left ventricular function

Summary

Summary: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.

Top Publications

  1. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
  2. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
  3. ncbi Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel
    Thorsten Dill
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    Am Heart J 157:541-7. 2009
  4. doi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
  5. doi Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction
    Javier Ganame
    Cardiology Department, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Eur Heart J 30:1440-9. 2009
  6. pmc Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
    Susheel Gundewar
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 104:403-11. 2009
  7. ncbi Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction
    Stijntje D Roes
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:930-6. 2007
  8. doi The effect of biventricular pacing after coronary artery bypass grafting: a prospective randomized trial of different pacing modes in patients with reduced left ventricular function
    Frank Eberhardt
    Medical Clinic II, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 137:1461-7. 2009
  9. ncbi Transcoronary transplantation of progenitor cells after myocardial infarction
    Birgit Assmus
    Division of Cardiology and Molecular Cardiology, Department of Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1222-32. 2006
  10. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005

Detail Information

Publications260 found, 100 shown here

  1. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
    ..We investigated the effect of addition of an angiotensin-receptor blocker to current treatments...
  2. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
    ..The purpose of this study was to compare the prognostic power of new fractal and traditional measures of R-R interval variability as predictors of death after acute myocardial infarction...
  3. ncbi Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cel
    Thorsten Dill
    Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany
    Am Heart J 157:541-7. 2009
    Serial cardiac magnetic resonance imaging (CMR) is the reference standard for evaluating left ventricular function, wall motion, and infarct size in patients with acute myocardial infarction, as well as remodeling during follow-up...
  4. doi Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction
    Heikki V Huikuri
    Department of Internal Medicine, University of Oulu, Oulu, Finland
    Eur Heart J 29:2723-32. 2008
    ..To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI)...
  5. doi Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction
    Javier Ganame
    Cardiology Department, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Eur Heart J 30:1440-9. 2009
    ..Magnetic resonance imaging (MRI) can be used to identify MI, myocardial haemorrhage, and microvascular obstruction (MVO), as well as measure LV volumes, function, and mass...
  6. pmc Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
    Susheel Gundewar
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY, USA
    Circ Res 104:403-11. 2009
    ..This study demonstrates that metformin significantly improves left ventricular function and survival via activation of AMPK and its downstream mediators, eNOS and PGC-1alpha, in a murine model ..
  7. ncbi Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction
    Stijntje D Roes
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:930-6. 2007
    ..In conclusion, infarct size on contrast-enhanced MRI may be superior to LVEF and LV volumes for predicting long-term mortality in patients with healed myocardial infarction...
  8. doi The effect of biventricular pacing after coronary artery bypass grafting: a prospective randomized trial of different pacing modes in patients with reduced left ventricular function
    Frank Eberhardt
    Medical Clinic II, University of Lubeck, Lubeck, Germany
    J Thorac Cardiovasc Surg 137:1461-7. 2009
    Biventricular pacing acutely improves left ventricular function in patients with heart failure and left ventricular dyssynchrony...
  9. ncbi Transcoronary transplantation of progenitor cells after myocardial infarction
    Birgit Assmus
    Division of Cardiology and Molecular Cardiology, Department of Medicine III, Johann Wolfgang Goethe University, Frankfurt, Germany
    N Engl J Med 355:1222-32. 2006
    ..of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction...
  10. ncbi Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response
    Matthias Pauschinger
    Department of Internal Medicine II, Cardiology and Pneumonology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Eur J Heart Fail 7:444-52. 2005
    ..Beta-adrenergic receptor stimulation influences the production of cytokines heralding the possibility of modulating cytokine production by beta-adrenergic blockers...
  11. ncbi Effects of deflazacort on left ventricular function in patients with Duchenne muscular dystrophy
    Candice K Silversides
    Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Cardiol 91:769-72. 2003
  12. ncbi Elevated homocysteine is associated with reduced regional left ventricular function: the Multi-Ethnic Study of Atherosclerosis
    Khurram Nasir
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Circulation 115:180-7. 2007
    ..In this study, we aim to investigate the relationship between Hcy levels and regional left ventricular function in an asymptomatic population.
  13. ncbi Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
    Robert W Schrier
    University of Colorado School of Medicine, Division of Renal Diseases and Hypertension, Denver, Colorado 80262, USA
    J Am Coll Cardiol 47:1-8. 2006
    ....
  14. ncbi Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 50:768-77. 2007
    ..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
  15. doi Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarction
    Christian Stumpf
    Department of Cardiology, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Heart Fail 10:733-9. 2008
    ..This effect was associated with a significant decrease in pro-inflammatory cytokine and chemokine levels (TNF-alpha, IL-6, MCP-1) and furthermore resulted in a reduced myocardial infiltration of macrophages...
  16. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated patients...
  17. doi Cardiac magnetic resonance monitors reversible and irreversible myocardial injury in myocarditis
    Anja Zagrosek
    Franz Volhard Klinik, Kardiologie, Charite Campus Buch, HELIOS Klinikum Berlin, Universitatsmedizin Berlin, Berlin, Germany
    JACC Cardiovasc Imaging 2:131-8. 2009
    ..We sought to assess the value of cardiac magnetic resonance (CMR) to monitor the spectrum of myocarditis-related injuries over the course of the disease...
  18. ncbi Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure
    Paul Mulder
    INSERM U644, UFR de Medecine et de Pharmacie, Rouen, France
    Circulation 109:1674-9. 2004
    ..However, the long-term effects of HRR on cardiac function and remodeling are unknown...
  19. ncbi Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the
    Hyun Jae Kang
    Cardiovascular Laboratory, Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Circulation 114:I145-51. 2006
    ..In addition, the potential risk of restenosis associated with G-CSF-based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation...
  20. doi Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease
    Rene A Tio
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 50:214-9. 2009
    ..Myocardial perfusion is the main determinant of left ventricular function in patients with IHD. The prognostic value of LVEF has been widely established...
