Genomes and Genes
Summary: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Publications347 found, 100 shown here
- Narrative review: reversible cerebral vasoconstriction syndromesLeonard H Calabrese
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Ann Intern Med 146:34-44. 2007Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without ..
- Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxideY J Gao
Department of Anesthesia, Smooth Muscle Research Program, McMaster University, Hamilton, Ontario, Canada
Br J Pharmacol 151:323-31. 2007..Perivascular adipose tissue (PVAT) attenuates vascular contraction, but the mechanisms remain largely unknown. The possible involvement of endothelium (E) and hydrogen peroxide (H2O2) was investigated...
- Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteriesSalvatore Salomone
Stroke and Neurovascular Laboratory Regulation, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Pharmacol Res 62:465-74. 2010..Basilar arteries from SPK1(-/-) mice exhibited weaker vasoconstriction to both KCl and agonists (S1P and the prostanoid U46619) when compared to either wild type (WT) or SPK2(-/-)...
- Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in ratsMasahiko Oka
Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
Circ Res 100:923-9. 2007Vascular remodeling, rather than vasoconstriction, is believed to account for high vascular resistance in severe pulmonary arterial hypertension (PAH)...
- Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndromeU Deniz Dincer
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, USA
Microcirculation 13:587-95. 2006This study tested whether alpha -adrenoceptor-mediated coronary vasoconstriction is augmented in the metabolic syndrome and is accompanied by the alteration of specific alpha(1)- and alpha(2)-coronary adrenoceptors.
- Glial cells dilate and constrict blood vessels: a mechanism of neurovascular couplingMonica R Metea
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 26:2862-70. 2006..These results indicate that glial cells contribute to neurovascular coupling and suggest that regulation of blood flow may involve both vasodilating and vasoconstricting components...
- A novel potent vasoconstrictor peptide produced by vascular endothelial cellsM Yanagisawa
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Nature 332:411-5. 1988..Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system...
- Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchangeNorbert Weissmann
University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
Proc Natl Acad Sci U S A 103:19093-8. 2006Regional alveolar hypoxia causes local vasoconstriction in the lung, shifting blood flow from hypoxic to normoxic areas, thereby maintaining gas exchange. This mechanism is known as hypoxic pulmonary vasoconstriction (HPV)...
- Cerebral vasospasm: looking beyond vasoconstrictionJacob Hansen Schwartz
Department of Neurosurgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK 2100, Denmark
Trends Pharmacol Sci 28:252-6. 2007..recently been challenged by the failure of the drug clazosentan to improve patient outcome, despite reversing vasoconstriction. In this article, we discuss the opinion that factors other than vasoconstriction are important in the ..
- Endothelial dysfunction and vascular diseaseP M Vanhoutte
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
Acta Physiol (Oxf) 196:193-222. 2009..g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients...
- Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slicesRenate Paddenberg
University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
Respir Res 7:93. 2006Acute alveolar hypoxia causes pulmonary vasoconstriction (HPV) which serves to match lung perfusion to ventilation. The underlying mechanisms are not fully resolved yet...
- Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholdsP Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesthesiology 87:835-41. 1997Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature...
- Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literatureDexter L Lee
Department of Physiology, Medical College of Georgia, Augusta 30912 3000, USA
Hypertension 44:796-9. 2004..This brief review will highlight recent studies demonstrating a role for the RhoA/Rho-kinase signaling pathway in the increased vasoconstriction characteristic of hypertension.
- The importance of endothelin-1 for vascular dysfunction in cardiovascular diseaseFelix Bohm
Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden
Cardiovasc Res 76:8-18. 2007..Based on these observations and the biological effects induced by ET-1, including profound vasoconstriction, pro-inflammatory actions, mitogenic and proliferative effects, stimulation of free radical formation and ..
- Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhageSaema Ansar
Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, 221 84 Lund, Sweden
Am J Physiol Heart Circ Physiol 293:H3750-8. 2007..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage...
- The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flowIvan B Lobov
Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 6707, USA
Blood 117:6728-37. 2011..Modulation of VEGF-A and Dll4/Notch signaling produced distinct changes in blood vessel morphology and gene expression, indicating that these pathways can have largely independent functions in vascular remodeling...
- Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular functionTommaso Gori
Department of Internal, Cardiovascular and Geriatric Medicine, University of Siena, Siena, Italy
J Am Coll Cardiol 51:1953-8. 2008..We describe and validate a novel noninvasive method that complements the data from "traditional" flow-mediated dilation (FMD) studies...
- High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive ratsDong You
INSERM Unit 541, AP HP Hôpital Lariboisière, Paris, France
Circulation 111:1006-11. 2005....
