yawning

Summary

Summary: An involuntary deep INHALATION with the MOUTH open, often accompanied by the act of stretching.

Top Publications

  1. pmc Dogs catch human yawns
    Ramiro M Joly-Mascheroni
    School of Psychology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
    Biol Lett 4:446-8. 2008
  2. pmc Yawn contagion and empathy in Homo sapiens
    Ivan Norscia
    Centro Interdipartimentale Museo di Storia Naturale e del Territorio, Universita di Pisa, Calci, Pisa, Italy
    PLoS ONE 6:e28472. 2011
  3. pmc Contagious yawning in gelada baboons as a possible expression of empathy
    E Palagi
    Centro Interdipartimentale Museo di Storia Naturale e del Territorio, Universita di Pisa, 56011 Pisa, Italy
    Proc Natl Acad Sci U S A 106:19262-7. 2009
  4. ncbi Contagious yawning and the brain
    Steven M Platek
    Department of Psychology, Drexel University, 1505 Race Street, Mail Stop 626, Philadelphia, PA 19104, USA
    Brain Res Cogn Brain Res 23:448-52. 2005
  5. doi Why do we yawn?
    Adrian G Guggisberg
    University of Geneva, Department of Clinical Neurosciences, Division of Neurorehabilitation, Avenue de Beau Séjour 26, Geneva 14, Switzerland
    Neurosci Biobehav Rev 34:1267-76. 2010
  6. pmc Ingroup-outgroup bias in contagious yawning by chimpanzees supports link to empathy
    Matthew W Campbell
    Living Links Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e18283. 2011
  7. doi Contagious yawning in autistic and typical development
    Molly S Helt
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Child Dev 81:1620-31. 2010
  8. pmc Neither infants nor toddlers catch yawns from their mothers
    Ailsa Millen
    Department of Psychology, University of Stirling, Stirling FK9 4LA, UK
    Biol Lett 7:440-2. 2011
  9. doi An investigation of auditory contagious yawning
    Stephen R Arnott
    Rotman Research Institute, Toronto, Ontario, Canada
    Cogn Affect Behav Neurosci 9:335-42. 2009
  10. pmc Absence of contagious yawning in children with autism spectrum disorder
    Atsushi Senju
    Centre for Brain and Cognitive Development, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biol Lett 3:706-8. 2007

Research Grants

Detail Information

Publications220 found, 100 shown here

  1. pmc Dogs catch human yawns
    Ramiro M Joly-Mascheroni
    School of Psychology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
    Biol Lett 4:446-8. 2008
    ..Twenty-nine dogs observed a human yawning or making control mouth movements...
  2. pmc Yawn contagion and empathy in Homo sapiens
    Ivan Norscia
    Centro Interdipartimentale Museo di Storia Naturale e del Territorio, Universita di Pisa, Calci, Pisa, Italy
    PLoS ONE 6:e28472. 2011
    ..Related individuals (r≥0.25) showed the greatest contagion, in terms of both occurrence of yawning and frequency of yawns...
  3. pmc Contagious yawning in gelada baboons as a possible expression of empathy
    E Palagi
    Centro Interdipartimentale Museo di Storia Naturale e del Territorio, Universita di Pisa, 56011 Pisa, Italy
    Proc Natl Acad Sci U S A 106:19262-7. 2009
    ..Here, we show that in gelada baboons (Theropithecus gelada) yawning is contagious between individuals, especially those that are socially close, i.e...
  4. ncbi Contagious yawning and the brain
    Steven M Platek
    Department of Psychology, Drexel University, 1505 Race Street, Mail Stop 626, Philadelphia, PA 19104, USA
    Brain Res Cogn Brain Res 23:448-52. 2005
    Contagious yawning, the onset of a yawn triggered by seeing, hearing, reading, or thinking about another person yawn is a well-documented phenomenon...
  5. doi Why do we yawn?
    Adrian G Guggisberg
    University of Geneva, Department of Clinical Neurosciences, Division of Neurorehabilitation, Avenue de Beau Séjour 26, Geneva 14, Switzerland
    Neurosci Biobehav Rev 34:1267-76. 2010
    b>Yawning is a phylogenetically old behaviour that can be observed in most vertebrate species from foetal stages to old age. The origin and function of this conspicuous phenomenon have been subject to speculations for centuries...
  6. pmc Ingroup-outgroup bias in contagious yawning by chimpanzees supports link to empathy
    Matthew W Campbell
    Living Links Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e18283. 2011
    ..However, empathy biases have not been tested in our close primate relatives. Contagious yawning has been theoretically and empirically linked to empathy...
  7. doi Contagious yawning in autistic and typical development
    Molly S Helt
    Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Child Dev 81:1620-31. 2010
    The authors tested susceptibility to contagious yawning in 120 children, 1-6 years, to identify the time course of its emergence during development...
  8. pmc Neither infants nor toddlers catch yawns from their mothers
    Ailsa Millen
    Department of Psychology, University of Stirling, Stirling FK9 4LA, UK
    Biol Lett 7:440-2. 2011
    This study aimed to clarify whether infants and preschool children show susceptibility to contagious yawning, a well-known effect that has been demonstrated experimentally in older children and adults by exposing them to video sequences ..
  9. doi An investigation of auditory contagious yawning
    Stephen R Arnott
    Rotman Research Institute, Toronto, Ontario, Canada
    Cogn Affect Behav Neurosci 9:335-42. 2009
    ..urge to yawn after perceiving someone else yawn, an understanding of the neural mechanism underlying contagious yawning remains incomplete...
  10. pmc Absence of contagious yawning in children with autism spectrum disorder
    Atsushi Senju
    Centre for Brain and Cognitive Development, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biol Lett 3:706-8. 2007
    This study is the first to report the disturbance of contagious yawning in individuals with autism spectrum disorder (ASD)...
  11. ncbi Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia?
    Yoshiko Kasuya
    Division of Anesthesia, Gifu Red Cross Hospital, Japan
    Anesth Analg 101:382-4, table of contents. 2005
    Although yawning occurs frequently during the IV induction of general anesthesia, the significance of this response remains unknown...
  12. pmc Variation and context of yawns in captive chimpanzees (Pan troglodytes)
    Sarah Jane Vick
    Department of Psychology, University of Stirling, Scotland
    Am J Primatol 72:262-9. 2010
    ..some degree of voluntary control over facial movement in chimpanzees and, consequently, multiple functions of yawning according to context...
