Genomes and Genes
Summary: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Publications300 found, 100 shown here
- Narrative review: reversible cerebral vasoconstriction syndromesLeonard H Calabrese
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Ann Intern Med 146:34-44. 2007Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without ..
- Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteriesSalvatore Salomone
Stroke and Neurovascular Laboratory Regulation, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Pharmacol Res 62:465-74. 2010..Basilar arteries from SPK1(-/-) mice exhibited weaker vasoconstriction to both KCl and agonists (S1P and the prostanoid U46619) when compared to either wild type (WT) or SPK2(-/-)...
- Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertensionLisa A Lesniewski
Dept of Health and Kinesiology, Texas A and M University, College Station, Texas, USA
Am J Physiol Heart Circ Physiol 294:H1840-50. 2008..Collectively, these results indicate that increases in vasoconstrictor responsiveness resulting from diminished NO signaling in skeletal muscle arterioles precede the development of diabetes and hypertension in ZDF rats...
- Alpha1B-adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairmentMd Abdul Hye Khan
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
Acta Pharmacol Sin 29:193-203. 2008..This study examined whether alpha1B-adrenoceptors are involved in mediating adrenergically-induced renal vasoconstrictor responses in rats with pathophysiological and normal physiological states...
- Near-infrared spectroscopy provides an index of blood flow and vasoconstriction in calf skeletal muscle during lower body negative pressureT Hachiya
Aerospace Physiology Laboratory, School of Kinesiology, Simon Fraser University, Burnaby, BC, Canada
Acta Physiol (Oxf) 193:117-27. 2008..calf skeletal muscle oxygenated-Hb, after the removal of superficial tissue responses, were related to blood flow changes during orthostatic stress, and to determine the efficacy of using NIRS measurements as an index of vasoconstriction.
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsM Yanagisawa
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Nature 332:411-5. 1988..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
- Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholdsP Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesthesiology 87:835-41. 1997Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature...
- The importance of endothelin-1 for vascular dysfunction in cardiovascular diseaseFelix Bohm
Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden
Cardiovasc Res 76:8-18. 2007..Based on these observations and the biological effects induced by ET-1, including profound vasoconstriction, pro-inflammatory actions, mitogenic and proliferative effects, stimulation of free radical formation and ..
- Cellular signaling and potential new treatment targets in diabetic retinopathyZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Exp Diabetes Res 2007:31867. 2007..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
- Calcium transients in astrocyte endfeet cause cerebrovascular constrictionsSean J Mulligan
Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
Nature 431:195-9. 2004..b>Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF.
- Vascular plasticity in cerebrovascular disordersLars I H Edvinsson
Department of Clinical Experimental Research, Copenhagen University, Glostrup Hospital Research Park, Copenhagen, Denmark
J Cereb Blood Flow Metab 31:1554-71. 2011..Together, those findings provide new perspectives on the pathophysiology of ischemic stroke and point toward a novel way of reducing vasoconstriction, neuronal cell death, and thus neurologic deficits after stroke.
- Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclinPascale Gluais
Institut de Recherches Servier, 92150 Suresnes, France
Br J Pharmacol 146:834-45. 2005..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
- Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in miceMohd Shahid
Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Renal Physiol 295:F1836-44. 2008..1 microg.g(-1).min(-1); n = 6) resulted in further enhancement in vasoconstriction while natriuresis remained unaffected in response to TNF-alpha...
- Transcranial color doppler study for reversible cerebral vasoconstriction syndromesShih Pin Chen
Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
Ann Neurol 63:751-7. 2008Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published.
- SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstrictionSung Sen Yang
Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
J Am Soc Nephrol 21:1868-77. 2010..In summary, SPAK-null mice have defects of NCC in the kidneys and NKCC1 in the blood vessels, leading to hypotension through renal salt wasting and vasodilation. SPAK may be a promising target for antihypertensive therapy...
- Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty ratsXiao Lu
Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
Cardiovasc Diabetol 9:19. 2010..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
- ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in ratSaema A S Beg
Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
J Cereb Blood Flow Metab 26:846-56. 2006..Cerebral ischemia after SAH involves vasoconstriction and subsequent reduction in the CBF...
- Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) geneW Steudel
Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Circ Res 81:34-41. 1997..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
- Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstrictionS S McDaniel
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001..These results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction...
- Glial cells dilate and constrict blood vessels: a mechanism of neurovascular couplingMonica R Metea
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 26:2862-70. 2006..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
- Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal dietChristopher Torrens
Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
Br J Nutr 101:27-33. 2009..b>Vasoconstriction to endothelin was significantly enhanced in all groups compared with controls (-log effective concentration ..
- Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensorHeather A Drummond
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA
Hypertension 44:643-8. 2004..These data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins...
- Air pollution and cardiac remodeling: a role for RhoA/Rho-kinaseZhekang Ying
Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
Am J Physiol Heart Circ Physiol 296:H1540-50. 2009..In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution...
- Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flowJoseph E Brayden
Department of Pharmacology, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Clin Exp Pharmacol Physiol 35:1116-20. 2008..to myocyte depolarization, which stimulates Ca2+ entry via voltage-dependent Ca2+ channels (VDCC), leading to vasoconstriction. The TRPV4 channels in arterial myocytes are activated by epoxyeicosatrienoic acids, and activation of the ..
- Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunctionC A Gunnett
Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA, USA
Arterioscler Thromb Vasc Biol 25:1617-22. 2005....
- Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndromeU Deniz Dincer
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, USA
Microcirculation 13:587-95. 2006OBJECTIVE: This study tested whether alpha -adrenoceptor-mediated coronary vasoconstriction is augmented in the metabolic syndrome and is accompanied by the alteration of specific alpha(1)- and alpha(2)-coronary adrenoceptors...
- Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slicesRenate Paddenberg
University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
Respir Res 7:93. 2006Acute alveolar hypoxia causes pulmonary vasoconstriction (HPV) which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet...
- Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing menFrank A Dinenno
Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523 1582, USA
J Physiol 567:311-21. 2005..we tested the hypothesis that the normal ability of muscle contractions to blunt sympathetic alpha-adrenergic vasoconstriction (functional sympatholysis) is impaired with age in healthy humans...
- Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscleBrett S Kirby
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523 1582, USA
J Physiol 586:4305-16. 2008..in Protocol 1, we tested the hypothesis that exogenous ATP can blunt direct postjunctional alpha-adrenergic vasoconstriction in humans...
- Mechanisms of hydrogen peroxide-induced vasoconstriction in the isolated perfused rat kidneyJ M Moreno
Departamento de Fisiologia, Facultad de Medicina, Granada, Spain
J Physiol Pharmacol 61:325-32. 2010..H(2)O(2) induced vasoconstriction in the isolated rat kidney in a concentration-dependent manner...
- Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPKHardip Sandhu
Department of Clinical Experimental Research, Glostrup Research Institute, Ndr Ringvej 69, 2600 Glostrup, Denmark
Toxicol Appl Pharmacol 249:25-32. 2010..Thus, the MAPK-mediated upregulation of contractile ET(B) receptors in cerebral arteries might be a pharmacological target for the treatment of smoke-associated cerebral vascular disease like stroke...
- Prostaglandins and radical oxygen species are involved in microvascular effects of hyperoxiaA Rousseau
Departments of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden
J Vasc Res 47:441-50. 2010Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood...
- Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteriesOlga N Lekontseva
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Menopause 17:516-23. 2010..However, the specific impact of aging and/or Ovx on this pathway remains unknown. We hypothesized that aging exacerbates MMP-mediated vasoconstriction in an ovary-deficient state.
- Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstrictionFarzaneh Ketabchi
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Am J Physiol Lung Cell Mol Physiol 297:L977-83. 2009..However, the effects of hypercapnia with or without acidosis on hypoxic pulmonary vasoconstriction (HPV) and oxygen diffusion capacity of the lung are controversial...
- Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degenerationDomniki N Papadopoulou
Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
Ophthalmology 116:1755-61. 2009..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
- Endothelial dysfunction and vascular diseaseP M Vanhoutte
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Acta Physiol (Oxf) 196:193-222. 2009..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
- Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptorsMichel Feletou
Department of Angiology, Institut de Recherches Servier, Suresnes, France
Br J Pharmacol 156:563-74. 2009..Nevertheless, because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium-dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes...
- Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass graftingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Am J Cardiol 103:216-20. 2009..These differences are present and can be identified preoperatively by FMD...
- Endothelium-dependent contractions: when a good guy turns bad!Paul M Vanhoutte
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
J Physiol 586:5295-304. 2008..Endothelium-dependent contractions are exacerbated by ageing, obesity, hypertension and diabetes, and thus are likely to contribute to the endothelial dysfunction observed in older people and in essential hypertensive patients...
- Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activationMichael W Brands
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
Hypertension 56:879-84. 2010..These data suggest that IL-6-dependent activation of the renal janus kinase 2/signal transducer and activator of transcription 3 pathway plays a role in Ang II hypertension but not by mediating the effect of Ang II to decrease total RBF...
- Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vesselsLuis Michea
Laboratory of Cellular and Molecular Physiology, Faculty of Medicine, University Los Andes, S Carlos Apoquindo 2200, Las Condes, 6782468 Santiago, Chile
Endocrinology 146:973-80. 2005..Inhibitors of ERK 1/2 phosphorylation (15 microm PD98059) had no effect on aldosterone-mediated vasoconstriction. Inhibition of protein kinase C with 1 microm bi-sindolylmaleimide I and/or inhibition of NHE1 with 100 ..
- Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstrictionBeate Fuchs
Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Aulweg 130, 35392 Giessen, Germany
Respir Physiol Neurobiol 174:282-91. 2010Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism of the lung that matches blood perfusion with alveolar ventilation to optimize gas exchange...
- The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstrictionP Wangemann
Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
Hear Res 115:113-8. 1998..Elevation of the K+ concentration from 3.6 to 150 mM in the superfusate caused a transient vasoconstriction. The amplitude of the K+-induced vasoconstriction depended strongly on the applied intravascular pressure...
- Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstrictionCatherine Vial
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN United Kingdom
J Biol Chem 280:30705-11. 2005....
- Sirolimus-eluting stents associated with paradoxic coronary vasoconstrictionMario Togni
Swiss Cardiovascular Center Bern, Bern, Switzerland
J Am Coll Cardiol 46:231-6. 2005..In contrast, there was exercise-induced vasoconstriction of the proximal and distal vessel segments adjacent to SESs (-12 +/- 4% and -15 +/- 6%, respectively; p < ..
- S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphateWilliam S Szczepaniak
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Physiol Lung Cell Mol Physiol 299:L137-45. 2010..S1P-induced vasoconstriction was reduced by 64% by concomitant administration of the Rho-kinase inhibitor Y27632 (10 microM)...
- Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependentE A Silveira
Departamento de Ciencias Fisiologicas, Universidade Federal do Espirito Santo, Vitoria, ES, Brasil
Braz J Med Biol Res 43:492-9. 2010..Results suggest that acute lead administration affects the endothelium, releasing cyclooxygenase-derived vasoconstrictors and involving reactive oxygen species...
- Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cellsXiao ru Yang
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA
Adv Exp Med Biol 661:109-22. 2010..Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary ..
- Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxideY J Gao
Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
Br J Pharmacol 151:323-31. 2007..Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated...
- Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertensionA Armenia
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Acta Pharmacol Sin 29:564-72. 2008..This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats...
- Alterations in phenylephrine-induced contractions and the vascular expression of Na+,K+-ATPase in ouabain-induced hypertensionLuciana V Rossoni
Department of Pharmacology and Therapeutics, Facultad de Medicina, , Spain
Br J Pharmacol 135:771-81. 2002..These results suggest that chronic administration of ouabain induces hypertension and regional vascular alterations, the latter possibly as a consequence of the hypertension...
- Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscleToshio Kitazawa
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
J Physiol 546:879-89. 2003....
- Hindquarters vasoconstriction through central GABA(B) receptors in conscious ratsYumi Takemoto
Neurophysiology, Hiroshima University Graduate School of Medical Sciences, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
Exp Physiol 88:491-6. 2003..The results suggest that GABA(B) receptor stimulation via the cisterna magna induced hindquarters vasoconstriction, probably due to central disinhibition of sympathetic activity.
- Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATAThomas F Floyd
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Appl Physiol 95:2453-61. 2003..It is also accompanied by a fall in arterial Pco2 leading to uncertainty as to whether the cerebral vasoconstriction is totally or only in part caused by arterial hypocapnia...
- Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosteroneT R Uhrenholt
Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
Circ Res 93:1258-66. 2003..We conclude that aldosterone inhibits depolarization-induced vasoconstriction in renal afferent arterioles by a rapid nongenomic mechanism that is initiated by mineralocorticoid receptor ..
- Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodelingErik N T P Bakker
Department of Pharmacology, University of Aarhus, Aarhus, Denmark
J Vasc Res 41:174-82. 2004Remodeling of resistance arteries is a key feature in hypertension. We studied the transition of vasoconstriction to remodeling in isolated rat skeletal muscle arterioles...
- Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhageSaema Ansar
Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
Am J Physiol Heart Circ Physiol 293:H3750-8. 2007..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
- Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasmM Tosaka
Department of Neurosurgery, Gunma University School of Medicine, The Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
Stroke 32:2913-9. 2001..To understand the involvement of S1P in cerebral vasospasm, we investigated the effect of S1P on vasocontraction of the canine basilar artery in vitro and in vivo...
- Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstrictionY M Smulders
Department of Internal Medicine, Academic Medical Center, Suite F4 222, 9, 1105 AZ, Meibergdreef, The Netherlands
Cardiovasc Res 48:23-33. 2000..Historic studies indicate that this discrepancy is largely explained by pulmonary vasoconstriction caused by vasoactive mediators, released mainly by activated platelets...
- Increased vasoconstrictor sensitivity to glucocorticoids in essential hypertensionB R Walker
Department of Medicine, Western General Hospital, University of Edinburgh, Scotland, UK
Hypertension 27:190-6. 1996..We studied 11 patients with essential hypertension and 11 matched normotensive control subjects. Dermal vasoconstriction after topical application of both cortisol (16 +/- 4 versus 32 +/- 5 U, control subjects versus hypertensive ..
- Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteriesN L Hoel
Department of Clinical Experimental Research, Glostrup University Hospital, Denmark
Neuroreport 12:1605-8. 2001..8+/-0.4). The response was inhibited by the 5-HT(1B/1D) selective antagonist GR55562 (pEC50(fresh) 5.1+/-0.2 and pEC50(cultured) 6.0+/-0.3). The organ model might mimic the phenotypic changes during cerebrovascular diseases...
- Inward remodeling follows chronic vasoconstriction in isolated resistance arteriesErik N T P Bakker
Academic Medical Center, University of Amsterdam, Department of Medical Physics and Cardiovascular Research, Institute Amsterdam (CRIA, The Netherlands
J Vasc Res 39:12-20. 2002The hypothesis was tested that chronic vasoconstriction is followed by a structural reduction in lumen diameter, measured at full dilation. An in vitro model of pressurized rat skeletal muscle arterioles was used...
- Contribution of pulmonary vasoconstriction to haemodynamic instability after acute pulmonary embolism. Implications for treatment?Y M Smulders
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
Neth J Med 58:241-7. 2001..However, there is evidence to indicate that vasoconstriction is a very important contributor to the initial increase in pulmonary vascular resistance after pulmonary ..
- TNF-alpha induced bronchial vasoconstrictionE M Wagner
Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA
Am J Physiol Heart Circ Physiol 279:H946-51. 2000..05). Since others have shown TNF-alpha caused coronary vasoconstriction through endothelial release of endothelin-1 (ET-1), an ET-1 antagonist was used to block bronchial ..
- Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in ratsMasahiko Oka
Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Circ Res 100:923-9. 2007Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH)...
- Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697David P Wilson
Smooth Muscle Research Group and Department of Biochemistry and Molecular Biology, University of Calgary Faculty of Medicine, 3330 Hospital Drive N.W, Calgary, Alberta, Canada T2N 4N1
Biochem J 389:763-74. 2005....
