Research Topics
Genomes and Genes | odorsSummarySummary: The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed) Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Sensing odorants and pheromones with chemosensory receptorsKazushige Touhara
Department of Integrated Biosciences, The University of Tokyo, Chiba, 277 8562 Japan
Annu Rev Physiol 71:307-32. 2009..We review recent progress on chemosensory receptor structure, function, and circuitry in vertebrates and invertebrates from the point of view of the molecular biology and physiology of these sensory systems...
Odorant reception in the malaria mosquito Anopheles gambiaeAllison F Carey
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Nature 464:66-71. 2010..Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria...
Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odorsAjai Vyas
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:6442-7. 2007..In mice and rats, latent Toxoplasma infection converted the aversion to feline odors into attraction...
Select Drosophila glomeruli mediate innate olfactory attraction and aversionJulia L Semmelhack
Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
Nature 459:218-23. 2009..Together, these results indicate that individual glomeruli, rather than the entire pattern of active glomeruli, mediate innate behavioural output...
Characterization and coding of behaviorally significant odor mixturesJeffrey A Riffell
University of Arizona, Tucson, 85721, USA
Curr Biol 19:335-40. 2009..Surprisingly, how the olfactory system maintains identity of complex odors is unclear [6-10]...
Information processing in the mammalian olfactory systemPierre Marie Lledo
Laboratory of Perception and Memory, Pasteur Institute, Paris, France
Physiol Rev 85:281-317. 2005..Recent observations supporting the necessity of such plasticity for adult brain functions are also discussed. Due to space constraints, this review focuses mainly on the olfactory systems of vertebrates, and primarily those of mammals...
Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor codingR Jason Pitts
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA
BMC Genomics 12:271. 2011..gambiae...
The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulusA Vyas
Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
Neuroscience 148:342-8. 2007..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor...
Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiaeTan Lu
Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
Curr Biol 17:1533-44. 2007..However, the molecular and cellular basis of such olfactory responses remains largely unknown...
Insect olfactory receptors are heteromeric ligand-gated ion channelsKoji Sato
Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
Nature 452:1002-6. 2008..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
Antennal lobe processing increases separability of odor mixture representations in the honeybeeNina Deisig
Research Centre for Animal Cognition UMR 5169, Universite de Toulouse, UPS, Toulouse, France
J Neurophysiol 103:2185-94. 2010..As a result, mixture representations become more separable in the olfactory space, thus allowing better differentiation among floral blends in nature...
Maps of odorant molecular features in the Mammalian olfactory bulbKensaku Mori
Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Physiol Rev 86:409-33. 2006..The molecular-feature maps provide a basis for understanding how the olfactory cortex reads the odor maps of the OB...
Chemotopic odorant coding in a mammalian olfactory systemBrett A Johnson
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4550, USA
J Comp Neurol 503:1-34. 2007..A critical analysis suggests that alternative coding mechanisms for odor quality, such as those based on temporal patterns of responses, enjoy little experimental support...
Neural systems underlying decisions about affective odorsEdmund T Rolls
Oxford Centre for Computational Neuroscience, Oxford, UK via e mail
J Cogn Neurosci 22:1069-82. 2010..In an fMRI study, we delivered two odors separated by a delay, with instructions on different trials to decide which odor was more pleasant or more intense ..
Induction of cAMP response element-binding protein-dependent medium-term memory by appetitive gustatory reinforcement in Drosophila larvaeKen Honjo
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
J Neurosci 25:7905-13. 2005..Moreover, we also show that synaptic output of larval mushroom body neurons is required for retrieval but not for acquisition and retention of the larval memory, including the CREB-dependent component...
The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologsFabio Papes
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell 141:692-703. 2010..Neurons that sense these stimuli remain unknown. Here we show that detection and processing of fear-evoking odors emitted from cat, rat, and snake require the function of sensory neurons in the vomeronasal organ...
Odor cues during slow-wave sleep prompt declarative memory consolidationBjörn Rasch
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160 23a, 23538 Lubeck, Germany
Science 315:1426-9. 2007..Concurring with these findings, functional magnetic resonance imaging revealed significant hippocampal activation in response to odor re-exposure during SWS...
Neural correlates of behavior in the moth Manduca sexta in response to complex odorsJeffrey A Riffell
Department of Neuroscience, University of Arizona, Tucson AZ 85721 0077, USA
Proc Natl Acad Sci U S A 106:19219-26. 2009..to mixtures of varying behavioral effectiveness, we analyzed the coding of behaviorally "meaningful" odors. We considered four possible ensemble-coding mechanisms--mean firing rate, mean instantaneous firing rate, pattern ..
Ability of honeybee, Apis mellifera, to detect and discriminate odors of varieties of canola (Brassica rapa and Brassica napus) and snapdragon flowers (Antirrhinum majus)Geraldine A Wright
Department of Entomology, Ohio State University, Columbus 43210-1220, USA
J Chem Ecol 28:721-40. 2002Honeybees (Apis mellifera) use odors to identify and discriminate among flowers during foraging...
Odor quality coding and categorization in human posterior piriform cortexJames D Howard
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Nat Neurosci 12:932-8. 2009..These findings substantiate theoretical models emphasizing the importance of distributed piriform templates for the perceptual reconstruction of odor object quality...