  13. doi Contagious yawning and the frontal lobe: an fMRI study
    Fatta B Nahab
    Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Brain Mapp 30:1744-51. 2009
    ..These findings suggest a role for the prefrontal cortex in the processing of contagious yawning, while demonstrating a unique automaticity in the processing of contagious motor programs which take place ..
  14. ncbi Yawning in diseases
    Olivier Walusinski
    Eur Neurol 62:180-7. 2009
    b>Yawning is a physiological behavior, an emotional stereotypy that indicates the homeostatic process of the mechanisms regulating rhythms, such as sleeping/waking, hunger/satiety or mating/relaxation, generated by the diencephalon...
  15. doi Auditory contagious yawning in domestic dogs (Canis familiaris): first evidence for social modulation
    Karine Silva
    Departamento de Ciências do Comportamento, Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Largo Prof Abel Salazar 2, Porto, Portugal
    Anim Cogn 15:721-4. 2012
    ..Following recent studies suggesting that contagion yawning in humans, and some other primates, is empathy-related, some authors have considered the possibility that the ..
  16. pmc Male yawning is more contagious than female yawning among chimpanzees (Pan troglodytes)
    Jorg J M Massen
    Department of Behavioural Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e40697. 2012
    ..Contagious yawning may lead to synchronisation of behaviour. However, the function of contagious yawning is relatively understudied...
  17. doi Evidence for contagious behaviors in budgerigars (Melopsittacus undulatus): an observational study of yawning and stretching
    Michael L Miller
    Integrative Neuroscience Program, Department of Psychology, Binghamton University, Binghamton, NY 13902, United States
    Behav Processes 89:264-70. 2012
    b>Yawning is contagious in humans and some non-human primates. If there are social functions to contagious behaviors, such as yawning, they might occur in other highly social vertebrates...
  18. doi Born to yawn? Cortisol linked to yawning: a new hypothesis
    Simon B N Thompson
    Clinical Psychology and Neuropsychology, Psychology Research Centre, Bournemouth University, Poole BH12 5BB, United Kingdom
    Med Hypotheses 77:861-2. 2011
    b>Yawning has become an interesting and curious scientific conundrum. Links between several neurological disorders can be found through the commonality of yawning episodes and contagious yawning...
  19. ncbi Do dogs (Canis familiaris) show contagious yawning?
    Aimee L Harr
    Department of Psychology, Hiram College, 11715 Garfield Road, Hiram, OH 44234 0067, USA
    Anim Cogn 12:833-7. 2009
    We report an experimental investigation into whether domesticated dogs display contagious yawning. Fifteen dogs were shown video clips of (1) humans and (2) dogs displaying yawns and open-mouth expressions (not yawns) to investigate ..
  20. ncbi Yawning and thermoregulation
    Andrew C Gallup
    Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, New York, 13902, United States
    Physiol Behav 95:10-6. 2008
    We review a growing body of medical and physiological evidence indicating that yawning may be a thermoregulatory mechanism, providing compensatory cooling when other provisions fail to operate favorably...
  21. ncbi Yearning to yawn: the neural basis of contagious yawning
    Martin Schürmann
    Brain Research Unit, Low Temperature Laboratory, PO Box 2200, Helsinki University of Technology, 02015 HUT, Espoo, Finland
    Neuroimage 24:1260-4. 2005
    b>Yawning is contagious: Watching another person yawn may trigger us to do the same. Here we studied brain activation with functional magnetic resonance imaging (fMRI) while subjects watched videotaped yawns...
  22. ncbi The functional relationship between yawning and vigilance
    Adrian G Guggisberg
    Center of Sleep Medicine, Department of Neurology, Inselspital, University of Berne, CH 3010 Bern, Switzerland
    Behav Brain Res 179:159-66. 2007
    Although yawning is a ubiquitous and phylogenetically old phenomenon, its origin and purpose remain unclear...
  23. ncbi Does yawning increase arousal through mechanical stimulation of the carotid body?
    Jorma Matikainen
    Department of Chemistry, University of Helsinki, PO Box 55, FIN 00014 Helsinki, Finland
    Med Hypotheses 70:488-92. 2008
    b>Yawning is a stereotyped event that occurs in humans and animals from fish to mammals, but neither its mechanisms nor its functions are entirely known. Its widespread nature suggests that it has important physiological functions...
  24. doi Yawning, sleep, and symptom relief in patients with multiple sclerosis
    Andrew C Gallup
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Sleep Med 11:329-30. 2010
    Patients with multiple sclerosis (MS) suffer from thermoregulatory dysfunction, and repetitive yawning and sleep problems are symptoms of MS...
  25. doi Corticotropin-releasing factor antagonist reduces activation of noradrenalin and serotonin neurons in the locus coeruleus and dorsal raphe in the arousal response accompanied by yawning behavior in rats
    Natsuko Kubota
    Department of Human Health Science, Tokyo Metropolitan University, Japan
    Neurosci Res 72:316-23. 2012
    ..icv) administration of corticotropin-releasing factor (CRF) antagonist attenuates the arousal response during yawning behavior in rats...
  26. ncbi Yawning throughout life
    F Giganti
    Department of Psychology, University of Florence, Florence, Italy
    Front Neurol Neurosci 28:26-31. 2010
    b>Yawning is a behavior that begins in the first stages of life. It has not only been observed in infants and in newborns, but also in fetuses of 12-14 weeks' gestational age. Yawning frequency changes over the life span...
  27. doi Yawning and subjective sleepiness in the elderly
    Iole Zilli
    Sleep Lab, Department of Psychology, University of Florence, Florence, Italy
    J Sleep Res 17:303-8. 2008
    b>Yawning is related to sleep/wake transitions and time of day, probably reflecting the time course of sleepiness...
  28. ncbi Post-ictal forceful yawning in a patient with nondominant hemisphere epilepsy
    Alexei E Yankovsky
    Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada
    Epileptic Disord 8:65-9. 2006
    b>Yawning has been rarely described in association with seizures and not previously documented by video-EEG. We present a 48-year-old woman with a long history of non-dominant for speech hemisphere seizures and post-ictal yawning...
  29. ncbi Yawning?
