vasoconstriction

Summary

Summary: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.

Top Publications

  1. ncbi Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
  2. pmc Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
    Y J Gao
    Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 151:323-31. 2007
  3. pmc Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries
    Salvatore Salomone
    Stroke and Neurovascular Laboratory Regulation, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Pharmacol Res 62:465-74. 2010
  4. ncbi Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    Masahiko Oka
    Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 100:923-9. 2007
  5. ncbi Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome
    U Deniz Dincer
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, USA
    Microcirculation 13:587-95. 2006
  6. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
  7. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
  8. pmc Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 103:19093-8. 2006
  9. ncbi Cerebral vasospasm: looking beyond vasoconstriction
    Jacob Hansen Schwartz
    Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK 2100, Denmark
    Trends Pharmacol Sci 28:252-6. 2007
  10. doi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009

Research Grants

Detail Information

Publications347 found, 100 shown here

  1. ncbi Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
    Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without ..
  2. pmc Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide
    Y J Gao
    Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 151:323-31. 2007
    ..Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated...
  3. pmc Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries
    Salvatore Salomone
    Stroke and Neurovascular Laboratory Regulation, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Pharmacol Res 62:465-74. 2010
    ..Basilar arteries from SPK1(-/-) mice exhibited weaker vasoconstriction to both KCl and agonists (S1P and the prostanoid U46619) when compared to either wild type (WT) or SPK2(-/-)...
  4. ncbi Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    Masahiko Oka
    Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 100:923-9. 2007
    Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH)...
  5. ncbi Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome
    U Deniz Dincer
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, USA
    Microcirculation 13:587-95. 2006
    This study tested whether alpha -adrenoceptor-mediated coronary vasoconstriction is augmented in the metabolic syndrome and is accompanied by the alteration of specific alpha(1)- and alpha(2)-coronary adrenoceptors.
  6. pmc Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling
    Monica R Metea
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 26:2862-70. 2006
    ..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
  7. ncbi A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    M Yanagisawa
    Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Nature 332:411-5. 1988
    ..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
  8. pmc Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 103:19093-8. 2006
    Regional alveolar hypoxia causes local vasoconstriction in the lung, shifting blood flow from hypoxic to normoxic areas, thereby maintaining gas exchange. This mechanism is known as hypoxic pulmonary vasoconstriction (HPV)...
  9. ncbi Cerebral vasospasm: looking beyond vasoconstriction
    Jacob Hansen Schwartz
    Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK 2100, Denmark
    Trends Pharmacol Sci 28:252-6. 2007
    ..recently been challenged by the failure of the drug clazosentan to improve patient outcome, despite reversing vasoconstriction. In this article, we discuss the opinion that factors other than vasoconstriction are important in the ..
  10. doi Endothelial dysfunction and vascular disease
    P M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Acta Physiol (Oxf) 196:193-222. 2009
    ..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
  11. pmc Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices
    Renate Paddenberg
    University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Respir Res 7:93. 2006
    Acute alveolar hypoxia causes pulmonary vasoconstriction (HPV) which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet...
  12. ncbi Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 87:835-41. 1997
    Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature...
  13. ncbi Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature
    Dexter L Lee
    Department of Physiology, Medical College of Georgia, Augusta 30912 3000, USA
    Hypertension 44:796-9. 2004
    ..This brief review will highlight recent studies demonstrating a role for the RhoA/Rho-kinase signaling pathway in the increased vasoconstriction characteristic of hypertension.
  14. ncbi The importance of endothelin-1 for vascular dysfunction in cardiovascular disease
    Felix Bohm
    Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden
    Cardiovasc Res 76:8-18. 2007
    ..Based on these observations and the biological effects induced by ET-1, including profound vasoconstriction, pro-inflammatory actions, mitogenic and proliferative effects, stimulation of free radical formation and ..
  15. ncbi Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage
    Saema Ansar
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
    Am J Physiol Heart Circ Physiol 293:H3750-8. 2007
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
  16. doi The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow
    Ivan B Lobov
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
    Blood 117:6728-37. 2011
    ..Modulation of VEGF-A and Dll4/Notch signaling produced distinct changes in blood vessel morphology and gene expression, indicating that these pathways can have largely independent functions in vascular remodeling...
  17. doi Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function
    Tommaso Gori
    Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Siena, Italy
    J Am Coll Cardiol 51:1953-8. 2008
    ..We describe and validate a novel noninvasive method that complements the data from "traditional" flow-mediated dilation (FMD) studies...
  18. pmc High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats
    Dong You
    INSERM Unit 541, AP HP Hôpital Lariboisière, Paris, France
    Circulation 111:1006-11. 2005
    ....
  19. ncbi A role for Rho kinase in vascular contraction evoked by sodium fluoride
    Su Bun Jeon
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu 700 422, Republic of Korea
    Biochem Biophys Res Commun 343:27-33. 2006
    ..These results indicate that activation of Rho-kinase and the subsequent phosphorylation of MYPT1(Thr696) play important roles in NaF-induced contraction of rat aortae...
  20. ncbi Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flow
    Julian M Stewart
    Department of Pediatrics, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
    Am J Physiol Heart Circ Physiol 291:H904-13. 2006
    ..and hyperemia occurred in both POTS groups compared with controls, marked enhancement in peripheral vasoconstriction occurred only in POTS(HC) and was related to thoracic blood flow...
