vasoconstriction

Summary

Summary: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.

Top Publications

  1. ncbi Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
  2. pmc Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
    Y J Gao
    Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 151:323-31. 2007
  3. ncbi Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    Masahiko Oka
    Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 100:923-9. 2007
  4. ncbi Transcranial color doppler study for reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Ann Neurol 63:751-7. 2008
  5. pmc SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
    Sung Sen Yang
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Am Soc Nephrol 21:1868-77. 2010
  6. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
  7. ncbi Hypoxic pulmonary vasoconstriction
    J T Sylvester
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
    Physiol Rev 92:367-520. 2012
  8. ncbi Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function
    Tommaso Gori
    Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Siena, Italy
    J Am Coll Cardiol 51:1953-8. 2008
  9. pmc Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction
    Liming Wang
    The Keenan Research Centre at Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Invest 122:4218-30. 2012
  10. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006

Detail Information

Publications384 found, 100 shown here

  1. ncbi Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
    Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without ..
  2. pmc Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
    Y J Gao
    Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 151:323-31. 2007
    ..Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated...
  3. ncbi Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    Masahiko Oka
    Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 100:923-9. 2007
    Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH)...
  4. ncbi Transcranial color doppler study for reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Ann Neurol 63:751-7. 2008
    Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published.
  5. pmc SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
    Sung Sen Yang
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Am Soc Nephrol 21:1868-77. 2010
    ..In summary, SPAK-null mice have defects of NCC in the kidneys and NKCC1 in the blood vessels, leading to hypotension through renal salt wasting and vasodilation. SPAK may be a promising target for antihypertensive therapy...
  6. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
    ..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
  7. ncbi Hypoxic pulmonary vasoconstriction
    J T Sylvester
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
    Physiol Rev 92:367-520. 2012
    It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung...
  8. ncbi Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function
    Tommaso Gori
    Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Siena, Italy
    J Am Coll Cardiol 51:1953-8. 2008
    ..We describe and validate a novel noninvasive method that complements the data from "traditional" flow-mediated dilation (FMD) studies...
  9. pmc Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction
    Liming Wang
    The Keenan Research Centre at Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Invest 122:4218-30. 2012
    Hypoxic pulmonary vasoconstriction (HPV) is a physiological mechanism by which pulmonary arteries constrict in hypoxic lung areas in order to redirect blood flow to areas with greater oxygen supply...
  10. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
    ..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
  11. pmc Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 103:19093-8. 2006
    Regional alveolar hypoxia causes local vasoconstriction in the lung, shifting blood flow from hypoxic to normoxic areas, thereby maintaining gas exchange. This mechanism is known as hypoxic pulmonary vasoconstriction (HPV)...
  12. ncbi Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels
    Seong Ho Ok
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea
    Anesthesiology 114:293-301. 2011
    ....
  13. ncbi Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage
    Carmine Vecchione
    Department of AngioCardioNeurology, Neuromed Institute IRCCS, Pozzilli, Italy
    Hypertension 54:150-6. 2009
    ..both in blood and in vascular tissues, where it provokes Rac-1/NADPH oxidase-mediated oxidative stress and vasoconstriction. Furthermore, we extended our observations to cerebral vessels, demonstrating that tumor necrosis factor-..
  14. pmc Quercetin protects against diabetes-induced exaggerated vasoconstriction in rats: effect on low grade inflammation
    Mona F Mahmoud
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    PLoS ONE 8:e63784. 2013
    ..Here, the effect of quercetin on diabetes-induced exaggerated vasoconstriction in insulin deficient and insulin resistant rat models was investigated...
  15. pmc Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
    J Biol Chem 285:39001-12. 2010
    ..Results suggest that DPTL blocks platelet aggregation, vasoconstriction, and angiogenesis through binding to distinct eicosanoids involved in inflammation.
  16. ncbi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009
    ..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
  17. ncbi Assessment of vascular function: flow-mediated constriction complements the information of flow-mediated dilatation
    T Gori
    Department of Medicine 2, University Hospital of Mainz, Mainz, Germany
    Heart 96:141-7. 2010
    ..To determine whether vascular function assessed by low-flow-mediated constriction (L-FMC), a novel non-invasive method, complements the information obtained with "traditional" flow-mediated dilatation (FMD)...
  18. pmc Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices
    Renate Paddenberg
    University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Respir Res 7:93. 2006
    Acute alveolar hypoxia causes pulmonary vasoconstriction (HPV) which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet...
  19. ncbi Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 87:835-41. 1997
    Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature...
  20. ncbi ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat
    Saema A S Beg
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 26:846-56. 2006
    ..Cerebral ischemia after SAH involves vasoconstriction and subsequent reduction in the CBF...
  21. ncbi The importance of endothelin-1 for vascular dysfunction in cardiovascular disease
    Felix Bohm
    Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden
    Cardiovasc Res 76:8-18. 2007
    ..Based on these observations and the biological effects induced by ET-1, including profound vasoconstriction, pro-inflammatory actions, mitogenic and proliferative effects, stimulation of free radical formation and ..
  22. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  23. ncbi Physiological roles of K+ channels in vascular smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University
    J Smooth Muscle Res 44:65-81. 2008
    ..The blockade of KATP channel function results in vasoconstriction and depolarization in various types of vascular smooth muscle...