    Francis Schiller
    Department of the History of the Health Sciences, University of California, San Francisco, CA, USA
    J Hist Neurosci 11:392-401. 2002
    Since antiquity yawning has attracted a moderate interest among philosophers, psychologists, physiologists, as well as educators, moralists and physicians...
  30. pmc Video-induced yawning in stumptail macaques (Macaca arctoides)
    Annika Paukner
    Department of Psychology, University of Stirling, Stirling, FK9 4LA, UK
    Biol Lett 2:36-8. 2006
    This study reports the first experimental exploration of possible contagious yawning in monkeys. Twenty-two stumptail macaques (Macaca arctoides) were presented with video clips of either yawns or control mouth movements by conspecifics...
  31. doi Bridging a yawning chasm: EEG investigations into the debate concerning the role of the human mirror neuron system in contagious yawning
    Nicholas R Cooper
    University of Essex, Colchester, UK
    Cogn Affect Behav Neurosci 12:393-405. 2012
    Ongoing debate in the literature concerns whether there is a link between contagious yawning and the human mirror neuron system (hMNS)...
  32. ncbi An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection
    Ichiro Kita
    Sleep and Circadian Neurobiology Laboratory, Center for Narcolepsy, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5489, USA
    Neurosci Res 54:269-75. 2006
    Intracerebroventricular (ICV) or PVN local injections of oxytocin induce yawning and penile erection, for which a positive feedback mechanism for the PVN oxytocinergic activation is suggested, but this had not been directly substantiated ..
  33. ncbi Brief report: does eye contact induce contagious yawning in children with autism spectrum disorder?
    Atsushi Senju
    Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
    J Autism Dev Disord 39:1598-602. 2009
    Individuals with autism spectrum disorder (ASD) reportedly fail to show contagious yawning, but the mechanism underlying the lack of contagious yawning is still unclear...
  34. doi The dawn of the yawn: is yawning a warning? Linking neurological disorders
    Simon B N Thompson
    Bournemouth University, BH12 5BB, United Kingdom
    Med Hypotheses 75:630-3. 2010
    b>Yawning continues to pose as a scientist's conundrum. Evidence is presented of yawning and contagious yawning in a number of different neurological disorders...
  35. pmc Contagious yawning in chimpanzees
    James R Anderson
    Department of Psychology, University of Stirling, Stirling FK9 4LA, UK
    Proc Biol Sci 271:S468-70. 2004
    Six adult female chimpanzees were shown video scenes of chimpanzees repeatedly yawning or of chimpanzees showing open-mouth facial expressions that were not yawns...
  36. doi Human paranasal sinuses and selective brain cooling: a ventilation system activated by yawning?
    Andrew C Gallup
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, United States
    Med Hypotheses 77:970-3. 2011
    ..The present authors hypothesize that the thin posterior wall of the maxillary sinus may flex during yawning, operating like a bellows pump, actively ventilating the sinus system, and thus facilitating brain cooling...
  37. ncbi Associated diseases
    Olivier Walusinski
    Front Neurol Neurosci 28:140-55. 2010
    b>Yawning is a physiological behavior and, as with all such behaviors, its deregulation is indicative of an underlying disorder...
  38. ncbi Yawn, yawn, yawn, yawn; yawn, yawn, yawn! The social, evolutionary and neuroscientific facets of contagious yawning
    Steven M Platek
    Georgia Gwinnett College, Lawrenceville, GA 30043, USA
    Front Neurol Neurosci 28:107-12. 2010
    Contagious yawning is a common phenomenon affecting upwards of 60% of healthy humans. It has also been observed, at a lesser rate, in great apes and other primates...
  39. ncbi Radiopaque contrast dye in nasopharynx reaches the middle ear during swallowing and/or yawning
    B Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville 22908, USA
    Acta Otolaryngol 125:625-8. 2005
    Contrast dye in the nasopharynx reaches the middle ear during swallowing and yawning in normal adults. This suggests that displacement of bacteria in nasopharyngeal secretion to the middle ear may occur frequently during sleep.
  40. ncbi Yawning frequency and distribution in preterm and near term infants assessed throughout 24-h recordings
    Fiorenza Giganti
    Sleep Lab, Department of Psychology, University of Florence, Italy
    Infant Behav Dev 30:641-7. 2007
    b>Yawning has been observed in foetuses and preterm infants. The aim of this study was to assess the frequency and the 24 h distribution of yawning in preterm infants...
  41. doi Propranolol in yawning prophylaxis: a case report
    Ahmad Ghanizadeh
    Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
    Gen Hosp Psychiatry 34:320.e7-9. 2012
    b>Yawning is a frequent behavior with circadian effects. Sometimes, its frequency is very high and it is disturbing. However, there is no evidence-based treatment for yawning.
  42. pmc Computer animations stimulate contagious yawning in chimpanzees
    Matthew W Campbell
    Living Links Center, Yerkes National Primate Research Center, Emory University, 2409 Taylor Lane, Lawrenceville, GA 30043, USA
    Proc Biol Sci 276:4255-9. 2009
    ..Contagious yawning has been linked to empathy and poses a good test of involuntary identification and motor mimicry...
  43. doi Contagious yawning in domestic dog puppies (Canis lupus familiaris): the effect of ontogeny and emotional closeness on low-level imitation in dogs
    Elainie Alenkær Madsen
    Centre for Languages and Literature, Department of Semiotics, Lund University, Box 201, 221 00, Lund, Sweden
    Anim Cogn 16:233-40. 2013
    Contagious yawning is a well-documented phenomenon in humans and has recently attracted much attention from developmental and comparative sciences...
  44. ncbi Auditory disturbances promote temporal clustering of yawning and stretching in small groups of budgerigars (Melopsittacus undulatus)
    Michael L Miller
    Integrative Neuroscience Program, Psychology Department, Binghamton University, USA
    J Comp Psychol 126:324-8. 2012
    b>Yawning may serve both social and nonsocial functions. When budgerigars (Melopsittacus undulatus) are briefly held, simulating capture by a predator, the temporal pattern of yawning changes...
  45. ncbi Do your patients suffer from excessive yawning?
    A M Gutiérrez-Alvarez
    Faculty of Medicine, Research Office, Universidad del Rosario, Bogota, Colombia
    Acta Psychiatr Scand 115:80-1. 2007
    b>Yawning has been described in relation to drugs such as serotonin reuptake inhibitors, levodopa, dopamine agonists, MAO B inhibitor, morphine, methadone, buprenorphine, dextromethorphan, benzodiazepine, lidocaine, and flecaine...
