vasodilation

Summary

Summary: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

Top Publications

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  2. ncbi Prognostic significance of endothelial dysfunction in hypertensive patients
    F Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Circulation 104:191-6. 2001
  3. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
  4. ncbi Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
  5. ncbi Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
  6. ncbi Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
  7. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  8. ncbi Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
  9. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  10. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001

Research Grants

  1. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2010
  2. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
  3. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1993
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
  5. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
  6. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
  7. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
  8. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
  9. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
  10. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010

Detail Information

Publications316 found, 100 shown here

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed...
  2. ncbi Prognostic significance of endothelial dysfunction in hypertensive patients
    F Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Circulation 104:191-6. 2001
    ..Methods and Results-- Endothelium-dependent and -independent vasodilation was investigated in 225 never-treated hypertensive patients (age, 35 to 54 years) by intra-arterial infusion of ..
  3. ncbi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
    ..We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events...
  4. ncbi Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
    ..We assessed the predictive value of FMD for incident CVD events in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  5. ncbi Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
    ..couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles...
  6. ncbi Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Endothelium-dependent vasodilation is only minimally altered in vessels of mice with DOCA-salt hypertension but seems to be mediated by hydrogen ..
  7. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  8. ncbi Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  9. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  10. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001
    ..We conclude that cannabinoids elicit profound coronary and cerebral vasodilation in vivo by direct activation of vascular cannabinoid CB(1) receptors, rather than via autoregulation, a ..
  11. ncbi Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  12. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...
  13. ncbi Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L'Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L'Aquila, Italy
    Hypertension 46:398-405. 2005
    ..These results suggest that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH...
  14. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..b>Vasodilation to acetylcholine, but not to sodium nitroprusside, was lower (P<0...
  15. ncbi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..Given the tonic interaction between the ET and NO systems, we conclude that diesel exhaust inhalation alters vascular reactivity to ET-1 probably through its effects on NO bioavailability...
  16. ncbi Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats
    Amanda J LeBlanc
    Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, West Virginia, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1713-23. 2009
    ..The purpose of this study was to determine how age and ovarian hormones affect flow-induced vasodilation in the coronary resistance vasculature...
  17. ncbi Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
    Thanh T Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Diabetes Care 32:2075-80. 2009
    Flicker light-induced retinal vasodilation may reflect endothelial function in the retinal circulation. We investigated flicker light-induced vasodilation in individuals with diabetes and diabetic retinopathy.
  18. ncbi Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women's Hospital, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 90:107-11. 2002
    ..Hyperglycemia, in particular, attenuates endothelium-dependent vasodilation in healthy subjects...
  19. ncbi Cellular signaling and potential new treatment targets in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Exp Diabetes Res 2007:31867. 2007
    ..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
  20. ncbi Reactive oxygen species and the control of vascular function
    Michael S Wolin
    Dept of Physiology, Basic Science Bldg, Rm 604, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 296:H539-49. 2009
    ....
  21. ncbi Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension
    Eugenia Gkaliagkousi
    Department of Clinical Pharmacology, Cardiovascular Division, King s College London, London, UK
    J Hypertens 27:2310-20. 2009
    ..In this review, we examine the evidence that endothelial and/or platelet-derived nitric oxide are disturbed in essential hypertension, and whether such disturbances are cause or effect...
  22. ncbi Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Cell Metab 11:379-89. 2010
    ..Endothelium-dependent vasodilation was impaired and endothelial cell VCAM-1 expression was increased in these animals...
  23. ncbi Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus
    Seon Mi Jin
    Department of Pediatrics, Eulji Medical Center, Seoul, Korea
    J Korean Med Sci 23:77-82. 2008
    ....
  24. ncbi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD)...
  25. ncbi gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension
    O Jung
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circulation 109:1795-801. 2004
    ..We hypothesized that the endothelial gp91phox-containing NADPH oxidase is predominant in generating the O2- to scavenge endothelial NO and thus is responsible for the development of endothelial dysfunction...
  26. ncbi Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
    ..Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra- and intracranial vessels in migraine without aura patients...
