respiratory dead space

Summary

Summary: That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.

Top Publications

  1. pmc Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infants
    E H Chung
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
    J Korean Med Sci 16:51-6. 2001
  2. ncbi A prolonged postinspiratory pause enhances CO2 elimination by reducing airway dead space
    Leif Uttman
    Department of Clinical Physiology, University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 23:252-6. 2003
  3. pmc Prospective targeting and control of end-tidal CO2 and O2 concentrations
    Marat Slessarev
    Department of Anaesthesiology, University Health Network, Toronto General Hospital 7EN 242, 200 Elizabeth St, Toronto, Canada, M5G 2C4
    J Physiol 581:1207-19. 2007
  4. ncbi Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects
    Winfried Möller
    Clinical Research Group, Inflammatory Lung Diseases of the GSF, National Research Centre for Environment and Health, Institute for Inhalation Biology, D 82131 Gauting, Germany
    J Appl Physiol (1985) 97:2200-6. 2004
  5. ncbi Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome
    Thomas J Nuckton
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco 94143 0130, USA
    N Engl J Med 346:1281-6. 2002
  6. ncbi Volumetric capnography as a noninvasive diagnostic procedure in acute pulmonary thromboembolism
    Marcos Mello Moreira
    Surgery Department, State University at Campinas School of Medical Sciences, Campinas, Brazil
    J Bras Pneumol 34:328-32. 2008
  7. ncbi Alveolar dead space as a predictor of severity of pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 7:611-7. 2000
  8. ncbi The bedside investigation of pulmonary embolism diagnosis study: a double-blind randomized controlled trial comparing combinations of 3 bedside tests vs ventilation-perfusion scan for the initial investigation of suspected pulmonary embolism
    Marc A Rodger
    University of Ottawa, Ottawa Health Research Institute, and Department of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
    Arch Intern Med 166:181-7. 2006
  9. ncbi Noninvasive measurement of mean alveolar carbon dioxide tension and Bohr's dead space during tidal breathing
    N G Koulouris
    Dept of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, Greece
    Eur Respir J 17:1167-74. 2001
  10. ncbi Pre and post-pulmonary thromboendarterectomies capnographic variables
    Marcos Mello Moreira
    Department of Surgery Faculdade de Ciências Médicas da Universidade Estadual de Campinas
    Rev Bras Cir Cardiovasc 22:509-12. 2007

Research Grants

  1. Respiratory Neurobiology
    Gordon Mitchell; Fiscal Year: 2007
  2. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2007
  3. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
  4. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
  5. Mechanisms of respiratory long-term facilitation
    Gordon Mitchell; Fiscal Year: 2007
  6. Respiratory plasticity and spinal cord Injury
    Gordon Mitchell; Fiscal Year: 2007
  7. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
  8. Mechanisms of respiratory long-term facilitation
    GORDON STEWART MITCHELL; Fiscal Year: 2010
  9. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
  10. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009

Detail Information

Publications151 found, 100 shown here

  1. pmc Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infants
    E H Chung
    Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
    J Korean Med Sci 16:51-6. 2001
    ....
  2. ncbi A prolonged postinspiratory pause enhances CO2 elimination by reducing airway dead space
    Leif Uttman
    Department of Clinical Physiology, University Hospital, Lund, Sweden
    Clin Physiol Funct Imaging 23:252-6. 2003
    ..The objective was to quantify changes in airway dead space (VDaw), slope of the alveolar plateau (SLOPE) and VCO2,T as a function of MDT in healthy pigs...
  3. pmc Prospective targeting and control of end-tidal CO2 and O2 concentrations
    Marat Slessarev
    Department of Anaesthesiology, University Health Network, Toronto General Hospital 7EN 242, 200 Elizabeth St, Toronto, Canada, M5G 2C4
    J Physiol 581:1207-19. 2007
    ..6 l min(-1)). We conclude that targeted end-tidal gas concentrations can be attained in spontaneously breathing subjects using this prospective, feed-forward, low gas flow system...
  4. ncbi Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects
    Winfried Möller
    Clinical Research Group, Inflammatory Lung Diseases of the GSF, National Research Centre for Environment and Health, Institute for Inhalation Biology, D 82131 Gauting, Germany
    J Appl Physiol (1985) 97:2200-6. 2004
    ....
  5. ncbi Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome
    Thomas J Nuckton
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco 94143 0130, USA
    N Engl J Med 346:1281-6. 2002
    ....
  6. ncbi Volumetric capnography as a noninvasive diagnostic procedure in acute pulmonary thromboembolism
    Marcos Mello Moreira
    Surgery Department, State University at Campinas School of Medical Sciences, Campinas, Brazil
    J Bras Pneumol 34:328-32. 2008
    ..The D-dimer test result was positive. Volumetric capnography was performed at admission and after treatment. The values obtained were compared with the imaging test results...
  7. ncbi Alveolar dead space as a predictor of severity of pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Acad Emerg Med 7:611-7. 2000
    ..To determine whether the alveolar dead space volume (V(D)alv), expressed as a percentage of the alveolar tidal volume (V(D)alv/V(T)alv), can predict the degree of vascular occlusion caused by pulmonary embolism (PE)...
