Summary: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).

Top Publications

  1. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
  2. pmc Astrocytes control breathing through pH-dependent release of ATP
    Alexander V Gourine
    Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    Science 329:571-5. 2010
  3. pmc The effect of respiration variations on independent component analysis results of resting state functional connectivity
    Rasmus M Birn
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1148, USA
    Hum Brain Mapp 29:740-50. 2008
  4. ncbi Respiration in the open ocean
    Paul A del Giorgio
    Department des Sciences Biologiques, Universite du Quebec a Montreal, CP 8888, Succ Centre Ville, Montreal, Quebec H3C 3P8, Canada
    Nature 420:379-84. 2002
  5. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
  6. ncbi The sniff as a unit of olfactory processing
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Chem Senses 31:167-79. 2006
  7. ncbi Physiology of diving of birds and mammals
    P J Butler
    School of Biological Sciences, The University of Birmingham, Edgbaston, United Kingdom
    Physiol Rev 77:837-99. 1997
  8. pmc Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration
    Thomas E Finger
    Department of Cellular and Structural Biology, Rocky Mountain Taste and Smell Center, Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:8981-6. 2003
  9. ncbi The use of active breathing control (ABC) to reduce margin for breathing motion
    J W Wong
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 44:911-9. 1999
  10. ncbi Effect of respiratory gating on quantifying PET images of lung cancer
    Sadek A Nehmeh
    Department of Medical Physics, Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 43:876-81. 2002

Detail Information

Publications324 found, 100 shown here

  1. ncbi The management of respiratory motion in radiation oncology report of AAPM Task Group 76
    Paul J Keall
    Virginia Commonwealth University, USA
    Med Phys 33:3874-900. 2006
    ..methods, respiratory gated techniques, breath-hold techniques, forced shallow-breathing methods, and respiration-synchronized techniques...
  2. pmc Astrocytes control breathing through pH-dependent release of ATP
    Alexander V Gourine
    Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    Science 329:571-5. 2010
    ..This demonstrates a potentially crucial role for brain glial cells in mediating a fundamental physiological reflex...
  3. pmc The effect of respiration variations on independent component analysis results of resting state functional connectivity
    Rasmus M Birn
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 1148, USA
    Hum Brain Mapp 29:740-50. 2008
    ..These slower respiration-induced signal changes occur at low frequencies and spatial locations similar to the fluctuations used to infer ..
  4. ncbi Respiration in the open ocean
    Paul A del Giorgio
    Department des Sciences Biologiques, Universite du Quebec a Montreal, CP 8888, Succ Centre Ville, Montreal, Quebec H3C 3P8, Canada
    Nature 420:379-84. 2002
    ..This will depend on the production of organic matter relative to the decomposition due to biological respiration. Estimates of respiration are available for the top layers, the mesopelagic layer, and the abyssal waters and ..
  5. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
    ..Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection...
  6. ncbi The sniff as a unit of olfactory processing
    Adam Kepecs
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Chem Senses 31:167-79. 2006
    ..studies-primarily from anesthetized rodents-demonstrating that olfactory neural responses are coupled to respiration. Hence, the "sniff cycle" might play a role in odor coding, by allowing the timing of spikes with ..
  7. ncbi Physiology of diving of birds and mammals
    P J Butler
    School of Biological Sciences, The University of Birmingham, Edgbaston, United Kingdom
    Physiol Rev 77:837-99. 1997
    ..Efferent cardiac control is largely parasympathetic. Reflex cardiorespiratory responses are modulated by conditioning and habituation, but reflexes predominate during extended dives and during recovery, when gas exchange is maximized...
  8. pmc Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration
    Thomas E Finger
    Department of Cellular and Structural Biology, Rocky Mountain Taste and Smell Center, Neuroscience Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:8981-6. 2003
    ..The trigeminal chemoreceptor cells are likely to be remnants of the phylogenetically ancient population of solitary chemoreceptor cells found in the epithelium of all anamniote aquatic vertebrates...
  9. ncbi The use of active breathing control (ABC) to reduce margin for breathing motion
    J W Wong
    Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073 6769, USA
    Int J Radiat Oncol Biol Phys 44:911-9. 1999
    ..Treatment planning and delivery can then be performed at identical ABC conditions with minimal margin for breathing motion...
  10. ncbi Effect of respiratory gating on quantifying PET images of lung cancer
    Sadek A Nehmeh
    Department of Medical Physics, Nuclear Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 43:876-81. 2002
    ..We have developed a new technique to gate lung 18F-FDG PET images in synchronization with the respiratory motion to reduce smearing due to breathing and improve quantitation of 18F-FDG uptake in lung lesions...
  11. ncbi Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?
    Fumihiko Yasuma
    Department of Internal Medicine, Suzuka National Hospital, 3 2 1 Kasado, Suzuka 513 8501, Japan
    Chest 125:683-90. 2004
    Respiratory sinus arrhythmia (RSA) is heart rate variability in synchrony with respiration, by which the R-R interval on an ECG is shortened during inspiration and prolonged during expiration...
  12. pmc Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study
    Karleyton C Evans
    Department of Psychiatry, Division of Neurotherapeutics, Massachusetts General Hospital East, 13th Street, Building 149, Suite 2625, Charlestown, MA 02129, USA
    Neuroimage 47:961-71. 2009
    ..We propose that the identified limbic/paralimbic-bulbar circuitry plays a significant role in cognitive and emotional modulation of spontaneous breathing...
  13. ncbi State-dependent modulation of breathing in urethane-anesthetized rats
    Silvia Pagliardini
    Department of Physiology, Centre for Neuroscience, and Women and Children s Health Research Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    J Neurosci 32:11259-70. 2012
  14. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
  15. ncbi Four-dimensional computed tomography: image formation and clinical protocol
    Eike Rietzel
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, Massachusetts 02114, USA
    Med Phys 32:874-89. 2005
    ..A protocol for 4DCT scanning was evaluated and clinically implemented at the MGH. Patient data are presented to elucidate how additional patient specific parameters can impact 4DCT imaging...
  16. pmc Sniffing behavior of mice during performance in odor-guided tasks
    Daniel W Wesson
    Department of Biology, Boston University, Boston, MA 02215, USA
    Chem Senses 33:581-96. 2008
    ..We found that respiration frequencies in quiescent mice ranged from 3 to 5 Hz--higher than that reported for rats...
  17. ncbi Transport of expiratory droplets in an aircraft cabin
    Jitendra K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment, School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    Indoor Air 21:3-11. 2011
    ..The total airborne droplet fraction reduced to 48, 32, 20, and 12% after they entered the cabin for 1, 2, 3, and 4 min, respectively, because of the ventilation from the environmental control system...
