, 100 shown here

  1. doi Sensing odorants and pheromones with chemosensory receptors
    Kazushige Touhara
    Department of Integrated Biosciences, The University of Tokyo, Chiba, 277 8562 Japan
    Annu Rev Physiol 71:307-32. 2009
    ..We review recent progress on chemosensory receptor structure, function, and circuitry in vertebrates and invertebrates from the point of view of the molecular biology and physiology of these sensory systems...
  2. doi Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
    Dieter Wicher
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
    Nature 452:1007-11. 2008
    ..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
  3. pmc Odorant reception in the malaria mosquito Anopheles gambiae
    Allison F Carey
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Nature 464:66-71. 2010
    ..Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria...
  4. doi Olfactory signalling in vertebrates and insects: differences and commonalities
    U Benjamin Kaupp
    Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn, Germany
    Nat Rev Neurosci 11:188-200. 2010
    ..Metabotropic signalling in vertebrates provides a rich panoply of positive and negative regulation, whereas ionotropic signalling in insects enhances processing speed...
  5. pmc A large-scale analysis of odor coding in the olfactory epithelium
    Kiyomitsu Nara
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 31:9179-91. 2011
    ..at this level, we tested the responses of 3000 mouse OSNs to 125 odorants with diverse structures and perceived odors. These studies revealed extraordinary diversity, but also bias, in odorant recognition by the OSN, and thus OR, ..
  6. doi Representations of odor in the piriform cortex
    Dan D Stettler
    Department of Neuroscience and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 63:854-64. 2009
    ..This representation suggests organizational principles that differ from those in neocortical sensory areas where cells responsive to similar stimulus features are clustered and response properties vary smoothly across the cortex...
  7. ncbi Genetic variation in a human odorant receptor alters odour perception
    Andreas Keller
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 449:468-72. 2007
    ..Our results demonstrate the first link between the function of a human odorant receptor in vitro and odour perception...
  8. doi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
    ..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
  9. pmc Receptors and neurons for fly odors in Drosophila
    Wynand Van der Goes van Naters
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Curr Biol 17:606-12. 2007
    ..We find that none respond strongly to food odors but that all respond to fly odors...
  10. doi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ....
  11. pmc Divisive normalization in olfactory population codes
    Shawn R Olsen
    Harvard Medical School, Department of Neurobiology, Boston, MA 02115, USA
    Neuron 66:287-99. 2010
    ....
  12. pmc Lateral presynaptic inhibition mediates gain control in an olfactory circuit
    Shawn R Olsen
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 452:956-60. 2008
    ..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
  13. pmc Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae
    Guirong Wang
    Department of Biological Sciences, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 107:4418-23. 2010
    ..gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases...
  14. ncbi Speed and accuracy of olfactory discrimination in the rat
    Naoshige Uchida
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:1224-9. 2003
    ..Even when pushed to psychophysical limits using mixtures of two odors, rats needed to take only one sniff (<200 ms at theta frequency) to make a decision of maximum accuracy...
  15. ncbi Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb
    K J Ressler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Cell 79:1245-55. 1994
    ..In our view, this map is in essence an epitope map, whose approximately 1000 distinct components are used in a multitude of different combinations to discriminate a vast array of different odors.
  16. ncbi Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory
    Christelle Rochefort
    Perception and Memory Laboratory, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Institut Pasteur, 75 724 Paris Cedex 15, France
    J Neurosci 22:2679-89. 2002
    ..By maintaining a constitutive turnover of granule cells subjected to modulation by environmental cues, ongoing bulbar neurogenesis could be associated with improved olfactory memory...
  17. pmc Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb
    Ryan M Carey
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 31:10615-26. 2011
    ....
  18. pmc Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice
    Francoise Lazarini
    Institut Pasteur, Laboratory for Perception and Memory, Paris, France
    PLoS ONE 4:e7017. 2009
    ..Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear...
  19. doi How is the olfactory map formed and interpreted in the mammalian brain?
    Kensaku Mori
    Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Annu Rev Neurosci 34:467-99. 2011
    ....
  20. doi Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb
    Kevin M Cury
    Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 68:570-85. 2010
    ..These results suggest that inhalation-coupled transient activity forms a robust neural code that is invariant to changes in respiration behavior...
  21. doi Odorant emissions from intensive pig production measured by online proton-transfer-reaction mass spectrometry
    Anders Feilberg
    Department of Biosystems Engineering, Aarhus University, Blichers alle 20, DK 8830 Tjele, Denmark
    Environ Sci Technol 44:5894-900. 2010
    ..Highest emissions are seen for hydrogen sulfide and acetic acid, whereas key odorants are evaluated from tabulated odor threshold values to be hydrogen sulfide, methanethiol, 4-methylphenol, and butanoic acid...