  21. ncbi Hypoxic pulmonary vasoconstriction
    J T Sylvester
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
    Physiol Rev 92:367-520. 2012
    It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung...
  22. doi Chronic HgCl(2) treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervation
    Javier Blanco-Rivero
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    Clin Sci (Lond) 121:331-41. 2011
    ..These findings offer further evidence that mercury, even at low concentrations, is an environmental risk factor for cardiovascular disease...
  23. ncbi Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: a case report
    Laura R Collins
    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Matern Fetal Neonatal Med 17:417-21. 2005
    b>Vasoconstriction was observed in the fetal middle cerebral and umbilical arteries by Doppler assessment at 27 weeks gestation in a patient requiring continuous morphine infusion for pain control. Fetal heart tracings were also concerning...
  24. pmc Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
    Anthony J Donato
    Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
    J Physiol 579:115-25. 2007
    ..Vasodilator responses to isoproterenol and forskolin were also determined. Results: Noradrenaline-mediated vasoconstriction was increased in SOL arterioles with ageing, and exercise training in old rats attenuated alpha-adrenergic ..
  25. ncbi Physiological regulation of penile arteries and veins
    D Prieto
    Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Int J Impot Res 20:17-29. 2008
    ..Sympathetic nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own ..
  26. doi Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent
    Ji Seok Baik
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea
    Can J Physiol Pharmacol 89:467-76. 2011
    Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels...
  27. pmc Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation
    Michael W Brands
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
    Hypertension 56:879-84. 2010
    ..These data suggest that IL-6-dependent activation of the renal janus kinase 2/signal transducer and activator of transcription 3 pathway plays a role in Ang II hypertension but not by mediating the effect of Ang II to decrease total RBF...
  28. pmc Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species
    Lorena B Furieri
    Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Madrid, Spain
    Br J Pharmacol 162:1819-31. 2011
    ..Exposure to mercury is known to increase cardiovascular risk but the underlying mechanisms are not well explored. We analysed whether chronic exposure to low mercury doses affects endothelial modulation of the coronary circulation...
  29. doi Vasoconstrictor prostanoids
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Pflugers Arch 459:941-50. 2010
    ..TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation...
  30. ncbi Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
    Sean J Mulligan
    Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Nature 431:195-9. 2004
    ..b>Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF.
  31. pmc Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin
    Pascale Gluais
    Institut de Recherches Servier, 92150 Suresnes, France
    Br J Pharmacol 146:834-45. 2005
    ..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
  32. pmc Cellular signaling and potential new treatment targets in diabetic retinopathy
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Ontario, Canada
    Exp Diabetes Res 2007:31867. 2007
    ..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
  33. doi Transcranial color doppler study for reversible cerebral vasoconstriction syndromes
    Shih Pin Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Ann Neurol 63:751-7. 2008
    Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published.
  34. pmc Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in mice
    Mohd Shahid
    Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 295:F1836-44. 2008
    ..1 microg.g(-1).min(-1); n = 6) resulted in further enhancement in vasoconstriction while natriuresis remained unaffected in response to TNF-alpha...
  35. pmc SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
    Sung Sen Yang
    Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    J Am Soc Nephrol 21:1868-77. 2010
    ..In summary, SPAK-null mice have defects of NCC in the kidneys and NKCC1 in the blood vessels, leading to hypotension through renal salt wasting and vasodilation. SPAK may be a promising target for antihypertensive therapy...
  36. doi Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted
    J S Morton
    Department of Obstetrics, 232 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R930-8. 2010
    ..A change in the mechanisms of vasodilation occurring at an earlier age in IUGR offspring may predispose them to adult cardiovascular diseases...
  37. pmc Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:563-74. 2009
    ..Nevertheless, because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium-dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes...
  38. ncbi Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension
    Stephanie W Watts
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
    Hypertension 39:825-9. 2002
    ..Although similarities were observed for large and small arteries, differences under the condition of DOCA-salt hypertension exist that may determine serotonergic compounds effective in lowering blood pressure...
  39. ncbi Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration
    Domniki N Papadopoulou
    Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
    Ophthalmology 116:1755-61. 2009
    ..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
  40. pmc Vascular plasticity in cerebrovascular disorders
    Lars I H Edvinsson
    Department of Clinical Experimental Research, Copenhagen University, Glostrup Hospital Research Park, Copenhagen, Denmark
    J Cereb Blood Flow Metab 31:1554-71. 2011
    ..Together, those findings provide new perspectives on the pathophysiology of ischemic stroke and point toward a novel way of reducing vasoconstriction, neuronal cell death, and thus neurologic deficits after stroke.
  41. ncbi Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Circulation 106:1349-54. 2002
    ..We tested the hypothesis that this is due to a reduction in postjunctional alpha-adrenergic responsiveness to endogenous norepinephrine (NE) release and determined whether this was specific to alpha1- or alpha2-adrenergic receptors...
  42. doi Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet
    Christopher Torrens
    Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
    Br J Nutr 101:27-33. 2009
    ..b>Vasoconstriction to endothelin was significantly enhanced in all groups compared with controls (-log effective concentration ..
  43. doi Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat
    Teddy Bagnost
    Laboratory of Physiology, Pharmacology, Experimental Preventive Nutrition, EA 3921, Cellular and Metabolic Optimization, Faculty of Medicine and Pharmacy, Besancon University Hospital, Besancon, France
    J Hypertens 26:1110-8. 2008
    ..The present study investigated the effects of in-vivo arginase inhibition on blood pressure and vascular function in adult spontaneously hypertensive rats...