  24. pmc Vascular plasticity in cerebrovascular disorders
    Lars I H Edvinsson
    Department of Clinical Experimental Research, Copenhagen University, Glostrup Hospital Research Park, Copenhagen, Denmark
    J Cereb Blood Flow Metab 31:1554-71. 2011
    ..Together, those findings provide new perspectives on the pathophysiology of ischemic stroke and point toward a novel way of reducing vasoconstriction, neuronal cell death, and thus neurologic deficits after stroke.
  25. ncbi Cerebral vasospasm: looking beyond vasoconstriction
    Jacob Hansen Schwartz
    Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK 2100, Denmark
    Trends Pharmacol Sci 28:252-6. 2007
    ..recently been challenged by the failure of the drug clazosentan to improve patient outcome, despite reversing vasoconstriction. In this article, we discuss the opinion that factors other than vasoconstriction are important in the ..
  26. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
  27. ncbi Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery
    Silvia Liskova
    Center of Cardiovascular Research and Institute of Physiology, Academy of Sciences of Czech Republic, Prague, Czech Republic
    Eur J Pharmacol 667:265-70. 2011
    ..We conclude that EDCF contribution to norepinephrine-induced contraction of conduit arteries is similarly enhanced in adult hypertensive and aged normotensive rats...
  28. pmc NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse
    Gilles Kauffenstein
    Centre de Recherche en Rhumatologie et Immunologie, Universite Laval, Quebec, QC, Canada G1V 4G2
    Cardiovasc Res 85:204-13. 2010
    ..The concentrations of these molecules are regulated by ectonucleotidases. In this study, we investigated the role of the blood vessel ectonucleotidase NTPDase1, in the vasoconstrictor effect of nucleotides using Entpd1(-/-) mice...
  29. ncbi Mild therapeutic hypothermia for postischemic vasoconstriction in the perfused rat liver
    H A Zar
    Safar Center for Resuscitation Research and the Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Anesthesiology 90:1103-11. 1999
    ....
  30. ncbi Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia
    E Kenneth Weir
    University of Minnesota, VA Medical Center 111C, One Veterans Drive, Minneapolis, MN 55417, USA
    Cardiovasc Res 71:630-41. 2006
    ..A better understanding of the pathophysiology of hypoxic pulmonary vasoconstriction and vascular remodeling will enable the design of better treatments for hypoxic and other forms of pulmonary ..
  31. ncbi Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model
    Qinghua Sun
    The Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 294:3003-10. 2005
    ..Recent studies have suggested a link between inhaled particulate matter exposure in urban areas and susceptibility to cardiovascular events; however, the precise mechanisms remain to be determined...
  32. ncbi Up-regulation of alpha1A-adrenoceptors in rat mesenteric artery involves intracellular signal pathways
    Yong xiao Cao
    Division of Experimental Vascular Research, Institution of Medicine, Lund University, Sweden
    Basic Clin Pharmacol Toxicol 98:61-7. 2006
    ..SB386023 did not affect alpha2-adrenoceptor mRNA level. Our results suggest that the up-regulation of alpha1A-adrenoceptors involves transcription and intracellular signal transduction via the protein kinase C and the ERK 1/2 pathways...
  33. ncbi Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesis
    Stuart I Myers
    McGuire Research Institute McGuire Veterans Administration Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    J Vasc Surg 44:383-91. 2006
    ....
  34. ncbi Reversible cerebral vasoconstriction in spontaneous intracranial hypotension
    Wouter I Schievink
    Headache 47:284-7. 2007
    ..Spontaneous intracranial hypotension should be considered in the differential diagnosis of reversible cerebral vasoconstriction.
  35. pmc Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 109:1493-500. 2002
    ..To assess the role of cPLA(2) in hypoxic pulmonary vasoconstriction (HPV), we measured the increase in left lung pulmonary vascular resistance (LPVR) before and during hypoxia ..
  36. ncbi Modulation of vein function by perivascular adipose tissue
    Chao Lu
    Smooth Muscle Research Program and Department of Anesthesia, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 657:111-6. 2011
    ..We conclude that venous PVAT attenuates agonist-induced contraction by releasing Ang-(1-7), which causes relaxation of smooth muscle through endothelial NO release and activation of K(v) channels...
  37. ncbi Isolated thunderclap headache during sex: Orgasmic headache or reversible cerebral vasoconstriction syndrome?
    Chih Ming Hu
    Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan
    J Clin Neurosci 17:1349-51. 2010
    ..Historically, it was considered benign with no treatment needed. Reversible cerebral vasoconstriction syndrome (RCVS) refers to a group of disorders characterized by recurrent thunderclap headache (TCH) and ..
  38. ncbi Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
    Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction, remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary vascular resistance in PAH...
  39. ncbi Iodinated contrast media cause endothelial damage leading to vasoconstriction of human and rat vasa recta
    Mauricio M Sendeski
    Institut fuer Vegetative Physiologie, Charite Universitaetzsmedizin Berlin, Berlin, Germany
    Am J Physiol Renal Physiol 303:F1592-8. 2012
    ..Again, adremonedullin reduced the CM effect. Our study suggests that the constrictor effect of CM on the renal medullary microvasculature is a consequence of endothelial cell damage and the resulting endothelial dysfunction...
  40. ncbi Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase
    Chi Yung Yuen
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Cardiovasc Res 90:122-9. 2011
    ....
  41. ncbi The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow
    Ivan B Lobov
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
    Blood 117:6728-37. 2011
    ..Modulation of VEGF-A and Dll4/Notch signaling produced distinct changes in blood vessel morphology and gene expression, indicating that these pathways can have largely independent functions in vascular remodeling...
