heart rate


Summary: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.

Top Publications

  1. ncbi Beyond heart rate variability: vagal regulation of allostatic systems
    Julian F Thayer
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Ann N Y Acad Sci 1088:361-72. 2006
  2. ncbi The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors
    Julian F Thayer
    The Ohio State University, Department of Psychology, 1835 Neil Avenue, Columbus, Ohio 43210, USA
    Int J Cardiol 141:122-31. 2010
  3. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
  4. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
  5. ncbi Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
  6. ncbi Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure
    Søren Brage
    Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense University, DK 5230 Odense, Denmark
    J Appl Physiol (1985) 96:343-51. 2004
  7. pmc An epidemiological appraisal of the association between heart rate variability and particulate air pollution: a meta-analysis
    Nicky Pieters
    Hasselt University, Agoralaan Gebouw D, Diepenbeek, Belgium
    Heart 98:1127-35. 2012
  8. ncbi Age-predicted maximal heart rate revisited
    H Tanaka
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    J Am Coll Cardiol 37:153-6. 2001
  9. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
  10. ncbi A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health
    Julian F Thayer
    Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 36:747-56. 2012

Detail Information

Publications378 found, 100 shown here

  1. ncbi Beyond heart rate variability: vagal regulation of allostatic systems
    Julian F Thayer
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Ann N Y Acad Sci 1088:361-72. 2006
    ..Decreased vagal function and heart rate variability (HRV) were shown to be associated with increased fasting glucose and hemoglobin A1c levels, ..
  2. ncbi The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors
    Julian F Thayer
    The Ohio State University, Department of Psychology, 1835 Neil Avenue, Columbus, Ohio 43210, USA
    Int J Cardiol 141:122-31. 2010
    ..b>Heart rate variability (HRV) may be used to assess autonomic imbalances, diseases and mortality...
  3. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
    ..There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables...
  4. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
    Components of heart rate variability have attracted considerable attention in psychology and medicine and have become important dependent measures in psychophysiology and behavioral medicine...
  5. ncbi Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
    ..The Actiheart, a combined heart rate (HR) and movement sensor, is designed to assess physical activity in populations.
  6. ncbi Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure
    Søren Brage
    Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense University, DK 5230 Odense, Denmark
    J Appl Physiol (1985) 96:343-51. 2004
    The combination of heart rate (HR) monitoring and movement registration may improve measurement precision of physical activity energy expenditure (PAEE)...
  7. pmc An epidemiological appraisal of the association between heart rate variability and particulate air pollution: a meta-analysis
    Nicky Pieters
    Hasselt University, Agoralaan Gebouw D, Diepenbeek, Belgium
    Heart 98:1127-35. 2012
    Studies on the association between short-term exposure to ambient air pollution and heart rate variability (HRV) suggest that particulate matter (PM) exposure is associated with reductions in measures of HRV, but there is heterogeneity in ..
  8. ncbi Age-predicted maximal heart rate revisited
    H Tanaka
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    J Am Coll Cardiol 37:153-6. 2001
    We sought to determine a generalized equation for predicting maximal heart rate (HRmax) in healthy adults.
  9. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
    ..Elucidating the fractal and nonlinear mechanisms involved in physiologic control and complex signaling networks is emerging as a major challenge in the postgenomic era...
  10. ncbi A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health
    Julian F Thayer
    Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 36:747-56. 2012
    ..Specifically, we performed a meta-analysis of recent neuroimaging studies on the relationship between heart rate variability and regional cerebral blood flow...
  11. ncbi Effect of forest bathing on physiological and psychological responses in young Japanese male subjects
    J Lee
