left ventricular function

Summary

Summary: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.

Top Publications

  1. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
  2. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
  3. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
  4. ncbi Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model
    Alexander Schuh
    IZKF BIOMAT, Aachen, Germany
    Basic Res Cardiol 103:69-77. 2008
  5. ncbi Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel
    Thorsten Dill
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    Am Heart J 157:541-7. 2009
  6. ncbi A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    Matthias Manz
    Department of Cardiology, Marienhof Hospital, Koblenz, Germany
    Cardiology 100:149-55. 2003
  7. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
  8. ncbi Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction
    Javier Ganame
    Cardiology Department, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Eur Heart J 30:1440-9. 2009
  9. ncbi Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    Mikko Kankaanpaa
    Turku PET Centre, University of Turku, FIN 20521, Turku, Finland
    J Clin Endocrinol Metab 91:4689-95. 2006
  10. ncbi Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance
    A M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 8:417-26. 2006

Detail Information

Publications297 found, 100 shown here

  1. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
    ..We investigated the effect of addition of an angiotensin-receptor blocker to current treatments...
  2. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
    ..The purpose of this study was to compare the prognostic power of new fractal and traditional measures of R-R interval variability as predictors of death after acute myocardial infarction...
  3. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  4. ncbi Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model
    Alexander Schuh
    IZKF BIOMAT, Aachen, Germany
    Basic Res Cardiol 103:69-77. 2008
    ..of human endothelial progenitor cells (EPCs) and stromal-cell derived factor-1alpha (SDF-1alpha) on left ventricular function in a chronic setting after myocardial infarction in cyclosporine treated rats...
  5. ncbi Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel
    Thorsten Dill
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    Am Heart J 157:541-7. 2009
    Serial cardiac magnetic resonance imaging (CMR) is the reference standard for evaluating left ventricular function, wall motion, and infarct size in patients with acute myocardial infarction, as well as remodeling during follow-up...
  6. ncbi A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    Matthias Manz
    Department of Cardiology, Marienhof Hospital, Koblenz, Germany
    Cardiology 100:149-55. 2003
    ..Thus, a single intravenous dose of ivabradine produced a substantial reduction in resting heart rate without affecting LV function in patients with regional or global LV dysfunction...
  7. ncbi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
    ..To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI)...
  8. ncbi Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction
    Javier Ganame
    Cardiology Department, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Eur Heart J 30:1440-9. 2009
    ..Magnetic resonance imaging (MRI) can be used to identify MI, myocardial haemorrhage, and microvascular obstruction (MVO), as well as measure LV volumes, function, and mass...
  9. ncbi Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    Mikko Kankaanpaa
    Turku PET Centre, University of Turku, FIN 20521, Turku, Finland
    J Clin Endocrinol Metab 91:4689-95. 2006
    ..We evaluated myocardial and epicardial fat, left ventricular (LV) function, and metabolic risk factors in nine (five lean, four moderately obese) men...
  10. ncbi Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance
    A M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 8:417-26. 2006
    ..These novel data have particular importance for clinical practice and clinical trials using CMR...
  11. ncbi Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators
    M R Bristow
    Division of Cardiology, University of Colorado HSC, Denver 80262, USA
    Circulation 94:2807-16. 1996
    ..We conducted a multicenter, placebo-controlled trial designed to establish the efficacy and safety of carvedilol, a "third-generation" beta -blocking agent with vasodilator properties, in chronic heart failure...
  12. ncbi Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction
    Stijntje D Roes
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:930-6. 2007
    ..In conclusion, infarct size on contrast-enhanced MRI may be superior to LVEF and LV volumes for predicting long-term mortality in patients with healed myocardial infarction...
  13. ncbi Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function
    Roberto M Saraiva
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Soc Echocardiogr 23:172-80. 2010
    ..To assess its potential value, the authors addressed whether LA epsilon and SR measured in normal subjects correlates with other Doppler echocardiographic parameters that evaluate LA function and left ventricular function.
  14. pmc Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function
    Kenichi Nakajima
    Department of Nuclear Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan
    Ann Nucl Med 24:125-35. 2010
    ..Based on the electrocardiography-gated single-photon emission computed tomography (SPECT), left ventricular function, including ventricular volumes, systolic and diastolic functions and systolic wall thickening were also ..
  15. ncbi Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction
    E A Liehn
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany
    J Cell Mol Med 12:496-506. 2008
    ....
  16. ncbi Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity
    James R Bell
    Cardiovascular Division, King s College London, Rayne Institute, St Thomas Hospital, London, UK
    Am J Physiol Heart Circ Physiol 294:H613-21. 2008
    ..Data are consistent with the hypothesis that PLM modulates Na-K-ATPase activity, indirectly affecting intracellular Ca and hence contractile function...
  17. ncbi Direct comparison of magnetic resonance imaging and conductance microcatheter in the evaluation of left ventricular function in mice
    Christoph Jacoby
    Department of Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Basic Res Cardiol 101:87-95. 2006
    ..In summary, our data demonstrate that absolute volumetric values are strikingly underestimated by conduction catheter measurements and that even detection of directional changes with this method may not always be feasible...
  18. ncbi Elevated homocysteine is associated with reduced regional left ventricular function: the Multi-Ethnic Study of Atherosclerosis
    Khurram Nasir
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:180-7. 2007
    ..In this study, we aim to investigate the relationship between Hcy levels and regional left ventricular function in an asymptomatic population.
  19. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
    ..Beta-adrenergic receptor stimulation influences the production of cytokines heralding the possibility of modulating cytokine production by beta-adrenergic blockers...
  20. ncbi The effect of biventricular pacing after coronary artery bypass grafting: a prospective randomized trial of different pacing modes in patients with reduced left ventricular function
    Frank Eberhardt
    Medical Clinic II, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 137:1461-7. 2009
    Biventricular pacing acutely improves left ventricular function in patients with heart failure and left ventricular dyssynchrony...
