Top Publications

  1. ncbi Birdsong and anthropogenic noise: implications and applications for conservation
    Hans Slabbekoorn
    Institute of Biology, Leiden University, 2300 RA Leiden, The Netherlands
    Mol Ecol 17:72-83. 2008
  2. pmc Key role of coupling, delay, and noise in resting brain fluctuations
    Gustavo Deco
    Department of Computational Neuroscience, Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, Barcelona, Spain
    Proc Natl Acad Sci U S A 106:10302-7. 2009
  3. ncbi Musical experience limits the degradative effects of background noise on the neural processing of sound
    Alexandra Parbery-Clark
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 29:14100-7. 2009
  4. pmc Tuning out the noise: limbic-auditory interactions in tinnitus
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC 20057 1460, USA
    Neuron 66:819-26. 2010
  5. ncbi The quantitative relationship between road traffic noise and hypertension: a meta-analysis
    Elise van Kempen
    National Institute for Public Health and the Environment, Centre for Environmental Health Research, Bilthoven, The Netherlands
    J Hypertens 30:1075-86. 2012
  6. pmc Noise in the nervous system
    A Aldo Faisal
    Computational and Biological Learning Lab, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
    Nat Rev Neurosci 9:292-303. 2008
  7. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
  8. pmc Ringing ears: the neuroscience of tinnitus
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 30:14972-9. 2010
  9. ncbi Association of long-term exposure to community noise and traffic-related air pollution with coronary heart disease mortality
    Wen Qi Gan
    School of Population and Public Health, The University of British Columbia, Vancouver, Canada
    Am J Epidemiol 175:898-906. 2012
  10. ncbi The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006

Detail Information

Publications302 found, 100 shown here

  1. ncbi Birdsong and anthropogenic noise: implications and applications for conservation
    Hans Slabbekoorn
    Institute of Biology, Leiden University, 2300 RA Leiden, The Netherlands
    Mol Ecol 17:72-83. 2008
    ..activities all over the world has caused, on an evolutionary time scale, a sudden rise in especially low-pitched noise levels...
  2. pmc Key role of coupling, delay, and noise in resting brain fluctuations
    Gustavo Deco
    Department of Computational Neuroscience, Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, Barcelona, Spain
    Proc Natl Acad Sci U S A 106:10302-7. 2009
    ..In numerical simulation, we studied the dynamics of a simplified cortical network using 38 noise-driven (Wilson-Cowan) oscillators, which in isolation remain just below their oscillatory threshold...
  3. ncbi Musical experience limits the degradative effects of background noise on the neural processing of sound
    Alexandra Parbery-Clark
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 29:14100-7. 2009
    ..parsing melodies from background harmonies, which can be considered a process analogous to speech perception in noise. To investigate the effect of musical experience on the neural representation of speech-in-noise, we compared ..
  4. pmc Tuning out the noise: limbic-auditory interactions in tinnitus
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC 20057 1460, USA
    Neuron 66:819-26. 2010
    ..million people in the United States alone, and its incidence is rising due to an aging population and increasing noise exposure. Although several approaches for the alleviation of tinnitus exist, there is as of yet no cure...
  5. ncbi The quantitative relationship between road traffic noise and hypertension: a meta-analysis
    Elise van Kempen
    National Institute for Public Health and the Environment, Centre for Environmental Health Research, Bilthoven, The Netherlands
    J Hypertens 30:1075-86. 2012
    Reviews have suggested that road noise exposure is associated with high blood pressure (hypertension). No reliable exposure-response relationship is as yet available...
  6. pmc Noise in the nervous system
    A Aldo Faisal
    Computational and Biological Learning Lab, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, UK
    Nat Rev Neurosci 9:292-303. 2008
    b>Noise--random disturbances of signals--poses a fundamental problem for information processing and affects all aspects of nervous-system function...
  7. pmc Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss
    Sharon G Kujawa
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:14077-85. 2009
    ..Results suggest that noise-induced damage to the ear has progressive consequences that are considerably more widespread than are revealed by ..
  8. pmc Ringing ears: the neuroscience of tinnitus
    Larry E Roberts
    Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Neurosci 30:14972-9. 2010
    ..the frequency spectrum of tinnitus sounds, which are optimally suppressed following exposure to band-limited noise covering the same frequencies...
  9. ncbi Association of long-term exposure to community noise and traffic-related air pollution with coronary heart disease mortality
    Wen Qi Gan
    School of Population and Public Health, The University of British Columbia, Vancouver, Canada
    Am J Epidemiol 175:898-906. 2012
    ..areas, road traffic is a major contributor to ambient air pollution and the dominant source of community noise. The authors investigated the independent and joint influences of community noise and traffic-related air ..
  10. ncbi The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
    Modern research has provided new insights into the biological mechanisms of noise-induced hearing loss, and with these new insights comes hope for possible prevention or treatment...
  11. ncbi Aircraft noise, air pollution, and mortality from myocardial infarction
    Anke Huss
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Epidemiology 21:829-36. 2010
    Myocardial infarction has been associated with both transportation noise and air pollution. We examined residential exposure to aircraft noise and mortality from myocardial infarction, taking air pollution into account.
  12. pmc Hypertension and exposure to noise near airports: the HYENA study
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London, United Kingdom
    Environ Health Perspect 116:329-33. 2008
    An increasing number of people are exposed to aircraft and road traffic noise. Hypertension is an important risk factor for cardiovascular disease, and even a small contribution in risk from environmental factors may have a major impact ..
  13. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
    ..Two tests were applied: the Threshold Equalizing Noise (TEN) test and a pitch scaling task...
  14. ncbi Road traffic noise and cardiovascular risk
    Wolfgang Babisch
    Department of Environmental Hygiene, Federal Environment Agency, Germany
    Noise Health 10:27-33. 2008
    Studies on the association between community noise and cardiovascular risk were subjected to a meta-analysis for deriving a common dose-effect curve...
  15. pmc Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?
    Susanne Dehmel
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:1660-71. 2012
    ..nucleus stimulation are compared between normal-hearing animals and animals overexposed with narrow band noise and behaviorally tested for tinnitus...
  16. pmc Attention-driven auditory cortex short-term plasticity helps segregate relevant sounds from noise
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:4182-7. 2011
    ..To produce overlapping inputs, the tones were presented alone vs. during white-noise masking notch-filtered ±1/6 octaves around the tone center frequencies. Amplitude modulation (39 vs...
  17. pmc Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift
    Harrison W Lin
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 12:605-16. 2011
    ..This contrasts with earlier ultrastructural work in guinea pig suggesting that acute noise-induced neural degeneration is followed by full regeneration of cochlear nerve terminals in the IHC area (Puel et ..
  18. ncbi Efficient auditory coding
    Evan C Smith
    Department of Psychology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nature 439:978-82. 2006
    ..These results indicate that the auditory code might approach an information theoretic optimum and that the acoustic structure of speech might be adapted to the coding capacity of the mammalian auditory system...