  18. ncbi Respiratory organ motion and dosimetric impact on breast and nodal irradiation
    X Sharon Qi
    Department of Radiation Oncology, University of Colorado Denver, Aurora, USA
    Int J Radiat Oncol Biol Phys 78:609-17. 2010
    ..To examine the respiratory motion for target and normal structures during whole breast and nodal irradiation and the resulting dosimetric impact...
  19. ncbi Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy
    Yvette Seppenwoolde
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 53:822-34. 2002
    ..Understanding the behavior of tumor motion in lung tissue to model tumor movement is necessary for accurate (gated or breath-hold) radiotherapy or CT scanning...
  20. pmc Respiratory response of the deep-sea amphipod Stephonyx biscayensis indicates bathymetric range limitation by temperature and hydrostatic pressure
    Alastair Brown
    University of Southampton, Ocean and Earth Science, National Oceanography Centre, Southampton, Southampton, United Kingdom
    PLoS ONE 6:e28562. 2011
    ..Subsequently, the effect of pressure on respiration rate is revealed to be dependent on temperature: pressure equivalent to 2000 m depth was tolerated at 1 and 3°..
  21. pmc Understanding the rhythm of breathing: so near, yet so far
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1763, USA
    Annu Rev Physiol 75:423-52. 2013
  22. ncbi Effects of exercise and respiration on blood flow in total cavopulmonary connection: a real-time magnetic resonance flow study
    V E Hjortdal
    Department of Cardiothoracic and Vascular Surgery, Skejby Hospital, Aarhus University Hospital, DK 8200 Aarhus N, Denmark
    Circulation 108:1227-31. 2003
    Little is known about blood flow and its relationship to respiration during exercise in patients with total cavopulmonary connection (TCPC).
  23. ncbi Hindbrain interneurons and axon guidance signaling critical for breathing
    Julien Bouvier
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 3294, Gif sur Yvette, France
    Nat Neurosci 13:1066-74. 2010
  24. ncbi Inspiratory muscle training improves maximal inspiratory pressure and may assist weaning in older intubated patients: a randomised trial
    Samária Ali Cader
    University Federal do Estada do Rio de Janiero LABIMH UNIRIO, Brazil
    J Physiother 56:171-7. 2010
    ..Does inspiratory muscle training improve maximal inspiratory pressure in intubated older people? Does it improve breathing pattern and time to wean from mechanical ventilation?..
  25. ncbi Choice of nasal nitric oxide technique as first-line test for primary ciliary dyskinesia
    J K Marthin
    Danish PCD Center, Paediatric Pulmonary Service, 5003, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur Respir J 37:559-65. 2011
    ..nNO is a helpful first-line tool in real-life PCD work-up in all age groups if the sampling method is chosen according to age. nNO can be misleading in a few patients with true PCD. Further studies are strongly needed in young children...
  26. ncbi Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics
    N T Tgavalekos
    Department of Anesthesia and Critical Care CLN 237F, Massachusetts General Hospital, and Department of Biomedical Engineering, Boston University, Boston 02114, USA
    Eur Respir J 29:1174-81. 2007
    ..The current data supports the concept that patchy ventilation is an expression of the integrated system and not just the sum of independent responses of individual airways...
  27. ncbi Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques
    Valentino Bettinardi
    Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy
    Radiother Oncol 96:311-6. 2010
    ..To describe the degradation effects produced by respiratory organ and lesion motion on PET/CT images and to define the role of respiratory gated (RG) 4D-PET/CT techniques to compensate for such effects...
  28. ncbi Phosphine resistance, respiration rate and fitness consequences in stored-product insects
    Marco Aurélio G Pimentel
    Departamento de Biologia Animal, Universidade Federal de Vicosa, Vicosa, MG 36570 000, Brazil
    Pest Manag Sci 63:876-81. 2007
    ..In all three species there was significant association (P < 0.05) between respiration rate and phosphine resistance...
  29. ncbi Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases
    Stephan W Schwarzacher
    Institute of Clinical Neuroanatomy, Neuroscience Center, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Brain 134:24-35. 2011
  30. pmc Central cholinergic regulation of respiration: nicotinic receptors
    Xuesi M Shao
    Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1763, USA
    Acta Pharmacol Sin 30:761-70. 2009
    ..These receptors mediate central cholinergic regulation of respiration and effects of the exogenous ligand nicotine on respiratory pattern...
  31. pmc Determination of comprehensive arterial blood inflow in abdominal-pelvic organs: impact of respiration and posture on organ perfusion
    Takuya Osada
    Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo, Japan
    Med Sci Monit 17:CR57-66. 2011
    ..However, little information exists regarding the influence of respiration (interplay between inspiration and expiration) and posture on BFAP.
  32. pmc Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants
    Philipp Latzin
    Division of Respiratory Medicine, Department of Paediatrics, Inselspital and University of Bern, Bern, Switzerland
    PLoS ONE 4:e4635. 2009
    ..Although some studies have shown lower lung volumes and increased ventilation inhomogeneity in BPD infants, conflicting results exist possibly due to differences in sedation and measurement techniques...
  33. pmc Symbolic dynamic analysis of relations between cardiac and breathing cycles in patients on weaning trials
    P Caminal
    Departament ESAII, Universitat Politecnica de Catalunya UPC, Pau Gargallo, 5, 08028 Barcelona, Spain
    Ann Biomed Eng 38:2542-52. 2010
  34. pmc Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity
    Robert T R Huckstepp
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    J Physiol 588:3901-20. 2010
    ..We therefore propose that Cx26-mediated release of ATP in response to changes in PCO2 is an important mechanism contributing to central respiratory chemosensitivity...
  35. ncbi Nasal contribution to breathing with exercise: effect of race and gender
    William D Bennett
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Appl Physiol (1985) 95:497-503. 2003
    ..Men also had a lesser nasal contribution to breathing during exercise compared with women. This is likely due to greater minute ventilations at any given percentage of maximum workload in men vs. women...
  36. ncbi Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
    Veronique Dubreuil
    Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:14836-46. 2009
    ..Together, our results provide genetic evidence for the essential role of the Phox2b-expressing RTN neurons both in establishing a normal respiratory rhythm before birth and in providing chemosensory drive...
  37. ncbi Neurokinin-1 receptor-expressing cells of the ventral respiratory group are functionally heterogeneous and predominantly glutamatergic
    Patrice G Guyenet
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 22:3806-16. 2002
    ..In summary, NK1R-expressing cells of the VRG are a heterogeneous group of predominantly glutamatergic neurons that include subpopulations of respiratory premotor neurons...