  8. ncbi The bedside investigation of pulmonary embolism diagnosis study: a double-blind randomized controlled trial comparing combinations of 3 bedside tests vs ventilation-perfusion scan for the initial investigation of suspected pulmonary embolism
    Marc A Rodger
    University of Ottawa, Ottawa Health Research Institute, and Department of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
    Arch Intern Med 166:181-7. 2006
    ....
  9. ncbi Noninvasive measurement of mean alveolar carbon dioxide tension and Bohr's dead space during tidal breathing
    N G Koulouris
    Dept of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, Greece
    Eur Respir J 17:1167-74. 2001
    ....
  10. ncbi Pre and post-pulmonary thromboendarterectomies capnographic variables
    Marcos Mello Moreira
    Department of Surgery Faculdade de Ciências Médicas da Universidade Estadual de Campinas
    Rev Bras Cir Cardiovasc 22:509-12. 2007
    ..04 and AVDSf was 0.16; for the second patient, the values were 0.07 and 0.28, respectively. The association of these capnographic variables with image exams reinforces the importance of this noninvasive diagnosis method...
  11. ncbi Respiratory dead space measurement in the investigation of pulmonary embolism in outpatients with pleuritic chest pain
    Kerstin Hogg
    Emergency Medicine Research Group, Emergency Department, Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL UK
    Chest 128:2195-202. 2005
    ..Our study aimed to compare the clinical utility of three methods for calculating respiratory dead space in the diagnosis of pulmonary embolism in outpatients with pleuritic chest pain.
  12. pmc The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modelling
    Lisbet Niklason
    Department of Clinical Physiology, University Hospital, Getingevagen 4, SE 221 85 Lund, Sweden
    Crit Care 12:R53. 2008
    ..The purpose of the present study was to analyze the extent to which shunt contributes to alveolar dead space and perturbs carbon dioxide exchange in ancillary physiological disturbances...
  13. ncbi Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method
    Richard H Kallet
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Respir Care 50:462-7. 2005
    ..We investigated the accuracy of volumetric capnography in measuring V(D)/V(T), compared to both uncorrected and corrected measurements, using a metabolic monitor in patients with acute respiratory distress syndrome (ARDS)...
  14. ncbi Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDS
    Umberto Lucangelo
    Department of Perioperative Medicine, Intensive Care and Emergency, Cattinara Hospital, Trieste University School of Medicine, Trieste, Italy
    Chest 133:62-71. 2008
    ..Study population: Thirty-six patients with ALI (Murray score, > or =1; Pao(2)/fraction of inspired oxygen [Fio(2)] ratio, < 300) in critical care departments at two separate hospitals entered the study...
  15. ncbi Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico, Milan, Italy
    Crit Care Med 31:2727-33. 2003
    ..To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)...
  16. ncbi Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome
    Richard H Kallet
    Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco, USA
    Respir Care 49:1008-14. 2004
    ..35 and 0.55. However, VD/VT has seldom been measured with consideration to the evolving pathophysiology of ARDS...
  17. ncbi Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department
    Jeffrey A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
    Ann Emerg Med 44:490-502. 2004
    ..0% of patients with a negative protocol would have an adverse outcome...
  18. pmc Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials
    Hassan Siddiki
    Department of Radiology, Mayo Clinic College of Medicine, 200 1stStreet, Rochester 55905, USA
    Crit Care 14:R141. 2010
    ..The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables...
  19. ncbi Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury
    Magda Cepkova
    Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Chest 132:836-42. 2007
    ....
  20. ncbi Pattern of inspiratory gas delivery affects CO2 elimination in health and after acute lung injury
    Elisabet Aström
    University Hospital, Department of Clinical Physiology, SE 221 85, Lund, Sweden
    Intensive Care Med 34:377-84. 2008
    ..A study was conducted to investigate how MDT affects CO2 elimination in pigs at health and after ALI...
  21. pmc Alveolar dead space and capnographic variables before and after thrombolysis in patients with acute pulmonary embolism
    Marcos Mello Moreira
    Department of Surgery, State University of Campinas, School of Medical Sciences, Campinas, Brazil
    Vasc Health Risk Manag 5:9-12. 2009
    ..Lung scintigraphy was used to compare VCap results from the two subjects with VCap results from healthy volunteers and pigs before and after treatment associated with arterial blood gas, D-dimer, and showed satisfactory agreement...
  22. ncbi CO2 elimination at varying inspiratory pause in acute lung injury
    J Aboab
    Medical Intensive Care Unit, INSERM U492, Hôpital H Mondor, Creteil, France
    Clin Physiol Funct Imaging 27:2-6. 2007
    ..By varying T(P), effects are observed on V(T)CO(2), airway dead space and alveolar PCO(2). These effects depend on perfusion, gas distribution and diffusion in the lung periphery, which need to be further elucidated...
  23. ncbi Aspiration of dead space allows isocapnic low tidal volume ventilation in acute lung injury. Relationships to gas exchange and mechanics
    E De Robertis
    Department of Anaesthesia and Intensive Care, University Federico II, Napoli, Italy
    Intensive Care Med 27:1496-503. 2001
    ..No side effects were noticed. CONCLUSIONS: ASPIDS allowed the use of higher PEEP at lower V(T) and inflation pressure and constant PaCO(2). Multiple Pel/V curves gave insight into the tendency of lungs to collapse...