  27. ncbi Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  28. ncbi The effect of physical exercise on endothelial function
    Samanta Di Francescomarino
    Department of Clinical Science and Bioimaging, University of Chieti, Chieti, Italy
    Sports Med 39:797-812. 2009
    ..Thus, exercise may have a beneficial effect on the development of cardiovascular disease through preserving endothelial function...
  29. ncbi Relationship between brachial flow-mediated dilation and carotid intima-media thickness in an elderly cohort: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Atherosclerosis 197:840-5. 2008
    ..The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort...
  30. ncbi Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats
    Annemarieke E Loot
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Circulation 105:1548-50. 2002
    ..Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the effects of angiotensin-(1-7) on the progression of heart failure...
  31. ncbi Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability
    Malarvannan Pannirselvam
    Department of Pharmacology and Therapeutics and Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Br J Pharmacol 136:255-63. 2002
    ..8. These data suggest that increased production of superoxide anions and decreased availability of BH(4) result in an 'uncoupling' of nitric oxide synthase and endothelial dysfunction in SMA from db/db -/- mice...
  32. ncbi Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice
    L V d'Uscio
    Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 21:1017-22. 2001
    ..Thus, chemical inactivation of NO with O(2)(-) and reduced biosynthesis of NO are key mechanisms responsible for endothelial dysfunction in aortas of atherosclerotic apoE-deficient mice...
  33. ncbi Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation
    Ann E Donald
    Vascular Physiology Unit, UCL Institute of Child Health, London, United Kingdom
    J Am Coll Cardiol 51:1959-64. 2008
    ..Our aim was to determine reproducibility of the flow-mediated dilation (FMD) response profile, and discriminatory ability of the components...
  34. ncbi Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    Circulation 119:1284-92. 2009
    ..We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans...
  35. ncbi Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
    Ayano Yanaga
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:2415-8. 2006
    ..Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels...
  36. ncbi The influence of one-year treatment by angiotensin converting enzyme inhibitor on baroreflex sensitivity and flow-mediated vasodilation of the brachial artery in essential hypertension--comparison with calcium channel blockers
    Masanori Munakata
    Division of Hypertension and Cardiology, Tohoku Rosai Hospital, Sendai, Japan
    Clin Exp Hypertens 25:169-81. 2003
    ..Both baroreflex sensitivity and flow-mediated vasodilator function have been recognized to have prognostic significance in cardiovascular diseases. Long-term antihypertensive treatment effects on these parameters, however, remain unclear...
  37. ncbi Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  38. ncbi Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
    J R Hamilton
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    Circ Res 89:92-8. 2001
    ..The selective upregulation of PAR2 and PAR4 expression and the increased vascular response in HCAs after exposure to inflammatory stimuli suggest a role for these endothelial receptors during inflammation...
  39. ncbi Addition of milk prevents vascular protective effects of tea
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J 28:219-23. 2007
    ..We studied the vascular effects of tea, with or without milk, in humans and elucidated the impact of individual milk proteins in cell culture experiments, with isolated rat aortic rings and by HPLC analysis...
  40. ncbi Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus
    P J Chowienczyk
    Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King s College, London, United Kingdom
    J Am Coll Cardiol 34:2007-14. 1999
    We sought to determine whether a simple index of pressure wave reflection may be derived from the digital volume pulse (DVP) and used to examine endothelium-dependent vasodilation in patients with type II diabetes mellitus.
  41. ncbi Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction
    M Vona
    Cardiac Rehabilitation Center, Cardiology, Beauregard Hospital, Aosta, Italy
    Am Heart J 147:1039-46. 2004
    ..However, it is unknown whether this effect occurs in patients with recent myocardial infarction (AMI)...
  42. ncbi Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
    C de Wit
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Circ Res 86:649-55. 2000
    ..Our observations indicate that Cx40 is required for normal transmission of endothelium-dependent vasodilator responses and may underlie altered vasomotion patterns...
  43. ncbi Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity
    György Kerekes
    Cardiovascular Unit, Division of Rheumatology, and Laboratory of Immunology, Third Department of Medicine, Hungary
    J Rheumatol 35:398-406. 2008
    ..Endothelial dysfunction often precedes manifest atherosclerosis. We assessed endothelial dysfunction and atherosclerosis in RA in context with laboratory markers...