  38. pmc The respiration response function: the temporal dynamics of fMRI signal fluctuations related to changes in respiration
    Rasmus M Birn
    Laboratory of Brain and Cognition, National Institute of Mental Health, 10 Center Dr, Bldg 10, Rm 1D80, Bethesda, MD 20892 1148, USA
    Neuroimage 40:644-54. 2008
    ..b>Respiration related signal changes appear to be slower than neuronally induced BOLD signal changes and are not modeled ..
  39. ncbi Augmented responses to ozone in obese carboxypeptidase E-deficient mice
    Richard A Johnston
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115 6021, USA
    Am J Physiol Regul Integr Comp Physiol 290:R126-33. 2006
    ..These results also suggest that chronic systemic inflammation may enhance airway responses to O3 in obese mice...
  40. ncbi Information domain analysis of cardiovascular variability signals: evaluation of regularity, synchronisation and co-ordination
    A Porta
    Dipartimento di Scienze Precliniche, Universita degli Studi di Milano, Italy
    Med Biol Eng Comput 38:180-8. 2000
    ..during sympathetic activation induced by head-up tilt (T), during the perturbing action produced by controlled respiration at 10, 15 and 20 breaths/min (CR10, CR15 and CR20), and after peripheral muscarinic blockade provoked by the ..
  41. ncbi 4-dimensional computed tomography imaging and treatment planning
    Paul Keall
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond 23298 0058, USA
    Semin Radiat Oncol 14:81-90. 2004
    ..This article discusses methodology for 4D CT imaging and 4D treatment planning, with some comments on 4D radiation delivery...
  42. ncbi Brain, breathing and breathlessness
    A Guz
    Charing Cross and Westminster Medical School, London, UK
    Respir Physiol 109:197-204. 1997
    ..The opportunities for further work are outlined...
  43. ncbi Sleep apnea and effect of chemostimulation on breathing instability in mice
    Akira Nakamura
    Department of Autonomic Physiology, Graduate School of Medicine, Chiba University, Chiba City, Japan
    J Appl Physiol 94:525-32. 2003
    ..Our data indicated that significant sleep apnea occurs in normal adult mice and suggested that the mouse could be a promising experimental model with which to study the genetic and molecular basis of respiratory regulation during sleep...
  44. ncbi Continuous non-invasive blood pressure monitoring using concentrically interlocking control loops
    J Fortin
    Institute of Medical Engineering, Graz, University of Technology, Krenngasse, Graz, Austria
    Comput Biol Med 36:941-57. 2006
    ..Examples of long-term BP recordings at rest and during autonomic function tests illustrate the potential of the new instrument...
  45. ncbi Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity
    L Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    J Hypertens 19:2221-9. 2001
    ..To investigate whether breathing more slowly modifies the sensitivity of the chemoreflex and baroreflex...
  46. ncbi Running, breathing and visceral motion in the domestic rabbit (Oryctolagus cuniculus): testing visceral displacement hypotheses
    R S Simons
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 202:563-77. 1999
  47. ncbi Validation of the Adult OMNI Scale of perceived exertion for walking/running exercise
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Med Sci Sports Exerc 36:1776-80. 2004
    ..Concurrent and construct validity of the OMNI-Walk/Run Scale of Perceived Exertion was examined using young adult women and men (18-36 yr)...
  48. pmc Peripheral mechanisms for vocal production in birds - differences and similarities to human speech and singing
    Tobias Riede
    Department of Biology and National Center for Voice and Speech, University of Utah, Salt Lake City, 84112, USA
    Brain Lang 115:69-80. 2010
    ..As in humans, bird phonation involves three main motor systems (respiration, vocal organ and vocal tract)...
  49. pmc Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
    Sergio Rey
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, P Universidad Católica of Chile, Santiago, Chile
    J Physiol 560:577-86. 2004
    ..Thus, the enhanced CB reactivity to hypoxia may contribute to the augmented ventilatory response to hypoxia, as well as to modified heart rate variability due to early changes in autonomic activity...
  50. ncbi Effect of heliox breathing on dynamic hyperinflation in COPD patients
    Matteo Pecchiari
    Istituto di Fisiologia Umana I, Universita di Milano, Milan, Italy
    Chest 125:2075-82. 2004
    ..Helium-oxygen mixtures (ie, heliox) have been used in treating these patients on the assumption that, by lowering airway resistance, they might be beneficial...
  51. pmc Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition
    Russell S Ray
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 333:637-42. 2011
    ..of the ligand clozapine-N-oxide (CNO) by systemic injection attenuated the chemoreflex that normally increases respiration in response to tissue carbon dioxide (CO(2)) elevation and acidosis...
  52. ncbi Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS
    Raghunathan Sridhar
    Division of Newborn Medicine, Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA
    Pediatr Pulmonol 36:113-22. 2003
    ..Some SIDS infants appear to be different from infants dying with other diagnoses with respect to efficacy and characteristics of hypoxic gasping...
  53. pmc Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats
    Stephen B G Abbott
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 29:5806-19. 2009
    ..These results provide strong evidence that the Phox2b-expressing noncatecholaminergic neurons of the RTN region function as central respiratory chemoreceptors...
  54. ncbi Respiratory patterns and oxygen consumption in singing zebra finches
    Michele Franz
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Biol 206:967-78. 2003
    ..We investigated the effect of the song motor pattern on respiration using a newly developed mask system to measure oxygen consumption while simultaneously monitoring subsyringeal ..
  55. ncbi Respiratory variations in pulse oximetry plethysmographic waveform amplitude to predict fluid responsiveness in the operating room
    Maxime Cannesson
    Hospices Civils de Lyon, Department of Anesthesiology and Intensive Care, Louis Pradel Hospital, Claude Bernard Lyon I University, France
    Anesthesiology 106:1105-11. 2007
    ..The authors hypothesized that DeltaPOP can predict fluid responsiveness in mechanically ventilated patients during general anesthesia...
  56. ncbi St. George's Respiratory Questionnaire: MCID
    Paul W Jones
    St George s Hospital Medical School, London, UK
    COPD 2:75-9. 2005
  57. ncbi Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons
    Matthew R Hodges
    Department of Neurology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 28:2495-505. 2008
    ..We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense...
  58. ncbi Free-breathing whole-heart coronary MRA with 3D radial SSFP and self-navigated image reconstruction
    C Stehning
    Institute of Biomedical Engineering, Karlsruhe, Germany
    Magn Reson Med 54:476-80. 2005
    ..A signal synchronous with respiration was extracted directly from the echoes acquired for imaging, and the motion information was used for ..
