Summary: The variety of all native living organisms and their various forms and interrelationships.

Top Publications

  1. pmc Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 75:7537-41. 2009
  2. pmc A core gut microbiome in obese and lean twins
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 457:480-4. 2009
  3. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
  4. pmc Microbial diversity in the deep sea and the underexplored "rare biosphere"
    Mitchell L Sogin
    Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
    Proc Natl Acad Sci U S A 103:12115-20. 2006
  5. pmc MEGAN analysis of metagenomic data
    Daniel H Huson
    Center for Bioinformatics, Tubingen University, Sand 14, 72076 Tubingen, Germany
    Genome Res 17:377-86. 2007
  6. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
  7. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
  8. ncbi Host-bacterial mutualism in the human intestine
    Fredrik Backhed
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 307:1915-20. 2005
  9. pmc Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    Carlotta De Filippo
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Firenze, Italy
    Proc Natl Acad Sci U S A 107:14691-6. 2010
  10. pmc Ironing out the wrinkles in the rare biosphere through improved OTU clustering
    Susan M Huse
    Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
    Environ Microbiol 12:1889-98. 2010

Detail Information

Publications351 found, 100 shown here

  1. pmc Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Appl Environ Microbiol 75:7537-41. 2009
    ..This analysis of more than 222,000 sequences was completed in less than 2 h with a laptop computer...
  2. pmc A core gut microbiome in obese and lean twins
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 457:480-4. 2009
  3. pmc Diversity of the human intestinal microbial flora
    Paul B Eckburg
    Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Room S 169, 300 Pasteur Drive, Stanford CA 94305 5107, USA
    Science 308:1635-8. 2005
    ..We discovered significant intersubject variability and differences between stool and mucosa community composition. Characterization of this immensely diverse ecosystem is the first step in elucidating its role in health and disease...
  4. pmc Microbial diversity in the deep sea and the underexplored "rare biosphere"
    Mitchell L Sogin
    Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
    Proc Natl Acad Sci U S A 103:12115-20. 2006
    ..Members of the rare biosphere are highly divergent from each other and, at different times in earth's history, may have had a profound impact on shaping planetary processes...
  5. pmc MEGAN analysis of metagenomic data
    Daniel H Huson
    Center for Bioinformatics, Tubingen University, Sand 14, 72076 Tubingen, Germany
    Genome Res 17:377-86. 2007
    ..Also, simulations that evaluate the performance of the approach for different read lengths are presented...
  6. pmc Bacterial community variation in human body habitats across space and time
    Elizabeth K Costello
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
    Science 326:1694-7. 2009
    ..These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease...
  7. pmc Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e27310. 2011
  8. ncbi Host-bacterial mutualism in the human intestine
    Fredrik Backhed
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 307:1915-20. 2005
    ..We are also starting to understand how certain keystone members of the microbiota operate to maintain the stability and functional adaptability of this microbial organ...
  9. pmc Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa
    Carlotta De Filippo
    Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Firenze, Italy
    Proc Natl Acad Sci U S A 107:14691-6. 2010
  10. pmc Ironing out the wrinkles in the rare biosphere through improved OTU clustering
    Susan M Huse
    Josephine Bay Paul Center, Marine Biological Laboratory at Woods Hole, 7 MBL Street, Woods Hole, MA 02543, USA
    Environ Microbiol 12:1889-98. 2010
    ..This new clustering method can reduce the OTU richness in environmental samples by as much as 30-60% but does not reduce the fraction of OTUs in long-tailed rank abundance curves that defines the rare biosphere...
  11. ncbi Wrinkles in the rare biosphere: pyrosequencing errors can lead to artificial inflation of diversity estimates
    Victor Kunin
    Microbial Ecology Program, DOE Joint Genome Institute, Walnut Creek, CA 94598, USA
    Environ Microbiol 12:118-23. 2010
    ..We suggest that stringent quality-based trimming of 16S pyrotags and clustering thresholds no greater than 97% identity should be used to avoid overestimates of the rare biosphere...
  12. pmc The human microbiome project
    Peter J Turnbaugh
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 449:804-10. 2007
    ..A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease...
  13. pmc Pyrosequencing-based assessment of soil pH as a predictor of soil bacterial community structure at the continental scale
    Christian L Lauber
    Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, 80309, USA
    Appl Environ Microbiol 75:5111-20. 2009
  14. ncbi Extinction risk from climate change
    Chris D Thomas
    Centre for Biodiversity and Conservation, School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Nature 427:145-8. 2004
    ..These estimates show the importance of rapid implementation of technologies to decrease greenhouse gas emissions and strategies for carbon sequestration...
  15. ncbi Biodiversity loss and its impact on humanity
    Bradley J Cardinale
    School of Natural Resources and Environment, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 486:59-67. 2012
    ..This observation led to the question of how such loss of biological diversity will alter the functioning of ecosystems and their ability to provide society with the goods and services needed to prosper...
  16. ncbi Status and trends of amphibian declines and extinctions worldwide
    Simon N Stuart
    IUCN Species Survival Commission Conservation International Center for Applied Biodiversity Science Biodiversity Assessment Unit, 1919 M Street N W, Washington, DC 20036, USA
    Science 306:1783-6. 2004
    ..The lack of conservation remedies for these poorly understood declines means that hundreds of amphibian species now face extinction...
  17. ncbi Cryptic species as a window on diversity and conservation
    David Bickford
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Republic of Singapore
    Trends Ecol Evol 22:148-55. 2007
    ..The discovery of cryptic species is likely to be non-random with regard to taxon and biome and, hence, could have profound implications for evolutionary theory, biogeography and conservation planning...
  18. ncbi Picante: R tools for integrating phylogenies and ecology
    Steven W Kembel
    Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR, USA
    Bioinformatics 26:1463-4. 2010
  19. ncbi Ecological and evolutionary forces shaping microbial diversity in the human intestine
    Ruth E Ley
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell 124:837-48. 2006
    ..The ecological rules that govern the shape of microbial diversity in the gut apply to mutualists and pathogens alike...
  20. pmc Topographical and temporal diversity of the human skin microbiome
    Elizabeth A Grice
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Science 324:1190-2. 2009
    ..This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin...