  21. ncbi Positive effects of nitric oxide on left ventricular function in humans
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Medical Clinic I, Pauwelsstr 30, 52074 Aachen, Germany
    Eur Heart J 27:1699-705. 2006
    ..The myocardial effect of tonically released nitric oxide (NO) in humans is still not known. We tested the hypothesis that low-dose NO exerts positive effects on left ventricular (LV) function...
  22. ncbi Myocardial triglyceride content and epicardial fat mass in human obesity: relationship to left ventricular function and serum free fatty acid levels
    Mikko Kankaanpaa
    Turku PET Centre, University of Turku, FIN 20521, Turku, Finland
    J Clin Endocrinol Metab 91:4689-95. 2006
    ..We evaluated myocardial and epicardial fat, left ventricular (LV) function, and metabolic risk factors in nine (five lean, four moderately obese) men...
  23. ncbi Echocardiographic measurement of fluid responsiveness
    Cyril Charron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne, France
    Curr Opin Crit Care 12:249-54. 2006
    ..In the last few years, several French teams have used echocardiography to develop new parameters of fluid responsiveness, taking advantage of its ability to monitor cardiac function beat by beat during the respiratory cycle...
  24. ncbi MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men
    Wei Liu
    Dept of Biomedical Engineering, Case Western Reserve Univ, Wickenden 427, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Am J Physiol Heart Circ Physiol 291:H2515-21. 2006
    ....
  25. pmc Left ventricular form and function revisited: applied translational science to cardiovascular ultrasound imaging
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 20:539-51. 2007
    ..This review examines the structure and function of the left ventricle relative to the potential clinical application of DTI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo...
  26. ncbi Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties
    Matthew J Price
    Division of Cardiology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
    Int J Cardiol 111:231-9. 2006
    ..Since there is no need for immune suppression or clinical expertise, IV infusion of MSCs may expand the potential clinical application of stem cell therapy...
  27. ncbi Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay
    D A Kass
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 99:1567-73. 1999
    ....
  28. ncbi Role of imaging in cardiac stem cell therapy
    Saskia L M A Beeres
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 49:1137-48. 2007
    ..In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability.
  29. ncbi The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis
    Robert J Burns
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Am Coll Cardiol 39:30-6. 2002
    ....
  30. ncbi Injection of adeno-associated viral vector encoding vascular endothelial growth factor gene in infarcted swine myocardium: MR measurements of left ventricular function and strain
    Alexis Jacquier
    Department of Radiology, University of California San Francisco, 513 Parnassus Ave, HSW 207 B, San Francisco, CA 94134 0628, USA
    Radiology 245:196-205. 2007
    ....
  31. doi Acute hemodynamic effects of cardiac resynchronization therapy in patients with poor left ventricular function during cardiac surgery
    Mohamed A Soliman Hamad
    Department of Cardiothoracic Surgery, Catharina Hospital, Eindhoven, The Netherlands
    J Card Surg 24:585-90. 2009
    ..We investigated the acute hemodynamic response using LVdP/dt(max) in patients with depressed LV function and conduction disturbances undergoing cardiac surgery...
  32. ncbi Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study
    S R Ommen
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 102:1788-94. 2000
    ..However, accurate prediction of filling pressures for an individual patient requires a stepwise approach incorporating all available data...
  33. ncbi Direct comparison of magnetic resonance imaging and conductance microcatheter in the evaluation of left ventricular function in mice
    Christoph Jacoby
    Department of Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Basic Res Cardiol 101:87-95. 2006
    ..In summary, our data demonstrate that absolute volumetric values are strikingly underestimated by conduction catheter measurements and that even detection of directional changes with this method may not always be feasible...
  34. ncbi Evaluation of left ventricular function in anesthetized patients using femoral artery dP/dt(max)
    Stefan G De Hert
    Department of Anesthesiology, University Hospital Antwerp, Edegem, Belgium
    J Cardiothorac Vasc Anesth 20:325-30. 2006
    ..The purpose of this study was to compare dP/dt(max) estimated from a femoral artery pressure tracing to left ventricular (LV) dP/dt(max) during various alterations in myocardial loading and contractile function...
  35. ncbi Minimized extracorporeal circulation in coronary artery bypass surgery is equivalent to standard extracorporeal circulation in patients with reduced left ventricular function
    T Puehler
    Department of Cardiothoracic Surgery, Medical Center University Regensburg, Regensburg, Germany
    Thorac Cardiovasc Surg 58:204-9. 2010
    ..We analyzed the clinical outcome of patients with reduced left ventricular function who underwent coronary artery bypass surgery with MECC or with standard ECC.
  36. ncbi Effects of sex, gonadectomy, and oestrogen substitution on ischaemic preconditioning and ischaemia-reperfusion injury in mice
    X Song
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockhom, Sweden
    Acta Physiol Scand 177:459-66. 2003
    ..Ischaemic preconditioning (IPC) has been demonstrated to protect heart function and viability, but has been predominantly studied in male animals...
  37. pmc Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy
    Kenneth C Bilchick
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    JACC Cardiovasc Imaging 1:561-8. 2008
    ....
  38. ncbi The late consequences of anthracycline treatment on left ventricular function after treatment for childhood cancer
    Lubomir Elbl
    Department of Cardiopulmonary Testing, Faculty Hospital of Masaryk University, Jihlavska 20, 625 00 Brno, Czech Republic
    Eur J Pediatr 162:690-6. 2003
    The purpose of this study was to determine the incidence of changes in left ventricular function in patients in long-term remission after treatment with anthracyclines for a childhood malignancy...
  39. pmc Left ventricular function and C-reactive protein levels in acute myocardial infarction
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Cardiol 105:917-21. 2010
    ..This suggests that inflammation is related to the ventricular remodeling processes, independently of LV systolic function...
  40. ncbi Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial
    Gerd P Meyer
    Department of Cardiology, Hannover Medical School, Hannover, Germany
    Circulation 113:1287-94. 2006
    ..The critical question of whether BMC transfer can have a sustained impact on LV function remains unanswered...