  59. ncbi A novel functional neuron group for respiratory rhythm generation in the ventral medulla
    Hiroshi Onimaru
    Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Neurosci 23:1478-86. 2003
    ..Our findings suggest that the pFRG comprises a neuronal population that is involved in the primary respiratory rhythm generation in the rostrocaudally extending respiratory neuron network of the medulla...
  60. ncbi Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients
    Nico J Diederich
    Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg
    Mov Disord 20:1413-8. 2005
    In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG)...
  61. ncbi Neural correlates of voluntary breathing in humans
    L C McKay
    National Heart and Lung Instiute, Imperial College London, London W6 8RP, United Kingdom
    J Appl Physiol 95:1170-8. 2003
    ..012). Activity within the medulla suggests that the brain stem respiratory centers may have a role in mediating the voluntary control of breathing in humans...
  62. ncbi Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  63. ncbi Slow breathing increases arterial baroreflex sensitivity in patients with chronic heart failure
    Luciano Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    Circulation 105:143-5. 2002
    ..It is well established that a depressed baroreflex sensitivity may adversely influence the prognosis in patients with chronic heart failure (CHF) and in those with previous myocardial infarction...
  64. ncbi Short-term variability of respiration and sleep during unattended nonlaboratory polysomnography--the Sleep Heart Health Study. [corrected]
    Stuart F Quan
    Arizona Respiratory Center and Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Sleep 25:843-9. 2002
    To determine the short-term variability of indices of disturbed respiration and sleep during 2 nights of unattended nonlaboratory polysomnography conducted several months apart.
  65. pmc Temporal structure of receptor neuron input to the olfactory bulb imaged in behaving rats
    Ryan M Carey
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Neurophysiol 101:1073-88. 2009
    ..input from olfactory receptor neurons (ORNs) are poorly characterized and depend on multiple factors, including respiration-driven airflow through the nasal cavity, odorant sorption kinetics, receptor-ligand interactions between ..
  66. ncbi Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease
    Thomas Haider
    Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria
    J Hypertens 27:1648-54. 2009
    ..This study evaluates the effects of interval hypoxic training on cardiovascular and respiratory control in patients with mild COPD...
  67. ncbi Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation
    Philip N Ainslie
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Regul Integr Comp Physiol 296:R1473-95. 2009
    ..Finally, we describe the use of a newly developed steady-state modeling approach to examine the effects of changes in CBF on the chemoreflex control of breathing and suggest avenues for future research...
  68. pmc Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage
    Benjamin Gauter-Fleckenstein
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 48:1034-43. 2010
    ..The radioprotective effects are presumably mediated through its ability both to suppress oxidative stress and to decrease activation of key transcription factors and proangiogenic and profibrogenic cytokines...
  69. pmc Technical note: Correlation of respiratory motion between external patient surface and internal anatomical landmarks
    Hadi Fayad
    INSERM U650, LATIM, CHU Morvan, Brest F 29200, France
    Med Phys 38:3157-64. 2011
    ..The main objective of this study was to assess the motion correlation between such an external patient surface and internal anatomical landmarks motion...
  70. ncbi RapidArc combined with the active breathing coordinator provides an effective and accurate approach for the radiotherapy of hepatocellular carcinoma
    G Z Gong
    Department of Radiation Oncology, Shandong Cancer Hospital, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Academy of Medical Sciences, 440 Jiyan Road, 250117, Jinan, China
    Strahlenther Onkol 188:262-8. 2012
  71. ncbi Survey of stereotactic body radiation therapy in Japan by the Japan 3-D Conformal External Beam Radiotherapy Group
    Yasushi Nagata
    Division of Radiation Oncology, Hiroshima University Hospital, Hiroshima, Japan
    Int J Radiat Oncol Biol Phys 75:343-7. 2009
    ..To recognize the current status of stereotactic body radiotherapy (SBRT) in Japan, using a nationwide survey conducted by the Japan 3-D Conformal External Beam Radiotherapy Group...
  72. ncbi Modeling the ponto-medullary respiratory network
    I A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Respir Physiol Neurobiol 143:307-19. 2004
    ..The model and experimental data described support the concept that during eupnea the respiration-related pontine structures control the medullary network mechanisms for respiratory phase transitions, suppress ..
  73. ncbi Spinal and pontine relay pathways mediating respiratory rhythm entrainment by limb proprioceptive inputs in the neonatal rat
    Aurore Giraudin
    Unité Mixte de Recherche 5287, Institut de Neurosciences Cognitives et Intégratives d Aquitaine, Centre National de la Recherche Scientifique, Universite Bordeaux, F 33000 Bordeaux, France
    J Neurosci 32:11841-53. 2012
    The coordination of locomotion and respiration is widespread among mammals, although the underlying neural mechanisms are still only partially understood...
  74. pmc Irregular Breathing in Mice following Genetic Ablation of V2a Neurons
    Steven A Crone
    Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 32:7895-906. 2012
    ..Thus, neurons of the embryonic V2a lineage appear to have been recruited to neural networks that control breathing and locomotion, two prominent CPG-driven, repetitive motor behaviors...
  75. pmc Stable small animal ventilation for dynamic lung imaging to support computational fluid dynamics models
    Richard E Jacob
    Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 6:e27577. 2011
    ..In addition, continuous monitoring of breath-to-breath pressure and volume waveforms and long-term trends in PIP and flow provide diagnostics of changes in breathing mechanics...
  76. ncbi Clinical validation of a 4D-CT based method for lung ventilation measurement in phantoms and patients
    Tine B Nyeng
    Departments of Medical Physics and Oncology, Aarhus University Hospital Aarhus University, Aarhus, Denmark
    Acta Oncol 50:897-907. 2011
    ..The method calculates the displacement vector fields (DVFs) resulting from the DIR using the Jacobian map approach in order to extract information regarding regional lung volume change...
  77. ncbi Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results
    Luc Boucher
    Metabolic and Functional Imaging Center, Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke Hôpital Fleurimont, 3001 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    J Nucl Med 45:214-9. 2004
    ..This study was undertaken to assess the feasibility of respiratory gating for PET of the chest and the impact of respiratory motion on quantitative analysis...
  78. ncbi Effect of tidal volume on distribution of ventilation assessed by synchrotron radiation CT in rabbit
    L Porra
    Department of Physical Sciences, University of Helsinki, Helsinki FIN 00014, Finland
    J Appl Physiol (1985) 96:1899-908. 2004
    A respiration-gated synchrotron radiation computed tomography (SRCT) technique, which allows visualization and direct quantification of inhaled stable xenon gas, was used to study the effect of tidal volume (Vt) on regional lung ..