  19. ncbi The benefits of noise in neural systems: bridging theory and experiment
    Mark D McDonnell
    The Computational and Theoretical Neuroscience Laboratory, Institute for Telecommunications Research, University of South Australia, Mawson Lakes, SA 5095, Australia
    Nat Rev Neurosci 12:415-26. 2011
    Although typically assumed to degrade performance, random fluctuations, or noise, can sometimes improve information processing in non-linear systems...
  20. ncbi A simple white noise analysis of neuronal light responses
    E J Chichilnisky
    Systems Neurobiology, The Salk Institute, La Jolla, CA 92037 1099, USA
    Network 12:199-213. 2001
    A white noise technique is presented for estimating the response properties of spiking visual system neurons. The technique is simple, robust, efficient and well suited to simultaneous recordings from multiple neurons...
  21. pmc Dorsal cochlear nucleus responses to somatosensory stimulation are enhanced after noise-induced hearing loss
    S E Shore
    Department of Otolaryngology, Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Eur J Neurosci 27:155-68. 2008
    ..of DCN neurons to trigeminal and bimodal (trigeminal plus acoustic) stimulation were compared in normal and noise-damaged guinea pigs...
  22. ncbi Clinical evaluation of signal-to-noise ratio-based noise reduction in Nucleus® cochlear implant recipients
    Pam W Dawson
    The HEARing Cooperative Research Centre, and 2Cochlear Limited, Melbourne, Victoria, Australia
    Ear Hear 32:382-90. 2011
    The aim of this study was to investigate whether a real-time noise reduction algorithm provided speech perception benefit for Cochlear™ Nucleus® cochlear implant recipients in the laboratory.
  23. ncbi Speech recognition in noise for cochlear implant listeners: benefits of residual acoustic hearing
    Christopher W Turner
    Dept of Speech Pathology and Audiology, Dept of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    J Acoust Soc Am 115:1729-35. 2004
    ..low-frequency residual acoustic hearing for speech recognition in a background of other talkers, but not in steady noise. Three subjects with an implanted "short-electrode" cochlear implant and preserved low-frequency ..
  24. pmc Single and combined effects of air, road, and rail traffic noise on sleep and recuperation
    Mathias Basner
    German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
    Sleep 34:11-23. 2011
    Traffic noise disturbs sleep and may impair recuperation. There is limited information on single and combined effects of air, road, and rail traffic noise on sleep and recuperation.
  25. pmc Cortical activity patterns predict robust speech discrimination ability in noise
    Jai A Shetake
    The University of Texas at Dallas, School of Behavioral Brain Sciences, 800 West Campbell Road, GR41 Richardson, TX 75080 3021, USA
    Eur J Neurosci 34:1823-38. 2011
    ..sound discrimination in rats and recorded primary auditory cortex (A1) responses to speech sounds in background noise of different intensities and spectral compositions...
  26. ncbi Random noise stimulation improves neuroplasticity in perceptual learning
    Anna Fertonani
    Cognitive Neuroscience Section, IRCCS Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
    J Neurosci 31:15416-23. 2011
    ..e., direct current stimulation (tDCS) and random noise stimulation (tRNS)] during the execution of a visual perceptual learning task.
  27. pmc Noise during rest enables the exploration of the brain's dynamic repertoire
    Anandamohan Ghosh
    Theoretical Neuroscience Group, Institut des Sciences du Mouvement, Marseille, France
    PLoS Comput Biol 4:e1000196. 2008
    ..We specifically demonstrate that noise and time delays via propagation along connecting fibres are essential for the emergence of the coherent ..
  28. pmc High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
    Shaoxia Chen
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U K
    Ultramicroscopy 135:24-35. 2013
    ..Because there is much more noise than signal at high resolution in the images, this creates the possibility of noise reinforcement in the 3D map, ..
  29. pmc Blue whales respond to anthropogenic noise
    Mariana L Melcón
    Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e32681. 2012
    Anthropogenic noise may significantly impact exposed marine mammals...
  30. pmc Musical training during early childhood enhances the neural encoding of speech in noise
    Dana L Strait
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, IL, USA
    Brain Lang 123:191-201. 2012
    For children, learning often occurs in the presence of background noise. As such, there is growing desire to improve a child's access to a target signal in noise...
  31. pmc Attractive "quiet" courtyards: a potential modifier of urban residents' responses to road traffic noise?
    Anita Gidlöf-Gunnarsson
    The Sahlgrenska Academy at the University of Gothenburg, Occupational and Environmental Medicine, Box 414, SE 40530 Gothenburg, Sweden
    Int J Environ Res Public Health 7:3359-75. 2010
    ..courtyards (degree of naturalness and utilization) on residents' noise responses...
  32. pmc Exploring the relationship between noise sensitivity, annoyance and health-related quality of life in a sample of adults exposed to environmental noise
    Daniel Shepherd
    Auckland University of Technology, Private Bag 92006, Auckland, 1142 New Zealand
    Int J Environ Res Public Health 7:3579-94. 2010
    The relationship between environmental noise and health is poorly understood but of fundamental importance to public health...
  33. pmc Training to improve hearing speech in noise: biological mechanisms
    Judy H Song
    Auditory Neuroscience Laboratory, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
    Cereb Cortex 22:1180-90. 2012
    We investigated training-related improvements in listening in noise and the biological mechanisms mediating these improvements...
  34. ncbi Changes in spontaneous neural activity immediately after an acoustic trauma: implications for neural correlates of tinnitus
    A J Noreña
    Department of Physiology and Biophysics, Neuroscience Research Group, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4
    Hear Res 183:137-53. 2003
    ..Moreover, rho was elevated in the Be-Ab2, Ab1-Ab2 and Ab2-Ab2 groups; this increase was significantly correlated to the changes in SFR. The results are discussed in the context of a neural correlate of tinnitus...
  35. ncbi Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex
    Paul G Mulquiney
    Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Department of Psychological Medicine, Commercial Rd, Melbourne, Victoria 3004, Australia
    Clin Neurophysiol 122:2384-9. 2011 determine if working memory (WM) performance is significantly improved after the delivery of transcranial random noise stimulation (tRNS) to the left dorsolateral prefrontal cortex (DLPFC), compared to an active comparator or sham.
  36. ncbi Development and validation of an automatic speech-in-noise screening test by telephone
    Cas Smits
    Department of Otolaryngology Audiology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Audiol 43:15-28. 2004
    To meet the need for an objective self-test for hearing screening. a new Dutch speech-in-noise test was developed. Digit triplets were used as speech material...
  37. pmc Estimates of the contribution of single neurons to perception depend on timescale and noise correlation
    Marlene R Cohen
    Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 29:6635-48. 2009
    ..information available to an animal, is limited by the sensitivity of single neurons in the population and by noise correlation between neurons...