  41. ncbi Quantitative evaluation of regional left ventricular function using three-dimensional speckle tracking echocardiography in patients with and without heart disease
    Francesco Maffessanti
    University of Chicago, Chicago, Illinois, USA
    Am J Cardiol 104:1755-62. 2009
    ..2D) speckle tracking echocardiography has been shown to be useful in the assessment of regional left ventricular function, it is limited by the assumption that speckles can be tracked frame-to-frame within the imaging plane, ..
  42. ncbi Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model
    Alexander Schuh
    IZKF BIOMAT, Aachen, Germany
    Basic Res Cardiol 103:69-77. 2008
    ..of human endothelial progenitor cells (EPCs) and stromal-cell derived factor-1alpha (SDF-1alpha) on left ventricular function in a chronic setting after myocardial infarction in cyclosporine treated rats...
  43. ncbi Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction
    Beatriz Pelacho
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Tissue Eng Regen Med 1:51-9. 2007
    ....
  44. ncbi Impact of acute myocardial edema on left ventricular function
    Uwe M Fischer
    Center for Microvascular and Lymphatic Studies, Department of Anesthesiology, University of Texas Medical School, Houston, Texas, USA
    J Invest Surg 19:31-8. 2006
    ..3% to 77.7 +/- 0.3% (p < .05). PRSW and dP/dt(max) did not decrease in either group. Diastolic parameters did not change significantly. We conclude that acute myocardial edema without myocardial injury does not impair LV function...
  45. doi Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice
    Fadi N Salloum
    Division of Cardiology, Department of Internal, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 294:H1398-406. 2008
    ..05). Sildenafil attenuates ischemic cardiomyopathy in mice by limiting necrosis and apoptosis and by preserving left ventricular function possibly through a nitric oxide-dependent pathway.
  46. doi Olmesartan improves left ventricular function in pressure-overload hypertrophied rat heart by blocking angiotensin II receptor with synergic effects of upregulation of angiotensin converting enzyme 2
    - Kaiqiang Ji
    Department of Thoracic and Cardiovascular Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Adv Cardiovasc Dis 3:103-11. 2009
    ..2 mg/kg per day) was administered subcutaneously by osmotic minipumps (Olm groups). Left ventricular function was measured by Langendorff perfusion...
  47. doi Impact of different pacing modes on left ventricular function following cardiopulmonary bypass
    O Dzemali
    Department for Cardiothoracic Surgery, J W Goethe University Hospital, Frankfurt am Main, Germany
    Thorac Cardiovasc Surg 56:87-92. 2008
    ..This prospective study investigates hemodynamic effects and outcomes of perioperative temporary biventricular pacing in patients with heart failure undergoing heart surgery...
  48. ncbi [Effects of autologous bone marrow derived CD34+ stem cells on the left ventricular function following myocardial infarction]
    László Balogh
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Altalános Orvostudományi Kar Kardiológiai Intézet, Debrecen Pf 1 4004
    Orv Hetil 148:243-9. 2007
    ..8 patients with impaired left ventricular function were transplanted with CD34+ bone marrow stem cells 12 +/- 1 day after the acute coronary event...
  49. ncbi Assessment of left ventricular function by cardiac ultrasound
    James D Thomas
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 48:2012-25. 2006
    ..This review also discusses the clinical impact of echocardiography and its future directions and developments...
  50. ncbi Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium
    Hung Fat Tse
    Division of Cardiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    Eur J Heart Fail 9:747-53. 2007
    ..To determine the optimal bone marrow (BM) cell types, and their potential mechanisms of action for neovascularization in chronic ischaemic myocardium...
  51. ncbi Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 110:1933-9. 2004
    ....
  52. pmc Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy
    S F Nagueh
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX, USA
    Circulation 104:128-30. 2001
    ..We tested whether humans with FHCM also consistently showed reduced myocardial TD velocities, irrespective of LVH...
  53. ncbi Ventricular pacing lead location alters systemic hemodynamics and left ventricular function in patients with and without reduced ejection fraction
    Randy Lieberman
    Department of Cardiology, Harper University Hospital, Detroit, Michigan 48201, USA
    J Am Coll Cardiol 48:1634-41. 2006
    ..We compared left ventricular (LV) systolic and diastolic function during right ventricular (RV), LV, and biventricular (BiV) pacing in patients with narrow QRS duration with and without LV dysfunction...
  54. ncbi Global left ventricular function in cardiac CT. Evaluation of an automated 3D region-growing segmentation algorithm
    Georg Mühlenbruch
    Department of Diagnostic Radiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Eur Radiol 16:1117-23. 2006
    ..2%. On the basis of a good contrast-enhanced data set, a left ventricular volume analysis using the new semi-automated region-growing segmentation algorithm is technically feasible, accurate and more time-effective...
  55. doi Echocardiographic assessment of global left ventricular function in mice
    Jörg Stypmann
    Department of Cardiology and Angiology, Hospital of the University of Münster, Albert Schweitzer Str 33, D 48149 Munster, Germany
    Lab Anim 43:127-37. 2009
    ....
  56. pmc Improved Stratification of Autonomic Regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISAR-Risk)
    Axel Bauer
    Medizinische Klinik und Deutsches Herzzentrum München der Technischen Universität München, Munchen, Germany
    Eur Heart J 30:576-83. 2009
    ..To investigate the combination of heart rate turbulence (HRT) and deceleration capacity (DC) as risk predictors in post-infarction patients with left ventricular ejection fraction (LVEF) > 30%...
  57. ncbi Investigating myocardial motion by MRI using tissue phase mapping
    Bernd Jung
    Department of Diagnostic Radiology, Medical Physics, University Hospital, Freiburg University, Hugstetterstr 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 29:S150-7. 2006
    ..In contrast to other imaging modalities such as echocardiography left ventricular performance can be assessed without limited anatomical or functional coverage...