  46. ncbi Lhermitte sign during yawning associated with congenital partial aplasia of the posterior arch of the atlas
    T Sagiuchi
    Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    AJNR Am J Neuroradiol 27:258-60. 2006
    ..the case of a 26-year-old man who presented with symptoms compatible with Lhermitte sign that occurred during yawning. It was associated with congenital partial aplasia of the posterior arch of the atlas...
  47. ncbi Yawning and behavioral states in premature infants
    Fiorenza Giganti
    Psychology Department, University of Florence, Florence, Italy
    Dev Psychobiol 41:289-96. 2002
    ..PCA) residing in an neonatal intensive care unit environment were observed in the home incubator for spontaneous yawning from 2400 to 0500 hr...
  48. ncbi Contagious yawning: the role of self-awareness and mental state attribution
    Steven M Platek
    Department of Psychology, State University of New York at Albany, Albany, NY, USA
    Brain Res Cogn Brain Res 17:223-7. 2003
    Contagious yawning is a common, but poorly understood phenomenon. We hypothesized that contagious yawning is part of a more general phenomenon known as mental state attribution (i.e...
  49. ncbi [The phylogeny, ethology and nosology of yawning]
    O Walusinski
    Cabinet medical, Brou
    Rev Neurol (Paris) 160:1011-21. 2004
    Charles Darwin would have said that yawning was a useless piece of physiology...
  50. ncbi Fetal yawning
    Olivier Walusinski
    Front Neurol Neurosci 28:32-41. 2010
    ..Using yawning as an example, we review this interpretation on the basis of knowledge derived from phylogeny and ontogeny...
  51. ncbi Primary yawning headache
    D E Jacome
    Department of Medicine, Franklin Medical Center, Greenfield, Masachusetts, USA
    Cephalalgia 21:697-9. 2001
    To describe three patients with recurrent severe paroxysmal headache precipitated by yawning. Pain elicited by yawning is a well-recognized clinical phenomenon in patients with cranial neuralgia, temporomandibular joint dysfunction ..
  52. ncbi Behavioral differences between selectively bred rats: D1 versus D2 receptors in yawning and grooming
    Jose R Eguibar
    Instituto de Fisiologi a, Benemerita Universidad Autonoma de Puebla, Apdo Postal 406, Puebla, Pue C P 72000, Mexico
    Pharmacol Biochem Behav 74:827-32. 2003
    ..D(1) and D(2) receptors, respectively, is involved in behaviors of rats selectively bred for high or low rates of yawning. After injection of SKF 38393, yawning diminished more markedly in high-yawning (HY) than in low-yawning (LY) ..
  53. ncbi Yawning in morning and evening types
    Iole Zilli
    Sleep Lab, Department of Psychology, University of Florence, Via S Niccolò, 93 50125 Florence, Italy
    Physiol Behav 91:218-22. 2007
    b>Yawning occurs more frequently in the early morning and in the late evening, close to sleep onset and after the awakening, and it might be linked to sleep propensity...
  54. ncbi Dislocation of the temporomandibular joint due to forceful yawning during induction with propofol
    Alexander Avidan
    J Clin Anesth 14:159-60. 2002
  55. ncbi Yawning: unsuspected avenue for a better understanding of arousal and interoception
    Olivier Walusinski
    Med Hypotheses 67:6-14. 2006
    Almost all the vertebrates yawn, testifying the phylogenetic old origins of this behavior. Correlatively speaking, yawning shows an ontogenical precociousness since it occurs as early as 12 weeks after conception and remains relatively ..
  56. ncbi Repetitive yawning associated with cardiac tamponade
    Mori J Krantz
    Department of Medicine, Cardiology Division, Denver Health Medical Center, University of Colorado Health Sciences Center, Denver, Colorado 80204 4507, USA
    Am J Cardiol 94:701-2. 2004
    b>Yawning occurs frequently in daily life and is often attributed to boredom and fatigue. Rarely, it may be a symptom of serious underlying medical illness, primarily involving the central nervous system...
  57. doi Intracerebroventricular administration of corticotropin-releasing factor antagonist attenuates arousal response accompanied by yawning behavior in rats
    Ichiro Kita
    Department of Human Health Science, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    Neurosci Lett 433:205-8. 2008
    We have reported that an arousal response accompanied by yawning behavior can be evoked by electrical and chemical stimulation of the hypothalamic paraventricular nucleus (PVN) in rats, although the mechanism responsible for the arousal ..
  58. ncbi The direction and range of ambient temperature change influences yawning in budgerigars (Melopsittacus undulatus)
    Andrew C Gallup
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13901, USA
    J Comp Psychol 124:133-8. 2010
    Comparative research suggests that yawning is a thermoregulatory behavior in homeotherms...
  59. ncbi ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors
    A Argiolas
    Bernard B Brodie Department of Neuroscience, Cagliari University, Cagliari, Italy
    Brain Res Bull 51:425-31. 2000
    ..of adrenocorticotropin (ACTH)(1-24) and alpha-melanocyte stimulating hormone (alpha-MSH) on grooming, stretching, yawning and penile erection was studied after injection into different brain areas...
  60. doi Excessive yawning and thermoregulation: two case histories of chronic, debilitating bouts of yawning
    Gordon G Gallup
    Department of Psychology, University at Albany, Albany, USA
    Sleep Breath 14:157-9. 2010
    This report details the case histories of two women who suffer from chronic and debilitating episodes of excessive yawning in the absence of sleep problems.
  61. ncbi The neuropharmacology of yawning
    A Argiolas
    Bernard B Brodie Department of Neuroscience, University of Cagliari and Center for Neuropharmacology, National Research Council, Italy
    Eur J Pharmacol 343:1-16. 1998
    b>Yawning is a phylogenetically old, stereotyped event that occurs alone or associated with stretching and/or penile erection in humans and in animals from reptiles to birds and mammals under different conditions...
  62. pmc Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists
    Gregory T Collins
    Department of Pharmacology, University of Michigan Medical School, 1301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0632, USA
    Psychopharmacology (Berl) 193:159-70. 2007
    ..Identification of behaviors specifically mediated by the dopamine D2 and D3 receptors would allow for the determination of in vivo receptor selectivity and aide the development of novel therapeutics for dopamine-related diseases...