- A role for Rho kinase in vascular contraction evoked by sodium fluorideSu Bun Jeon
Department of Pharmacology, Kyungpook National University School of Medicine, Daegu 700 422, Republic of Korea
Biochem Biophys Res Commun 343:27-33. 2006..These results indicate that activation of Rho-kinase and the subsequent phosphorylation of MYPT1(Thr696) play important roles in NaF-induced contraction of rat aortae...
- Postural hypocapnic hyperventilation is associated with enhanced peripheral vasoconstriction in postural tachycardia syndrome with normal supine blood flowJulian M Stewart
Department of Pediatrics, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
Am J Physiol Heart Circ Physiol 291:H904-13. 2006..and hyperemia occurred in both POTS groups compared with controls, marked enhancement in peripheral vasoconstriction occurred only in POTS(HC) and was related to thoracic blood flow...
- Hypoxic pulmonary vasoconstrictionJ T Sylvester
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
Physiol Rev 92:367-520. 2012It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung...
- Chronic HgCl(2) treatment increases vasoconstriction induced by electrical field stimulation: role of adrenergic and nitrergic innervationJavier Blanco-Rivero
Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
Clin Sci (Lond) 121:331-41. 2011..These findings offer further evidence that mercury, even at low concentrations, is an environmental risk factor for cardiovascular disease...
- Prolonged morphine exposure in utero causes fetal and placental vasoconstriction: a case reportLaura R Collins
Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
J Matern Fetal Neonatal Med 17:417-21. 2005b>Vasoconstriction was observed in the fetal middle cerebral and umbilical arteries by Doppler assessment at 27 weeks gestation in a patient requiring continuous morphine infusion for pain control. Fetal heart tracings were also concerning...
- Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arteriolesAnthony J Donato
Department of Health and Kinisiology, Texas A and M University, College Station, TX 77843, USA
J Physiol 579:115-25. 2007..Vasodilator responses to isoproterenol and forskolin were also determined. Results: Noradrenaline-mediated vasoconstriction was increased in SOL arterioles with ageing, and exercise training in old rats attenuated alpha-adrenergic ..
- Physiological regulation of penile arteries and veinsD Prieto
Departamento de Fisiologia, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
Int J Impot Res 20:17-29. 2008..Sympathetic nerves maintain flaccidity and tonically released noradrenaline induces vasoconstriction of both arteries and veins through alpha(1)- and alpha(2)-postsynaptic receptors and downregulates its own ..
- Levobupivacaine-induced contraction of isolated rat aorta is calcium dependentJi Seok Baik
Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea
Can J Physiol Pharmacol 89:467-76. 2011Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels...
- Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activationMichael W Brands
Department of Physiology, Medical College of Georgia, Augusta, GA 30912 3000, USA
Hypertension 56:879-84. 2010..These data suggest that IL-6-dependent activation of the renal janus kinase 2/signal transducer and activator of transcription 3 pathway plays a role in Ang II hypertension but not by mediating the effect of Ang II to decrease total RBF...
- Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen speciesLorena B Furieri
Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid, Instituto de Investigación Hospital Universitario La Paz IdiPAZ, Madrid, Spain
Br J Pharmacol 162:1819-31. 2011..Exposure to mercury is known to increase cardiovascular risk but the underlying mechanisms are not well explored. We analysed whether chronic exposure to low mercury doses affects endothelial modulation of the coronary circulation...
- Vasoconstrictor prostanoidsMichel Feletou
Institut Recherches Servier, Suresnes, France
Pflugers Arch 459:941-50. 2010..TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation...
- Calcium transients in astrocyte endfeet cause cerebrovascular constrictionsSean J Mulligan
Brain Research Centre, Department of Psychiatry, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
Nature 431:195-9. 2004..b>Vasoconstriction by astrocytes is a previously unknown mechanism for the regulation of CBF.
- Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclinPascale Gluais
Institut de Recherches Servier, 92150 Suresnes, France
Br J Pharmacol 146:834-45. 2005..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
- Cellular signaling and potential new treatment targets in diabetic retinopathyZia A Khan
Department of Pathology, University of Western Ontario, London, Ontario, Canada
Exp Diabetes Res 2007:31867. 2007..Understanding of such mechanistic pathways will help to develop future adjuvant therapies for diabetic retinopathy...
- Transcranial color doppler study for reversible cerebral vasoconstriction syndromesShih Pin Chen
Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
Ann Neurol 63:751-7. 2008Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by thunderclap headaches and reversible cerebral vasoconstrictions. No systematic studies on cerebral hemodynamics have been published.