  38. ncbi Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism
    A F Arnsten
    Section of Neurobiology, Yale Medical School, New Haven, Conn 06520 8001, USA
    Arch Gen Psychiatry 55:362-8. 1998
    ..Our study examined the effects of acute, mild stress exposure on higher cognitive function in monkeys and the role of dopaminergic mechanisms in the stress response...
  39. ncbi Noise pollution: non-auditory effects on health
    Stephen A Stansfeld
    Department of Psychiatry, Medical Sciences Building, Queen Mary, University of London, London, UK
    Br Med Bull 68:243-57. 2003
    b>Noise is a prominent feature of the environment including noise from transport, industry and neighbours. Exposure to transport noise disturbs sleep in the laboratory, but not generally in field studies where adaptation occurs...
  40. ncbi Motor learning is optimally tuned to the properties of motor noise
    Robert J van Beers
    Department of Physics of Man, Helmholtz Institute, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Neuron 63:406-17. 2009
    ..Crucial for this strategy is that motor noise arises partly centrally, in movement planning, and partly peripherally, in movement execution...
  41. ncbi Delayed production of free radicals following noise exposure
    Daisuke Yamashita
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
    Brain Res 1019:201-9. 2004
    Reactive oxygen and reactive nitrogen species (ROS, RNS) formed in the inner ear in response to high-intensity noise are thought to play an important role in noise-induced hearing loss (NIHL)...
  42. pmc Noise exposure and public health
    W Passchier-Vermeer
    TNO Prevention and Health, Leiden, The Netherlands
    Environ Health Perspect 108:123-31. 2000
    Exposure to noise constitutes a health risk...
  43. ncbi Cochlear implant speech recognition with speech maskers
    Ginger S Stickney
    University of California, Department of Otolaryngology Head and Neck Surgery, Irvine, California 92697 1275, USA
    J Acoust Soc Am 116:1081-91. 2004
    ..and cochlear-implant listeners with maskers consisting of either steady-state speech-spectrum-shaped noise or a competing sentence...
  44. ncbi Noise analysis in magnetic resonance electrical impedance tomography at 3 and 11 T field strengths
    Rosalind Sadleir
    Department of Biomedical Engineering, University of Florida, Gainesville, USA
    Physiol Meas 26:875-84. 2005
    ..This magnetic flux density is contaminated with noise, which ultimately limits the quality of reconstructed conductivity and current density images...
  45. pmc Context-dependent encoding in the auditory brainstem subserves enhanced speech-in-noise perception in musicians
    A Parbery-Clark
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, IL 60208, USA
    Neuropsychologia 49:3338-45. 2011
    Musical training strengthens speech perception in the presence of background noise. Given that the ability to make use of speech sound regularities, such as pitch, underlies perceptual acuity in challenging listening environments, we ..
  46. ncbi GIN (Gaps-In-Noise) test performance in subjects with confirmed central auditory nervous system involvement
    Frank E Musiek
    University of Connecticut, Storrs, Connecticut 06269 1085, USA
    Ear Hear 26:608-18. 2005
    The purpose of the present study was to investigate the value of a new gap detection procedure called Gaps-In-Noise (GIN) for assessment of temporal resolution in a clinical population.
  47. ncbi Combining directional microphone and single-channel noise reduction algorithms: a clinical evaluation in difficult listening conditions with cochlear implant users
    Adam A Hersbach
    Cochlear Ltd, 174 Victoria Parade, East Melbourne, Australia 3002
    Ear Hear 33:e13-23. 2012
    This study tested a combination of algorithms designed to improve cochlear implant performance in noise. A noise reduction (NR) algorithm, based on signal to noise ratio estimation was evaluated in combination with several directional ..
  48. ncbi Zebrafish responds differentially to a robotic fish of varying aspect ratio, tail beat frequency, noise, and color
    Nicole Abaid
    Department of Mechanical and Aerospace Engineering, Polytechnic Institute of New York University, Brooklyn, NY 11201, USA
    Behav Brain Res 233:545-53. 2012
    ..On the other hand, we find that varying the aspect ratio and coloration of the robot strongly influences fish preference...
  49. ncbi A new context-based approach to assess marine mammal behavioral responses to anthropogenic sounds
    W T Ellison
    Marine Acoustics Inc 809 Aquidneck Avenue, Middletown, RI 02840, USA
    Conserv Biol 26:21-8. 2012
    ..g., shipping). It has been demonstrated that increases in human activity and background noise can alter habitats of marine animals and potentially mask communications for species that rely on sound to mate, ..
  50. ncbi Speech-in-noise screening tests by internet, part 2: improving test sensitivity for noise-induced hearing loss
    Monique C J Leensen
    Clinical and Experimental Audiology, ENT Department, Academic Medical Centre AMC, Amsterdam, The Netherlands
    Int J Audiol 50:835-48. 2011
    An easily accessible screening test can be valuable in the prevention of noise-induced hearing loss (NIHL)...
  51. pmc Long-term exposure to road traffic noise and incident diabetes: a cohort study
    Mette Sørensen
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Environ Health Perspect 121:217-22. 2013
    Road traffic noise at normal urban levels can lead to stress and sleep disturbances. Both excess of stress hormones and reduction in sleep quality and duration may lead to higher risk for type 2 diabetes.
  52. pmc Perceptual learning reflects external noise filtering and internal noise reduction through channel reweighting
    B A Dosher
    Department of Cognitive Sciences, Institute of Mathematical Behavioral Sciences, and Center for Neurobiology of Learning and Memory, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 95:13988-93. 1998 a peripheral orientation discrimination task with systematically varying amounts of external (environmental) noise. The signal contrasts required to achieve threshold were reduced by a factor or two or more after training at all ..
  53. pmc Traumatic noise activates Rho-family GTPases through transient cellular energy depletion
    Fu Quan Chen
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 32:12421-30. 2012
    ..Here, we characterize the auditory pathology of adult male CBA/J mice exposed to traumatic noise (2-20 kHz; 106 dB; 2 h)...
  54. pmc Frequency-specific modulation of population-level frequency tuning in human auditory cortex
    Hidehiko Okamoto
    Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Malmedyweg 15, 48149 Muenster, Germany
    BMC Neurosci 10:1. 2009
    ..random) under auditory focused attention by means of magnetoencephalography (MEG)...
  55. pmc Wind turbine noise, annoyance and self-reported health and well-being in different living environments
    Eja Pedersen
    Occupational and Environmental Medicine, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Occup Environ Med 64:480-6. 2007
    To evaluate the prevalence of perception and annoyance due to wind turbine noise among people living near the turbines, and to study relations between noise and perception/annoyance, with focus on differences between living environments.
  56. pmc State-dependent representation of amplitude-modulated noise stimuli in rat auditory cortex
    Stephan L Marguet
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 31:6414-20. 2011
    ..A frozen amplitude-modulated white noise stimulus was repeatedly presented while recording neuronal populations and local field potentials (LFPs) in ..
