Summary: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

Top Publications

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  2. pmc Assessment of flow-mediated dilation in humans: a methodological and physiological guideline
    Dick H J Thijssen
    Research Inst for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores Univ, 15 21 Webster St, Liverpool, L3 2ET, UK
    Am J Physiol Heart Circ Physiol 300:H2-12. 2011
  3. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  4. ncbi Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients
    Adam S Greenstein
    Cardiovascular Research Group, University of Manchester, Manchester, United Kingdom
    Circulation 119:1661-70. 2009
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
  6. pmc Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    Matthias Totzeck
    Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
    Circulation 126:325-34. 2012
  7. ncbi Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    V Schachinger
    Department of Internal Medicine IV, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Circulation 101:1899-906. 2000
  8. ncbi Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    Thomas Nystrom
    Dept of Internal Medicine, Stockholm South Hospital, Karolinska Institute, Stockholm SE 118 83, Sweden
    Am J Physiol Endocrinol Metab 287:E1209-15. 2004
  9. pmc Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
  10. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003

Detail Information

Publications393 found, 100 shown here

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed...
  2. pmc Assessment of flow-mediated dilation in humans: a methodological and physiological guideline
    Dick H J Thijssen
    Research Inst for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores Univ, 15 21 Webster St, Liverpool, L3 2ET, UK
    Am J Physiol Heart Circ Physiol 300:H2-12. 2011
    ..The outcome is a series of recommendations on the basis of review and critical appraisal of recent physiological studies, pertaining to the most appropriate methods to assess FMD in humans...
  3. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  4. ncbi Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients
    Adam S Greenstein
    Cardiovascular Research Group, University of Manchester, Manchester, United Kingdom
    Circulation 119:1661-70. 2009
    ..Inflammation in adipose tissue has been implicated in vascular dysfunction, but the local mechanisms by which this occurs are unknown...
  5. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..Here we show that cortical astrocytes in vivo possess a powerful mechanism for rapid vasodilation. We imaged the activity of astrocytes labeled with the calcium (Ca(2+))-sensitive indicator rhod-2 in ..
  6. pmc Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    Matthias Totzeck
    Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
    Circulation 126:325-34. 2012
    Hypoxic vasodilation is a physiological response to low oxygen tension that increases blood supply to match metabolic demands...
  7. ncbi Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    V Schachinger
    Department of Internal Medicine IV, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    Circulation 101:1899-906. 2000
    ..Therefore, we prospectively investigated whether coronary endothelial dysfunction predicts disease progression and cardiovascular event rates...
  8. ncbi Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    Thomas Nystrom
    Dept of Internal Medicine, Stockholm South Hospital, Karolinska Institute, Stockholm SE 118 83, Sweden
    Am J Physiol Endocrinol Metab 287:E1209-15. 2004
    ..This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment...
  9. pmc Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
    ..We assessed the predictive value of FMD for incident CVD events in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  10. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Endothelium-dependent vasodilation is only minimally altered in vessels of mice with DOCA-salt hypertension but seems to be mediated by hydrogen ..
  11. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  12. ncbi Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
    Micaela Zonta
    Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Nat Neurosci 6:43-50. 2003
    ..Inhibition of these Ca(2+) responses resulted in the impairment of activity-dependent vasodilation, whereas selective activation--by patch pipette--of single astrocytes that were in contact with arterioles ..
  13. ncbi Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    Mark T Gladwin
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Am J Physiol Heart Circ Physiol 291:H2026-35. 2006
    ..signaling molecule with potential roles in intravascular endocrine nitric oxide (NO) transport, hypoxic vasodilation, signaling, and cytoprotection after ischemia-reperfusion...
  14. ncbi Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
  15. ncbi Prognostic significance of endothelial dysfunction in hypertensive patients
    F Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Circulation 104:191-6. 2001
    ..Methods and Results-- Endothelium-dependent and -independent vasodilation was investigated in 225 never-treated hypertensive patients (age, 35 to 54 years) by intra-arterial infusion of ..
  16. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
    ..We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events...
  17. ncbi Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 115:2390-7. 2007
    ..We assessed the hypothesis that FMD predicts incident cardiovascular events in a population-based cohort of older adults...
  18. pmc Effect of exercise training on endothelium-derived nitric oxide function in humans
    Daniel J Green
    School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 561:1-25. 2004
  19. ncbi Assessment of atherosclerosis: the role of flow-mediated dilatation
    Marietta Charakida
    Vascular Physiology Unit, Great Ormond Street Hospital for Children, NHS Trust, University College London, 30 Guilford Street, London WC1N 3EH, UK
    Eur Heart J 31:2854-61. 2010
  20. ncbi A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 25:2368-75. 2005
    Three different techniques to evaluate endothelium-dependent vasodilation in the peripheral circulation have been described but not simultaneously tested in a large-scale population-based setting...
  21. pmc Metformin restores endothelial function in aorta of diabetic rats
    Cristina M Sena
    Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Br J Pharmacol 163:424-37. 2011
    ..This study was designed to assess the effect of metformin on impaired endothelial function, oxidative stress, inflammation and advanced glycation end products formation in type 2 diabetes mellitus...
  22. pmc Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
    Jack H Crawford
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Blood 107:566-74. 2006
    Local vasodilation in response to hypoxia is a fundamental physiologic response ensuring oxygen delivery to tissues under metabolic stress. Recent studies identify a role for the red blood cell (RBC), with hemoglobin the hypoxic sensor...