  21. ncbi Impacts of biodiversity on the emergence and transmission of infectious diseases
    Felicia Keesing
    Department of Biology, Bard College, Annandale, New York 12504, USA
    Nature 468:647-52. 2010
    Current unprecedented declines in biodiversity reduce the ability of ecological communities to provide many fundamental ecosystem services...
  22. ncbi Global biodiversity: indicators of recent declines
    Stuart H M Butchart
    United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK
    Science 328:1164-8. 2010
    ..committed, through the Convention on Biological Diversity, to achieve a significant reduction in the rate of biodiversity loss by 2010. We compiled 31 indicators to report on progress toward this target...
  23. ncbi Primary forests are irreplaceable for sustaining tropical biodiversity
    Luke Gibson
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
    Nature 478:378-81. 2011
    Human-driven land-use changes increasingly threaten biodiversity, particularly in tropical forests where both species diversity and human pressures on natural environments are high...
  24. pmc The diversity and biogeography of soil bacterial communities
    Noah Fierer
    Department of Biology and Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 103:626-31. 2006
    ..a continental-scale description of soil bacterial communities and the environmental factors influencing their biodiversity. We collected 98 soil samples from across North and South America and used a ribosomal DNA-fingerprinting ..
  25. pmc Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    Les Dethlefsen
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:4554-61. 2011
    ..Antibiotic perturbation may cause a shift to an alternative stable state, the full consequences of which remain unknown...
  26. pmc Exploring microbial diversity and taxonomy using SSU rRNA hypervariable tag sequencing
    Susan M Huse
    Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, Massachusetts, United States of America
    PLoS Genet 4:e1000255. 2008
    ..This technique allows the cost-effective exploration of changes in microbial community structure, including the rare biosphere, over space and time and can be applied immediately to initiatives, such as the Human Microbiome Project...
  27. ncbi Species concepts and species delimitation
    Kevin de Queiroz
    Department of Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560 0162, USA
    Syst Biol 56:879-86. 2007
    ..Fourth, and perhaps most significantly, a unified species concept shifts emphasis away from the traditional species criteria, encouraging biologists to develop new methods of species delimitation that are not tied to those properties...
  28. ncbi A global synthesis reveals biodiversity loss as a major driver of ecosystem change
    David U Hooper
    Department of Biology, Western Washington University, Bellingham, Washington 98225 9160, USA
    Nature 486:105-8. 2012
  29. ncbi Impacts of biodiversity loss on ocean ecosystem services
    Boris Worm
    Department of Biology, Dalhousie University, Halifax, NS, Canada B3H 4J1
    Science 314:787-90. 2006
    ..We analyzed local experiments, long-term regional time series, and global fisheries data to test how biodiversity loss affects marine ecosystem services across temporal and spatial scales...
  30. ncbi Environmental genome shotgun sequencing of the Sargasso Sea
    J Craig Venter
    Institute for Biological Energy Alternatives, 1901 Research Boulevard, Rockville, MD 20850, USA
    Science 304:66-74. 2004
    ..2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors. Variation in species present and stoichiometry suggests substantial oceanic microbial diversity...
  31. ncbi Multivariate dispersion as a measure of beta diversity
    Marti J Anderson
    Ecol Lett 9:683-93. 2006
    ..We propose a new dissimilarity measure which allows the relative weight placed on changes in composition vs. abundance to be specified explicitly...
  32. ncbi Soil bacterial and fungal communities across a pH gradient in an arable soil
    Johannes Rousk
    Department of Microbial Ecology, Lund University, Ecology Building, Lund, Sweden
    ISME J 4:1340-51. 2010
    ..Fungal community composition was less strongly affected by pH, which is consistent with pure culture studies, demonstrating that fungi generally exhibit wider pH ranges for optimal growth...
  33. pmc Pyrosequencing enumerates and contrasts soil microbial diversity
    Luiz F W Roesch
    Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611 0700, USA
    ISME J 1:283-90. 2007
    ..This work is the most comprehensive examination to date of bacterial diversity in soil and suggests that agricultural management of soil may significantly influence the diversity of bacteria and archaea...
  34. ncbi The impact of conservation on the status of the world's vertebrates
    Michael Hoffmann
    IUCN SSC Species Survival Commission, c o United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK
    Science 330:1503-9. 2010
    ..Nonetheless, current conservation efforts remain insufficient to offset the main drivers of biodiversity loss in these groups: agricultural expansion, logging, overexploitation, and invasive alien species.
  35. ncbi Depletion, degradation, and recovery potential of estuaries and coastal seas
    Heike K Lotze
    Biology Department, Dalhousie University, 1355 Oxford Street, Halifax, NS, Canada B3H 4J1
    Science 312:1806-9. 2006
    ..Our results provide detailed historical baselines and quantitative targets for ecosystem-based management and marine conservation...
  36. ncbi Navigating the multiple meanings of β diversity: a roadmap for the practicing ecologist
    Marti J Anderson
    Institute of Information and Mathematical Sciences, Massey University, Albany Campus, Auckland, New Zealand
    Ecol Lett 14:19-28. 2011
    ..We advocate careful consideration of relevant questions, matched by appropriate analyses. The rigorous application of null models will also help to reveal potential processes driving observed patterns in β diversity...
  37. ncbi Accelerated species inventory on Madagascar using coalescent-based models of species delineation
    Michael T Monaghan
    Entomology Department, Natural History Museum, London, UK
    Syst Biol 58:298-311. 2009
    ..This provides a method of species discovery and biodiversity assessment using single-locus data from mixed or environmental samples while building a globally available ..
  38. ncbi Toward an ecological classification of soil bacteria
    Noah Fierer
    Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, Colorado 80309, USA
    Ecology 88:1354-64. 2007
  39. pmc Groundtruthing next-gen sequencing for microbial ecology-biases and errors in community structure estimates from PCR amplicon pyrosequencing
    Charles K Lee
    Department of Biological Sciences, University of Waikato, Hamilton, New Zealand
    PLoS ONE 7:e44224. 2012
    ..Meanwhile, PCR biases associated with the initial amplicon generation may impose greater distortions in the observed community structure...