  44. ncbi ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat
    Saema A S Beg
    Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 26:846-56. 2006
    ..Cerebral ischemia after SAH involves vasoconstriction and subsequent reduction in the CBF...
  45. pmc Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats
    Xiao Lu
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Cardiovasc Diabetol 9:19. 2010
    ..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
  46. ncbi Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstriction
    S S McDaniel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
    Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001
    ..These results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction...
  47. ncbi Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
  48. ncbi Ginger lowers blood pressure through blockade of voltage-dependent calcium channels
    Muhammad Nabeel Ghayur
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
    J Cardiovasc Pharmacol 45:74-80. 2005
    ..These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels...
  49. ncbi Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspring
    Silvia O Rocha
    Department of Physiology, Federal University of Sao Paulo, Brazil
    Pediatr Res 58:1274-9. 2005
    ....
  50. ncbi Periadventitial fat releases a vascular relaxing factor
    Matthias Löhn
    HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    FASEB J 16:1057-63. 2002
    ..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
  51. doi Role of thromboxane A₂-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of rat
    Hae Young Yoo
    Department of Physiology, Seoul National University College of Medicine Seoul, Korea
    Am J Physiol Cell Physiol 302:C307-17. 2012
    Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs...
  52. ncbi Effect of ischemia duration and nitric oxide on coronary vasoconstriction after ischemia-reperfusion
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, Madrid 28029, Spain
    Eur J Pharmacol 509:165-70. 2005
    The effects of the duration of ischemia on coronary vasoconstriction after ischemia-reperfusion were analysed in rat hearts...
  53. ncbi NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs
    N Weissmann
    Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 280:L638-45. 2001
    Hypoxic pulmonary vasoconstriction (HPV) matches lung perfusion with ventilation but may also result in chronic pulmonary hypertension...
  54. pmc Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes
    Maria Alícia Carrillo-Sepúlveda
    Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Professor Lineu Prestes 2415, Sao Paulo 05508 900, Brazil
    Cardiovasc Res 85:560-70. 2010
    ..We hypothesize that TH-induced rapid vascular relaxation is mediated by VSMC-derived nitric oxide (NO) production and is associated with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway...
  55. ncbi Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesis
    Stuart I Myers
    McGuire Research Institute McGuire Veterans Administration Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
    J Vasc Surg 44:383-91. 2006
    ....
  56. pmc Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
    Hilda Ahnstedt
    Department of Clinical Sciences, Lund University, Sweden
    BMC Neurosci 12:5. 2011
    ..Contractile properties were evaluated in a myograph and protein expression of the individual receptors and activated phosphorylated B-Raf (p-B-Raf) was evaluated immunohistochemically...
  57. doi Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase
    Chi Yung Yuen
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Cardiovasc Res 90:122-9. 2011
    ....
  58. ncbi NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel
    Xiao Yu Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
    Pharmacol Res 65:239-46. 2012
    ....
  59. ncbi Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection
    James A Brock
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, NSW 2031, Australia
    Am J Physiol Heart Circ Physiol 290:H398-405. 2006
    ..The findings provide further support for potentiated neurovascular responses contributing to the genesis of autonomic dysreflexia...
  60. ncbi Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure
    H R Middlekauff
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Appl Physiol (1985) 90:1714-9. 2001
    In heart failure (HF) patients, reflex renal vasoconstriction during exercise is exaggerated. We hypothesized that muscle mechanoreceptor control of renal vasoconstriction is exaggerated in HF...
  61. ncbi Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling
    Dorota Dajnowiec
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Sci (Lond) 113:15-23. 2007
    ..Current efforts to define these signals and their targets may provide new directions for therapeutic interventions to treat important vascular disorders...
  62. doi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..05 for all). ET-1 infusion increased plasma ET-1 concentrations by 58% (P<0.01) but caused vasoconstriction only after diesel exhaust exposure (-17% versus 2% after air; P<0.001)...
  63. ncbi Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries
    G A Wiggers
    Departamento de Farmacologia, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain
    Am J Physiol Heart Circ Physiol 295:H1033-H1043. 2008
    ..59 ng/ml. Mercury treatment: 1) did not affect systolic blood pressure; 2) increased phenylephrine-induced vasoconstriction; 3) reduced acetylcholine-induced vasodilatation; and 4) reduced in aorta and abolished in MRA the increased ..
  64. ncbi Segmental cerebral vasoconstriction: successful treatment of secondary cerebral ischaemia with intravenous prostacyclin
    Per Olof Grände
    Department of Anaesthesiology and Intensive Care, Lund University and Lund University Hospital, Lund, Sweden
    Cephalalgia 30:890-5. 2010
    ..brain ischaemia and oedema within the left cerebral hemisphere with strict ipsilateral segmental arterial vasoconstriction. Despite extensive medical care, including steroids, the patient deteriorated rapidly...
  65. doi Pulmonary vascular involvement in COPD
    Victor I Peinado
    Department of Pulmonary Medicine, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Chest 134:808-14. 2008
    ..The safety and efficacy of endothelium-targeted therapy in COPD-associated pulmonary hypertension warrants further investigation in randomized clinical trials...
  66. pmc Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling
    Peter Pokreisz
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute of Biotechnology, University of Leuven, Belgium
    Hypertension 47:762-70. 2006
    ..the response (by 39%), indicating that CYP epoxygenase-derived epoxyeicosatrienoic acids elicit pulmonary vasoconstriction. Aerosol gene transfer of recombinant adenovirus containing the human CYP2C9 significantly elevated mean ..