  79. ncbi A simple respiratory indicator for irradiation during voluntary breath holding: a one-touch device without electronic materials
    Hiroshi Onishi
    Department of Radiation Oncology, Yamanashi University, 1110 Shimokato, Chuo City, Yamanashi, Japan
    Radiology 255:917-23. 2010
    ..To evaluate the use, structural principles, operation, and acquired reproducibility of a respiratory monitoring device to be used for voluntary patient breath holding...
  80. ncbi Topographical specificity of regulation of respiratory and renal sympathetic activity by the midbrain dorsolateral periaqueductal gray
    Kamon Iigaya
    Department of Physiology, The University of Sydney, Australia
    Am J Physiol Regul Integr Comp Physiol 299:R853-61. 2010
    ..914, P < 0.001), suggesting the possibility that a common population of "command neurons" within the dorsolateral PAG may generate both sympathetic and respiratory responses from this region...
  81. ncbi Morphology of sighs and their role in the control of breathing in preterm infants, term infants and adults
    M Qureshi
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man R3E 0L8, Canada
    Neonatology 96:43-9. 2009
    ..Although there is evidence that sighs are important to restore lung volume, the factors responsible for inducing a sigh and the effects of sighs on the stability of the respiratory system remain unclear...
  82. pmc The valsalva maneuver revisited: the influence of voluntary breathing on isometric muscle strength
    Elizabeth R Ikeda
    Motor Control Laboratory, School of Physical Therapy and Rehabilitation Science, University of Montana, Missoula, Montana, USA
    J Strength Cond Res 23:127-32. 2009
    ..Given the increased cardiovascular risks associated with the Valsalva maneuver, it is highly recommended that forced exhalation be used during exercise at maximal levels, especially in repetitive repetitions...
  83. ncbi Deviations in delineated GTV caused by artefacts in 4DCT
    Gitte Fredberg Persson
    Department of Radiation Oncology, Rigshospitalet, Copenhagen, Denmark
    Radiother Oncol 96:61-6. 2010
    ..Irregular breathing, large tumour motion or interpolation of images can cause artefacts in the 4DCT. This study evaluates the impact of artefacts on gross tumour volume (GTV) size...
  84. ncbi Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer
    H Helen Liu
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 68:531-40. 2007
    To assess three-dimensional tumor motion caused by respiration and internal target volume (ITV) for radiotherapy of lung cancer.
  85. ncbi Predicting respiratory motion for four-dimensional radiotherapy
    S S Vedam
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Med Phys 31:2274-83. 2004
    ..motion is made possible through corrective action based on real-time feedback of target position during respiration. The advantage of this approach lies with its ability to allow tighter margins around the target while ..
  86. ncbi Effect of respiration, talking and small body movements on blood pressure measurement
    D Zheng
    Cardiovascular Physics and Engineering Research Group, Regional Medical Physics Department, Newcastle University, Freeman Hospital, Newcastle upon Tyne, UK
    J Hum Hypertens 26:458-62. 2012
    ..05, except for DBP while talking). We have shown that measurement conditions significantly influence manual auscultatory BPs and their measurement variabilities, and we provide quantitative data to allow comparison of the effects...
  87. ncbi Deep-inspiration breath-hold PET/CT versus free breathing PET/CT and respiratory gating PET for reference: evaluation in 95 patients with lung cancer
    Tsuyoshi Kawano
    Division of Nuclear Medicine, Kanagawa Cancer Center, Nakao 1 1 2, Asahi ku, Yokohama 241 0815, Japan
    Ann Nucl Med 25:109-16. 2011
  88. ncbi The role of the subelytral cavity in respiration in a tenebrionid beetle, Onymacris multistriata (Tenebrionidae: Adesmiini)
    F D Duncan
    School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, 2193 Parktown, South Africa
    J Insect Physiol 49:339-46. 2003
    ..Thus the subelytral cavity plays a different role in respiration other than the elimination of CO(2) build-up...
  89. ncbi Quantifying interfraction and intrafraction tumor motion in lung stereotactic body radiotherapy using respiration-correlated cone beam computed tomography
    Jean Pierre Bissonnette
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 75:688-95. 2009
    ..However, the precise extent of these changes in breathing pattern is not well known. We evaluated the inter- and intrafractional changes in tumor motion amplitude (DeltaM) over an SBRT course...
  90. ncbi Nasal airway measurements in children treated by rapid maxillary expansion
    Giacomo Ceroni Compadretti
    Department of Otorhinolaryngology, Imola Hospital, Imola, Italy
    Am J Rhinol 20:385-93. 2006
    ..The availability of a reliable and objective technique to assess the geometry of nasal cavities, such as acoustic rhinometry, stimulated the present investigation...
  91. ncbi HPA axis, respiration and the airways in stress--a review in search of intersections
    James L Abelson
    Stress and Anxiety Research Group, Department of Psychiatry Trauma, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Psychol 84:57-65. 2010
    ..We examine HPA hormone effects on respiration, immune/inflammatory mediators, and lung maturation. We also examine respiratory/dyspnea effects on HPA axis...
  92. ncbi Tracheal occlusions evoke respiratory load compensation and neural activation in anesthetized rats
    Kathryn M Pate
    Physiological Sciences, University of Florida, Gainesville, Florida 32603, USA
    J Appl Physiol (1985) 112:435-42. 2012
  93. ncbi Respiratory sinus arrhythmia in conscious humans during spontaneous respiration
    P D Larsen
    Department of Surgery and Anaesthesia, University of Otago, Wellington, Wellington South, New Zealand
    Respir Physiol Neurobiol 174:111-8. 2010
  94. ncbi Neuronal pacemaker for breathing visualized in vitro
    N Koshiya
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 400:360-3. 1999
    ..These results provide evidence that the neuronal kernel for rhythm generation consists of a network of synaptically-coupled pacemaker neurons...
  95. ncbi Interfraction and respiratory organ motion during conformal radiotherapy in gastric cancer
    Barbara Wysocka
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 77:53-9. 2010
    ..To quantify the interfraction and breathing organ motion during adjuvant radiotherapy for gastric cancer and assess organ stability in different breathing states...
  96. pmc Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression
    Shilpa Iyer
    Center for the Study of Neurodegenerative Diseases and The Morris K Udall Parkinson s Disease Research Center of Excellence, University of Virginia, PO Box 800394, Charlottesville, VA 22908, United States
    Mitochondrion 9:196-203. 2009
    ..MTD-TFAM reversibly increased respiration and levels of respiratory proteins...
