vasodilation

Summary

Summary: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

Top Publications

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  2. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
  3. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
  4. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  5. ncbi Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
  6. ncbi Prognostic significance of endothelial dysfunction in hypertensive patients
    F Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Circulation 104:191-6. 2001
  7. doi Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
  8. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
  9. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
  10. pmc Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008

Detail Information

Publications360 found, 100 shown here

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
    ..high-frequency ultrasonographic imaging of the brachial artery to assess endothelium-dependent flow-mediated vasodilation (FMD) was developed...
  2. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Endothelium-dependent vasodilation is only minimally altered in vessels of mice with DOCA-salt hypertension but seems to be mediated by hydrogen ..
  3. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  4. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  5. ncbi Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
    ....
  6. ncbi Prognostic significance of endothelial dysfunction in hypertensive patients
    F Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Circulation 104:191-6. 2001
    ..Methods and Results-- Endothelium-dependent and -independent vasodilation was investigated in 225 never-treated hypertensive patients (age, 35 to 54 years) by intra-arterial infusion of ..
  7. doi Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?
    Daniel J Green
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
    Hypertension 57:363-9. 2011
    ..Although this finding should be confirmed with more and larger studies, we suggest that any direct measure of vascular (endothelial) function may provide independent prognostic information in humans...
  8. pmc Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels
    Asif K Mustafa
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 109:1259-68. 2011
    ..Hydrogen sulfide (H(2)S) is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine γ-lyase (CSE), display pronounced hypertension with deficient vasorelaxant responses to acetylcholine...
  9. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
    ..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
  10. pmc Brain metabolism dictates the polarity of astrocyte control over arterioles
    Grant R J Gordon
    Brain Research Centre, Department of Psychiatry, University of British Columbia, British Columbia T2N 2B5, Canada
    Nature 456:745-9. 2008
    ..couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of arterioles...
  11. doi Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events
    Ronen Rubinshtein
    Division of Cardiovascular Diseases, Center of Coronary Physiology and Imaging, Mayo College of Medicine, MB4 523, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 31:1142-8. 2010
    ..We examined whether endothelial dysfunction, as detected by non-invasive peripheral arterial tonometry (EndoPAT), can predict late CV events...
  12. pmc Effect of exercise training on endothelium-derived nitric oxide function in humans
    Daniel J Green
    School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
    J Physiol 561:1-25. 2004
    ....
  13. ncbi Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
    Anthony R Smith
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Aging Cell 5:391-400. 2006
    ..Taken together, these results suggest a novel mechanism that at least partly explains the persistent loss of eNOS activity and endothelial-derived NO availability in aging conduit arteries...
  14. pmc Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis
    Joseph Yeboah
    Department of Internal Medicine Cardiology, University of Virginia Medical Center, Charlottesville, VA 22908, USA
    Circulation 120:502-9. 2009
    ..We assessed the predictive value of FMD for incident CVD events in the Multi-Ethnic Study of Atherosclerosis (MESA)...
  15. ncbi Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats
    Youqin Cheng
    Dept of Physiology, College of Medicine, Univ of Saskatchewan, 107 Wiggins Rd, Saskatoon, Saskatchewan, Canada S7N 5E5
    Am J Physiol Heart Circ Physiol 287:H2316-23. 2004
    ..Our study also demonstrated that endogenous CSE can generate sufficient H2S from exogenous L-cysteine to cause vasodilation. Future studies are merited to investigate direct contribution of endogenous H2S to regulation of vascular tone.
  16. pmc A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
    Pascal Bernatchez
    Providence Heart and Lung Institute, St Paul s Hospital, James Hogg Research Centre, 1081 Burrard St, Room 166, Vancouver BC Canada, V6Z 1Y6
    J Clin Invest 121:3747-55. 2011
    ..They also suggest a therapeutic application for regulating the eNOS/Cav-1 interaction in diseases characterized by decreased NO release...
  17. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  18. ncbi Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles
    Judy M Muller-Delp
    Department of Health and Kinesiology, Texas A and M University, College Station 77843, USA
    Am J Physiol Heart Circ Physiol 283:H1662-72. 2002
    ..Flow-induced vasodilation was also evaluated in the absence of pressure changes. Responses to ADO and SNP were not altered by age...
  19. pmc Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea
    Sanja Jelic
    Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy, and Critical Care Medicine, PH8 Center, Room 840, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:2270-8. 2008
    ..The effects of continuous positive airway pressure (CPAP) therapy on endothelial function and repair capacity were assessed...
  20. doi Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation
    Ann E Donald
    Vascular Physiology Unit, UCL Institute of Child Health, London, United Kingdom
    J Am Coll Cardiol 51:1959-64. 2008
    ..Our aim was to determine reproducibility of the flow-mediated dilation (FMD) response profile, and discriminatory ability of the components...
  21. ncbi Endothelial function in obstructive sleep apnea and response to treatment
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 169:348-53. 2004
    ..4% vs. -0.8%, difference of 5.2%, p < 0.001). Neither group showed significant change in NTG-induced vasodilation. Eight subjects who used nCPAP for over 3 months were reassessed on withdrawing treatment for 1 week...