  24. ncbi Effects of positive end-expiratory pressure on dead space and its partitions in acute lung injury
    L Beydon
    Department of Anaesthesia, University Hospital, 49033 Angers Cedex 01, France
    Intensive Care Med 28:1239-45. 2002
    ..We investigated how physiological, airway and alveolar VD varied with PEEP and analysed possible links to respiratory mechanics...
  25. pmc Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury
    Jérôme Devaquet
    Medical Intensive Care Unit, AP HP, INSERM Unit 841, Centre Hospitalier Albert Chenevier Henri Mondor, Creteil, France
    J Appl Physiol (1985) 105:1944-9. 2008
    ..001) with no significant variation in Pa(O(2)). Postinspiratory pause has a significant influence on CO(2) elimination when small tidal volumes are used during mechanical ventilation for ALI...
  26. ncbi Prognostic value of the pulmonary dead-space fraction during the early and intermediate phases of acute respiratory distress syndrome
    Joan M Raurich
    Intensive Care Unit, Hospital Universitario Son Dureta, 07014, Palma de Mallorca, Illes Balears, Spain
    Respir Care 55:282-7. 2010
    ..We measured the dead-space fraction in the early phase (first week) and the intermediate phase (second week) of ARDS, and evaluated the association of dead-space fraction with mortality...
  27. ncbi [Measurement of the Fowler dead space in patients with pulmonary emphysema using C18O2]
    T Meyer
    GSF, ,
    Pneumologie 55:126-9. 2001
    ..change in airway resistance is caused by obstruction of central airways, which is supposed to reduce the respiratory dead space. Until now, it was not possible to measure the respiratory dead space in patients with lung emphysema ..
  28. ncbi Elimination of ventilator dead space during synchronized ventilation in premature infants
    Nelson Claure
    Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Pediatr 143:315-20. 2003
    ..Mainstream airflow sensors used in neonatal ventilators to synchronize mechanical breaths with spontaneous inspiration and measure ventilation increase dead space and may impair carbon dioxide (CO(2)) elimination...
  29. ncbi Labeled carbon dioxide (C18O2): an indicator gas for phase II in expirograms
    Holger Schulz
    GSF National Research Center for Environment and Health, Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg Munich, Germany
    J Appl Physiol (1985) 97:1755-62. 2004
    ....
  30. ncbi Monitoring dead space during recruitment and PEEP titration in an experimental model
    Gerardo Tusman
    Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
    Intensive Care Med 32:1863-71. 2006
    ..To test the usefulness of dead space for determining open-lung PEEP, the lowest PEEP that prevents lung collapse after a lung recruitment maneuver...
  31. ncbi Unveiling alveolar recruitment: the fascinating trail between theory and practice
    Enrico Calzia
    Intensive Care Med 32:1686-8. 2006
  32. ncbi Validation of an original mathematical model of CO(2) elimination and dead space ventilation
    Jonathan G Hardman
    University Department of Anesthesia, University Hospital, Nottingham, UK
    Anesth Analg 97:1840-5. 2003
    ..6% to 0.8% and PECO(2) -4.9% to 1.2%. This validation allows future application of our model in appropriate theoretical investigations...
  33. ncbi [Cardiopulmonary exercise testing in exercise-induced pulmonary hypertension]
    C Chenivesse
    Clinique des Maladies Respiratoires, Hopital Calmette, CHRU Lille, France
    Rev Mal Respir 23:141-8. 2006
    ..To determine the accuracy of cardiopulmonary exercise-testing (CPET) in detecting exercise-induced pulmonary hypertension...
  34. ncbi Measurement of changes in respiratory mechanics during partial liquid ventilation using jet pulses
    Gerd Schmalisch
    Clinic of Neonatology Charité, Humboldt University Berlin, Germany
    Crit Care Med 31:1435-41. 2003
    ..To compare the changes in respiratory mechanics within the breathing cycle in healthy lungs between gas ventilation and partial liquid ventilation using a special forced-oscillation technique...
  35. ncbi Prone position, carbon dioxide elimination, and survival: a turn for the better?
    Thomas Bein
    Crit Care Med 31:2804-5. 2003
  36. ncbi Tracheal gas insufflation as a lung-protective strategy: physiologic, histologic, and biochemical markers
    Rees E Oliver
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:64-9. 2005
    ..Our objective was to use physiologic, histologic, and biochemical markers to test the hypothesis that tracheal gas insufflation in acute lung injury is lung protective...
  37. ncbi Unevenness of ventilation assessed by the expired CO(2) gas volume versus V(T) curve in asthmatic patients
    N G Koulouris
    Respiratory Function Laboratory, Department of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, 152, Mesogion Ave, Athens GR 11527, Greece
    Respir Physiol Neurobiol 140:293-300. 2004
    ..The change of the above ratios was not related to the percentage decrease of FEV1.0 following methacholine administration...
  38. ncbi Effect of the Y-piece of the ventilation circuit on ventilation requirements in extremely low birth weight infants
    M Wald
    Division of Neonatology and Intensive Care, Department of Pediatrics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Intensive Care Med 31:1095-100. 2005
    ..Yet high tidal volumes are required to overcome dead space. In an experimental arrangement we tested whether reduction of dead space might reduce ventilation requirements and thus reduce volutrauma in preterm infants...