  97. ncbi Electrophysiologic evaluation of Sudarshan Kriya: an EEG, BAER, P300 study
    M Bhatia
    Department of Neurology, All India Institute of Medical Sciences, New Delhi
    Indian J Physiol Pharmacol 47:157-63. 2003
    ..To compare the resting Electroencephalogram (EEG), Brainstem Auditory Evoked Responses (BAER) and P300 amongst trained and regular practitioners of Sudarshan Kriya (SK) GP-I and Controls (GP-II)...
  98. ncbi Single breath-hold assessment of ventricular volumes using 32-channel coil technology and an extracellular contrast agent
    Victoria Parish
    Division of Imaging Sciences, NIHR Biomedical Research Centre at Guy s and St Thomas NHS Foundation Trust, King s College London, London, UK
    J Magn Reson Imaging 31:838-44. 2010
    ..To evaluate the feasibility of a single breath-hold 3D cine balanced steady-state free precession (b-SSFP) sequence after gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) injection for volumetric cardiac assessment...
  99. ncbi Four-dimensional measurement of the displacement of internal fiducial markers during 320-multislice computed tomography scanning of thoracic esophageal cancer
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 79:588-95. 2011
    ..To investigate the three-dimensional movement of internal fiducial markers placed near esophageal cancers using 320-multislice CT...
  100. ncbi The sniff is part of the olfactory percept
    Joel Mainland
    Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, Berkeley, CA 94720, USA
    Chem Senses 31:181-96. 2006
  101. ncbi Nonlinear measures of respiration: respiratory irregularity and increased chaos of respiration in patients with panic disorder
    Vikram Kumar Yeragani
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich, USA
    Neuropsychobiology 46:111-20. 2002
    ..In this study, we used these measures of respiration to compare normal controls (n = 18) and patients with panic disorder (n = 22) in addition to the traditional ..

Research Grants75

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..To address this problem, we will employ in vitro isolated heart and in vivo mitochondrial respiration studies in conjunction with the newly emerging iTRAQ 8plex proteomics approach, LC MS/MS and PANTHER ..
  3. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Electron microscopy will be used to detect alterations in mitochondrial ultrastructure. Mitochondrial respiration will be measured by polarography and the defective component in the oxidative phosphorylation pathway will be ..
  4. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..NO* binds to cytochrome oxidase, resulting in superoxide (*O2-) and ONO2- which inhibits mitochondrial respiration. This leads to swelling and rupture of the mitochondria, cytochrome c release and apoptosis...
  5. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012 a posttranslational modification, transcriptional regulation of differentiation, growth hormones, respiration, cell cycle, cell death, spermatogenesis, obesity, stress, immunology, eye development, and dinosaur ..
  6. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..and Akt expression and evoked two vital responses to promote survival: 1) Increase in mitochondrial density and respiration rate. 2) Increase in smooth muscle cell Ca++ uptake...
  7. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    ..NO which at low concentrations inactivates the hemoprotein cytochrome c oxidase to regulate mitochondrial respiration and cellular function...
  8. Metabolic mechanisms of antiestrogen resistance in breast cancer
    ..cancer cells with high OXPHOS metabolism via upregulation of monocarboxylate transporter 1 (MCT1), nuclear respiration factor 1 (NRF1) and mitoNEET and stromal cells with low OXPHOS metabolism and high catabolism via upregulation ..
  9. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..The traditional approach to quantifying sleep and sleep-respiration relies on manual or computer assisted scoring of 30 second epochs, tagging of discrete fast phasic ..
  10. Arsenic Trioxide and Acute Myeloid Leukemia
    Yongkui Jing; Fiscal Year: 2012
    ..Under physiological conditions ROS generated as a byproduct of mitochondrial respiration are detoxified by glutathione-enzymes, glutathione peroxidase (GPx), glutathione-s-transferase ? (GST?) and ..
  11. Genetic Studies of Optic Atrophy
    Taosheng Huang; Fiscal Year: 2012
    ..We will examine superoxide dismutase (SOD) activity and mitochondrial respiration rate in our dOpa1 flies. Finally, we will test if antioxidants can rescue the shortened lifespan phenotype...
  12. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..This aim will address if the chaperone-dependent effects of HSPs directly affects mitochondrial respiration and energy production...
  13. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..Impaired fusion alters mitochondrial membrane potential, impairs respiration and promotes SMC proliferation...
  14. Mitochondrial Dysfunction and Adipose Insulin Resistance
    DAVID BERNLOHR; Fiscal Year: 2009
    ..Carbonylation of mitochondrial protein results in decreased TCA cycle activity, defective State 3 respiration and increased superoxide anion production...
  15. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..I will characterize the resulting biological consequences, such as altered mitochondrial respiration or metabolism, and begin investigation of the molecular mechanism(s) underlying those changes that are mediated ..
    John S Olson; Fiscal Year: 2010
    ..this NO scavenging reaction protects striated muscle and other aerobic tissues from inhibition of mitochondrial respiration during inflammation, sepsis, and nitric oxide inhalation...
  17. Respiration in Sepsis
    Claude A Piantadosi; Fiscal Year: 2013
    ..Understanding these fundamental regulatory mechanisms is needed to design forward-thinking therapeutic approaches to protect mitochondrial quality control during sepsis. ..
  18. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..with sleep disordered breathing that we hypothesize results from the loss of neurons in brain areas controlling respiration. If breathing is to be understood in normal and in pathological conditions, the site(s) and mechanisms for ..
  19. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..glycine receptors, which are important in functions such as convulsions, sensory integration, muscle tone and respiration. Therefore, these results may contribute to the development of new treatments for alcoholism...
  20. Mitochondrial Mechanisms of Programmed Necrosis in the Aged Female Heart
    Alexandra M Machikas; Fiscal Year: 2013
    ..As such, cell fate relies heavily on ATP production via mitochondrial respiration (MR) and ROS production...
  21. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..In association with low NO, the cells have reduced mitochondria numbers &respiration, which is accompanied by ~3-fold increase in glycolysis for energy production...
  22. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..and rate-limiting enzyme of the pentose phosphate pathway, is reversibly linked to glycolysis and mitochondrial respiration, and is the principal cytosolic source of NADPH, a reducing equivalent that is required to maintain redox ..
  23. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013 primordial follicles is exposed to low levels of reactive oxygen species (ROS) produced by mitochondrial respiration over decades...
  24. FASEB SRC on Mitochondrial Assembly &Dynamics in Health, Disease &Aging
    Antoni Barrientos; Fiscal Year: 2011 promote the exchange of scientific ideas among scientists interested in diverse aspects of mitochondrial respiration and biogenesis of the respiratory complexes...