  21. ncbi Effects of deflazacort on left ventricular function in patients with Duchenne muscular dystrophy
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 91:769-72. 2003
  22. ncbi Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
    J Am Coll Cardiol 47:1-8. 2006
    ....
  23. ncbi Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarction
    Christian Stumpf
    Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Heart Fail 10:733-9. 2008
    ..This effect was associated with a significant decrease in pro-inflammatory cytokine and chemokine levels (TNF-alpha, IL-6, MCP-1) and furthermore resulted in a reduced myocardial infiltration of macrophages...
  24. ncbi Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 50:768-77. 2007
    ..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
  25. ncbi Positive effects of nitric oxide on left ventricular function in humans
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Medical Clinic I, Pauwelsstr 30, 52074 Aachen, Germany
    Eur Heart J 27:1699-705. 2006
    ..The myocardial effect of tonically released nitric oxide (NO) in humans is still not known. We tested the hypothesis that low-dose NO exerts positive effects on left ventricular (LV) function...
  26. ncbi Ischemic preconditioning and preinfarction angina in the clinical arena
    Shereif H Rezkalla
    Department of Cardiology, Marshfield Clinic, Marshfield, WI 54449, USA
    Nat Clin Pract Cardiovasc Med 1:96-102. 2004
    ..Exercise seems to be an important way to induce preconditioning in humans and preserves it in the elderly...
  27. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  28. ncbi Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis
    Anja Zagrosek
    Franz Volhard Klinik, Kardiologie, Charite Campus Buch, HELIOS Klinikum Berlin, Universitatsmedizin Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 2:131-8. 2009
    ..We sought to assess the value of cardiac magnetic resonance (CMR) to monitor the spectrum of myocarditis-related injuries over the course of the disease...
  29. ncbi Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease
    Rene A Tio
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 50:214-9. 2009
    ..Myocardial perfusion is the main determinant of left ventricular function in patients with IHD. The prognostic value of LVEF has been widely established...
  30. ncbi Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the
    Hyun Jae Kang
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Circulation 114:I145-51. 2006
    ..In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation...
  31. ncbi Practical value of cardiac magnetic resonance imaging for clinical quantification of aortic valve stenosis: comparison with echocardiography
    Shelton D Caruthers
    Cardiovascular Magnetic Resonance Laboratories, Barnes Jewish Hospital, Cardiovascular Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 108:2236-43. 2003
    ....
  32. ncbi Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties
    Matthew J Price
    Division of Cardiology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
    Int J Cardiol 111:231-9. 2006
    ..Since there is no need for immune suppression or clinical expertise, IV infusion of MSCs may expand the potential clinical application of stem cell therapy...
  33. ncbi Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay
    D A Kass
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 99:1567-73. 1999
    ....
  34. pmc Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 20:539-51. 2007
    ..This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo...
  35. ncbi Echocardiographic measurement of fluid responsiveness
    Cyril Charron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne, France
    Curr Opin Crit Care 12:249-54. 2006
    ..In the last few years, several French teams have used echocardiography to develop new parameters of fluid responsiveness, taking advantage of its ability to monitor cardiac function beat by beat during the respiratory cycle...
  36. ncbi MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men
    Wei Liu
    Dept of Biomedical Engineering, Case Western Reserve Univ, Wickenden 427, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Am J Physiol Heart Circ Physiol 291:H2515-21. 2006
    ....
  37. ncbi Role of imaging in cardiac stem cell therapy
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 49:1137-48. 2007
    ..In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability.
  38. ncbi The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis
    Robert J Burns
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Am Coll Cardiol 39:30-6. 2002
    ....
  39. ncbi Thyroid stimulating hormone and left ventricular function
    Amjid Iqbal
    Department of Cardiology, University Hospital of North Norway, 9038 Tromsø, Norway
    J Clin Endocrinol Metab 92:3504-10. 2007
    ..Overt hypo- and hyperthyroidism are associated with cardiac disease, whereas this relation is more uncertain regarding subclinical thyroid dysfunction...
  40. ncbi Operator induced variability in left ventricular measurements with cardiovascular magnetic resonance is improved after training
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK
    J Cardiovasc Magn Reson 9:777-83. 2007
    ..The aim of the study was to assess the interobserver variability of the manual planimetry of LV contours amongst two experienced and six inexperienced operators before and after a two months training period...
  41. ncbi Analysis of regional left ventricular function by cineventriculography, cardiac magnetic resonance imaging, and unenhanced and contrast-enhanced echocardiography: a multicenter comparison of methods
    Rainer Hoffmann
    University Rheinisch Westfälischen Technischen Hochschule Aachen, Aachen, Germany
    J Am Coll Cardiol 47:121-8. 2006
    ..To define the use of cineventriculography, cardiac magnetic resonance imaging (cMRI), and unenhanced and contrast-enhanced echocardiography for detection of left ventricular (LV) regional wall motion abnormalities (RWMA)...
  42. pmc Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
    Susheel Gundewar
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 104:403-11. 2009
    ..This study demonstrates that metformin significantly improves left ventricular function and survival via activation of AMPK and its downstream mediators, eNOS and PGC-1alpha, in a murine model ..
  43. ncbi Layer-specific strain analysis by speckle tracking echocardiography reveals differences in left ventricular function between rats and humans
    Noa Bachner-Hinenzon
    Faculty of Biomedical Engineering, Technion Israel Institute of Technology, Haifa, Israel
    Am J Physiol Heart Circ Physiol 299:H664-72. 2010
    ....
  44. ncbi Utility of cardiac biomarkers in predicting infarct size, left ventricular function, and clinical outcome after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
    Stanley Chia
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Interv 1:415-23. 2008
    ....
  45. ncbi Effect of long-term cocaine use on regional left ventricular function as determined by magnetic resonance imaging
    Shiquan Ren
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Cardiol 97:1085-8. 2006
    ..The average diastolic strain in 5 ventricular segmentations was significantly less in the cocaine users (p<0.05). In conclusion, long-term cocaine use may be associated with regional LV dysfunction, especially diastolic dysfunction...