  57. ncbi Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behavior in rats
    Fizza Naqvi
    Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan
    Pharmacol Rep 64:64-9. 2012
    b>Noise is defined as a displeasing and unwanted sound. It is one of the most encountered stressor to which mankind is exposed...
  58. ncbi When cognition kicks in: working memory and speech understanding in noise
    Jerker Ronnberg
    Linnaeus Centre HEAD, The Swedish Institute for Disability Research, Snekkersten, Denmark
    Noise Health 12:263-9. 2010
    ..load and cognitive load can be separately manipulated and dissociated in their effects on speech understanding in noise. The Ease of Language Understanding model assumes a theoretical position where perceptual task characteristics ..
  59. ncbi Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise
    Nadine Gaab
    Department of Psychology, Stanford University, Stanford, California, USA
    Hum Brain Mapp 28:703-20. 2007
    We compared two experimental designs aimed at minimizing the influence of scanner background noise (SBN) on functional MRI (fMRI) of auditory processes with one conventional fMRI design...
  60. pmc Noise trauma impairs neurogenesis in the rat hippocampus
    K S Kraus
    Center for Hearing and Deafness, 137 Cary Hall, University at Buffalo, Buffalo, NY 14214, USA
    Neuroscience 167:1216-26. 2010
    ..Based on earlier observations where exposure to high-intensity noise not only caused hearing loss but also impaired memory function, it is conceivably that noise exposure may suppress ..
  61. ncbi Laminar cortical dynamics of conscious speech perception: neural model of phonemic restoration using subsequent context in noise
    Stephen Grossberg
    Center for Adaptive Systems, Boston University, 677 Beacon Street, Boston, Massachusetts 02215, USA
    J Acoust Soc Am 130:440-60. 2011 generate conscious speech and language percepts? How does the brain restore information that is occluded by noise, or absent from an acoustic signal, by integrating contextual information over many milliseconds to disambiguate ..
  62. ncbi Increases in deep ocean ambient noise in the Northeast Pacific west of San Nicolas Island, California
    Mark A McDonald
    WhaleAcoustics, 11430 Rist Canyon Road, Bellvue, Colorado 80512, USA
    J Acoust Soc Am 120:711-8. 2006
    Recent measurement at a previously studied location illustrates the magnitude of increases in ocean ambient noise in the Northeast Pacific over the past four decades...
  63. pmc A detailed characterization of loud noise stress: Intensity analysis of hypothalamo-pituitary-adrenocortical axis and brain activation
    Andrew Burow
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Muenzinger Bldg, Rm D244, UCB 345, Boulder, CO 80309, USA
    Brain Res 1062:63-73. 2005
    ..the release of adrenocorticotropin hormone (ACTH) and corticosterone in response to the perceived threat of loud noise. This experiment involved placing rats in acoustic chambers overnight to avoid any handling and context changes ..
  64. ncbi A noisy spring: the impact of globally rising underwater sound levels on fish
    Hans Slabbekoorn
    Behavioural Biology, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
    Trends Ecol Evol 25:419-27. 2010
    ..Here we call attention to the urgent need to study the role of sound in the lives of fish and to develop a better understanding of the ecological impact of anthropogenic noise.
  65. ncbi Rapid formation of robust auditory memories: insights from noise
    Trevor R Agus
    Laboratoire Psychologie de la Perception, CNRS and Université Paris Descartes, Paris, France
    Neuron 66:610-8. 2010
    ..Unbeknownst to listeners, some noise samples reoccurred randomly throughout an experimental block...
  66. ncbi Acoustic communication in noise: regulation of call characteristics in a New World monkey
    Henrik Brumm
    Freie Universitat Berlin, Institut fur Biologie, Verhaltensbiologie, Haderslebener Strasse 9, 12163 Berlin, Germany
    J Exp Biol 207:443-8. 2004
    This study on common marmosets Callithrix jacchus is the first to examine noise-dependent mechanisms of vocal plasticity in a New World monkey...
  67. ncbi Anatomical and functional recovery of the goldfish (Carassius auratus) ear following noise exposure
    Michael E Smith
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    J Exp Biol 209:4193-202. 2006
    ..However, regenerative capabilities following noise exposure have not been explored in fish...
  68. ncbi Noise-induced stress response and hearing loss in goldfish (Carassius auratus)
    Michael E Smith
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    J Exp Biol 207:427-35. 2004 document the effects of such anthropogenic (human-generated) sounds on marine mammals, the effects of excess noise on fishes are poorly understood...
  69. pmc Annoyance from transportation noise: relationships with exposure metrics DNL and DENL and their confidence intervals
    H M Miedema
    TNO PG, Leiden, The Netherlands
    Environ Health Perspect 109:409-16. 2001
    We present a model of the distribution of noise annoyance with the mean varying as a function of the noise exposure. Day-night level (DNL) and day-evening-night level (DENL) were used as noise descriptors...
  70. ncbi Ecology: Birds sing at a higher pitch in urban noise
    Hans Slabbekoorn
    Behavioural Biology, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, The Netherlands
    Nature 424:267. 2003
  71. pmc Inherent noise can facilitate coherence in collective swarm motion
    Christian A Yates
    Centre for Mathematical Biology, University of Oxford, 24 29 St Giles, Oxford OX1 3LB, United Kingdom
    Proc Natl Acad Sci U S A 106:5464-9. 2009
    ..We give a quantitative description of how locusts use noise to maintain swarm alignment...
  72. ncbi Noise pollution changes avian communities and species interactions
    Clinton D Francis
    Department of Ecology and Evolutionary Biology, University of Colorado at Boulder, 334 UCB, Boulder, CO 80309, USA
    Curr Biol 19:1415-9. 2009
    ..We evaluated conservation concerns that noise limits bird distributions and reduces nesting success via a natural experiment to isolate the effects of noise ..
  73. ncbi Neuropathology and pressure in the pig brain resulting from low-impulse noise exposure
    Annette Säljö
    Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Sahlgren Academy, University of Gothenburg, Gothenburg, Sweden
    J Neurotrauma 25:1397-406. 2008
    ..Moreover, part of this pressure could have been derived from the air outside the head. The results gave little support to significant transmission of pressure within the body...
  74. ncbi Spontaneous brain rhythms predict sleep stability in the face of noise
    Thien Thanh Dang-Vu
    Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 20:R626-7. 2010
    ..who generated more sleep spindles during a quiet night of sleep went on to exhibit higher tolerance for noise during a subsequent, noisy night of sleep...
  75. ncbi Noise exposure levels from personal stereo use
    Warwick Williams
    National Acoustic Laboratories, 126 Greville Street, Chatswood, NSW, 2067, Australia
    Int J Audiol 44:231-6. 2005
    Hearing healthcare professionals often express concern about the possible increased risk of noise injury, and potential for subsequent hearing loss that may result from the rise in the use of personal stereo players (PSP) in the ..