Predatory mite attraction to herbivore-induced plant odors is not a consequence of attraction to individual herbivore-induced plant volatilesMichiel van Wijk
Institute for Biodiversity and Ecosystem Dynamics, 1090 GB, Amsterdam, The Netherlands
J Chem Ecol 34:791-803. 2008..However, upon associating each of these odors with food over a period of 15 min, both are preferred. The memory to this association wanes within 24 hr...
A metric for odorant comparisonRafi Haddad
Department of Neurobiology, Weizmann Institute of Science, Hertzel, Rehovot 76100 Israel
Nat Methods 5:425-9. 2008..We use this new metric to recommend sets of odorants that span the physicochemical space for use in olfaction experiments...
Lateral presynaptic inhibition mediates gain control in an olfactory circuitShawn R Olsen
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 452:956-60. 2008..A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal...
Is there a space-time continuum in olfaction?Michael Leon
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697 4550, USA
Cell Mol Life Sci 66:2135-50. 2009..olfactory sensory neurons respond differentially to airborne chemicals to initiate the process by which specific odors are perceived...
Associative conditioning tunes transient dynamics of early olfactory processingPatricia C Fernandez
Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
J Neurosci 29:10191-202. 2009b>Odors evoke complex spatiotemporal responses in the insect antennal lobe (AL) and mammalian olfactory bulb. However, the behavioral relevance of spatiotemporal coding remains unclear...
Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult miceFrancoise Lazarini
Institut Pasteur, Laboratory for Perception and Memory, Paris, France
PLoS ONE 4:e7017. 2009..Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear...
Aversive learning enhances perceptual and cortical discrimination of indiscriminable odor cuesWen Li
Cognitive Neurology and Alzheimer s Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Science 319:1842-5. 2008..That completely indiscriminable sensations can be transformed into discriminable percepts further accentuates the potency of associative learning to enhance sensory cue perception and support adaptive behavior...
The sniff as a unit of olfactory processingAdam Kepecs
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
Chem Senses 31:167-79. 2006..Recent behavioral experiments show that using a single sniff rats can accurately discriminate between very similar odors and fail to improve their accuracy by taking multiple sniffs...
Dynamic ensemble odor coding in the mammalian olfactory bulb: sensory information at different timescalesBrice Bathellier
Flavour Perception Group, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, CH 1015, Switzerland
Neuron 57:586-98. 2008..Based on this activity, almost optimal discrimination of presented odors was possible during single sniffs, consistent with reported behavioral data...
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channelsDieter Wicher
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
Nature 452:1007-11. 2008..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
Component information is preserved in glomerular responses to binary odor mixtures in the moth Spodoptera littoralisMikael A Carlsson
Department of Safety Pharmacology, AstraZeneca R and D Sodertalje, SE 151 85 Södertälje, Sweden
Chem Senses 32:433-43. 2007Natural odors are often complex mixtures of different compounds. These mixtures can be perceived to have qualities that are different from their components...
The olfactory bulb: coding and processing of odor molecule informationK Mori
Laboratory for Neuronal Recognition Molecules, Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
Science 286:711-5. 1999..They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex...
A resting box for outdoor sampling of adult Anopheles arabiensis in rice irrigation schemes of lower Moshi, northern TanzaniaEliningaya J Kweka
Tropical Pesticides Research Institute, Division of Livestock and Human Diseases Vector Control, Arusha, Tanzania
Malar J 8:82. 2009..In this study, human landing catch, two cow odour baited resting boxes and an unbaited resting box were evaluated as vector sampling tools in an area with a high proportion of Anopheles arabiensis, as the major malaria vector...
Diversity of odorant-binding proteins and chemosensory proteins in insectsPaolo Pelosi
University of Pisa, Pisa, Italy and China Agricultural University, Beijing, China
Chem Senses 30:i291-2. 2005
Mixture interactions in moth olfactory physiology: examining the effects of odorant mixture, concentration, distal stimulation, and antennal nerve transection on sensillar responsesN K Hillier
Department of Biology, Acadia University, Wolfville, Nova Scotia B4P2R6, Canada
Chem Senses 36:93-108. 2011..virescens ORNs...
A novel multicomponent stimulus device for use in olfactory experimentsShannon B Olsson
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knoell Strasse 8, Jena, Germany
J Neurosci Methods 195:1-9. 2011..multicomponent stimulus system for use in olfactory experiments that is capable of presenting up to 8 different odors simultaneously or in sequence at defined concentrations and time scales...
A circuit supporting concentration-invariant odor perception in DrosophilaKenta Asahina
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
J Biol 8:9. 2009Most odors are perceived to have the same quality over a large concentration range, but the neural mechanisms that permit concentration-invariant olfactory perception are unknown...
Intrinsic and circuit properties favor coincidence detection for decoding oscillatory inputJavier Perez-Orive
Computation and Neural Systems, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 24:6037-47. 2004..Finally, we find that a decoding strategy that is based on coincidence detection enhances both noise tolerance and input discriminability by KCs...
Toxoplasma gondii strain-dependent effects on mouse behaviourGeetha Kannan
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5371, USA
Folia Parasitol (Praha) 57:151-5. 2010..No differences in parasite antibody titres were seen between PRU- and ME49-infected mice. The present data suggest the effect of T. gondii infection on mouse behaviour is parasite strain-dependent...
Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiaeGuirong Wang
Department of Biological Sciences, Center for Molecular Neuroscience, Institutes of Chemical Biology and Global Health, Vanderbilt University, Nashville, TN 37235, USA
Proc Natl Acad Sci U S A 107:4418-23. 2010..gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases...
Synaptic inhibition in the olfactory bulb accelerates odor discrimination in miceNixon M Abraham
Institute of Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany WIN Olfactory Dynamics Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Neuron 65:399-411. 2010..cells via granule cells may contribute to odor discrimination behavior by refining neuronal representations of odors. Here we show that selective deletion of the AMPA receptor subunit GluA2 in granule cells boosted synaptic Ca(2+) ..
Predicting odor pleasantness from odorant structure: pleasantness as a reflection of the physical worldRehan M Khan
Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, Berkeley, California 94720, USA
J Neurosci 27:10015-23. 2007..However, our findings suggest that olfactory pleasantness is also partially innate, corresponding to a natural axis of maximal discriminability among biologically relevant molecules...
Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromonesFuqiang Xu
Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA
J Comp Neurol 489:491-500. 2005It is generally believed that the main olfactory system processes common odors and the accessory olfactory system is specifically for pheromones...
Medial amygdala modulation of predator odor-induced unconditioned fear in the ratChun-I Li
Psychobiology Laboratory, University of Hawaii, Honolulu, HI 96822, USA
Behav Neurosci 118:324-32. 2004..Furthermore, MeA lesions did not alter olfactory function and general locomotor activity. Results demonstrate that the MeA plays a major role in modulating predator odor-induced unconditioned fear...
Patterns of spontaneous activity in single rat olfactory receptor neurons are different in normally breathing and tracheotomized animalsPatricia Duchamp-Viret
, , CNRS UMR 5020, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
J Neurobiol 65:97-114. 2005..It is suggested that spontaneous activity may be modulated by respiration. Because natural sampling of odors is synchronized with breathing, such modulation may prepare and keep olfactory bulb circuits tuned to process odor ..
Attention to odor modulates thalamocortical connectivity in the human brainJane Plailly
Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Neurosci 28:5257-67. 2008..The results imply that olfaction, like all other sensory modalities, requires a thalamic relay, if only to consciously analyze a smell...
Neural and behavioral mechanisms of olfactory perceptionRachel I Wilson
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, United States
Curr Opin Neurobiol 18:408-12. 2008..Other recent studies highlight the role of active sensing (sniffing) in shaping odor-evoked neural activity and perception...
Differential dynamics of amino acid release in the amygdala and olfactory cortex during odor fear acquisition as revealed with simultaneous high temporal resolution microdialysisChloé Hegoburu
Neurosciences Sensorielles, Comportement, Cognition, CNRS UMR 5020, Universite de Lyon, Lyon, France
Learn Mem 16:687-97. 2009..In addition, our data raise the challenging idea that the olfactory cortex might store certain aspects of fear conditioning related to the timing of the associations...
Behavioral and neurophysiological responses of an insect to changing ratios of constituents in host plant-derived volatile mixturesA J Najar-Rodriguez
ETH Zurich, Institute of Plant, Animal and Agroecosystem Sciences Applied Entomology, Schmelzbergstrasse 9 LFO, 8092 Zurich, Switzerland
J Exp Biol 213:3388-97. 2010Ratios of compounds in host plant odors fluctuate with the phenological stage of the plant...
Functional connectivity and selective odor responses of excitatory local interneurons in Drosophila antennal lobeJu Huang
Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Neuron 67:1021-33. 2010..Furthermore, each eLN responded with distinct patterns to different odors, and each odor elicited distinct responses in different eLNs, with specific temporal patterns of spiking, ..
Neural encoding of rapidly fluctuating odorsMaria N Geffen
Program in Biophysics, Harvard University, Cambridge, MA 02138, USA
Neuron 61:570-86. 2009..The responses varied greatly across PNs and across odors for the same PN...
Transformation of odor representations in target areas of the olfactory bulbEmre Yaksi
Max Planck Institute for Medical Research, Heidelberg, Germany
Nat Neurosci 12:474-82. 2009..Responses to different odors and their mixtures indicate that Vv neurons pool convergent inputs, resulting in broadened tuning curves and ..
Activational rather than navigational effects of odors on homing of young pigeonsPaulo E Jorge
Centro de Biologia Ambiental, Museu Nacional de Historia Natural, Universidade de Lisboa, Lisboa, Portugal
Curr Biol 19:650-4. 2009..The most common procedure used to investigate the role of odors in avian homing is to experimentally produce anosmia and/or block access to natural odors [4, 5]...
Beyond nature and nurture: phenotypic plasticity in blood-feeding behavior of Anopheles gambiae s.s. when humans are not readily accessibleThierry Lefevre
Génétique et Evolution des Maladies Infectieuses, Montpellier, France
Am J Trop Med Hyg 81:1023-9. 2009..This paradox can be interpreted as the evolution of a plastic strategy of feeding behavior in this field population of An. gambiae because of the greater accessibility of readily available, although less-preferred, hosts...