  42. ncbi Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow
    Julian M Stewart
    Department of Pediatrics, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 291:H904-13. 2006
    ..and hyperemia occurred in both POTS groups compared with controls, marked enhancement in peripheral vasoconstriction occurred only in POTS(HC) and was related to thoracic blood flow...
  43. pmc High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats
    Dong You
    INSERM Unit 541, AP HP Hôpital Lariboisière, Paris, France
    Circulation 111:1006-11. 2005
    ....
  44. ncbi A role for Rho kinase in vascular contraction evoked by sodium fluoride
    Su Bun Jeon
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu 700 422, Republic of Korea
    Biochem Biophys Res Commun 343:27-33. 2006
    ..These results indicate that activation of Rho-kinase and the subsequent phosphorylation of MYPT1(Thr696) play important roles in NaF-induced contraction of rat aortae...
  45. pmc Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
    Anthony J Donato
    Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 579:115-25. 2007
    ..Vasodilator responses to isoproterenol and forskolin were also determined. Results: Noradrenaline-mediated vasoconstriction was increased in SOL arterioles with ageing, and exercise training in old rats attenuated alpha-adrenergic ..
  46. pmc Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 56:879-84. 2010
    ..These data suggest that IL-6-dependent activation of the renal janus kinase 2/signal transducer and activator of transcription 3 pathway plays a role in Ang II hypertension but not by mediating the effect of Ang II to decrease total RBF...
  47. ncbi Chronic HgCl(2) treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation
    Javier Blanco-Rivero
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Clin Sci (Lond) 121:331-41. 2011
    ..These findings offer further evidence that mercury, even at low concentrations, is an environmental risk factor for cardiovascular disease...
  48. ncbi Physiological regulation of penile arteries and veins
    D Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 20:17-29. 2008
    ..Sympathetic nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own ..
  49. pmc Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species
    Lorena B Furieri
    Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Madrid, Spain
    Br J Pharmacol 162:1819-31. 2011
    ..Exposure to mercury is known to increase cardiovascular risk but the underlying mechanisms are not well explored. We analysed whether chronic exposure to low mercury doses affects endothelial modulation of the coronary circulation...
  50. pmc Cellular signaling and potential new treatment targets in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Exp Diabetes Res 2007:31867. 2007
    ..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
  51. pmc Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin
    Pascale Gluais
    Institut de Recherches Servier, 92150 Suresnes, France
    Br J Pharmacol 146:834-45. 2005
    ..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
  52. ncbi Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
    Sean J Mulligan
    Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Nature 431:195-9. 2004
    ..b>Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF.
  53. pmc Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in mice
    Mohd Shahid
    Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 295:F1836-44. 2008
    ..1 microg.g(-1).min(-1); n = 6) resulted in further enhancement in vasoconstriction while natriuresis remained unaffected in response to TNF-alpha...
  54. pmc Acute oxygen-sensing mechanisms
    E Kenneth Weir
    Department of Medicine, Minneapolis Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA
    N Engl J Med 353:2042-55. 2005
  55. ncbi Pulse pressure, aortic reactivity, and endothelium dysfunction in old hypertensive rats
    P Chamiot-Clerc
    Medical Research Department, CNRS ESA 8078, Marie Lannelongue Hospital, 92350 Le Plessis-Robinson, France
    Hypertension 37:313-21. 2001
    ....
  56. ncbi Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase
    Keiji Oi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 24:918-22. 2004
    ..In this study, we examined whether RLP from patients with SCD upregulate Rho-kinase associated with an enhanced coronary vasospastic activity...
  57. ncbi Neurogenic nitric oxide release increases in mesenteric arteries from ouabain hypertensive rats
    Fabiano E Xavier
    Departamentos de Fisiología and Farmacología y Terapéutica, Facultad de Medicina, Universidad Autonoma, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    J Hypertens 22:949-57. 2004
    ..We investigated whether chronic ouabain treatment changes the vasoconstrictor responses induced by electrical field stimulation (EFS) in endothelium-denuded rat superior mesenteric arteries and a possible role of neuronal nitric oxide (NO)...
  58. ncbi Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent
    Ji Seok Baik
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea
    Can J Physiol Pharmacol 89:467-76. 2011
    Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels...
  59. ncbi Vasoconstrictor prostanoids
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Pflugers Arch 459:941-50. 2010
    ..TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation...
  60. ncbi Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Hypertension 39:825-9. 2002
    ..Although similarities were observed for large and small arteries, differences under the condition of DOCA-salt hypertension exist that may determine serotonergic compounds effective in lowering blood pressure...
  61. ncbi Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted
    J S Morton
    Department of Obstetrics, 232 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R930-8. 2010
    ..A change in the mechanisms of vasodilation occurring at an earlier age in IUGR offspring may predispose them to adult cardiovascular diseases...
  62. pmc Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:563-74. 2009
    ..Nevertheless, because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium-dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes...
  63. ncbi Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration
    Domniki N Papadopoulou
    Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
    Ophthalmology 116:1755-61. 2009
    ..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
  64. ncbi Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 106:1349-54. 2002
    ..We tested the hypothesis that this is due to a reduction in postjunctional alpha-adrenergic responsiveness to endogenous norepinephrine (NE) release and determined whether this was specific to alpha1- or alpha2-adrenergic receptors...