  22. ncbi Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    Thomas Nystrom
    Dept of Internal Medicine, Stockholm South Hospital, Karolinska Institute, Stockholm SE 118 83, Sweden
    Am J Physiol Endocrinol Metab 287:E1209-15. 2004
    ..This beneficial vascular effect of GLP-1 adds yet another salutary property of the peptide useful in diabetes treatment...
  23. ncbi Endothelial dysfunction in pulmonary hypertension
    Rohit Budhiraja
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 109:159-65. 2004
  24. ncbi Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
    ..The aim of this research was to study whether the relation between endothelial function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular risk factors is affected by the baseline cardiovascular risk...
  25. ncbi gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension
    O Jung
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Circulation 109:1795-801. 2004
    ..We hypothesized that the endothelial gp91phox-containing NADPH oxidase is predominant in generating the O2- to scavenge endothelial NO and thus is responsible for the development of endothelial dysfunction...
  26. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
    ....
  27. ncbi Astrocyte-mediated control of cerebral blood flow
    Takahiro Takano
    Center for Aging and Developmental Biology, Department of Neurosurgery, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Neurosci 9:260-7. 2006
    ..Here we show that cortical astrocytes in vivo possess a powerful mechanism for rapid vasodilation. We imaged the activity of astrocytes labeled with the calcium (Ca(2+))-sensitive indicator rhod-2 in ..
  28. doi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009
    ..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
  29. doi Effects of gliclazide on endothelial function in patients with newly diagnosed type 2 diabetes
    Lu Lu Chen
    Department of Endocrinology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China
    Eur J Pharmacol 659:296-301. 2011
    ..Endothelial function was evaluated by flow-mediated vasodilation (FMD) before and after treatment...
  30. ncbi Insulin causes endothelial dysfunction in humans: sites and mechanisms
    Guido Arcaro
    Division of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona Medical School and Azienda Ospedaliera di Verona, Verona, Italy
    Circulation 105:576-82. 2002
    ..Endothelium plays a central role in atherogenesis. The in vivo effects of hyperinsulinemia on endothelial function of large conduit arteries are unknown...
  31. doi Assessment of atherosclerosis: the role of flow-mediated dilatation
    Marietta Charakida
    Vascular Physiology Unit, Great Ormond Street Hospital for Children, NHS Trust, University College London, 30 Guilford Street, London WC1N 3EH, UK
    Eur Heart J 31:2854-61. 2010
    ....
  32. doi Flow-mediated vasodilation is impaired in adult rat offspring exposed to prenatal hypoxia
    J S Morton
    Dept of Obstetrics Gynaecology and Physiology, Univ of Alberta, Edmonton, Alberta, Canada
    J Appl Physiol (1985) 110:1073-82. 2011
    ..that IUGR would cause changes in vascular function that would affect the mechanisms of flow-induced vasodilation later in life in an age- or sex-dependent manner...
  33. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  34. ncbi Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction
    Christopher Torrens
    Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, Southampton S016 5YA, United Kingdom
    Hypertension 47:982-7. 2006
    ..The concept of developmental origins of adult disease focuses predominately on fetal life but must also include a role for maternal cardiovascular function...
  35. ncbi Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation
    J J Zaritsky
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, CA, USA
    Circ Res 87:160-6. 2000
    ..1(-/-) animals did not dilate when the extracellular K(+) concentration was increased to 15 mmol/L. In summary, Kir2.1 gene expression in arterial smooth muscle is required for Kir currents and K(+)-induced dilations in cerebral arteries...
  36. ncbi Local potassium signaling couples neuronal activity to vasodilation in the brain
    Jessica A Filosa
    Department of Pharmacology, 89 Beaumont Avenue, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Nat Neurosci 9:1397-1403. 2006
    ..in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations...
  37. ncbi Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women
    Dogan Erdogan
    Baskent University, Faculty of Medicine, Cardiology Department, Konya, Turkey
    Atherosclerosis 184:431-7. 2006
    ..In the present study, FMD and IMT were studied in healthy subjects with lower and higher serum bilirubin concentrations in physiological ranges...
  38. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001
    ..We conclude that cannabinoids elicit profound coronary and cerebral vasodilation in vivo by direct activation of vascular cannabinoid CB(1) receptors, rather than via autoregulation, a ..
  39. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  40. doi Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension
    Eugenia Gkaliagkousi
    Department of Clinical Pharmacology, Cardiovascular Division, King s College London, London, UK
    J Hypertens 27:2310-20. 2009
    ..In this review, we examine the evidence that endothelial and/or platelet-derived nitric oxide are disturbed in essential hypertension, and whether such disturbances are cause or effect...
  41. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  42. pmc Postprandial endothelial dysfunction in subjects with new-onset type 2 diabetes: an acarbose and nateglinide comparative study
    Toru Kato
    Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
    Cardiovasc Diabetol 9:12. 2010
    ..Postprandial hyperglycemia is believed to affect vascular endothelial function. The aim of our study was to compare the effects of acarbose and nateglinide on postprandial endothelial dysfunction...
  43. ncbi Vascular effects of apelin in vivo in man
    Alan G Japp
    Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh, United Kingdom
    J Am Coll Cardiol 52:908-13. 2008
    ..This study was designed to establish the direct vascular effects of apelin in vivo in man...