  46. ncbi Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    D Westermann
    Department of Cardiology and Pneumology, Charite University Hospital, Benjamin Franklin Campus, Berlin, Germany
    Diabetologia 49:2507-13. 2006
    We investigated the effect of SB 203580, a pharmacological inhibitor of p38 mitogen-activated protein kinase (MAPK), on cardiac inflammation, cardiac fibrosis, and left ventricular function using an animal model of diabetic cardiomyopathy.
  47. ncbi Transplantation of human umbilical vein endothelial cells improves left ventricular function in a rat model of myocardial infarction
    Marc W Merx
    Medizinische Klinik I, Universitatsklinikum Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Basic Res Cardiol 100:208-16. 2005
    ..Since human umbilical vein endothelial cells (HUVEC) harbor the potential for transdifferentiation, we studied the functional effects of HUVEC transplantation in a rat model of MI...
  48. ncbi Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea
    Yasuyuki Kaneko
    Sleep Research Laboratories, Toronto Rehabilitation Institute, Toronto General Hospital, ON M5G 2C4, Canada
    N Engl J Med 348:1233-41. 2003
    ..We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function...
  49. ncbi Doppler-derived parameters of diastolic left ventricular function in preterm infants with a birth weight <1500 g: reference values and differences to term infants
    Lothar Schmitz
    Department of Pediatric Cardiology, Charite Medical Center, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Early Hum Dev 76:101-14. 2004
    ..Although doing well under physiological conditions, preterm neonates may be at higher risk for diastolic dysfunction than term infants when an additional preload challenge is encountered...
  50. ncbi The effects of short term statin treatment on left ventricular function and inflammatory markers in patients with chronic heart failure
    Cemil Gurgun
    Ege University Faculty of Medicine, Cardiology Department, Turkey
    Int J Cardiol 123:102-7. 2008
    ..In this study, we aimed to evaluate the impact of 12-week fluvastatin therapy on the inflammatory cytokines and the ventricular performance markers in patients with heart failure...
  51. ncbi Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluation
    Daniel Kim
    Department of Radiology, University of Virginia Health System, Rm 1175, MR 4 Bldg, 409 Lane Rd, Charlottesville, VA 22908, USA
    Radiology 230:862-71. 2004
    ..7 x 2.7 mm and 60 msec, respectively. E(cc) measured at cine DENSE MR imaging correlated well with that measured at conventional MR imaging tagging (slope = 0.88, intercept = 0.00, R = 0.87)...
  52. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery.
  53. ncbi Transcoronary transplantation of progenitor cells after myocardial infarction
    Birgit Assmus
    Division of Cardiology and Molecular Cardiology, Department of Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1222-32. 2006
    ..of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction...
  54. ncbi Natriuretic peptides as markers of cardiotoxicity during doxorubicin treatment for non-Hodgkin's lymphoma
    T Nousiainen
    Department of Medicine, Kuopio University Hospital and University of Kuopio, Finland
    Eur J Haematol 62:135-41. 1999
    ..that neuroendocrine activation - increased concentrations of plasma natriuretic peptides - occurs when left ventricular function has reduced substantially and its compensatory capacity has been exceeded resulting in atrial and ..
  55. ncbi Relationship of left atrial appendage function to left ventricular function
    Asha Mahilmaran
    Institutefor Cardiac Treatment and Research, Southern Railway Hospital, Chennai
    Indian Heart J 56:293-8. 2004
    The study was conducted to evaluate the relationship of left atrial appendage function to left ventricular function and to analyze, if left ventricular dysfunction predisposed to left atrial appendage thrombus formation even in the ..
  56. ncbi Automated function imaging: a new operator-independent strain method for assessing left ventricular function
    H Belghitia
    Département de chirurgie cardiaque, Hopital Cardiologique du Haut Leveque, Avenue de Magellan, Pessac
    Arch Cardiovasc Dis 101:163-9. 2008
    ..To facilitate clinical application, speckle tracking has been integrated into the most recent echocardiographic systems for quick, automated evaluation of left ventricular function (Automated Function Imaging, AFI).
  57. ncbi Injection of adeno-associated viral vector encoding vascular endothelial growth factor gene in infarcted swine myocardium: MR measurements of left ventricular function and strain
    Alexis Jacquier
    Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207 B, San Francisco, CA 94134 0628, USA
    Radiology 245:196-205. 2007
    ....
  58. ncbi Acute hemodynamic effects of cardiac resynchronization therapy in patients with poor left ventricular function during cardiac surgery
    Mohamed A Soliman Hamad
    Department of Cardiothoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Card Surg 24:585-90. 2009
    ..We investigated the acute hemodynamic response using LVdP/dt(max) in patients with depressed LV function and conduction disturbances undergoing cardiac surgery...
  59. ncbi Minimized extracorporeal circulation in coronary artery bypass surgery is equivalent to standard extracorporeal circulation in patients with reduced left ventricular function
    T Puehler
    Department of Cardiothoracic Surgery, Medical Center University Regensburg, Regensburg, Germany
    Thorac Cardiovasc Surg 58:204-9. 2010
    ..We analyzed the clinical outcome of patients with reduced left ventricular function who underwent coronary artery bypass surgery with MECC or with standard ECC.
  60. ncbi Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study
    S R Ommen
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 102:1788-94. 2000
    ..However, accurate prediction of filling pressures for an individual patient requires a stepwise approach incorporating all available data...
  61. ncbi Evaluation of left ventricular function in anesthetized patients using femoral artery dP/dt(max)
    Stefan G De Hert
    Department of Anesthesiology, University Hospital Antwerp, Edegem, Belgium
    J Cardiothorac Vasc Anesth 20:325-30. 2006
    ..The purpose of this study was to compare dP/dt(max) estimated from a femoral artery pressure tracing to left ventricular (LV) dP/dt(max) during various alterations in myocardial loading and contractile function...