  76. ncbi Effects of directional microphone and adaptive multichannel noise reduction algorithm on cochlear implant performance
    King Chung
    Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Acoust Soc Am 120:2216-27. 2006
    ..CI) users have enjoyed good speech recognition in quiet, they still have difficulties understanding speech in noise. We conducted three experiments to determine whether a directional microphone and an adaptive multichannel noise ..
  77. ncbi Recognition of speech in noise with new hearing instrument compression release settings requires explicit cognitive storage and processing capacity
    Catharina Foo
    Department of Behavioural Sciences and Learning, Linkoping University, Sweden
    J Am Acad Audiol 18:618-31. 2007
    ..have investigated the predictive value of various cognitive tests in relation to aided speech recognition in noise using compression release settings that have been experienced for a certain period...
  78. pmc The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats
    Lukas Ruttiger
    Department of Otolaryngology, Hearing Research Centre Tübingen THRC, Molecular Physiology of Hearing, University of Tubingen, Tubingen, Germany
    PLoS ONE 8:e57247. 2013
    ..We compared equally noise exposed rats separated into groups with and without tinnitus for differences in brain responsiveness relative to ..
  79. ncbi Basic fibroblast growth factor protects auditory neurons and hair cells from glutamate neurotoxicity and noise exposure
    Suo Qiang Zhai
    Institute of Otorhinolaryngology, General Hospital of PLA, Beijing, People s Republic of China
    Acta Otolaryngol 124:124-9. 2004
    ..To determine the protective effects of basic fibroblast growth factor (bFGF) on cochlear neurons and hair cells in vitro and in vivo...
  80. ncbi Environmental noise retards auditory cortical development
    Edward F Chang
    W M Keck Center for Integrative Neuroscience, University of California, San Francisco, CA, USA
    Science 300:498-502. 2003
    ..Here we show that rearing infant rat pups in continuous, moderate-level noise delayed the emergence of adultlike topographic representational order and the refinement of response selectivity ..
  81. pmc A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics
    Muhammad S A Zilany
    Department of Biomedical Engineering, University of Rochester, NY 14642, USA
    J Acoust Soc Am 126:2390-412. 2009
  82. ncbi The digits-in-noise test: assessing auditory speech recognition abilities in noise
    Cas Smits
    Department of Otolaryngology Audiology and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Acoust Soc Am 133:1693-706. 2013
    A speech-in-noise test which uses digit triplets in steady-state speech noise was developed. The test measures primarily the auditory, or bottom-up, speech recognition abilities in noise...
  83. pmc Time course of tinnitus development following noise exposure in mice
    Jeremy Turner
    Department of Surgery Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Neurosci Res 90:1480-8. 2012
    ..Six-month-old mice on a mixed C57Bl6 × 129 background were anesthetized with isoflurane and exposed to unilateral noise (n = 15), or sham exposure for controls (n = 8), for 1 hr (16-kHz octave band signal, 116-dB SPL)...
  84. ncbi Low frequency noise and annoyance
    H G Leventhall
    Noise and Vibration Consultant, Ashtead, Surrey, UK
    Noise Health 6:59-72. 2004
    Low frequency noise, the frequency range from about 10 Hz to 200 Hz, has been recognised as a special environmental noise problem, particularly to sensitive people in their homes...
  85. pmc Quiet areas and the need for quietness in Amsterdam
    Hester Booi
    Department for Research and Statistics O S, Municipality of Amsterdam, PO Box 2200, 1000 CE Amsterdam, The Netherlands Email
    Int J Environ Res Public Health 9:1030-50. 2012 a model showing the influence of demographic and socio-economic issues, health status, sensitiveness to noise, daily activities and the noisiness in and around home. Most important of these factors is sensitivity to noise...
  86. ncbi Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma
    A J Noreña
    Universite de Provence, CNRS UMR 6149, Marseille, France
    Neuroscience 166:1194-209. 2010 the same animals under each condition allowed direct comparison of the effects of salicylate and trauma (noise trauma was carried out several days after full recovery from salicylate administration)...
  87. ncbi Reduced startle reflex and aversive noise perception in patients with orbitofrontal cortex lesions
    Alessandro Angrilli
    Department of General Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy
    Neuropsychologia 46:1179-84. 2008
    ..The orbitofrontal cortex, together with the amygdala, is confirmed to represent the main center organizing both primary and secondary learned aspects of emotions...
  88. pmc Adaptive avoidance of reef noise
    Stephen D Simpson
    School of Biological Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e16625. 2011
    ..Some marine species are dependent on reefs for adult survival and reproduction, and are known to use reef noise to guide orientation towards suitable habitat...
  89. ncbi Speech reception thresholds in noise and self-reported hearing disability in a general adult population
    Cas Smits
    Department of Otolaryngology Audiology, EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Ear Hear 27:538-49. 2006
    The principal objective of this study was to describe speech reception thresholds in noise (SRTTn, i.e., the signal-to-noise ratio corresponding to 50% intelligibility) and self-reported hearing disability in a general adult population...
  90. ncbi The effects of human-generated sound on fish
    Arthur N Popper
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Integr Zool 4:43-52. 2009
  91. pmc The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo NY 14214, USA
    Hear Res 236:11-21. 2008
    Previous studies have shown that exposure to intense noise causes outer hair cells (OHCs) to die, primarily through the process of apoptotic degeneration...
  92. ncbi Reexamining the evidence for a pitch-sensitive region: a human fMRI study using iterated ripple noise
    Daphne Barker
    MRC Institute of Hearing Research, Nottingham, NG7 2RD, UK
    Cereb Cortex 22:745-53. 2012
    ..a region of auditory cortex, lateral Heschl's gyrus (HG), that shows a greater response to iterated ripple noise (IRN) than to a Gaussian noise control...
  93. ncbi The effect of spatial separation on informational and energetic masking of speech
    Tanya L Arbogast
    Department of Communication Disorders and The Hearing Research Center, Boston University, Massachusetts 02215, USA
    J Acoust Soc Am 112:2086-98. 2002
    ..listeners performed a closed-set speech identification task in the presence of a masker at various signal-to-noise ratios. Stimuli were presented in a quiet sound field...
  94. ncbi Characterizing observers using external noise and observer models: assessing internal representations with external noise
    Zhong lin Lu
    Laboratory of Brain Processes LOBES, Dana and David Dornsife Cognitive Neuroscience Imaging Center, Department of Psychology, University of Southern California, USA
    Psychol Rev 115:44-82. 2008
    External noise methods and observer models have been widely used to characterize the intrinsic perceptual limitations of human observers and changes of the perceptual limitations associated with cognitive, developmental, and disease ..
  95. pmc Noise pollution filters bird communities based on vocal frequency
    Clinton D Francis
    Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado, United States of America
    PLoS ONE 6:e27052. 2011
    Human-generated noise pollution now permeates natural habitats worldwide, presenting evolutionarily novel acoustic conditions unprecedented to most landscapes...