  23. pmc Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
    ..couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles...
  24. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  25. pmc Inhibition of iNOS protects endothelial-dependent vasodilation in aged rats
    Jue Tian
    Department of Physiology, Shanxi Medical University, Taiyuan, China
    Acta Pharmacol Sin 31:1324-8. 2010
    ..To examine whether iNOS contributes to endothelial dysfunction in aged rats...
  26. pmc Determinants of vascular function in patients with type 2 diabetes
    Katerina K Naka
    Michaelidion Cardiac Center, University of Ioannina, Ioannina, Greece
    Cardiovasc Diabetol 11:127. 2012
    ..The aim of our study was to investigate the predictors of vascular dysfunction in T2DM patients...
  27. ncbi Effect of omega-3 fatty acids supplementation on endothelial function: a meta-analysis of randomized controlled trials
    Qianqian Wang
    State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Atherosclerosis 221:536-43. 2012
    ..We conducted a meta-analysis to assess the effect of omega-3 FAs supplementation on endothelial function, as measured by flow-mediated dilation (FMD) and endothelium-independent vasodilation (EIV).
  28. ncbi Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats
    Youqin Cheng
    Dept of Physiology, College of Medicine, Univ of Saskatchewan, 107 Wiggins Rd, Saskatoon, Saskatchewan, Canada S7N 5E5
    Am J Physiol Heart Circ Physiol 287:H2316-23. 2004
    ..Our study also demonstrated that endogenous CSE can generate sufficient H2S from exogenous L-cysteine to cause vasodilation. Future studies are merited to investigate direct contribution of endogenous H2S to regulation of vascular tone.
  29. pmc A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
    Pascal Bernatchez
    Providence Heart and Lung Institute, St Paul s Hospital, James Hogg Research Centre, 1081 Burrard St, Room 166, Vancouver BC Canada, V6Z 1Y6
    J Clin Invest 121:3747-55. 2011
    ..They also suggest a therapeutic application for regulating the eNOS/Cav-1 interaction in diseases characterized by decreased NO release...
  30. pmc Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    O Brouwers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 53:989-1000. 2010
    ..We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal...
  31. ncbi Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
    F J Miller
    Department of Internal Medicine, University of Iowa College of Medicine and Cardiovascular Center, and Veterans Administration Medical Center, Iowa City, USA
    Circ Res 82:1298-305. 1998
    ..Reduction in endothelial O2-. levels is not sufficient to improve endothelium-dependent relaxation. Generation of reactive oxygen species within the media may contribute to vasomotor dysfunction in atherosclerosis...
  32. ncbi Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
    Judy M Muller-Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Am J Physiol Heart Circ Physiol 283:H1662-72. 2002
    ..Flow-induced vasodilation was also evaluated in the absence of pressure changes. Responses to ADO and SNP were not altered by age...
  33. pmc Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea
    Sanja Jelic
    Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy, and Critical Care Medicine, PH8 Center, Room 840, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:2270-8. 2008
    ..The effects of continuous positive airway pressure (CPAP) therapy on endothelial function and repair capacity were assessed...
  34. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
    ..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
  35. ncbi Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    D S Celermajer
    Cardiothoracic Unit, Hospital for Sick Children, London
    Circulation 88:2149-55. 1993
    ..Endothelial dysfunction is an early event in atherogenesis, and we hypothesized that smoking might be associated with endothelial damage in the systemic arteries of otherwise healthy young adults...
  36. ncbi Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB
    Anthony J Donato
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Circ Res 100:1659-66. 2007
    ..Increased expression of NAD(P)H oxidase and nuclear factor-kappaB may contribute to endothelial oxidative stress with aging in humans...
  37. ncbi Endothelial function in obstructive sleep apnea and response to treatment
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 169:348-53. 2004
    ..4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week...
  38. ncbi Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
    ..The aim of this research was to study whether the relation between endothelial function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular risk factors is affected by the baseline cardiovascular risk...
  39. ncbi Endothelial dysfunction in pulmonary hypertension
    Rohit Budhiraja
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 109:159-65. 2004
  40. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
  41. ncbi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009
    ..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
  42. ncbi Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada City, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 393:668-72. 2010
    ..Omentin (1-300 ng/ml) also relaxed NA pre-contracted mesenteric artery. Present study for the first time demonstrated that omentin has a vasodilating effect on isolated blood vessels, which is mediated through endothelium-derived NO...
  43. ncbi Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study
    Emelia J Benjamin
    Evans Department of Medicine, Boston University School of Medicine, Framingham Study, Boston, Mass 01702 5827, USA
    Circulation 109:613-9. 2004
    ..Studies in selected samples have linked impaired endothelial function with cardiovascular disease and its risk factors. The clinical correlates and heritability of endothelial function in the community have not been described...
  44. pmc Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
    Nicholas L Mills
    The BHF University Centre for Cardiovascular Science, Edinburgh University, The Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 32:2660-71. 2011
    ..We assess the role of combustion-derived-nanoparticles in mediating the adverse cardiovascular effects of air pollution...
  45. ncbi gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension
    O Jung
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circulation 109:1795-801. 2004
    ..We hypothesized that the endothelial gp91phox-containing NADPH oxidase is predominant in generating the O2- to scavenge endothelial NO and thus is responsible for the development of endothelial dysfunction...