  65. ncbi Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet
    Christopher Torrens
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
    Br J Nutr 101:27-33. 2009
    ..b>Vasoconstriction to endothelin was significantly enhanced in all groups compared with controls (-log effective concentration ..
  66. pmc Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  67. ncbi Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction
    S S McDaniel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
    Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001
    ..These results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction...
  68. ncbi Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
  69. ncbi Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat
    Teddy Bagnost
    Laboratory of Physiology, Pharmacology, Experimental Preventive Nutrition, EA 3921, Cellular and Metabolic Optimization, Faculty of Medicine and Pharmacy, Besancon University Hospital, Besancon, France
    J Hypertens 26:1110-8. 2008
    ..The present study investigated the effects of in-vivo arginase inhibition on blood pressure and vascular function in adult spontaneously hypertensive rats...
  70. ncbi Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
    J M Launay
    CR C Bernard Pathologie expérimentale et communications cellulaires, IFR6, Services de Biochimie et d Angio Hématologie, Hôpital Lariboisière AP HP, Paris, France
    Nat Med 8:1129-35. 2002
    ..These data show that activation of 5-HT(2B) receptors is a limiting step in the development of pulmonary hypertension...
  71. ncbi Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat
    Marie Henriksson
    Division of Experimental Vascular Research, Lund University Hospital, Wallenberg Neurocentrum, BMC A13, 221 84 Lund, Sweden
    Stroke 34:1479-83. 2003
    ..The aim of this study was to examine the upregulation of contractile ETB receptors in cerebral arteries after organ culture and to elucidate the intracellular pathways involved...
  72. ncbi Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries
    S R Bailey
    Davis Heart and Lung Research Institute, R 110E, The Ohio State Univ, 473 West 12th Ave, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 289:H243-50. 2005
    ..NAC; 20 mmol/l), or the cell-permeable mimic of superoxide dismutase MnTMPyP (50 micromol/l) did not affect vasoconstriction to alpha2-AR stimulation (UK-14304) at 37 degrees C but dramatically inhibited the response at 28 degrees C...
  73. ncbi Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature
    Dexter L Lee
    Department of Physiology, Medical College of Georgia, Augusta 30912 3000, USA
    Hypertension 44:796-9. 2004
    ..This brief review will highlight recent studies demonstrating a role for the RhoA/Rho-kinase signaling pathway in the increased vasoconstriction characteristic of hypertension.
  74. ncbi Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring
    Silvia O Rocha
    Department of Physiology, Federal University of Sao Paulo, Brazil
    Pediatr Res 58:1274-9. 2005
    ....
  75. ncbi Ginger lowers blood pressure through blockade of voltage-dependent calcium channels
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    J Cardiovasc Pharmacol 45:74-80. 2005
    ..These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels...
  76. ncbi Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition
    Vaclav Hampl
    Department of Physiology, Charles University Second Medical School, 15000 Prague 5, Czech Republic
    Am J Physiol Heart Circ Physiol 283:H2440-9. 2002
    ..matching in the placenta, necessary for optimal fetal blood oxygenation, may occur via hypoxic fetoplacental vasoconstriction (HFPV)...
  77. ncbi Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: a case report
    Laura R Collins
    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Matern Fetal Neonatal Med 17:417-21. 2005
    b>Vasoconstriction was observed in the fetal middle cerebral and umbilical arteries by Doppler assessment at 27 weeks gestation in a patient requiring continuous morphine infusion for pain control. Fetal heart tracings were also concerning...
  78. pmc Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
    Jun Maki
    Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 159:919-27. 2010
    ..Thrombin may thus play an important role in the pathogenesis and pathophysiology of PAH. Hence, we investigated the contractile effects of thrombin and its mechanism in pulmonary artery...
  79. pmc Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine
    M A Anwar
    Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    Br J Pharmacol 165:2191-202. 2012
    Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the resistance arteries...
  80. ncbi Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis
    Mei Tsz Su
    Division of Genetics, Department of Obstetrics and Gynecology, National Cheng Kung University College of Medicine, 138 Sheng Li Road, Tainan 704, Taiwan
    Hum Reprod Update 17:803-12. 2011
    ..Some studies have reported angiogenesis- and vasoconstriction-related genes are associated with recurrent pregnancy loss (RPL), but their sample size was limited...
  81. pmc Obesity and risk of vascular disease: importance of endothelium-dependent vasoconstriction
    Matthias Barton
    Molecular Internal Medicine, University of Zurich, Zurich, Switzerland
    Br J Pharmacol 165:591-602. 2012
    ..Obesity results in an imbalance between endothelium-derived vasoactive factors favouring vasoconstriction, cell growth and inflammatory activation...
  82. ncbi Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion
    Brian Malester
    Department of Pediatrics, NYU School of Medicine, 560 First Ave, New York, NY 10016, USA
    FASEB J 21:2162-72. 2007
    ..These data are consistent with a role for endothelial K(ATP) channels to control the coronary blood flow by modulating the release of the vasoconstrictor, endothelin-1...
  83. ncbi Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition
    Hany M El-Bassossy
    Hypertension and Vascular Center, Wake Forest University Baptist Medical Center, Winston Salem, NC, 27157, USA
    Naunyn Schmiedebergs Arch Pharmacol 384:277-85. 2011
    ..Furthermore, TNF-α reduced ACh-induced NO generation, whereeas PTX restored it. In conclusion, PTX protects from the impairment in vascular reactivity in insulin resistance, by a mechanism involving TNF-α inhibition...