  22. ncbi Naris occlusion alters the electro-olfactogram: evidence for compensatory plasticity in the olfactory system
    Christopher T Waggener
    Department of Biology, Randolph Macon College, Ashland, VA 23005, USA
    Neurosci Lett 427:112-6. 2007
    ..This result was consistent across turbinates, odors, and all but the highest odor concentration...
  23. doi Antennal lobe processing increases separability of odor mixture representations in the honeybee
    Nina Deisig
    Research Centre for Animal Cognition UMR 5169, Universite de Toulouse, UPS, Toulouse, France
    J Neurophysiol 103:2185-94. 2010
    ..As a result, mixture representations become more separable in the olfactory space, thus allowing better differentiation among floral blends in nature...
  24. ncbi Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
    Fuqiang Xu
    Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
    J Comp Neurol 489:491-500. 2005
    It is generally believed that the main olfactory system processes common odors and the accessory olfactory system is specifically for pheromones...
  25. pmc Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors
    Ajai Vyas
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:6442-7. 2007
    ..In mice and rats, latent Toxoplasma infection converted the aversion to feline odors into attraction...
  26. doi Navigational strategies used by insects to find distant, wind-borne sources of odor
    Ring T Cardé
    Department of Entomology, University of California, Riverside, CA 92521, USA
    J Chem Ecol 34:854-66. 2008
    ....
  27. pmc Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae
    Tan Lu
    Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Curr Biol 17:1533-44. 2007
    ..However, the molecular and cellular basis of such olfactory responses remains largely unknown...
  28. doi Precise olfactory responses tile the sniff cycle
    Roman Shusterman
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
    Nat Neurosci 14:1039-44. 2011
    ..The spikes of single neurons carried sufficient information to discriminate odors. In addition, precise locking to sniff phase may facilitate ensemble coding by making synchrony relationships ..
  29. pmc Associative cortex features in the first olfactory brain relay station
    Wilder Doucette
    Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Neuron 69:1176-87. 2011
    ..We observed that as mice learned to discriminate between odors, synchronous firing responses to the rewarded and unrewarded odors became divergent...
  30. ncbi Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice
    Nixon M Abraham
    WIN Group of Olfactory Dynamics, Heidelberger Akademie der Wissenschaften and Max Planck Institut für medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Neuron 44:865-76. 2004
    ..go/no-go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%...
  31. ncbi Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons
    John P McGann
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Neuron 48:1039-53. 2005
    ..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity...
  32. doi Enzymatic conversion of odorants in nasal mucus affects olfactory glomerular activation patterns and odor perception
    Ayumi Nagashima
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo 113 8675, Japan
    J Neurosci 30:16391-8. 2010
    ..These results reveal that the enzymatic conversion of odorants in the nasal mucus appears be fast enough to affect olfactory perception, which sheds light on the previously unappreciated role of nasal mucosal enzymes in odor sensation...
  33. doi Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors
    Vincent Breton-Provencher
    Cellular Neurobiology Unit, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    J Neurosci 29:15245-57. 2009
    ..Altogether, our data highlight the importance of adult neurogenesis for the proper functioning of the OB network and imply that new bulbar interneurons are involved in some, but not all, odor-associated tasks...
  34. ncbi The molecular basis of odor coding in the Drosophila antenna
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 117:965-79. 2004
    ..Receptors vary widely in their breadth of tuning, and odorants vary widely in the number of receptors they activate. Together, these properties provide a molecular basis for odor coding by the receptor repertoire of an olfactory organ...
  35. pmc Odor information processing by the olfactory bulb analyzed in gene-targeted mice
    Jie Tan
    Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Neuron 65:912-26. 2010
    ..Our results indicate that olfactory information carried by an OR is channeled to its corresponding M/T cells and support the role of lateral inhibition via interneurons in sharpening the tuning of M/T cells...
  36. pmc Development of a portable electronic nose system for the detection and classification of fruity odors
    Kea Tiong Tang
    Department of Electrical Engineering, National Tsing Hua University No 101, Sec 2, Kuang Fu Road, Hsinchu, Taiwan
    Sensors (Basel) 10:9179-93. 2010
    ..Verification software was developed to verify system functions. Experimental results indicate that the proposed system prototype is able to identify the fragrance of three fruits, namely lemon, banana, and litchi...
  37. ncbi Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies
    J B Connolly
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 274:2104-7. 1996
    ..The ability to associate odors with electroshock was abolished when Galphas* was targeted to MB, but not CC, structures, whereas sensorimotor ..