Long-term memory shapes the primary olfactory center of an insect brainBenoît Hourcade
Research Centre on Animal Cognition, CNRS, University Paul Sabatier UMR 5169, 31062 Toulouse Cedex 04, France
Learn Mem 16:607-15. 2009..We have therefore focused on associative memories of individual odors and the possible related changes in the honeybee primary olfactory center, the antennal lobe (AL)...
Characterization of an antennal carboxylesterase from the pest moth Spodoptera littoralis degrading a host plant odorantNicolas Durand
UMR A 1272 UPMC INRA Physiologie de l Insecte, Université Pierre et Marie Curie and INRA, Paris and Versailles, France
PLoS ONE 5:e15026. 2010..These enzymes are only expressed in the male antennae, and secreted into the lumen of the pheromone-sensitive sensilla. CCEs able to hydrolyze other odorants than sex pheromones, such as plant volatiles, have not been identified...
Prospects for developing odour baits to control Glossina fuscipes spp., the major vector of human African trypanosomiasisMaurice O Omolo
International Center for Insect Physiology and Ecology, ICIPE, Nairobi, Kenya
PLoS Negl Trop Dis 3:e435. 2009..The results suggest that identifying kairomones present in lizard odour for G. f. fuscipes and pig odour for G. f. quanzensis may improve the performance of targets for controlling these species...
Temporally diverse firing patterns in olfactory receptor neurons underlie spatiotemporal neural codes for odorsBaranidharan Raman
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:1994-2006. 2010..How then are dynamic neural codes for odors generated? Consistent with recent results from several other species, our recordings from locust ORNs showed a ..
Central processing of natural odor mixtures in insectsHong Lei
ARL Neurobiology, University of Arizona, Tucson, AZ 85721, USA
J Chem Ecol 34:915-27. 2008..The difference between these two types of processing may reside in the degree of plasticity, with the former being hard-wired and the latter being more subjected to network modulation...
Functional architecture of olfactory ionotropic glutamate receptorsLiliane Abuin
Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
Neuron 69:44-60. 2011..Our results provide insights into the conserved and distinct architecture of these olfactory and synaptic ion channels and offer perspectives into the use of IRs as genetically encoded chemical sensors. VIDEO ABSTRACT:..
Rapid decision-making with side-specific perceptual discrimination in antsNathalie Stroeymeyt
Department of Biology, Centre for Social Evolution, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 5:e12377. 2010..In mammals, there is mounting evidence that multiple systems of perceptual discrimination based on different neural circuits emphasize either fast responses or accurate treatment of stimuli depending on the context...
Bulbar acetylcholine enhances neural and perceptual odor discriminationDipesh Chaudhury
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14850, USA
J Neurosci 29:52-60. 2009..These results together present a first direct comparison between neural and perceptual effects of a bulbar neuromodulator...
Calcium current diversity in physiologically different local interneuron types of the antennal lobeAndreas Husch
Institute of Zoology and Physiology, Center for Molecular Medicine Cologne, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany
J Neurosci 29:716-26. 2009..These marked physiological differences between the two LN types imply consequences for their computational capacity, synaptic output kinetics, and thus their function in the olfactory circuit...
Distinct patterns of olfactory impairment in Alzheimer's disease, semantic dementia, frontotemporal dementia, and corticobasal degenerationSimona Luzzi
Department of Neuroscience, University of Ancona, Italy
Neuropsychologia 45:1823-31. 2007..The findings add further insights into the nature of the semantic deficit in SD by exploring a hitherto neglected modality and may have relevance in explaining the altered eating habits commonly associated with SD...
The feeling of familiarity of music and odors: the same neural signature?Jane Plailly
Neurosciences and Systèmes Sensoriels, Universite Claude Bernard Lyon 1, UMR CNRS 5020, IFR 19, Institut Federatif des Neurosciences de Lyon, 69366, Lyon Cedex 07, France
Cereb Cortex 17:2650-8. 2007..the present experiment, we investigated this hypothesis by studying the neural bases of familiarity processing of odors and music. In particular, we focused on familiarity referring to the participants' life experience...
Local and global chemotopic organization: general features of the glomerular representations of aliphatic odorants differing in carbon numberBrett A Johnson
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4550, USA
J Comp Neurol 480:234-49. 2004..Thus, global chemotopy and local modular chemotopy appear to be fundamental principles underlying the representation of odorants differing in carbon chain length...
Coding of odors by a receptor repertoireElissa A Hallem
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Cell 125:143-60. 2006..We test the receptors with a panel of over 100 odors and find that strong responses are sparse, with response density dependent on chemical class...
Minimal olfactory perception during sleep: why odor alarms will not work for humansMary A Carskadon
Department of Psychiatry and Human Behavior, Sleep Research Laboratory, Brown Medical School Bradley Hospital, Providence, RI 02906, USA
Sleep 27:402-5. 2004..To examine olfactory arousal threshold during sleep in comparison to an auditory tone...
Olfactory maps and odor imagesSigrun Korsching
Institut fur Genetik, Universitat zu Koln, 50674, Koln, Germany
Curr Opin Neurobiol 12:387-92. 2002..Modifications of the glomerular odor map have resulted in altered percepts of the corresponding odors.