  67. pmc Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction
    Matthias R Meyer
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Hypertension 59:507-12. 2012
    ..that nonselective estrogen receptor agonists such as endogenous estrogens inhibit endothelium-dependent vasoconstriction; however, the role of estrogen receptors in this response has not yet been clarified...
  68. ncbi Phenotypic modulation of cultured vascular smooth muscle cells: a functional analysis focusing on MLC and ERK1/2 phosphorylation
    M A Carrillo-Sepúlveda
    Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Sao Paulo, Brazil
    Mol Cell Biochem 341:279-89. 2010
    ....
  69. doi Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patients
    Valérie Wolff
    Unite Neuro Vasculaire, Hopitaux Universitaires de Strasbourg, France
    Stroke 42:1778-80. 2011
    ..Our objective was to evaluate the relationship between cannabis use and ischemic stroke in a young adult population...
  70. ncbi Assessment of vascular function: flow-mediated constriction complements the information of flow-mediated dilatation
    T Gori
    Department of Medicine 2, University Hospital of Mainz, Mainz, Germany
    Heart 96:141-7. 2010
    ..To determine whether vascular function assessed by low-flow-mediated constriction (L-FMC), a novel non-invasive method, complements the information obtained with "traditional" flow-mediated dilatation (FMD)...
  71. doi Dimethylsulfoxide-soluble smoking particles and nicotine affect vascular contractibility
    Jin Yan Zhang
    Department of Pharmacology, Xi an Jiaotong University College of Medicine, Ministry of Education, Xi an, Shaanxi, China
    Arch Pharm Res 32:1475-81. 2009
    ..The effects of DSP on ET(B) receptor, ET(A) receptor and alpha-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine...
  72. ncbi Pulsed electrical stimulation for control of vasculature: temporary vasoconstriction and permanent thrombosis
    Daniel Palanker
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305 4085, USA
    Bioelectromagnetics 29:100-7. 2008
    ..We describe a non-thermal method of inducing temporary vasoconstriction and permanent thrombosis using short pulse (microseconds) electrical stimulation...
  73. ncbi Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculation
    Barbara Rodenwaldt
    Physiologisches Institut, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Am J Physiol Heart Circ Physiol 292:H2341-8. 2007
    ..This mechanism may support the dilatory potency of NO by preventing the conduction of remote vasoconstrictions into areas with basal or activated NO release...
  74. ncbi Prolactin induces regional vasoconstriction through the beta2-adrenergic and nitric oxide mechanisms
    Claudio Molinari
    Laboratorio di Fisiologia, Dipartimento di Medicina Clinica e Sperimentale, Facolta di Medicina e Chirurgia, Universita del Piemonte Orientale A Avogadro, Via Solaroli 17, I 28100 Novara, Italy
    Endocrinology 148:4080-90. 2007
    ..present study showed that iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction. These effects were brought about by the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated ..
  75. ncbi Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia
    E Kenneth Weir
    University of Minnesota, VA Medical Center 111C, One Veterans Drive, Minneapolis, MN 55417, USA
    Cardiovasc Res 71:630-41. 2006
    ..A better understanding of the pathophysiology of hypoxic pulmonary vasoconstriction and vascular remodeling will enable the design of better treatments for hypoxic and other forms of pulmonary ..
  76. ncbi Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunction
    C A Gunnett
    Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA, USA
    Arterioscler Thromb Vasc Biol 25:1617-22. 2005
    ..Effects of gene transfer of iNOS to carotid arteries were examined in vitro in the absence of systemic inflammation to allow examination of mechanisms by which iNOS impairs contraction and relaxation...
  77. pmc Endothelium-dependent contractions: when a good guy turns bad!
    Paul M Vanhoutte
    Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    J Physiol 586:5295-304. 2008
    ..Endothelium-dependent contractions are exacerbated by ageing, obesity, hypertension and diabetes, and thus are likely to contribute to the endothelial dysfunction observed in older people and in essential hypertensive patients...
  78. ncbi Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor
    Heather A Drummond
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Hypertension 44:643-8. 2004
    ..These data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins...
  79. pmc Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscle
    Brett S Kirby
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523 1582, USA
    J Physiol 586:4305-16. 2008
    ..in Protocol 1, we tested the hypothesis that exogenous ATP can blunt direct postjunctional alpha-adrenergic vasoconstriction in humans...
  80. pmc Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men
    Frank A Dinenno
    Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523 1582, USA
    J Physiol 567:311-21. 2005
    ..we tested the hypothesis that the normal ability of muscle contractions to blunt sympathetic alpha-adrenergic vasoconstriction (functional sympatholysis) is impaired with age in healthy humans...
  81. ncbi Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
    Joseph E Brayden
    Department of Pharmacology, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Clin Exp Pharmacol Physiol 35:1116-20. 2008
    ..to myocyte depolarization, which stimulates Ca2+ entry via voltage-dependent Ca2+ channels (VDCC), leading to vasoconstriction. The TRPV4 channels in arterial myocytes are activated by epoxyeicosatrienoic acids, and activation of the ..
  82. doi Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK
    Hardip Sandhu
    Department of Clinical Experimental Research, Glostrup Research Institute, Ndr Ringvej 69, 2600 Glostrup, Denmark
    Toxicol Appl Pharmacol 249:25-32. 2010
    ..Thus, the MAPK-mediated upregulation of contractile ET(B) receptors in cerebral arteries might be a pharmacological target for the treatment of smoke-associated cerebral vascular disease like stroke...