  44. ncbi Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries
    Stefan Verlohren
    Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Charite University Hospitals, Humboldt University of Berlin, HELIOS Klinikum Berlin, Germany
    Hypertension 44:271-6. 2004
    ..We suggest that visceral periadventitial adipose tissue controls mesenteric arterial tone by inducing vasorelaxation via K(v) channel activation in vascular smooth muscle cells...
  45. ncbi Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men
    C A DeSouza
    Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, USA
    Circulation 102:1351-7. 2000
    In sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower age-related risk...
  46. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...
  47. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..b>Vasodilation to acetylcholine, but not to sodium nitroprusside, was lower (P<0...
  48. ncbi Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    Davide Grassi
    Dipartimento Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Hypertension 46:398-405. 2005
    ..These results suggest that, while balancing total calorie intake, flavanols from cocoa products may provide some cardiovascular benefit if included as part of a healthy diet for patients with EH...
  49. ncbi High-density lipoprotein restores endothelial function in hypercholesterolemic men
    Lukas E Spieker
    Cardiology, University Hospital, Zurich, Switzerland
    Circulation 105:1399-402. 2002
    ..Therefore, we investigated the effects of reconstituted HDL on endothelial function in hypercholesterolemic men...
  50. doi Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis
    Parisa Gazerani
    The Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Pain 151:606-16. 2010
    ..on the mechanical and chemical responsiveness of individual temporalis muscle nociceptors and muscle neurogenic vasodilation was investigated in female rats...
  51. ncbi The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes
    C G Schnackenberg
    Division of Nephrology and Hypertension, Georgetown University Medical Center, Washington, DC, USA
    Kidney Int 59:1859-64. 2001
    Endothelium-dependent vasodilation is impaired in large conduit vessels in diabetes mellitus. Oxygen radicals contribute to the impaired endothelium-dependent vasodilation...
  52. doi Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo
    Stephanie E Wölfle
    Department of Physiology, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cardiovasc Res 82:476-83. 2009
    ..Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known...
  53. ncbi Reduced endothelium-dependent and -independent dilation of conductance arteries in African Americans
    Umberto Campia
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Coll Cardiol 40:754-60. 2002
    ..The goal of this study was to determine whether racial differences exist in the functional behavior of conduit vessels...
  54. doi Effect of spironolactone on endothelial dysfunction in rheumatoid arthritis
    A Syngle
    Healing Touch City Clinic, Fortis Heart Institute and Multispeciality Hospital, Chandigarh, India
    Scand J Rheumatol 38:15-22. 2009
    ..The aim of this study was to determine the effect of spironolactone on endothelial function in anti-tumour necrosis factor (TNF)-naive RA patients...
  55. pmc A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation
    Scott Earley
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523 1680, USA
    Mol Pharmacol 77:612-20. 2010
    ..Carvacrol also activates TRPV3-like cation currents in cerebral artery endothelial cells. Carvacrol elicits vasodilation of intact cerebral arteries (EC(50) = 4...
  56. doi Uncoupling protein-2 protects endothelial function in diet-induced obese mice
    Xiao Yu Tian
    Institute of Vascular Medicine, Hong Kong SAR, China
    Circ Res 110:1211-6. 2012
    ..UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear...
  57. ncbi Reproducibility of different methods to measure the endothelial function
    Steven Onkelinx
    Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Vasc Med 17:79-84. 2012
    ..001). The typical errors of measurements for FMD were lower than those for PAT. In conclusion, in this study, FMD demonstrated the best reliability for the within- and between-day and separate day measurements when compared to PAT...
  58. doi Relationships among hyperuricemia, metabolic syndrome, and endothelial function
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Am J Hypertens 24:770-4. 2011
    ..We evaluated the relationship of the severity of hyperuricemia and the flow-mediated vasodilatation of the brachial artery (FMD) in patients with and without the metabolic syndrome (MetS)...
  59. pmc The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function
    Kyra E Pyke
    Human Vascular Control Laboratory, School of Physical and Health Education, Queen s University, Kingston, ON, Canada
    J Physiol 568:357-69. 2005
    ....
  60. doi Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
    Le Ning Zhang
    Arete Therapeutics Inc, South San Francisco, CA 94080, USA
    Eur J Pharmacol 654:68-74. 2011
    ..Thus, preserving vasodilator EETs by inhibition of s-EH may be of therapeutic benefit by improving endothelial function in cardiometabolic diseases...
  61. pmc Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance
    Rong Li
    Department of Geriatrics, Xi Jing Hospital, Xian, PR China
    J Mol Cell Cardiol 49:508-15. 2010
    ..Reduced APN bioactivity allows unmitigated TNFalpha pro-apoptotic and pro-inflammatory actions, contributing to vascular injury in obesity/hyperlipidemia...
  62. doi Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers
    M S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Neurology 75:1520-6. 2010
    ..However, it is unknown to what extent CGRP-induced vasodilation contributes to immediate head pain and whether the migraine-specific abortive drug sumatriptan, a 5-..