A computational model of the response of honey bee antennal lobe circuitry to odor mixtures: overshadowing, blocking and unblocking can arise from lateral inhibitionC Linster
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Behav Brain Res 87:1-14. 1997..These results provide testable hypotheses that will guide future behavioral and physiological analyses...
Contrast enhancement of stimulus intermittency in a primary olfactory network and its behavioral significanceHong Lei
University of Arizona, Tucson, 85721 0077, USA
J Biol 8:21. 2009....
Experimental psychology: event timing turns punishment to rewardHiromu Tanimoto
Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
Nature 430:983. 2004..These opposing behaviours depend on the relative timing of the shock and odour presentations during training, and indicate that a shock can act as either an aversive reinforcer or an appetitive one...
Characterization of the aroma-active compounds in pink guava (Psidium guajava, L.) by application of the aroma extract dilution analysisMartin Steinhaus
Deutsche Forschungsanstalt fur Lebensmittelchemie, Lichtenbergstrasse 4, D 85748 Garching, Germany
J Agric Food Chem 56:4120-7. 2008..Seven odorants were identified for the first time in guavas, among them 3-sulfanylhexyl acetate, 3-sulfanyl-1-hexanol, 3-hydroxy-4,5-dimethyl-2(5 H)-furanone, trans-4,5-epoxy-( E)-2-decenal, and methional were the most odor-active...
Influence of rearing conditions on the volatile compounds of cooked fillets of Silurus glanis (European catfish)Arnaud Hallier
Food Aroma Quality Research, ENITIAA, rue de la Geraudiere, BP 82225 44322 Nantes, France
J Agric Food Chem 53:7204-11. 2005..Boiled potato sensory odor of the silurus cooked fillets can be related to (Z)-4-heptenal and methional, and buttery odor can be related to 2,3-butanedione, an unknown compound (RI = 1010), and 2,3-pentadione...
Characterization of odor-active volatiles in champa (Campomanesia lineatifolia R. and P.)Coralia Osorio
Departamento de Química and Instituto de Ciencias Naturales, Universidad Nacional de Colombia, AA14490 Bogotá, Colombia
J Agric Food Chem 54:509-16. 2006..This is the first time that the volatile composition in champa is reported and also the sensory odor importance of beta-triketones...
Characterization of dried whey protein concentrate and isolate flavorM E Carunchia Whetstine
Department of Food Science, Southeast Dairy Foods Research Center, North Carolina State University, Raleigh 27695, USA
J Dairy Sci 88:3826-39. 2005....
Correlation between the pattern volatiles and the overall aroma of wild edible mushroomsP Guedes De Pinho
REQUI MTE Serviço de Farmacognosia, Faculdade de Farmacia da Universidade do Porto, R Aníbal Cunha 164, 4050 047 Porto, Portugal
J Agric Food Chem 56:1704-12. 2008..The presence and contents of these compounds give a considerable contribution to the sensory characteristics of the analyzed species...
Identification of characteristic aroma-active compounds from water dropwort (Oenanthe javanica DC.)Won Ho Seo
Department of Food Engineering, Dankook University, Cheonan 330 714, Korea
J Agric Food Chem 53:6766-70. 2005..The aroma property of p-cymene was dependent on its concentration and was described as kerosene-like at relatively high concentrations but changed to citrus and green aroma notes at low concentrations...
Flavor profiles of full-fat and reduced-fat cheese and cheese fat made from aged Cheddar with the fat removed using a novel processM E Carunchia Whetstine
Department of Food Science, Southeast Dairy Foods Research Center, North Carolina State University, Raleigh 27695, USA
J Dairy Sci 89:505-17. 2006..This study demonstrated that when fat was removed from aged full-fat Cheddar cheese, most of the flavor and flavor compounds remained in the cheese and were not removed with the fat...
Identification of components responsible for the odor of cigar smoker's breathRussell Bazemore
Wm. Wrigley Jr. Co, 1132 West Blackhawk Street, Chicago, Illinois 60622, USA
J Agric Food Chem 54:497-501. 2006..Pyridines and pyrazines, the most prominent classes of odorous compounds identified in this experiment, may be generated during cigar pyrrolysis by cleavage of nicotine or by Maillard reaction...
Reproducibility of odor maps by fMRI in rodentsJames R Schafer
Department of Neurobiology, Magnetic Resonance Research Center, Yale University, New Haven, CT 06510, USA
Neuroimage 31:1238-46. 2006..These results demonstrate the robustness of high-field fMRI as a tool for assaying olfactory bulb function and provide evidence that equivalent perceptual outcomes may arise from divergent neural substrates...
Identification of volatile compounds responsible for prune aroma in prematurely aged red winesAlexandre Pons
R and D Division, Seguin Moreau SA, Z I Merpins, B P 94, 16103 Cognac, France
J Agric Food Chem 56:5285-90. 2008..The presence of 3-methyl-2,4-nonanedione was also detected in prunes for the first time...
Odor-active compounds in cooked rice cultivars from Camargue (France) analyzed by GC-O and GC-MSIsabelle Maraval
UMR Qualisud, CIRAD, 73 Rue J F Breton, Montpellier F 34398, France
J Agric Food Chem 56:5291-8. 2008..Hierarchical cluster analysis showed that most of the difference between rice odors was linked to quantitative differences with only 11 compounds being specific to some of the rice...