  83. doi Prostaglandins and radical oxygen species are involved in microvascular effects of hyperoxia
    A Rousseau
    Departments of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden
    J Vasc Res 47:441-50. 2010
    Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood...
  84. pmc Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase
    Zhekang Ying
    Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Am J Physiol Heart Circ Physiol 296:H1540-50. 2009
    ..In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution...
  85. doi Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Cardiol 103:216-20. 2009
    ..These differences are present and can be identified preoperatively by FMD...
  86. ncbi Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteries
    Olga N Lekontseva
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Menopause 17:516-23. 2010
    ..However, the specific impact of aging and/or Ovx on this pathway remains unknown. We hypothesized that aging exacerbates MMP-mediated vasoconstriction in an ovary-deficient state.
  87. ncbi Mechanisms of hydrogen peroxide-induced vasoconstriction in the isolated perfused rat kidney
    J M Moreno
    Departamento de Fisiologia, Facultad de Medicina, Granada, Spain
    J Physiol Pharmacol 61:325-32. 2010
    ..H(2)O(2) induced vasoconstriction in the isolated rat kidney in a concentration-dependent manner...
  88. ncbi Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction
    Farzaneh Ketabchi
    School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Am J Physiol Lung Cell Mol Physiol 297:L977-83. 2009
    ..However, the effects of hypercapnia with or without acidosis on hypoxic pulmonary vasoconstriction (HPV) and oxygen diffusion capacity of the lung are controversial...
  89. pmc S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphate
    William S Szczepaniak
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Lung Cell Mol Physiol 299:L137-45. 2010
    ..S1P-induced vasoconstriction was reduced by 64% by concomitant administration of the Rho-kinase inhibitor Y27632 (10 microM)...
  90. doi Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction
    Beate Fuchs
    Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Aulweg 130, 35392 Giessen, Germany
    Respir Physiol Neurobiol 174:282-91. 2010
    Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism of the lung that matches blood perfusion with alveolar ventilation to optimize gas exchange...
  91. ncbi Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension
    A Armenia
    School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
    Acta Pharmacol Sin 29:564-72. 2008
    ..This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats...
  92. ncbi Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependent
    E A Silveira
    Departamento de Ciencias Fisiologicas, Universidade Federal do Espirito Santo, Vitoria, ES, Brasil
    Braz J Med Biol Res 43:492-9. 2010
    ..Results suggest that acute lead administration affects the endothelium, releasing cyclooxygenase-derived vasoconstrictors and involving reactive oxygen species...
  93. ncbi The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstriction
    P Wangemann
    Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
    Hear Res 115:113-8. 1998
    ..Elevation of the K+ concentration from 3.6 to 150 mM in the superfusate caused a transient vasoconstriction. The amplitude of the K+-induced vasoconstriction depended strongly on the applied intravascular pressure...
  94. ncbi Sirolimus-eluting stents associated with paradoxic coronary vasoconstriction
    Mario Togni
    Swiss Cardiovascular Center Bern, Bern, Switzerland
    J Am Coll Cardiol 46:231-6. 2005
    ..The purpose of the present study was to assess coronary vasomotor response to exercise after sirolimus-eluting stent (SES) implantation...
  95. pmc Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction
    Catherine Vial
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN United Kingdom
    J Biol Chem 280:30705-11. 2005
    ....
  96. doi Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells
    Xiao ru Yang
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA
    Adv Exp Med Biol 661:109-22. 2010
    ..Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary ..
  97. ncbi Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels
    Luis Michea
    Laboratory of Cellular and Molecular Physiology, Faculty of Medicine, University Los Andes, S Carlos Apoquindo 2200, Las Condes, 6782468 Santiago, Chile
    Endocrinology 146:973-80. 2005
    ..Inhibitors of ERK 1/2 phosphorylation (15 microm PD98059) had no effect on aldosterone-mediated vasoconstriction. Inhibition of protein kinase C with 1 microm bi-sindolylmaleimide I and/or inhibition of NHE1 with 100 ..
  98. pmc Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle
    Toshio Kitazawa
    Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
    J Physiol 546:879-89. 2003
    ....
  99. ncbi Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction
    Y M Smulders
    Department of Internal Medicine, Academic Medical Center, Suite F4 222, 9, 1105 AZ, Meibergdreef, The Netherlands
    Cardiovasc Res 48:23-33. 2000
    ..Historic studies indicate that this discrepancy is largely explained by pulmonary vasoconstriction caused by vasoactive mediators, released mainly by activated platelets...
  100. ncbi Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol (1985) 95:2453-61. 2003
    ..It is also accompanied by a fall in arterial Pco2 leading to uncertainty as to whether the cerebral vasoconstriction is totally or only in part caused by arterial hypocapnia...
  101. ncbi Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodeling
    Erik N T P Bakker
    Department of Pharmacology, University of Aarhus, Aarhus, Denmark
    J Vasc Res 41:174-82. 2004
    Remodeling of resistance arteries is a key feature in hypertension. We studied the transition of vasoconstriction to remodeling in isolated rat skeletal muscle arterioles...