  44. ncbi Serum visfatin concentration and endothelial dysfunction in chronic kidney disease
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, 06018 Etlik Ankara, Turkey
    Nephrol Dial Transplant 23:959-65. 2008
    ..Recently, visfatin, a protein with insulin-mimetic properties, was shown to be associated with sVCAM-1. Thus, we hypothesised that visfatin may be a marker of ED in CKD...
  45. ncbi Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy
    Dong You
    Cardiovascular Research Center, INSERM U689, , 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Circulation 114:328-38. 2006
    ..BMC-induced NO production promoted a marked vasodilation and disrupted vascular endothelial-cadherin/beta-catenin complexes, leading to increased vascular permeability...
  46. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  47. ncbi Local potassium signaling couples neuronal activity to vasodilation in the brain
    Jessica A Filosa
    Department of Pharmacology, 89 Beaumont Avenue, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Nat Neurosci 9:1397-1403. 2006
    ..in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations...
  48. ncbi Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences
    Hua Cai
    Section of Cardiology, Department of Medicine, The Division of Biological Sciences and Pritzker School of Medicine, The University of Chicago, 5841 S Maryland Ave, MC6088, Chicago, IL 60637, USA
    Cardiovasc Res 68:26-36. 2005
    ..These modulations of endothelial cell function may at least partially underlie H2O2 contribution to the development of vascular disease...
  49. ncbi Leptin induces direct vasodilation through distinct endothelial mechanisms
    G Lembo
    Instituto di Ricovero e Cura a Carattere Scientifico, Neuromed, Pozzilli, Italy
    Diabetes 49:293-7. 2000
    ..Finally, the inhibition of nitric oxide synthase by NG-nitro-L-arginine-methyl ester does not modify blood pressure response to leptin, suggesting a predominant role of the EDHF mechanism in the hypotensive effect of leptin...
  50. ncbi Targeted disruption of the beta2 adrenergic receptor gene
    A J Chruscinski
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 274:16694-700. 1999
    ..Despite this defect in vasodilation, beta2-AR -/- mice can still exercise normally and actually have a greater total exercise capacity than wild ..
  51. ncbi Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    Jiu Chang Zhong
    Research Center of Medicine Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, and Department of Physiology, Chinese University of Hong Kong, Shatin, China
    Cardiovasc Res 74:388-95. 2007
    ..Our aim here was to explore the regulatory role of apelin in the aortic vascular tone in diabetic mice...
  52. ncbi Cerebral vascular dysfunction during hypercholesterolemia
    Jiro Kitayama
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
    Stroke 38:2136-41. 2007
    ..We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during hypercholesterolemia through a mechanism that involves oxidative stress...
  53. ncbi Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
    F J Miller
    Department of Internal Medicine, University of Iowa College of Medicine and Cardiovascular Center, and Veterans Administration Medical Center, Iowa City, USA
    Circ Res 82:1298-305. 1998
    ..Reduction in endothelial O2-. levels is not sufficient to improve endothelium-dependent relaxation. Generation of reactive oxygen species within the media may contribute to vasomotor dysfunction in atherosclerosis...
  54. ncbi Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus
    Tajinder P Singh
    Division of Cardiology, Department of Pediatrics, Wayne State University, Detroit, MI 48201, USA
    J Am Coll Cardiol 41:661-5. 2003
    The objective of this study was to evaluate endothelium-dependent vasodilation and carotid intimal-medial thickness (IMT) in children with insulin-dependent diabetes mellitus.
  55. ncbi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009
    ..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
  56. ncbi Normal flow-mediated vasodilatation of the brachial artery and carotid artery intima-media thickness in subclinical hypothyroidism
    M D Cabral
    Servico de Endocrinologia, Hospital Universitario Clementino Fraga Filho, Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
    Braz J Med Biol Res 42:426-32. 2009
    ..Further investigation is warranted to assess whether subclinical hypothyroidism, with and without TPO-Ab-positive serology, has any effect on endothelial function...
  57. ncbi Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
    Nicholas L Mills
    The BHF University Centre for Cardiovascular Science, Edinburgh University, The Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 32:2660-71. 2011
    ..We assess the role of combustion-derived-nanoparticles in mediating the adverse cardiovascular effects of air pollution...