  58. ncbi Transit of blood flow through the human left ventricle mapped by cardiovascular magnetic resonance
    Ann F Bolger
    Department of Medicine, University of California, San Francisco, California 94110, USA
    J Cardiovasc Magn Reson 9:741-7. 2007
    ..Quantification of the components of multidirectional flow in the normal left ventricle (LV) is lacking, making it difficult to put the changes observed with LV dysfunction and cardiac surgery into context...
  59. pmc Cardiac involvement in patients with Becker muscular dystrophy: new diagnostic and pathophysiological insights by a CMR approach
    Ali Yilmaz
    Division of Cardiology, Robert Bosch Krankenhaus, Stuttgart, Germany
    J Cardiovasc Magn Reson 10:50. 2008
    ..Cardiovascular magnetic resonance (CMR) has the potential to detect cardiac involvement by depicting early scar formation that may appear before onset of wall motion abnormalities...
  60. pmc Dramatic reversal of derangements in muscle metabolism and left ventricular function after bariatric surgery
    Joshua G Leichman
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Am J Med 121:966-73. 2008
    ..The study objective was to define muscle metabolic and cardiovascular changes after surgical intervention in clinically severe obese patients...
  61. pmc Optimal vortex formation as an index of cardiac health
    Morteza Gharib
    Graduate Aeronautical Laboratories and Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:6305-8. 2006
    ..A study of normal and pathological cardiac health in human subjects demonstrates the ability of this global index to distinguish disease states by a straightforward analysis of noninvasive LV measurements...
  62. ncbi Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea
    Yasuyuki Kaneko
    Sleep Research Laboratories, Toronto Rehabilitation Institute, Toronto General Hospital, ON M5G 2C4, Canada
    N Engl J Med 348:1233-41. 2003
    ..We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function...
  63. ncbi Natriuretic peptides as markers of cardiotoxicity during doxorubicin treatment for non-Hodgkin's lymphoma
    T Nousiainen
    Department of Medicine, Kuopio University Hospital and University of Kuopio, Finland
    Eur J Haematol 62:135-41. 1999
    ..that neuroendocrine activation - increased concentrations of plasma natriuretic peptides - occurs when left ventricular function has reduced substantially and its compensatory capacity has been exceeded resulting in atrial and ..
  64. doi The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model
    Jiashing Yu
    University of California Berkeley and University of California San Francisco Joint Bioengineering Graduate Group, Berkeley San Francisco, CA, United States
    Biomaterials 30:751-6. 2009
    ..These results suggest that in situ use of modified polymers may influence the tissue microenvironment and serve as a potential therapeutic agent for patients with chronic heart failure...
  65. ncbi Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model
    Siamak Davani
    Laboratoire de Pharmacologie, Faculte de Medecine, 25000 Besancon, France
    Circulation 108:II253-8. 2003
    ..The differentiation pathways of engrafted mesenchymal progenitor cells (MPCs) and their effects on the left ventricular function in a rat myocardial infarct heart model were analyzed.
  66. ncbi Transplantation of human umbilical vein endothelial cells improves left ventricular function in a rat model of myocardial infarction
    Marc W Merx
    Medizinische Klinik I, Universitatsklinikum Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    Basic Res Cardiol 100:208-16. 2005
    ..Since human umbilical vein endothelial cells (HUVEC) harbor the potential for transdifferentiation, we studied the functional effects of HUVEC transplantation in a rat model of MI...
  67. ncbi Myocardial strain and torsion quantified by cardiovascular magnetic resonance tissue tagging: studies in normal and impaired left ventricular function
    Marco J W Götte
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:2002-11. 2006
    ..This review discusses the clinical use of cardiovascular magnetic resonance tissue tagging for quantitative assessment of regional myocardial function, thereby underlining the specific features and emerging role of this technique...
  68. ncbi Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
    Sandra M Swain
    National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20889, USA
    Cancer 97:2869-79. 2003
    ....
  69. ncbi Determination of normal regional left ventricular function from cine-MR images using a semi-automated edge detection method
    G D Waiter
    Department of Bio Medical Physics and Bio Engineering, University of Aberdeen, Foresterhill, UK
    Magn Reson Imaging 17:99-107. 1999
    ..The method described, for the delineation of the borders, reduces considerably the long and tedious operator time inherent in manual measurement and greatly increases the reproducibility of the measurements...
  70. ncbi Single-beat estimation of end-systolic elastance using bilinearly approximated time-varying elastance curve
    T Shishido
    Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan
    Circulation 102:1983-9. 2000
    ....
  71. ncbi Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators
    M R Bristow
    Division of Cardiology, University of Colorado HSC, Denver 80262, USA
    Circulation 94:2807-16. 1996
    ..We conducted a multicenter, placebo-controlled trial designed to establish the efficacy and safety of carvedilol, a "third-generation" beta -blocking agent with vasodilator properties, in chronic heart failure...
  72. ncbi Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function
    Sandra Erbs
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Leipzig, Germany
    Circ Heart Fail 3:486-94. 2010
    ....
  73. ncbi Effects of trimetazidine on left ventricular function in patients with type 2 diabetes and heart failure
    Inga S Thrainsdottir
    Department of Cardiology, Karolinska Hospital, Stockholm, Sweden
    J Cardiovasc Pharmacol 44:101-8. 2004
    ..Trimetazidine, a metabolic agent with anti-ischemic properties, reduces fatty acid beta-oxidation via decreased 3-ketoacyl-coenzyme-A thiolase activity thereby facilitating energy production via the glycolytic pathway...
  74. ncbi Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluation
    Daniel Kim
    Department of Radiology, University of Virginia Health System, Rm 1175, MR 4 Bldg, 409 Lane Rd, Charlottesville, VA 22908, USA
    Radiology 230:862-71. 2004
    ..7 x 2.7 mm and 60 msec, respectively. E(cc) measured at cine DENSE MR imaging correlated well with that measured at conventional MR imaging tagging (slope = 0.88, intercept = 0.00, R = 0.87)...