  96. ncbi Early continuous white noise exposure alters auditory spatial sensitivity and expression of GAD65 and GABAA receptor subunits in rat auditory cortex
    Jinghong Xu
    School of Life Science, Institute of Cognitive Neuroscience, Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, East China Normal University, Shanghai, China
    Cereb Cortex 20:804-12. 2010
    ..Here, we show how early continuous noise rearing influences spatial sensitivity in the rat primary auditory cortex (A1) and its underlying mechanisms...
  97. ncbi Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats
    Hong Kim
    Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi dong, Dongdaemoon gu, Seoul 130 701, South Korea
    Brain Dev 28:109-14. 2006
    ..In the present study, the influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats was investigated...
  98. pmc Denoising based on spatial filtering
    Alain de Cheveigné
    Laboratoire de Psychologie de la Perception, UMR 8158, CNRS and Université Paris Descartes, France
    J Neurosci Methods 171:331-9. 2008
    ..In experiments that measure stimulus-evoked activity, typically about 80% of noise power is removed with minimal distortion of the evoked response...
  99. ncbi Are hearing sensitivities of freshwater fish adapted to the ambient noise in their habitats?
    Sonja Amoser
    University of Vienna, Department of Neurobiology and Behavior, Althanstrasse 14, 1090 Vienna, Austria
    J Exp Biol 208:3533-42. 2005
    ..To test this hypothesis, noise levels and frequency spectra of four different freshwater habitats near Vienna, Austria (Danube River, Triesting ..
  100. ncbi Comprehension of familiar and unfamiliar native accents under adverse listening conditions
    Patti Adank
    Donders Institute for Brain, Cognition, and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Exp Psychol Hum Percept Perform 35:520-9. 2009
    ..Two sentence verification experiments were conducted in which listeners heard sentences at various signal-to-noise ratios...
  101. ncbi Impact of fMRI acoustic noise on the functional anatomy of visual mental imagery
    A Mazard
    CNRS UMR 6905, CEA, Universite de Caen, Paris, France
    J Cogn Neurosci 14:172-86. 2002
    One drawback of functional magnetic resonance imaging (fMRI) is that the subject must endure intense noise during testing. We examined the possible role of such noise on the activation of early visual cortex during visual mental imagery...

Research Grants81

  1. Evaluation of a Hearing Conservation Program for Farm Youth: A 15-Year Follow-up
    BARBARA L MARLENGA; Fiscal Year: 2010
    ..Agriculture is one of the industries identified to have the highest exposure to dangerous levels of noise. Youth who work in agricultural production are exposed to these dangerous noise levels and several studies have ..
  2. Optimized Conditioned Processing for Cochlear Implants
    Jay T Rubinstein; Fiscal Year: 2010
    ..In a noisy background, however, particularly if that noise is competing speech, speech perception is dramatically impaired...
  3. Effects of Acoustic Trauma on Age-Related Hearing Loss
    Dianne Durham; Fiscal Year: 2002
    ..Many factors contribute to this age-related hearing loss, including exposure to environmental noise, certain diseases, drug-induced ototoxicity, as well as inheritance of specific genes...
  4. Prevention of Noise-Induced Hearing Loss in Children and Adolescents
    William Martin; Fiscal Year: 2005
    ..setting, a diverse group of basic and applied science researchers with expertise related to the prevention of noise-induced hearing loss (NIHL) in children and adolescents...
  5. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    b>Noise levels in neonatal intensive care units (NICUs) may have serious adverse effects on high risk infants by increasing apneic, bradycardic, or desaturation episodes; sleep disturbances; mechanical ventilation; hospital stay; poor ..
  6. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  7. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  8. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  9. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..Broadband approaches, have shown significantly tighter normal ranges, lower noise, and better reproducibility in vivo...
  10. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..with the dEEG data is provided by high performance compute clusters: (1) to separate brain signals from noise (e.g., movement, cardiac, equipment artifacts) and (2) to recognize pathological brain states (e.g,...
  11. Cell signaling as a leukemia biomarker
    ..sys- tem that works at the level of single cells, therefore, the specificity of detection and signal to noise ratio can be very high...
  12. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..The four aims will: 1) Generate high signal- to-noise multicolor fluorescence images of neuropeptide projections in the macaque limbic system (hypothalamus- a subset of ..
  13. Mechanisms of Cochlear Oxidative Stress Injury and Strategies to Protect Hearing
    Michael J Brenner; Fiscal Year: 2013
    ..of oxidative stress based on prior studies showing that reactive oxygen species contribute to drug-induced and noise-induced hearing loss and that dampening these reactive oxygen species may confer otoprotection...
    Dennis G Drescher; Fiscal Year: 2013 an issue addressed in the present proposal for the neuropeptide PACAP, important in excitotoxicity and noise-induced deafness...
  15. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..Our recent work in a mouse model of noise and aging shows that moderate exposures, which initially appear reversible and cause no acute or chronic hair cell ..
  16. Visualization of ototoxic mitochondrial dysfunction in mammalian hair cells
    Shelley A Batts; Fiscal Year: 2012 often caused by the sudden or gradual death of the cochlear hair cells, which are vulnerable to damage from noise, age, infection and toxic drugs...
  17. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..Studies will be performed using in vitro cultures of inner ear sensory epithelia, and in vivo studies of noise damage to the cochlea...
  18. Proteome Bead-Display for Discovery of Tumor Antigens
    Mark Lim; Fiscal Year: 2013
    ..and validation of a new TAA for CRC on the Bead-GPSTM platform by using candidate pre-selection with ultra-low noise gene expression profiling;v) demonstration of a MALDI-MSI bead barcoding system capable of generating tens of ..
    Robert Fettiplace; Fiscal Year: 2013
    ..mechanotransducer channels is probably common to all hair cells and may be the site of irreversible damage during noise exposure, poisoning with ototoxic agents or aging...
  20. Genetics of Age-Related Hearing Loss
    Kenneth R Johnson; Fiscal Year: 2013
    ..studies in humans are difficult because of the late onset of the condition and because non-genetic factors such as noise trauma, disease, and ototoxic drugs confound interpretations...
  21. Detection of Prostate Cancer Genomic Signatures in Blood
    Amin I Kassis; Fiscal Year: 2010
    ..signal) that are not expressed or minimally expressed in the nonphagocytic cells (patient-specific noise)...
    Raphael Kopan; Fiscal Year: 2010
    ..Split-DamID has several key advantages: much improved signal to noise ratio compared with ChIP or DamID;adenine methylation indelibly marks DNA bound by the fusion protein, allowing ..
  23. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009 providing funding to support audiometry exams and questions relating to hearing loss/hearing aid use, tinnitus, noise exposure, and other factors that affect hearing thresholds...
  24. Enforcing Underage Drinking Laws (EUDL)
    Christopher Spera; Fiscal Year: 2009
    ..impacts, as well -- the most common problems are underage drinking, crime, vandalism, public disturbances, noise, fights, physical attacks, traffic crashes, and drunk driving...