  62. ncbi The late consequences of anthracycline treatment on left ventricular function after treatment for childhood cancer
    Lubomir Elbl
    Department of Cardiopulmonary Testing, Faculty Hospital of Masaryk University, Jihlavska 20, 625 00 Brno, Czech Republic
    Eur J Pediatr 162:690-6. 2003
    The purpose of this study was to determine the incidence of changes in left ventricular function in patients in long-term remission after treatment with anthracyclines for a childhood malignancy...
  63. ncbi Quantitative evaluation of regional left ventricular function using three-dimensional speckle tracking echocardiography in patients with and without heart disease
    Francesco Maffessanti
    University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 104:1755-62. 2009
    ..2D) speckle tracking echocardiography has been shown to be useful in the assessment of regional left ventricular function, it is limited by the assumption that speckles can be tracked frame-to-frame within the imaging plane, ..
  64. pmc Left ventricular function and C-reactive protein levels in acute myocardial infarction
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 105:917-21. 2010
    ..This suggests that inflammation is related to the ventricular remodeling processes, independently of LV systolic function...
  65. ncbi Effects of sex, gonadectomy, and oestrogen substitution on ischaemic preconditioning and ischaemia-reperfusion injury in mice
    X Song
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockhom, Sweden
    Acta Physiol Scand 177:459-66. 2003
    ..Ischaemic preconditioning (IPC) has been demonstrated to protect heart function and viability, but has been predominantly studied in male animals...
  66. pmc Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy
    Kenneth C Bilchick
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    JACC Cardiovasc Imaging 1:561-8. 2008
    ....
  67. ncbi Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice
    Fadi N Salloum
    Division of Cardiology, Department of Internal, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 294:H1398-406. 2008
    ..05). Sildenafil attenuates ischemic cardiomyopathy in mice by limiting necrosis and apoptosis and by preserving left ventricular function possibly through a nitric oxide-dependent pathway.
  68. ncbi Olmesartan improves left ventricular function in pressure-overload hypertrophied rat heart by blocking angiotensin II receptor with synergic effects of upregulation of angiotensin converting enzyme 2
    - Kaiqiang Ji
    Department of Thoracic and Cardiovascular Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Adv Cardiovasc Dis 3:103-11. 2009
    ..2 mg/kg per day) was administered subcutaneously by osmotic minipumps (Olm groups). Left ventricular function was measured by Langendorff perfusion...
  69. ncbi Impact of acute myocardial edema on left ventricular function
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Anesthesiology, University of Texas Medical School, Houston, Texas, USA
    J Invest Surg 19:31-8. 2006
    ..3% to 77.7 +/- 0.3% (p < .05). PRSW and dP/dt(max) did not decrease in either group. Diastolic parameters did not change significantly. We conclude that acute myocardial edema without myocardial injury does not impair LV function...
  70. ncbi Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction
    Beatriz Pelacho
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Tissue Eng Regen Med 1:51-9. 2007
    ....
  71. ncbi Impact of different pacing modes on left ventricular function following cardiopulmonary bypass
    O Dzemali
    Department for Cardiothoracic Surgery, J W Goethe University Hospital, Frankfurt am Main, Germany
    Thorac Cardiovasc Surg 56:87-92. 2008
    ..This prospective study investigates hemodynamic effects and outcomes of perioperative temporary biventricular pacing in patients with heart failure undergoing heart surgery...
  72. ncbi Global left ventricular function in cardiac CT. Evaluation of an automated 3D region-growing segmentation algorithm
    Georg Mühlenbruch
    Department of Diagnostic Radiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Radiol 16:1117-23. 2006
    ..2%. On the basis of a good contrast-enhanced data set, a left ventricular volume analysis using the new semi-automated region-growing segmentation algorithm is technically feasible, accurate and more time-effective...
  73. pmc Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy
    S F Nagueh
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX, USA
    Circulation 104:128-30. 2001
    ..We tested whether humans with FHCM also consistently showed reduced myocardial TD velocities, irrespective of LVH...
  74. ncbi Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
    Hung Fat Tse
    Division of Cardiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Eur J Heart Fail 9:747-53. 2007
    ..To determine the optimal bone marrow (BM) cell types, and their potential mechanisms of action for neovascularization in chronic ischaemic myocardium...
  75. ncbi Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:1933-9. 2004
    ....
  76. ncbi Ventricular pacing lead location alters systemic hemodynamics and left ventricular function in patients with and without reduced ejection fraction
    Randy Lieberman
    Department of Cardiology, Harper University Hospital, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 48:1634-41. 2006
    ..We compared left ventricular (LV) systolic and diastolic function during right ventricular (RV), LV, and biventricular (BiV) pacing in patients with narrow QRS duration with and without LV dysfunction...
  77. ncbi [Effects of autologous bone marrow derived CD34+ stem cells on the left ventricular function following myocardial infarction]
    László Balogh
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Altalános Orvostudományi Kar Kardiológiai Intézet, Debrecen Pf 1 4004
    Orv Hetil 148:243-9. 2007
    ..8 patients with impaired left ventricular function were transplanted with CD34+ bone marrow stem cells 12 +/- 1 day after the acute coronary event...
  78. ncbi Assessment of left ventricular function by cardiac ultrasound
    James D Thomas
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 48:2012-25. 2006
    ..This review also discusses the clinical impact of echocardiography and its future directions and developments...
  79. pmc Improved Stratification of Autonomic Regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISAR-Risk)
    Axel Bauer
    Medizinische Klinik und Deutsches Herzzentrum München der Technischen Universität München, Munchen, Germany
    Eur Heart J 30:576-83. 2009
    ..To investigate the combination of heart rate turbulence (HRT) and deceleration capacity (DC) as risk predictors in post-infarction patients with left ventricular ejection fraction (LVEF) > 30%...
  80. ncbi Transit of blood flow through the human left ventricle mapped by cardiovascular magnetic resonance
    Ann F Bolger
    Department of Medicine, University of California, San Francisco, California 94110, USA
    J Cardiovasc Magn Reson 9:741-7. 2007
    ..Quantification of the components of multidirectional flow in the normal left ventricle (LV) is lacking, making it difficult to put the changes observed with LV dysfunction and cardiac surgery into context...