Influence of the addition of raspberry seed extract on changes in the volatile pattern of stored model breakfast cerealDorota Klensporf
Department of Food Science and Nutrition, The August Cieszkowski Agricultural University of Poznan, Wojska Polskiego 31, 60 624 Poznan, Poland
J Agric Food Chem 56:3268-72. 2008..The flavor dilution factor (FD) values for volatile lipid oxidation products were lower in samples with red raspberry seed extract added...
Synergistic mixture interactions in detection of perithreshold odors by humansToshio Miyazawa
Flavor System and Technology Laboratory, R and D Control Division, Ogawa and Co Ltd, 15 7 Chidori Urayashu shi, Chiba 279 0032, Japan
Chem Senses 33:363-9. 2008....
Antennal and behavioral responses of Cis boleti to fungal odor of Trametes gibbosaProdpran Thakeow
Institute of Forest Zoology and Forest Conservation, University of Gottingen, 37077 Gottingen, Germany
Chem Senses 33:379-87. 2008..Female beetles were significantly attracted to the (S)-(+)- enantiomer at 10 times lower doses than male beetles. Our finding is the first direct proof that ciid beetles use 1-octen-3-ol as a key cue for host finding...
Stereoselective formation of the varietal aroma compound rose oxide during alcoholic fermentationStephan Koslitz
University of Applied Sciences Western Switzerland Valais, Department of Life Technologies, Sion, Switzerland
J Agric Food Chem 56:1371-5. 2008..This observation corroborates recent findings that the modification of terpene derived varietal aroma is an integral part of yeast metabolism and not only a simple hydrolytical process...
Characterization of volatile aroma compounds in cooked black riceDong Sik Yang
University of Georgia, Plant Sciences Bldg, Athens, GA 30602 7273, USA
J Agric Food Chem 56:235-40. 2008..2-AP and guaiacol were major contributors to the unique character of black rice based on odor thresholds, relative concentrations, and olfactometry...
Characterization of steam volatiles in the essential oil of black currant buds and the antioxidant properties of different bud extractsAsta Dvaranauskaite
Kaunas University of Technology, Radvilenu pl 19, LT 50254, Kaunas, Lithuania
J Agric Food Chem 56:3279-86. 2008..The total amount of phenolic compounds expressed in gallic acid equivalents in FDWF varied in the range of 132-192 mg/g; in SDWF, 140-209 mg/g; in AE, 49-107 mg/g; and in ME extracts, 111-180 mg/g...
In vitro and in vivo release of aroma compounds from yellow-fleshed kiwifruitEllen N Friel
HortResearch, Mount Albert Research Centre, Private Bag 92169, Auckland, New Zealand
J Agric Food Chem 55:6664-73. 2007..There were a number of similarities between the breath profiles of the two panelists, which confirmed the importance of DMS in "Hort16A" aroma...
Comparison of three lychee cultivar odor profiles using gas chromatography-olfactometry and gas chromatography-sulfur detectionKanjana Mahattanatawee
Institute of Food and Agricultural Sciences, Citrus Research and Education Center, University of Florida, 700 Experiment Station Road, Lake Alfred, Florida 33850, USA
J Agric Food Chem 55:1939-44. 2007....
Comparison of the amounts of volatile compounds in French protected designation of origin virgin olive oilsBenoit Berlioz
LCMBA, UMR CNRS 6001, , Parc Valrose, F-06108 Nice Cedex 2, France
J Agric Food Chem 54:10092-101. 2006..PCA and SIMCA of chromatographic data were related to sensory analysis and led to a better understanding of the chemical features and observed sensory effects of olive oils...
Identification of the volatile component(s) causing the characteristic foxy odor in various cultivars of Fritillaria imperialis L. (Liliaceae)Johannes Petrus Franciscus Gerardus Helsper
Plant Research International PRI DLO, P O Box 16, and Agrotechnology and Food Innovations A and F DLO, P O Box 17, 6700 AA Wageningen, The Netherlands
J Agric Food Chem 54:5087-91. 2006..Chemical identification was substantiated by GC-O and GC-MS of an authentic standard of 3-methyl-2-butene-1-thiol, prepared by organic synthesis...
Characterization of epoxydecenal isomers as potent odorants in black tea (Dimbula) infusionKenji Kumazawa
Ogawa and Company, Ltd, 15 7 Chidori Urayasushi, Chiba 279 0032, Japan
J Agric Food Chem 54:4795-801. 2006....
Sniffing controls an adaptive filter of sensory input to the olfactory bulbJustus V Verhagen
Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
Nat Neurosci 10:631-9. 2007..Mammals sample odors by sniffing, a complex behavior that controls odorant access to receptor neurons...
Comparison of aroma volatiles in commercial Merlot and Cabernet Sauvignon wines using gas chromatography-olfactometry and gas chromatography-mass spectrometryOzan Gurbuz
Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, Florida 33850, USA
J Agric Food Chem 54:3990-6. 2006..Merlot wines from both Australia and California contained 4-5 times more ethyl octanoate than Cabernet Sauvignon wines from the same sources...