  46. ncbi Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    C A DeSouza
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Circulation 102:1351-7. 2000
    In sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower age-related risk...
  47. ncbi Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial
    Thomas A B Sanders
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, London, United Kingdom
    Am J Clin Nutr 94:973-80. 2011
    ..The dietary intake of n-3 (omega-3) long-chain PUFAs (LC-PUFAs) from fish may improve endothelial function and arterial stiffness...
  48. pmc Human obesity and endothelium-dependent responsiveness
    Umberto Campia
    Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Br J Pharmacol 165:561-73. 2012
    ..between the NO pathway and the endothelin 1 system, with impaired insulin-stimulated endothelium-dependent vasodilation. Importantly, emerging evidence suggests that the vascular dysfunction of obesity is not just limited to the ..
  49. ncbi Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins
    Thomas D Giles
    Heart and Vascular Institute, Tulane University Medical Center, New Orleans, LA, USA
    J Clin Hypertens (Greenwich) 14:198-205. 2012
    ..Possible pharmacological interventions to restore normal function are suggested...
  50. ncbi Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    Xiao Yu Tian
    Institute of Vascular Medicine, Hong Kong SAR, China
    Circ Res 110:1211-6. 2012
    ..UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear...
  51. ncbi Effects of gliclazide on endothelial function in patients with newly diagnosed type 2 diabetes
    Lu Lu Chen
    Department of Endocrinology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
    Eur J Pharmacol 659:296-301. 2011
    ..Endothelial function was evaluated by flow-mediated vasodilation (FMD) before and after treatment...
  52. ncbi Insulin causes endothelial dysfunction in humans: sites and mechanisms
    Guido Arcaro
    Division of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona Medical School and Azienda Ospedaliera di Verona, Verona, Italy
    Circulation 105:576-82. 2002
    ..Endothelium plays a central role in atherogenesis. The in vivo effects of hyperinsulinemia on endothelial function of large conduit arteries are unknown...
  53. ncbi Flow-mediated vasodilation is impaired in adult rat offspring exposed to prenatal hypoxia
    J S Morton
    Dept of Obstetrics Gynaecology and Physiology, Univ of Alberta, Edmonton, Alberta, Canada
    J Appl Physiol (1985) 110:1073-82. 2011
    ..that IUGR would cause changes in vascular function that would affect the mechanisms of flow-induced vasodilation later in life in an age- or sex-dependent manner...
  54. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  55. ncbi Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis
    Yoichi Inaba
    Division of Cardiovascular Medicine, Oregon Health and Science University, UHN62, Portland, OR 97239, USA
    Int J Cardiovasc Imaging 26:631-40. 2010
    ..We conducted a meta-analysis of observational studies which examined the association between flow-mediated dilatation (FMD) of brachial artery, a noninvasive measure of endothelial function, and future cardiovascular events...
  56. ncbi Physiological roles of K+ channels in vascular smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University
    J Smooth Muscle Res 44:65-81. 2008
    ..Kir channel activation has been shown to raise the extracellular K+ concentration to 10-15 mM, resulting in vasodilation. Each of K+ channels listed above is responsive to a number of vasoconstrictors and vasodilators, which act ..
  57. ncbi Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
    Anthony R Smith
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Aging Cell 5:391-400. 2006
    ..Taken together, these results suggest a novel mechanism that at least partly explains the persistent loss of eNOS activity and endothelial-derived NO availability in aging conduit arteries...
  58. ncbi Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation
    Stephan Spiekermann
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA, USA
    Circulation 107:1383-9. 2003
    ..We therefore characterized the vascular activities of xanthine oxidase and NAD(P)H oxidase, 2 major O2*--producing enzyme systems, and their relationship with flow-dependent, endothelium-mediated vasodilation (FDD) in patients with CAD.
  59. ncbi Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men
    T A Mori
    Department of Medicine, University of Western Australia, and The West Australian Heart Research Institute, Perth, Australia
    Circulation 102:1264-9. 2000
    ..We investigated possible differences in the effects of purified EPA or DHA on forearm vascular reactivity in overweight hyperlipidemic men that might contribute to the blood pressure-lowering effects of fish oils...
  60. ncbi Local potassium signaling couples neuronal activity to vasodilation in the brain
    Jessica A Filosa
    Department of Pharmacology, 89 Beaumont Avenue, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Nat Neurosci 9:1397-1403. 2006 smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations...
  61. ncbi Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation
    J J Zaritsky
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, CA, USA
    Circ Res 87:160-6. 2000
    ..1(-/-) animals did not dilate when the extracellular K(+) concentration was increased to 15 mmol/L. In summary, Kir2.1 gene expression in arterial smooth muscle is required for Kir currents and K(+)-induced dilations in cerebral arteries...
  62. ncbi Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction
    Christopher Torrens
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
    Hypertension 47:982-7. 2006
    ..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function...
  63. ncbi Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women
    Dogan Erdogan
    Baskent University, Faculty of Medicine, Cardiology Department, Konya, Turkey
    Atherosclerosis 184:431-7. 2006
    ..In the present study, FMD and IMT were studied in healthy subjects with lower and higher serum bilirubin concentrations in physiological ranges...