  75. ncbi Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart
    Daniel J Stuckey
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    NMR Biomed 21:765-72. 2008
    ..The accuracy of cine-MRI allows identification of alterations in heart function that may be missed when using 2D-echo...
  76. ncbi Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy
    Denis Duboc
    French Working Group of Heart Involvement in Myopathies Investigators, Paris, France
    J Am Coll Cardiol 45:855-7. 2005
    ..The aim of this research was to examine the effects of perindopril on cardiac function in patients with Duchenne muscular dystrophy (DMD)...
  77. ncbi Quantitative assessment of left ventricular function with dual-source CT in comparison to cardiac magnetic resonance imaging: initial findings
    S Busch
    Department of Clinical Radiology, University of Munich, Marchioninistr 15, 81377, Munich, Germany
    Eur Radiol 18:570-5. 2008
    ..85 for EDV, ESV and EF. DSCT offers the possibility to quantify left ventricular function from coronary CT angiography datasets with sufficient diagnostic accuracy, adding to the value of the ..
  78. ncbi Operator induced variability in left ventricular measurements with cardiovascular magnetic resonance is improved after training
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK
    J Cardiovasc Magn Reson 9:777-83. 2007
    ..The aim of the study was to assess the interobserver variability of the manual planimetry of LV contours amongst two experienced and six inexperienced operators before and after a two months training period...
  79. ncbi Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging
    Jurgen Scharhag
    Institute of Sports and Preventive Medicine, University of Saarland, Campus, Building 39 1, 66123 Saarbrucken, Germany
    J Am Coll Cardiol 40:1856-63. 2002
    ..Athlete's heart represents a structural and functional adaptation to regular endurance exercise...
  80. ncbi Total right ventricular exclusion improves left ventricular function in patients with end-stage congestive right ventricular failure
    Masami Takagaki
    Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, Okayama, 700 8558, Japan
    Circulation 108:II226-9. 2003
    ..The objective of the present study was to elucidate the effects of a complete removal of RV volume overload (RVVO) on the surgically created single left ventricle (LV)...
  81. ncbi Postexercise left ventricular function and cTnT in recreational marathon runners
    Keith George
    Research Institute for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores University, Liverpool, United Kingdom
    Med Sci Sports Exerc 36:1709-15. 2004
    ..To assess the impact of prolonged exercise on left ventricular (LV) function and the appearance of cardiac troponin T (cTnT) in older and recreational athletes...
  82. ncbi Measurement of myocardial mechanics in mice before and after infarction using multislice displacement-encoded MRI with 3D motion encoding
    Wesley D Gilson
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 288:H1491-7. 2005
    ..07 +/- 0.54 degrees /mm (R = 0.96, P < 0.05). DENSE MRI can assess the 3D myocardial mechanics of the murine heart in <1 h of scan time at 4.7 T and may be applied to studies of myocardial mechanics in genetically engineered mice...
  83. ncbi The relationship between left ventricular function assessed by multigated radionuclide test and cardiopulmonary exercise test in patients with ischemic heart disease
    Eliezer Klainman
    Institute of Pulmonary Medicine, Exercise Physiology Unit, Rabin Medical Center, Beilinson Campus, Petah Tiqva
    Chest 121:841-5. 2002
    ....
  84. ncbi Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography
    Cheuk Man Yu
    Division of Cardiology, S H Ho Cardiovascular and Stroke Centre, Institute of Vascular Medicine, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Am Coll Cardiol 48:2251-7. 2006
    ..This study was designed to evaluate the role of cardiac resynchronization therapy (CRT) in heart failure (HF) patients with narrow QRS complexes (<120 ms) and echocardiographic evidence of mechanical asynchrony...
  85. ncbi Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart
    Theofilos M Kolettis
    Department of Cardiology, University of Ioannina, Ioannina, Greece
    J Pharm Pharmacol 62:346-51. 2010
    ..We have explored the effects of two acute and one chronic administration regimen on left ventricular function.
  86. ncbi Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischemic heart disease
    Toru Miyoshi
    Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Atheroscler Thromb 17:249-58. 2010
    ..We investigated the association of the CAVI with coronary atherosclerosis and left ventricular (LV) systolic and diastolic function in patients with ischemic heart disease (IHD)...
  87. doi Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and meta-analysis for randomized controlled trials
    Sheng Kang
    Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Coron Artery Dis 19:327-35. 2008
    ..suggested that intracoronary infusion of bone marrow-derived stem/progenitor cells (BMC) may improve left ventricular function after acute myocardial infarction (AMI)...
  88. ncbi Cardiac cell therapy--mixed results from mixed cells
    Anthony Rosenzweig
    N Engl J Med 355:1274-7. 2006
  89. ncbi Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling
    Antonio Abbate
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    J Cell Physiol 193:145-53. 2002
    ....
  90. ncbi Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction
    Monique C de Waard
    Experimental Cardiology, Dept of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands
    J Appl Physiol (1985) 107:928-36. 2009
    ..These findings suggest that even when regular physical activity fails to prevent an acute MI, it can still act to improve cardiac function and survival after MI...
  91. ncbi The impact of metabolic syndrome on left ventricular function: evaluated by using the index of myocardial performance
    Hasan Turhan
    Department of Cardiology, Inonu University Faculty of Medicine, Malatya Turkey
    Int J Cardiol 132:382-6. 2009
    To evaluate the impact of metabolic syndrome on global left ventricular function by using the index of myocardial performance.
  92. ncbi Surrogate end points in heart failure
    Inder S Anand
    University of Minnesota Medical School and Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    J Am Coll Cardiol 39:1414-21. 2002
    ..Other uses of possible surrogates are discussed, and the limitations in finding true surrogates are mentioned. At this time we conclude there is no well established surrogate in HF...