Studies on the aroma of five fresh tomato cultivars and the precursors of cis- and trans-4,5-epoxy-(E)-2-decenals and methionalFlorian Mayer
Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA
J Agric Food Chem 56:3749-57. 2008..To help elucidate formation pathways of key odorants, labeled precursors were added to tomatoes. Biogenesis of cis- and trans-4,5-epoxy-( E)-2-decenals from linoleic acid and methional from methionine was confirmed...
Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extractionM Consuelo Díaz-Maroto
Area de Tecnologia de los Alimentos, Facultad de Ciencias Quimicas, Universidad de Castilla La Mancha, Ciudad Real, Spain
J Agric Food Chem 53:5385-9. 2005..Thymol and carvacrol, with oregano, thyme, and spicy notes, were identified as key compounds contributing to the aroma of thyme leaves...
Odorants generated by thermally induced degradation of phospholipidsJianming Lin
Nestec Ltd, , Vers-chez-les-Blanc, P.O. Box 44, CH-1000 Lausanne 26, Switzerland
J Agric Food Chem 51:4364-9. 2003....
Detection of fruit- and flower-emitted volatiles by olfactory receptor neurons in the polyphagous fruit chafer Pachnoda marginata (Coleoptera: Cetoniinae)M C Stensmyr
Department of Ecology, Lund University, Sweden
J Comp Physiol A 187:509-19. 2001..The results support the growing hypothesis that a significant proportion of plant-odor receptor neurons in insects are highly sensitive and selective for single odors.
Comparison of two microalgal diets. 2. Influence on odorant composition and organoleptic qualities of raw oysters (Crassostrea gigas)Anne Laure Pennarun
Laboratoire de Biochimie Alimentaire et Industrielle, Ecole Nationale des Ingénieurs des Techniques des Industries Agro Alimentaire, rue de la Geraudiere, B P 82225, 44322 Nantes Cedex 3, France
J Agric Food Chem 51:2011-8. 2003..Moreover, the organoleptic qualities (odor, taste, and texture) of oysters are modified by the diet of microalgae...
Research Grants
- BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTIONBrian Smith; Fiscal Year: 2007..honeybee (Apis mellifera) as a model animal species for understanding mechanisms of behavioral plasticity toward odors. These animals are faced with the same types of olfactory problems as mammals...
- Molecular basis of olfactory perception.DAVID NIGEL JONES; Fiscal Year: 2010..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
- Disruption of Host-Seeking Behavior in Aedes and Culex Mosquitoes using OdorantsAnandasankar Ray; Fiscal Year: 2010..identify their human hosts primarily using olfactory cues like carbon dioxide in exhaled breath, as well as other odors present in skin emanations...
- Olfactory Circuits for Reproduction and RewardJames A Cherry; Fiscal Year: 2010..Moreover, despite evidence in animals that such biologically relevant odors may act as natural rewards, the routes through which odors are conveyed to the mesolimbic dopamine system that ..
- Olfactory Circuits for Reproduction and RewardJames A Cherry; Fiscal Year: 2011..Moreover, despite evidence in animals that such biologically relevant odors may act as natural rewards, the routes through which odors are conveyed to the mesolimbic dopamine system that ..
- Multiple Mechanisms of Nasal ChemoreceptionDIEGO contact RESTREPO; Fiscal Year: 2010..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006;Buck, 2005;Lin et al., 2007;Lin et al., 2004)...
- Multiple Mechanisms of Nasal ChemoreceptionDiego Restrepo; Fiscal Year: 2009..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006; Buck, 2005; Lin et al., 2007; Lin et al., 2004)...
- Multiple Mechanisms of Nasal ChemoreceptionDiego Restrepo; Fiscal Year: 2009..the main olfactory epithelium also appears to be involved in detecting pheromones and other semiochemicals - odors involved in animal communication (Baxi et al., 2006; Buck, 2005; Lin et al., 2007; Lin et al., 2004)...
- MECHANISMS OF OLFACTORY TRANSDUCTIONJohn Teeter; Fiscal Year: 2003..our overall quality of life is becoming increasingly appreciated with advances in our understanding of how odors influence the enjoyment of food and beverages and our sense of well-being...
- Parasite / host interaction and the neurobiology of fearRobert M Sapolsky; Fiscal Year: 2010..evolved the capacity to, once having formed cysts in the brain, abolish the innate fear that rodents have of the odors of cats, and to convert that fear into an attraction;this increases the likelihood of the rodent being predated, ..
- Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory NAlbert Folch; Fiscal Year: 2009..to characterize the dynamics and the specificity of the responses of OSNs to a large variety of odorants, complex odors, and pheromones...
- Parasite / host interaction and the neurobiology of fearRobert Sapolsky; Fiscal Year: 2009..evolved the capacity to, once having formed cysts in the brain, abolish the innate fear that rodents have of the odors of cats, and to convert that fear into an attraction; this increases the likelihood of the rodent being predated, ..
- Implementation of Microfluidic Automation for Large-Scale Searches of Olfactory NAlbert Folch; Fiscal Year: 2010..to characterize the dynamics and the specificity of the responses of OSNs to a large variety of odorants, complex odors, and pheromones...
- INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULIRuth Wood; Fiscal Year: 2003..Castration also reduces sexual motivation, as measured by interest in vaginal odors and preference for a receptive female...
- INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULIRuth Wood; Fiscal Year: 2006..Castration also reduces sexual motivation, as measured by interest in vaginal odors and preference for a receptive female...
- Molecular mechanisms of olfaction in mammalsLinda B Buck; Fiscal Year: 2011..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
- Molecular mechanisms of olfaction in mammalsLinda Buck; Fiscal Year: 2009..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
- Molecular mechanisms of olfaction in mammalsLinda Buck; Fiscal Year: 2009..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
- Molecular mechanisms of olfaction in mammalsLinda B Buck; Fiscal Year: 2010..information to yet other brain areas involved in odor perception and the emotional and physiological effects of odors. Odorant detection in mice is mediated by ~1000 different odorant receptors (ORs), each expressed by a different ..
- Taste, smell, and feeding behavior in autism: A quantitative traits studyLoisa Bennetto; Fiscal Year: 2010..processing, there is considerable evidence that children with autism show unusual responses to tastes and odors, and we have recently documented autism-specific impairments in psychophysiological tests of taste and odor ..
- Taste, smell, and feeding behavior in autism: A quantitative traits studyLoisa Bennetto; Fiscal Year: 2009..processing, there is considerable evidence that children with autism show unusual responses to tastes and odors, and we have recently documented autism-specific impairments in psychophysiological tests of taste and odor ..
- Psychoneuroimmunology and Mind-Body MedicineJanice Kiecolt Glaser; Fiscal Year: 2005..This design will allow us to examine the ability of the odors to modulate autonomic, endocrine, and immune function, and health-relevant cutaneous responses...
- Contribution of Estradiol to Female Neural DevelopmentMichael Baum; Fiscal Year: 2006..no estradiol due to a targeted mutation in the aromatase gene, showed little interest in approaching volatile odors derived from conspecifics of either sex and showed low levels of sexual receptivity after adult treatment with ..
- MOLECULAR BASIS OF OLFACTORY DISCRIMINATIONLinda Buck; Fiscal Year: 2005..and discrimination of a vast number of structurally diverse odorants that are perceived as having different odors. On the other, it mediates the detection of pheromones, chemicals released from animals that stimulate ..
- Dynamics of glomerular coding in the olfactory bulbDALE M WACHOWIAK; Fiscal Year: 2010..by applicant): The goal of this research is to understand how the nervous system encodes information about odors. The sense of smell presents unique problems to the nervous system in terms of stimulus detection, neural encoding ..
- Dynamics of glomerular coding in the olfactory bulbDALE WACHOWIAK; Fiscal Year: 2009..by applicant): The goal of this research is to understand how the nervous system encodes information about odors. The sense of smell presents unique problems to the nervous system in terms of stimulus detection, neural encoding ..
- STRUCT/FUNCTIONAL GENOMICS OF OLFACTORY RECEPTOR GENESBarbara Trask; Fiscal Year: 2002Our ability to smell thousands of different odors is mediated by a large repertoire of odorant receptors (OR) expressed on sensory neurons in the nose. The Ors bind odorous molecules and transmit this information to the brain...
- Neural substrates of taste, smell and flavor in humansDANA SMALL; Fiscal Year: 2006..brain response in healthy human volunteer subjects to tastes presented in isolation and tastes presented with odors. The neural substrates of taste must code for three major perceptual dimensions of taste; namely, intensity, ..
- Unconventional receptor neurons in nasal epitheliaANNELOTTE HANSEN; Fiscal Year: 2007..The common view attributes ciliated receptor neurons to the main olfactory epithelium to detect mainly food odors and microvillus receptor neurons to the vomeronasal organ to detect sexual/social cues...
- Molecular basis of olfactory perception.David Jones; Fiscal Year: 2009..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
- Molecular basis of olfactory perception.David Jones; Fiscal Year: 2007..Female mosquitoes of the species Anopheles gambiae are feed almost exclusively on humans and use odors present in human sweat and skin to locate their targets and discriminate humans from other animals...
- GENETIC AND MOLECULAR ANALYSIS OF OLFACTIONJohn R Carlson; Fiscal Year: 2010..The behavior elicited by pairs of odors is then analyzed...
- Glycoconjugates in Cell Cell InteractionsGERALD SCHWARTING; Fiscal Year: 2005..Most mammalian species, including humans, have the ability to distinguish thousands of different odors. This ability is encoded in the organized connections made between olfactory sensory neurons in the nasal cavity ..
- BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTIONBrian Smith; Fiscal Year: 2009..honeybee (Apis mellifera) as a model animal species for understanding mechanisms of behavioral plasticity toward odors. These animals are faced with the same types of olfactory problems as mammals...
- DIFFERENTIATION OF SEXUAL BEHAVIORMichael Baum; Fiscal Year: 2001..The central hypothesis to be tested is that the processing of volatile odors, arising from sexually active conspecifics, by neurons located in different segments of the main olfactory ..
- Contribution of Estradiol to Female Neural DevelopmentMichael Baum; Fiscal Year: 2009..the outcome of Aim 1 will reverse adult deficits (previously seen in ArKO females) in the investigation of urinary odors and in sexual behavior...