  40. pmc Assessing the complex sponge microbiota: core, variable and species-specific bacterial communities in marine sponges
    Susanne Schmitt
    Centre for Microbial Innovation, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    ISME J 6:564-76. 2012
    ..This global analysis represents the most comprehensive study of bacterial symbionts in sponges to date and provides novel insights into the complex structure of these unique associations...
  41. ncbi Scenarios for global biodiversity in the 21st century
    Henrique M Pereira
    Centro de Biologia Ambiental, Faculdade de Ciencias da Universidade de Lisboa, 1749 016 Lisboa, Portugal
    Science 330:1496-501. 2010
    ..scenarios are coming of age as a tool for evaluating the impact of future socioeconomic development pathways on biodiversity and ecosystem services...
  42. ncbi Has the Earth's sixth mass extinction already arrived?
    Anthony D Barnosky
    Department of Integrative Biology, University of California, Berkeley, California 94720, USA
    Nature 471:51-7. 2011
    ..Our results confirm that current extinction rates are higher than would be expected from the fossil record, highlighting the need for effective conservation measures...
  43. ncbi The velocity of climate change
    Scott R Loarie
    Carnegie Institution for Science, Department of Global Ecology, Stanford, California 94305, USA
    Nature 462:1052-5. 2009
    ..These results indicate management strategies for minimizing biodiversity loss from climate change. Montane landscapes may effectively shelter many species into the next century...
  44. ncbi Quantifying the evidence for biodiversity effects on ecosystem functioning and services
    Patricia Balvanera
    Centro de Investigaciones en Ecosistemas, UNAM, Morelia, Mexico
    Ecol Lett 9:1146-56. 2006
    Concern is growing about the consequences of biodiversity loss for ecosystem functioning, for the provision of ecosystem services, and for human well being...
  45. pmc How many species are there on Earth and in the ocean?
    Camilo Mora
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS Biol 9:e1001127. 2011
    ..Yet the answer to this question remains enigmatic, as efforts to sample the world's biodiversity to date have been limited and thus have precluded direct quantification of global species richness, and because ..
  46. ncbi Distance-based tests for homogeneity of multivariate dispersions
    Marti J Anderson
    Department of Statistics, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biometrics 62:245-53. 2006
    ..Examples illustrate the utility of the approach, including the analysis of stabilizing selection in sparrows, biodiversity of New Zealand fish assemblages, and the response of Indonesian reef corals to an El Niño...
  47. ncbi Pangloss revisited: a critique of the dilution effect and the biodiversity-buffers-disease paradigm
    S E Randolph
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Parasitology 139:847-63. 2012
    ..diseases (malaria), were driven forward by studies on Lyme borreliosis and have now developed into the mantra "biodiversity protects against disease"...
  48. pmc Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
    Mirjana Rajilić-Stojanović
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
    Environ Microbiol 11:1736-51. 2009
  49. ncbi The status of the world's land and marine mammals: diversity, threat, and knowledge
    Jan Schipper
    International Union for Conservation of Nature IUCN Species Programme, IUCN, 28 Rue Mauverney, 1196 Gland, Switzerland
    Science 322:225-30. 2008
    ..Marine mammals are also disproportionately poorly known. These data are made freely available to support further scientific developments and conservation action...
  50. pmc Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA
    BMC Microbiol 8:125. 2008
    ..We have evaluated the microbiome from the feces of 20 commercial, lactating dairy cows...
  51. pmc Global patterns in bacterial diversity
    Catherine A Lozupone
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 104:11436-40. 2007
    ..This work provides a framework for understanding the impact of environmental factors on bacterial evolution and for the direction of future sequencing efforts to discover new lineages...
  52. ncbi Global biodiversity conservation priorities
    T M Brooks
    Conservation International, 1919 M Street, NW, Washington, DC 20036, USA
    Science 313:58-61. 2006
    The location of and threats to biodiversity are distributed unevenly, so prioritization is essential to minimize biodiversity loss...
  53. pmc Climate change threats to plant diversity in Europe
    Wilfried Thuiller
    Centre d Ecologie Fonctionnelle et Evolutive, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5175, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 102:8245-50. 2005
    ..We found that risks of extinction for European plants may be large, even in moderate scenarios of climate change and despite inter-model variability...
  54. ncbi Microbial biogeography: putting microorganisms on the map
    Jennifer B Hughes Martiny
    Department of Ecology and Evolutionary Biology, 80 Waterman Street, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Microbiol 4:102-12. 2006
    ..However, recent studies also dispute the idea that 'everything is everywhere'. We also consider how the processes that generate and maintain biogeographic patterns in macroorganisms could operate in the microbial world...
  55. ncbi Towards the human intestinal microbiota phylogenetic core
    Julien Tap
    INRA, UEPSD, UR910, 78350 Jouy en Josas, France
    Environ Microbiol 11:2574-84. 2009
    ..Its role in human health deserves further study...
  56. pmc Global patterns of bacterial beta-diversity in seafloor and seawater ecosystems
    Lucie Zinger
    Microbial habitat group, Max Planck Institute for Marine Microbiology, Bremen, Germany
    PLoS ONE 6:e24570. 2011
    Marine microbial communities have been essential contributors to global biomass, nutrient cycling, and biodiversity since the early history of Earth, but so far their community distribution patterns remain unknown in most marine ecosystems...
  57. ncbi The merging of community ecology and phylogenetic biology
    Jeannine Cavender-Bares
    Department of Ecology, Evolution and Behavior, University of Minnesota, St Paul, MN 55108, USA
    Ecol Lett 12:693-715. 2009
    ..Harnessing phylogenetic information to understand and forecast changes in diversity and dynamics of communities is a critical step in managing and restoring the Earth's biota in a time of rapid global change...
  58. pmc Environmental biodiversity, human microbiota, and allergy are interrelated
    Ilkka Hanski
    Department of Biosciences, University of Helsinki, FI 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 109:8334-9. 2012
    Rapidly declining biodiversity may be a contributing factor to another global megatrend--the rapidly increasing prevalence of allergies and other chronic inflammatory diseases among urban populations worldwide...