  38. pmc Functional architecture of olfactory ionotropic glutamate receptors
    Liliane Abuin
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Neuron 69:44-60. 2011
    ..Our results provide insights into the conserved and distinct architecture of these olfactory and synaptic ion channels and offer perspectives into the use of IRs as genetically encoded chemical sensors...
  39. doi Insect odorant receptors are molecular targets of the insect repellent DEET
    Mathias Ditzen
    Laboratory of Neurogenetics and Behavior, Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065 USA
    Science 319:1838-42. 2008
    ..Here, we show that DEET blocks electrophysiological responses of olfactory sensory neurons to attractive odors in Anopheles gambiae and Drosophila melanogaster...
  40. doi Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice
    Nixon M Abraham
    Institute of Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Neuron 65:399-411. 2010
    ..cells via granule cells may contribute to odor discrimination behavior by refining neuronal representations of odors. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca(2+) ..
  41. pmc Characterization of an antennal carboxylesterase from the pest moth Spodoptera littoralis degrading a host plant odorant
    Nicolas Durand
    UMR A 1272 UPMC INRA Physiologie de l Insecte, Université Pierre et Marie Curie and INRA, Paris and Versailles, France
    PLoS ONE 5:e15026. 2010
    ..These enzymes are only expressed in the male antennae, and secreted into the lumen of the pheromone-sensitive sensilla. CCEs able to hydrolyze other odorants than sex pheromones, such as plant volatiles, have not been identified...
  42. ncbi The sniff as a unit of olfactory processing
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Chem Senses 31:167-79. 2006
    ..Recent behavioral experiments show that using a single sniff rats can accurately discriminate between very similar odors and fail to improve their accuracy by taking multiple sniffs...
  43. ncbi Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects
    T Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307, Dresden, Germany
    Eur Arch Otorhinolaryngol 264:237-43. 2007
    ..Further, the present data suggest specific changes of individual olfactory functions in relation to age, with odor thresholds declining most dramatically compared to odor discrimination and odor identification...
  44. pmc Associative conditioning tunes transient dynamics of early olfactory processing
    Patricia C Fernandez
    Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
    J Neurosci 29:10191-202. 2009
    b>Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear...
  45. pmc Select Drosophila glomeruli mediate innate olfactory attraction and aversion
    Julia L Semmelhack
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Nature 459:218-23. 2009
    ..Together, these results indicate that individual glomeruli, rather than the entire pattern of active glomeruli, mediate innate behavioural output...
  46. pmc Characterization and coding of behaviorally significant odor mixtures
    Jeffrey A Riffell
    University of Arizona, Tucson, 85721, USA
    Curr Biol 19:335-40. 2009
    ..Surprisingly, how the olfactory system maintains identity of complex odors is unclear [6-10]...
  47. pmc Chemotopic odorant coding in a mammalian olfactory system
    Brett A Johnson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
    J Comp Neurol 503:1-34. 2007
    ..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
  48. ncbi Coding of odors by a receptor repertoire
    Elissa A Hallem
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 125:143-60. 2006
    ..We test the receptors with a panel of over 100 odors and find that strong responses are sparse, with response density dependent on chemical class...
  49. doi Precision and diversity in an odor map on the olfactory bulb
    Edward R Soucy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 12:210-20. 2009
    ..Identified glomeruli could be matched across animals by their response profile to hundreds of odors. Their layout in different individuals varied by only approximately 1 glomerular spacing, corresponding to a ..
  50. doi Olfactory coding with patterns of response latencies
    Stephan Junek
    Department of Neurophysiology and Cellular Biophysics, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Neuron 67:872-84. 2010
    The encoding of odors by spatiotemporal patterns of mitral/tufted (M/T) cells in the vertebrate olfactory bulb has been discussed controversially...
  51. pmc Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination
    Alexander Fleischmann
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 60:1068-81. 2008
    We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71...
  52. ncbi Centre-surround inhibition among olfactory bulb glomeruli
    J L Aungst
    Department of Anatomy and Neurobiology, Program in Neuroscience, The University of Maryland School of Medicine, Room 222, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Nature 426:623-9. 2003
    ..This interglomerular centre-surround inhibitory network, along with the well-established mitral-granule-mitral inhibitory circuit, forms a serial, two-stage inhibitory circuit that could enhance spatiotemporal responses to odours...
  53. pmc Odor quality coding and categorization in human posterior piriform cortex
    James D Howard
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 12:932-8. 2009
    ..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
  54. ncbi Information processing in the mammalian olfactory system
    Pierre Marie Lledo
    Laboratory of Perception and Memory, Pasteur Institute, Paris, France
    Physiol Rev 85:281-317. 2005
    ..Recent observations supporting the necessity of such plasticity for adult brain functions are also discussed. Due to space constraints, this review focuses mainly on the olfactory systems of vertebrates, and primarily those of mammals...