  84. ncbi Cinnamaldehyde protects from the hypertension associated with diabetes
    Hany M El-Bassossy
    Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt
    Food Chem Toxicol 49:3007-12. 2011
    ..In conclusion, CA prevents development of hypertension in insulin deficiency and insulin resistance through normalization of vascular contractility in addition to its insulinotropic effect in insulin deficiency...
  85. ncbi Effects of mental stress on coronary epicardial vasomotion and flow velocity in coronary artery disease: relationship with hemodynamic stress responses
    W J Kop
    Department of Medical and Clinical Psychology, Uniformed Services, University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Am Coll Cardiol 37:1359-66. 2001
    This study examines the prevalence and hemodynamic determinants of mental stress-induced coronary vasoconstriction in patients undergoing diagnostic coronary angiography.
  86. ncbi Hydrogen sulfide as an oxygen sensor/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation
    Kenneth R Olson
    Indiana University School of Medicine South Bend, 1234 Notre Dame Avenue, South Bend, IN 46617, USA
    J Exp Biol 209:4011-23. 2006
    How vertebrate blood vessels sense acute hypoxia and respond either by constricting (hypoxic vasoconstriction) or dilating (hypoxic vasodilation) has not been resolved...
  87. ncbi Aldosterone alters the participation of endothelial factors in noradrenaline vasoconstriction differently in resistance arteries from normotensive and hypertensive rats
    Fabiano E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    Eur J Pharmacol 654:280-8. 2011
    This study analyzed the effect of aldosterone (0.05mg/kg per day, 3 weeks) on vasoconstriction induced by noradrenaline in mesenteric resistance arteries from WKY rats and SHR...
  88. ncbi Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension
    Daryl O Schwenke
    Dept of Physiology, Univ of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 110:901-8. 2011
    Rho-kinase-mediated vasoconstriction and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH)...
  89. ncbi High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
    Kristen L Jablonski
    Dept of Integrative Physiology, Univ of Colorado, Boulder, CO 80309, USA
    J Appl Physiol 103:1715-21. 2007
    ..These results support the hypothesis that oxidative stress plays a major role in the reduced resting whole leg blood flow and increased leg vasoconstriction observed with aging in men.
  90. ncbi Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms
    N Sommer
    University of Giessen Lung Center, Medical Clinic II V, Justus Liebig University Giessen, Giessen, Germany
    Eur Respir J 32:1639-51. 2008
    Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler-Liljestrand mechanism, is a physiological response to alveolar hypoxia which distributes pulmonary capillary blood flow to alveolar areas of high oxygen partial ..
  91. ncbi Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism
    M Keith Wilkerson
    Dept of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Am J Physiol Heart Circ Physiol 288:H1652-61. 2005
    ..shifts and elevate arterial pressure, this study tested the hypothesis that 2-wk HDT enhances cerebral artery vasoconstriction and that an enhanced vasoconstriction described in vitro will alter regional cerebral blood flow (CBF) and ..
  92. pmc Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
    Hilda Ahnstedt
    Department of Clinical Sciences, Lund University, Sweden
    BMC Neurosci 12:5. 2011
    ..Contractile properties were evaluated in a myograph and protein expression of the individual receptors and activated phosphorylated B-Raf (p-B-Raf) was evaluated immunohistochemically...
  93. ncbi Role of thromboxane A₂-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of rat
    Hae Young Yoo
    Department of Physiology, Seoul National University College of Medicine Seoul, Korea
    Am J Physiol Cell Physiol 302:C307-17. 2012
    Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs...
  94. pmc Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes
    Maria Alícia Carrillo-Sepúlveda
    Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Professor Lineu Prestes 2415, Sao Paulo 05508 900, Brazil
    Cardiovasc Res 85:560-70. 2010
    ..We hypothesize that TH-induced rapid vascular relaxation is mediated by VSMC-derived nitric oxide (NO) production and is associated with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway...
  95. ncbi NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs
    N Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 280:L638-45. 2001
    Hypoxic pulmonary vasoconstriction (HPV) matches lung perfusion with ventilation but may also result in chronic pulmonary hypertension...
  96. ncbi Effect of ischemia duration and nitric oxide on coronary vasoconstriction after ischemia-reperfusion
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, Madrid 28029, Spain
    Eur J Pharmacol 509:165-70. 2005
    The effects of the duration of ischemia on coronary vasoconstriction after ischemia-reperfusion were analysed in rat hearts...
  97. ncbi Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure
    H R Middlekauff
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Appl Physiol (1985) 90:1714-9. 2001
    In heart failure (HF) patients, reflex renal vasoconstriction during exercise is exaggerated. We hypothesized that muscle mechanoreceptor control of renal vasoconstriction is exaggerated in HF...
  98. ncbi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..05 for all). ET-1 infusion increased plasma ET-1 concentrations by 58% (P<0.01) but caused vasoconstriction only after diesel exhaust exposure (-17% versus 2% after air; P<0.001)...
  99. ncbi Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling
    Dorota Dajnowiec
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Sci (Lond) 113:15-23. 2007
    ..Current efforts to define these signals and their targets may provide new directions for therapeutic interventions to treat important vascular disorders...
  100. ncbi NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
    Pharmacol Res 65:239-46. 2012
    ....