- Effect of chronic hypoxia on voltage-independent calcium influx activated by 5-HT in rat intrapulmonary arteriesLise Rodat
Universite Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, 146 rue Leo Saignat, F33076 Bordeaux, France
Pflugers Arch 454:41-51. 2007....
- Therapeutic potential of pharmacologically targeting arteriolar myogenic toneMichael A Hill
Dalton Cardiovascular Research Center and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
Trends Pharmacol Sci 30:363-74. 2009The arteriolar myogenic response, which is defined as vasoconstriction to increases in intraluminal pressure and, conversely, dilation to a reduction in pressure, is key in the setting of vascular resistance, local control of ..
- Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin IIArthur C M Mulders
Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 26:2043-8. 2006..This pathway may be of importance under pathological circumstances with reduced NO bioavailability. Moreover, a disturbed sphingolipid metabolism in the vascular wall may lead to reduced NO bioavailability and endothelial dysfunction...
- Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertensionJ M Launay
CR C Bernard Pathologie expérimentale et communications cellulaires, IFR6, Services de Biochimie et d Angio Hématologie, Hôpital Lariboisière AP HP, Paris, France
Nat Med 8:1129-35. 2002..These data show that activation of 5-HT(2B) receptors is a limiting step in the development of pulmonary hypertension...
- Constrictor and dilator effects of angiotensin II on cerebral arteriolesJean-Martin Vincent
Laboratoire de Pharmacologie, , , 5 rue Albert Lebrun, 54000 Nancy, France
Stroke 36:2691-5. 2005..1+/-1.0% at 10(-6) mol/L. Captopril significantly decreased Ang I-induced vasoconstriction (-4.0+/-0.9 versus -21.3+/-2.5%; n=4). Telmisartan reversed Ang II-induced vasoconstriction (9.5+/-2...
- Rhythmicity in arterial smooth muscleRebecca E Haddock
Division of Neuroscience, John Curtin School of Medical Research, GPO Box 334, Canberra, ACT, 2601, Australia
J Physiol 566:645-56. 2005....
- The effects of autoantibodies against the second extracellular loop of alpha(1)-adrenoceptor on vasoconstrictionLi Yan
Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi, PR China
Basic Res Cardiol 104:581-9. 2009..aortic rings, renal artery, middle cerebral artery, and coronary artery segments, alpha(1)-AAB induced vasoconstriction in a concentration-dependent fashion, which can be completely blocked by prazosin, a selective alpha(1)-..
- Assessment of endothelial function of large, medium, and small vessels: a unified myographXiao Lu
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
Am J Physiol Heart Circ Physiol 300:H94-H100. 2011..In conclusion, an isovolumic myograph was used to unify arterial vasoreactivity from large to small arteries and shows the uniformity of wall stress and %tension throughout the range of vessel sizes...
- Postpartum angiopathy and other cerebral vasoconstriction syndromesAneesh B Singhal
Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neurocrit Care 3:91-7. 2005The phenomenon of reversible cerebral arterial segmental vasoconstriction has been associated with several conditions including pregnancy and puerperium ("postpartum angiopathy"), thunderclap headache, and use of ..
- Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase CScott A Barman
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
Am J Physiol Lung Cell Mol Physiol 293:L472-9. 2007Although one of the common characteristics of pulmonary hypertension is abnormal sustained vasoconstriction, the signaling pathways that mediate this heightened pulmonary vascular response are still not well defined...
- Estrogen replacement increases matrix metalloproteinase contribution to vasoconstriction in a rat model of menopauseOlga Lekontseva
Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Hypertens 27:1602-8. 2009..We hypothesized that MMPs are downstream mediators of vascular dysfunction in aging/estrogen deficiency...
- Inorganic arsenite potentiates vasoconstriction through calcium sensitization in vascular smooth muscleMoo-Yeol Lee
College of Pharmacy, Seoul National University, Seoul, Korea
Environ Health Perspect 113:1330-5. 2005..Treatment with arsenite, a trivalent inorganic species, increased vasoconstriction induced by phenylephrine or serotonin in a concentration-dependent manner...
- Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperatureJoo Lee Cham
School of Medical Sciences, Royal Melbourne Institute of Technology University, Melbourne, Victoria, Australia
Am J Physiol Renal Physiol 294:F309-15. 2008..The data suggest that the PVN plays an essential role in the reflex decrease in renal blood flow elicited by hyperthermia...
- Vasopressin-induced vasoconstriction: two concentration-dependent signaling pathwaysKyle K Henderson
Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Maywood, Illinois 60153, USA
J Appl Physiol 102:1402-9. 2007..However, half-maximal activation of PLC requires nanomolar concentrations of AVP, whereas vasoconstriction occurs when circulating concentrations of AVP are orders of magnitude lower...
- Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathwaysTsutomu Michibayashi
Clinical Pathophysiology, Division of Human Comprehensive Medicine, Graduate School of Medicine, Sapporo Medical University, Sapporo, Japan
J Atheroscler Thromb 12:154-62. 2005..b>Vasoconstriction was examined in perfused artery segments dissected from the central ear artery of male rabbits...
- Rho kinase-mediated vasoconstriction in pulmonary hypertensionIvan F McMurtry
Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA
Adv Exp Med Biol 661:299-308. 2010Rho kinase-mediated vasoconstriction rather than fixed arterial wall thickening is responsible for increased pulmonary vascular resistance and pulmonary hypertension in chronically hypoxic and monocrotaline-injected rats...
- Role of endothelial dysfunction in atherosclerosisJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
Circulation 109:III27-32. 2004..Studies have elucidated several possible mechanisms by which statin therapy may improve endothelial dysfunction, including upregulation of nitric oxide production or activity and reduction of oxidative stress...
- Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive ratsVirak Mam
Division of Vascular Surgery, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Pharmacol Exp Ther 332:455-62. 2010..We tested whether PH involves abnormal pulmonary vasoconstriction and impaired vasodilation...
- Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinaseEtto C Eringa
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 26:274-80. 2006..To investigate whether TNF-alpha directly impairs insulin-mediated vasoreactivity in skeletal muscle resistance arteries and the role of c-Jun N-terminal kinase (JNK) in this interference...
- Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entryGavin D Thomas
Department of Asthma, Allergy and Respiratory Science, GKT School of Medicine, King's College London, Guy's Campus, London SE1 9RT, UK
Cardiovasc Res 68:56-64. 2005..RESULTS: SPC induced a slow but powerful vasoconstriction in IPA associated with an elevation in [Ca2+]i, with an EC50 for vasoconstriction of 12+/-2 microM...
- Chronic hyperinsulinemia enhances adrenergic vasoconstriction and decreases calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed ratsShingo Takatori
Department of Clinical Pharmacy, School of Pharmacy, Shujitsu University, Okayama, Japan
Hypertens Res 29:361-8. 2006..These results suggest that chronic hyperinsulinemia in FDR facilitates adrenergic nerve-mediated vasoconstriction, which is associated with attenuated CGRPergic nerve-mediated vasodilation.
- Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanismsFabiano E Xavier
Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
J Hypertens 27:1233-42. 2009..We analyzed the effect of chronic ouabain (approximately 8.0 microg/day, 5 weeks) treatment on the blood pressure of spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats and the contribution of vascular mechanisms...
- Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive ratsM H Abdulla
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia
Acta Physiol (Oxf) 195:397-404. 2009..This study investigated the influence of angiotensin II (Ang II) receptor and adrenergic blockade on the renal vasoconstrictions caused by Ang II and adrenergic agonists in spontaneously hypertensive rats (SHR)...
- Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agentsValeria Camarda
Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, via Fossato di Mortara 17, 44100 Ferrara, Italy
Naunyn Schmiedebergs Arch Pharmacol 365:141-9. 2002..The rat aorta appears however to be a sensitive and reliable preparation for evaluating biological activities of hU-II and related peptides...
- Altered pulmonary vasoreactivity in the chronically hypoxic lungL A Shimoda
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine Baltimore, Maryland 21224, USA
Physiol Res 49:549-60. 2000....