Research Grants98

  1. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2001
    ..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
  2. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
  3. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2002
    ..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
  4. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2003
    ..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
  5. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura V Gonzalez Bosc; Fiscal Year: 2010
    ..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
  6. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura Gonzalez Bosc; Fiscal Year: 2009
    ..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
  7. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ..We will examine the ability of each infant to exhibit peripheral vasoconstriction in response to decreased abdominal skin temperature and to keep abdominal temperature higher than peripheral ..
  8. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian M Stewart; Fiscal Year: 2010
    ..One type of "Low flow POTS" (LFP) has increased vasoconstriction associated with increased angiotensin-II (Ang- II), reduced nitric oxide (NO), and increased reactive oxygen ..
  9. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2011
    ..PH is characterized by vascular obstruction and variable presence of vasoconstriction, leading to a sustained increased pulmonary vascular resistance, vascular remodeling, right ventricular (RV) ..
  10. Local Calcium Signaling in Pulmonary Arteries
    JAMES SHAM; Fiscal Year: 2009
    ..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs;and these ..
  11. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2010
    ..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs;and these ..
  12. HORMONAL REGULATION OF BLOOD PRESSURE
    Alberto Nasjletti; Fiscal Year: 1999
    ..of hypertensive rats contribute to increased blood pressure by fostering the expression of PGH2-mediated vasoconstriction and by limiting the activity of vasodilatory mechanisms mediated by PGI2; it also will test the hypothesis ..
  13. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    RAOUF KHALIL; Fiscal Year: 2009
    ..AngII activates angiotensin type 1 receptor (AT1R) to induce vasoconstriction, and angiotensin type 2 receptor (AT2R) to induce the release of vasodilator substances and promote vascular ..
  14. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..AngII activates angiotensin type 1 receptor (AT1R) to induce vasoconstriction, and angiotensin type 2 receptor (AT2R) to induce the release of vasodilator substances and promote vascular ..
  15. NFATc3 in chronic hypoxic pulmonary hypertension
    Laura Gonzalez Bosc; Fiscal Year: 2009
    ..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
  16. Oxidant Stress Mechanisms in Preeclampsia
    Scott W Walsh; Fiscal Year: 2010
    ..Neutrophils infiltrating the vasculature could cause inflammation and vasoconstriction by release of toxic compounds, such as reactive oxygen species (ROS), TNF??and thromboxane...
  17. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    ..The first section will examine clinically relevant amplifiers of arterial vasoconstriction, denudation and cholesterol in the presence of an arterial stenosis...
  18. Age and Control of Human Skin Flow
    W Kenney; Fiscal Year: 2009
    ..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
  19. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2010
    ..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
  20. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 1999
    ..oxygen carrier for clinical use remains elusive, primarily because cell-free hemoglobin induces vasoconstriction and reduced tissue oxygenation...
  21. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2000
    ..oxygen carrier for clinical use remains elusive, primarily because cell-free hemoglobin induces vasoconstriction and reduced tissue oxygenation...
  22. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2002
    ..oxygen carrier for clinical use remains elusive, primarily because cell-free hemoglobin induces vasoconstriction and reduced tissue oxygenation...
  23. OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBIN
    Robert Winslow; Fiscal Year: 2001
    ..oxygen carrier for clinical use remains elusive, primarily because cell-free hemoglobin induces vasoconstriction and reduced tissue oxygenation...
  24. ARACHIDONIC ACID METABOLISM & PERINATAL LUNG CIRCULATION
    Scott Soifer; Fiscal Year: 1990
    In the fetus, pulmonary vascular resistance is high, in part due to active vasoconstriction of the small pulmonary arteries induced by leukotrienes or other vasoconstricting substances...
  25. ACETAMINOPHEN VS IBUPROFEN ON RENAL FUNCTION DURING EXERCISE
    W Kenney; Fiscal Year: 1999
    ..resting conditions, PG inhibition with an NSAID has no appreciable effect on renal function because basal vasoconstriction tone is low. However, during exercise, there is both neural and endocrine stimuli (i.e...
  26. PERIANESTHETIC THERMOREGULATION AND HEAT BALANCE
    Daniel Sessler; Fiscal Year: 1993
    ..plateau in young adults results from constraint of metabolic heat to the core compartment by thermoregulatory vasoconstriction. Unwarmed infants initially become hypothermic during surgery and when sufficiently hypothermic, trigger ..
  27. MECHANISM OF VASCONSTRICTION BY ETHANOL
    ANDREW WERBER; Fiscal Year: 1993
    ..Studies in non-vascular cells and preliminary data by the PI, using blood vessels, suggests that vasoconstriction by ethanol may involve stimulation of protein kinase C...
  28. Perinatal Origins of Chronic Mountain Sickness
    Lorna G Moore; Fiscal Year: 2010
    ..genes contribute to UA blood flow and fetal growth variability and 3) HIF-regulated genes influencing UA vasoconstriction, vasodilation, or growth contribute to the variation in maternal physiologic responses to pregnancy in ..
  29. Perinatal Origins of Chronic Mountain Sickness
    LORNA MOORE; Fiscal Year: 2009
    ..genes contribute to UA blood flow and fetal growth variability and 3) HIF-regulated genes influencing UA vasoconstriction, vasodilation, or growth contribute to the variation in maternal physiologic responses to pregnancy in ..
  30. O2 sensing in the human and rabbit ductus arteriosus
    Stephen L Archer; Fiscal Year: 2010
    ..At birth, functional closure of the DA is initiated within minutes by O2-induced vasoconstriction. Functional closure (vasoconstriction) stops right to left shunting of blood and promotes anatomical closure...