  101. ncbi Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection
    James A Brock
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, NSW 2031, Australia
    Am J Physiol Heart Circ Physiol 290:H398-405. 2006
    ..The findings provide further support for potentiated neurovascular responses contributing to the genesis of autonomic dysreflexia...

Research Grants76

  1. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following cardiopulmonary bypass and cardiac transplantation, but effective therapeutic strategies are ..
  2. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..CIN is mediated principally by CM-induced vasoconstriction of the afferent renal arteriololes, resulting in antidiuresis and severely compromised renal blood flow...
  3. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..PTH elevations has known deleterious physiological effects within the vasculature and myocardium such as vasoconstriction, activation of fibroblasts, insulin resistance, dyslipidemia, fat deposition and down regulation of ..
  4. Impaired mitochondrial fusion in pulmonary arterial hypertension
    Stephen L Archer; Fiscal Year: 2010
    ..arterial hypertension (PAH) is a syndrome characterized by obstructive vascular remodeling, inflammation and vasoconstriction of small pulmonary arteries. Despite recent therapeutic advances, 1-year mortality rates remains high (~15%)...
  5. UNDERSTANDING VIBRATION INJURY
    Danny A Riley; Fiscal Year: 2013
    ..the dose response of duration, frequency, acceleration and amplitude on the induction of persistent vasoconstriction in the rat-tail sinusoidal vibration model, Aim 2 To define the dose response relationship of shock wave ..
  6. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..of the renin-angiotensin system and augmented angiotensin receptor (AT1)-induced coronary microvascular vasoconstriction. Alterations in these mechanisms could significantly impair microvascular K+ channel function, in particular ..
  7. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs;and these ..
  8. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ..polypeptides activating G-protein-coupled receptors, NPY1R and NPY2R, to regulate satiety, metabolism, and vasoconstriction. Plasma NPY and PYY levels associate with eating and metabolic disorders, yet precise mechanisms underlying ..
  9. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    Endothelial dysfunction and platelet aggregation cause pulmonary artery vasoconstriction, mitogenesis, thrombosis, and vascular obliteration in pulmonary arterial hypertension (PAH) The recognition of abnormal eicosanoid metabolism and ..
  10. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    Pulmonary arterial hypertension (PAH) results from vasoconstriction and vascular remodeling. Our goal is to understand the role lung side population (SP) progenitor cells play in the development of hypobaric hypoxia- induced PAH...
  11. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..perfusion with L-NMMA +SNP, and after low dose phenylephrine as a control for baseline shifts of MSNA and vasoconstriction. L-NMMA enters the CNS slowly over many hours...
  12. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..is a lethal disorder characterized by pulmonary arterial remodeling, increased RVSP, chronic inflammation and vasoconstriction. The familial form of PAH is usually due to mutations in the type 2 receptor for Bone Morphogenic Protein, ..
  13. ATRIAL NATRIURETIC PEPTIDE AND RECEPTOR GENES IN HYPOXIA
    Yiu Fai Chen; Fiscal Year: 2010
    Hypoxic stress results in pulmonary vasoconstriction, hypertension and vascular remodeling, ultimately leading to right heart failure and death by upsetting the balance in the normal relationships between vasoconstrictor and vasodilator ..
  14. Vascular Mechanisms in Pregnancy-Induced Hypertension
    Raouf A Khalil; Fiscal Year: 2013
    ..Reduction in uterine perfusion pressure (RUPP) in late pregnant rats is associated with HTN, increased vasoconstriction and reduced relaxation...
  15. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..the most significant hurdle to the development of modified hemoglobin-based blood substitutes, namely vasoconstriction. MP4 promotes tissue oxygenation through a combination of O2 transport and maintenance of functional ..
  16. Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance
    SHAWN BRADY BENDER; Fiscal Year: 2013
    ..novel molecular mechanisms by which VSMC MR signaling promotes VSMC hypercontractility, increased coronary vasoconstriction and reductions in CFR associated with IR...
  17. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    ..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
  18. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..PH is characterized by vascular obstruction and variable presence of vasoconstriction, leading to a sustained increased pulmonary vascular resistance, vascular remodeling, right ventricular (RV) ..
  19. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2012
    ..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
  20. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Interestingly, the phenylephrine-induced vasoconstriction in the kidney is attenuated but the drop in blood pressure elicited by ganglion blockade is greater in MS ..
  21. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Interestingly, the phenylephrine-induced vasoconstriction in the kidney is attenuated but the drop in blood pressure elicited by ganglion blockade is greater in MS ..
  22. Endothelial Lipoxygenase Metabolites and Vascular Tone
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2013
    ..I2 and endothelium-derived hyperpolarizing factor (EDHF) that reduce vascular tone and counteract vasoconstriction. Ischemic heart disease, heart failure and hyperten- sion are associated with vasoconstriction that is ..
  23. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2013
    ..One type of "Low flow POTS" (LFP) has increased vasoconstriction associated with increased angiotensin-II (Ang- II), reduced nitric oxide (NO), and increased reactive oxygen ..
  24. Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cells
    Michael X Zhu; Fiscal Year: 2012
    ..other physiological systems, where TRPC4 and related TRPC5 channels are known to involve in functions such as vasoconstriction/relaxation, synaptic transmission, neurite outgrowth/neural development, and learning...
  25. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Calcineurin inhibitors cause intense vasoconstriction of renal vasculature, decreasing blood flow and function of the kidneys...
  26. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..However, physiological responses to forced cooling (shivering, vasoconstriction and release of stress hormones) reduce the efficacy of hypothermia...
