respiratory dead space
Summary: That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.
Publications147 found, 100 shown here
- Changes in dead space/tidal volume ratio and pulmonary mechanics after surfactant replacement therapy in respiratory distress syndrome of the newborn infantsE H Chung
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea
J Korean Med Sci 16:51-6. 2001....
- A prolonged postinspiratory pause enhances CO2 elimination by reducing airway dead spaceLeif Uttman
Department of Clinical Physiology, University Hospital, Lund, Sweden
Clin Physiol Funct Imaging 23:252-6. 2003..The objective was to quantify changes in airway dead space (VDaw), slope of the alveolar plateau (SLOPE) and VCO2,T as a function of MDT in healthy pigs...
- Prospective targeting and control of end-tidal CO2 and O2 concentrationsMarat Slessarev
Department of Anaesthesiology, University Health Network, Toronto General Hospital 7EN 242, 200 Elizabeth St, Toronto, Canada, M5G 2C4
J Physiol 581:1207-19. 2007..6 l min(-1)). We conclude that targeted end-tidal gas concentrations can be attained in spontaneously breathing subjects using this prospective, feed-forward, low gas flow system...
- Pre and post-pulmonary thromboendarterectomies capnographic variablesMarcos Mello Moreira
Department of Surgery Faculdade de Ciências Médicas da Universidade Estadual de Campinas
Rev Bras Cir Cardiovasc 22:509-12. 2007..04 and AVDSf was 0.16; for the second patient, the values were 0.07 and 0.28, respectively. The association of these capnographic variables with image exams reinforces the importance of this noninvasive diagnosis method...
- Alveolar dead space as a predictor of severity of pulmonary embolismJ A Kline
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
Acad Emerg Med 7:611-7. 2000..To determine whether the alveolar dead space volume (V(D)alv), expressed as a percentage of the alveolar tidal volume (V(D)alv/V(T)alv), can predict the degree of vascular occlusion caused by pulmonary embolism (PE)...
- Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor methodRichard H Kallet
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Respir Care 50:462-7. 2005..We investigated the accuracy of volumetric capnography in measuring V(D)/V(T), compared to both uncorrected and corrected measurements, using a metabolic monitor in patients with acute respiratory distress syndrome (ARDS)...
- Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndromeThomas J Nuckton
Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco 94143 0130, USA
N Engl J Med 346:1281-6. 2002....
- Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injuryJérôme Devaquet
Medical Intensive Care Unit, AP HP, INSERM Unit 841, Centre Hospitalier Albert Chenevier Henri Mondor, Creteil, France
J Appl Physiol 105:1944-9. 2008..001) with no significant variation in Pa(O(2)). Postinspiratory pause has a significant influence on CO(2) elimination when small tidal volumes are used during mechanical ventilation for ALI...
- Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndromeLuciano Gattinoni
Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico, Milan, Italy
Crit Care Med 31:2727-33. 2003..To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)...
- Volumetric capnography as a noninvasive diagnostic procedure in acute pulmonary thromboembolismMarcos Mello Moreira
Surgery Department, State University at Campinas School of Medical Sciences, Campinas, Brazil
J Bras Pneumol 34:328-32. 2008..The D-dimer test result was positive. Volumetric capnography was performed at admission and after treatment. The values obtained were compared with the imaging test results...
- The influence of venous admixture on alveolar dead space and carbon dioxide exchange in acute respiratory distress syndrome: computer modellingLisbet Niklason
Department of Clinical Physiology, University Hospital, Getingevagen 4, SE 221 85 Lund, Sweden
Crit Care 12:R53. 2008..The purpose of the present study was to analyze the extent to which shunt contributes to alveolar dead space and perturbs carbon dioxide exchange in ancillary physiological disturbances...
- Effects of positive end-expiratory pressure on dead space and its partitions in acute lung injuryL Beydon
Department of Anaesthesia, University Hospital, 49033 Angers Cedex 01, France
Intensive Care Med 28:1239-45. 2002..We investigated how physiological, airway and alveolar VD varied with PEEP and analysed possible links to respiratory mechanics...
- Noninvasive measurement of mean alveolar carbon dioxide tension and Bohr's dead space during tidal breathingN G Koulouris
Dept of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, Greece
Eur Respir J 17:1167-74. 2001....
- Aspiration of dead space allows isocapnic low tidal volume ventilation in acute lung injury. Relationships to gas exchange and mechanicsE De Robertis
Department of Anaesthesia and Intensive Care, University Federico II, Napoli, Italy
Intensive Care Med 27:1496-503. 2001..No side effects were noticed. CONCLUSIONS: ASPIDS allowed the use of higher PEEP at lower V(T) and inflation pressure and constant PaCO(2). Multiple Pel/V curves gave insight into the tendency of lungs to collapse...