- Tumor necrosis factor-alpha induces renal vasoconstriction as well as natriuresis in miceMohd Shahid
Dept of Physiology, SL 39, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Renal Physiol 295:F1836-44. 2008..1 microg.g(-1).min(-1); n = 6) resulted in further enhancement in vasoconstriction while natriuresis remained unaffected in response to TNF-alpha...
- SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstrictionSung Sen Yang
Division of Nephrology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
J Am Soc Nephrol 21:1868-77. 2010..In summary, SPAK-null mice have defects of NCC in the kidneys and NKCC1 in the blood vessels, leading to hypotension through renal salt wasting and vasodilation. SPAK may be a promising target for antihypertensive therapy...
- Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restrictedJ S Morton
Department of Obstetrics, 232 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada
Am J Physiol Regul Integr Comp Physiol 298:R930-8. 2010..A change in the mechanisms of vasodilation occurring at an earlier age in IUGR offspring may predispose them to adult cardiovascular diseases...
- Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptorsMichel Feletou
Department of Angiology, Institut de Recherches Servier, Suresnes, France
Br J Pharmacol 156:563-74. 2009..Nevertheless, because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium-dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes...
- Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertensionStephanie W Watts
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824 1317, USA
Hypertension 39:825-9. 2002..Although similarities were observed for large and small arteries, differences under the condition of DOCA-salt hypertension exist that may determine serotonergic compounds effective in lowering blood pressure...
- Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degenerationDomniki N Papadopoulou
Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
Ophthalmology 116:1755-61. 2009..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
- Vascular plasticity in cerebrovascular disordersLars I H Edvinsson
Department of Clinical Experimental Research, Copenhagen University, Glostrup Hospital Research Park, Copenhagen, Denmark
J Cereb Blood Flow Metab 31:1554-71. 2011..Together, those findings provide new perspectives on the pathophysiology of ischemic stroke and point toward a novel way of reducing vasoconstriction, neuronal cell death, and thus neurologic deficits after stroke.
- Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy menFrank A Dinenno
Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Circulation 106:1349-54. 2002..We tested the hypothesis that this is due to a reduction in postjunctional alpha-adrenergic responsiveness to endogenous norepinephrine (NE) release and determined whether this was specific to alpha1- or alpha2-adrenergic receptors...
- Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal dietChristopher Torrens
Liggins Institute, Faculty of Medical and Health Science, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand
Br J Nutr 101:27-33. 2009..b>Vasoconstriction to endothelin was significantly enhanced in all groups compared with controls (-log effective concentration ..
- Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive ratTeddy Bagnost
Laboratory of Physiology, Pharmacology, Experimental Preventive Nutrition, EA 3921, Cellular and Metabolic Optimization, Faculty of Medicine and Pharmacy, Besancon University Hospital, Besancon, France
J Hypertens 26:1110-8. 2008..The present study investigated the effects of in-vivo arginase inhibition on blood pressure and vascular function in adult spontaneously hypertensive rats...
- ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in ratSaema A S Beg
Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University Hospital, Lund, Sweden
J Cereb Blood Flow Metab 26:846-56. 2006..Cerebral ischemia after SAH involves vasoconstriction and subsequent reduction in the CBF...
- Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty ratsXiao Lu
Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
Cardiovasc Diabetol 9:19. 2010..The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling...
- Capacitative Ca(2+) entry in agonist-induced pulmonary vasoconstrictionS S McDaniel
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California School of Medicine, San Diego, California 92103, USA
Am J Physiol Lung Cell Mol Physiol 280:L870-80. 2001..These results suggest that CCE, potentially through transient receptor potential-encoded Ca(2+) channels, plays an important role in agonist-mediated PA contraction...
- Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) geneW Steudel
Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Circ Res 81:34-41. 1997..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
- Ginger lowers blood pressure through blockade of voltage-dependent calcium channelsMuhammad Nabeel Ghayur
Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan
J Cardiovasc Pharmacol 45:74-80. 2005..These data indicate that the blood pressure-lowering effect of ginger is mediated through blockade of voltage-dependent calcium channels...
- Long-term effects of maternal diabetes on vascular reactivity and renal function in rat male offspringSilvia O Rocha
Department of Physiology, Federal University of Sao Paulo, Brazil
Pediatr Res 58:1274-9. 2005....
- Periadventitial fat releases a vascular relaxing factorMatthias Löhn
HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
FASEB J 16:1057-63. 2002..We suggest that perivascular adventitial adipose tissue releases a transferable adventitium-derived relaxing factor that acts by tyrosine kinase-dependent activation of K+ channels in vascular smooth muscle cells...