  93. ncbi Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial
    R Hambrecht
    Klinik für Innere Medizin Kardiologie, Universitat Leipzig, Herzzentrum GmbH, Russenstrasse 19, 04289 Leipzig, Germany
    JAMA 283:3095-101. 2000
    ..Exercise training in patients with chronic heart failure improves work capacity by enhancing endothelial function and skeletal muscle aerobic metabolism, but effects on central hemodynamic function are not well established...
  94. doi Improved left ventricular function after transplantation of microspheres and fibroblasts in a rat model of myocardial infarction
    Alexander Schuh
    Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Basic Res Cardiol 104:403-11. 2009
    ..Eight weeks after intramyocardial application of fibroblasts and microspheres, left ventricular function was significantly improved as demonstrated by isolated heart studies (Langendorff) and echocardiographic ..
  95. ncbi Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 110:3674-9. 2004
    ..We investigated the effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF)...
  96. ncbi Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel
    Sharon L Hale
    The Heart Institute, Good Samaritan Hospital, 1225 Wilshire Blvd, and the Keck School of Medicine, Division of Cardiovascular Medicine, University of Southern California, Los Angeles, CA 90017, USA
    J Pharmacol Exp Ther 318:418-23. 2006
    ..Ranolazine treatment led to better ejection fraction, stroke volume and less wall motion abnormality after reperfusion, and less myocardial necrosis...
  97. ncbi A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion
    Peipei Wang
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, AL 35294 0005, USA
    J Pharmacol Exp Ther 321:213-20. 2007
    ....
  98. ncbi Left ventricular isovolumic flow sequence during sinus and paced rhythms: new insights from use of high-resolution Doppler and ultrasonic digital particle imaging velocimetry
    Partho P Sengupta
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 49:899-908. 2007
    ..We sought to clarify the role of isovolumic intervals during a cardiac cycle by in vivo visualization of left ventricular (LV) intracavitary flow dynamics...
  99. ncbi Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting
    George G Sokos
    Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
    Am J Cardiol 100:824-9. 2007
    ..Twenty patients with coronary heart disease and preserved left ventricular function who were scheduled to undergo CABG were randomized to receive standard therapy at the discretion of the ..
  100. ncbi Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York Heart Failure Registry
    Marc Klapholz
    Saint Vincent Catholic Medical Centers, New York, New York, USA
    J Am Coll Cardiol 43:1432-8. 2004
    ....
  101. doi Diastolic abnormalities as the first feature of hypertrophic cardiomyopathy in Dutch myosin-binding protein C founder mutations
    Michelle Michels
    Department of Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, The Netherlands
    JACC Cardiovasc Imaging 2:58-64. 2009
    ....

Research Grants77

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2010
    ..under investigation include: 1) Deferoxamine (DFO) and deferiprone (L1) combination therapy improves left ventricular function more rapidly than DFO/placebo therapy among transfusion dependent beta-thalassemia patients with ..
  2. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2009
    ..under investigation include: 1) Deferoxamine (DFO) and deferiprone (L1) combination therapy improves left ventricular function more rapidly than DFO/placebo therapy among transfusion dependent beta-thalassemia patients with ..
  3. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2007
    ..under investigation include: 1) Deferoxamine (DFO) and deferiprone (L1) combination therapy improves left ventricular function more rapidly than DFO/placebo therapy among transfusion dependent beta-thalassemia patients with ..
  4. CELLULAR EFFECTS OF ANESTHETICS IN THE HEART
    Zeljko Bosnjak; Fiscal Year: 1991
    ..coronary (RC) and left coronary (LC) control mechanisms will be related to differences in right and left ventricular function. The investigation will define: 1) mechanisms which regulate RC blood flow, and will define ..
  5. MECHANISMS IN CARDIAC PERFORMANCE
    WILLARD DAGGETT; Fiscal Year: 1990
    ..Preservation will be assessed by left ventricular function curves (right heart bypass) and by myocardial biopsies for purine content, including creatine phosphate, ..
  6. Myocardial Effects of Erythropoietin During Resuscitation from Cardiac Arrest
    RAUL JAIME GAZMURI; Fiscal Year: 2011
    ..function enabling preservation of left ventricular compli- ance during VF and preservation of left ventricular function after return of spontaneous circulation, (2) whether these effects are mediated through activation and ..
  7. Surgical Intramyocardial Angiogenesis in a Model of Endothelial Dysfunction
    Frank W Sellke; Fiscal Year: 2010
    ..factor (VEGF) and fibroblast growth factor-2 (FGF-2), in inducing improvements in myocardial flow and left ventricular function in a large animal model of chronic myocardial ischemia...
  8. Surgical Intramyocardial Angiogenesis in a Swine Model of Endothelial Dysfunction
    Frank Sellke; Fiscal Year: 2009
    ..factor (VEGF) and fibroblast growth factor-2 (FGF-2), in inducing improvements in myocardial flow and left ventricular function in a large animal model of chronic myocardial ischemia...
  9. ADENOSINE AND ENDOTHELIN IN MYOCARDIAL REPERFUSION
    John Murray; Fiscal Year: 1993
    ..means has been conclusively shown to reduce cardiac mortality, less striking beneficial effects on left ventricular function and infarct size reduction have been demonstrated...
  10. The Comparative Effectiveness of Single versus Dual Chamber Cardioverter Defibril
    Pamela N Peterson; Fiscal Year: 2010
    ..defibrillators (ICDs) for the primary prevention of sudden cardiac death in patients with HF and reduced left ventricular function has increased...
  11. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2000
    ..ventricular function and a conductance catheter and Miller micromanometer pressure catheter to measure left ventricular function continuously. The data will be analyzed using repeated measures multivariate analysis of variance...
  12. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 1999
    ..ventricular function and a conductance catheter and Miller micromanometer pressure catheter to measure left ventricular function continuously. The data will be analyzed using repeated measures multivariate analysis of variance...
  13. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    ..ventricular function and a conductance catheter and Miller micromanometer pressure catheter to measure left ventricular function continuously. The data will be analyzed using repeated measures multivariate analysis of variance...