  63. pmc Pathological yawning as a presenting symptom of brain stem ischaemia in two patients
    L Cattaneo
    Sezione di Neurologia, Dipartimento di Neuroscienze, Universita degli Studi di Parma, Parma, Italy
    J Neurol Neurosurg Psychiatry 77:98-100. 2006
    ..involving the upper pons and the ponto-mesencephalic junction presented with transient excessive pathological yawning, associated with gait ataxia and in one subject with upper limb and facial hemiparesis...
  64. pmc Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior
    Gregory T Collins
    Department of Pharmacology, 1301 MSRB III, University of Michigan Medical School, Ann Arbor, MI 48109 0632, USA
    J Pharmacol Exp Ther 314:310-9. 2005
    ..We now report that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve...
  65. ncbi Two distinctive apomorphine-induced phenotypes in the Roman high- and low-avoidance rats
    Lydia Gimenez-Llort
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Physiol Behav 86:458-66. 2005
    ..The biphasic effect induced by apomorphine (locomotor inhibition and yawning at low doses but stimulation of locomotion and stereotyped behavior at higher ones) was reproduced in the ..
  66. pmc "One person yawning sets off everyone else"
    M Pierre Perriol
    J Neurol Neurosurg Psychiatry 77:3. 2006
  67. ncbi The effects of adulthood nicotine treatment on D2-mediated behavior and neurotrophins of rats neonatally treated with quinpirole
    Russell W Brown
    Department of Psychology, East Tennessee State University, Johnson City, 37614 6049, USA
    Synapse 59:253-9. 2006
    This study was designed to analyze the effects of nicotine on yawning behavior and neurotrophin content in the hippocampus and frontal cortex of D2-receptor primed female adult Sprague-Dawley rats...
  68. ncbi Corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus are involved in arousal/yawning response of rats
    Ichiro Kita
    Department of Physiology, Toho University School of Medicine, 5 21 16 Omori nishi, Ohta ku, Tokyo 143 8540, Japan
    Behav Brain Res 169:48-56. 2006
    ..of the hypothalamic paraventricular (PVN) descending oxytocinergic projections is involved in the induction of yawning accompanied by an arousal response, but the possibility that neural systems other than the oxytocinergic system ..
  69. ncbi Induction of tolerance of dopaminergic responses in man
    S Lal
    Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Verdun, Montreal, QC, Canada, H4H 1R3
    J Neural Transm 115:1189-98. 2008
    ..PRL) and cortisol by radioimmunoassay; sleepiness was measured using the Analog Sleepiness Rating Scale and yawning recorded by video recorder...
  70. ncbi The effects of adulthood olanzapine treatment on cognitive performance and neurotrophic factor content in male and female rats neonatally treated with quinpirole
    Stephanie K Thacker
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    Eur J Neurosci 24:2075-83. 2006
    ..Dopamine D2 receptor priming was verified through a yawning behavioural test, a D2 receptor-mediated event, before olanzapine was administered as well as after olanzapine ..
  71. ncbi Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex
    Amanda M Maple
    Department of Psychology, East Tennessee State University, Johnson City, TN 37614, USA
    Eur J Neurosci 26:2532-8. 2007
    ..1 mg/kg) and the number of yawns was recorded for 1 h after the injection. Yawning has been shown to be a behavioural event mediated by the dopamine D(2)/D(3) receptor...
  72. pmc Can stroke localisation be used to map out the neural network for yawning behaviour?
    Oliver Walusinski
    J Neurol Neurosurg Psychiatry 78:1166. 2007
  73. ncbi Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile erection concomitant with plasma testosterone level reduction in dose- and time-related manner in adult rats
    Lianjun Pan
    Department of Reproduction and Genetics, Nanjing University School of Clinical Medicine, Jinling Hospital, Nanjing, People s Republic of China
    Urology 70:613-7. 2007
    ..The negative effects of phytoestrogens on the male reproductive system, particularly on penile erection, have hardly been evaluated...
  74. ncbi Lack of central nitric oxide triggers erectile dysfunction in diabetes
    Hong Zheng
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1158-64. 2007
    ..N-methyl-D-aspartic acid (NMDA)-induced erection, yawning, and stretch through the PVN can be blocked by prior administration of NO synthase (NOS) blocker, L-NMMA, in ..
  75. ncbi Cortical arousal induced by microinjection of orexins into the paraventricular nucleus of the rat
    Ikuko Sato-Suzuki
    Department of Physiology, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku, Tokyo 143 8540, Japan
    Behav Brain Res 128:169-77. 2002
    ..of the paraventricular nucleus (PVN) in anesthetized, spontaneously breathing rats, and cortical arousal and yawning responses were assessed...
  76. ncbi Bombesin decreases yawning in a high-yawning subline of Sprague-Dawley rats
    Marilú Díaz-Romero
    Instituto de Fisiologia, Benemerita Universidad Autonoma de Puebla, Apdo Postal 406, Puebla, PUE 72000, Mexico
    Pharmacol Biochem Behav 71:103-9. 2002
    ..001, 0.005, 0.1 and 1.0 microg/2 microl on yawning, grooming and other behavioral correlates in two inbred strains of male rats...
  77. ncbi Reduction of drug-induced yawning and penile erection and of noncontact erections in male rats by the activation of GABAA receptors in the paraventricular nucleus: involvement of nitric oxide
    Maria Rosaria Melis
    Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Monserrato Sestu, Km 0 700, 09042 Monserrato CA, Italy
    Eur J Neurosci 15:852-60. 2002
    ..into the paraventricular nucleus (PVN) of the hypothalamus on drug-induced (apomorphine, oxytocin and NMDA) yawning and penile erection, and on the increase in the concentration of NO2- and NO3- occurring in the paraventricular ..
  78. ncbi Adrenalectomy and dexamethasone replacement on yawning behavior
    José Anías-Calderón
    Depto de Fisiologia, Preclínicas Victoria de Girón, Instituto de Ciencias Básicas, Habana, Cuba
    Behav Brain Res 154:255-9. 2004
    b>Yawning, a phylogenetic behavior, present in reptiles, birds and mammals, has been studied for several decades, but to date its physiological function is still unknown...
  79. ncbi The apomorphine test: a biological marker for heroin dependence disorder?