  58. ncbi Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers
    M S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurology 75:1520-6. 2010
    ..However, it is unknown to what extent CGRP-induced vasodilation contributes to immediate head pain and whether the migraine-specific abortive drug sumatriptan, a 5-..
  59. ncbi 3',4'-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7days reperfusion in sheep
    Sheng Wang
    Howard Florey Institute, University of Melbourne, Victoria 3010, Australia
    Eur J Pharmacol 624:31-7. 2009
    ....
  60. ncbi Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    O Brouwers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 53:989-1000. 2010
    ..We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal...
  61. ncbi Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain
    Bea Zoer
    University Hospital Maastricht, P Debyelaan 25, AZ Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1026-34. 2010
    ..In conclusion, our experiments suggest that the mETC plays a critical role in O(2) sensing in fetal chicken femoral arteries. In contrast, hypoxia-induced relaxation appears not to be mediated by ROS or K(+) channels...
  62. ncbi The effect of tempol on endothelium-dependent vasodilatation and blood pressure
    Ulf Simonsen
    Department of Pharmacology, Faculty of Health Sciences, University Park 240, University of Aarhus, 8000 Aarhus C, Denmark
    Pharmacol Ther 122:109-24. 2009
    ..In summary, lowering of the oxidative stress by scavenging of free radicals may offer a new antihypertensive treatment strategy...
  63. ncbi Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 51:446-53. 2008
    ..Sodium nitroprusside-stimulated vasodilation was similar in the 2 groups...
  64. ncbi Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels
    Hideyuki Yamawaki
    Department of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada City, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 393:668-72. 2010
    ..Omentin (1-300 ng/ml) also relaxed NA pre-contracted mesenteric artery. Present study for the first time demonstrated that omentin has a vasodilating effect on isolated blood vessels, which is mediated through endothelium-derived NO...
  65. ncbi Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation
    Jian zhong Sheng
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    FASEB J 23:1138-45. 2009
    ..respectively) by the opener compounds NS309 and DCEBIO would augment stimulated nitric oxide (NO) synthesis and vasodilation in resistance arteries...
  66. ncbi Effects of vasodilation on cardiac output measured by PulseCO
    Koichi Yamashita
    Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko cho, Nankoku Shi, Kochi, 783 8505, Japan
    J Clin Monit Comput 21:335-9. 2007
    ..during cardiac surgery has been reported. In the present study, we investigated the effects of vasodilation by prostaglandin E1 (PGE1) on the relation between cardiac output measured by PulseCO and that by thermodilution...
  67. ncbi Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery
    C H Leo
    School of Medical Sciences, RMIT Univ, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 299:H502-11. 2010
    ..In early diabetes, nitrosothiol-mediated opening of K(+) channels may act in conjunction with NO stimulation of sGC to maintain endothelium-dependent relaxation despite the increase in vascular superoxide levels...
  68. ncbi Acute endotoxemia inhibits microvascular nitric oxide-dependent vasodilation in humans
    Rolf P Engelberger
    Division of Clinical Pathophysiology, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Switzerland
    Shock 35:28-34. 2011
    ..We investigated NO-dependent vasodilation in the skin microcirculation and plasma levels of asymmetric dimethylarginine (ADMA), a potent endogenous ..
  69. ncbi Cerebrovascular responses to altitude
    Julien V Brugniaux
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Respir Physiol Neurobiol 158:212-23. 2007
    ..A number of mediators contribute to the hypoxia-induced cerebral vasodilation, including adenosine, potassium channels, substance P, prostaglandins, and NO...
  70. ncbi Protease-activated receptor 2 and bradykinin-mediated vasodilation in the cerebral arteries of stroke-prone rats
    John S Smeda
    Division of Biomedical Sciences, Memorial University, St John s, Newfoundland, Canada
    Peptides 31:227-37. 2010
    ..by 2-furoyl-leucine-isoleucine-glycine-arginine-leucine-ornithine-amide (2Fly) produced endothelium-dependent vasodilation that was inhibited by K(+) depolarization, carbenoxolone, and the blockade of intermediate (IK(Ca)) plus small (..
  71. ncbi Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: an acarbose and nateglinide comparative study
    Toru Kato
    Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Cardiovasc Diabetol 9:12. 2010
    ..Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction...