- Prognostic value of different dead space indices in mechanically ventilated patients with acute lung injury and ARDSUmberto Lucangelo
Department of Perioperative Medicine, Intensive Care and Emergency, Cattinara Hospital, Trieste University School of Medicine, Trieste, Italy
Chest 133:62-71. 2008..Study population: Thirty-six patients with ALI (Murray score, > or =1; Pao(2)/fraction of inspired oxygen [Fio(2)] ratio, < 300) in critical care departments at two separate hospitals entered the study...
- Alveolar dead space and capnographic variables before and after thrombolysis in patients with acute pulmonary embolismMarcos Mello Moreira
Department of Surgery, State University of Campinas, School of Medical Sciences, Campinas, Brazil
Vasc Health Risk Manag 5:9-12. 2009..Lung scintigraphy was used to compare VCap results from the two subjects with VCap results from healthy volunteers and pigs before and after treatment associated with arterial blood gas, D-dimer, and showed satisfactory agreement...
- Respiratory dead space measurement in the investigation of pulmonary embolism in outpatients with pleuritic chest painKerstin Hogg
Emergency Medicine Research Group, Emergency Department, Manchester Royal Infirmary, Oxford Rd, Manchester, M13 9WL UK
Chest 128:2195-202. 2005..Our study aimed to compare the clinical utility of three methods for calculating respiratory dead space in the diagnosis of pulmonary embolism in outpatients with pleuritic chest pain.
- Pattern of inspiratory gas delivery affects CO2 elimination in health and after acute lung injuryElisabet Aström
University Hospital, Department of Clinical Physiology, SE 221 85, Lund, Sweden
Intensive Care Med 34:377-84. 2008..A study was conducted to investigate how MDT affects CO2 elimination in pigs at health and after ALI...
- The bedside investigation of pulmonary embolism diagnosis study: a double-blind randomized controlled trial comparing combinations of 3 bedside tests vs ventilation-perfusion scan for the initial investigation of suspected pulmonary embolismMarc A Rodger
University of Ottawa, Ottawa Health Research Institute, and Department of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada
Arch Intern Med 166:181-7. 2006..CONCLUSION: Excluding PE with at least 2 negative results on 3 bedside tests safely eliminates the need for diagnostic imaging in 34% of patients with suspected PE...
- Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trialsHassan Siddiki
Department of Radiology, Mayo Clinic College of Medicine, 200 1stStreet, Rochester 55905, USA
Crit Care 14:R141. 2010..The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables...
- Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjectsWinfried Möller
Clinical Research Group, Inflammatory Lung Diseases of the GSF, National Research Centre for Environment and Health, Institute for Inhalation Biology, D 82131 Gauting, Germany
J Appl Physiol 97:2200-6. 2004....
- Prognostic value of the pulmonary dead-space fraction during the early and intermediate phases of acute respiratory distress syndromeJoan M Raurich
Intensive Care Unit, Hospital Universitario Son Dureta, 07014, Palma de Mallorca, Illes Balears, Spain
Respir Care 55:282-7. 2010..We measured the dead-space fraction in the early phase (first week) and the intermediate phase (second week) of ARDS, and evaluated the association of dead-space fraction with mortality...
- Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndromeRichard H Kallet
Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco, USA
Respir Care 49:1008-14. 2004..35 and 0.55. However, VD/VT has seldom been measured with consideration to the evolving pathophysiology of ARDS...
- Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency departmentJeffrey A Kline
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28323 2861, USA
Ann Emerg Med 44:490-502. 2004..0% of patients with a negative protocol would have an adverse outcome...
- CO2 elimination at varying inspiratory pause in acute lung injuryJ Aboab
Medical Intensive Care Unit, INSERM U492, Hôpital H Mondor, Creteil, France
Clin Physiol Funct Imaging 27:2-6. 2007..By varying T(P), effects are observed on V(T)CO(2), airway dead space and alveolar PCO(2). These effects depend on perfusion, gas distribution and diffusion in the lung periphery, which need to be further elucidated...
- Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injuryMagda Cepkova
Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
Chest 132:836-42. 2007....
- [Measurement of the Fowler dead space in patients with pulmonary emphysema using C18O2]T Meyer
Pneumologie 55:126-9. 2001..change in airway resistance is caused by obstruction of central airways, which is supposed to reduce the respiratory dead space. Until now, it was not possible to measure the respiratory dead space in patients with lung emphysema ..