  39. ncbi Exercise response after rapid intravenous infusion of saline in healthy humans
    H Thomas Robertson
    Department of Medicine, University of Washington, Seattle, WA 98195 6522, USA
    J Appl Physiol (1985) 97:697-703. 2004
    ..The reduction in maximal power output, maximal O(2) uptake, and heart rate after saline infusion may be linked to accumulation of edema fluid in exercising muscle, impairing the diffusion of O(2) to muscle mitochondria...
  40. ncbi Tracheal double-lumen ventilation attenuates hypercapnia and respiratory acidosis in lung injured pigs
    Sven Lethvall
    Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, S 413 45 Gothenburg, Sweden
    Intensive Care Med 30:686-92. 2004
    ..Evaluation of ventilatory and circulatory effects with coaxial double-lumen tube ventilation for dead-space reduction as compared with standard endotracheal tube ventilation...
  41. ncbi Differential contribution of dead space ventilation and low arterial pCO2 to exercise hyperpnea in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    Roland Wensel
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Am J Cardiol 93:318-23. 2004
    ..Second, this latter component (depression of arterial pCO(2)) was not related to conventional measures of heart failure severity...
  42. ncbi The dependence of measured alveolar deadspace on anatomical deadspace volume
    I K Moppett
    University Department of Anaesthesia, University Hospital, Nottingham NG7 2UH, UK
    Br J Anaesth 95:400-5. 2005
    ..We sought to quantify the variability in measured VDalv induced by changes in VDanat using a cardiorespiratory computational model...
  43. ncbi [Conditions under which alveolar air equations are modified and the compensation terms of saturated water vapor in those equations]
    Hirofumi Nose
    Department of Anesthesia, Yokohama Ekisaikai Hospital, Yokohama
    Masui 54:427-35. 2005
    ....
  44. ncbi Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury
    Guangfa Zhu
    Department of Respiratory Medicine, Shanghai First People s Hospital, Shanghai, China
    J Appl Physiol 96:1415-24. 2004
    ..either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI...
  45. ncbi Alveolar recruitment improves ventilatory efficiency of the lungs during anesthesia
    Gerardo Tusman
    Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
    Can J Anaesth 51:723-7. 2004
    ..The goal of this study was to analyze the effect of positive end-expiratory pressure (PEEP), with and without a lung recruitment maneuver, on dead space...
  46. ncbi Effects of positive end-expiratory pressure increments can be predicted by computer simulation based on a physiological profile in acute respiratory failure
    L Uttman
    Department of Clinical Physiology, University Hospital, 22185, Lund, Sweden
    Intensive Care Med 29:226-32. 2003
    ..We examined whether computer simulation predicts airway pressures after increments of positive end-expiratory pressure (PEEP) in acute respiratory failure...
  47. ncbi Pressure-controlled versus volume-controlled one-lung ventilation for MIDCAB
    C Heimberg
    Department of Anaesthesiology, Hanover Medical School, Hannover, Germany
    Thorac Cardiovasc Surg 54:516-20. 2006
    ..We conclude that pressure-controlled ventilation may be useful to improve gas exchange and alveolar recruitment during one lung ventilation...
  48. ncbi Pigs are not a reliable experimental model in the study of the haemodynamic and respiratory effects of CO2 pneumoperitoneum
    L Richard
    Department of Anesthesia, Jean Bernard Hospital, University School of Medecine, Poitiers, France
    Acta Anaesthesiol Scand 46:74-9. 2002
    ..The pneumoperitoneum induced a moderate rise in mean arterial pressure (+17%) (P<0.001) without any variation in heart rate, cardiac output and systemic vascular resistances...
  49. ncbi Changes in respiratory function following the intramuscular administration of etorphine to boer goats (Capra hircus)
    P E Buss
    Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
    J S Afr Vet Assoc 72:137-42. 2001
    ..It was not possible to determine how effectively diprenorphine reversed the respiratory effects due to etorphine...
  50. ncbi Short-term modulation of the exercise ventilatory response in young men
    Helen E Wood
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75231, USA
    J Appl Physiol (1985) 104:244-52. 2008
    ..g., with chronic acid-base changes or acute increases in respiratory dead space. When resting ventilation and/or Pa(CO(2)) are altered, maintenance of isocapnia requires active ..
  51. doi Changes in dead space can explain part of the reduction in gas exchange efficiency found, not necessarily linked to respiratory sinus arrhythmia
    Alessandro Beda
    Exp Physiol 93:513-4; author reply 515. 2008
  52. doi The effect of increased apparatus dead space and tidal volumes on carbon dioxide elimination and oxygen saturations in a low-flow anesthesia system
    Bruno J Enekvist
    Department of Anesthesiology and Intensive Care, University Hospital of Lund, 221 85 Lund, Sweden
    J Clin Anesth 20:170-4. 2008
    ..To determine if a large tidal volume (VT), with an unchanged end-tidal carbon dioxide partial pressure (PETco2), could improve arterial carbon dioxide elimination, oxygen saturation (Spo2), and arterial blood oxygenation...