  64. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001
    ..We conclude that cannabinoids elicit profound coronary and cerebral vasodilation in vivo by direct activation of vascular cannabinoid CB(1) receptors, rather than via autoregulation, a ..
  65. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  66. ncbi Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation
    Ann E Donald
    Vascular Physiology Unit, UCL Institute of Child Health, London, United Kingdom
    J Am Coll Cardiol 51:1959-64. 2008
    ..Our aim was to determine reproducibility of the flow-mediated dilation (FMD) response profile, and discriminatory ability of the components...
  67. ncbi Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl/6 mice
    Juha Ketonen
    School of Pharmacy, University of Eastern Finland, Kuopio, Finland
    Circ J 74:1479-87. 2010
    ..Biological substances derived from perivascular fat modulate vascular tone, thus alterations in periadventitial adipose tissue (PVAT) may aggravate endothelial dysfunction in obesity...
  68. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
    ..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine γ-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...
  69. ncbi GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP
    Brian D Green
    Human Nutrition and Health Group, School of Biological Sciences, Queens University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK
    Arch Biochem Biophys 478:136-42. 2008
    ..However, further studies are required in order to establish whether GLP-1 related agents may confer additional cardiovascular benefits to diabetic patients...
  70. ncbi Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
    ..Although this finding should be confirmed with more and larger studies, we suggest that any direct measure of vascular (endothelial) function may provide independent prognostic information in humans...
  71. ncbi Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension
    Eugenia Gkaliagkousi
    Department of Clinical Pharmacology, Cardiovascular Division, King s College London, London, UK
    J Hypertens 27:2310-20. 2009
    ..In this review, we examine the evidence that endothelial and/or platelet-derived nitric oxide are disturbed in essential hypertension, and whether such disturbances are cause or effect...
  72. ncbi Vascular effects of apelin in vivo in man
    Alan G Japp
    Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh, United Kingdom
    J Am Coll Cardiol 52:908-13. 2008
    ..This study was designed to establish the direct vascular effects of apelin in vivo in man...
  73. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  74. ncbi Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries
    Stefan Verlohren
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Charite University Hospitals, Humboldt University of Berlin, HELIOS Klinikum Berlin, Germany
    Hypertension 44:271-6. 2004
    ..We suggest that visceral periadventitial adipose tissue controls mesenteric arterial tone by inducing vasorelaxation via K(v) channel activation in vascular smooth muscle cells...
  75. pmc Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: an acarbose and nateglinide comparative study
    Toru Kato
    Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Cardiovasc Diabetol 9:12. 2010
    ..Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction...
  76. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...
  77. ncbi Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Hypertension 46:398-405. 2005
    ..These results suggest that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH...
  78. ncbi Heme oxygenase-1 induction restores high-blood-flow-dependent remodeling and endothelial function in mesenteric arteries of old rats
    Mohamed Lamine Freidja
    CNRS UMR 6214, Angers, France
    J Hypertens 29:102-12. 2011
    ..As heme oxygenase-1 (HO-1) is induced by hemodynamic forces in vascular smooth muscle and endothelial cells, we hypothesized that it might improve flow-dependent remodeling in aging...
  79. pmc Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome
    Abdelali Agouni
    INSERM U771, Centre National de la Recherche Scientifique Unite Mixte de Recherche, 6214, the Université d Angers, Angers, France
    Am J Pathol 173:1210-9. 2008
    ..These data provide evidence that circulating microparticles from MS patients influence endothelial dysfunction...
  80. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..b>Vasodilation to acetylcholine, but not to sodium nitroprusside, was lower (P<0...
  81. pmc Compensatory vasodilatation during hypoxic exercise: mechanisms responsible for matching oxygen supply to demand
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 590:6321-6. 2012
    ..Along these lines, this review will highlight the interactions between various local metabolic and endothelial derived substances that influence vascular tone during hypoxic exercise...
  82. ncbi Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool?
    An L Moens
    Department of Cardiology, University of Antwerp, University Hospital of Antwerp, Wilrijkstraat 10, 2650 Antwerp, Belgium
    Chest 127:2254-63. 2005
    ..In this review article, the pathophysiology of FMD, based on reactive hyperemia, is extensively discussed. Furthermore, an overview is given of the actual clinical indications of FMD measurement...
  83. ncbi Comparative profile of vasodilation by CVT-3146, a novel A2A receptor agonist, and adenosine in conscious dogs
    Gong Zhao
    CV Therapeutics, Inc, Palo Alto, CA 94304, USA
    J Pharmacol Exp Ther 307:182-9. 2003
    The purpose of this study was to determine the magnitude of vasodilation by CVT-3146 in different vascular beds and to compare it with that by adenosine in conscious dogs. Intravenous bolus injections of CVT-3146 (0.1-2...
  84. pmc Membrane raft-lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin
    Min Xia
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA
    Cardiovasc Res 89:401-9. 2011
    ..The present study was designed to test a hypothesis that visfatin causes coronary endothelial dysfunction through lysosome trafficking and fusion to cell membranes, membrane raft (MR) clustering, and formation of redox signalosomes...