  81. pmc Cardiac involvement in patients with Becker muscular dystrophy: new diagnostic and pathophysiological insights by a CMR approach
    Ali Yilmaz
    Division of Cardiology, Robert Bosch Krankenhaus, Stuttgart, Germany
    J Cardiovasc Magn Reson 10:50. 2008
    ..Cardiovascular magnetic resonance (CMR) has the potential to detect cardiac involvement by depicting early scar formation that may appear before onset of wall motion abnormalities...
  82. pmc Dramatic reversal of derangements in muscle metabolism and left ventricular function after bariatric surgery
    Joshua G Leichman
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Med 121:966-73. 2008
    ..The study objective was to define muscle metabolic and cardiovascular changes after surgical intervention in clinically severe obese patients...
  83. ncbi Investigating myocardial motion by MRI using tissue phase mapping
    Bernd Jung
    Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg University, Hugstetterstr 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 29:S150-7. 2006
    ..In contrast to other imaging modalities such as echocardiography left ventricular performance can be assessed without limited anatomical or functional coverage...
  84. ncbi Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis
    Karen Hogg
    Department of Cardiology, Western Infirmary, Glasgow G12 8QQ, Scotland, United Kingdom
    J Am Coll Cardiol 43:317-27. 2004
    ..Though much has recently been learned about the syndrome of HF-PSF, many questions remain to be answered, not least how it should be treated...
  85. ncbi Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure
    Paul Mulder
    INSERM U644, UFR de Medecine et de Pharmacie, Rouen, France
    Circulation 109:1674-9. 2004
    ..However, the long-term effects of HRR on cardiac function and remodeling are unknown...
  86. ncbi Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction
    Monique C de Waard
    Experimental Cardiology, Dept of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands
    J Appl Physiol (1985) 107:928-36. 2009
    ..These findings suggest that even when regular physical activity fails to prevent an acute MI, it can still act to improve cardiac function and survival after MI...
  87. ncbi Effect of catheter-based transendocardial delivery of stromal cell-derived factor 1alpha on left ventricular function and perfusion in a porcine model of myocardial infarction
    Karl Christian Koch
    Department of Cardiology, RWTH Aachen University, Pauwelstrasse 30, 52074 Aachen, Germany
    Basic Res Cardiol 101:69-77. 2006
    ..Myocardial regeneration after myocardial infarction can occur via stem cell recruitment. Stromal cell-derived factor 1alpha (SDF-1alpha) has been shown to be critical for stem cell homing to injured tissue...
  88. ncbi The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients
    Panayiotis A Economides
    Microcirculation Laboratory, Palmer 317, BIDMC West, 1 Deaconess Rd, Boston, MA 02215, USA
    Diabetes 54:204-11. 2005
    ..vitamin E treatment over a 12-month period on the vascular reactivity of micro- and macrocirculation and left ventricular function in diabetic patients...
  89. ncbi Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial
    R Hambrecht
    Klinik für Innere Medizin Kardiologie, Universitat Leipzig, Herzzentrum GmbH, Russenstrasse 19, 04289 Leipzig, Germany
    JAMA 283:3095-101. 2000
    ..Exercise training in patients with chronic heart failure improves work capacity by enhancing endothelial function and skeletal muscle aerobic metabolism, but effects on central hemodynamic function are not well established...
  90. ncbi Evaluation of the effect of a concurrent chronic total occlusion on long-term mortality and left ventricular function in patients after primary percutaneous coronary intervention
    Bimmer E P M Claessen
    Department of Cardiology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    JACC Cardiovasc Interv 2:1128-34. 2009
    ..The aim of this study was to evaluate the effect of a concurrent chronic total occlusion (CTO) in patients with ST-segment elevation myocardial infarction (STEMI) on long-term mortality and left ventricular ejection fraction (LVEF)...
  91. ncbi Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction
    Carolina Gandia
    Fundación Hospital General Universitario, Consorcio Hospital General Universitario de Valencia, Avenida Tres Cruces s n, 46014 Valencia, Spain
    Stem Cells 26:638-45. 2008
    ..However, angiogenesis was increased relative to control-treated animals. Taken together, these data suggest that DPSC could provide a novel alternative cell population for cardiac repair, at least in the setting of acute MI...
  92. ncbi Intravenous delivery of autologous mesenchymal stem cells limits infarct size and improves left ventricular function in the infarcted porcine heart
    Ulf Krause
    Department of Hematology, University of Heidelberg, Heidelberg, Germany
    Stem Cells Dev 16:31-7. 2007
    ..02) and higher +dp/dt (4,570 +/- 540 vs. 6,742 +/- 700 mmHg/s, p = 0.03) during inotropic stimulation. Systemic intravenous delivery of MSCs to pigs limits myocardial infarct size and is an attractive approach for tissue repair...
  93. ncbi Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia
    Yukio Mizuguchi
    Cardiovascular Section, Higashi Tokushima National Hospital, National Hospital Organization, 1 1 Ohmukai kita, Ohtera, Itano cho, Itano gun, Tokushima 779 0193, Japan
    Circ J 72:538-44. 2008
    ....
  94. pmc Magnetic resonance imaging analysis of cardiac cycle events in diabetic rats: the effect of angiotensin-converting enzyme inhibition
    Ahmad I M Al-Shafei
    Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School of Clinical Medicine, Forvie Site, Robinson Way, Cambridge CB2 2PZ, UK
    J Physiol 538:555-72. 2002
    ....
  95. ncbi Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function
    Craig S Broberg
    Divisions of Cardiology, Oregon Health and Science University, Portland, Oregon 97221, USA
    J Am Soc Echocardiogr 16:814-23. 2003
    ..The myocardial performance index (MPI) is a Doppler-based measure of left ventricular (LV) function. It is noninvasive, independent of LV shape, and does not require dimensional measurements. However, it has never been validated in mice...