  59. ncbi Landscape moderation of biodiversity patterns and processes - eight hypotheses
    Teja Tscharntke
    Agroecology, Department of Crop Sciences, Georg August University, Grisebachstrasse 6, 37077 Gottingen, Germany
    Biol Rev Camb Philos Soc 87:661-85. 2012
    Understanding how landscape characteristics affect biodiversity patterns and ecological processes at local and landscape scales is critical for mitigating effects of global environmental change...
  60. pmc Environmental barcoding: a next-generation sequencing approach for biomonitoring applications using river benthos
    Mehrdad Hajibabaei
    Biodiversity Institute of Ontario, Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 6:e17497. 2011
    Timely and accurate biodiversity analysis poses an ongoing challenge for the success of biomonitoring programs...
  61. pmc The biodiversity of the Mediterranean Sea: estimates, patterns, and threats
    Marta Coll
    Institut de Ciencies del Mar, Scientific Spanish Council ICM CSIC, Barcelona, Spain
    PLoS ONE 5:e11842. 2010
    The Mediterranean Sea is a marine biodiversity hot spot...
  62. ncbi Ecological linkages between aboveground and belowground biota
    David A Wardle
    Landcare Research, Post Office Box 69, Lincoln, New Zealand
    Science 304:1629-33. 2004
    ..aboveground-belowground approach to community and ecosystem ecology is enhancing our understanding of the regulation and functional significance of biodiversity and of the environmental impacts of human-induced global change phenomena.
  63. ncbi Effects of species diversity on disease risk
    F Keesing
    Department of Biology, Bard College, PO Box 5000, Annandale, NY 12504, USA
    Ecol Lett 9:485-98. 2006
  64. pmc Bacterial diversity in the oral cavity of 10 healthy individuals
    Elisabeth M Bik
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
    ISME J 4:962-74. 2010
  65. ncbi Effects of biodiversity on the functioning of trophic groups and ecosystems
    Bradley J Cardinale
    Department of Ecology, Evolution and Marine Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA
    Nature 443:989-92. 2006
  66. ncbi Niche conservatism as an emerging principle in ecology and conservation biology
    John J Wiens
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY 11794, USA
    Ecol Lett 13:1310-24. 2010
    ..g. invasives, global warming, tropical richness), and (3) suggests new areas for research (e.g. why are some clades largely nocturnal? why do related species share diseases?)...
  67. ncbi Beyond predictions: biodiversity conservation in a changing climate
    Terence P Dawson
    School of the Environment, University of Dundee, Dundee DD1 4HN, Scotland, UK
    Science 332:53-8. 2011
    Climate change is predicted to become a major threat to biodiversity in the 21st century, but accurate predictions and effective solutions have proved difficult to formulate...
  68. pmc Defining seasonal marine microbial community dynamics
    Jack A Gilbert
    Plymouth Marine Laboratory, Prospect Place, Plymouth, UK
    ISME J 6:298-308. 2012
    ..Interestingly, microbial association network analysis showed that correlations in abundance were stronger within bacterial taxa rather than between bacteria and eukaryotes, or between bacteria and environmental variables...
  69. ncbi Biodiversity improves water quality through niche partitioning
    Bradley J Cardinale
    University of Michigan, School of Natural Resources and Environment, Ann Arbor, Michigan 48109 1041, USA
    Nature 472:86-9. 2011
    ..This has led some to suggest that conservation of biodiversity might be a useful tool for managing nutrient uptake and storage, but this suggestion has been controversial, in ..
  70. pmc Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms
    Jonna Jalanka-Tuovinen
    Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e23035. 2011
    ..The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point...
  71. pmc DNA barcoding Australia's fish species
    Robert D Ward
    CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    Philos Trans R Soc Lond B Biol Sci 360:1847-57. 2005
    ..We conclude that cox1 sequencing, or 'barcoding', can be used to identify fish species...
  72. ncbi Rebuilding global fisheries
    Boris Worm
    Biology Department, Dalhousie University, Halifax, NS B3H 4J1, Canada
    Science 325:578-85. 2009
    ..Impacts of international fleets and the lack of alternatives to fishing complicate prospects for rebuilding fisheries in many poorer regions, highlighting the need for a global perspective on rebuilding marine resources...
  73. pmc DNA barcoding the floras of biodiversity hotspots
    Renaud Lahaye
    Department of Botany and Plant Biotechnology, APK Campus, University of Johannesburg, P O Box 524, Auckland Park 2006, Johannesburg, South Africa
    Proc Natl Acad Sci U S A 105:2923-8. 2008
    ..Here, we undertook intensive field collections in two biodiversity hotspots (Mesoamerica and southern Africa). Using >1,600 samples, we compared eight potential barcodes...
  74. ncbi A renaissance for the pioneering 16S rRNA gene
    Susannah G Tringe
    DOE Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Curr Opin Microbiol 11:442-6. 2008
    ..The standard conclusion that microbial ecosystems are remarkably complex and diverse is now being replaced by detailed insights into microbial ecology and evolution based only on this one historically important marker gene...
  75. ncbi Massively parallel rRNA gene sequencing exacerbates the potential for biased community diversity comparisons due to variable library sizes
    Thomas M Gihring
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 6038, USA
    Environ Microbiol 14:285-90. 2012
    ..The need to equalize the number of reads being compared across libraries is reiterated, and investigators are directed towards available tools for making unbiased diversity comparisons...
  76. ncbi The bacterial species challenge: making sense of genetic and ecological diversity
    Christophe Fraser
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Science 323:741-6. 2009
    ..The resulting data may help to discriminate among the many theories of prokaryotic species that have been produced to date...
  77. ncbi Marine microbial diversity: can it be determined?
    Carlos Pedrós-Alió
    Institut de Ciencies del Mar, CMIMA CSIC, P Marítim de la Barceloneta 37 42, 08003 Barcelona, Spain
    Trends Microbiol 14:257-63. 2006
    ..Despite global dispersal of microorganisms, this number is probably rather large. The total biodiversity of an ecosystem is composed of two elements: first, a set of abundant taxa that carry out most ecosystem ..