  85. ncbi Endothelial-dependent vasodilation is reduced in mesenteric arteries from superoxide dismutase knockout mice
    Christy Lynn M Cooke
    Perinatal Research Centre, Department of Obstetrics Gynecology, 232 HMRC, University of Alberta, T6G 2S2 Edmonton, Alberta, Canada
    Cardiovasc Res 60:635-42. 2003
    ..To test this hypothesis in vivo, we utilized an animal model of endogenous oxidative stress, the CuZn superoxide dismutase (SOD) knockout mouse, to assess vascular function...
  86. ncbi Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    H A Golpon
    Department of Internal Medicine, Philipps University of Marburg, Baldinger Strasse, 35033, Marburg, Germany
    Regul Pept 102:81-6. 2001
    ..In conclusion, GLP-1 and amylin represent two additional peptides which may modulate pulmonary vascular tone...
  87. pmc C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway
    Qijun Zheng
    Department of Cardiovascular Surgery, Xijing Hospital, 4th Military Medical University, Xian, PR China
    Arterioscler Thromb Vasc Biol 31:2616-23. 2011
    ..The protein family CTRPs (C1q/TNF-related proteins) has recently been identified as APN paralogs and some CTRP members share APN's metabolic regulatory function. However, the vasoactive properties of CTRPs remain completely unknown...
  88. ncbi The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial
    A Rafnsson
    Karolinska Institutet, Department of Medicine, Cardiology Unit, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden
    Diabetologia 55:600-7. 2012
    ..We tested the hypothesis that oral administration of the dual endothelin receptor antagonist, bosentan, improves peripheral endothelial function in patients with type 2 diabetes and microalbuminuria...
  89. pmc Vascular nitric oxide: effects of exercise training in animals
    Richard M McAllister
    Department of Biomedical Sciences, University of Missouri, E102 Veterinary Medicine Building, Columbia, MO 65211, USA
    Appl Physiol Nutr Metab 33:173-8. 2008
    ..flow, in turn, could in part be accounted for by augmented endothelium-dependent, nitric oxide (NO)-mediated vasodilation. Studies have indeed demonstrated that endothelium-dependent, NO-mediated dilation of conductance-type vessels ..
  90. pmc A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation
    Scott Earley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1680, USA
    Mol Pharmacol 77:612-20. 2010
    ..Carvacrol also activates TRPV3-like cation currents in cerebral artery endothelial cells. Carvacrol elicits vasodilation of intact cerebral arteries (EC(50) = 4...
  91. ncbi The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes
    C G Schnackenberg
    Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA
    Kidney Int 59:1859-64. 2001
    Endothelium-dependent vasodilation is impaired in large conduit vessels in diabetes mellitus. Oxygen radicals contribute to the impaired endothelium-dependent vasodilation...
  92. ncbi Effect of spironolactone on endothelial dysfunction in rheumatoid arthritis
    A Syngle
    Healing Touch City Clinic, Fortis Heart Institute and Multispeciality Hospital, Chandigarh, India
    Scand J Rheumatol 38:15-22. 2009
    ..The aim of this study was to determine the effect of spironolactone on endothelial function in anti-tumour necrosis factor (TNF)-naive RA patients...
  93. ncbi Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo
    Stephanie E Wölfle
    Department of Physiology, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cardiovasc Res 82:476-83. 2009
    ..Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known...
  94. ncbi Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis
    Parisa Gazerani
    The Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Pain 151:606-16. 2010
    ..on the mechanical and chemical responsiveness of individual temporalis muscle nociceptors and muscle neurogenic vasodilation was investigated in female rats...
  95. ncbi Reduced endothelium-dependent and -independent dilation of conductance arteries in African Americans
    Umberto Campia
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Coll Cardiol 40:754-60. 2002
    ..The goal of this study was to determine whether racial differences exist in the functional behavior of conduit vessels...
  96. ncbi High-density lipoprotein restores endothelial function in hypercholesterolemic men
    Lukas E Spieker
    Cardiology, University Hospital, Zurich, Switzerland
    Circulation 105:1399-402. 2002
    ..Therefore, we investigated the effects of reconstituted HDL on endothelial function in hypercholesterolemic men...
  97. ncbi Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
    Le Ning Zhang
    Arete Therapeutics Inc, South San Francisco, CA 94080, USA
    Eur J Pharmacol 654:68-74. 2011
    ..Thus, preserving vasodilator EETs by inhibition of s-EH may be of therapeutic benefit by improving endothelial function in cardiometabolic diseases...
  98. pmc Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance
    Rong Li
    Department of Geriatrics, Xi Jing Hospital, Xian, PR China
    J Mol Cell Cardiol 49:508-15. 2010
    ..Reduced APN bioactivity allows unmitigated TNFalpha pro-apoptotic and pro-inflammatory actions, contributing to vascular injury in obesity/hyperlipidemia...
  99. ncbi Reproducibility of different methods to measure the endothelial function
    Steven Onkelinx
    Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Vasc Med 17:79-84. 2012
    ..001). The typical errors of measurements for FMD were lower than those for PAT. In conclusion, in this study, FMD demonstrated the best reliability for the within- and between-day and separate day measurements when compared to PAT...
  100. pmc The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function
    Kyra E Pyke
    Human Vascular Control Laboratory, School of Physical and Health Education, Queen s University, Kingston, ON, Canada
    J Physiol 568:357-69. 2005
  101. ncbi Relationships among hyperuricemia, metabolic syndrome, and endothelial function
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Am J Hypertens 24:770-4. 2011
    ..We evaluated the relationship of the severity of hyperuricemia and the flow-mediated vasodilatation of the brachial artery (FMD) in patients with and without the metabolic syndrome (MetS)...