  53. doi The principle of upper airway unidirectional flow facilitates breathing in humans
    Yandong Jiang
    Dept of Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Appl Physiol (1985) 105:854-8. 2008
    ..We suggest this may be the reason that such a breathing pattern is preferred during respiratory distress...
  54. ncbi Changes in respiratory physiological dead space and compliance during non-abdominal, upper abdominal and lower abdominal surgery under general anaesthesia
    T Unoki
    University of Tsukuba, Department of Anesthesiology, Institute of Clinical Medicine, Tsukuba, Ibaraki, Japan
    Eur J Anaesthesiol 21:302-8. 2004
    ....
  55. ncbi [Adjusting background flow in measuring ventilation of newborn infants and infants using the flow-through technique]
    G Schmalisch
    Abteilung Neonatologie,
    Pneumologie 49:461-5. 1995
    ..Therefore, during tidal breathing the background flow should be at least three but not more than the six times VE to avoid an impairment of measurements...
  56. ncbi Early onset of pulmonary gas exchange disturbance during progressive exercise in healthy active men
    B Aguilaniu
    HYLAB, Clinique du Mail, F 38100 Grenoble, France
    J Appl Physiol (1985) 92:1879-84. 2002
    ..Results thus suggest the existence of a common denominator that contributes to the GED of submaximal exercise and affects the maximal ventilatory response...
  57. ncbi Systematic errors and susceptibility to noise of four methods for calculating anatomical dead space from the CO2 expirogram
    Y Tang
    Department of Anaesthetics, Royal Prince Alfred Hospital, University of Sydney, NSW 2050, Sydney, Australia
    Br J Anaesth 98:828-34. 2007
    ..This study assessed systematic errors and susceptibility to noise of the Fowler, Hatch, Cumming, and Bowes dead spaces calculated over 40-80% of the CO2 expirogram...
  58. ncbi Comparison of the effects of heat and moisture exchangers and heated humidifiers on ventilation and gas exchange during non-invasive ventilation
    Samir Jaber
    Unité de Réanimation et de Transplantation Département d Anesthésie Réanimation B, Chu de Montpellier Hopital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex, France
    Intensive Care Med 28:1590-4. 2002
    ..To compare the short-term effects of a heat and moisture exchanger (HME) and a heated humidifier (HH) during non-invasive ventilation (NIV)...
  59. ncbi Dead-space reduction and tracheal pressure measurements using a coaxial inner tube in an endotracheal tube
    S Lethvall
    Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    Intensive Care Med 28:1042-8. 2002
    ..Precision of tracheal pressure monitoring through the DLT and safety issues, including intrinsic PEEP (PEEPi) formation during DLT ventilation, were also evaluated...
  60. ncbi Pulmonary dead space and survival
    Francois Feihl
    N Engl J Med 347:850-2; author reply 850-2. 2002
  61. ncbi End-tidal CO2-derived values during emergency trauma surgery correlated with outcome: a prospective study
    James G Tyburski
    Department of Surgery, Wayne State University, Detroit, Michigan, USA
    J Trauma 53:738-43. 2002
    ..The purpose of this study was to determine whether end-tidal carbon dioxide (PETCO) derived variables assist in evaluating the adequacy of resuscitation during emergency surgery for trauma...
  62. ncbi The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans
    A Raza
    Department of Anatomy, Royal College of Surgeons in Ireland, University College Dublin, Dublin, Ireland
    Respiration 74:533-6. 2007
    ..However, it is not known if CO(2) can transfer from the alveoli to the anatomical dead space of the upper airway during apnoea...
  63. ncbi Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATA
    H J Mummery
    Department of Anesthesiology, Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Appl Physiol 94:507-17. 2003
    ..8 ATA because of wide variability. Older subjects had higher Vd at 1 ATA but similar changes in Vd, Pa(CO(2)), and Pet(CO(2)) at pressure. These results are consistent with an effect of increased gas density...
  64. ncbi Increase in vasopressin concentration and cardiodepressant activity in the blood dialysates from the sella turcica during acute hypoxia
    A Goraca
    Department of Physiology, Institute of Biochemistry, Medical University of Lodz, 90 131 Lodz, Poland
    Endocr Regul 34:127-34. 2000
    ..The aim of present study was to investigate if the cardiodepressant factor and vasopressin are simultaneously released from the pituitary into the blood dialysate during acute hypoxia...
  65. ncbi Tracheostomy in ventilator dependent trauma patients: a prospective, randomized intention-to-treat study
    Erik S Barquist
    Division of Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of Surgery, University of Miami School of Medicine, 9380 SW 150th Street, Ste 100, Miami, FL 33176, USA
    J Trauma 60:91-7. 2006
    ..of ventilator dependence as well as having other benefits such as better patient tolerance and lower respiratory dead space. We conducted a randomized, prospective, single institution study comparing the length ventilator ..
  66. doi Sisters of the sinuses: cetacean air sacs
    Joy S Reidenberg
    Center for Anatomy and Functional Morphology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Anat Rec (Hoboken) 291:1389-96. 2008
    ..they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission.
  67. ncbi A model for evaluation of gas exchange: mouth to mouth ventilation of infants by emergency medical technicians
    R K Kanter
    Department of Pediatrics, State University of New York, Syracuse 13210
    Resuscitation 20:145-51. 1990
    ..20 +/- 0.007. Assuming normal metabolic rate and respiratory dead space, alveolar gas composition resulting from the simulated resuscitations would be PACO2 = 31 +/- 20 and PAO2 =..