  55. ncbi Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity
    R W Friedrich
    California Institute of Technology, Division of Biology, MC 139-74, Pasadena, CA 91125, USA
    Science 291:889-94. 2001
    Mitral cells (MCs) in the olfactory bulb (OB) respond to odors with slow temporal firing patterns...
  56. pmc The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs
    Fabio Papes
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 141:692-703. 2010
    ..Neurons that sense these stimuli remain unknown. Here we show that detection and processing of fear-evoking odors emitted from cat, rat, and snake require the function of sensory neurons in the vomeronasal organ...
  57. ncbi Intrinsic and circuit properties favor coincidence detection for decoding oscillatory input
    Javier Perez-Orive
    Computation and Neural Systems, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 24:6037-47. 2004
    ..Finally, we find that a decoding strategy that is based on coincidence detection enhances both noise tolerance and input discriminability by KCs...
  58. doi Stability of odorants from pig production in sampling bags for olfactometry
    Michael J Hansen
    Department of Biosystems Engineering, Aarhus University, Tjele, Denmark
    J Environ Qual 40:1096-102. 2011
    ..This can result in underestimation of odor emissions from pig production facilities and of the effect of odor reduction technologies...
  59. doi Odor detection in insects: volatile codes
    M de Bruyne
    Biological Sciences, Monash University, Clayton, Australia
    J Chem Ecol 34:882-97. 2008
    ..We promote a more integrated research approach that links molecular physiology of receptor neurons to the ecology of odorants...
  60. pmc The averaging effect of odorant mixing as determined by air dilution sensory tests: a case study on reduced sulfur compounds
    Ki Hyun Kim
    Atmospheric Environment Laboratory, Department of Environment and Energy, Sejong University, Seoul 143 747, Korea
    Sensors (Basel) 11:1405-17. 2011
    ..The overall results of this study thus suggest that the mixing phenomenon between odorants with similar chemical properties (like RSC family) can be characterized by the averaging effect of all participants...
  61. pmc Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse
    Ashesh K Dhawale
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:1404-12. 2010
    ..Sister cells had highly correlated responses to odors, as measured by average spike rates, but their spike timing in relation to respiration was differentially altered...
  62. pmc Biophysical mechanisms underlying olfactory receptor neuron dynamics
    Katherine I Nagel
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:208-16. 2011
    The responses of olfactory receptor neurons (ORNs) to odors have complex dynamics...
  63. pmc Optical imaging of postsynaptic odor representation in the glomerular layer of the mouse olfactory bulb
    Max L Fletcher
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurophysiol 102:817-30. 2009
    ....
  64. ncbi Combinatorial receptor codes for odors
    B Malnic
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:713-23. 1999
    ..of the mammalian olfactory system is such that thousands of volatile chemicals are perceived as having distinct odors. Here we used a combination of calcium imaging and single-cell RT-PCR to identify odorant receptors (ORs) for ..
  65. ncbi Mice deficient in G(olf) are anosmic
    L Belluscio
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 20:69-81. 1998
    ..striking reduction in the electrophysiological response of primary olfactory sensory neurons to a wide variety of odors. Despite this profound diminution in response to odors, the topographic map of primary sensory projections to the ..
  66. pmc A general odorant background affects the coding of pheromone stimulus intermittency in specialist olfactory receptor neurones
    Angela Rouyar
    UMR1272, PISC, Institut National de la Recherche Agronomique Université Pierre et Marie Curie, Versailles, France
    PLoS ONE 6:e26443. 2011
    ..Rapid recovery of behavior shows that change of perceived intensity is more important than absolute stimulus intensity. While decreasing the response intensity, background odor preserved the temporal parameters of the specific signal...
  67. doi Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect
    Romina B Barrozo
    INRA, UMR 1272 Physiologie de l Insecte Signalisation et Communication, Route de St Cyr, F 78000 Versailles, France
    J Exp Biol 213:2933-9. 2010
    ....
  68. ncbi Optical imaging of odorant representations in the mammalian olfactory bulb
    B D Rubin
    Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neuron 23:499-511. 1999
    ..These characteristics suggest that odorants and their concentrations can be encoded by distinct spatial patterns of glomerular activation...
  69. ncbi Deficit in attachment behavior in mice lacking the mu-opioid receptor gene
    Anna Moles
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Psychobiology and Psychopharmacology, Viale Marx 43, 00137 Roma, Italy
    Science 304:1983-6. 2004
    ..pups emit fewer ultrasonic vocalizations when removed from their mothers but not when exposed to cold or male mice odors. Moreover these knockout pups do not show a preference toward their mothers' cues and do not show ultrasonic calls ..