  78. ncbi The rational exploration of microbial diversity
    Christopher Quince
    Department of Civil Engineering, University of Glasgow, Glasgow, UK
    ISME J 2:997-1006. 2008
    ..This would initiate a new phase in the exploration of the microbial world...
  79. ncbi Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis
    Anne Salonen
    Department of Basic Veterinary Sciences, Division of Microbiology and Epidemiology, University of Helsinki, P O Box 66, FI 00014, Helsinki, Finland
    J Microbiol Methods 81:127-34. 2010
    ..The assessment of performance differences between different methodologies serves as a concrete step towards the comparison and reliable meta-analysis of the results obtained in different laboratories...
  80. ncbi Genomic and functional adaptation in surface ocean planktonic prokaryotes
    Shibu Yooseph
    J Craig Venter Institute, Rockville, Maryland 20850, USA
    Nature 468:60-6. 2010
    ..Their genomic features also lead us to propose that one method used to avoid predation by viruses and/or bacterivores is by means of slow growth and the maintenance of low biomass...
  81. pmc ESPRIT: estimating species richness using large collections of 16S rRNA pyrosequences
    Yijun Sun
    Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32610 3622, USA
    Nucleic Acids Res 37:e76. 2009
    ..Large-scale experiments are presented that clearly demonstrate the effectiveness of the newly proposed algorithm. The source code and user guide are freely available at
  82. ncbi From plant traits to plant communities: a statistical mechanistic approach to biodiversity
    Bill Shipley
    Departement de Biologie, Universite de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada
    Science 314:812-4. 2006
    We developed a quantitative method, analogous to those used in statistical mechanics, to predict how biodiversity will vary across environments, which plant species from a species pool will be found in which relative abundances in a given ..
  83. pmc Microbial ecology of the dark ocean above, at, and below the seafloor
    Beth N Orcutt
    Department of Biological Sciences, University of Southern California, 3616 Trousdale Blvd, Los Angeles, CA 90089, USA
    Microbiol Mol Biol Rev 75:361-422. 2011
    ..We also focus on patterns of microbial diversity in the dark ocean and on processes and communities that are characteristic of the different habitats...
  84. ncbi GeoChip 3.0 as a high-throughput tool for analyzing microbial community composition, structure and functional activity
    Zhili He
    Institute for Environmental Genomics and Department of Botany and Microbiology, University of Oklahoma, 101 David L Boren Boulevard, Norman, OK 73019, USA
    ISME J 4:1167-79. 2010
    ..As expected, GeoChip 3.0 is a high-throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning...
  85. ncbi DNA barcoding for ecologists
    Alice Valentini
    Laboratoire d Ecologie Alpine, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Trends Ecol Evol 24:110-7. 2009
    ..Short DNA fragments persist in the environment and might allow an assessment of local biodiversity from soil or water. Even DNA-based diet composition can be estimated using fecal samples...
  86. ncbi Computational improvements reveal great bacterial diversity and high metal toxicity in soil
    Jason Gans
    Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87501, USA
    Science 309:1387-90. 2005
    ..Metal pollution reduced diversity more than 99.9%, revealing the highly toxic effect of metal contamination, especially for rare taxa...
  87. pmc The role of DNA barcodes in understanding and conservation of mammal diversity in southeast Asia
    Charles M Francis
    Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada
    PLoS ONE 5:e12575. 2010
    Southeast Asia is recognized as a region of very high biodiversity, much of which is currently at risk due to habitat loss and other threats...
  88. ncbi Genetic diversity and connectivity of deep-sea hydrothermal vent metapopulations
    Robert C Vrijenhoek
    Monterey Bay Aquarium Research Institute, Moss Landing, CA 95039, USA
    Mol Ecol 19:4391-411. 2010
    ..Understanding the diversity and connectivity of vent metapopulations provides essential information for designing deep-sea preserves in regions that are under consideration for submarine mining of precious metals...
  89. ncbi Parallel declines in pollinators and insect-pollinated plants in Britain and the Netherlands
    J C Biesmeijer
    Institute of Integrative and Comparative Biology and Earth and Biosphere Institute, University of Leeds, Leeds, LS2 9JT, UK
    Science 313:351-4. 2006
    ..Taken together, these findings strongly suggest a causal connection between local extinctions of functionally linked plant and pollinator species...
  90. ncbi Biodiversity in a complex world: consolidation and progress in functional biodiversity research
    Helmut Hillebrand
    Institute for Chemistry and Biology of the Marine Environment, Carl von Ossietzky University Oldenburg, Schleusenstrasse 1, 26382 Wilhelmshaven, Germany
    Ecol Lett 12:1405-19. 2009
    The global decline of biodiversity caused by human domination of ecosystems worldwide is supposed to alter important process rates and state variables in these ecosystems...
  91. pmc Emerging infectious disease and the loss of biodiversity in a Neotropical amphibian community
    Karen R Lips
    Department of Zoology, Southern Illinois University, Carbondale, 62901 6501, USA
    Proc Natl Acad Sci U S A 103:3165-70. 2006 an amphibian community at El Copé, Panama, and subsequent mass mortality and loss of amphibian biodiversity across eight families of frogs and salamanders...
  92. ncbi The contribution of species richness and composition to bacterial services
    Thomas Bell
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    Nature 436:1157-60. 2005
    ..b>Biodiversity influences the way in which ecosystems function, but the form of the relationship between bacterial ..
  93. ncbi A serpentinite-hosted ecosystem: the Lost City hydrothermal field
    Deborah S Kelley
    School of Oceanography, University of Washington, Seattle, WA 98195, USA
    Science 307:1428-34. 2005
  94. pmc Spatial distribution and abundances of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) in mangrove sediments
    Meng Li
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, People s Republic of China
    Appl Microbiol Biotechnol 89:1243-54. 2011
    ..The results provide a better understanding on using mangrove wetlands as biological treatment systems for removal of nutrients...
  95. pmc Inferring the dynamics of diversification: a coalescent approach
    Helene Morlon
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 8:. 2010
    Recent analyses of the fossil record and molecular phylogenies suggest that there are fundamental limits to biodiversity, possibly arising from constraints in the availability of space, resources, or ecological niches...