  72. ncbi The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea
    Nicoline Jochmann
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, Campus Mitte, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Br J Nutr 99:863-8. 2008
    ..Similarly, both teas induced comparable endothelial-dependent vasodilation in rat aortic rings...
  73. ncbi Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: which method to choose?
    Marilia B Gomes
    Diabetes Unit, State University of Rio de Janeiro, Brazil
    Microvasc Res 76:132-3. 2008
    ..Diabetes Care 23, 215-220]. In this study, we assessed skin microvascular function of patients with type 1 diabetes using laser-Doppler perfusion monitoring (LDPM) coupled with physiological and pharmacological local vasodilator stimuli...
  74. ncbi Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure
    Stuart D Katz
    Department of Internal Medicine, Yale University School of Medicine, 135 College St, Ste 301, New Haven, CT 06510, USA
    Circulation 111:310-4. 2005
    ..Endothelial function is known to be impaired in subjects with chronic heart failure (CHF), but the association between endothelial function and subsequent mortality risk in CHF has not been previously reported...
  75. ncbi Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction
    Carmem Luíza Sartório
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Hypertension 50:919-25. 2007
    ..Underlying mechanisms involve inhibition of vascular angiotensin-converting enzyme upregulation and improvement of endothelial NO synthase-derived NO bioavailability...
  76. ncbi Are serum thyrotropin levels within the reference range associated with endothelial function?
    Henry Volzke
    Institut für Community Medicine, Ernst Moritz Arndt Universitat, Walther Rathenau Str 48, D 17487 Greifswald, Germany
    Eur Heart J 30:217-24. 2009
    ..In the present study, we investigated the association between serum TSH levels and flow-mediated dilation (FMD) as a measure of endothelial dysfunction...
  77. ncbi A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
    Pascal Bernatchez
    Providence Heart and Lung Institute, St Paul s Hospital, James Hogg Research Centre, 1081 Burrard St, Room 166, Vancouver BC Canada, V6Z 1Y6
    J Clin Invest 121:3747-55. 2011
    ..They also suggest a therapeutic application for regulating the eNOS/Cav-1 interaction in diseases characterized by decreased NO release...
  78. ncbi Prostaglandin E2(PGE2) induces headache in healthy subjects
    T Wienecke
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 29:509-19. 2009
    ..We hypothesized that infusion of PGE(2) might induce headache and vasodilation of cranial vessels. PGE(2) (0...
  79. ncbi Endothelial function in patients with migraine during the interictal period
    Federico A Silva
    Instituto de Investigaciones, Grupo de Ciencias Neurovasculares, Grupo de Investigación en Sistema Nervioso Autónomo, Fundacion Cardiovascular de Colombia, Floridablanca, Colombia
    Headache 47:45-51. 2007
    ..The aim of this study is to evaluate endothelial function in migraineurs subjects during the asymptomatic period...
  80. ncbi Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:545-62. 2009
    ..Conversely, blockers of IK(Ca) may prevent restenosis and that of BK(Ca) channels sepsis-dependent hypotension...
  81. ncbi Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide
    Brigitte Meyer
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    J Am Coll Cardiol 46:1011-8. 2005
    ..The aim of this study was to assess the predictive potency of impaired endothelium-dependent flow-mediated vasodilation (FMD) in patients with chronic heart failure (CHF)...
  82. ncbi The effects of periodontal therapy on vascular endothelial function: a pilot trial
    John R Elter
    SciMetrika, LLC, Research Triangle Park, NC, USA
    Am Heart J 151:47. 2006
    ....
  83. ncbi Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women
    Dilek Yavuz
    Department of Internal Medicine, Section of Endocrinology and Metabolism, Marmara University, Istanbul, Turkey
    Eur J Endocrinol 149:187-93. 2003
    ..The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women...
  84. ncbi Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes
    Fiorentina Roviezzo
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, Italy
    Arterioscler Thromb Vasc Biol 25:2349-54. 2005
    ..Here, using nonobese diabetic (NOD) mice at different disease stages, we have evaluated the role of PAR2 in the arterial vascular response during diabetes progression...