  68. ncbi Short-term modulation of the exercise ventilatory response in goats: effects of 8-OH-DPAT and MPPI
    D R Henderson
    Department of Comparative Biosciences, Division of Science and Math, University of Wisconsin, Madison, Wisconsin 53706, USA
    Am J Physiol Regul Integr Comp Physiol 279:R1880-8. 2000
    Increased respiratory dead space increases the exercise ventilatory response, a response known as short-term modulation (STM). We hypothesized that STM results from a spinal, serotonin (5-HT)-dependent mechanism...
  69. doi In vivo and in vitro morphometry of the human trachea
    Kirollos Salah Kamel
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Clin Anat 22:571-9. 2009
    ..The variation in adult tracheal dimensions in vivo is greater than in standard descriptions. These data may be valuable when interpreting chest CT scans and when calculating respiratory dead space.
  70. ncbi Effects of serotonin re-uptake inhibition on ventilatory control in goats
    D R Henderson
    Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
    Respir Physiol 115:1-10. 1999
    ..at rest, during steady-state treadmill exercise, and during successive rest/exercise trials with increased respiratory dead space (0.4-0.6 L). Fluoxetine was administered (> or = 4 weeks, 1 mg/kg, SQ, SID) and protocols were repeated...
  71. ncbi Long term modulation of the leg exercise ventilatory response is not elicited by hypercapnic arm exercise
    D Paul Sumners
    Sport and Exercise Science Research Centre, School of Applied Science, South Bank University, 103 Borough Road, London SE1 0AA, UK
    Respir Physiol Neurobiol 138:107-14. 2003
    ..0+/-4.4), or (b) ten trials of arm cranking exercise paired with external respiratory dead space (1400 ml; V(I)=57.3+/-6.5)...
  72. pmc The effect of a peptide-containing synthetic lung surfactant on gas exchange and lung mechanics in a rabbit model of surfactant depletion
    Johann M van Zyl
    Division of Pharmacology, Cape Town, South Africa
    Drug Des Devel Ther 7:139-48. 2013
    ....
  73. doi Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in healthy adults: implications for dyspnea and exercise tolerance
    Dennis Jensen
    Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada
    Respir Physiol Neurobiol 179:219-26. 2011
    ..Under these circumstances, DSL-induced increases in exertional dyspnea intensity ratings reflected, at least in part, the awareness of increased neural respiratory drive, contractile respiratory muscle effort and ventilatory output...
  74. doi Jet or intensive care unit ventilator during simulated percutaneous transtracheal ventilation: a lung model study
    Y H Liu
    Anaesthesia and Operation Centre, Chinese PLA General Hospital, Beijing, China
    Br J Anaesth 110:456-62. 2013
    ..Our goal was to evaluate the tidal volume (V(T)) generated by a conventional ventilator during simulated PTV compared with PTJV in a lung model...
  75. doi Potential effects of corticosteroids on physiological dead-space fraction in acute respiratory distress syndrome
    Joan M Raurich
    Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain
    Respir Care 57:377-83. 2012
    ..We evaluated the changes in the oxygenation and dead-space fraction in patients with persistent ARDS after corticosteroid therapy...
  76. ncbi Acute hypercapnia and gas exchange in ARDS
    George Findlay
    Chest 130:1950; author reply 1950-1. 2006
  77. ncbi Relationship between physiologic deadspace/tidal volume ratio and gas exchange in infants with acute bronchiolitis on invasive mechanical ventilation
    Armando A Almeida-Junior
    Pediatric Intensive Care Unit, Center for Investigation in Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil
    Pediatr Crit Care Med 8:372-7. 2007
    ....
  78. ncbi Splanchnic hemodynamics and gut mucosal-arterial PCO(2) gradient during systemic hypocapnia
    J A Guzman
    Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Appl Physiol 87:1102-6. 1999
    ..01 for both). Hypocapnia caused ileal mucosal and serosal hypoperfusion, with redistribution of flow favoring the mucosa, accompanied by increased PCO(2) gradient and diminished serosal PO(2)...
  79. ncbi [Respiratory deadspace and compliance measurements in neonates with congenital diaphragmatic hernia]
    R Romero
    Servicio de Cirugia Pediatrica, Unidad de Cuidados Intensivos Neonatales, Hospital Infantil Universitario Gregorio Marañón, C Doctor Castelo, 49, 28009 Madrid
    Cir Pediatr 15:57-62. 2002
    ..Vd/Vt and DC measurement constitute a reliable method to predict outcome in patients with CDH...
  80. doi Is there an optimal breath pattern to minimize stress and strain during mechanical ventilation?
    Josef X Brunner
    Centre Suisse d Electronique et de Microtechnique, Schulstrasse 1, 7302 Landquart, Switzerland
    Intensive Care Med 35:1479-83. 2009
    ..A recent hypothesis is that lung injury is caused by excessive stress and strain. This paper elaborates on that hypothesis and proposes a new approach to optimizing the breath pattern...