    Donald M Caspary; Fiscal Year: 2013
    ..subjects with similar thresholds show age-related decrements in temporal processing and speech understanding in noise. This suggests that seniors have difficulty attending to and comprehending speech in a public setting leading to a ..
  26. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..Damage to the auditory periphery (e.g. as a consequence of loud-noise exposure or aging), which does not even have to manifest itself in a measurable hearing loss, causes some central ..
  27. Identifying the Atoh1 targetome in hair cells with deep sequencing
    Andrew K Groves; Fiscal Year: 2013
    ..In addition to genetic factors, damage from noise exposure or from certain kinds of antibiotics and chemotherapy drugs can kill hair cells...
  28. TSQ Vantage Bundle with Acquity UltraPerformance LC
    Nicolaas E Deutz; Fiscal Year: 2010
    ..year, 1 full-time technician/operator for two years, and minor modifications (solvent vent line, pump noise abatement) to an existing LC-MS laboratory...
  29. Volumetric Perfusion MRI of Liver Tumors to Detect Early Response to Chemotherapy
    Scott B Reeder; Fiscal Year: 2010
    ..coverage, 2) high spatial resolution and 3) high temporal resolution, while maintaining 4) good signal to noise ratio (SNR), and 5) fidelity of Gadolinium contrast uptake curves in tissue...
  30. Regeneration of stereocilia of cochlear hair cells
    David Z Z He; Fiscal Year: 2010
    ..apparatus, the stereocilium bundle on the surface of the hair cell, as a result of aging or exposure to noise and ototoxic drugs is the major cause of noncongenital hearing and balance deficits...
  31. Light-Alarming Personal Noise Dosimeter System
    ALEXANDER MILOVANOV; Fiscal Year: 2013
    PROJECT SUMMARY/ABSTRACT Occupational noise is a widespread risk factor, linking it strongly to critical health hazards, such as hearing loss, psychiatric disorders, increased blood pressure, and harmful biochemical, immune system, and ..
  32. Novel Approaches for Prevention and Treatment of Noise Induced Hearing loss
    Debashree Mukherjea; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Noise induced hearing loss (NIHL) is a significant problem in the United States, affecting ~15 percent of individuals from all age groups...
  33. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..While wearers of bilateral implants show improved sound localization and speech reception in noise, their ability to process interaural time differences (ITD) is still far from normal, resulting in smaller ..
  34. Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRI
    Scott B Reeder; Fiscal Year: 2013
    ..Other important confounding factors must also be addressed. These include: T1 relaxation, image noise, the multiple NMR spectral peaks of fat, and eddy currents...
  35. Metabolic and Energetic Consequences of Fatherhood
    Wendy Saltzman; Fiscal Year: 2013
    ..Half of the mice in each group will be exposed to a chronic, intermittent noise stressor, and the other half will be maintained under standard laboratory conditions...
  36. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..experience inappropriate shocks within three years of implant in response to a non-lethal arrhythmia or electrical noise within the device...
  37. Analysis of Hair Cell Regeneration in Zebrafish
    DESCRIPTION (provided by applicant): A prominent cause of deafness is loss of hair cells due to age, noise or antibiotic treatments...
    David P Corey; Fiscal Year: 2013
    ..or mutating Ca2+-binding residues allows cadherins to unfold at lower force, making them more susceptible to loud noise. We will also use molecular dynamics to explore the predicted heteromeric binding interface by asking what forces ..
  39. Molecular mechanisms of auditory nAChR synapse assembly
    Michele H Jacob; Fiscal Year: 2013
    Abstract: Sensorineural hearing loss affects 30 million Americans. Aging, noise-overexposure, infection and ototoxic antibiotics all lead to sensory hair cell degeneration and permanent hearing loss...
  40. Low-cost handheld medical device for neuroaxial anesthesia guidance in the obese
    FRANK WILLIAM MAULDIN; Fiscal Year: 2012
    ..A functional handheld ultrasound prototype with real-time image display and electronic signal-to-noise ratio (SNR) from bone >15 dB at image depths of 10 cm will be demonstrated...
  41. Mechanisms of Sensory Regeneration
    Mark Warchol; Fiscal Year: 2013
    ..Hair cells can be injured or lost as a result of noise exposure, ototoxic medications, inner ear infections, or as part of normal aging...
  42. Occupational exposure to manganese and noise potentiate hearing loss
    Richard J Salvi; Fiscal Year: 2013
    ..welding fumes induce hearing impairment in rabbits and that the hearing deficits are exacerbated by exposure to noise. Since Mn has been reported to accumulate in the inner ear (cochlea) following acute treatment, we hypothesize ..
  43. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..blood supply can cause serious hearing disorders including sudden sensorineural hearing loss, presbyacusis, noise-induced hearing loss, tinnitus, and certain vestibulopathies...
  44. Auditory Cortex Plasticity and Tinnitus
    Brian Allman; Fiscal Year: 2012
    ..Tinnitus, in its chronic form, is most often associated with noise-induced hearing loss...
    Jochen Schacht; Fiscal Year: 2013
    ..ear that may also be relevant for understanding other cochlear pathologies such as cisplatin-induced hearing loss, noise trauma and age-related hearing impairment...
  46. Aging Auditory System: Presbycusis and Its Neural Bases
    Robert D Frisina; Fiscal Year: 2013
    ..speech, and a serious reduction in sound processing capacity essential for understanding speech in background noise. Notably, we have demonstrated that temporal and spatial processing problems linked to speech perception-in-noise ..
  47. Regulation of stem cell fate by protein degradation
    Andre Catic; Fiscal Year: 2013
    ..Transcriptional noise is reduced on multiple levels in stem cells: transcriptional repressors, epigenetic factors, and RNA inhibition ..
  48. Transgenic Mitomice Models for Treatment of Blinding Diseases
    John Guy; Fiscal Year: 2013
    ..cell (RGC) demise and optic neuropathy with pattern electroretinogram (PERG) amplitudes declining steadily to noise levels one year after birth...
  49. Intercellular trafficking of labeled aminoglycosides in living hair cells
    Dale Warren Hailey; Fiscal Year: 2013
    ..Many environmental and genetic factors contribute to hair cell death in the human population, including noise, age, and ototoxic drug exposure...
  50. PCBs, PBDEs, Hearing Loss & Attention/Impulsivity: Mechanistic Studies in Animals
    Susan L Schantz; Fiscal Year: 2010
    ..Because the outer hair cells are believed to protect against noise induced hearing loss, studies will also be conducted to determine if early PCB exposure increases susceptibility ..
    JEROME Z LIANG; Fiscal Year: 2013
    ..algorithm will consider not only the X-ray quanta statistics and energy spectrum, but also the system background noise because this noise plays a noticeable role at low mAs level...