  85. ncbi Sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene-related peptide: effect of streptozotocin-induced diabetes
    M A Yorek
    Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Exp Diabesity Res 5:187-93. 2004
    ..the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation. Using immunohistochemistry, the authors determined that nerves innervating epineurial arterioles contain the ..
  86. ncbi Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease
    Stephan Fichtlscherer
    Departments of Internal Medicine IV, Division of Cardiology, Johann W. Goethe-University, Frankfurt am Main, Germany
    Circulation 109:178-83. 2004
    ..This effect seems to be related to an increase in the bioavailability of NO, probably as a consequence of an attenuated generation of reactive oxygen species by CYP 2C9 in endothelial cells...
  87. ncbi Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism
    Mari K Nishizaka
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, USA
    Circulation 109:2857-61. 2004
    ....
  88. ncbi Effects of GH replacement on endothelial function and large-artery stiffness in GH-deficient adults: a randomized, double-blind, placebo-controlled study
    Jamie C Smith
    Department of Medicine, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, Wales, UK
    Clin Endocrinol (Oxf) 56:493-501. 2002
    ..Endothelial dysfunction, characterized by reduced nitric oxide (NO) bioavailability, is a key early event in atherogenesis and is associated with increased vascular smooth muscle tone and arterial stiffening...
  89. ncbi The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization
    V Dishy
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA
    N Engl J Med 345:1030-5. 2001
    ..Therefore, polymorphisms of the beta2-adrenergic receptor are potentially important determinants of the vascular response to stress...
  90. ncbi Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
    T Lauer
    , Pneumologie, und Angiologie, , , Germany
    Proc Natl Acad Sci U S A 98:12814-9. 2001
    ..4-12 micromol/min) dose-dependently reduced basal NO(2)- and FBF and blunted acetylcholine-induced vasodilation and NO release by more than 80% and 90%, respectively...
  91. ncbi Novel approaches to improving endothelium-dependent nitric oxide-mediated vasodilatation
    Ulf Simonsen
    Department of Pharmacology, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark
    Pharmacol Rep 61:105-15. 2009
    ..converting enzyme inhibitors, and angiotensin receptor antagonists improve flow-evoked endothelium-dependent vasodilation in patients with hypertension and diabetes...
  92. ncbi Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channels
    Saula Vigili de Kreutzenberg
    Department of Clinical and Experimental Medicine, Cattedra di Malattie del Metabolismo, University of Padova, Via Giustiniani 2, 35128 Padua, Italy
    Atherosclerosis 169:147-53. 2003
    ..flow-mediated vasodilation (FMD) was assessed; (3) .bradykinin (BK) was infused during NO and prostaglandin inhibition (NO clamp); (4)...
  93. ncbi Detection of endothelial dysfunction with brachial artery ultrasound scanning
    Michael D Faulx
    Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-5038, USA
    Am Heart J 145:943-51. 2003
    ....
  94. ncbi Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Toxicol Sci 110:191-203. 2009
    ..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species...
  95. ncbi Increased dilator response to nitrate and decreased flow-mediated dilatation in migraineurs
    Ertan Yetkin
    Department of Cardiology, Inonu University School of Medicine, Malatya, Turkey
    Headache 47:104-10. 2007
    ..Accordingly we aimed to measure endothelium dependent and independent functions of brachial artery in migraineurs and healthy subjects...
  96. ncbi Augmentation index as a measure of peripheral vascular disease state
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, 32610, USA
    Curr Opin Cardiol 17:543-51. 2002
    ..This change in amplitude and timing of the reflected wave causes a generalized change in central arterial systolic and pulse pressure that is not detected by cuff pressure measurements in the brachial artery...
  97. ncbi Therapeutic potential of pharmacologically targeting arteriolar myogenic tone
    Michael A Hill
    Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Trends Pharmacol Sci 30:363-74. 2009
    ..The challenge, therefore, is to identify steps unique to the myogenic signaling pathway to enable specific pharmacological targeting...
  98. ncbi Black tea improves endothelial function in renal transplant recipients
    M R Ardalan
    Department of Nephrology, Tabriz Medical University, Tabriz, Iran
    Transplant Proc 39:1139-42. 2007
    ..Impaired endothelial function is an important contributor to cardiovascular diseases. We hypothesized that short-term black tea consumption may improve endothelium-dependent arterial dilation in kidney recipients...