  96. ncbi Global threats to human water security and river biodiversity
    C J Vörösmarty
    The Environmental CrossRoads Initiative, City University of New York, The City College of New York, New York, New York 10035, USA
    Nature 467:555-61. 2010
    ..Here we present the first worldwide synthesis to jointly consider human and biodiversity perspectives on water security using a spatial framework that quantifies multiple stressors and accounts for ..
  97. ncbi Amazonia through time: Andean uplift, climate change, landscape evolution, and biodiversity
    C Hoorn
    Paleoecology and Landscape Ecology, Institute for Biodiversity and Ecosystem Dynamics IBED, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, Netherlands
    Science 330:927-31. 2010
    ..We show that Andean uplift was crucial for the evolution of Amazonian landscapes and ecosystems, and that current biodiversity patterns are rooted deep in the pre-Quaternary.
  98. pmc Quantifying the biodiversity value of tropical primary, secondary, and plantation forests
    J Barlow
    Centre for Ecology, Evolution and Conservation, School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Proc Natl Acad Sci U S A 104:18555-60. 2007
    b>Biodiversity loss from deforestation may be partly offset by the expansion of secondary forests and plantation forestry in the tropics...
  99. pmc Comparative metagenomics of bathypelagic plankton and bottom sediment from the Sea of Marmara
    Achim Quaiser
    Unité d Ecologie, Systematique et Evolution, CNRS UMR8079, Universite Paris Sud 11, Orsay, France
    ISME J 5:285-304. 2011
    ..The Marmara sediment clustered with the soil metagenome, highlighting the common ecological role of both types of microbial communities in the degradation of organic matter and the completion of biogeochemical cycles...
  100. ncbi The unseen majority: soil microbes as drivers of plant diversity and productivity in terrestrial ecosystems
    Marcel G A van der Heijden
    Department of Animal Ecology, Faculty of Earth and Life Sciences, Institute of Ecological Science, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Ecol Lett 11:296-310. 2008
    ..Overall, this review shows that soil microbes must be considered as important drivers of plant diversity and productivity in terrestrial ecosystems...
  101. ncbi Projecting coral reef futures under global warming and ocean acidification
    John M Pandolfi
    Australian Research Council ARC Centre of Excellence for Coral Reef Studies, St Lucia, Queensland 4072, Australia
    Science 333:418-22. 2011

Research Grants63

  1. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: This project will investigate previously inaccessible microbial biodiversity in the deep ocean as novel resources for biomedical discovery...
  2. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    ..All three of these sulfur-focused stresses-soft-metal exposure, disulfide import, and cysteine accumulation-occur under conditions that are likely to exist in natural habitats. ..
  3. Gut micro biota in patients with multiple sclerosis
    Howard L Weiner; Fiscal Year: 2012
    ..It applies for the first time an important newly developing technology to gain potential basic insights into an autoimmune disease whose underlying pathogenesis remains unknown. ..
  4. Pl3K Regulation of Microbicidal Pathways in Macrophages in Experimental Colitis
    Erin C Steinbach; Fiscal Year: 2013
    ..This project will give me a comprehensive background in molecular immunology and microbiology, while applying these skills to the study of a debilitating group of human diseases, the IBDs. ..
  5. Chemical Biodiversity: Investigating the Phylogeny and Functional Toxins of Venom
    MANDE N HOLFORD; Fiscal Year: 2010
    ..phylogeny of the Terebridae [1], the goals of the proposed research are to: I) Document and understand the biodiversity and phylogeny of the Terebridae in the Toxoglossa (Conoidea) super family...
  6. High Performance Validation and Classification of Metagenomic Ribosomal-RNA Seque
    Daniel Frank; Fiscal Year: 2011
    ..and culling of human and chimeric sequences;removal/correction of sequencing errors;accurate assessment of biodiversity;accurate taxonomic classification of sequences;and analysis of microbial eukaryotes in metagenomic specimens...
  7. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..We hypothesize that differences in BD2 GCN affect the host inflammatory response, and thus the propensity to develop disease after infection with H. pylori. ..
  8. EID - Effects of avian migration & anthropogenic change on the distribution & tra
    Thomas Smith; Fiscal Year: 2009
    ..young scientists with the cross-disciplinary, integrative training necessary to address complex issues in biodiversity analysis and conservation...
  9. Creating Collaborative Research Ethics Education with Costa Rica
    Elizabeth Heitman; Fiscal Year: 2010
    Costa Rica's high mean educational level, unique biodiversity, and ongoing improvement of its successful national health system give the country enormous potential for biomedical research...
    Franz Halberg; Fiscal Year: 2012
    ..the mapping of chronomes in selected species, with focus on the relative importance of the biological day vs. the biological week and of the transyear vs. the calendar year. ..
  11. Conservation and Sustainable Use of Biodiversity in PNG
    Louis R Barrows; Fiscal Year: 2013
    ..integrated set of programs dedicated to the description, assessment, rational utilization, and conservation of biodiversity in Papua New Guinea (PNG). PNG is home to approximately 5% of the world's biodiversity...
  12. New Leads Against Cancer and Infectious Diseases from Puerto Rican Reef Species
    Abimael D Rodriguez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This research venture aims to explore Puerto Rican marine biodiversity as a means to discover new and improved anti-cancer and anti-microbial drug candidates, and further seeks to develop these drug ..
  13. ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms
    William H Gerwick; Fiscal Year: 2013
    ..pursuit will be inextricably connected to the development of scientific training and capacity building in a biodiversity-rich yet economically-developing country, and will foster tangible results in biodiversity conservation and ..
  14. Modeling evolution of functional context in proteins
    David D Pollock; Fiscal Year: 2012
    ..In principle, the optimal approach to decoding functional information in protein sequence biodiversity is to use parametric statistical inference with realistic phylogeny-based models...
    Baldomero M Olivera; Fiscal Year: 2013
    ..this discovery strategy represents a potential paradigm shift in how discovery of lead compounds from animal biodiversity will be carried out in the future...
  16. 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
    John J Stegeman; Fiscal Year: 2010
    ..for funding for graduate students and post-docs to attend the 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology...