- Elimination of ventilator dead space during synchronized ventilation in premature infantsNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
J Pediatr 143:315-20. 2003..Mainstream airflow sensors used in neonatal ventilators to synchronize mechanical breaths with spontaneous inspiration and measure ventilation increase dead space and may impair carbon dioxide (CO(2)) elimination...
- Labeled carbon dioxide (C18O2): an indicator gas for phase II in expirogramsHolger Schulz
GSF National Research Center for Environment and Health, Institute for Inhalation Biology, PO Box 1129, D 85758 Neuherberg Munich, Germany
J Appl Physiol 97:1755-62. 2004....
- Measurement of changes in respiratory mechanics during partial liquid ventilation using jet pulsesGerd Schmalisch
Clinic of Neonatology (Charit, Humboldt-University Berlin, Germany
Crit Care Med 31:1435-41. 2003....
- Systematic errors and susceptibility to noise of four methods for calculating anatomical dead space from the CO2 expirogramY Tang
Department of Anaesthetics, Royal Prince Alfred Hospital, University of Sydney, NSW 2050, Sydney, Australia
Br J Anaesth 98:828-34. 2007..This study assessed systematic errors and susceptibility to noise of the Fowler, Hatch, Cumming, and Bowes dead spaces calculated over 40-80% of the CO2 expirogram...
- Exercise response after rapid intravenous infusion of saline in healthy humansH Thomas Robertson
Department of Medicine, University of Washington, Seattle, WA 98195 6522, USA
J Appl Physiol 97:697-703. 2004..The reduction in maximal power output, maximal O(2) uptake, and heart rate after saline infusion may be linked to accumulation of edema fluid in exercising muscle, impairing the diffusion of O(2) to muscle mitochondria...
- Alveolar recruitment improves ventilatory efficiency of the lungs during anesthesiaGerardo Tusman
Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
Can J Anaesth 51:723-7. 2004..The goal of this study was to analyze the effect of positive end-expiratory pressure (PEEP), with and without a lung recruitment maneuver, on dead space...
- Changes in respiratory physiological dead space and compliance during non-abdominal, upper abdominal and lower abdominal surgery under general anaesthesiaT Unoki
University of Tsukuba, Department of Anesthesiology, Institute of Clinical Medicine, Tsukuba, Ibaraki, Japan
Eur J Anaesthesiol 21:302-8. 2004....
- Tracheal double-lumen ventilation attenuates hypercapnia and respiratory acidosis in lung injured pigsSven Lethvall
Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, S 413 45 Gothenburg, Sweden
Intensive Care Med 30:686-92. 2004..Evaluation of ventilatory and circulatory effects with coaxial double-lumen tube ventilation for dead-space reduction as compared with standard endotracheal tube ventilation...
- Differential contribution of dead space ventilation and low arterial pCO2 to exercise hyperpnea in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathyRoland Wensel
Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, United Kingdom
Am J Cardiol 93:318-23. 2004..Second, this latter component (depression of arterial pCO(2)) was not related to conventional measures of heart failure severity...
- The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humansA Raza
Department of Anatomy, Royal College of Surgeons in Ireland, University College Dublin, Dublin, Ireland
Respiration 74:533-6. 2007..However, it is not known if CO(2) can transfer from the alveoli to the anatomical dead space of the upper airway during apnoea...
- Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injuryGuangfa Zhu
Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai, China
J Appl Physiol 96:1415-24. 2004..either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI...
- Unevenness of ventilation assessed by the expired CO(2) gas volume versus V(T) curve in asthmatic patientsN G Koulouris
Respiratory Function Laboratory, Department of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, 152, Mesogion Ave, Athens GR-11527, Greece
Respir Physiol Neurobiol 140:293-300. 2004..The change of the above ratios was not related to the percentage decrease of FEV1.0 following methacholine administration...
- Prone position, carbon dioxide elimination, and survival: a turn for the better?Thomas Bein
Crit Care Med 31:2804-5. 2003
- Validation of an original mathematical model of CO(2) elimination and dead space ventilationJonathan G Hardman
University Department of Anesthesia, University Hospital, Nottingham, UK
Anesth Analg 97:1840-5. 2003..We validate it against previously published clinical data to allow its use in future theoretical investigations where data may be unavailable from patients...
- Monitoring dead space during recruitment and PEEP titration in an experimental modelGerardo Tusman
Department of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, Argentina
Intensive Care Med 32:1863-71. 2006..To test the usefulness of dead space for determining open-lung PEEP, the lowest PEEP that prevents lung collapse after a lung recruitment maneuver...