  14. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2001
    ..ventricular function and a conductance catheter and Miller micromanometer pressure catheter to measure left ventricular function continuously. The data will be analyzed using repeated measures multivariate analysis of variance...
  15. BYPASS ANGIOPLASTY REVASCULARIZATION INVESTIGATION
    Bernard Chaitman; Fiscal Year: 1990
    ..revascularization therapy to assess degree of revascularization, restenosis rates, graft patency, and left ventricular function, unless the patient develops recurrent symptoms mandating earlier restudy...
  16. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 1999
    ..3) to determine whether exercise-training can (a) induce regression or reduction of LVH, (b) improve left ventricular function, and (c) reduce arterial stiffness; and (4) to determine whether the training-induced decrease in BP is ..
  17. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 2000
    ..3) to determine whether exercise-training can (a) induce regression or reduction of LVH, (b) improve left ventricular function, and (c) reduce arterial stiffness; and (4) to determine whether the training-induced decrease in BP is ..
  18. Cardioprotective Actions of Hydrogen Sulfide
    DAVID JOSEPH LEFER; Fiscal Year: 2010
    ..clearly demonstrate that physiological levels of H2S significantly ameliorate MI-R injury and preserve left ventricular function. Preliminary data also indicate that H2S therapy triggers both "early" and "late" myocardial ..
  19. Cardioprotective Actions of Hydrogen Sulfide
    David Lefer; Fiscal Year: 2009
    ..clearly demonstrate that physiological levels of H2S significantly ameliorate MI-R injury and preserve left ventricular function. Preliminary data also indicate that H2S therapy triggers both "early" and "late" myocardial ..
  20. TREATMENT OF FUNCTIONAL IMPAIRMENT IN PATIENTS WITH HEART FAILURE AND COMORBID DE
    Kenneth E Freedland; Fiscal Year: 2010
    ..evaluation will assess depression, HF self-care, and quality of life, as well as medical history, left ventricular function via echocardiography, biomarkers including BNP and CRP, 6-minute walk test performance, physical ..
  21. TREATMENT OF FUNCTIONAL IMPAIRMENT IN PATIENTS WITH HEART FAILURE AND COMORBID DE
    Kenneth Freedland; Fiscal Year: 2009
    ..evaluation will assess depression, HF self-care, and quality of life, as well as medical history, left ventricular function via echocardiography, biomarkers including BNP and CRP, 6-minute walk test performance, physical ..
  22. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  23. MEDIATORS OF SOCIAL SUPPORT IN CORONARY DISEASE
    Daniel Mark; Fiscal Year: 1992
    ..catheterization (Group A) and in a subgroup of medically treated patients with severe CAD and/or poor left ventricular function with an expected greater than or equal to 25% two year "hard' cardiac event rate (death or nonfatal MI) (..
  24. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2005
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  25. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2004
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  26. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2003
    Although cell transplant therapy has shown some promise in restoring tissue mass and improving left ventricular function after experimental myocardial infarction, the two major obstacles that must be overcome are 1) having an available ..
  27. PREVENTION OF CARDIAC EVENTS WITH ACE INHIBITORS
    Pamela Ouyang; Fiscal Year: 2000
    ..The results of the previous randomized, placebo-controlled studies in patients with impaired left ventricular function (SOLVD and SAVE trials) demonstrated that the long-term use of ACE inhibitor therapy in patients with ..
  28. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..that can identify patients with increased ACE, prospectively, before the transition to replacement fibrosis and remodeling occurs, may result in preserved left ventricular function thereby improving overall prognosis.
  29. METABOLIC CONTROL OF CARDIAC OUTPUT
    Chang Seng Liang; Fiscal Year: 1980
    ..In addition, changes in baroreceptor sensitivity and left ventricular function will be studied during chronic thiamine deficiency...
  30. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2003
    ..infarction will be used to assess the ability of this biologic pump approach to improve hemodynamics and left ventricular function via an afterload-reducing mechanism...
  31. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..infarction will be used to assess the ability of this biologic pump approach to improve hemodynamics and left ventricular function via an afterload-reducing mechanism...
  32. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2002
    ..infarction will be used to assess the ability of this biologic pump approach to improve hemodynamics and left ventricular function via an afterload-reducing mechanism...
  33. QUANTITATIVE VENTRICULOGRAPHY USING DUAL-ENERGY DSA
    MICHAEL VAN LYSEL; Fiscal Year: 1990
    ..technique to patients with cardiac disease, and quantitatively assess both global and regional left ventricular function during rest and exercise...
  34. Cord Blood: Treatment for Acute Myocardial Infarction
    William Marshall; Fiscal Year: 2005
    ..stem cells (hUCBC) has been shown to be effective in limiting infarct size and in the preservation of left ventricular function and anatomy in a rat model...
  35. Cell Therapy for Improving Cardiac Function
    David X Zhao; Fiscal Year: 2011
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease...
  36. Cell Therapy for Improving Cardiac Function
    Douglas Vaughan; Fiscal Year: 2007
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease...
  37. Cell Therapy for Improving Cardiac Function
    David X Zhao; Fiscal Year: 2010
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease...
  38. Cell Therapy for Improving Cardiac Function
    David Zhao; Fiscal Year: 2009
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease...
  39. Cell Therapy for Improving Cardiac Function
    David X Zhao; Fiscal Year: 2011
    ..A majority of patients with HF have poor left ventricular function, with 60-70% due to chronic ischemic coronary disease...
  40. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2003
    ..changes in ventricular-vascular coupling (Ea/Ees relationship) in these patients to six-month changes in left ventricular function and to clinical outcomes...
  41. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2001
    ..changes in ventricular-vascular coupling (Ea/Ees relationship) in these patients to six-month changes in left ventricular function and to clinical outcomes...
  42. DATA COORDINATING CENTER FOR TRIAL OF EP-GUIDED THERAPY
    Kerry Lee; Fiscal Year: 1991
    ..The study will enroll approximately 3,000 patients with chronic coronary artery disease, diminished left ventricular function, and asymptomatic non-sustained VT...