  81. ncbi Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apnea
    Rami N Khayat
    University of Wisconsin, Department of Medicine and the Middleton Memorial Veterans Hospital, Madison 53705, USA
    Chest 123:1551-60. 2003
    ..Added dead space (DS) as a form of supplemental CO(2) was effective in eliminating idiopathic CSA. The efficacy and safety of DS has not yet been evaluated in patients with CHF and CSA...
  82. ncbi Acute effects of PEEP on tidal volume and respiratory center output during synchronized ventilation in preterm infants
    Ximena Alegria
    Department of Pediatrics, Division of Newborn Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Pediatr Pulmonol 41:759-64. 2006
    ..An acute increase in PEEP can affect lung mechanics and tidal volume, but it is unknown if these effects elicit compensatory changes in respiratory center output...
  83. ncbi Critique of the equivalent air altitude model
    Johnny Conkin
    Universities Space Research Association, 3600 Bay Area Boulevard, Houston, TX 77058 2769, USA
    Aviat Space Environ Med 79:975-82. 2008
    ..Adjustment through probabilistic statistical modeling to match the current limited experimental observations is one approach to a better isohypoxic model...
  84. ncbi Collateral gas transport by diffusion across tissue in the healthy, human lung; effects on dead space
    S C M Luijendijk
    Department of Pulmonology, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Respir Physiol Neurobiol 133:99-107. 2002
    ..The smallness of this effect means that the alveolar ventilation for Xe hardly benefits from this additional mechanism of intrapulmonary gas mixing...
  85. ncbi A hand-held device to measure oxygen uptake: performance characteristics, patient selection and the propagation of its measurement error into fick cardiac output determinations
    Albert P Shepherd
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Invasive Cardiol 19:113-22. 2007
    ..Our statistical model illustrates strategies to minimize cardiac output error...
  86. ncbi Lesser used tests of pulmonary function: compliance, resistance and dead space
    Steve Kraman
    University of Kentucky College of Medicine, Lexington, KY 40536, USA
    COPD 4:49-54. 2007
    The measurements of lung compliance, airway resistance and respiratory dead space as clinical tests have gradually fallen into disuse as the standard pulmonary function testing procedures; spirometry, lung volume and diffusing capacity ..
  87. ncbi New diagnostic tests for pulmonary embolism
    J A Kline
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Ann Emerg Med 35:168-80. 2000
    ..For comparison, recent data on the diagnostic utility of the alveolar-arterial oxygen gradient and the V/Q scan are included. The potential application of these new tests to a hypothetical ED population is described...
  88. pmc Causes of a high physiological dead space in critically ill patients
    Peter D Wagner
    Division of Physiology, Department of Medicine, University of California at San Diego, 9500 Gilman Drive, 0623A, La Jolla, CA 92093 0623, USA
    Crit Care 12:148. 2008
    ..A solid understanding of respiratory physiology is required to properly interpret physiological dead space in the critically ill...
  89. ncbi A visual aid for teaching ventilation-perfusion relationships
    J M Norton
    Department of Physiology and Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, Maine 04005, USA
    Adv Physiol Educ 24:38-42. 2000
    ..This approach has greatly assisted some students in mastering this traditionally difficult area of respiratory physiology...
  90. ncbi Steady-state end-tidal alveolar dead space measure and D-dimer
    Franck Verschuren
    Chest 121:1373; author reply 1373-4. 2002
  91. ncbi Control of breathing during cortical substitution of the spontaneous automatic respiratory rhythm
    Philippe Haouzi
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, EA 3450, Université H Poincaré, France
    Respir Physiol Neurobiol 159:211-8. 2007
    ..It is suggested that, during volitional control of breathing rhythm, the signal used for adjusting the magnitude to the timing of the ventilatory output is derived from information contained in the duration of preceding expiration...
  92. pmc Volumetric capnography and chronic obstructive pulmonary disease staging
    Pablo V Romero
    Laboratorio de Función Pulmonar, Servicio de Neumologia, Hospital Universitario de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 2:381-91. 2007
    ..We conclude that IAH and IVE can be used when spirometry cannot be reliably performed, as an alternative test to evaluate the degree of functional involvement in COPD patients...
  93. doi Volumetric or time-based capnography for excluding pulmonary embolism in outpatients?
    F Verschuren
    Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Acute Medicine Department, Accidents and Emergency Unit, Brussels, Belgium
    J Thromb Haemost 8:60-7. 2010
    ..Volumetric capnography is technically more demanding but theoretically better than the time-based alveolar deadspace fraction (P(a)CO(2) - EtCO(2))/P(a)CO(2) as a bedside diagnostic tool for excluding pulmonary embolism (PE) in outpatients...
  94. ncbi Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis
    A G Thin
    Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, Dublin Molecular Medicine Centre, University College, Earlsfort Terrace, Dublin, Ireland
    Respir Med 98:1063-70. 2004
    ..Exercise performance in CF might be enhanced by efforts directed at facilitating an increase in exercise tidal volume and therefore the adoption of a more efficient pattern of breathing...
  95. ncbi The influence of physiotherapy and suction on respiratory deadspace in ventilated children
    Eleanor Main
    Centre for Nursing and Allied Health Professionals Research and Physiotherapy Department, Institute of Child Health, 7th Floor, Old Building, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WCIN 3JH, UK
    Intensive Care Med 30:1152-9. 2004
    ....