  27. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..CO raises carboxyl- hemoglobin levels, whilst nicotine induces vasoconstriction, which further decreases tissue oxygenation. Smoking delays skeletal healing by 60% following fractures...
  28. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2011
    ..Although the role of ETAR in mediating vasoconstriction and hypertension (HTN) has been studied extensively, the role of ETBR in the regulation of vascular function ..
  29. NO-Zinc Signaling in Intact Pulmonary Endothelium
    CLAUDETTE MARIE ST CROIX; Fiscal Year: 2010
    Although hypoxic pulmonary vasoconstriction (HPV) has been reported to affect all segments of the pulmonary circulation relatively little is known regarding vasoconstriction of small (<50um) intra-acinar arterioles...
  30. Ecstasy and the Dorsomedial Hypothalamus
    Daniel E Rusyniak; Fiscal Year: 2010
    ..Ultimately activation of these systems causes hyperthermia, tachycardia, hypertension, and cutaneous vasoconstriction, effects which are amplified in a warm environment...
  31. Respiratory and Metabolic Adaptation to Hypoxia
    Paul T Schumacker; Fiscal Year: 2013
    ..the stabilization of Hypoxia-Inducible Factor-1 alpha (HIF-1a) and the activation of hypoxic pulmonary vasoconstriction. This aim will be tested by protein crystallization studies of intact Complex III under different O2 ..
  32. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..tissue perfusion may be inadequate, the arterial blood pressure may be in a normal range due to compensatory vasoconstriction. Despite their widespread use, no study has shown that use of these measures improves outcome, and reliance ..
  33. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..shivering in skeletal muscle and from a marked tachycardia and increased heat conservation through cutaneous vasoconstriction (CVC)...
  34. Physiological Regulation of MLCK in Intact Arteries
    Withrow Gil Wier; Fiscal Year: 2013
    ..FRET microscopy) of arteries in anesthetized biosensor animals to quantify the role of MLCK in the increased vasoconstriction that occurs in DOCA-salt hypertension...
  35. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..Further, TCDD increases arachidonic acid (AA)-mediated vasoconstriction and an ?-3 PUFA-enriched diet normalizes this effect...
  36. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    Endothelial cells (EC) release several factors that reduce vascular tone and counteract vasoconstriction including nitric oxide (NO) and prostaglandin (PG) I2...
  37. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2013
    ..Neutrophils infiltrating the vasculature could cause inflammation and vasoconstriction by release of toxic compounds, such as reactive oxygen species (ROS), TNF??and thromboxane...
  38. Natriuretic mechanisms of AT2 receptors
    ROBERT MUNSON CAREY; Fiscal Year: 2010
    ..The vast majority of Ang II actions are mediated by the AT1 receptor, including cell proliferation, vasoconstriction and antinatriuresis. Much less is known concerning the functions of the AT2 receptor...
  39. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..Acute PE also causes vasoconstriction that increases pulmonary vascular resistance (PVR)...
  40. Vascular Phenotypic Regulation by Growth Factors, Insulin and Glucose
    Lakshman Segar; Fiscal Year: 2011
    ..transport and insulin signaling and its functional consequences in conduit vessel neointimal growth and vasoconstriction. This aim will utilize venous vs arterial grafts from nondiabetic and diabetic patients to determine how ..
  41. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..Indeed, high altitude gestation and birth exaggerates hypoxia induced pulmonary vasoconstriction in 2 week old sheep and results in significant penetration of pulmonary hypertension...
  42. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..fiber sensory nerves, which in turn activate the sympathetic nervous system, an effect which in turn causes vasoconstriction in the heart, kidneys and the skeletal muscles...
  43. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..healthy adults and older moderate OSA patients;(2) we will determine whether local blockade of -adrenergic vasoconstriction and -adrenergic mediated vasodilation reduces the age- and disease-group differences in peripheral vascular ..
  44. PPAR gamma and Nox4 in pulmonary hypertension
    Roy L Sutliff; Fiscal Year: 2013
    ..Nox4 generates reactive oxygen species that contribute to vasoconstriction, pulmonary vascular cell proliferation, and PH pathogenesis...
  45. Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease
    David J Moser; Fiscal Year: 2012
    ..the relationships among oxidative stress-mediated suppression of vascular function, neurohumoral mediators of vasoconstriction (endothelin levels, indicators of renin-angiotensin- aldosterone system and sympathetic nervous system ..
  46. Calcium channels in arterial smooth muscle cells
    Jonathan H Jaggar; Fiscal Year: 2013
    ..2 channel regulation by 124 leads to an elevation in Cav1.2 currents and vasoconstriction. The overall goal of this application is to expand our knowledge of the molecular physiology of CaV1...
  47. Estrogen & Progesterone Effects on Orthostatic Tolerance
    NINA STACHENFELD; Fiscal Year: 2010
    ..with estradiol tending to increase peripheral vasodilation, and with progesterone tending to increase vasoconstriction. Moreover, estradiol has important effects on progesterone receptor function;thus the interaction of these ..
  48. Red Blood Cell S-nitrosothiols and Oxygenation
    Jonathan S Stamler; Fiscal Year: 2012
    ..in blood vessels where arterial pressure reflects operation of the physiological response, hypoxic pulmonary vasoconstriction (HPV)...