Research Grants76

  1. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..of skeletal muscle arterioles using video microscopy to evaluate insulin induced nitric oxide dependent vasodilation. Co-investigators include an imaging physicist, a vascular biologist and an expert in mass spectroscopy to ..
    Girija G Konduri; Fiscal Year: 2013
    ..Persistent pulmonary hypertension of the newborn (PPHN) is a condition that results from failure of pulmonary vasodilation to occur at birth...
  3. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..Neural activity activates astrocytes, which, in turn, secrete substances that trigger local vasodilation of capillaries...
  4. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..At the same time, activation of RAS and XO in resistance arteries leads to impairment in endothelium- dependent vasodilation. We further hypothesize that both of these consequences of intermittent hypoxia worsen the severity of sleep ..
  5. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..the following three specific aims: 1) Contribution of BKCa channels to local metabolic and ischemic coronary vasodilation is diminished in Ossabaw swine with the metabolic syndrome...
  6. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..In sepsis, NOS also increases production of NO resulting in systemic vasodilation and worsening inflammation, which along with the increased oxidative stress contributes to the development of ..
  7. Antenatal Betamethasone in Late Preterm Gestation Lambs
    ..Respiratory morbidity from disorders of transition including pulmonary hypertension (impaired pulmonary vasodilation), transient tachypnea of newborn (inadequate lung liquid clearance) and respiratory distress syndrome (..
  8. Nitric Oxide Signaling with Heme Proteins
    William R Montfort; Fiscal Year: 2012
    ..produced in all mammalian tissues and is central to a wide-ranging array of physiological processes, including vasodilation, blood coagulation, memory formation, inflammation, angiogenesis, cell growth and cell death...
  9. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013 applicant): Nitric oxide plays a central role in respiratory physiology including regulation of airway tone, vasodilation, inflammation and lung morphogenesis...
  10. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ..of pharmacological inhibition and siRNA downregulation of TRPV4 on flow-induced Ca2+ entry, ROS/NO release, and vasodilation in HCA from CAD and non-CAD subjects...
  11. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012 applicant): Longitudinal transmission of vasodilatory signals along microvascular arterioles (conducted vasodilation;CVD) underlies the coordination of blood flow within microvascular networks and is an important mechanism for ..
  12. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Project Narrative Failure of pulmonary vasodilation to occur at birth results in persistent pulmonary hypertension of newborn...
  13. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    The purine nucleoside adenosine regulates such physiologic functions as heart rate, vasodilation and inflammation and receptors for adenosine have been targeted for such diverse conditions as Parkinson's Disease and, indirectly, ..
  14. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..The tPA treatment paradox could relate to vasodilation. Plasminogen activator vascular activity is mediated by the low density lipoprotein receptor (LRP)...
  15. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    ..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
  16. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    Abstract Stimulation of primary sensory neurons produces local vasodilation, plasma extravasation, and pain and is due largely to release of the neuropeptides substance P and calcitonin gene-related peptide (CGRP)...
  17. Vascular effects of dietary salt in humans with salt-resistant BP
    William B Farquhar; Fiscal Year: 2013
    ..e., brachial) and NO-mediated vasodilation of the cutaneous microvessels...
  18. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ..dysfunction and vasoconstriction in HTN-Preg;and consequently, increasing the activity of ETBR should promote vasodilation and decrease BP in HTN-Preg...
  19. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..While the common mechanism appears to be increased NO bioactivity and vasodilation, most such compounds are impractical as stroke therapeutics because of either delayed onset of action, or lack ..
  20. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  21. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..which SK3 channels regulate vascular tone, and how estrogen modulates SK3 channel activity and EDHF-induced vasodilation. Dr...
  22. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..These include vasodilation and the inhibition of oxidative stress, platelet aggregation, leukocyte chemotaxis and apoptosis...
  23. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..arteries in COPD respond to small increases in resistance at the level of the pulmonary capillaries by marked vasodilation, we recently developed a measure of the total pulmonary vascular volume (TPVV) on non-contrast, full-lung CT ..
  24. Neurovascular Dysfunction and Oxidative Stress in Renal Failure
    Jeanie Park; Fiscal Year: 2013
    ..In Aim 2, we will determine if CRF patients have impaired exercise-induced NO-mediated vasodilation, by measuring changes in brachial artery flow-mediated vasodilatation in response to whole-body exercise...
  25. Effects of Cocoa Flavonols on Myocardial Infarction Size and Post-Injury Injury
    Francisco Villarreal; Fiscal Year: 2009
    ..The consumption of flavanol rich cocoa leads to vasodilation which can be reversed by the use of an NO synthesis inhibitor...
  26. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    Shear stress acting on endothelial cells produces vasodilation. This is arguably the most important physiological endothelial mechanism of dilation and occurs in virtually every vascular bed...
    FRANCES ANN WALKER; Fiscal Year: 2012 able to release NO with nM Kds, while the FeII form has fM Kds and thus binds NO irreversibly, preventing vasodilation. We envision that the information obtained in this work will allow understanding the roles of the N-terminus, ..