  70. pmc Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model
    Daniel W Wesson
    Emotional Brain Institute and Center for Dementia Research, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    J Neurosci 30:505-14. 2010
    ..Furthermore, these results present the odor cross-habituation test as a powerful behavioral assay, which reflects Abeta deposition and thus may serve to monitor the efficacy of therapies aimed at reducing Abeta...
  71. doi Central processing of natural odor mixtures in insects
    Hong Lei
    ARL Neurobiology, University of Arizona, Tucson, AZ 85721, USA
    J Chem Ecol 34:915-27. 2008
    ..The difference between these two types of processing may reside in the degree of plasticity, with the former being hard-wired and the latter being more subjected to network modulation...
  72. pmc Bulbar acetylcholine enhances neural and perceptual odor discrimination
    Dipesh Chaudhury
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14850, USA
    J Neurosci 29:52-60. 2009
    ..These results together present a first direct comparison between neural and perceptual effects of a bulbar neuromodulator...
  73. ncbi The olfactory bulb: coding and processing of odor molecule information
    K Mori
    Laboratory for Neuronal Recognition Molecules, Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Science 286:711-5. 1999
    ..They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex...
  74. pmc Electronic noses and tongues: applications for the food and pharmaceutical industries
    Elizabeth A Baldwin
    USDA ARS Citrus and Subtropical Products Laboratory, 600 Ave S N W, Winter Haven, FL 33881, USA
    Sensors (Basel) 11:4744-66. 2011
    ..The electronic tongue reacts similarly to non-volatile compounds in a liquid. This review will concentrate on applications of e-nose and e-tongue technology for edible products and pharmaceutical uses...
  75. ncbi A zonal organization of odorant receptor gene expression in the olfactory epithelium
    K J Ressler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115
    Cell 73:597-609. 1993
    The mechanisms by which mammals discriminate a vast array of diverse odors are poorly understood...
  76. ncbi Mitral and tufted cells differ in the decoding manner of odor maps in the rat olfactory bulb
    Shin Nagayama
    Department of Physiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurophysiol 91:2532-40. 2004
    ..These results indicate a clear difference between mitral and middle tufted cells in the manner of decoding the glomerular odor maps...
  77. ncbi Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus
    Gloria B Choi
    Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 46:647-60. 2005
    ..Our data therefore identify a potential neural substrate for integrating the influences of conflicting behavioral cues and a transcription factor family that may contribute to the development of this substrate...
  78. ncbi Neural representation of olfactory mixtures in the honeybee antennal lobe
    Nina Deisig
    Research Centre for Animal Cognition, CNRS Université Paul Sabatier UMR 5169, 31062 Toulouse Cedex 04, France
    Eur J Neurosci 24:1161-74. 2006
    Natural olfactory stimuli occur as mixtures of many single odors. We studied whether the representation of a mixture in the brain retains single-odor information and how much mixture-specific information it includes...
  79. ncbi Maps of odorant molecular features in the Mammalian olfactory bulb
    Kensaku Mori
    Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Physiol Rev 86:409-33. 2006
    ..The molecular-feature maps provide a basis for understanding how the olfactory cortex reads the odor maps of the OB...
  80. pmc Sensory processing in the Drosophila antennal lobe increases reliability and separability of ensemble odor representations
    Vikas Bhandawat
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:1474-82. 2007
    ..Finally, we show that a linear discriminator classifies odors more accurately using PN spike trains than using an equivalent number of ORN spike trains.
  81. ncbi Sniffing controls an adaptive filter of sensory input to the olfactory bulb
    Justus V Verhagen
    Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:631-9. 2007
    ..Mammals sample odors by sniffing, a complex behavior that controls odorant access to receptor neurons...
  82. ncbi Component information is preserved in glomerular responses to binary odor mixtures in the moth Spodoptera littoralis
    Mikael A Carlsson
    Department of Safety Pharmacology, AstraZeneca R and D Sodertalje, SE 151 85 Södertälje, Sweden
    Chem Senses 32:433-43. 2007
    Natural odors are often complex mixtures of different compounds. These mixtures can be perceived to have qualities that are different from their components...
  83. doi Olfactory information processing in Drosophila
    Nicolas Y Masse
    Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Curr Biol 19:R700-13. 2009
    ..We emphasise our emerging understanding of how different elementary computations, including signal averaging, gain control, decorrelation and integration, may be mapped onto different circuit elements...