- Pressure-controlled versus volume-controlled one-lung ventilation for MIDCABC Heimberg
Department of Anaesthesiology, Hanover Medical School, Hannover, Germany
Thorac Cardiovasc Surg 54:516-20. 2006..We conclude that pressure-controlled ventilation may be useful to improve gas exchange and alveolar recruitment during one lung ventilation...
- Comparison of the effects of heat and moisture exchangers and heated humidifiers on ventilation and gas exchange during non-invasive ventilationSamir Jaber
Unité de Réanimation et de Transplantation Département d Anesthésie Réanimation B, Chu de Montpellier Hopital Saint Eloi, 80 avenue Augustin Fliche, 34295 Montpellier Cedex, France
Intensive Care Med 28:1590-4. 2002..To compare the short-term effects of a heat and moisture exchanger (HME) and a heated humidifier (HH) during non-invasive ventilation (NIV)...
- Unveiling alveolar recruitment: the fascinating trail between theory and practiceEnrico Calzia
Intensive Care Med 32:1686-8. 2006
- Tracheal gas insufflation as a lung-protective strategy: physiologic, histologic, and biochemical markersRees E Oliver
Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
Pediatr Crit Care Med 6:64-9. 2005..Tracheal gas insufflation offers potential as a lung-protective strategy for acute lung injury in the developing rabbit lung and may be a useful clinical adjunct to neonatal respiratory management...
- The principle of upper airway unidirectional flow facilitates breathing in humansYandong Jiang
Dept of Respiratory Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Appl Physiol 105:854-8. 2008..We suggest this may be the reason that such a breathing pattern is preferred during respiratory distress...
- Effects of positive end-expiratory pressure increments can be predicted by computer simulation based on a physiological profile in acute respiratory failureL Uttman
Department of Clinical Physiology, University Hospital, 22185, Lund, Sweden
Intensive Care Med 29:226-32. 2003..We examined whether computer simulation predicts airway pressures after increments of positive end-expiratory pressure (PEEP) in acute respiratory failure...
- [Conditions under which alveolar air equations are modified and the compensation terms of saturated water vapor in those equations]Hirofumi Nose
Department of Anesthesia, Yokohama Ekisaikai Hospital, Yokohama
Masui 54:427-35. 2005....
- The dependence of measured alveolar deadspace on anatomical deadspace volumeI K Moppett
University Department of Anaesthesia, University Hospital, Nottingham NG7 2UH, UK
Br J Anaesth 95:400-5. 2005..This has implications for the interpretation of deadspace measured in the clinical setting. The variability is less for the ratio VDalv/VTfresh...
- Effect of the Y-piece of the ventilation circuit on ventilation requirements in extremely low birth weight infantsM Wald
Division of Neonatology and Intensive Care, Department of Pediatrics, Medical University of Vienna, , 1090 Vienna, Austria
Intensive Care Med 31:1095-100. 2005..7 and 10.9%, respectively); thus, we think that introduction of the innovative dead-space free-flow sensor into clinical practice might reduce incidence and severity of bronchopulmonary dysplasia by reduction of volutrauma...
- [Adjusting background flow in measuring ventilation of newborn infants and infants using the flow-through technique]G Schmalisch
Pneumologie 49:461-5. 1995..Therefore, during tidal breathing the background flow should be at least three but not more than the six times VE to avoid an impairment of measurements...
- Changes in respiratory function following the intramuscular administration of etorphine to boer goats (Capra hircus)P E Buss
Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
J S Afr Vet Assoc 72:137-42. 2001..It was not possible to determine how effectively diprenorphine reversed the respiratory effects due to etorphine...
- Pigs are not a reliable experimental model in the study of the haemodynamic and respiratory effects of CO2 pneumoperitoneumL Richard
Department of Anesthesia, Jean Bernard Hospital, University School of Medecine, Poitiers, France
Acta Anaesthesiol Scand 46:74-9. 2002..The pneumoperitoneum induced a moderate rise in mean arterial pressure (+17%) (P<0.001) without any variation in heart rate, cardiac output and systemic vascular resistances...
- End-tidal CO2-derived values during emergency trauma surgery correlated with outcome: a prospective studyJames G Tyburski
Department of Surgery, Wayne State University, Detroit, Michigan, USA
J Trauma 53:738-43. 2002..The purpose of this study was to determine whether end-tidal carbon dioxide (PETCO) derived variables assist in evaluating the adequacy of resuscitation during emergency surgery for trauma...
- Effects of age and exercise on physiological dead space during simulated dives at 2.8 ATAH J Mummery
Department of Anesthesiology, Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Appl Physiol 94:507-17. 2003..8 ATA because of wide variability. Older subjects had higher Vd at 1 ATA but similar changes in Vd, Pa(CO(2)), and Pet(CO(2)) at pressure. These results are consistent with an effect of increased gas density...