  17. Exploration, conservation, &development of marine biodiversity in Fiji
    Mark E Hay; Fiscal Year: 2013
    ..the Pacific Islands and United States and for novel bioenergy applications (2) support sustainable uses of the biodiversity upon which such bioprospecting depends, and (3) understand the processes degrading coral reef ecosystems and ..
  18. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2012
    ..Causative therapy of GERD could prevent its progression and reverse the current trend of increasing incidence of EA. ..
  19. Bioactive Compounds from the Biodiversity of Vietnam and Laos
    Djaja D Soejarto; Fiscal Year: 2010
    ..ICBG "Bioactive Compounds") is a modified continuation of the UlC-based Vietnam-Laos ICBG Phase II "Studies on Biodiversity of Vietnam and Laos...
  20. Minimizing the role of cryoprotectant toxicity for cryopreservation
    Utkan Demirci; Fiscal Year: 2013
    ..including tissue engineering, regenerative medicine, stem cells, blood banking, animal strain preservation (biodiversity protection), clinical sample storage, transplantation medicine and in vitro drug testing...
  21. Roots of Rainforest Medicine
    ROBERT ALLEN VOEKS; Fiscal Year: 2010
    ..As Gentry queried, "Is it an impossible dream to hope that through medicinal plants the biodiversity of tropical forests might be able to save the world from cancer or AIDS?" Combined with a legacy of hefty ..
  22. Natural Product Treatments for Leishmaniasis
    Dennis E Kyle; Fiscal Year: 2013
    ..Herein we propose to investigate several niche sources of unstudied or understudied biodiversity in the search for new natural product chemotypes for treating leishmaniasis...
  23. Biodiversity surveys in Indonesia and discovery of health and energy solutions
    Kyria Boundy-Mills; Fiscal Year: 2013 applicant): The simultaneous study, conservation, and sustainable use of natural resources in tropical biodiversity hotspots require collaborative research partnerships of unprecedented scope and complexity, and the alarming ..
  24. The Role of Novel Bacteria in Male Urethritis
    Lisa E Manhart; Fiscal Year: 2012
    ..We will also evaluate behavioral and clinical characteristics associated with detection of novel bacteria, including the clinical response of any organisms associated with NGU to the standard antimicrobial therapies for NGU. ..
  25. Metagenomic study of the human skin microbiome associated with acne
    Huiying Li; Fiscal Year: 2010
    ..Success in this project may lead to the development of new effective therapeutic strategies for treatment of acne. ..
  26. Diversity and stability relationships in the murine microbiome
    PATRICK DAVID SCHLOSS; Fiscal Year: 2013
    ..Toward this goal it is critical to develop a quantitative framework for describing the role of biodiversity in shaping and maintaining the stability of host-associated communities...
  27. High Throughput Microrepository for Genetic Materials
    ROBERT C HAUSHALTER; Fiscal Year: 2012
    ..DNA samples, unique isolated samples, plasmids, forensic samples, patient samples, samples to ensure future biodiversity in plants or animals, clones and archeological samples, a study panel recently convened by NIH NCRR identified ..
  28. Bioassay Guided Isolation of Hypoglycemic Compounds from Philippine Medicinal Pla
    Leah Tolosa; Fiscal Year: 2012
    ..Last, First, Middle): Tolosa, Leah Project Description The Philippines is one of the planet's biodiversity hot spots...
  29. Regenerative Biology Center at the MBL
    Gary G Borisy; Fiscal Year: 2010
    ..The MBL has invested in the cognate areas of cellular dynamics, imaging, genomics, marine husbandry and biodiversity informatics...
    DAVID GEORGE IAN KINGSTON; Fiscal Year: 2013
    The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development, and drug discovery in Madagascar...
  31. Natural Products from Under-explored Microorganisms
    Ben Shen; Fiscal Year: 2012
    ..The criteria for strain selection are: (i) the uniqueness and richness of biodiversity, (ii) symbiosis with traditional Chinese medicinal plants, (iii) morphological and taxonomical distinctiveness, ..
  32. A real-time antibody-based field assay to predict containment bioavailability in
    ..3. Incorporation of mixed analyte beds with differentative antibody specificities for different PAH classes will provide for more accurate discernment of the relative contribution of these different PAHs in the field and laboratory. ..
  33. Diverse drug lead compounds from bacterial symbionts in tropical marine mollusks
    MARGO GENEVIEVE HAYGOOD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Philippine Mollusk Symbiont ICBG (PMS ICBG) project links a biodiversity survey of marine mollusks in one of the world's hotspots of diversity, with drug discovery and enzyme bioprospecting ..
  34. Eighteenth Microbial Genomes Conference
    Jeffrey H Miller; Fiscal Year: 2010
    ..One focus of this conference will be on microbial communities and biodiversity, including the human microbiome...
  35. Community diversity and parasite dynamics
    TODD PHILIP LIVDAHL; Fiscal Year: 2012
    ..The project is relevant to public health from the perspective of managing risks through the management of biodiversity in the human environment...
  36. Discovery of Natural Product based Drugs and Bioenergetic Materials from CR
    David H Sherman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The International Biodiversity Conservation Group (ICBG) program links three key issues, including human health, biodiversity conservation, and economic development by encouraging programs in the U.S...
  37. CSHL Evolution of Caenorhabditis &Other Nematodes Conference
    David J Stewart; Fiscal Year: 2012
    ..evolution of development and reproductive mode, evolution of parasitism and pathogenesis, metagenomics and biodiversity, and computational genomics of both Caenorhabditis and other species of nematodes...
  38. 2012 International Congress on Natural Products Conference
    Edward J Kennelly; Fiscal Year: 2012 disseminate recent research advances in natural products and related fields of herbal medicine, ethnobotany, biodiversity, and nutrition to a global scientific audience...
  39. Tropical Disease Drug Discovery from Marine Cyanobacteria in Panama
    Marcy J Balunas; Fiscal Year: 2011
    ..The International Cooperative Biodiversity Group (ICBG) based in Panama entitled "Ecologically Directed Drug Discovery in Panama" has been involved in a ..