  63. ncbi A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study
    Lars Lind
    Department of Medicine, Uppsala University Hospital, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 25:2368-75. 2005
    Three different techniques to evaluate endothelium-dependent vasodilation in the peripheral circulation have been described but not simultaneously tested in a large-scale population-based setting...
  64. pmc Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    Matthias Totzeck
    Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
    Circulation 126:325-34. 2012
    Hypoxic vasodilation is a physiological response to low oxygen tension that increases blood supply to match metabolic demands...
  65. doi Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension
    Yuan Chieh Lee
    Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Circulation 124:1160-71. 2011
    ..Its chemical nature remains unknown. We determined whether palmitic acid methyl ester (PAME) was the PVATRF and whether its release and/or vasorelaxing activity decreased in hypertension...
  66. doi C-fiber function assessed by the laser doppler imager flare technique and acetylcholine iontophoresis
    Alistair Q Green
    The Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK
    Muscle Nerve 40:985-91. 2009
    b>Vasodilation induced by both acetylcholine iontophoresis (ACh Ionto) and the laser Doppler flare technique (LDIFT) can be used to measure small-fiber function. The aim of this study was to compare the neurogenic nature of these methods...
  67. doi Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men
    Andrew J Lucking
    University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, UK
    Circulation 123:1721-8. 2011
    ..The aim of the present study was to establish whether an exhaust particle trap could prevent these adverse cardiovascular effects in men...
  68. ncbi Flow-mediated dilation is associated with microalbuminuria independent of cardiovascular risk factors in type 2 diabetes - interrelations with arterial thickness and stiffness
    Hiroki Yokoyama
    Jiyugaoka Medical Clinic, Internal Medicine, Obihiro, Japan
    J Atheroscler Thromb 18:744-52. 2011
    ....
  69. pmc Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species
    Lorena B Furieri
    Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Madrid, Spain
    Br J Pharmacol 162:1819-31. 2011
    ..Exposure to mercury is known to increase cardiovascular risk but the underlying mechanisms are not well explored. We analysed whether chronic exposure to low mercury doses affects endothelial modulation of the coronary circulation...
  70. doi Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins
    Thomas D Giles
    Heart and Vascular Institute, Tulane University Medical Center, New Orleans, LA, USA
    J Clin Hypertens (Greenwich) 14:198-205. 2012
    ..Possible pharmacological interventions to restore normal function are suggested...
  71. pmc Reactive oxygen species and the control of vascular function
    Michael S Wolin
    Dept of Physiology, Basic Science Bldg, Rm 604, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 296:H539-49. 2009
    ....
  72. pmc Estrogen replacement restores flow-induced vasodilation in coronary arterioles of aged and ovariectomized rats
    Amanda J LeBlanc
    Center for Cardiovascular and Respiratory Sciences, West Virginia University, Morgantown, West Virginia, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1713-23. 2009
    ..The purpose of this study was to determine how age and ovarian hormones affect flow-induced vasodilation in the coronary resistance vasculature...
  73. ncbi Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 90:107-11. 2002
    ..Hyperglycemia, in particular, attenuates endothelium-dependent vasodilation in healthy subjects...
  74. doi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..Given the tonic interaction between the ET and NO systems, we conclude that diesel exhaust inhalation alters vascular reactivity to ET-1 probably through its effects on NO bioavailability...
  75. pmc Cellular signaling and potential new treatment targets in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Exp Diabetes Res 2007:31867. 2007
    ..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
  76. pmc Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice
    Christian Rask-Madsen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Cell Metab 11:379-89. 2010
    ..Endothelium-dependent vasodilation was impaired and endothelial cell VCAM-1 expression was increased in these animals...
  77. doi Evidence for a vascular factor in migraine
    Mohammad S Asghar
    Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Ann Neurol 69:635-45. 2011
    ..Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra- and intracranial vessels in migraine without aura patients...
  78. doi Noninvasive assessment of endothelial function in the skin microcirculation
    Haythem Debbabi
    Department of Non Invasive Investigations, Cardiovascular Research Centre, PARCC Inserm U970, Lariboisiere Hospital, Paris, France
    Am J Hypertens 23:541-6. 2010
    ..The aim of this study was to determine whether the laser Doppler response of skin microcirculation to acetylcholine, reflects that of conduit artery assessed by brachial artery flow-mediated dilation (FMD)...
  79. pmc Endothelial dysfunction and microvascular complications in type 1 diabetes mellitus
    Seon Mi Jin
    Department of Pediatrics, Eulji Medical Center, Seoul, Korea
    J Korean Med Sci 23:77-82. 2008
    ....
  80. pmc Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy
    Thanh T Nguyen
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
    Diabetes Care 32:2075-80. 2009
    Flicker light-induced retinal vasodilation may reflect endothelial function in the retinal circulation. We investigated flicker light-induced vasodilation in individuals with diabetes and diabetic retinopathy.
  81. pmc Relationship between brachial flow-mediated dilation and carotid intima-media thickness in an elderly cohort: the Cardiovascular Health Study
    Joseph Yeboah
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Atherosclerosis 197:840-5. 2008
    ..The aim of this study was to determine the relationship between brachial flow-mediated dilation (FMD) and carotid intima-media thickness (IMT) in a large multi-ethnic elderly cohort...