  96. ncbi Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats
    A Akula
    Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India
    Pharmacol Res 48:429-35. 2003
    ....
  97. ncbi Glucose-insulin-potassium reduces infarct size when administered during reperfusion
    A K Jonassen
    Department of Medical Physiology, Institute of Medical Biology, University of Tromsø, Norway
    Cardiovasc Drugs Ther 14:615-23. 2000
    ..This study demonstrates that glucose-insulin-potassium administration at the onset of the postischemic reperfusion period is as cardioprotective as administration of GIK during the entire ischemia/reperfusion period...
  98. ncbi MRI assessment of LV relaxation by untwisting rate: a new isovolumic phase measure of tau
    S J Dong
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Heart Circ Physiol 281:H2002-9. 2001
    ..Use of this novel parameter should allow the detailed study of diastolic function in states known to affect filling rates, such as aging, hypertension, and congestive heart failure...
  99. ncbi The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model
    Jiashing Yu
    University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley San Francisco, CA, United States
    Biomaterials 30:751-6. 2009
    ..These results suggest that in situ use of modified polymers may influence the tissue microenvironment and serve as a potential therapeutic agent for patients with chronic heart failure...
  100. pmc Optimal vortex formation as an index of cardiac health
    Morteza Gharib
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:6305-8. 2006
    ..A study of normal and pathological cardiac health in human subjects demonstrates the ability of this global index to distinguish disease states by a straightforward analysis of noninvasive LV measurements...
  101. ncbi Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....

Research Grants64

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..under investigation include: 1) Deferoxamine (DFO) and deferiprone (L1) combination therapy improves left ventricular function more rapidly than DFO/placebo therapy among transfusion dependent beta-thalassemia patients with ..
  2. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2012
    ..These primary myoblasts have demonstrated engraftment and improvement in left ventricular function but with adverse event of arrhythmia...
  3. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    ..murine models of (1) myocardial ischemia-reperfusion with measurement of infarct size and assessment of left ventricular function by echocardiography and pressure-volume loops and (2) post-ischemic inflammation of the cremaster muscle ..
  4. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..whether in the coronary fibrinolysis model in dogs, APT102 promotes improved myocardial perfusion and left ventricular function with minimal bleeding compared with clopidogrel...
  5. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2013
    ..clearly demonstrate that physiological levels of H2S significantly ameliorate MI-R injury and preserve left ventricular function. Preliminary data also indicate that H2S therapy triggers both "early" and "late" myocardial ..
  6. Cell Based Therapies for Cystic Fibrosis
    Tracey L Bonfield; Fiscal Year: 2012
    ..Translational and early-phase clinical research has demonstrated that cell-based therapies may improve left ventricular function, reduce myocardial ischemia and lead to improved lung function...
  7. Inhibition of GRK2 to Prevent Ventricular Remodeling and Heart Failure After CABG
    Shahab A Akhter; Fiscal Year: 2013
    ..bypass grafting (CABG), long-term survival is markedly inferior for patients who present with depressed left ventricular function post-myocardial infarction...
  8. Computational Modeling and Accelerated Aging of the Ascending Aorta
    Jay D Humphrey; Fiscal Year: 2013
    ..to elucidate underlying biomechanical causes of thoracic aortic aneurysms and dissections, diminished left ventricular function due to stiffening of the aorta, and deleterious systemic hemodynamics as well as an improved design of ..
  9. Ubiquitin-like protein modification in diabetic cardiomyopathy
    Jay Yang; Fiscal Year: 2013
    ..factor for both mortality and morbidity following myocardial infarction (MI), especially since post-MI left ventricular function is significantly worse in DM patients...
  10. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2013
    ..defibrillators (ICDs) for the primary prevention of sudden cardiac death in patients with HF and reduced left ventricular function has increased...
  11. The role of the extracellular biophysical and biomechanical milieu in CHDs
    Lauren D Black; Fiscal Year: 2013
    ..Decreased cardiac tropoelastin and procollagen gene expression and decreased left ventricular function in LHH compared to normal hearts suggest that significant deviations from normal ECM composition and ..
  12. Low Thyroid function and myocardial infarction
    Anthony Martin Gerdes; Fiscal Year: 2013
    ..New data from rats shows that TH treatment of MI improved left ventricular function without elevating heart rate and led to a remarkable change in myocyte shape and reduced chamber ..
  13. Pathogen specific imaging of endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2013
    ..PET/MRI, thereby combining a sensitive molecular modality (PET) with a leading modality for assessing left ventricular function which can also detect valvular insufficiency (MRI)...
  14. Treatment of Functional Impairment in Heart Failure Patients with Depression
    Kenneth E Freedland; Fiscal Year: 2012
    ..evaluation will assess depression, HF self-care, and quality of life, as well as medical history, left ventricular function via echocardiography, biomarkers including BNP and CRP, 6-minute walk test performance, physical ..
  15. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2012
    ..relationship of variants in the candidate genes with in-hospital and short-term plasma and left ventricular function markers will be tested in a subset of ~412 confirmed ACS cases who get extensive evaluation and return ..
  16. Myocardial Effects of Erythropoietin During Resuscitation from Cardiac Arrest
    RAUL JAIME GAZMURI; Fiscal Year: 2013
    ..function enabling preservation of left ventricular compli- ance during VF and preservation of left ventricular function after return of spontaneous circulation, (2) whether these effects are mediated through activation and ..
  17. Advanced Glycation End-Products in Human Myocardium
    Martin M LeWinter; Fiscal Year: 2011
    ..obtained in the Operating Room from patients undergoing coronary bypass grafting who have well-preserved left ventricular function. In Aim 1 we will quantify AGE abundance in relation to the presence or absence of DM, HTN and DM+HTN ..
  18. Vagus stimulation protects against cardiac diastolic dysfunction in aging mice
    Yi Fan Li; Fiscal Year: 2010
    ..b>Left ventricular function will be assessed using Millar Pressure-Volume catheter...