  99. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..Here we show that cortical astrocytes in vivo possess a powerful mechanism for rapid vasodilation. We imaged the activity of astrocytes labeled with the calcium (Ca(2+))-sensitive indicator rhod-2 in ..
  100. ncbi Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, Chair of Internal Medicine, University of Udine, Udine, Italy
    Circulation 106:1211-8. 2002
    ..Evidence suggests that postprandial hypertriglyceridemia and hyperglycemia induce endothelial dysfunction through oxidative stress; however, the distinct role of these two factors is a matter of debate...
  101. ncbi In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes
    Amanda J Edgley
    Department of Physiology, Monash University, Clayton, Australia
    Am J Physiol Regul Integr Comp Physiol 295:R829-39. 2008
    We assessed the relative contributions of endothelium-derived relaxing factors to renal vasodilation in vivo and determined whether these are altered in established streptozotocin-induced diabetes...

Research Grants84

  1. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2010
    ..scavenger TEMPOL or endothelin-converting enzyme (ECE) inhibitor phosphoramidon before ischemia preserved vasodilation to bradykinin...
  2. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..test this premise by investigating: (a) the effect of CRH and urocortin on dura mast cell degranulation and vasodilation by measuring Evans blue of 125I-BSA extravasation in the dura of C57 BL/6J mice; vasodilation will also be ..
  3. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1993
    ..These peptides induce an endothelium-independent vasodilation which is associated with an enhanced vascular cAMP formation, and therefore have been suggested to be the ..
  4. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
    Persistent pulmonary hypertension of the newborn (PPHN) is a condition that results from failure of pulmonary vasodilation to occur at birth...
  5. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular events...
  6. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  7. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  8. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  9. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  10. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ..Aim 2 is to better understand the role of arginase activity in the progressive loss of vasodilation in the ischemic border region...
  11. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ..Aim 2 is to better understand the role of arginase activity in the progressive loss of vasodilation in the ischemic border region...
  12. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  13. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    STEVEN SEGAL; Fiscal Year: 1999
    ..Conduction appears integral to the local control of tissue blood flow; conducted (but not localized) vasodilation increases microvascular perfusion and attenuates sympathetic vasoconstriction...
  14. Aging, Obstructive Sleep Apnea, and Impaired Peripheral Vascular Control During S
    Frank A Dinenno; Fiscal Year: 2010
    ..patients;(2) we will determine whether local blockade of -adrenergic vasoconstriction and -adrenergic mediated vasodilation reduces the age- and disease-group differences in peripheral vascular responses to graded systemic hypoxia;(3) ..
  15. Vasodilation via selective pharmacological targeting of BK channel beta1 subunits
    Alex M Dopico; Fiscal Year: 2010
    In arterial myocytes, activation of Ca2+-gated K+ (BK) channels limits Ca2+ influx and, thus, leads to vasodilation. In most cells, BK channels consist of channel-forming (1) and accessory (2) subunits...
  16. Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human
    David D Gutterman; Fiscal Year: 2010
    Shear stress acting on endothelial cells produces vasodilation. This is arguably the most important physiological endothelial mechanism of dilation and occurs in virtually every vascular bed...
  17. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
  18. MICROCIRCULATORY DYNAMICS IN THE CORONARY CIRCULATION
    WILLIAM CHILIAN; Fiscal Year: 1999
    ..of shear stress through integrins to activate specific enzymes in endothelial cells; 2) shear stress-induced vasodilation occurs in the microcirculation of the beating heart; 3) shear stress-induced release of nitric oxide blunts the ..
  19. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2005
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  20. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2004
    ..and that NO decreases intracellular cADPR production and consequently lowers [Ca2+], thereby resulting in vasodilation. We will first examine the role of cADPR in the regulation of ryanodine receptor/Ca2+ release channel activity ..
  21. STUDIES ON ENDOTHELIAL DYSFUNCTION IN HEART FAILURE
    Stuart Katz; Fiscal Year: 2004
    ..Adapted from the application): The applicant has previously demonstrated that impaired endothelium-dependent vasodilation in response to hormonal agonists and shear stress in patients with heart failure is attributable to reduced ..