- Short-term modulation of the exercise ventilatory response in young menHelen E Wood
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center Dallas, Dallas, Texas 75231, USA
J Appl Physiol 104:244-52. 2008..g., with chronic acid-base changes or acute increases in respiratory dead space. When resting ventilation and/or Pa(CO(2)) are altered, maintenance of isocapnia requires active ..
- Pulmonary dead space and survivalFrancois Feihl
N Engl J Med 347:850-2; author reply 850-2. 2002
- Dead-space reduction and tracheal pressure measurements using a coaxial inner tube in an endotracheal tubeS Lethvall
Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, , Sweden
Intensive Care Med 28:1042-8. 2002..CONCLUSIONS: The double lumen tube is as effective as tracheal gas insufflation in reducing CO(2) tension. Tracheal pressure and formation of PEEPi can be monitored with high precision without interrupting ventilation...
- The effect of increased apparatus dead space and tidal volumes on carbon dioxide elimination and oxygen saturations in a low-flow anesthesia systemBruno J Enekvist
Department of Anesthesiology and Intensive Care, University Hospital of Lund, 221 85 Lund, Sweden
J Clin Anesth 20:170-4. 2008..To determine if a large tidal volume (VT), with an unchanged end-tidal carbon dioxide partial pressure (PETco2), could improve arterial carbon dioxide elimination, oxygen saturation (Spo2), and arterial blood oxygenation...
- [Cardiopulmonary exercise testing in exercise-induced pulmonary hypertension]C Chenivesse
Clinique des Maladies Respiratoires, , CHRU Lille, France
Rev Mal Respir 23:141-8. 2006..CONCLUSION: Patients with exercise-induced PH did not decrease or may increase dead space during exercise. Therefore CPET may be a useful tool in selecting patients who need to undergo further exercise haemodynamic investigations...
- Early onset of pulmonary gas exchange disturbance during progressive exercise in healthy active menB Aguilaniu
HYLAB, Clinique du Mail, F 38100 Grenoble, France
J Appl Physiol 92:1879-84. 2002..Results thus suggest the existence of a common denominator that contributes to the GED of submaximal exercise and affects the maximal ventilatory response...
- Changes in dead space can explain part of the reduction in gas exchange efficiency found, not necessarily linked to respiratory sinus arrhythmiaAlessandro Beda
Exp Physiol 93:513-4; author reply 515. 2008
- Increase in vasopressin concentration and cardiodepressant activity in the blood dialysates from the sella turcica during acute hypoxiaA Goraca
Department of Physiology, Institute of Biochemistry, Medical University of Lodz, 90 131 Lodz, Poland
Endocr Regul 34:127-34. 2000..The aim of present study was to investigate if the cardiodepressant factor and vasopressin are simultaneously released from the pituitary into the blood dialysate during acute hypoxia...
- Tracheostomy in ventilator dependent trauma patients: a prospective, randomized intention-to-treat studyErik S Barquist
Division of Trauma and Surgical Critical Care, DeWitt Daughtry Family Department of Surgery, University of Miami School of Medicine, 9380 SW 150th Street, Ste 100, Miami, FL 33176, USA
J Trauma 60:91-7. 2006..of ventilator dependence as well as having other benefits such as better patient tolerance and lower respiratory dead space. We conducted a randomized, prospective, single institution study comparing the length ventilator ..
- Sisters of the sinuses: cetacean air sacsJoy S Reidenberg
Center for Anatomy and Functional Morphology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Anat Rec (Hoboken) 291:1389-96. 2008..they may subserve unique aquatic functions, such as increasing inspiratory volume, mitigating pressure-induced volume change, air shunting to reduce respiratory dead space, and facilitating underwater sound production and transmission.
- A model for evaluation of gas exchange: mouth to mouth ventilation of infants by emergency medical techniciansR K Kanter
Department of Pediatrics, State University of New York, Syracuse 13210
Resuscitation 20:145-51. 1990..20 +/- 0.007. Assuming normal metabolic rate and respiratory dead space, alveolar gas composition resulting from the simulated resuscitations would be PACO2 = 31 +/- 20 and PAO2 =..
- Short-term modulation of the exercise ventilatory response in goats: effects of 8-OH-DPAT and MPPID R Henderson
Department of Comparative Biosciences, Division of Science and Math, University of Wisconsin, Madison, Wisconsin 53706, USA
Am J Physiol Regul Integr Comp Physiol 279:R1880-8. 2000Increased respiratory dead space increases the exercise ventilatory response, a response known as short-term modulation (STM). We hypothesized that STM results from a spinal, serotonin (5-HT)-dependent mechanism...