  84. pmc Neural correlates of behavior in the moth Manduca sexta in response to complex odors
    Jeffrey A Riffell
    Department of Neuroscience, University of Arizona, Tucson AZ 85721 0077, USA
    Proc Natl Acad Sci U S A 106:19219-26. 2009
    ..ensembles to mixtures of varying behavioral effectiveness, we analyzed the coding of behaviorally "meaningful" odors. We considered four possible ensemble-coding mechanisms--mean firing rate, mean instantaneous firing rate, pattern ..
  85. pmc Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odors
    Baranidharan Raman
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:1994-2006. 2010
    ..How then are dynamic neural codes for odors generated? Consistent with recent results from several other species, our recordings from locust ORNs showed a ..
  86. doi A metric for odorant comparison
    Rafi Haddad
    Department of Neurobiology, Weizmann Institute of Science, Hertzel, Rehovot 76100 Israel
    Nat Methods 5:425-9. 2008
    ..We use this new metric to recommend sets of odorants that span the physicochemical space for use in olfaction experiments...
  87. ncbi Spatio-temporal dynamics of odor representations in the mammalian olfactory bulb
    Hartwig Spors
    The Department of Neurobiology, Weizmann Institute of Science, 76100, Rehovot, Israel
    Neuron 34:301-15. 2002
    ..Our data show that in the mammalian olfactory bulb, odor identity and concentration are represented by spatio-temporal patterns, rather than spatial patterns alone...
  88. pmc The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae
    Yuanfeng Xia
    Department of Biological Sciences and Pharmacology, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 105:6433-8. 2008
    ..These advances may ultimately enhance the development of vector control strategies, targeting olfactory pathways in larval-stage mosquitoes to reduce the catastrophic effects of malaria and other diseases...
  89. pmc A circuit supporting concentration-invariant odor perception in Drosophila
    Kenta Asahina
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Biol 8:9. 2009
    Most odors are perceived to have the same quality over a large concentration range, but the neural mechanisms that permit concentration-invariant olfactory perception are unknown...
  90. ncbi Computational modeling suggests that response properties rather than spatial position determine connectivity between olfactory glomeruli
    Christiane Linster
    Cornell University, Mudd Hall, Ithaca, NY 14853, USA
    J Neurophysiol 93:3410-7. 2005
    ....
  91. doi Irresistible bouquet of death--how are burying beetles (Coleoptera: Silphidae: Nicrophorus) attracted by carcasses
    B Kalinová
    Infochemicals Group, Institute of Organic Chemistry and Biochemistry v v i, Academy of Sciences of the Czech Republic, Flemingovo nam 2, 166 10, Prague 6, Czech Republic
    Naturwissenschaften 96:889-99. 2009
    ..The data suggest that sulphur-containing chemicals are involved in mediating the fresh carcass attractiveness for N. vespillo and N. vespilloides...
  92. pmc A resting box for outdoor sampling of adult Anopheles arabiensis in rice irrigation schemes of lower Moshi, northern Tanzania
    Eliningaya J Kweka
    Tropical Pesticides Research Institute, Division of Livestock and Human Diseases Vector Control, Arusha, Tanzania
    Malar J 8:82. 2009
    ..In this study, human landing catch, two cow odour baited resting boxes and an unbaited resting box were evaluated as vector sampling tools in an area with a high proportion of Anopheles arabiensis, as the major malaria vector...
  93. doi Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons
    Sulagna Ghosh
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 472:217-20. 2011
    ....
  94. ncbi The coding of odour-intensity in the honeybee antennal lobe: local computation optimizes odour representation
    Silke Sachse
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Str 28 30, 14195 Berlin, Germany
    Eur J Neurosci 18:2119-32. 2003
    ....
  95. pmc Women with a history of childhood maltreatment exhibit more activation in association areas following non-traumatic olfactory stimuli: a fMRI study
    Ilona Croy
    Department of Psychosomatic Therapy, University of Dresden Medical School, Dresden, Germany
    PLoS ONE 5:e9362. 2010
    ..The focus on olfactory perception is based on the overlap of brain areas often proposed to be affected in CM patients and the projection areas of the olfactory system, including the amygdala, orbitofrontal cortex, insula and hippocampus...
  96. doi Processing of disgusted faces is facilitated by odor primes: a functional MRI study
    Janina Seubert
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 53:746-56. 2010
    ..These results indicate the presence of a central network with modality-specific and -unspecific components modulating emotional face recognition...
  97. ncbi Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids
    H Berglund
    Department of Medicine, Division of Neurology, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institute, MR Centre, Stockholm, Sweden
    Cereb Cortex 18:1900-8. 2008
    ..Instead, the data implicate that transsexuality may be associated with sex-atypical physiological responses in specific hypothalamic circuits, possibly as a consequence of a variant neuronal differentiation...