  82. doi The effect of physical exercise on endothelial function
    Samanta Di Francescomarino
    Department of Clinical Science and Bioimaging, University of Chieti, Chieti, Italy
    Sports Med 39:797-812. 2009
    ..Thus, exercise may have a beneficial effect on the development of cardiovascular disease through preserving endothelial function...
  83. ncbi Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats
    Annemarieke E Loot
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Circulation 105:1548-50. 2002
    ..Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the effects of angiotensin-(1-7) on the progression of heart failure...
  84. ncbi Increased expression of protease-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium-dependent relaxations to PAR2 and PAR4 agonists
    J R Hamilton
    Department of Pharmacology, University of Melbourne, Victoria, Australia
    Circ Res 89:92-8. 2001
    ..The selective upregulation of PAR2 and PAR4 expression and the increased vascular response in HCAs after exposure to inflammatory stimuli suggest a role for these endothelial receptors during inflammation...
  85. ncbi Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice
    L V d'Uscio
    Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 21:1017-22. 2001
    ..Thus, chemical inactivation of NO with O(2)(-) and reduced biosynthesis of NO are key mechanisms responsible for endothelial dysfunction in aortas of atherosclerotic apoE-deficient mice...
  86. ncbi Addition of milk prevents vascular protective effects of tea
    Mario Lorenz
    Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charite Universitatsmedizin Berlin, CCM, Chariteplatz 1, D 10117 Berlin, Germany
    Eur Heart J 28:219-23. 2007
    ..We studied the vascular effects of tea, with or without milk, in humans and elucidated the impact of individual milk proteins in cell culture experiments, with isolated rat aortic rings and by HPLC analysis...
  87. ncbi Impact of physical training and detraining on endothelium-dependent vasodilation in patients with recent acute myocardial infarction
    M Vona
    Cardiac Rehabilitation Center, Cardiology, Beauregard Hospital, Aosta, Italy
    Am Heart J 147:1039-46. 2004
    ..However, it is unknown whether this effect occurs in patients with recent myocardial infarction (AMI)...
  88. ncbi Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus
    P J Chowienczyk
    Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King s College, London, United Kingdom
    J Am Coll Cardiol 34:2007-14. 1999
    We sought to determine whether a simple index of pressure wave reflection may be derived from the digital volume pulse (DVP) and used to examine endothelium-dependent vasodilation in patients with type II diabetes mellitus.
  89. ncbi Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity
    György Kerekes
    Cardiovascular Unit, Division of Rheumatology, and Laboratory of Immunology, Third Department of Medicine, Hungary
    J Rheumatol 35:398-406. 2008
    ..Endothelial dysfunction often precedes manifest atherosclerosis. We assessed endothelial dysfunction and atherosclerosis in RA in context with laboratory markers...
  90. ncbi Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
    Ayano Yanaga
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 29:2415-8. 2006
    ..Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels...
  91. ncbi Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
    C de Wit
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Circ Res 86:649-55. 2000
    ..Our observations indicate that Cx40 is required for normal transmission of endothelium-dependent vasodilator responses and may underlie altered vasomotion patterns...
  92. pmc Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
    Gary L Pierce
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    Circulation 119:1284-92. 2009
    ..We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans...
  93. pmc Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability
    Malarvannan Pannirselvam
    Department of Pharmacology and Therapeutics and Smooth Muscle Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Br J Pharmacol 136:255-63. 2002
    ..8. These data suggest that increased production of superoxide anions and decreased availability of BH(4) result in an 'uncoupling' of nitric oxide synthase and endothelial dysfunction in SMA from db/db -/- mice...
  94. pmc Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  95. ncbi Serum visfatin concentration and endothelial dysfunction in chronic kidney disease
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, 06018 Etlik Ankara, Turkey
    Nephrol Dial Transplant 23:959-65. 2008
    ..Recently, visfatin, a protein with insulin-mimetic properties, was shown to be associated with sVCAM-1. Thus, we hypothesised that visfatin may be a marker of ED in CKD...
  96. ncbi The influence of one-year treatment by angiotensin converting enzyme inhibitor on baroreflex sensitivity and flow-mediated vasodilation of the brachial artery in essential hypertension--comparison with calcium channel blockers
    Masanori Munakata
    Division of Hypertension and Cardiology, Tohoku Rosai Hospital, Sendai, Japan
    Clin Exp Hypertens 25:169-81. 2003
    ..Both baroreflex sensitivity and flow-mediated vasodilator function have been recognized to have prognostic significance in cardiovascular diseases. Long-term antihypertensive treatment effects on these parameters, however, remain unclear...
  97. ncbi Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy
    Dong You
    Cardiovascular Research Center, INSERM U689, Hopital Lariboisiere, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Circulation 114:328-38. 2006
    ..However, mechanisms leading to the beneficial effects of BMCs and EPCs remain unclear...
  98. ncbi Targeted disruption of the beta2 adrenergic receptor gene
    A J Chruscinski
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305, USA
    J Biol Chem 274:16694-700. 1999
    ..Despite this defect in vasodilation, beta2-AR -/- mice can still exercise normally and actually have a greater total exercise capacity than wild ..