    José Guardia
    Addictive Behavior Unit, Department of Psychiatry, Universitat Autonoma de Barcelona, Hospital de la Santa Creu i Sant Pau, C San Antonio Maria Claret no 167, 08025 Barcelona, Spain
    Addict Biol 7:421-6. 2002
    ..Apomorphine-induced yawning rates were investigated in three different groups; heroin-dependent patients stabilized on d-propoxiphene, heroin-..
  80. ncbi Effects of D3-preferring agonists 7-OH-PIPAT and PD-128,907 on motor behaviors and place conditioning
    T V Khroyan
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Behav Pharmacol 8:65-74. 1997
    ..Locomotion, sniffing, and yawning were measured following the first and last drug injections...
  81. ncbi Light induces cortical activation and yawning in rats
    Yoshinari Seki
    Department of Physiology, Toho University School of Medicine, 5 21 16, Omori Nishi, Ota ku, Tokyo 143 8540, Japan
    Behav Brain Res 140:65-73. 2003
    We examined the effects of light stimulation on cortical activation and yawning response in anesthetized, spontaneously breathing rats...
  82. ncbi Yawning/cortical activation induced by microinjection of histamine into the paraventricular nucleus of the rat
    Yoshinari Seki
    Department of Physiology, Toho University School of Medicine, 5 21 16 Omori nishi, Ohta ku, Tokyo 143 8540, Japan
    Behav Brain Res 134:75-82. 2002
    The effects of microinjection of histamine into the paraventricular nucleus (PVN) of the hypothalamus on yawning responses were investigated in anesthetized, spontaneously breathing rats...
  83. ncbi Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect
    Giorgio Marchese
    Neuroscienze S c a r l, Cagliari, Italy
    Eur J Pharmacol 447:109-14. 2002
    Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low ..
  84. ncbi Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats
    George E Da Silva
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
    Neurosci Lett 349:49-52. 2003
    ..SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxyamide) on penile erection and yawning induced by apomorphine was investigated in rats. SR 141716A (2 mg/kg, i.p...
  85. ncbi Grooming and yawning trace adjustment to unfamiliar environments in laboratory Sprague-Dawley rats (Rattus norvegicus)
    Alejandro Moyaho
    Instituto de Fisiologia, Benemerita Universidad Autonoma de Puebla, Mexico
    J Comp Psychol 116:263-9. 2002
    The authors studied grooming and yawning caused by mild stress in laboratory Sprague-Dawley rats (Rattus norvegicus). Two groups received 3 and 6 sequences of 5 foot shocks at random intervals (RI) and fixed intervals (FI), respectively...
  86. ncbi Dopamine D2 agonist priming in intact and dopamine-lesioned rats
    Richard M Kostrzewa
    Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neurotox Res 6:457-62. 2004
    ....
  87. ncbi Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression
    Russell W Brown
    Department of Psychology, East Tennessee State University, 100 C R Drive, P O Box 70649, Johnson City, TN 37614, USA
    Eur J Neurosci 19:1634-42. 2004
    ..Nicotine alleviates both cognitive and skilled reaching impairments caused by increases in D(2) sensitivity, but the mechanism through which nicotine is acting is currently unknown...
  88. ncbi The effect of electroconvulsive shock seizures on behaviour induced by dopaminergic agonists and on immobility in the Porsolt test
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Eur Neuropsychopharmacol 14:509-14. 2004
    ..They were then tested for locomotion and rearing (7 days post-ECS), for grooming and yawning (9 days post-ECS), and for immobility in the Porsolt test (7, 14 and 21 days post-ECS)...
  89. ncbi Genotype-dependent effect of ACTH1-24 on grooming and yawning in two inbred strains of rats
    Jose R Eguibar
    Instituto de Fisiologia, Benemérita Universidad Autónoma de Puebla Apdo Postal 406 Puebla, Pue CP 72000, Mexico
    Neuropeptides 38:283-8. 2004
    ..administration of ACTH1-24 increases the duration of grooming episodes and the frequency of yawning in rats...
  90. ncbi An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning
    Mark D Lindner
    Department of Neuroscience, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
    J Pharmacol Exp Ther 307:682-91. 2003
    ..The results of our experiments are not consistent with previous reports that suggested that 5-HT6 antagonists might have therapeutic potential for cognitive disorders...
  91. ncbi Enhanced binding of dopamine D1 receptors in caudate-putamen subregions in High-Yawning Sprague-Dawley rats
    Marilú Díaz-Romero
    Instituto de Fisiologia, Benemerita Universidad Autonoma de Puebla, 72570 Puebla, PUE Mexico
    Synapse 56:69-73. 2005
    Previous reports have shown that the inbred High-Yawning (HY) and Low-Yawning (LY) rats differ in several behavioral characteristics related to mesolimbic and nigrostriatal dopamine (DA) function...
  92. pmc Yawning in acute anterior circulation stroke
    Oliver C Singer
    Department of Neurology, JW Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    J Neurol Neurosurg Psychiatry 78:1253-4. 2007
    Pathological yawning can be a clinical sign in disorders affecting the brainstem...
  93. ncbi Video assessment of yawning induced by sublingual apomorphine in migraine
    E Del Bene
    Institute of Internal Medicine and Therapy IV, University of Florence, Italy
    Headache 34:536-8. 1994
    ..placebo-controlled study was carried out in 14 migraineous outpatients and 8 control subjects to assess yawning response to 0.25 mg of sublingual apomorphine, a dopamine receptor agonist, by means of an audiovisual technique...
  94. ncbi [Yawning: from birth to senescence]
    Olivier Walusinski
    Médecine Générale, Brou
    Psychol Neuropsychiatr Vieil 4:39-46. 2006
    b>Yawning is one of the most under-appreciated behaviors. It is a stereotyped and often repetitive motor act, characterized by gaping of the mouth accompanied by a long inspiration, a brief acme followed by a short expiration...
  95. doi Yawning...and why yawns are contagious: a theory on evolution and atavism
    Hari Prasad
    Med Hypotheses 71:307. 2008
  96. ncbi Maternal lead exposure produces long-term enhancement of dopaminergic reactivity in rat offspring
    Grazyna Szczerbak
    Department of Pharmacology, Medical University of Silesia, 41 808, Zabrze, Poland
    Neurochem Res 32:1791-8. 2007
    ..DA D(2) receptor sensitivity developed in Pb(2+) exposed rats, as evidenced by enhanced quinpirole-induced yawning activity and enhanced quinpirole-induced locomotor activity (each, P < 0.05)...