  43. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2002
    ..changes in ventricular-vascular coupling (Ea/Ees relationship) in these patients to six-month changes in left ventricular function and to clinical outcomes...
  44. VASCULAR INTERACTION WITH AGE IN MYOCARDIAL INFARCTION
    Steven Schulman; Fiscal Year: 2004
    ..changes in ventricular-vascular coupling (Ea/Ees relationship) in these patients to six-month changes in left ventricular function and to clinical outcomes...
  45. SCOR IN CORONARY AND VASCULAR DISEASES
    John Ross; Fiscal Year: 1990
    ..Studies on adaptive responses will include mechanisms involved in the recovery of left ventricular function after experimental coronary occlusion and reperfusion, in particular the role of stunning and subsequent ..
  46. Mechanisms Mediating Hypotension to Anthrax Lethal Toxin
    Michael J Kenney; Fiscal Year: 2010
    ..An integrative and multifaceted experimental approach involving sympathetic nerve, cardiac output, left ventricular function, alpha-adrenergic vasoconstrictor, endothelium-dependent and -independent vasodilation, and regional ..
  47. Mechanisms Mediating Hypotension to Anthrax Lethal Toxin
    MICHAEL KENNEY; Fiscal Year: 2009
    ..An integrative and multifaceted experimental approach involving sympathetic nerve, cardiac output, left ventricular function, alpha-adrenergic vasoconstrictor, endothelium-dependent and -independent vasodilation, and regional ..
  48. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2010
    ..These primary myoblasts have demonstrated engraftment and improvement in left ventricular function but with adverse event of arrhythmia...
  49. FUNCTIONAL AND TARGETING POLYMERIC GENE CARRIERS
    Sung Wan Kim; Fiscal Year: 2009
    ..These primary myoblasts have demonstrated engraftment and improvement in left ventricular function but with adverse event of arrhythmia...
  50. Northeast Ohio Center for Cardiovascular Cell Therapy Research
    Stephen Ellis; Fiscal Year: 2007
    ..Transplantation of stem cells improves left ventricular function (LVEF) in animal models of acute myocardial infarction (AMI) and CHF...
  51. PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study
    Christine Albert; Fiscal Year: 2009
    ..unique prospective cohort of patients who do not presently have an indication for ICD therapy based upon left ventricular function. The additional support from the NHLBI will provide a unique and timely opportunity to take advantage of ..
  52. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2007
    ..Although, current therapies improve left ventricular function, right heart pathologies are not effectively treated...
  53. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..Although, current therapies improve left ventricular function, right heart pathologies are not effectively treated...
  54. PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study
    Alan H Kadish; Fiscal Year: 2010
    ..unique prospective cohort of patients who do not presently have an indication for ICD therapy based upon left ventricular function. The additional support from the NHLBI will provide a unique and timely opportunity to take advantage of ..
  55. EXERCISE EFFECTS ON LEFT VENTRICULAR FUNCTION IN CONGESTIVE HEART FAILURE
    JOHN NICKLAS; Fiscal Year: 1999
    ..The NT group will not be given an exercise prescription no follow up. ..
  56. Clinical trials of local percutaneous delivery of bFGF in CAD
    Roger Laham; Fiscal Year: 2000
    ..We will investigate the effects of bFGF treatment on clinical parameters, left ventricular function, coronary angiography, and on the size and extent of myocardial ischemia using stress nuclear perfusion ..
  57. Clinical trials of local percutaneous delivery of bFGF in CAD
    Roger Laham; Fiscal Year: 2001
    ..We will investigate the effects of bFGF treatment on clinical parameters, left ventricular function, coronary angiography, and on the size and extent of myocardial ischemia using stress nuclear perfusion ..
  58. Clinical trials of local percutaneous delivery of bFGF in CAD
    Roger Laham; Fiscal Year: 2001
    ..We will investigate the effects of bFGF treatment on clinical parameters, left ventricular function, coronary angiography, and on the size and extent of myocardial ischemia using stress nuclear perfusion ..
  59. Clinical trials of local percutaneous delivery of bFGF in CAD
    Roger Laham; Fiscal Year: 2002
    ..We will investigate the effects of bFGF treatment on clinical parameters, left ventricular function, coronary angiography, and on the size and extent of myocardial ischemia using stress nuclear perfusion ..
  60. Sustained Coronary Stenosis and Hibernating Myocardium
    RAYMOND KUDEJ; Fiscal Year: 2001
    ..potentially due to up-regulation of NO; and B) Adaptive alterations in systolic and diastolic left ventricular function present distal to the ameroid coronary constrictor in swine and in hibernating woodchuck hearts are ..
  61. Sustained Coronary Stenosis and Hibernating Myocardium
    RAYMOND KUDEJ; Fiscal Year: 2003
    ..potentially due to up-regulation of NO; and B) Adaptive alterations in systolic and diastolic left ventricular function present distal to the ameroid coronary constrictor in swine and in hibernating woodchuck hearts are ..
  62. VENTRICULAR REMODELING IN AGED RATS
    Steven Goldman; Fiscal Year: 1993
    ..hypertrophy of the noninfarcted myocardium results in extensive remodeling and deterioration in left ventricular function." This proposal outlines a novel approach to improving ventricular function by augmenting hypertrophy in ..
  63. SCINTIGRAPHIC DIAGNOSIS OF CORONARY ARTERY DISEASE
    A Nelson; Fiscal Year: 1980
    ..Global and local left ventricular function will be evaluated from radionuclide angiograms by analysis of radioactivity changes from diastole to ..
  64. RIGHT VENTRICULAR DYSFUNCTION AND TREATMENT
    Marc Semigran; Fiscal Year: 1999
    ..While most previous investigations have concentrated on the abnormalities in left ventricular function, there is evidence that right ventricular (RV) function is a more important determinant of patients ..