  99. ncbi Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    Jiu Chang Zhong
    Research Center of Medicine Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, and Department of Physiology, Chinese University of Hong Kong, Shatin, China
    Cardiovasc Res 74:388-95. 2007
    ..Our aim here was to explore the regulatory role of apelin in the aortic vascular tone in diabetic mice...
  100. ncbi Cerebral vascular dysfunction during hypercholesterolemia
    Jiro Kitayama
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
    Stroke 38:2136-41. 2007
    ..We tested the hypothesis that vasomotor function is impaired in cerebral arterioles during hypercholesterolemia through a mechanism that involves oxidative stress...
  101. ncbi Leptin induces direct vasodilation through distinct endothelial mechanisms
    G Lembo
    Instituto di Ricovero e Cura a Carattere Scientifico, Neuromed, Pozzilli, Italy
    Diabetes 49:293-7. 2000
    ..Finally, the inhibition of nitric oxide synthase by NG-nitro-L-arginine-methyl ester does not modify blood pressure response to leptin, suggesting a predominant role of the EDHF mechanism in the hypotensive effect of leptin...

Research Grants85

  1. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    TRAVIS HEIN; Fiscal Year: 2009
    ..scavenger TEMPOL or endothelin-converting enzyme (ECE) inhibitor phosphoramidon before ischemia preserved vasodilation to bradykinin...
  2. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2010
    ..scavenger TEMPOL or endothelin-converting enzyme (ECE) inhibitor phosphoramidon before ischemia preserved vasodilation to bradykinin...
  3. Low-dose Aspirin and Human Skin Blood Flow
    Lacy A Holowatz; Fiscal Year: 2010
    ..low-dose aspirin (81mg daily) or clopidogrel 1) consistently and significantly attenuates reflex cutaneous vasodilation (VD) in middle-aged (5813 years) human skin3;however the precise mechanisms underlying these responses are ..
  4. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ..in affecting the perinatal changes in PBF and finally I will examine the mechanisms by which Et-1 might produce vasodilation, by examining the possible secondary role of NO production or of ATP-dependent K+ channel activation influence...
  5. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..associated with HTN-Preg, and consequently, increasing the activity of the AT2R system promotes vasodilation and decreases BP in HTN-Preg...
  6. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    RAOUF KHALIL; Fiscal Year: 2009
    ..associated with HTN-Preg, and consequently, increasing the activity of the AT2R system promotes vasodilation and decreases BP in HTN-Preg...
  7. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..test this premise by investigating: (a) the effect of CRH and urocortin on dura mast cell degranulation and vasodilation by measuring Evans blue of 125I-BSA extravasation in the dura of C57 BL/6J mice; vasodilation will also be ..
  8. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2000
    ..test this premise by investigating: (a) the effect of CRH and urocortin on dura mast cell degranulation and vasodilation by measuring Evans blue of 125I-BSA extravasation in the dura of C57 BL/6J mice; vasodilation will also be ..
  9. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 1999
    ..test this premise by investigating: (a) the effect of CRH and urocortin on dura mast cell degranulation and vasodilation by measuring Evans blue of 125I-BSA extravasation in the dura of C57 BL/6J mice; vasodilation will also be ..
  10. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1991
    ..These peptides induce an endothelium-independent vasodilation which is associated with an enhanced vascular cAMP formation, and therefore have been suggested to be the ..
  11. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1992
    ..These peptides induce an endothelium-independent vasodilation which is associated with an enhanced vascular cAMP formation, and therefore have been suggested to be the ..
  12. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1993
    ..These peptides induce an endothelium-independent vasodilation which is associated with an enhanced vascular cAMP formation, and therefore have been suggested to be the ..
  13. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..While the common mechanism appears to be increased NO bioactivity and vasodilation, most such compounds are impractical as stroke therapeutics because of either delayed onset of action, or lack ..
  14. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2009
    ..While the common mechanism appears to be increased NO bioactivity and vasodilation, most such compounds are impractical as stroke therapeutics because of either delayed onset of action, or lack ..
  15. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 1993
    ..However, the mechanism by which oxygen causes pulmonary vasodilation is not known...
  16. EDRF IN NORMAL AND HYPERTENSIVE PULMONARY VASCULATURE
    Stephen Archer; Fiscal Year: 1991
    ..This "nitric oxide hypothesis" requires validation in the lung. Few investigators have correlated PA vasodilation with direct measurement of nitric oxide; most have relied on EDRF bioassays or the use of nonspecific EDRF-..
  17. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2009
    ..Respiratory morbidity from disorders of transition including pulmonary hypertension (impaired pulmonary vasodilation), transient tachypnea of newborn (inadequate lung liquid clearance) and respiratory distress syndrome (..
  18. Mechanisms of Renal Vasodilation by Relaxin
    Kirk Conrad; Fiscal Year: 2009
    The ovarian hormone, relaxin, is an important signal causing profound renal and systemic vasodilation, as well as increased arterial compliance in the maternal circulation during normal pregnancy...
  19. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..Respiratory morbidity from disorders of transition including pulmonary hypertension (impaired pulmonary vasodilation), transient tachypnea of newborn (inadequate lung liquid clearance) and respiratory distress syndrome (..