    Elton T Young; Fiscal Year: 2013
    ..Their glycolytic pathway is so efficient that they can dispense altogether with respiration, making them a so-called "petite-negative" yeast, meaning they can grow without a functioning mitochondrial ..
  26. Mitochondrial function and antifungal photodynamic therapy
    Constantine G Haidaris; Fiscal Year: 2011
    ..Our long-range goal is to develop a two-step therapeutic strategy by which fungal respiration is first selectively inhibited, resulting in an increased susceptibility to oxidative stress induced by PDT ..
  27. Mechanisms and metabolic implications of LRP130 in NAFLD
    Marcus P Cooper; Fiscal Year: 2013
    ..Notably, LRP130 profoundly influences respiratory chain formation, respiration and superoxide formation...
  28. Analysis of the tumor suppressor gene Tsc1 in motor neuron patterning
    Onanong Chivatakarn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Motor neurons (MNs) enable control over locomotion, respiration and autonomic responses, and are profoundly affected by diseases such as spinal muscle atrophy (SMA) and amyotrophic lateral sclerosis (..
  29. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..between the two genomes is disrupted, leading to loss of electron transport chain (ETC) stoichiometry, reduced respiration and ATP, increased reactive oxygen species (ROS) and lactate, and a failure of muscle mitochondria to adapt ..
  30. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    ..Outcome variables and related measures include: Breathing (spirometry, pulse oximetry, dyspnea, respiration rate, 6-Minute Walk test);oxygenation (pulse oximetry;heart rate);stress (Perceived Stress Scale;diurnal ..
  31. Perinatal Programming of Infant Stress Reactivity and the Atopic Phenotype
    Rosalind J Wright; Fiscal Year: 2013
    ..psychological functioning, and postnatal caregiving behaviors impact the infant stress response (cortisol, respiration, sympathetic and parasympathetic autonomic functioning), assessed during a standardized laboratory protocol at ..
  32. Structure and function of stress fibers and cell adhesion sites
    Mary C Beckerle; Fiscal Year: 2013
    ..Normal physiological functions associated with respiration, circulation, locomotion, and digestion expose cells to mechanical stress that can deform or damage ..
  33. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..the following aims: Specific Aim I: To determine the role and mechanism(s) of HO/CO in the regulation of respiration to protect against organ dysfunction from hemorrhagic shock. Specific Aim II...
  34. Mitoenergetic Failure in Brain Aging
    Gregory J Brewer; Fiscal Year: 2013
    ..rat neurons in culture promote normal neuron survival, normal regeneration, normal glucose uptake and normal respiration, but do so with decrepit mitochondria which fail to upregulate energy production under stress...
  35. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..In addition to our battery of existing measurements of respiration, heart rate, blood pressure, movement, EEG and temperature, we propose to incorporate new state of the art ..
  36. Protein Kinase C in the Repair of Cellular Functions
    Grazyna Nowak; Fiscal Year: 2013
    ..Specific Aim 3 will determine whether PKC-??and/or PKC-??regulate mitochondrial respiration and ATP production in ischemic kidney and whether protein complexes involved in oxidative phosphorylation are ..
  37. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..H2S attenuates leukocyte adhesion, modulates mitochondrial respiration, and inhibits both apoptosis, and oxidative stress...
    J Kevin Foskett; Fiscal Year: 2013
    ..of an essential requirement of InsP3R activity to suppress macroautophagy and maintain efficient mitochondrial respiration and normal cell bioenergetics...
  39. Seahorse XF96 Extracellular Flux Analyzer
    Enrique Saez; Fiscal Year: 2013
    ..Flux Analyzer uses a simple microplate format to simultaneously measure oxygen consumption (cellular respiration) and extracellular acidification rates, in real time...
  40. Targeting Mitotic Kinases Inhibitors for Cancer Therapy
    E Premkumar Reddy; Fiscal Year: 2013
    ..targeted ablation of SCO2 gene in HCT116 human colon cancer cell line results in the ablation of mitochondrial respiration and that PLK2 is the most highly expressed gene in SCO2-/-cells...
  41. Mechanisms and Therapeutics for Rett Syndrome
    Mriganka Sur; Fiscal Year: 2013
    ..of the animals along metrics of maturation in central control systems, including locomotion, heart rate, respiration, and survival rates...
  42. Redox Regulation of Kv Channels
    SRINIVAS TIPPARAJU; Fiscal Year: 2013
    ..Because the ratio of reduced and oxidized nucleotides is tightly controlled by glycolysis and mitochondrial respiration, we suggest that differential regulation of Kv1-2 currents by pyridine nucleotides is a physiological mechanism ..
  43. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013
    ..e., the uncoupling of energy production from respiration in the mitochondria...
  44. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..The NTS is involved in the regulation of feeding, respiration, processing of interoceptive information, and was recently implicated in opiate reward, yet its role in ..
  45. Ca2+ mishandling and ischemia-vulnerability in fALS model motor terminals
    Gavriel David; Fiscal Year: 2012
    ..We hypothesize that mitochondria of fALS mouse terminals eventually lose their capacity to increase respiration sufficiently to sequester the Ca2+ overload associated with these stresses, resulting in mitochondrial ..
  46. The Role of PGC-1aplha in the Pathogenesis of Myotonic Dystrophy Type 1
    Xiang Fang; Fiscal Year: 2013
    ..type 1 (DM1) are characterized by progressive muscle weakness and wasting, impaired mitochondrial (Mt) respiration, hyperglycemia and insulin resistance, diminished metabolic capacity and elevated oxidative stress...
  47. Role of Autophagy in Cancer
    Eileen White; Fiscal Year: 2013
    ..have high levels of basal autophagy and are extremely dependent on autophagy for sustaining mitochondrial respiration, for survival in stress and for tumorigenesis...
  48. Role of ROS-Induced DNA Damage in Mitochondria-Regulated Apoptosis
    Anne Tann; Fiscal Year: 2012
    ..are endogenously produced due to leakage of partially reduced O2- anion radical species from the mitochondrial respiration complexes...
  49. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..elevated blood ketone levels and a lower glycemic index which force cells to rely more heavily on mitochondrial respiration, as opposed to glycolysis, for energy production...
  50. Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine &N-Mustard Activity
    Jerry D Glickson; Fiscal Year: 2013
    ..4, pHe=6.85 or !pH=-0.45. Steady state lactate in the tumor increased 3-fold relative to pre-LND levels.] Respiration, EKG, electrolyte levels and blood oxygenation did not change, while blood analysis is still in progress...