  49. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2013
    ..The vast majority of Ang II actions are mediated by the AT1 receptor, including cell proliferation, vasoconstriction and antinatriuresis. Much less is known concerning the functions of the AT2 receptor...
  50. Role of BK subunits in ethanol-cholesterol synergistic inhibition of BK channel
    Anna Bukiya; Fiscal Year: 2011
    ..high cholesterol levels in myocyte membrane also inhibit BK currents, decrease vascular compliance, favoring vasoconstriction. Cholesterol is proposed to amplify ethanol-driven BK channel inhibition, thus, ethanol and high cholesterol ..
  51. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..LT levels and potentially contribute to the progression of PAH, a disorder characterized by pulmonary vasoconstriction and vascular remodeling, by inducing vasoconstriction of the pulmonary vasculature...
  52. Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
    Andrea Baccarelli; Fiscal Year: 2013
    ..on DNA methylation (Aim 1), mRNA expression &plasma cytokines (Aim 2), and blood pressure, arterial vasoconstriction, endothelial function, and autonomic control of the heart (Aim 3)...
  53. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    Paul J Fadel; Fiscal Year: 2012
    ..Furthermore, since augmented sympathetically-mediated vasoconstriction would not only cause an elevation in BP but may also limit blood flow to active muscle, aim 2 is designed to ..
  54. Lead and Vascular Reactivity to Acute Stress in Children
    Brooks Gump; Fiscal Year: 2009
    ..and vascular reactivity is not clear, however, it is presumed to involve a number of systems that regulate vasoconstriction and vasodilation, including the kallikrein-kinin system (KKS), oxidative stress, the renin-angiotensin system ..
  55. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..AngII activates angiotensin type 1 receptor (AT1R) to induce vasoconstriction, and angiotensin type 2 receptor (AT2R) to induce the release of vasodilator substances and promote vascular ..
  56. The Role of Obesity and Adipocytes in Immune Activation on Antiretroviral Therapy
    John Koethe; Fiscal Year: 2013
    ..researcher in the field of vascular biology and hypertension, including the effects of activated T cells on vasoconstriction and sodium retention...
  57. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2013
    ..of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization...
  58. Renal Vascular Reactivity in Hypertension
    William J Arendshorst; Fiscal Year: 2013
    ..angiotensin II (Ang II)-induced hypertension (AIH) and that CD38-deficient mice exhibit less pronounced renal vasoconstriction, Na+ retention and AIH than do wild-type (WT) mice...
  59. Endothelin and Angiotensin Receptor Signaling in Pulmonary Hypertension
    PETER RUDOLPH POLGAR; Fiscal Year: 2013
    ..In human lung vascular smooth muscle cells (HLVSMC) ET-1 stimulates cell proliferation and vasoconstriction. In PH this homeostatic regulation breaks down...
  60. Vascular Smooth Muscle Function in Pulmonary Hypertension
    Nikki L Jernigan; Fiscal Year: 2013
    ..advance our knowledge of the cellular mechanisms responsible for altered PASMC Ca2+ homeostasis and vasoconstriction in the hypertensive pulmonary circulation...
  61. OXIDATIVE STRESS AND KIDNEY OXYGEN USAGE
    William J Welch; Fiscal Year: 2012
    ..stress contributes to the development of systemic hypertension by alterations in renal function, including vasoconstriction, increased solute and electrolyte retention and tubular dysfunction...
  62. The Role Gai2 Signaling in Hypertension
    Dennis W McGraw; Fiscal Year: 2012
    ..do not differ, this aim will focus on calcium sensitization as the primary mechanism by which G1i2 enhances vasoconstriction. Aim 3 will use transgenic mice that express a G1i2 inhibitory 'minigene'in VSM to determine ..
  63. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
  64. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ..We will examine the ability of each infant to exhibit peripheral vasoconstriction in response to decreased abdominal skin temperature and to keep abdominal temperature higher than peripheral ..
  65. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..The first section will examine clinically relevant amplifiers of arterial vasoconstriction, denudation and cholesterol in the presence of an arterial stenosis...
  66. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2002
    ..oxygen carrier for clinical use remains elusive, primarily because cell-free hemoglobin induces vasoconstriction and reduced tissue oxygenation...
  67. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..by applicant): We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  68. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..following fetal bypass and cardiac surgery share all the classic hallmarks of vasopressin mediated vasoconstriction: increased peripheral vasoconstriction, placental vascular resistance, and centralized fetal circulation, ..
  69. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
  70. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    Sandra L Pfister; Fiscal Year: 2010
    ..b>Vasoconstriction, vascular remodeling and thrombosis all contribute to the increased vascular resistance...
  71. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..It is believed that cocaine may cause cerebral vasoconstriction leading to intracranial hemorrhage or cerebral infarction...
  72. Mechanisms of MDMA-induced hyperthermia
    Edward Mills; Fiscal Year: 2009
    ..dramatic increase in "non-shivering" metabolic thermogenesis in the setting of heat conservation (peripheral vasoconstriction)...
  73. PERIANETHETIC TREMOR AND THERMOREGULATION
    Daniel Sessler; Fiscal Year: 1993
    ..anesthetic concentrations in the brain decrease rapidly, and normal compensation for hypothermia triggers vasoconstriction, shivering, and nonshivering thermogenesis...
  74. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 2000
    ..goal of this project is further understanding of the mechanisms underlying the exaggerated reflex renal vasoconstriction in humans with heart failure during exercise...
  75. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2006
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  76. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2002
    ..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...