  19. Effects of Mechanical Unloading on Myocardial Function and Structure in Humans
    Josef Stehlik; Fiscal Year: 2013
    ..In a subset of patients, LVAD unloading results in sustained improvement of left ventricular function, but the clinical or pathologic features associated with this functional recovery are not well described...
  20. The Jefferson Regional Clinical Center for Heart Failure Network
    David J Whellan; Fiscal Year: 2013
    ..prospective phase 2 clinical trial of the effects of SDD in a cohort of 200 HF subjects with reduced left ventricular function. The primary hypothesis is that SDD will significantly reduce left ventricular end diastolic volume ..
  21. The non-hypertrophic role of calcineurin in regulating cardiac structure-function
    Jennifer Davis; Fiscal Year: 2011
    ..performance, as mice with cardiac-specific calcineurin deletion have normal cardiac morphology but poor left ventricular function and premature death...
  22. Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered Myocardium
    Lauren D Black; Fiscal Year: 2012
    ..function, and 2) the efficacy of myocardial equivalents biomimetically-engineered in vitro in restoring left ventricular function post-MI...
  23. Cardiac regeneration in situ: Is it possible?
    Thomas Force; Fiscal Year: 2012
    ..physiologic consequences of this proliferation by determining whether there is a beneficial effect on left ventricular function. Finally, we will determine whether deletion of GSK-3b can lead to beneficial effects in mice with ..
  24. Exercise and TZD Effects on Myocardial Substrate Metabolism and Function in HIV
    William Todd Cade; Fiscal Year: 2010
    ..GET) program and a thiazolidinedione (TZD), on peripheral and myocardial substrate metabolism and left ventricular function in HIV-infected individuals with impaired glucose tolerance (HIV+IGT)...
  25. Exercise and Stem Cell Engraftment in the Heart Following Myocardial Infarction
    KENNETH BER MARGULIES; Fiscal Year: 2013
    ..While research to date has shown that cell-based therapy can improve left ventricular function in myocardial infarction, low progenitor cell engraftment rates have limited the efficacy of the ..
  26. Miniaturized Distal Vibration System for Penetration of Vascular Occlusions
    STEPHANIE ADI HARRINGTON; Fiscal Year: 2010
    ..of CTOs offers important benefits to the patient including reduced angina symptoms, improved left ventricular function, reduced need for Coronary Artery Bypass Graft (CABG), and a lower incidence of death or Myocardial ..
  27. Microthread-Based Delivery of Human Mesenchymal Stem Cells to Infarcted Hearts
    Glenn R Gaudette; Fiscal Year: 2010
    ..In our second specific aim, we will assess the effects of microthread-mediated hMSC delivery on left ventricular function in the infarcted rat heart in vivo...
  28. Racial Genomic Differences and Heart Failure Outcomes
    Dennis M McNamara; Fiscal Year: 2013
    ..and 500 black subjects, and will examine the impact of racial differences in genetic background on left ventricular function and clinical outcomes...
  29. EXERCISE AND PIOGLITAZONE FOR HIV CARDIOMETABOLIC SYNDROMES
    Kevin Yarasheski; Fiscal Year: 2009
    ..improve endothelial function, reduce atherogenesis, reduce myocardial lipid content and improve left ventricular function in people living with HIV+IR and CVD risk profiles...
  30. ANISOTROPY IN HEALING MYOCARDIAL SCAR TISSUE
    Jeffrey W Holmes; Fiscal Year: 2010
    ..myocardial infarction, the mechanical properties of the healing scar are a critical determinant of left ventricular function, infarct expansion, aneurysm formation and rupture, and ventricular remodeling...
  31. Occluded Artery Trial: Long Term Follow-Up
    Judith S Hochman; Fiscal Year: 2010
    ..3-28 days after myocardial infarction (Ml) and at least one additional high risk feature, either reduced left ventricular function (ejection fraction <50%) or proximal coronary artery occlusion...
  32. Occluded Artery Trial: Long-Term Follow up-Data Coordinating Center
    Sandra Forman; Fiscal Year: 2010
    ..3-28 days after myocardial infarction (Ml) and at least one additional high risk feature, either reduced left ventricular function (ejection fraction <50%) or proximal coronary artery occlusion...
  33. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..means has been conclusively shown to reduce cardiac mortality, less striking beneficial effects on left ventricular function and infarct size reduction have been demonstrated...
  34. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    ..ventricular function and a conductance catheter and Miller micromanometer pressure catheter to measure left ventricular function continuously. The data will be analyzed using repeated measures multivariate analysis of variance...
  35. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 2000
    ..3) to determine whether exercise-training can (a) induce regression or reduction of LVH, (b) improve left ventricular function, and (c) reduce arterial stiffness; and (4) to determine whether the training-induced decrease in BP is ..
  36. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..that can identify patients with increased ACE, prospectively, before the transition to replacement fibrosis and remodeling occurs, may result in preserved left ventricular function thereby improving overall prognosis.
  37. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..infarction will be used to assess the ability of this biologic pump approach to improve hemodynamics and left ventricular function via an afterload-reducing mechanism...
  38. Cord Blood: Treatment for Acute Myocardial Infarction
    William Marshall; Fiscal Year: 2005
    ..stem cells (hUCBC) has been shown to be effective in limiting infarct size and in the preservation of left ventricular function and anatomy in a rat model...
  39. QUANTITATIVE VENTRICULOGRAPHY USING DUAL-ENERGY DSA
    MICHAEL VAN LYSEL; Fiscal Year: 1992
    ..technique to patients with cardiac disease, and quantitatively assess both global and regional left ventricular function during rest and exercise...
  40. RIGHT VENTRICULAR DYSFUNCTION AND TREATMENT
    Marc Semigran; Fiscal Year: 2003
    ..While most previous investigations have concentrated on the abnormalities in left ventricular function, there is evidence that right ventricular (RV) function is a more important determinant of patients ..