- Role of thromboxane A₂-activated nonselective cation channels in hypoxic pulmonary vasoconstriction of ratHae Young Yoo
Department of Physiology, Seoul National University College of Medicine Seoul, Korea
Am J Physiol Cell Physiol 302:C307-17. 2012Hypoxia-induced pulmonary vasoconstriction (HPV) is critical for matching of ventilation/perfusion in lungs...
- Effect of ischemia duration and nitric oxide on coronary vasoconstriction after ischemia-reperfusionAngel Luis García-Villalón
Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, Madrid 28029, Spain
Eur J Pharmacol 509:165-70. 2005The effects of the duration of ischemia on coronary vasoconstriction after ischemia-reperfusion were analysed in rat hearts...
- NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungsN Weissmann
Department of Internal Medicine, Justus Liebig University Giessen, Klinikstrasse 36, 35392 Giessen, Germany
Am J Physiol Lung Cell Mol Physiol 280:L638-45. 2001Hypoxic pulmonary vasoconstriction (HPV) matches lung perfusion with ventilation but may also result in chronic pulmonary hypertension...
- Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytesMaria Alícia Carrillo-Sepúlveda
Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Professor Lineu Prestes 2415, Sao Paulo 05508 900, Brazil
Cardiovasc Res 85:560-70. 2010..We hypothesize that TH-induced rapid vascular relaxation is mediated by VSMC-derived nitric oxide (NO) production and is associated with the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway...
- Iodinated contrast induced renal vasoconstriction is due in part to the downregulation of renal cortical and medullary nitric oxide synthesisStuart I Myers
McGuire Research Institute McGuire Veterans Administration Medical Center and Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA
J Vasc Surg 44:383-91. 2006....
- Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathwayHilda Ahnstedt
Department of Clinical Sciences, Lund University, Sweden
BMC Neurosci 12:5. 2011..Contractile properties were evaluated in a myograph and protein expression of the individual receptors and activated phosphorylated B-Raf (p-B-Raf) was evaluated immunohistochemically...
- Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthaseChi Yung Yuen
Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Cardiovasc Res 90:122-9. 2011....
- NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channelXiao Yu Tian
Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
Pharmacol Res 65:239-46. 2012....
- Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transectionJames A Brock
Prince of Wales Medical Research Institute, University of New South Wales, Randwick, NSW 2031, Australia
Am J Physiol Heart Circ Physiol 290:H398-405. 2006..The findings provide further support for potentiated neurovascular responses contributing to the genesis of autonomic dysreflexia...
- Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failureH R Middlekauff
Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
J Appl Physiol (1985) 90:1714-9. 2001In heart failure (HF) patients, reflex renal vasoconstriction during exercise is exaggerated. We hypothesized that muscle mechanoreceptor control of renal vasoconstriction is exaggerated in HF...
- Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodellingDorota Dajnowiec
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Clin Sci (Lond) 113:15-23. 2007..Current efforts to define these signals and their targets may provide new directions for therapeutic interventions to treat important vascular disorders...
- Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humansJeremy P Langrish
Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
Hypertension 54:910-5. 2009..05 for all). ET-1 infusion increased plasma ET-1 concentrations by 58% (P<0.01) but caused vasoconstriction only after diesel exhaust exposure (-17% versus 2% after air; P<0.001)...
- Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteriesG A Wiggers
Departamento de Farmacologia, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain
Am J Physiol Heart Circ Physiol 295:H1033-H1043. 2008..59 ng/ml. Mercury treatment: 1) did not affect systolic blood pressure; 2) increased phenylephrine-induced vasoconstriction; 3) reduced acetylcholine-induced vasodilatation; and 4) reduced in aorta and abolished in MRA the increased ..
- Segmental cerebral vasoconstriction: successful treatment of secondary cerebral ischaemia with intravenous prostacyclinPer Olof Grände
Department of Anaesthesiology and Intensive Care, Lund University and Lund University Hospital, Lund, Sweden
Cephalalgia 30:890-5. 2010..brain ischaemia and oedema within the left cerebral hemisphere with strict ipsilateral segmental arterial vasoconstriction. Despite extensive medical care, including steroids, the patient deteriorated rapidly...
- Pulmonary vascular involvement in COPDVictor I Peinado
Department of Pulmonary Medicine, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
Chest 134:808-14. 2008..The safety and efficacy of endothelium-targeted therapy in COPD-associated pulmonary hypertension warrants further investigation in randomized clinical trials...
- Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodelingPeter Pokreisz
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute of Biotechnology, University of Leuven, Belgium
Hypertension 47:762-70. 2006..the response (by 39%), indicating that CYP epoxygenase-derived epoxyeicosatrienoic acids elicit pulmonary vasoconstriction. Aerosol gene transfer of recombinant adenovirus containing the human CYP2C9 significantly elevated mean ..
- Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstrictionMatthias R Meyer
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Hypertension 59:507-12. 2012..that nonselective estrogen receptor agonists such as endogenous estrogens inhibit endothelium-dependent vasoconstriction; however, the role of estrogen receptors in this response has not yet been clarified...
- Phenotypic modulation of cultured vascular smooth muscle cells: a functional analysis focusing on MLC and ERK1/2 phosphorylationM A Carrillo-Sepúlveda
Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Cidade Universitaria, Sao Paulo, Brazil
Mol Cell Biochem 341:279-89. 2010....
- Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patientsValérie Wolff
Unite Neuro Vasculaire, Hopitaux Universitaires de Strasbourg, France
Stroke 42:1778-80. 2011..Our objective was to evaluate the relationship between cannabis use and ischemic stroke in a young adult population...
- Assessment of vascular function: flow-mediated constriction complements the information of flow-mediated dilatationT Gori
Department of Medicine 2, University Hospital of Mainz, Mainz, Germany
Heart 96:141-7. 2010..To determine whether vascular function assessed by low-flow-mediated constriction (L-FMC), a novel non-invasive method, complements the information obtained with "traditional" flow-mediated dilatation (FMD). Design and..
- Dimethylsulfoxide-soluble smoking particles and nicotine affect vascular contractibilityJin Yan Zhang
Department of Pharmacology, Xi an Jiaotong University College of Medicine, Ministry of Education, Xi an, Shaanxi, China
Arch Pharm Res 32:1475-81. 2009..The effects of DSP on ET(B) receptor, ET(A) receptor and alpha-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine...
- Pulsed electrical stimulation for control of vasculature: temporary vasoconstriction and permanent thrombosisDaniel Palanker
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305 4085, USA
Bioelectromagnetics 29:100-7. 2008..We describe a non-thermal method of inducing temporary vasoconstriction and permanent thrombosis using short pulse (microseconds) electrical stimulation...
- Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculationBarbara Rodenwaldt
Physiologisches Institut, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Am J Physiol Heart Circ Physiol 292:H2341-8. 2007..This mechanism may support the dilatory potency of NO by preventing the conduction of remote vasoconstrictions into areas with basal or activated NO release...
- Prolactin induces regional vasoconstriction through the beta2-adrenergic and nitric oxide mechanismsClaudio Molinari
Laboratorio di Fisiologia, Dipartimento di Medicina Clinica e Sperimentale, Facolta di Medicina e Chirurgia, Universita del Piemonte Orientale A Avogadro, Via Solaroli 17, I 28100 Novara, Italy
Endocrinology 148:4080-90. 2007..present study showed that iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction. These effects were brought about by the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated ..
- Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxiaE Kenneth Weir
University of Minnesota, VA Medical Center 111C, One Veterans Drive, Minneapolis, MN 55417, USA
Cardiovasc Res 71:630-41. 2006..A better understanding of the pathophysiology of hypoxic pulmonary vasoconstriction and vascular remodeling will enable the design of better treatments for hypoxic and other forms of pulmonary ..
- Mechanisms of inducible nitric oxide synthase-mediated vascular dysfunctionC A Gunnett
Department of Internal Medicine, University of Iowa Carver College of Medicine, VA Medical Center, Iowa City, IA, USA
Arterioscler Thromb Vasc Biol 25:1617-22. 2005..Effects of gene transfer of iNOS to carotid arteries were examined in vitro in the absence of systemic inflammation to allow examination of mechanisms by which iNOS impairs contraction and relaxation...
- Endothelium-dependent contractions: when a good guy turns bad!Paul M Vanhoutte
Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
J Physiol 586:5295-304. 2008..Endothelium-dependent contractions are exacerbated by ageing, obesity, hypertension and diabetes, and thus are likely to contribute to the endothelial dysfunction observed in older people and in essential hypertensive patients...
- Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensorHeather A Drummond
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA
Hypertension 44:643-8. 2004..These data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins...
- Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscleBrett S Kirby
Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523 1582, USA
J Physiol 586:4305-16. 2008..in Protocol 1, we tested the hypothesis that exogenous ATP can blunt direct postjunctional alpha-adrenergic vasoconstriction in humans...
- Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing menFrank A Dinenno
Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523 1582, USA
J Physiol 567:311-21. 2005..we tested the hypothesis that the normal ability of muscle contractions to blunt sympathetic alpha-adrenergic vasoconstriction (functional sympatholysis) is impaired with age in healthy humans...
- Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flowJoseph E Brayden
Department of Pharmacology, The University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
Clin Exp Pharmacol Physiol 35:1116-20. 2008..to myocyte depolarization, which stimulates Ca2+ entry via voltage-dependent Ca2+ channels (VDCC), leading to vasoconstriction. The TRPV4 channels in arterial myocytes are activated by epoxyeicosatrienoic acids, and activation of the ..
- Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPKHardip Sandhu
Department of Clinical Experimental Research, Glostrup Research Institute, Ndr Ringvej 69, 2600 Glostrup, Denmark
Toxicol Appl Pharmacol 249:25-32. 2010..Thus, the MAPK-mediated upregulation of contractile ET(B) receptors in cerebral arteries might be a pharmacological target for the treatment of smoke-associated cerebral vascular disease like stroke...
- Prostaglandins and radical oxygen species are involved in microvascular effects of hyperoxiaA Rousseau
Departments of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden
J Vasc Res 47:441-50. 2010Hyperoxia causes vasoconstriction in most tissues, by mechanisms that are not fully understood...
- Air pollution and cardiac remodeling: a role for RhoA/Rho-kinaseZhekang Ying
Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
Am J Physiol Heart Circ Physiol 296:H1540-50. 2009..In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution...
- Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass graftingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Am J Cardiol 103:216-20. 2009..These differences are present and can be identified preoperatively by FMD...
- Ovariectomy in aged versus young rats augments matrix metalloproteinase-mediated vasoconstriction in mesenteric arteriesOlga N Lekontseva
Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
Menopause 17:516-23. 2010..However, the specific impact of aging and/or Ovx on this pathway remains unknown. We hypothesized that aging exacerbates MMP-mediated vasoconstriction in an ovary-deficient state.
- Mechanisms of hydrogen peroxide-induced vasoconstriction in the isolated perfused rat kidneyJ M Moreno
Departamento de Fisiologia, Facultad de Medicina, Granada, Spain
J Physiol Pharmacol 61:325-32. 2010..H(2)O(2) induced vasoconstriction in the isolated rat kidney in a concentration-dependent manner...
- Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstrictionFarzaneh Ketabchi
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Am J Physiol Lung Cell Mol Physiol 297:L977-83. 2009..However, the effects of hypercapnia with or without acidosis on hypoxic pulmonary vasoconstriction (HPV) and oxygen diffusion capacity of the lung are controversial...
- S1P2 receptor-dependent Rho-kinase activation mediates vasoconstriction in the murine pulmonary circulation induced by sphingosine 1-phosphateWilliam S Szczepaniak
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Physiol Lung Cell Mol Physiol 299:L137-45. 2010..S1P-induced vasoconstriction was reduced by 64% by concomitant administration of the Rho-kinase inhibitor Y27632 (10 microM)...
- Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstrictionBeate Fuchs
Excellence Cluster Cardio Pulmonary System, University of Giessen Lung Center, Department of Internal Medicine II, Justus Liebig University Giessen, Aulweg 130, 35392 Giessen, Germany
Respir Physiol Neurobiol 174:282-91. 2010Hypoxic pulmonary vasoconstriction (HPV) is an essential physiological mechanism of the lung that matches blood perfusion with alveolar ventilation to optimize gas exchange...
- Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertensionA Armenia
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Acta Pharmacol Sin 29:564-72. 2008..This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats...
- Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependentE A Silveira
Departamento de Ciencias Fisiologicas, Universidade Federal do Espirito Santo, Vitoria, ES, Brasil
Braz J Med Biol Res 43:492-9. 2010..Results suggest that acute lead administration affects the endothelium, releasing cyclooxygenase-derived vasoconstrictors and involving reactive oxygen species...
- The isolated in vitro perfused spiral modiolar artery: pressure dependence of vasoconstrictionP Wangemann
Cell Physiology Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA
Hear Res 115:113-8. 1998..Elevation of the K+ concentration from 3.6 to 150 mM in the superfusate caused a transient vasoconstriction. The amplitude of the K+-induced vasoconstriction depended strongly on the applied intravascular pressure...
- Sirolimus-eluting stents associated with paradoxic coronary vasoconstrictionMario Togni
Swiss Cardiovascular Center Bern, Bern, Switzerland
J Am Coll Cardiol 46:231-6. 2005..The purpose of the present study was to assess coronary vasomotor response to exercise after sirolimus-eluting stent (SES) implantation...
- Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstrictionCatherine Vial
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN United Kingdom
J Biol Chem 280:30705-11. 2005....
- Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cellsXiao ru Yang
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, 21224, USA
Adv Exp Med Biol 661:109-22. 2010..Increasing evidence suggests that these channels play crucial roles in agonist-induced pulmonary vasoconstriction, hypoxic pulmonary vasoconstriction, smooth muscle cell proliferation, vascular remodeling, and pulmonary ..
- Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vesselsLuis Michea
Laboratory of Cellular and Molecular Physiology, Faculty of Medicine, University Los Andes, S Carlos Apoquindo 2200, Las Condes, 6782468 Santiago, Chile
Endocrinology 146:973-80. 2005..Inhibitors of ERK 1/2 phosphorylation (15 microm PD98059) had no effect on aldosterone-mediated vasoconstriction. Inhibition of protein kinase C with 1 microm bi-sindolylmaleimide I and/or inhibition of NHE1 with 100 ..
- Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscleToshio Kitazawa
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA
J Physiol 546:879-89. 2003....
- Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstrictionY M Smulders
Department of Internal Medicine, Academic Medical Center, Suite F4 222, 9, 1105 AZ, Meibergdreef, The Netherlands
Cardiovasc Res 48:23-33. 2000..Historic studies indicate that this discrepancy is largely explained by pulmonary vasoconstriction caused by vasoactive mediators, released mainly by activated platelets...
- Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATAThomas F Floyd
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Appl Physiol (1985) 95:2453-61. 2003..It is also accompanied by a fall in arterial Pco2 leading to uncertainty as to whether the cerebral vasoconstriction is totally or only in part caused by arterial hypocapnia...
- Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodelingErik N T P Bakker
Department of Pharmacology, University of Aarhus, Aarhus, Denmark
J Vasc Res 41:174-82. 2004Remodeling of resistance arteries is a key feature in hypertension. We studied the transition of vasoconstriction to remodeling in isolated rat skeletal muscle arterioles...
- Circulatory Dysfunction in Chronic Fatigue SyndromeJulian Stewart; Fiscal Year: 2004..Preliminary data suggest the novel concept that defective vasoconstriction produces POTS in CFS with cardiac autonomic changes as a secondary response...
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura V Gonzalez Bosc; Fiscal Year: 2010..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura Gonzalez Bosc; Fiscal Year: 2009..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000gROBIN BRITT KNOBEL; Fiscal Year: 2010..We will examine the ability of each infant to exhibit peripheral vasoconstriction in response to decreased abdominal skin temperature and to keep abdominal temperature higher than peripheral ..
- Local Vasoconstriction in Postural Tachycardia SyndromeJulian M Stewart; Fiscal Year: 2010..One type of "Low flow POTS" (LFP) has increased vasoconstriction associated with increased angiotensin-II (Ang- II), reduced nitric oxide (NO), and increased reactive oxygen ..
- Local Calcium Signaling in Pulmonary ArteriesJAMES SHAM; Fiscal Year: 2009..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs; and these ..
- Local Calcium Signaling in Pulmonary ArteriesJAMES SK SHAM; Fiscal Year: 2010..Ca2+ signals that originate from ryanodine receptors (RyRs) play major roles in agonist- and hypoxia-induced vasoconstriction. Our recent study shows that all three RyR subtypes, RyR1, RyR2 and RyR3, are expressed in PASMCs;and these ..
- NFATc3 in chronic hypoxic pulmonary hypertensionLaura Gonzalez Bosc; Fiscal Year: 2009..the origin of pulmonary arterial hypertension (PAH), pulmonary vascular resistance rises due to pulmonary vasoconstriction, arterial remodeling and polycythemia leading to right heart failure and death...
- Oxidant Stress Mechanisms in PreeclampsiaScott W Walsh; Fiscal Year: 2010..Neutrophils infiltrating the vasculature could cause inflammation and vasoconstriction by release of toxic compounds, such as reactive oxygen species (ROS), TNF??and thromboxane...
- Age and Control of Human Skin FlowW Kenney; Fiscal Year: 2009..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
- Age and Control of Human Skin FlowW Larry Kenney; Fiscal Year: 2010..Recently we have examined the mechanisms of age-related attenuated reflex cutaneous vasoconstriction (VC) and vasodilation (VD)...