  40. Curricula Modeled on Biodiversity & Vector-Borne Disease
    Leonard E Munstermann; Fiscal Year: 2010
    ..Lyme disease and West Nile encephalitis will serve as model systems for exploring interactions between biodiversity and vector-borne disease under the guiding paradigms provided by national standards for science teaching...
  41. Exploring the Role of Altered Hybrid Recombination in Contributing to Speciation
    LAURIE SHERIE STEVISON; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): A major question in evolutionary biology, determining the genetic source of biodiversity, is best answered by examining species at the interface of speciation - closely related species that are known ..
  42. Molecular Insight into Toxicant Degradation by Microbial Communities
    Gerben Zylstra; Fiscal Year: 2009
    ..However, it is well known that the biodiversity of microorganisms remains relatively untapped with more than 99% of all bacteria in the environment ..
  43. Development of Novel Inhibitors of Clostridium difficile.
    Jane Ryan; Fiscal Year: 2013
    ..The predicted targeting of C. difficile cell division and sporulation by this novel antibiotic is anticipated to provide the added benefits of a reduction in recurrence and transmissibility. ..
    Jennifer J Wernegreen; Fiscal Year: 2010
    ..Since bacteria comprise a substantial fraction of Earth's biodiversity, this signals an enormous gap in our understanding of the processes that shape natural genetic variation...
  45. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    ..If GERD represents a microbiome-related disease, it could be possible to design new antibiotic or probiotic treatment strategies to prevent GERD and reverse the current trend of increasing rate of esophageal adenocarcinoma. ..
  46. New Methodologies for Accelerating Natural Product Discovery
    JOHN ALAN MCLEAN; Fiscal Year: 2012
    ..These two aspects will open up a new reservoir of biodiversity for the discovery of natural products and provide a new method to accelerate the discovery of compounds in ..
  47. Genetics of prezygotic reproductive isolation in natural populations of monk
    DOUGLAS SCHEMSKE; Fiscal Year: 2013
    ..e., the origin of species. All of the biodiversity on Earth, including the origin of humans, is a result of the process of speciation.
  48. Modeling of Hantavirus Reservoirs in Brazil
    Colleen Jonsson; Fiscal Year: 2009
    ..anthropogenic land cover change occurring in Paraguay will have a direct impact of ecosystem viability and biodiversity, and therefore, will affect rodent-hantavirus ecology. From 2003 to present, Brazil has reported 670 cases...
  49. Microbial Ecology and Theory of Animals Center for Excellence in Systems Biology
    KAREN J GUILLEMIN; Fiscal Year: 2013
    ..We will innovate applications of sampling theory, spatial biodiversity theory, and probabilistic models to analyze our data and deduce system-level properties about host-microbe ..
  50. Antibacterial functions of Resistin-like molecule beta in the intestine
    ..Furthermore, these studies will likely contribute to our understanding of how innate immunity contributes to maintaining a healthy and symbiotic intestinal micro biota. ..
  51. Studies of the Flora and Predator Bacteria of Jordan
    NICHOLAS OBERLIES; Fiscal Year: 2004
    This R21 planning application proposes the development of an International Cooperative Biodiversity Group (ICBG) to investigate the biodiversity of the Hashemite Kingdom of Jordan (Jordan) for bioactive lead compounds useful for the ..
  52. Fragment assembly and metabolic/species diversity analysis for Human microbiome p
    Yuzhen Ye; Fiscal Year: 2010
    ..the functional annotation of protein coding genes through database searching, and the characterization of the biodiversity in samples...
  53. Phylogenetic Approach to Plant Allergy Vaccines
    Randall Goldblum; Fiscal Year: 2009
    ..The hypothesis to be tested in this proposal is that the molecular biodiversity of plants can be used to identify natural sources of allergens with reduced capacity to bind IgE, while ..
    Mark Hamann; Fiscal Year: 2007
    ..These areas broadly represent the greatest marine biodiversity available on the planet and a well organized repository of crude extracts, initial column fractions as well as ..
  55. Biodiversity, Habitat Fragmentation, & Lyme Disease Risk
    RICHARD OSTFELD; Fiscal Year: 2006
    ..Our research comprises a rigorous, multidisciplinary approach to understanding the linkages between ecology and risk of infectious disease. ..
  56. Riparian nutrients and food webs on a regulated river
    TERESA TIBBETS; Fiscal Year: 2005
    ..Rivers are not only vital sources of water for agriculture and human consumption, but key areas of biodiversity. The middle Rio Grande river (MRG), which flows through central New Mexico, contains one of the most extensive ..
    Barbara Timmermann; Fiscal Year: 2004
    ..This ICBG has the capabilities to reach the proposed objectives through the application of the latest developments in spectroscopic and spectrometric methods as well as in robotic, micro-instrumentation and computerization. ..
  58. New Drugs from Marine Natural Resources--Jamaican Reefs
    Larry Walker; Fiscal Year: 2004
    ..Jamaica represents a biodiversity hotspot of many important coral reef organisms in the Caribbean, including algae and sponges, which have ..
  59. Drug Development and Biocultural Diversity Conservation
    Paul Cox; Fiscal Year: 2004
    ..programs for the harvesting of Homo/anthus nutans and develop this general capacity for the creation of local biodiversity based sustainable development of phytomedicines...
    Andrew Gordon; Fiscal Year: 1991
    ..Human health implications of the research regard the environmental fate of potentially toxic heavy metals, and, therefore, mechanisms by which they may be incorporated into the food chain...
  61. Ecological Leads: Drugs from Reefs and Microbes in Fiji
    MARK HAY; Fiscal Year: 2004
    ..marine chemists and microbiologists from Scripps Institution of Oceanography, and natural products chemistry, biodiversity conservation, and economic development faculty from the University of the South Pacific to cooperatively ..
  62. Biodiversity and Drug Discovery in the Phillipines
    Michael Kron; Fiscal Year: 2004
    ..The combination of extraordinary terrestrial and marine biodiversity and widespread endangering conditions, places the Philippines in the world's top five high priority ..
    Brian Schuster; Fiscal Year: 2004
    ..richness of this region and its importance as a center for plant endemism makes it a key global center for biodiversity conservation. It is a unique area with great potential as a source of new molecular leads for drug development...