  41. Mechanisms Mediating Hypotension to Anthrax Lethal Toxin
    Michael J Kenney; Fiscal Year: 2010
    ..An integrative and multifaceted experimental approach involving sympathetic nerve, cardiac output, left ventricular function, alpha-adrenergic vasoconstrictor, endothelium-dependent and -independent vasodilation, and regional ..
  42. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  43. CARDIAC RESPONSE TO ESTROGEN & HYPERTENSION
    MARK MORTON; Fiscal Year: 1991
    ..that, when moderate hypertension is superimpose on established estrogen- induced cardiac enlargement, left ventricular function will deteriorate and cardiomyopathy amy result...
  44. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..Although, current therapies improve left ventricular function, right heart pathologies are not effectively treated...
  45. GROWTH HORMONE FOR PEDIATRIC DILATED CARDIOMYOPATHY
    Jane Newburger; Fiscal Year: 2001
    ..Secondary outcome variables will include changes in the following parameters: a) Measures of left ventricular function, assessed using echocardiographic techniques, including change in rate- corrected velocity of fiber ..
  46. Dynamic ECG Predictors of Sudden Cardiac Death in Ischemia Cardiomyopathy
    Mary Carey; Fiscal Year: 2007
    ..The study will enroll patients who have had a prior myocardial infarction (Ml) and poor left ventricular function. A high resolution (1000Hz sampling) 12-lead ECG obtained and analyzed for both resting and dynamic ..
  47. REGULATION OF LEFT VENTRICULAR FUNCTION IN HYPERTROPHY
    Song Jung Kim; Fiscal Year: 2003
    ..e., in vivo and in vitro in a large mammalian canine model and in transgenic mouse models, will provide significant new information regarding underlying mechanisms of contractile and relaxation dysfunction in LVH. ..
  48. MOTION CORRECTED TREADMILL NUCLEAR ANGIOGRAPHY
    Jeffrey Lacy; Fiscal Year: 2001
    Peak exercise left ventricular function measured by radionuclide angiography (RNA) is known to have strong prognostic value and therefore can be very helpful for screening patients with a low to intermediate likelihood of CAD...
  49. Conductance to Measure Cardiac Mechanics
    Marc Feldman; Fiscal Year: 2001
    ..The long-term goal of this grant is to quantify left ventricular function in the intact mouse...
  50. Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered Myocardium
    Lauren Black; Fiscal Year: 2009
    ..function, and 3) the efficacy of myocardial equivalents biomimetically-engineered in vitro in restoring left ventricular function post-Mi...
  51. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..changes in ventricular-vascular coupling (Ea/Ees relationship) in these patients to six-month changes in left ventricular function and to clinical outcomes...
  52. STRATEGIES TO LIMIT DEFIBRILLATION AND REPERFUSION INJUR
    Richard Kerber; Fiscal Year: 2002
    ..This preserves left ventricular function after defibrillation and/or reperfusion (i.e., less "stunning")...
  53. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2003
    ..Lastly, we will explore the common and disparate mechanisms whereby these complimentary systems alter left ventricular function. Based on preliminary studies, we advance three hypotheses...
  54. RIGHT & LEFT VENTRICULAR FUNCTION DURING FETAL HYPOXEMIA
    Mark Reller; Fiscal Year: 1990
    ....
  55. Sustained Coronary Stenosis and Hibernating Myocardium
    RAYMOND KUDEJ; Fiscal Year: 2005
    ..potentially due to up-regulation of NO; and B) Adaptive alterations in systolic and diastolic left ventricular function present distal to the ameroid coronary constrictor in swine and in hibernating woodchuck hearts are ..
  56. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ..hours after AMI onset) was initially attributed to myocardial salvage and the resultant preservation of left ventricular function. However, it is now evident that the survival benefit associated with thrombolytic therapy is not ..
  57. IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGY
    RONALD WATSON; Fiscal Year: 2001
    ..The left ventricular function will be quantitated in vivo with pressure volume loop to define the ventricular dysfunction and ..
  58. Racial Differences in the Treatment of Heart Disease
    Paul Heidenreich; Fiscal Year: 2001
    ..counseling and angiography) and heart failure (angiotensin converting enzyme inhibitors, measures of left ventricular function)...
  59. CARDIOVASCULAR STRESS OF SLEEP APNEA AND HEART FAILURE
    Alan Schwartz; Fiscal Year: 2005
    ..is predicated on the notion that sleep apnea increases cardiovascular stress, and further worsens left ventricular function in heart failure patients...
  60. The Cytoskeleton in HAART-Induced Cardiomyopathy
    David Nelson; Fiscal Year: 2006
    ..in patients with DCM or ischemic cardiomyopathy that dystrophin remodeling is a useful indicator of left ventricular function. It has been reported that the 2A protease of Coxsackievirus B3, a major etiologic agent of acquired DCM,..
  61. Myocardial repair by targeted stem cells
    JAMES LARRICK; Fiscal Year: 2009
    ..stem cells (SC) injected into acutely injured as well as chronically ischemic myocardium improve left ventricular function. However, a major limitation of direct infusion or injection of SC is the targeting and retention of ..
  62. Multi-Ethnic Study of Atherosclerosis-Eye Study
    Ronald Klein; Fiscal Year: 2005
    ..characteristics and arteriolar caliber to a wide array of subclinical cardiovascular measures (including left ventricular function defined from cardiac magnetic resonance imaging, peripheral arterial function defined from radial artery ..
  63. Function and regulation of cardiac uncoupling proteins
    Raymond Russell; Fiscal Year: 2009
    ..metabolism and mitochondrial function and (2) to determine the effect of gain or loss of UCP function on left ventricular function and myocyte survival in the setting of ischemia/reperfusion or pressure overload hypertrophy...
  64. THYROID HORMONES AND PHOSPHOLAMBAN ABLATION
    Evangelia Kranias; Fiscal Year: 1999
    ..The hypothesis that will be tested in this FIRCA application is: altered basal left ventricular function and responses to b-adrenergic stimulation of hypo- and hyperthyroid mammalian hearts may be mediated by ..