  52. Expression-Based Multi-Gene Signatures for CRC Recurrence and Chemoselection
    Christopher Sears; Fiscal Year: 2012
    ..CRC tumor samples with known clinical outcome data going back 5 years, ii) Measurement and analysis of low-noise gene expression microarray data, iii) Generation of priority gene list by Meta-Analysis, iv) Validation of the ..
  53. Sound Source Segregation
    Mark A Bee; Fiscal Year: 2013 the auditory system's ability to separate sounds of interest from other overlapping sounds and background noise. Hearing aids and cochlear implants often provide their users little benefit when it comes to segregating multiple ..
  54. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..The pixel dwell time is increased. It allows lower excitation laser power and higher sensitivity. The signal-to-noise ratio would be higher than other full-field OCT imaging without confocal architecture...
  55. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..The pixel dwell time is increased. It allows lower excitation laser power and higher sensitivity. The signal-to-noise ratio would be higher than other full-field OCT imaging without confocal architecture...
  56. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..have been limited due to difficulty in production, short half-life, metabolic instability and moderate signal-to-noise ratios...
  57. Telehealth Tinnitus Intervention for Patients with TBI
    JAMES A contact HENRY; Fiscal Year: 2011
    ..This increase is due largely because of exposure to high levels of noise in the military, but also because tinnitus often is associated with traumatic brain injury and post-traumatic ..
  58. Screening Lung Cancer by Ultra Low-Dose Computed Tomography
    JEROME Z LIANG; Fiscal Year: 2013
    ..We have been exploring adaptive noise-treatment strategies to reconstruct similar image quality at significantly low mAs level for ultra low-dose CT ..
  59. Stage-Specific Inhibitors of Orthopoxviruses
    John H Connor; Fiscal Year: 2012
    ..This assay has a signal-to-noise ratio of greater than 300:1 and allows kinetic as well as endpoint testing of replication...
  60. Regulation of outer hair cell electromotility and noise-induced hearing loss
    Gregory I Frolenkov; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Excessively loud sounds and noise are among the leading causes of deafness and hearing impairment in the US...
  61. Intrinsic plasticity and information storage in cerebellar Purkinje cells
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2012
    ..rate of the target DCN neurons, but lowers the impact of PF synapses onto Purkinje cells by reducing the signal-to-noise ratio. Here, we propose four specific aims to further characterize Purkinje cell intrinsic plasticity...
  62. Gene Expression in Rat Cochlea Following Loss of Hair Cells
    Erin Bailey; Fiscal Year: 2013
    ..Hair cells also provide survival-promoting neurotrophic factors for the SGNs. Genetic disorders, noise trauma, aging, and ototoxic drugs may all cause death of the hair cells...
  63. Non-linear Characterization of the Stretch Reflex Arc and its Neuromodulation
    AMAN BEHAL; Fiscal Year: 2011
    ..Broadly, experiments for modeling SRA components will involve bandlimited white noise current injection in current clamp mode into patch-clamped cells with concurrent recording of action potentials (..
  64. Image-based modeling of nonlinear and anisotropic intervertebral disc mechanics
    Edward J Vresilovic; Fiscal Year: 2010
    ..the pulse sequence and adjust the sequence parameters as required to optimize resolution, contrast, and signal-to-noise ratio...
  65. Determining how aminoglycoside-induced hair cell death is blocked
    Dale Warren Hailey; Fiscal Year: 2010
    ..Age-related and noise-induced hearing loss is largely attributable to death of hair cells...
  66. Accelerating Cancer Research with Single Cell Arrays
    Heinz Ulrich Weier; Fiscal Year: 2009
    ..Thus, a second objective of the proposed research is the development of techniques to increase signal-to-noise ratios through RNA digestion or blocking. The two Specific Aims of the present application are 1...
  67. Genetics of Parkinsonism in a Special Population of Untreated Schizophrenia
    Gabriel Alejandro De Erausquin; Fiscal Year: 2013
    ..Studyinguntreated patients prevents the noise introduced into such phenotypic manifestationsby the effects of antipsychotic drugs, and therefore will permit ..
    Robert Helfert; Fiscal Year: 1999
    ..Disproportionately poor speech discrimination, particularly in the presence of background noise is one characteristic of age-related hearing loss and is thought to reflect, in part, changes in the central ..
  69. Evaluation of Approaches to Auditory Rehabilitation for Mild TBI
    Gabrielle Saunders; Fiscal Year: 2009
    ..FM systems substantially improve the signal-to-noise ratio of speech in noisy and reverberant environments, theoretically making more resources available for higher ..
  70. Telephone screening test for hearing using three-digit sequences in noise.
    Charles Watson; Fiscal Year: 2009
    This project will develop a speech-recognition test in noise (SRTn) for use as a screening test for hearing disability, suitable for delivery over the telephone...
    Jianxin Bao; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard...
  72. Hearing Therapies for the Future
    Gabrielle Saunders; Fiscal Year: 2007
    ..The conference objective is to expand understanding and facilitate effective treatment of noise induced hearing loss (NIHL)...
  73. Preventing NIHL by enhancing glutathione pathways
    Richard Kopke; Fiscal Year: 2002
    The primary objective of these studies is to test and develop pharmacologic agents to protect against noise-induced hearing loss (NIHL). The long-term objective is to develop agents for oral administration in clinical populations...
    Glen Miller; Fiscal Year: 1990
    ..The majority of vocational educators do not recognize the risk which noise poses to their students or themselves...
  75. Tribal Community-Based Prevention of Noise-Induced Hearing Loss and Tinnitus
    William Martin; Fiscal Year: 2007
    ..b>Noise-induced hearing loss (NIHL) and related tinnitus are significant health risks for the general population and ..
    Peter Rabinowitz; Fiscal Year: 2000
    b>Noise-induced hearing loss is one of the most common occupational diseases. Thirty million US workers are exposed to potentially hazardous workplace noise...
  77. An Innovative Hearing Loss Prevention Approach For Infant Incubator
    Xun Yu; Fiscal Year: 2011
    ..However, excessive high levels of noise inside an infant incubator have been found to result in numerous adverse health effects especially hearing ..
    Kanae Nishi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Speech perception in adverse listening environments (e.g., noise) is more difficult than in quiet even for individuals with normal hearing...
  79. Potentiation--noise induced hearing loss--acrylonitrile
    Laurence Fechter; Fiscal Year: 2003
    Oxidative stress is recognized to play an important role in cochlear injury associated with noise exposure as well as ototoxicant exposure...
  80. Medial olivocochlear protection from environmental noise exposure
    AMANDA LAUER; Fiscal Year: 2009
    ..olivocochlear (OC) efferent feedback mechanisms may be a primary determinant of individual susceptibility to noise-induced hearing loss accumulated over a lifetime...
  81. Prevention of temporary hearing loss with AuraQuell
    PETER BOXER; Fiscal Year: 2009
    ..Of the 28 million Americans who have significant hearing loss, about one-third can be attributed, in part, to noise exposure...