  28. Regulation of Endothelial Nitric Oxide Synthase mRNA stability
    Jianxin Sun; Fiscal Year: 2013
    ..nitric oxide synthase (eNOS), is critical to the maintenance of vascular homeostasis through promoting vasodilation and inhibiting vascular smooth muscle cells proliferation, platelets aggregation, and leukocyte adhesion...
  29. Role of Oxidative Stress and Inflammation in HIV Cardiovascular Risk
    Cecilia M Shikuma; Fiscal Year: 2012
    ..dose atorvastatin on surrogate markers of CV risk over a 2 year period;specifically its effect on flow-mediated vasodilation of the brachial artery, on deposition of coronary artery calcium by electron beam tomography, and on changes in ..
  30. Sex-specific fetal programming of adult vascular dysfunction and hypertension
    ..We will examine the EDHF- and NO-mediated pathways and evaluate the mechanisms for impaired EDHF-mediated vasodilation by determining mRNA and protein levels of EDHF components SK3 and IK1 channels and connexins (CX37, CX40, and ..
  31. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..We hypothesize the greater cardiac output and systemic [unreadable]2-AR mediated vasodilation in haplotype 1 following normal dietary sodium intake will no longer be seen following dietary sodium ..
  32. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2013
    ..Aim 2 is to better understand the role of arginase activity in the progressive loss of vasodilation in the ischemic border region...
  33. Dietary control of angiogenesis in retinopathy models
    Lois Smith; Fiscal Year: 2013
    ..A third major PUFA metabolizing pathway, cytochrome P450s (Cyp450s) are implicated in vasodilation and inflammation...
  34. The Role of MKP-1 in innate immune responses to LPS
    Yusen Liu; Fiscal Year: 2010
    ..Severe sepsis is often associated with profound hypotension, massive vasodilation, shock, and multiple organ failure...
  35. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..patients;(2) we will determine whether local blockade of -adrenergic vasoconstriction and -adrenergic mediated vasodilation reduces the age- and disease-group differences in peripheral vascular responses to graded systemic hypoxia;(3) ..
  36. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..scavenger TEMPOL or endothelin-converting enzyme (ECE) inhibitor phosphoramidon before ischemia preserved vasodilation to bradykinin...
  37. Effects of Low Carbohydrate and Low Fat Diets on Endothelium Function in Obesity
    Shane A Phillips; Fiscal Year: 2013
    ..Endothelial- dependent vasodilation will be determined in isolated resistance arteries obtained from subcutaneous fat biopsies before and after 6 ..
  38. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    The ovarian hormone, relaxin, is an important signal causing profound renal and systemic vasodilation, as well as increased arterial compliance in the maternal circulation during normal pregnancy...
  39. Pro-inflammatory regulation of angiogenic gene expression in human trophoblast
    Donald S Torry; Fiscal Year: 2012
    ..receptor (Flt1) expressed on different cell types including endothelial cells and trophoblast where it promotes vasodilation, angiogenesis and cell survival...
  40. Calcium channels in arterial smooth muscle cells
    Jonathan H Jaggar; Fiscal Year: 2013
    ..hypertension and test the hypothesis that molecular targeting of a myocyte-specific N-terminal variant causes vasodilation. Aim 2 will investigate the hypothesis that 124 modulates myocyte CaV1...
  41. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..have opposing influences on blood pressure regulation, with estradiol tending to increase peripheral vasodilation, and with progesterone tending to increase vasoconstriction...
  42. PPARy and Uterine Vascular Dysfunction in Diabetic Pregnancy
    Natalia I Gokina; Fiscal Year: 2011
    ..causes endothelial dysfunction of uteroplacental arteries manifested by decreased NO- and EDHF-mediated vasodilation. Hyperglycemia-induced PKC activation results in impairment of Ca2+ signaling leading to decreased production ..
  43. Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury
    Kalev Freeman; Fiscal Year: 2013
    ..The application includes novel data indicating TBI causes impaired endothelium-dependent vasodilation, despite elevations in endothelial calcium signaling...
  44. Assembly and Trafficking of IK1 and SK3 in Endothelia
    Daniel C Devor; Fiscal Year: 2012
    ..Both IK and SK channels are activated during agonist-induced vasodilation, and knockout of these channels is associated with increased blood pressure...
  45. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..CNP causes vasodilation of epineurial arterioles and CNP activity/expression is decreased by diabetes...
  46. Targeting Inflammation to Treat Cardiovascular Aging in Humans
    Gary L Pierce; Fiscal Year: 2013
    ..of inflammation will improve vascular endothelial function (brachial artery flow-mediated endothelium-dependent vasodilation);and Aim 3 will test the hypothesis that chronic inhibition of inflammation will improve LV diastolic ..
  47. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ..We have recently shown that patients with pulmonary hypertension have a deficiency of RBC SNO that impairs RBC vasodilation, and that repletion of SNO is associated with improvements in both RBC bioactivity and pulmonary function...
  48. Developing fluorescent probes for the endogenous gaseous transmitters NO and H2S
    MICHAEL PLUTH; Fiscal Year: 2013
    ..Both NO and H2S are produced endogenously and are finely regulated by the body. Nitric oxide is beneficial for vasodilation and immune activity at low cellular concentrations but overproduction can lead to the proliferation of reactive ..
  49. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..The effects of CGRP release in the periphery are multifaceted, including induction of vasodilation and macrophage recruitment...