- In vivo and in vitro morphometry of the human tracheaKirollos Salah Kamel
Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
Clin Anat 22:571-9. 2009..The variation in adult tracheal dimensions in vivo is greater than in standard descriptions. These data may be valuable when interpreting chest CT scans and when calculating respiratory dead space.
- Long term modulation of the leg exercise ventilatory response is not elicited by hypercapnic arm exerciseD Paul Sumners
Sport and Exercise Science Research Centre, School of Applied Science, South Bank University, 103 Borough Road, London SE1 0AA, UK
Respir Physiol Neurobiol 138:107-14. 2003..0+/-4.4), or (b) ten trials of arm cranking exercise paired with external respiratory dead space (1400 ml; V(I)=57.3+/-6.5)...
- Effects of serotonin re-uptake inhibition on ventilatory control in goatsD R Henderson
Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA
Respir Physiol 115:1-10. 1999..at rest, during steady-state treadmill exercise, and during successive rest/exercise trials with increased respiratory dead space (0.4-0.6 L). Fluoxetine was administered (> or = 4 weeks, 1 mg/kg, SQ, SID) and protocols were repeated...
- Volumetric or time-based capnography for excluding pulmonary embolism in outpatients?F Verschuren
Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Acute Medicine Department, Accidents and Emergency Unit, Brussels, Belgium
J Thromb Haemost 8:60-7. 2010..Volumetric capnography is technically more demanding but theoretically better than the time-based alveolar deadspace fraction (P(a)CO(2) - EtCO(2))/P(a)CO(2) as a bedside diagnostic tool for excluding pulmonary embolism (PE) in outpatients...
- Influence of cycling history on the ventilatory response to cycle-ergometry in humans: a role for respiratory memory?Andrew J Cathcart
Centre for Exercise Science and Medicine, University of Glasgow, Glasgow, UK
Adv Exp Med Biol 669:311-4. 2010..In conclusion, these findings provide no support for, and possibly support for no, V'E control during moderate exercise being modulated by influences related to long-term exercise history...
- Estimation of dead space fraction can be simplified in the acute respiratory distress syndromeDavide Chiumello
Dipartimento di Anestesia, Rianimazione e Terapia del Dolore, Fondazione IRCCS, Ca Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, Milan, Italy
Crit Care 14:195. 2010....
- Mucociliary and long-term particle clearance in airways of patients with immotile ciliaWinfried Möller
Institute for Inhalation Biology, Clinical Research Group Inflammatory Lung Diseases, GSF National Research Centre for Environment and Health, Robert Koch Allee 29, D 82131 Gauting Munich, Germany
Respir Res 7:10. 2006..This prolonged airway clearance allows longer residence times of bacteria and viruses in the airways and may be one reason for increased frequency of infections in PCD patients...
- Measurement of dead space in subjects under general anesthesia using standard anesthesia equipmentJohn J Badal
Department of Anesthesiology, University of Arizona, 1501 N Campbell Ave, PO Box 245114, Tucson, AZ 85724 5114, USA
Anesth Analg 112:375-7. 2011..In this study, we used the bellows PECO(2) measurement and arterial CO(2) (PaCO(2)) to calculate pulmonary dead space. We verified the technique by adding known apparatus dead space volumes during anesthesia...
- Deadspace: invasive or not?G B Drummond
Br J Anaesth 96:4-7. 2006
- Acute hypercapnia and gas exchange in ARDSGeorge Findlay
Chest 130:1950; author reply 1950-1. 2006
- Acute effects of PEEP on tidal volume and respiratory center output during synchronized ventilation in preterm infantsXimena Alegria
Department of Pediatrics, Division of Newborn Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Pediatr Pulmonol 41:759-64. 2006..An acute increase in PEEP can affect lung mechanics and tidal volume, but it is unknown if these effects elicit compensatory changes in respiratory center output...
- A hand-held device to measure oxygen uptake: performance characteristics, patient selection and the propagation of its measurement error into fick cardiac output determinationsAlbert P Shepherd
Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
J Invasive Cardiol 19:113-22. 2007..Our statistical model illustrates strategies to minimize cardiac output error...
- Lesser used tests of pulmonary function: compliance, resistance and dead spaceSteve Kraman
University of Kentucky College of Medicine, Lexington, KY 40536, USA
COPD 4:49-54. 2007The measurements of lung compliance, airway resistance and respiratory dead space as clinical tests have gradually fallen into disuse as the standard pulmonary function testing procedures; spirometry, lung volume and diffusing capacity ..