  97. ncbi Substance P and its transglutaminase-synthesized spermine derivative elicit yawning behavior via nitric oxide in rats
    F Mancuso
    Department of Experimental Pharmacology, University of Naples, Federico II, Naples, Italy
    Peptides 22:1453-7. 2001
    ..Here we report that intranigrostriatal injection of SP elicited yawning in rats...
  98. pmc Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat
    B Marcos
    Department of Pharmacology, University of Navarra, Pamplona, Spain
    Br J Pharmacol 155:434-40. 2008
    ....
  99. ncbi Delayed effects of 1,2-epoxypropyltrimethylammonium chloride on behavioral reactions in rats
    Yu G Plyashkevich
    Laboratory of Bioscreening, ASINEKS Company, Moscow
    Bull Exp Biol Med 133:51-3. 2002
    ..Apomorphine-induced yawning increased and orientation and exploratory activity was improved 144 h postinjection, which indicates activation ..
  100. ncbi Paleoneurology: neurodegenerative diseases are age-related diseases of specific brain regions recently developed by Homo sapiens
    J Ghika
    CHCVs, Division of Neurology, Avenue Grand Champsec 80, CH 1951 Sion VS, Switzerland
    Med Hypotheses 71:788-801. 2008
    ..reflexes (sucking, grasping, Babinski/triple retraction, gegenhalten), group alarms (laughter, crying, yawning, grunting...) or grooming (tremor=scratching). (7) Dysautonomia: contextual regulation (orthostatism...)...
  101. ncbi Similar pharmacological properties of 8-OH-DPAT and alnespirone (S 20499) at dopamine receptors: comparison with buspirone
    P Protais
    Laboratoire de Physiologie VACOMED, U F R de Médecine Pharmacie de Rouen, Saint Etienne Rouvray, France
    Eur J Pharmacol 352:179-87. 1998
    ..it displays moderate affinity for dopamine D2 receptors in vitro and it inhibits prolactin release and induces yawning in rats...

Research Grants74

  1. 2nd TMJ Bioengineering Conference
    MICHAEL DETAMORE; Fiscal Year: 2009
    ..10 million Americans, causing agonizing pain and difficulty in simple activities such as eating, talking, and yawning. The purpose of this conference is to develop identify areas of research need and formally present these high ..
  2. Solvent-free engineering of a shape-specific osteochondral TMJ condyle
    MICHAEL DETAMORE; Fiscal Year: 2009
    ..10 million Americans, causing agonizing pain and difficulty in simple activities such as eating, talking, and yawning. An exciting potential solution is tissue engineering, which aims to replace TMJ structures ravaged from trauma ..
  3. Solvent-free engineering of a shape-specific osteochondral TMJ condyle
    MICHAEL SCOTT DETAMORE; Fiscal Year: 2010
    ..10 million Americans, causing agonizing pain and difficulty in simple activities such as eating, talking, and yawning. An exciting potential solution is tissue engineering, which aims to replace TMJ structures ravaged from trauma ..
  4. MASSAGE EFFECTS ON THE DEVELOPMENT OF HIV-EXPOSED BABIES
    Tiffany Field; Fiscal Year: 1993
    ..will be given, and sleep/wake behaviors (including stress behaviors such as facial grimaces, clenched fists, and yawning) will be recorded and heart rate monitored on the first and last days of the study to assess sleep/wake ..
  5. MASSAGING HIV-1-EXPOSED INFANTS
    FRANK SCAFIDI; Fiscal Year: 1993
    ..Sleep/wake behaviors (including stress behaviors such as facial grimaces, clenched fists and yawning) will be recorded and heart rate will be monitored on the first and last days of the study period to assess sleep/..
  6. MASSAGING HIV-1-EXPOSED INFANTS
    FRANK SCAFIDI; Fiscal Year: 1992
    ..Sleep/wake behaviors (including stress behaviors such as facial grimaces, clenched fists and yawning) will be recorded and heart rate will be monitored on the first and last days of the study period to assess sleep/..
  7. DOPAMINE D2 RECEPTORS IN PRIMATE MODELS OF COCAINE ABUSE
    Michael Nader; Fiscal Year: 2009
    ..with the highest D3 affinity will show agonist-like effects on unconditioned behaviors such as drug-induced yawning and locomotor activity...
  8. DOPAMINE D2 RECEPTORS IN PRIMATE MODELS OF COCAINE ABUSE
    Michael A Nader; Fiscal Year: 2010
    ..with the highest D3 affinity will show agonist-like effects on unconditioned behaviors such as drug-induced yawning and locomotor activity...
  9. in vivo characterization of D2/D3 agonists & antagonists
    Gregory Collins; Fiscal Year: 2007
    ..abstract_text> ..
  10. Amphetamine sensitization in a model of schizophrenia
    Russell Brown; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. "Nicotine: Potential therapies and possible pitfalls"
    Russell Brown; Fiscal Year: 2004
    ..Additionally, we plan a final roundtable discussion with all speakers to discuss the commonalities of the positive effects, underlying mechanisms, and adverse effects of nicotine as a potential therapy. ..
  12. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2002
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  13. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2009
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  14. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2001
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  15. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2005
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  16. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2008
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  17. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..A regulatory mechanism is proposed that could lead to a novel treatment in psychiatric illnesses with explosive rage and impulse disorders. ..
  18. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2006
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  19. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  20. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2003
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  21. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  22. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2004
    ..These experiments will (1) further the hypothesis that E and P increase serotonin neural function and (2) initiate investigations of the mechanism of action of E and P in serotonin neurons. ..
  23. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  24. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  25. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    HUNTER contact WESSELLS; Fiscal Year: 2010
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..
  26. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2008
    ..abstract_text> ..
  27. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    HUNTER contact WESSELLS; Fiscal Year: 2010
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..
  28. Uro-EDICII: Risk and Progression of Urologic Complications in Type 1- Diabetes
    Hunter Wessells; Fiscal Year: 2009
    ..The precise data from this study will be important to educate patients and their families, help develop biomarkers of urological complications and provide refined phenotypes for genetic susceptibility studies. ..
  29. Neural Melanocortin Signaling and Erectile Function
    Hunter Wessells; Fiscal Year: 2005
    ..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..
  30. Immortalized Human Cavernosal Endothelial Cells
    Hunter Wessells; Fiscal Year: 2005
    ..abstract_text> ..