  31. O2 sensing in the human and rabbit ductus arteriosus
    Stephen Archer; Fiscal Year: 2009
    ..At birth, functional closure of the DA is initiated within minutes by O2-induced vasoconstriction. Functional closure (vasoconstriction) stops right to left shunting of blood and promotes anatomical closure...
  32. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..by applicant): We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  33. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2004
    We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  34. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2005
    We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  35. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2007
    ..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
  36. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2006
    ..by applicant): We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
  37. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2009
    ..following fetal bypass and cardiac surgery share all the classic hallmarks of vasopressin mediated vasoconstriction: increased peripheral vasoconstriction, placental vascular resistance, and centralized fetal circulation, ..
  38. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..following fetal bypass and cardiac surgery share all the classic hallmarks of vasopressin mediated vasoconstriction: increased peripheral vasoconstriction, placental vascular resistance, and centralized fetal circulation, ..
  39. REGULATION OF SYMPATHETIC NERVE ACTIVITY DURING EXERCISE
    DOUGLAS SEALS; Fiscal Year: 1990
    The autonomic adjustments to exercise in humans (i.e., tachycardia and vasoconstriction) are thought to be mediated by two primary signals (mechanisms): central command and feedback from group III and IV muscle afferents with mechano- and ..
  40. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2009
    ..following fetal bypass and cardiac surgery share all the classic hallmarks of vasopressin mediated vasoconstriction: increased peripheral vasoconstriction, placental vascular resistance, and centralized fetal circulation, ..
  41. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI PORTER; Fiscal Year: 2009
    ..LT levels and potentially contribute to the progression of PAH, a disorder characterized by pulmonary vasoconstriction and vascular remodeling, by inducing vasoconstriction of the pulmonary vasculature...
  42. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..LT levels and potentially contribute to the progression of PAH, a disorder characterized by pulmonary vasoconstriction and vascular remodeling, by inducing vasoconstriction of the pulmonary vasculature...
  43. Renal Vascular Reactivity in Hypertension
    William J Arendshorst; Fiscal Year: 2011
    ..angiotensin II (Ang II)-induced hypertension (AIH) and that CD38-deficient mice exhibit less pronounced renal vasoconstriction, Na+ retention and AIH than do wild-type (WT) mice...
  44. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy Kanagy; Fiscal Year: 2009
    ..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
  45. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
  46. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy Kanagy; Fiscal Year: 2007
    ..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
  47. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    Sandra L Pfister; Fiscal Year: 2010
    ..b>Vasoconstriction, vascular remodeling and thrombosis all contribute to the increased vascular resistance...
  48. TBC22351NA IN PATIENTS WITH PULMONARY VASCULAR DISEASE
    Robyn Barst; Fiscal Year: 2000
    ..Endothelin causes pulmonary vasoconstriction, e.g. closes the blood vessels in the lungs, thereby decreasing the blood pressure in the lungs...
  49. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1991
    ..It is believed that cocaine may cause cerebral vasoconstriction leading to intracranial hemorrhage or cerebral infarction...
  50. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..It is believed that cocaine may cause cerebral vasoconstriction leading to intracranial hemorrhage or cerebral infarction...
  51. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2010
    ..Although the role of ETAR in mediating vasoconstriction and hypertension (HTN) has been studied extensively, the role of ETBR in the regulation of vascular function ..
  52. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    PAUL FADEL; Fiscal Year: 2009
    ..Furthermore, since augmented sympathetically-mediated vasoconstriction would not only cause an elevation in BP but may also limit blood flow to active muscle, aim 2 is designed to ..
  53. Aging, Sex, and Neural Cardiovascular Control During Dynamic Exercise
    PAUL FADEL; Fiscal Year: 2009
    ..Furthermore, since augmented sympathetically-mediated vasoconstriction would not only cause an elevation in BP but may also limit blood flow to active muscle, aim 2 is designed to ..
  54. Tyrosine Kinases in Renal Vasoconstrictor Signaling
    PAMELA CARMINES; Fiscal Year: 2007
    ..The primary Na+ retaining hormone, angiotensin II (AngII) elicits preglomerular (and postglomerular) vasoconstriction via engagement of AT1 receptors (AT1R), which provoke G protein-mediated phospholipase C (PLC) activation and ..
  55. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2009
    ..of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization...
  56. TRP Channel-Dependent Regulation of Arterial Tone
    Scott Earley; Fiscal Year: 2009
    ..of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization...
  57. Tyrosine Kinases in Renal Vasoconstrictor Signaling
    PAMELA CARMINES; Fiscal Year: 2006
    ..The primary Na+ retaining hormone, angiotensin II (AngII) elicits preglomerular (and postglomerular) vasoconstriction via engagement of AT1 receptors (AT1R), which provoke G protein-mediated phospholipase C (PLC) activation and ..
  58. ENDOTHELIN AND NITRIC OXIDE IN THE PLACENTAL VASCULATURE
    Leslie Myatt; Fiscal Year: 1992
    ..There is also evidence that these agents may participate in or mediate hypoxia-induced vasoconstriction in some vascular beds...
  59. PULMONARY MICROCIRCULATORY HEMODYNAMICS
    WILTZ WAGNER; Fiscal Year: 1999
    ..largely passive circuit which, nevertheless, is capable of balancing perfusion to ventilation by hypoxic vasoconstriction. With regard to the hemodynamics of the actual gas exchange vessels, however, there are many unexplored areas ..