- Capacitative calcium entry: a central role in hypoxic pulmonary vasoconstriction?Jeremy P T Ward
Am J Physiol Lung Cell Mol Physiol 289:L2-4. 2005
- Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertensionHarish Vasudevan
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3 Canada
Am J Physiol Heart Circ Physiol 291:H3058-64. 2006..In summary, testosterone is essential in vivo for the development of endothelial dysfunction and hypertension secondary to insulin resistance, suggesting a facilitatory role for testosterone in increasing BP in fructose-fed male rats...
- Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout ratA Elizabeth Linder
Dept of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 1317, USA
Am J Physiol Heart Circ Physiol 294:H1745-52. 2008....
- Vascular reactivity and endothelial NOS activity in rat thoracic aorta during and after hyperbaric oxygen exposureJonas Hink
Hyperbaric Oxygen Treatment Unit 4092 Dept of Anaesthesia, The Centre of Head and Orthopaedics, Copenhagen Univ Hospital Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen OE, Denmark
Am J Physiol Heart Circ Physiol 291:H1988-98. 2006..In addition, HBO increases the resting tone of rat aortic rings and attenuates the contractile response to norepinephrine by endothelium-independent mechanisms that involve extraendothelial NO production...
- Basal tonic release of nitric oxide coupled to cGMP production regulates the vascular reactivity of the mesenteric bedS Buvinic
, , MIFAB, , Casilla 114-D, Santiago, Chile
Eur J Pharmacol 424:221-7. 2001..The present results highlight a tonic release of NO and its involvement in endothelial-smooth muscle signaling; NO and cGMP are determinants of vascular reactivity...
- Lupin protein attenuates the development of hypertension and normalises the vascular function of NaCl-loaded Goto-Kakizaki ratsT K Pilvi
Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
J Physiol Pharmacol 57:167-76. 2006..The attenuation of hypertension is likely to be mediated by the corrected vascular dysfunction, whose precise mechanism and the possible clinical relevance remains to be studied further...
- Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic ringsA Galindo
, Facultad de Medicina, Universidad de Murcia, Espinardo-Murcia, Spain
Eur J Pharmacol 428:269-75. 2001..Our results demonstrate a functional and biochemical synergistic interaction of diazepam with cyclic AMP-elevating agents on rat aortic rings...
- Inhibitory effects of melatonin on vascular reactivity: possible role of vasoactive mediatorsM M Anwar
Physiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt
Comp Biochem Physiol C Toxicol Pharmacol 130:357-67. 2001..MEL inhibits the contractile responses of aortic rings to NA and PHE. These effects may be, in part, due to re-balancing the pro-oxidant/antioxidants system, lowered calcium content and elevated NO and cGMP levels in vascular tissue...
- Reduced plasma volume and mesenteric vascular reactivity in obese Zucker ratsAnn M Schreihofer
Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
Am J Physiol Regul Integr Comp Physiol 288:R253-61. 2005..These data suggest that systemic adrenergic pressor reactivity is not enhanced in OZR, despite exaggerated vascular reactivity in the hindlimb of the OZR...
- The influence of nitric oxide on tumour vascular toneG M Tozer
Tumour Microcirculation Group, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, England
Acta Oncol 34:373-7. 1995..However, under phenylephrine-induced vasoconstriction, sodium nitroprusside induced vasodilation whilst acetylcholine induced a small vasoconstriction...
- Circulatory Dysfunction in Chronic Fatigue SyndromeJulian Stewart; Fiscal Year: 2004..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura V Gonzalez Bosc; Fiscal Year: 2010..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura Gonzalez Bosc; Fiscal Year: 2009..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000gROBIN BRITT KNOBEL; Fiscal Year: 2010..We will examine the ability of each infant to exhibit peripheral vasoconstriction in response to decreased abdominal skin temperature and to keep abdominal temperature higher than peripheral ..
- Local Vasoconstriction in Postural Tachycardia SyndromeJulian M Stewart; Fiscal Year: 2010..One type of "Low flow POTS" (LFP) has increased vasoconstriction associated with increased angiotensin-II (Ang- II), reduced nitric oxide (NO), and increased reactive oxygen ..
- Local Calcium Signaling in Pulmonary ArteriesJAMES SK SHAM; Fiscal Year: 2010..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs;and these ..