    Michael Regnier; Fiscal Year: 2013
    ..cycling and may affect other cellular ATPases, we will measure cardiac ATP synthesis and mitochondrial respiration, as well as high energy phosphate utilization, energetic reserve and oxygen consumption under basal conditions ..
    Jack L Feldman; Fiscal Year: 2012
    ..with sleep disordered breathing that we hypothesize results from the loss of neurons in brain areas controlling respiration. If breathing is to be understood in normal and in pathological conditions, the site(s) and mechanisms for ..
    Orian S Shirihai; Fiscal Year: 2013
    ..We also found that consumption of the ROS scavenger, n-acetyl cysteine, increased respiration and decreased body fat in vivo...
  54. Pathobiology of C. neoformans in the Central Nervous System
    John R Perfect; Fiscal Year: 2012
    ..stress genes;3) signaling pathway genes;4) high temperature growth genes;5) impact of mitochondria and respiration;6) influence of attenuated null mutants on host immunity...
  55. Genetic Control of Heart Function in a Hibernating Mammal
    Matthew T Andrews; Fiscal Year: 2010
    ..The fundamental adaptation present in natural hibernators is greatly reduced body temperature, metabolism and respiration- conditions that buy precious time in cases of myocardial ischemia, traumatic injury and cardiac arrest...
  56. Modulation of Mitochondrial Function by Pro-Oxidants
    LUKE IGNATIUS SZWEDA; Fiscal Year: 2010
    ..for the maintenance of cardiac energy status and function, mitochondria exhibit declines in the rate of respiration and oxidative phosphorylation during ischemia, with further age-dependent deficits evident upon reperfusion...
  57. HPV, Tumor Metabolism and Radiosensitivity in Head and Neck Cancer
    Hyeong Reh Choi Kim; Fiscal Year: 2013
    ..Taken together, our working hypothesis is that HPV-positive HNSCC cells rely on mitochondrial respiration with decreased glucose metabolism, whereas smoking-associated/chemically-induced HNSCC cells heavily rely on ..
  58. The role of the primitive choana in amniote craniofacial morphogenesis
    John Abramyan; Fiscal Year: 2013
    ..are the internal nares which connect the oral cavity to the nasal passages and are crucial for proper nasal respiration. In mammals, the choanae are covered by the secondary palate and therefore, open directly into the nasopharynx...
  59. Mammalian SIRT6 Is A Master Regulator Of Glucose Homeostasis
    Raul Mostoslavsky; Fiscal Year: 2013
    ..nutrient stress, metabolism is switched to glycolysis, increasing lactate production and reducing mitochondrial respiration. This switch is critical to maintain cells during periods of starvation or hypoxia;furthermore, recent studies ..
  60. Cell Survival and Death in Oxidant Lung Injury
    MICHAEL A O'REILLY; Fiscal Year: 2013
    ..of oxygen-induced newborn lung disease because elevated levels of oxygen (hyperoxia) suppress mitochondrial respiration and damage mitochondrial DNA...
  61. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Enhancing brain mitochondrial respiration could conceivably benefit diseases with reduced brain electron transport chain enzyme activities...
  62. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..g., arterial blood pressure, heart rate, heart rate variability, and respiration rate) during an immediately after stimulation and will follow-up animals up to 1 week after the treatment...
  63. Central Respiratory Effects of Organophosphate Poisoning
    Romolo J Gaspari; Fiscal Year: 2010
    ..Paydarfar has extensive experience in respiration-related neurophysiology...
  64. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..In association with low NO, the cells have reduced mitochondria numbers &respiration, which is accompanied by ~3-fold increase in glycolysis for energy production...
  65. Novel 3D Catheter Tracking System for Intracardiac Navigation
    DORON HARLEV; Fiscal Year: 2009
    ..are all plagued by significant limitations, including tracking distortions and inadequate correction for respiration and other motion artifacts...
    Larry Miller; Fiscal Year: 2006
    ..To achieve these specific aims the PI plans to: 1) determine the effect of respiration on the position and pressure relationships of the intrinsic LES and CD as components of the GEJHPZ...
  67. Ninth International Conference on the Chemistry and Biology of Mineralized Tissue
    Paul Krebsbach; Fiscal Year: 2007
    ..teeth is essential for the activities of normal daily life in locomotion, mineral metabolism, organ protection, respiration, mastication, and proper nutrition and digestion, but the factors and their complex interactions responsible ..
  68. Physiological and Emotional Reactivity to Pain after Physical and Sexual Abuse
    KARIN N WESTLUND-HIGH; Fiscal Year: 2011
    ..Recent evidence suggests controlling rate and pattern of respiration can restore an increase in HRV. Dr...
  69. Coordination of Respiration with Deglutition & Phonation in Ataxia-Telangiectasia
    Maureen Lefton Greif; Fiscal Year: 2007
    ..We will use Respirodeglutometric (RDT) instrumentation to characterize the respiration during deglutition in patients with A-T...
  70. Microxymetry Techniques for Cardiomocyte Respiration
    Govindasamy Ilangovan; Fiscal Year: 2005
    ..The specific aims of the proposal are: (i) to study the respiration (both as such and stimulated by added stimulants) of cardiomyocytes (both cultured cells and freshly isolated ..
    H Zielke; Fiscal Year: 1990
    ..It is known that the adenosine agonist phenylisopropyl adenosine (PIA) causes apnea, decreased respiration, and death; furthermore, young rabbits are susceptible to death from PIA at a five-fold lower concentration ..
  72. Tilt/Recline Adjustment by Subjects with ALS using Brain Computer Interfaces
    Jane Huggins; Fiscal Year: 2009
    ..provide such people with independent control of power tilt/recline for pressure relief, comfort, and improved respiration. This experimental/development grant (R21) application will support the prototype development of a BCI to ..
    Laurence Becker; Fiscal Year: 1991
    ..We have previously described in cases of SIDS specific changes in neural structures concerned with control of respiration (brain stem, vagus nerve) and more recently found elevated levels of catecholamines (CA), mainly dopamine in ..
    HAROLD KLOPFENSTEIN; Fiscal Year: 1992
    ..progresses, heart size decreases and the relative sizes of the chambers fluctuate depending on the phase of respiration. Abrupt collapse of portions of the atria and later the right ventricle occur and pulsus paradoxus increases...
  75. Planning Grant for Genome-Wide Association Study of Craniofacial Microsomia
    JACQUELINE R contact STARR; Fiscal Year: 2010
    ..Typically affecting the jaw and ear, CFM impairs basic functions such as hearing, speech, respiration, and chewing, in addition to its aesthetic effects. It can be life-threatening due to airway compromise...