  60. Mechanisms of MDMA-induced hyperthermia
    Edward Mills; Fiscal Year: 2009
    ..dramatic increase in "non-shivering" metabolic thermogenesis in the setting of heat conservation (peripheral vasoconstriction)...
  61. PRENATAL COCAINE--ACUTE AND DELAYED FUNCTIONAL TOXICITY
    SHELDON SPARBER; Fiscal Year: 1999
    b>Vasoconstriction, as well as other actions of cocaine in the developing fetus, may be responsible for some of the reported congenital effects in the clinical and animal literature...
  62. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
  63. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian Stewart; Fiscal Year: 2006
    ..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
  64. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian Stewart; Fiscal Year: 2005
    ..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
  65. Local Vasoconstriction in Postural Tachycardia Syndrome
    Julian Stewart; Fiscal Year: 2007
    ..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
  66. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    SANDRA PFISTER; Fiscal Year: 2009
    ..b>Vasoconstriction, vascular remodeling and thrombosis all contribute to the increased vascular resistance...
  67. Fibrinogen-induced vasoconstriction during hypertension
    David Lominadze; Fiscal Year: 2007
    ..We reported that binding of Fg to the arterial wall causes vasoconstriction, which is mediated by intercellular adhesion molecule-1 (ICAM-1)...
  68. Fibrinogen-induced vasoconstriction during hypertension
    David Lominadze; Fiscal Year: 2009
    ..We reported that binding of Fg to the arterial wall causes vasoconstriction, which is mediated by intercellular adhesion molecule-1 (ICAM-1)...
  69. INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROL
    STEVEN SEGAL; Fiscal Year: 1999
    ..flow; conducted (but not localized) vasodilation increases microvascular perfusion and attenuates sympathetic vasoconstriction. Nevertheless, the signal(s) which underlie conduction are unknown...
  70. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 1993
    ..amounts of heme proteins discharged during rhabdomyolysis, the kidney exhibits prompt and prominent renal vasoconstriction, tubular necrosis and cast nephropathy...
  71. PERIANETHETIC TREMOR AND THERMOREGULATION
    Daniel Sessler; Fiscal Year: 1990
    ..anesthetic concentrations in the brain decrease rapidly, and normal compensation for hypothermia triggers vasoconstriction, shivering, and nonshivering thermogenesis...
  72. ANTIOXIDANT MODULATION OF FREE RADICAL GENERATION IN CIRRHOSIS
    EMMA MEAGHER; Fiscal Year: 1999
    ..In addition, I explored the theory that vasoconstriction mediated by thromboxane A(2) results in exacerbation of hepatic injury and that while the enzymatically ..
  73. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl A Nath; Fiscal Year: 2010
    ..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
  74. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2009
    ..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
  75. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 2000
    ..goal of this project is further understanding of the mechanisms underlying the exaggerated reflex renal vasoconstriction in humans with heart failure during exercise...
  76. SURGICAL CONTROL OF POST-TRAUMATIC LUNG INJURY
    David Fullerton; Fiscal Year: 1993
    ..Such abnormalities may help explain the avid pulmonary vasoconstriction of acute lung injury. Physiologically, the principle pulmonary vasoconstrictor is hypoxia...
  77. RENAL INJURY AND ADAPTATION TO HEME PROTEINS
    Karl Nath; Fiscal Year: 2009
    ..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
  78. RENAL BLOOD FLOW DURING EXERCISE IN HEART FAILURE
    Holly Middlekauff; Fiscal Year: 1999
    ..goal of this project is further understanding of the mechanisms underlying the exaggerated reflex renal vasoconstriction in humans with heart failure during exercise...
  79. Redistribution of pulmonary perfusion during bronchoconstriction in asthma
    Robert Harris; Fiscal Year: 2009
    ..are 1) The redistribution of perfusion away from ventilation defects is primarily caused by hypoxic pulmonary vasoconstriction and is not solely an artifact of methacholine-induced bronchoconstriction and 2) For a given degree of ..
  80. Redistribution of pulmonary perfusion during bronchoconstriction in asthma
    ROBERT SCOTT HARRIS; Fiscal Year: 2010
    ..are 1) The redistribution of perfusion away from ventilation defects is primarily caused by hypoxic pulmonary vasoconstriction and is not solely an artifact of methacholine-induced bronchoconstriction and 2) For a given degree of ..
  81. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2004
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  82. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2005
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  83. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2005
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  84. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2006
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  85. Arterial Baroreflex Control of Blood Pressure (Exercise)
    Peter Raven; Fiscal Year: 2003
    ..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
  86. ENDOTHELIUM-DERIVED VASODILATORS IN PREGNANCY
    RONALD MAGNESS; Fiscal Year: 1993
    ..cardiovascular adaptations in pregnancy include generalized vasodilation and reduced uterine and systemic vasoconstriction in response to infused angiotensin II (ANG II) and alpha-agonists...
  87. Vascular RhoA/Rho-kinase Signaling in Angiotensin II-induced Hypertension
    R Webb; Fiscal Year: 2007
    Increased peripheral resistance in hypertension may be caused by a vasoconstriction resulting from enhanced transduction of signals promoting contractile protein activation within the vascular myocyte...
  88. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2001
    ..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...
  89. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2002
    ..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...
  90. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2000
    ..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...