  50. Attenuated Functional Capacity in Combined Heart Failure &Type 2 Diabetes: ...
    CATHERINE RENEE MIKUS; Fiscal Year: 2013
    ..During exercise, shear stress stimulates production of nitric oxide (NO) from the endothelium, leading to vasodilation and redistribution of blood flow to working muscles...
  51. Ultrasound Assessment of Microvascular Function in Insulin Resistant Primates
    Jonathan R Lindner; Fiscal Year: 2011
    ..capillary responses to other physiologic responses such as exercise, reactive hyperemia, and NO-dependent vasodilation. ...
    Steven S Segal; Fiscal Year: 2013
    ..1) Hyperpolarization via activation of Ca2+-sensitive K+ channels (KCa), referred to as `rapid-conducted vasodilation'(RCVD;velocity >several mm/s) and mediated by electromechanical coupling, whereby intracellular Ca2+ ([..
  53. Fast calcium responses along arteriolar endothelium in vivo
    Pooneh Bagher; Fiscal Year: 2010
    ..signals that propagate from cell to cell along the endothelium to initiate SMC relaxation and thereby produce vasodilation. Our laboratory has shown that ACh initiates a bi-directional Ca2+ wave that propagates at -0...
  54. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2013
    ..Recent studies indicate that the AT2 receptor inhibits cell growth and induces vasodilation opposing the effects of Ang II at AT1 receptors...
  55. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
    ..ANP, BNP and CNP exert systemic actions that include vasodilation, natriuresis and reduced activation of the renin-angiotenin- aldosterone system...
  56. Lead and Vascular Reactivity to Acute Stress in Children
    Brooks Gump; Fiscal Year: 2009 not clear, however, it is presumed to involve a number of systems that regulate vasoconstriction and vasodilation, including the kallikrein-kinin system (KKS), oxidative stress, the renin-angiotensin system (RAS), the ..
  57. Role of BK subunits in ethanol-cholesterol synergistic inhibition of BK channel
    Anna Bukiya; Fiscal Year: 2011
    ..Cerebrovascular ischemia results from impaired vasodilation and/or enhanced constriction of cerebral arteries...
  58. Regulation of conducted hyperpolarization in microvascular endothelial cell tubes
    ERIK JOSEF BEHRINGER; Fiscal Year: 2012
    ..this hyperpolarization to consecutive smooth muscle cells (SMCs) along the vessel, resulting in conducted vasodilation (CVD) and increased tissue blood flow...
  59. Reversibility of Cardiovascular Injury with CPAP Use: Mechanisms Involved
    Claudia E Korcarz; Fiscal Year: 2013
    ..of CPAP therapy on two measures of arterial function, namely arterial stiffness and endothelium-dependent vasodilation. This study has four specific aims that address four inter- related hypotheses: To determine if (i) CPAP ..
    John M Canty; Fiscal Year: 2013
    ..Physiological end-points will include improvement in regional LV function and myocardial perfusion at rest and vasodilation. Aim 2 will evaluate the role of icMSCs and CDCs to amplify endogenous myocyte proliferation vs...
  61. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..associated with HTN-Preg, and consequently, increasing the activity of the AT2R system promotes vasodilation and decreases BP in HTN-Preg...
  62. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..COX)-prostanoid system, with the heme oxygenase (HO)-carbon monoxide (CO) system in the regulation of cerebral vasodilation. Previous studies from our laboratory and those from other investigators have shown that prostanoids generated ..
    Michael Heymann; Fiscal Year: 1999 affecting the perinatal changes in PBF and finally I will examine the mechanisms by which Et-1 might produce vasodilation, by examining the possible secondary role of NO production or of ATP-dependent K+ channel activation influence...
    Theoharis Theoharides; Fiscal Year: 2001
    ..test this premise by investigating: (a) the effect of CRH and urocortin on dura mast cell degranulation and vasodilation by measuring Evans blue of 125I-BSA extravasation in the dura of C57 BL/6J mice; vasodilation will also be ..
    Pin Lan Li; Fiscal Year: 2000
    Endothelium-dependent vasodilation plays an important role in the control of coronary vascular tone...
  66. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..A major limitation to the clinical use of nitroglycerin is nitrate tolerance, i.e. a rapid decline in vasodilation that occurs with continuous use...
  67. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular events...
  68. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..faculty mentor has recently documented that a single bout of exercise causes sustained peripheral vasodilation within the previously active skeletal muscle and is the result of histamine receptor activation...
    Kieren Mather; Fiscal Year: 2003
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
    William Pearce; Fiscal Year: 1992
    ..Second, experiments will be performed to test the hypothesis that hypoxic vasodilation is due to increased synthesis of cGMP by mechanisms which are more prominent in adult than in newborn cerebral ..
    Michael Joyner; Fiscal Year: 2004 ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  73. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
    ERIC FEIGL; Fiscal Year: 1999
    ..that simultaneously result in tachycardia, increases in myocardial contractility and beta-adrenergic vasodilation of the coronary circulation...
    Tony Lee; Fiscal Year: 2002
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
    Stuart Katz; Fiscal Year: 2004
    ..Adapted from the application): The applicant has previously demonstrated that impaired endothelium-dependent vasodilation in response to hormonal agonists and shear stress in patients with heart failure is attributable to reduced ..