- ACETAMINOPHEN VS IBUPROFEN ON RENAL FUNCTION DURING EXERCISEW Kenney; Fiscal Year: 1999..resting conditions, PG inhibition with an NSAID has no appreciable effect on renal function because basal vasoconstriction tone is low. However, during exercise, there is both neural and endocrine stimuli (i.e...
- O2 sensing in the human and rabbit ductus arteriosusStephen L Archer; Fiscal Year: 2010..At birth, functional closure of the DA is initiated within minutes by O2-induced vasoconstriction. Functional closure (vasoconstriction) stops right to left shunting of blood and promotes anatomical closure...
- Renal Control of Blood Pressure in Early DiabetesMichael Brands; Fiscal Year: 2007We have shown that the first onset of hyperglycemia in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2007..by HO-1, and demonstrated, along with relevant mechanistic insights, that the HO system inhibits: i) vasoconstriction/ischemia, li) inflammation, and iii) apoptosis. The proposed aims continue these investigative themes...
- Renal Vascular Reactivity in HypertensionWilliam J Arendshorst; Fiscal Year: 2011..angiotensin II (Ang II)-induced hypertension (AIH) and that CD38-deficient mice exhibit less pronounced renal vasoconstriction, Na+ retention and AIH than do wild-type (WT) mice...
- Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.Nancy L Kanagy; Fiscal Year: 2010..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
- Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.Nancy Kanagy; Fiscal Year: 2007..Therefore, we hypothesize that augmented ET-1-mediated vasoconstriction in arteries from rats made hypertensive with IH/HC is caused by increased activation of PKC signaling...
- Aging, Sex, and Neural Cardiovascular Control During Dynamic ExercisePAUL FADEL; Fiscal Year: 2009..Furthermore, since augmented sympathetically-mediated vasoconstriction would not only cause an elevation in BP but may also limit blood flow to active muscle, aim 2 is designed to ..
- Tyrosine Kinases in Renal Vasoconstrictor SignalingPAMELA CARMINES; Fiscal Year: 2007..The primary Na+ retaining hormone, angiotensin II (AngII) elicits preglomerular (and postglomerular) vasoconstriction via engagement of AT1 receptors (AT1R), which provoke G protein-mediated phospholipase C (PLC) activation and ..
- TRP Channel-Dependent Regulation of Arterial ToneScott Earley; Fiscal Year: 2009..of TRPM4 channels causes membrane depolarization, Ca2+ influx via voltage-dependent Ca2+ channels, and vasoconstriction. Thus, TRPM4 appears to be an important mediator of smooth muscle cell depolarization...
- PULMONARY MICROCIRCULATORY HEMODYNAMICSWILTZ WAGNER; Fiscal Year: 1999..largely passive circuit which, nevertheless, is capable of balancing perfusion to ventilation by hypoxic vasoconstriction. With regard to the hemodynamics of the actual gas exchange vessels, however, there are many unexplored areas ..
- Local Vasoconstriction in Postural Tachycardia SyndromeJulian Stewart; Fiscal Year: 2007..Preliminary data indicate that POTS in the young segregates into three groups: a) reduced adrenergic-mediated vasoconstriction producing peripheral vasodilation; b) defective splanchnic venoconstriction producing venous pooling; and c) ..
- Fibrinogen-induced vasoconstriction during hypertensionDavid Lominadze; Fiscal Year: 2009..We reported that binding of Fg to the arterial wall causes vasoconstriction, which is mediated by intercellular adhesion molecule-1 (ICAM-1)...
- INTERCELLULAR COORDINATION OF BLOOD FLOW CONTROLSTEVEN SEGAL; Fiscal Year: 1999..flow; conducted (but not localized) vasodilation increases microvascular perfusion and attenuates sympathetic vasoconstriction. Nevertheless, the signal(s) which underlie conduction are unknown...
- Redistribution of pulmonary perfusion during bronchoconstriction in asthmaROBERT SCOTT HARRIS; Fiscal Year: 2010..are 1) The redistribution of perfusion away from ventilation defects is primarily caused by hypoxic pulmonary vasoconstriction and is not solely an artifact of methacholine-induced bronchoconstriction and 2) For a given degree of ..
- Arterial Baroreflex Control of Blood Pressure (Exercise)Peter Raven; Fiscal Year: 2006..the active muscle open ATP-sensitive potassium (KATP) channels and thereby partially inhibit sympathetic vasoconstriction. However, it has recently been demonstrated that the CBR mediated vasoconstriction within the active muscle ..
- CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICSAlan Stephenson; Fiscal Year: 2002..by selectively increasing vascular resistance to alveoli with reduced oxygen tension (hypoxic pulmonary vasoconstriction, HPV)...