  96. ncbi Swine model of early adult respiratory distress syndrome induced by intravenous ethchlorvynol
    P J Jebson
    Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City 52242
    Crit Care Med 17:255-60. 1989
    ..PVR increased by 137%, Qsp/Qt by 67%, and VD/VT by 28% over 30 min. These changes were then sustained in the postinfusion period, producing a stable model of early adult respiratory distress syndrome for 3.5 h...
  97. ncbi Dynamic dead space in face masks used with noninvasive ventilators: a lung model study
    E Saatci
    Division of Engineering, King s College London, UK
    Eur Respir J 23:129-35. 2004
    ..5% of tidal volume. Exhaust ports over the nasal bridge in face masks effect important decreases in dynamic dead space provided positive pressure throughout the expiratory phase is used...
  98. pmc Mucociliary and long-term particle clearance in airways of patients with immotile cilia
    Winfried Möller
    Institute for Inhalation Biology, Clinical Research Group Inflammatory Lung Diseases, GSF National Research Centre for Environment and Health, Robert Koch Allee 29, D 82131 Gauting Munich, Germany
    Respir Res 7:10. 2006
    ..This prolonged airway clearance allows longer residence times of bacteria and viruses in the airways and may be one reason for increased frequency of infections in PCD patients...
  99. doi Measurement of dead space in subjects under general anesthesia using standard anesthesia equipment
    John J Badal
    Department of Anesthesiology, University of Arizona, 1501 N Campbell Ave, PO Box 245114, Tucson, AZ 85724 5114, USA
    Anesth Analg 112:375-7. 2011
    ..In this study, we used the bellows PECO(2) measurement and arterial CO(2) (PaCO(2)) to calculate pulmonary dead space. We verified the technique by adding known apparatus dead space volumes during anesthesia...
  100. ncbi The effect of diffusion in the respiratory tree on the alveolar amplitude response technique (AART)
    J P Whiteley
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Respir Physiol Neurobiol 137:81-96. 2003
    ....
  101. ncbi An assessment of dead space in pulmonary ventilation of the toad Bufo schneideri
    M S Fernandes
    Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14 049 900 Ribeirão Preto, SP, Brazil
    Comp Biochem Physiol A Mol Integr Physiol 142:446-50. 2005
    ..These approaches were consistent with a dead space of 30-40% of tidal volume, which indicates a specific pathway for the expired lung gas...

Research Grants66

  1. Respiratory Neurobiology
    Gordon Mitchell; Fiscal Year: 2007
    ..Thus, we propose to continue a training program that meets important goals of the NIH research-training mission. ..
  2. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2007
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
  3. Pretest Probability Assessment for Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
  4. Surrogate markers for Severe Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2005
    ..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
  5. Mechanisms of respiratory long-term facilitation
    Gordon Mitchell; Fiscal Year: 2007
    ....
  6. Respiratory plasticity and spinal cord Injury
    Gordon Mitchell; Fiscal Year: 2007
    ..Further, the conceptual advances promised from these studies may be applicable to other disorders of respiratory control, including neurodegenerative diseases such as ALS. ..
  7. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
    ..A multidisciplinary approach will be used to test key elements of the model. ..
  8. Mechanisms of respiratory long-term facilitation
    GORDON STEWART MITCHELL; Fiscal Year: 2010
    ....
  9. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
    ..Further understanding of mechanism(s) that underlie developmental plasticity with its associated functional impairments may provide the rationale for therapeutic intervention, thereby enhancing functional recovery. ..
  10. Nonlinear Analysis of Heart Rate Variability
    Chi Sang Poon; Fiscal Year: 2009
    ..These clinical and modeling studies in turn will showcase the proposed analytical techniques thereby paving the way for their application to other complex biomedical modeling and analysis problems in general. ..
  11. Nonassociative learning in respiratory control
    Chi Sang Poon; Fiscal Year: 2005
    ....
  12. SYNAPTIC MECHANISMS IN RESPIRATORY CONTROL
    Chi Sang Poon; Fiscal Year: 2002
    ..Five specific aims are proposed to investigate these mechanisms. The results obtained will provide valuable insights into the mechanisms of afferent signal integration in the NTS and the corresponding effects on respiratory control. ..
  13. Integrative Models of Neural Adaptive Control
    Chi Sang Poon; Fiscal Year: 2007
    ....
  14. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ....
  15. Xth Oxford Conference on Modeling and Control of Breathing
    Chi Sang Poon; Fiscal Year: 2006
    ....
  16. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  17. ECG-derived estimators of sleep physiology
    Robert Thomas; Fiscal Year: 2006
    ..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
  18. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2010
    ..Our goal is to determine the function of the sPLA2s in asthma so that novel therapies can be developed and tested in clinical trials that will improve the effectiveness of asthma treatments and alter the natural history of asthma. ..
  19. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2006
    ..abstract_text> ..
  20. WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDY
    Robert Thomas; Fiscal Year: 2006
    ..abstract_text> ..
  21. Neuroendocrine regulation of erythropoiesis following trauma
    Alicia Mohr; Fiscal Year: 2007
    ..This proposal is novel and understanding the neuroendocrine mechanism of erythropoiesis following trauma is a preliminary step towards potential therapeutic modalities for the treatment of anemia. ..
  22. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2007
    ..abstract_text> ..