  98. doi A novel multicomponent stimulus device for use in olfactory experiments
    Shannon B Olsson
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knoell Strasse 8, Jena, Germany
    J Neurosci Methods 195:1-9. 2011
    ..multicomponent stimulus system for use in olfactory experiments that is capable of presenting up to 8 different odors simultaneously or in sequence at defined concentrations and time scales...
  99. doi Mixture interactions in moth olfactory physiology: examining the effects of odorant mixture, concentration, distal stimulation, and antennal nerve transection on sensillar responses
    N K Hillier
    Department of Biology, Acadia University, Wolfville, Nova Scotia B4P2R6, Canada
    Chem Senses 36:93-108. 2011
    ..virescens ORNs...
  100. pmc Differential attraction of malaria mosquitoes to volatile blends produced by human skin bacteria
    Niels O Verhulst
    Laboratory of Entomology, Wageningen University and Research Centre, Wageningen, The Netherlands
    PLoS ONE 5:e15829. 2010
    ..This information will be used in the further development of a blend of semiochemicals for the manipulation of mosquito behaviour...
  101. pmc Normalization for sparse encoding of odors by a wide-field interneuron
    Maria Papadopoulou
    Division of Biology, Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA
    Science 332:721-5. 2011
    ..In the insect olfactory system, the representation of general odors is dense in the antennal lobes but sparse in the mushroom bodies, only one synapse downstream...

Research Grants99

  1. BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTION
    Brian Smith; Fiscal Year: 2007
    ..honeybee (Apis mellifera) as a model animal species for understanding mechanisms of behavioral plasticity toward odors. These animals are faced with the same types of olfactory problems as mammals...
  2. Molecular basis of olfactory perception.
    DAVID NIGEL JONES; Fiscal Year: 2010
    ..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
  3. Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using Odorants
    Anandasankar Ray; Fiscal Year: 2010
    ..identify their human hosts primarily using olfactory cues like carbon dioxide in exhaled breath, as well as other odors present in skin emanations...
  4. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2010
    ..Moreover, despite evidence in animals that such biologically relevant odors may act as natural rewards, the routes through which odors are conveyed to the mesolimbic dopamine system that ..
  5. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2011
    ..Moreover, despite evidence in animals that such biologically relevant odors may act as natural rewards, the routes through which odors are conveyed to the mesolimbic dopamine system that ..
  6. Multiple Mechanisms of Nasal Chemoreception
    DIEGO contact RESTREPO; Fiscal Year: 2010
    ..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006;Buck, 2005;Lin et al., 2007;Lin et al., 2004)...
  7. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2009
    ..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006; Buck, 2005; Lin et al., 2007; Lin et al., 2004)...
  8. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2009
    ..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006; Buck, 2005; Lin et al., 2007; Lin et al., 2004)...
  9. Parasite / host interaction and the neurobiology of fear
    Robert M Sapolsky; Fiscal Year: 2010
    ..evolved the capacity to, once having formed cysts in the brain, abolish the innate fear that rodents have of the odors of cats, and to convert that fear into an attraction;this increases the likelihood of the rodent being predated, ..
  10. MECHANISMS OF OLFACTORY TRANSDUCTION
    John Teeter; Fiscal Year: 2003
    ..our overall quality of life is becoming increasingly appreciated with advances in our understanding of how odors influence the enjoyment of food and beverages and our sense of well-being...
  11. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2009
    ..to characterize the dynamics and the specificity of the responses of OSNs to a large variety of odorants, complex odors, and pheromones...
  12. Parasite / host interaction and the neurobiology of fear
    Robert Sapolsky; Fiscal Year: 2009
    ..evolved the capacity to, once having formed cysts in the brain, abolish the innate fear that rodents have of the odors of cats, and to convert that fear into an attraction; this increases the likelihood of the rodent being predated, ..
  13. Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory N
    Albert Folch; Fiscal Year: 2010
    ..to characterize the dynamics and the specificity of the responses of OSNs to a large variety of odorants, complex odors, and pheromones...
  14. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2011
    ..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
  15. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
    ..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
  16. Molecular mechanisms of olfaction in mammals
    Linda Buck; Fiscal Year: 2009
    ..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
  17. Molecular mechanisms of olfaction in mammals
    Linda B Buck; Fiscal Year: 2010
    ..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
  18. Taste, smell, and feeding behavior in autism: A quantitative traits study
    Loisa Bennetto; Fiscal Year: 2009
    ..processing, there is considerable evidence that children with autism show unusual responses to tastes and odors, and we have recently documented autism-specific impairments in psychophysiological tests of taste and odor ..