  31. Southeastern Michigan Parkinson's Disease Program
    Peter LeWitt; Fiscal Year: 2006
    ..This application also discusses concepts for three pharmacological agents that could be investigated in pilot studies and, if promising, in multicenter clinical trials for assessing neuroprotection. ..
  32. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2006
    ..abstract_text> ..
  33. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2007
    ..abstract_text> ..
  34. Basal ganglia modulation of trigeminal intralaminar nuclei thalamic activity
    Eric Chudler; Fiscal Year: 2007
    ..These studies will help explain the complex sensory symptoms exhibited by patients with PD and may suggest new treatment strategies to alleviate such pain. [unreadable] [unreadable] [unreadable]..
  35. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2001
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  36. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2001
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  37. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2002
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  38. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2002
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  39. INTERNET NEUROSCIENCE RESOURCE - PHASE II
    Eric Chudler; Fiscal Year: 2002
    ..An Internet version of the Neuroscience Resource will continue to be available. An on-line survey and analysis of daily use log files will determine how the Internet Neuroscience Resource is utilized. ..
  40. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2001
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  41. INTERNET NEUROSCIENCE RESOURCE - PHASE II
    Eric Chudler; Fiscal Year: 2001
    ..An Internet version of the Neuroscience Resource will continue to be available. An on-line survey and analysis of daily use log files will determine how the Internet Neuroscience Resource is utilized. ..
  42. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2002
    ..The University of Kansas Parkinson's Disease Center is willing and dedicated to adhere to a common protocol and to cooperate with other centers and NINDS in the conduct of both pilot studies and the main efficacy study. ..
  43. Southeastern Michigan Parkinson's Disease Program
    Peter LeWitt; Fiscal Year: 2002
    ..This application also discusses concepts for three pharmacological agents that could be investigated in pilot studies and, if promising, in multicenter clinical trials for assessing neuroprotection. ..
  44. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2000
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  45. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2004
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  46. INTERNET NEUROSCIENCE RESOURCE - PHASE II
    Eric Chudler; Fiscal Year: 2000
    ..An Internet version of the Neuroscience Resource will continue to be available. An on-line survey and analysis of daily use log files will determine how the Internet Neuroscience Resource is utilized. ..
  47. GENE THERAPY OF DIABETIC PENILE ENDOTHELIAL DYSFUNCTION
    Hunter Wessells; Fiscal Year: 2003
    ..Such a strategy may ultimately be beneficial to men with ED due to diabetes as well as smoking, hypercholesterolemia, and aging. ..
  48. INTERNET NEUROSCIENCE RESOURCE FOR MIDDLE SCHOOL
    Eric Chudler; Fiscal Year: 1999
    ..It is hoped that this project will serve as a model to other scientists and teachers and to encourage them to develop Internet resources in their own areas of expertise for use in the classroom. ..
  49. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2003
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  50. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2002
    ..These data will promote an understanding of GABAergic neurotransmission and abuse liability for a variety of clinically relevant compounds. ..
  51. Delay discounting and fMRI in rhesus monkeys
    CHARLES FRANCE; Fiscal Year: 2008
    ..g., impulsivity) of individuals. ..
  52. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2001
    ..The procedures developed under this grant provide a unique set of conditions for evaluating the effects of other drugs on behaviors related to and predictive of the subjective effects of withdrawal in humans. ..
  53. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2001
    ..Collectively, these studies will provide fundamentally new information on the in vivo pharmacology of GABAA modulators and will help to identify the pharmacologic and behavioral determinants of physical dependence on sedative hypnotics. ..
  54. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2000
    ..The procedures developed under this grant provide a unique set of conditions for evaluating the effects of other drugs on behaviors related to and predictive of the subjective effects of withdrawal in humans. ..
  55. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2003
    ..These data will promote an understanding of GABAergic neurotransmission and abuse liability for a variety of clinically relevant compounds. ..
  56. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2000
    ..The procedures developed under this grant provide a unique set of conditions for evaluating the effects of other drugs on behaviors related to and predictive of the subjective effects of withdrawal in humans. ..
  57. Behavioral Pharmacology of Drug Dependence
    CHARLES FRANCE; Fiscal Year: 2008
    ..This award will allow me to continue spending the majority of my time on NIH-sponsored research and on the expansion of drug abuse research and training at the Health Science Center. ..
  58. GHB abuse--chemistry and neurobiology
    CHARLES FRANCE; Fiscal Year: 2001
    ..abstract_text> ..
  59. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2003
    ..abstract_text> ..
  60. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2004
    ..These data will promote an understanding of GABAergic neurotransmission and abuse liability for a variety of clinically relevant compounds. ..
  61. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2004
    ..abstract_text> ..
  62. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    CHARLES FRANCE; Fiscal Year: 2003
    ....
  63. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2005
    ..These data will promote an understanding of GABAergic neurotransmission and abuse liability for a variety of clinically relevant compounds. ..
  64. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2005
    ..abstract_text> ..
  65. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2006
    ..These data will promote an understanding of GABAergic neurotransmission and abuse liability for a variety of clinically relevant compounds. ..
  66. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2006
    ..abstract_text> ..
  67. GHB abuse: chemistry and neurobiology
    CHARLES FRANCE; Fiscal Year: 2002
    ..abstract_text> ..
  68. Behavioral Pharmacology of Drug Dependence
    CHARLES FRANCE; Fiscal Year: 2007
    ..This award will allow me to continue spending the majority of my time on NIH-sponsored research and on the expansion of drug abuse research and training at the Health Science Center. ..
  69. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2002
    ..The procedures developed under this grant provide a unique set of conditions for evaluating the effects of other drugs on behaviors related to and predictive of the subjective effects of withdrawal in humans. ..
  70. GHB abuse: chemistry and neurobiology
    CHARLES FRANCE; Fiscal Year: 2003
    ..abstract_text> ..
  71. DISCRIMINATIVE EFFECTS OF BENZODIAZEPINE WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2000
    ..Collectively, these studies will provide fundamentally new information on the in vivo pharmacology of GABAA modulators and will help to identify the pharmacologic and behavioral determinants of physical dependence on sedative hypnotics. ..
  72. DISCRIMINATIVE STIMULUS EFFECTS OF OPIOID WITHDRAWAL
    CHARLES FRANCE; Fiscal Year: 2007
    ..abstract_text> ..