- Relationship between physiologic deadspace/tidal volume ratio and gas exchange in infants with acute bronchiolitis on invasive mechanical ventilationArmando A Almeida-Junior
Pediatric Intensive Care Unit, Center for Investigation in Pediatrics, State University of Campinas Medical School, Campinas, SP, Brazil
Pediatr Crit Care Med 8:372-7. 2007....
- Control of breathing during cortical substitution of the spontaneous automatic respiratory rhythmPhilippe Haouzi
Laboratoire de Physiologie, Faculte de Medecine de Nancy, EA 3450, Université H Poincaré, France
Respir Physiol Neurobiol 159:211-8. 2007..It is suggested that, during volitional control of breathing rhythm, the signal used for adjusting the magnitude to the timing of the ventilatory output is derived from information contained in the duration of preceding expiration...
- Volumetric capnography and chronic obstructive pulmonary disease stagingPablo V Romero
Laboratorio de Función Pulmonar, Servicio de Neumologia, Hospital Universitario de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
Int J Chron Obstruct Pulmon Dis 2:381-91. 2007..We conclude that IAH and IVE can be used when spirometry cannot be reliably performed, as an alternative test to evaluate the degree of functional involvement in COPD patients...
- Causes of a high physiological dead space in critically ill patientsPeter D Wagner
Division of Physiology, Department of Medicine, University of California at San Diego, 9500 Gilman Drive, 0623A, La Jolla, CA 92093 0623, USA
Crit Care 12:148. 2008..A solid understanding of respiratory physiology is required to properly interpret physiological dead space in the critically ill...
- Is there an optimal breath pattern to minimize stress and strain during mechanical ventilation?Josef X Brunner
Centre Suisse d Electronique et de Microtechnique, Schulstrasse 1, 7302 Landquart, Switzerland
Intensive Care Med 35:1479-83. 2009..A recent hypothesis is that lung injury is caused by excessive stress and strain. This paper elaborates on that hypothesis and proposes a new approach to optimizing the breath pattern...
- Critique of the equivalent air altitude modelJohnny Conkin
Universities Space Research Association, 3600 Bay Area Boulevard, Houston, TX 77058 2769, USA
Aviat Space Environ Med 79:975-82. 2008..Adjustment through probabilistic statistical modeling to match the current limited experimental observations is one approach to a better isohypoxic model...
- Dead space: simplicity to complexityRobert A Klocke
J Appl Physiol 100:1-2. 2006
- Collateral gas transport by diffusion across tissue in the healthy, human lung; effects on dead spaceS C M Luijendijk
Department of Pulmonology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
Respir Physiol Neurobiol 133:99-107. 2002..The smallness of this effect means that the alveolar ventilation for Xe hardly benefits from this additional mechanism of intrapulmonary gas mixing...
- Dead space and paediatric anaesthetic equipment: a physical lung model studyD M Miller
Guy s, King s and St Thomas Hospitals School of Medicine, University of London, London, UK
Anaesthesia 59:600-6. 2004....
- The influence of physiotherapy and suction on respiratory deadspace in ventilated childrenEleanor Main
Centre for Nursing and Allied Health Professionals Research and Physiotherapy Department, Institute of Child Health, 7th Floor, Old Building, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WCIN 3JH, UK
Intensive Care Med 30:1152-9. 2004....
- Aspiration of dead space in the management of chronic obstructive pulmonary disease patients with respiratory failureYou ning Liu
Department of Respiratory Medicine, General Hospital of the Chinese People s Liberation Army, 28 Fuxing Road, Beijing 100853, China
Respir Care 49:257-62. 2004Carbon dioxide clearance can be improved by reducing respiratory dead space or by increasing the clearance of carbon-dioxide-laden expiratory gas from the dead space...
- Dynamic dead space in face masks used with noninvasive ventilators: a lung model studyE Saatci
Division of Engineering, King's College London, UK
Eur Respir J 23:129-35. 2004..5% of tidal volume. Exhaust ports over the nasal bridge in face masks effect important decreases in dynamic dead space provided positive pressure throughout the expiratory phase is used...
- The effect of diffusion in the respiratory tree on the alveolar amplitude response technique (AART)J P Whiteley
Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
Respir Physiol Neurobiol 137:81-96. 2003....
- Laboratory tests in the diagnosis of pulmonary embolismGuy Meyer
Service de Pneumologie, Hopital Europeen Georges Pompidou, Assistance Publique, Hopitaux de Paris, Universite Paris V, Paris, France
Respiration 70:125-32. 2003..Brain natriuretic peptide and cardiac troponin have limited usefulness for diagnosing PE, but both tests may identify patients with a poor prognosis, in whom more aggressive treatment may be warranted...