  19. Taste, smell, and feeding behavior in autism: A quantitative traits study
    Loisa Bennetto; Fiscal Year: 2010
    ..processing, there is considerable evidence that children with autism show unusual responses to tastes and odors, and we have recently documented autism-specific impairments in psychophysiological tests of taste and odor ..
  20. Psychoneuroimmunology and Mind-Body Medicine
    Janice Kiecolt Glaser; Fiscal Year: 2005
    ..This design will allow us to examine the ability of the odors to modulate autonomic, endocrine, and immune function, and health-relevant cutaneous responses...
  21. Contribution of Estradiol to Female Neural Development
    Michael Baum; Fiscal Year: 2006
    ..no estradiol due to a targeted mutation in the aromatase gene, showed little interest in approaching volatile odors derived from conspecifics of either sex and showed low levels of sexual receptivity after adult treatment with ..
  22. MOLECULAR BASIS OF OLFACTORY DISCRIMINATION
    Linda Buck; Fiscal Year: 2005
    ..and discrimination of a vast number of structurally diverse odorants that are perceived as having different odors. On the other, it mediates the detection of pheromones, chemicals released from animals that stimulate ..
  23. Dynamics of glomerular coding in the olfactory bulb
    DALE M WACHOWIAK; Fiscal Year: 2010
    ..by applicant): The goal of this research is to understand how the nervous system encodes information about odors. The sense of smell presents unique problems to the nervous system in terms of stimulus detection, neural encoding ..
  24. Dynamics of glomerular coding in the olfactory bulb
    DALE WACHOWIAK; Fiscal Year: 2009
    ..by applicant): The goal of this research is to understand how the nervous system encodes information about odors. The sense of smell presents unique problems to the nervous system in terms of stimulus detection, neural encoding ..
  25. INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULI
    Ruth Wood; Fiscal Year: 2003
    ..Castration also reduces sexual motivation, as measured by interest in vaginal odors and preference for a receptive female...
  26. INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULI
    Ruth Wood; Fiscal Year: 2006
    ..Castration also reduces sexual motivation, as measured by interest in vaginal odors and preference for a receptive female...
  27. STRUCT/FUNCTIONAL GENOMICS OF OLFACTORY RECEPTOR GENES
    Barbara Trask; Fiscal Year: 2002
    Our ability to smell thousands of different odors is mediated by a large repertoire of odorant receptors (OR) expressed on sensory neurons in the nose. The Ors bind odorous molecules and transmit this information to the brain...
  28. Neural substrates of taste, smell and flavor in humans
    DANA SMALL; Fiscal Year: 2006
    ..brain response in healthy human volunteer subjects to tastes presented in isolation and tastes presented with odors. The neural substrates of taste must code for three major perceptual dimensions of taste; namely, intensity, ..
  29. Unconventional receptor neurons in nasal epithelia
    ANNELOTTE HANSEN; Fiscal Year: 2007
    ..The common view attributes ciliated receptor neurons to the main olfactory epithelium to detect mainly food odors and microvillus receptor neurons to the vomeronasal organ to detect sexual/social cues...
  30. Molecular basis of olfactory perception.
    David Jones; Fiscal Year: 2009
    ..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
  31. Molecular basis of olfactory perception.
    David Jones; Fiscal Year: 2007
    ..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
  32. GENETIC AND MOLECULAR ANALYSIS OF OLFACTION
    John R Carlson; Fiscal Year: 2010
    ..The behavior elicited by pairs of odors is then analyzed...
  33. Glycoconjugates in Cell Cell Interactions
    GERALD SCHWARTING; Fiscal Year: 2005
    ..Most mammalian species, including humans, have the ability to distinguish thousands of different odors. This ability is encoded in the organized connections made between olfactory sensory neurons in the nasal cavity ..
  34. BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTION
    Brian Smith; Fiscal Year: 2009
    ..honeybee (Apis mellifera) as a model animal species for understanding mechanisms of behavioral plasticity toward odors. These animals are faced with the same types of olfactory problems as mammals...
  35. DIFFERENTIATION OF SEXUAL BEHAVIOR
    Michael Baum; Fiscal Year: 2001
    ..The central hypothesis to be tested is that the processing of volatile odors, arising from sexually active conspecifics, by neurons located in different segments of the main olfactory ..
  36. Contribution of Estradiol to Female Neural Development
    Michael Baum; Fiscal Year: 2009
    ..the outcome of Aim 1 will reverse adult deficits (previously seen in ArKO females) in the investigation of urinary odors and in sexual behavior...