  20. Mechanisms of Renal Vasodilation by Relaxin
    Kirk P Conrad; Fiscal Year: 2010
    The ovarian hormone, relaxin, is an important signal causing profound renal and systemic vasodilation, as well as increased arterial compliance in the maternal circulation during normal pregnancy...
  21. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
    ..Persistent pulmonary hypertension of the newborn (PPHN) is a condition that results from failure of pulmonary vasodilation to occur at birth...
  22. Perinatal Origins of Chronic Mountain Sickness
    LORNA MOORE; Fiscal Year: 2009
    ..to UA blood flow and fetal growth variability and 3) HIF-regulated genes influencing UA vasoconstriction, vasodilation, or growth contribute to the variation in maternal physiologic responses to pregnancy in Andeans vs. Europeans...
  23. Perinatal Origins of Chronic Mountain Sickness
    Lorna G Moore; Fiscal Year: 2010
    ..to UA blood flow and fetal growth variability and 3) HIF-regulated genes influencing UA vasoconstriction, vasodilation, or growth contribute to the variation in maternal physiologic responses to pregnancy in Andeans vs. Europeans...
  24. MECHANISM OF CORONARY ENDOTHELIUM MEDIATED VASODILATION
    Pin Lan Li; Fiscal Year: 1999
    Endothelium-dependent vasodilation plays an important role in the control of coronary vascular tone...
  25. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..A major limitation to the clinical use of nitroglycerin is nitrate tolerance, i.e. a rapid decline in vasodilation that occurs with continuous use...
  26. MECHANISM OF CORONARY ENDOTHELIUM MEDIATED VASODILATION
    Pin Lan Li; Fiscal Year: 2000
    Endothelium-dependent vasodilation plays an important role in the control of coronary vascular tone...
  27. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark A Creager; Fiscal Year: 2010
    ..with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular events...
  28. Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A Subs
    Mark Creager; Fiscal Year: 2009
    ..with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular events...
  29. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..faculty mentor has recently documented that a single bout of exercise causes sustained peripheral vasodilation within the previously active skeletal muscle and is the result of histamine receptor activation...
  30. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Alain Baron; Fiscal Year: 1999
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  31. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Alain Baron; Fiscal Year: 2002
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  32. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  33. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Alain Baron; Fiscal Year: 2000
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  34. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Alain Baron; Fiscal Year: 2001
    ..OB/IR is also associated with impaired endothelial dependent vasodilation (EDV) characterized by reduced nitric oxide (NO) release...
  35. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  36. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 1999
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  37. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2001
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  38. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2000
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  39. MICROVASCULAR ABNORMALITIES IN SEPSIS
    Steven Hollenberg; Fiscal Year: 2002
    Septic shock, the leading cause of death in intensive care units, is characterized by vasodilation with decreased peripheral vascular resistance, which is often refractory to exogenously administered vasopressor agents...
  40. MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN
    William Pearce; Fiscal Year: 1990
    ..Second, experiments will be performed to test the hypothesis that hypoxic vasodilation is due to increased synthesis of cGMP by mechanisms which are more prominent in adult than in newborn cerebral ..
  41. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2000
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  42. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2001
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  43. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2003
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  44. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2004
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  45. NO AND EXERCISE VASODILATION IN HUMAN HYPERLIPIDEMIA
    Michael Joyner; Fiscal Year: 2002
    ..in ApoE knockout mice that display hypercholesterolemia, reduced endothelial function, limited exercise vasodilation, and blunted exercise tolerance. To study these issues in humans we will address the following specific aims...
  46. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2002
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  47. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2001
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  48. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2004
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  49. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2003
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  50. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ..Aim 2 is to better understand the role of arginase activity in the progressive loss of vasodilation in the ischemic border region...
  51. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ..Aim 2 is to better understand the role of arginase activity in the progressive loss of vasodilation in the ischemic border region...
  52. Nitric Oxide and Compensatory Coronary Vasodilation
    David Stepp; Fiscal Year: 2001
    ..when NO is inhibited, the contribution from adenosine may increase, serving as a mechanism of compensatory vasodilation. The mechanism by which this occurs, however, remains unclear...
  53. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  54. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2007
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  55. FEEDFORWARD CONTROL OF CORONARY BLOOD FLOW
    ERIC FEIGL; Fiscal Year: 1999
    ..that simultaneously result in tachycardia, increases in myocardial contractility and beta-adrenergic vasodilation of the coronary circulation...
  56. STUDIES ON ENDOTHELIAL DYSFUNCTION IN HEART FAILURE
    Stuart Katz; Fiscal Year: 2003
    ..Adapted from the application): The applicant has previously demonstrated that impaired endothelium-dependent vasodilation in response to hormonal agonists and shear stress in patients with heart failure is attributable to reduced ..
  57. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    STEVEN SEGAL; Fiscal Year: 1999
    ..Conduction appears integral to the local control of tissue blood flow; conducted (but not localized) vasodilation increases microvascular perfusion and attenuates sympathetic vasoconstriction...