- Cardiorespiratory effects of added dead space in patients with heart failure and central sleep apneaRami N Khayat
University of Wisconsin, Department of Medicine and the Middleton Memorial Veterans Hospital, Madison 53705, USA
Chest 123:1551-60. 2003..8 +/- 0.4% vs 5.5 +/- 0.9%, respectively; p < 0.01). CONCLUSION: DS stabilized CSA and improved sleep quality in patients with CHF without significant acute adverse effects on the cardiovascular function...
- Steady-state end-tidal alveolar dead space measure and D-dimerFranck Verschuren
Chest 121:1373; author reply 1373-4. 2002
- [Respiratory deadspace and compliance measurements in neonates with congenital diaphragmatic hernia]R Romero
, Unidad de Cuidados Intensivos Neonatales, , C/Doctor Castelo, 49, 28009 Madrid
Cir Pediatr 15:57-62. 2002..Vd/Vt and DC measurement constitute a reliable method to predict outcome in patients with CDH...
- Deadspace ratioCharles Her
Crit Care Med 32:1441. 2004
- Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosisA G Thin
Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, Dublin Molecular Medicine Centre, University College, Earlsfort Terrace, Dublin, Ireland
Respir Med 98:1063-70. 2004..Exercise performance in CF might be enhanced by efforts directed at facilitating an increase in exercise tidal volume and therefore the adoption of a more efficient pattern of breathing...
- A visual aid for teaching ventilation-perfusion relationshipsJ M Norton
Department of Physiology and Pharmacology, University of New England College of Osteopathic Medicine, Biddeford, Maine 04005, USA
Adv Physiol Educ 24:38-42. 2000..This approach has greatly assisted some students in mastering this traditionally difficult area of respiratory physiology...
- Respiratory NeurobiologyGordon Mitchell; Fiscal Year: 2007..Thus, we propose to continue a training program that meets important goals of the NIH research-training mission. ..
- Pretest Probability Assessment for Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..In phase III, we will test the validity of the PE PREtest Consult TM and determine if the use of the PE PREtest ConsultTM will decrease unnecessary testing for PE. ..
- Surrogate markers for Severe Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2005..This study will determine if criteria that are widely and immediately available in most hospitals can be used to risk-stratify severity of PE and to clarify the role of nonmalignant thrombophilias on the prognosis of PE. ..
- Expired CO2/O2 Analysis to Diagnose Pulmonary EmbolismJEFFREY KLINE; Fiscal Year: 2007..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
- Mechanisms of respiratory long-term facilitationGORDON STEWART MITCHELL; Fiscal Year: 2010....
- PLASTICITY IN RESPIRATORY MOTOR CONTROLGordon Mitchell; Fiscal Year: 2004..A multidisciplinary approach will be used to test key elements of the model. ..
- Respiratory plasticity and spinal cord InjuryGordon Mitchell; Fiscal Year: 2007..Further, the conceptual advances promised from these studies may be applicable to other disorders of respiratory control, including neurodegenerative diseases such as ALS. ..
- Mechanisms of respiratory long-term facilitationGordon Mitchell; Fiscal Year: 2007....
- DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROLGordon Mitchell; Fiscal Year: 2001..Further understanding of mechanism(s) that underlie developmental plasticity with its associated functional impairments may provide the rationale for therapeutic intervention, thereby enhancing functional recovery. ..
- Secretory Phospholipase A2s in Airway PathophysiologyTeal S Hallstrand; Fiscal Year: 2010..Our goal is to determine the function of the sPLA2s in asthma so that novel therapies can be developed and tested in clinical trials that will improve the effectiveness of asthma treatments and alter the natural history of asthma. ..
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2007..abstract_text> ..
- Neuroendocrine regulation of erythropoiesis following traumaAlicia Mohr; Fiscal Year: 2007..This proposal is novel and understanding the neuroendocrine mechanism of erythropoiesis following trauma is a preliminary step towards potential therapeutic modalities for the treatment of anemia. ..
- WORKING MEMORY IN OBSTRUCTIVE SLEEP APNEA-AN fMRI STUDYRobert Thomas; Fiscal Year: 2006..abstract_text> ..
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2006..abstract_text> ..
- ECG-derived estimators of sleep physiologyRobert Thomas; Fiscal Year: 2006..3) To correlate the biomarker with excessive daytime sleepiness, subjective sleep quality and cardiovascular morbidity (SHHS), and reduced neurocognitive function (NAPS). ..
- COPD Clinical Research Network & Clinical Research Skills Core DevelopmentGerard Criner; Fiscal Year: 2007..abstract_text> ..