- Local Calcium Signaling in Pulmonary ArteriesJAMES SHAM; Fiscal Year: 2009..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs; and these ..
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura Gonzalez Bosc; Fiscal Year: 2009..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- Oxidant Stress Mechanisms in PreeclampsiaScott W Walsh; Fiscal Year: 2010..Neutrophils infiltrating the vasculature could cause inflammation and vasoconstriction by release of toxic compounds, such as reactive oxygen species (ROS), TNF??and thromboxane...
- Age and Control of Human Skin FlowW Larry Kenney; Fiscal Year: 2010..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
- Age and Control of Human Skin FlowW Kenney; Fiscal Year: 2009..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
- ACETAMINOPHEN VS IBUPROFEN ON RENAL FUNCTION DURING EXERCISEW Kenney; Fiscal Year: 1999..resting conditions, PG inhibition with an NSAID has no appreciable effect on renal function because basal vasoconstriction tone is low. However, during exercise, there is both neural and endocrine stimuli (i.e...
- O2 sensing in the human and rabbit ductus arteriosusStephen L Archer; Fiscal Year: 2010..At birth, functional closure of the DA is initiated within minutes by O2-induced vasoconstriction. Functional closure (vasoconstriction) stops right to left shunting of blood and promotes anatomical closure...
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2007..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
- Renal Control of Blood Pressure in Early DiabetesMichael Brands; Fiscal Year: 2007We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
- Renal Vascular Reactivity in HypertensionWilliam J Arendshorst; Fiscal Year: 2011..angiotensin II (Ang II)-induced hypertension (AIH) and that CD38-deficient mice exhibit less pronounced renal vasoconstriction, Na+ retention and AIH than do wild-type (WT) mice...
- Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.Nancy Kanagy; Fiscal Year: 2007..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
- Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.Nancy L Kanagy; Fiscal Year: 2010..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
- Aging, Sex, and Neural Cardiovascular Control During Dynamic ExercisePAUL FADEL; Fiscal Year: 2009..Furthermore, since augmented sympathetically-mediated vasoconstriction would not only cause an elevation in BP but may also limit blood flow to active muscle, aim 2 is designed to ..
- TRP Channel-Dependent Regulation of Arterial ToneScott Earley; Fiscal Year: 2009..of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization...
- Tyrosine Kinases in Renal Vasoconstrictor SignalingPAMELA CARMINES; Fiscal Year: 2007..The primary Na+ retaining hormone, angiotensin II (AngII) elicits preglomerular (and postglomerular) vasoconstriction via engagement of AT1 receptors (AT1R), which provoke G protein-mediated phospholipase C (PLC) activation and ..
- PULMONARY MICROCIRCULATORY HEMODYNAMICSWILTZ WAGNER; Fiscal Year: 1999..largely passive circuit which, nevertheless, is capable of balancing perfusion to ventilation by hypoxic vasoconstriction. With regard to the hemodynamics of the actual gas exchange vessels, however, there are many unexplored areas ..
- Local Vasoconstriction in Postural Tachycardia SyndromeJulian Stewart; Fiscal Year: 2007..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
- Fibrinogen-induced vasoconstriction during hypertensionDavid Lominadze; Fiscal Year: 2009..We reported that binding of Fg to the arterial wall causes vasoconstriction, which is mediated by intercellular adhesion molecule-1 (ICAM-1)...
- INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROLSTEVEN SEGAL; Fiscal Year: 1999..flow; conducted (but not localized) vasodilation increases microvascular perfusion and attenuates sympathetic vasoconstriction. Nevertheless, the signal(s) which underlie conduction are unknown...
- Redistribution of pulmonary perfusion during bronchoconstriction in asthmaROBERT SCOTT HARRIS; Fiscal Year: 2010..are 1) The redistribution of perfusion away from ventilation defects is primarily caused by hypoxic pulmonary vasoconstriction and is not solely an artifact of methacholine-induced bronchoconstriction and 2) For a given degree of ..
- Arterial Baroreflex Control of Blood Pressure (Exercise)Peter Raven; Fiscal Year: 2006..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
- CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICSAlan Stephenson; Fiscal Year: 2002..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...