  58. MECHANISMS OF ACTION OF VASODILATOR AGENTS
    ROBERT FURCHGOTT; Fiscal Year: 1992
    ..The long-term objectives of the proposed research are to increase our knowledge of the various mechanisms of vasodilation in general, and that of endothelium-dependent vasodilation in particular...
  59. SURGICAL CONTROL OF POST-TRAUMATIC LUNG INJURY
    David Fullerton; Fiscal Year: 1993
    ..12,14 On the other hand, the principle intracellular mechanisms of vasodilation are mediated through cAMP or cGMP. cGMP mechanisms may be endothelial-dependent or endothelial-independent...
  60. Aging, Obstructive Sleep Apnea, and Impaired Peripheral Vascular Control During S
    Frank A Dinenno; Fiscal Year: 2010
    ..patients;(2) we will determine whether local blockade of -adrenergic vasoconstriction and -adrenergic mediated vasodilation reduces the age- and disease-group differences in peripheral vascular responses to graded systemic hypoxia;(3) ..
  61. Vasodilation via selective pharmacological targeting of BK channel beta1 subunits
    Alex M Dopico; Fiscal Year: 2010
    ..In arterial myocytes, activation of Ca2+-gated K+ (BK) channels limits Ca2+ influx and, thus, leads to vasodilation. In most cells, BK channels consist of channel-forming (1) and accessory (2) subunits...
  62. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2009
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  63. Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human
    David Gutterman; Fiscal Year: 2009
    Shear stress acting on endothelial cells produces vasodilation. This is arguably the most important physiological endothelial mechanism of dilation and occurs in virtually every vascular bed...
  64. Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human
    David D Gutterman; Fiscal Year: 2010
    Shear stress acting on endothelial cells produces vasodilation. This is arguably the most important physiological endothelial mechanism of dilation and occurs in virtually every vascular bed...
  65. HDL Dysfunction and Vascular Inflammation
    Kirkwood Pritchard; Fiscal Year: 2006
    The overall goal of this application is to determine the mechanisms by which vascular inflammation impairs vasodilation. Recent reports from this laboratory demonstrate that an apoA-l mimetic, 4F, dramatically improves endothelium-and ..
  66. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2001
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
  67. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 1999
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
  68. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2000
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
  69. CEREBRAL VESSEL INNERVATION IN HYPERTENSION
    Tony Lee; Fiscal Year: 2002
    ..There is compelling evidence to indicate that nitric oxide (NO) plays a predominant role in cerebral neurogenic vasodilation. ChAT (Choline acetyltransferase) and NOS (nitric oxide synthase) are colocalized in the same cerebral ..
  70. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2002
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  71. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2004
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  72. MICROCIRCULATORY DYNAMICS IN THE CORONARY CIRCULATION
    WILLIAM CHILIAN; Fiscal Year: 1999
    ..of shear stress through integrins to activate specific enzymes in endothelial cells; 2) shear stress-induced vasodilation occurs in the microcirculation of the beating heart; 3) shear stress-induced release of nitric oxide blunts the ..
  73. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2003
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  74. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2001
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  75. REGULATION OF NITRIC OXIDE SYNTHASE IN DEVELOPING LUNG
    Philip Shaul; Fiscal Year: 2005
    ..description) Nitric oxide (NO), produced by endothelial NO synthase (eNOS), plays a key role in pulmonary vasodilation at birth and in the genesis of persistent pulmonary hypertension of the newborn (PPHN)...
  76. Role of circulating ATP and smooth muscle cell hyperpolarization in vascular cont
    Frank A Dinenno; Fiscal Year: 2010
    ..can act as a "sensor" and releases ATP during mismatches in oxygen demand and delivery, and this ATP can evoke vasodilation and improve local blood flow under such conditions via binding to purinergic (P2y) receptors on the endothelium...
  77. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2004
    ..and that NO decreases intracellular cADPR production and consequently lowers [Ca2+], thereby resulting in vasodilation. We will first examine the role of cADPR in the regulation of ryanodine receptor/Ca2+ release channel activity ..
  78. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2002
    ..and that NO decreases intracellular cADPR production and consequently lowers [Ca2+], thereby resulting in vasodilation. We will first examine the role of cADPR in the regulation of ryanodine receptor/Ca2+ release channel activity ..
  79. STUDIES ON ENDOTHELIAL DYSFUNCTION IN HEART FAILURE
    Stuart Katz; Fiscal Year: 2004
    ..Adapted from the application): The applicant has previously demonstrated that impaired endothelium-dependent vasodilation in response to hormonal agonists and shear stress in patients with heart failure is attributable to reduced ..
  80. Mechanism of Coronary Endothelium-mediated Vasodilation
    Pin Lan Li; Fiscal Year: 2001
    ..and that NO decreases intracellular cADPR production and consequently lowers [Ca2+], thereby resulting in vasodilation. We will first examine the role of cADPR in the regulation of ryanodine receptor/Ca2+ release channel activity ..
  81. STUDIES ON ENDOTHELIAL DYSFUNCTION IN HEART FAILURE
    Stuart Katz; Fiscal Year: 2002
    ..Adapted from the application): The applicant has previously demonstrated that impaired endothelium-dependent vasodilation in response to hormonal agonists and shear stress in patients with heart failure is attributable to reduced ..