    Centre for Environment, Health and Field Sciences, Chiba University, 6 2 1 Kashiwanoha, Kashiwa City, Chiba Prefecture 277 0882, Japan
    Public Health 125:93-100. 2011
    ..To provide scientific evidence supporting the efficacy of forest bathing as a natural therapy by investigating its physiological benefits using biological indicators in outdoor settings...
  12. ncbi Neural correlates of heart rate variability during emotion
    Richard D Lane
    Department of Psychiatry, University of Arizona, Tucson, AZ, USA
    Neuroimage 44:213-22. 2009
    The vagal (high frequency [HF]) component of heart rate variability (HRV) predicts survival in post-myocardial infarction patients and is considered to reflect vagal antagonism of sympathetic influences...
  13. ncbi Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration
    Julian F Thayer
    The Ohio State University, Department of Psychology, 1835 Neil Avenue, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 33:81-8. 2009
    ..pathways between the amygdala and the sympathetic and parasympathetic medullary output neurons that modulate heart rate and thus heart rate variability...
  14. pmc Natural selective attention: orienting and emotion
    Margaret M Bradley
    Center for the Study of Emotion and Attention, University of Florida, Gainesville, Florida 32611, USA
    Psychophysiology 46:1-11. 2009
    ..Taken together, it is suggested that orienting is mediated by activation of fundamental motivational systems that have evolved to support survival...
  15. pmc Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Exp Physiol 96:1255-61. 2011
    Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear...
  16. ncbi Cardiac interbeat interval dynamics from childhood to senescence : comparison of conventional and new measures based on fractals and chaos theory
    S M Pikkujämsä
    Division of Cardiology, Department of Internal Medicine, University of Oulu, Finland
    Circulation 100:393-9. 1999
    ..interval variability based on fractal scaling and nonlinear dynamics ("chaos theory") may give new insights into heart rate dynamics...
  17. ncbi A comparison of rate control and rhythm control in patients with atrial fibrillation
    D G Wyse
    AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave, Ste 200, Seattle, WA 98121, USA
    N Engl J Med 347:1825-33. 2002
    ..In both approaches, the use of anticoagulant drugs is recommended...
  18. ncbi Multiscale entropy analysis of complex physiologic time series
    Madalena Costa
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Rev Lett 89:068102. 2002
    There has been considerable interest in quantifying the complexity of physiologic time series, such as heart rate. However, traditional algorithms indicate higher complexity for certain pathologic processes associated with random outputs ..
  19. ncbi Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity
    Søren Brage
    MRC Epidemiology Unit, Cambridge CB1 9NL, UK
    J Appl Physiol (1985) 103:682-92. 2007
    Combining accelerometry with heart rate (HR) monitoring may improve precision of physical activity measurement...
  20. ncbi Gaussian process robust regression for noisy heart rate data
    Oliver Stegle
    University of Cambridge, Cambridge CB3 0HE, UK
    IEEE Trans Biomed Eng 55:2143-51. 2008
    b>Heart rate data collected during nonlaboratory conditions present several data-modeling challenges. First, the noise in such data is often poorly described by a simple Gaussian; it has outliers and errors come in bursts...
  21. pmc The polyvagal perspective
    Stephen W Porges
    University of Illinois at Chicago, Brain Body Center, Department of Psychiatry, Chicago, IL 60612, USA
    Biol Psychol 74:116-43. 2007
  22. pmc Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST)
    Rainer Kolloch
    Medizinische Klinik, Evangelisches Krankenhaus Bielefeld, Akademisches Lehrkrankenhaus der Universität Münster, Bielefeld, Germany
    Eur Heart J 29:1327-34. 2008
    To determine the relationship between resting heart rate (RHR) and adverse outcomes in coronary artery disease (CAD) patients treated for hypertension with different RHR-lowering strategies.
  23. ncbi The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy
    J M Huston
    Department of Surgery, Division of General Surgery, Trauma, Surgical Critical Care, and Burns, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    J Intern Med 269:45-53. 2011
    ..Favourable preclinical data support the possibility that nerve stimulators may be added to the future therapeutic armamentarium, possibly replacing some drugs to inhibit cytokines...
  24. ncbi Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health
    Julian F Thayer
    Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH 43210, USA
    Ann Behav Med 37:141-53. 2009
    In the present paper, we describe a model of neurovisceral integration in which a set of neural structures involved in cognitive, affective, and autonomic regulation are related to heart rate variability (HRV) and cognitive performance.
  25. ncbi Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, Australia
    Biol Psychiatry 67:1067-74. 2010
    ..in the likelihood of cardiac events; however, studies investigating the relationship between depression and heart rate variability (HRV) have generally focused on patients with cardiovascular disease (CVD)...
  26. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    ..We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, ..
  27. ncbi Heart rate variability: a review
    U Rajendra Acharya
    Department of ECE, Ngee Ann Polytechnic, 535 Clementi Road, Singapore, Singapore 599 489
    Med Biol Eng Comput 44:1031-51. 2006
    b>Heart rate variability (HRV) is a reliable reflection of the many physiological factors modulating the normal rhythm of the heart...
  28. ncbi Heart rate variability and its relation to prefrontal cognitive function: the effects of training and detraining
    Anita Lill Hansen
    University of Bergen, Department of Psychosocial Science, Christiesgate 12, 5015 Bergen, Norway
    Eur J Appl Physiol 93:263-72. 2004
    The aim of the present study was to investigate the relationship between physical fitness, heart rate variability (HRV) and cognitive function in 37 male sailors from the Royal Norwegian Navy...
  29. ncbi Transcontinental and translational high-tech acupuncture research using computer-based heart rate and "Fire of Life" heart rate variability analysis
    Gerhard Litscher
    Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, TCM Research Center Graz, Medical University of Graz, Auenbruggerplatz 29, Austria
    J Acupunct Meridian Stud 3:156-64. 2010
    ..Today, new computer-based methods (e.g., "Fire of Life" analysis) allow quantification of heart rate and heart rate variability during acupuncture...
  30. ncbi Fractal correlation properties of R-R interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction
    H V Huikuri
    Division of Cardiology, Department of Medicine, University of Oulu, Finland
    Circulation 101:47-53. 2000
    ..The purpose of this study was to compare the prognostic power of new fractal and traditional measures of R-R interval variability as predictors of death after acute myocardial infarction...
  31. ncbi Physiological background of the loss of fractal heart rate dynamics
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Kasarmintie 13, PO Box 404, FIN 90101 Oulu, Finland
    Circulation 112:314-9. 2005
    Altered fractal heart rate (HR) dynamics occur during various disease states, but the physiological background of abnormal fractal HR behavior is not well known...
  32. ncbi Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients
    Maria Teresa La Rovere
    Divisione di Cardiologia e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Pavia, Italy
    Circulation 107:565-70. 2003
    The predictive value of heart rate variability (HRV) in chronic heart failure (CHF) has never been tested in a comprehensive multivariate model using short-term laboratory recordings designed to avoid the confounding effects of ..
  33. ncbi Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial
    Kim Fox
    Royal Brompton Hospital, London, UK
    Lancet 372:817-21. 2008
    The BEAUTIFUL study assessed the morbidity and mortality benefits of the heart rate-lowering agent ivabradine...
  34. ncbi Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
    Karl Swedberg
    Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Lancet 376:875-85. 2010
    Chronic heart failure is associated with high mortality and morbidity. Raised resting heart rate is a risk factor for adverse outcomes...
  35. ncbi Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    Amal K Bose
    The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, Grafton Way, London WC1E, UK
    Diabetes 54:146-51. 2005
    ..This protection appears to involve activating multiple prosurvival kinases. This finding may represent a new therapeutic potential for this class of drug currently undergoing clinical trials in the treatment of type 2 diabetes...
  36. ncbi Heart rate variability and myocardial infarction: systematic literature review and metanalysis
    E Buccelletti
    Department of Emergency Medicine, Catholic University of the Sacred Hearth, Rome, Italy
    Eur Rev Med Pharmacol Sci 13:299-307. 2009
    b>Heart rate, measured as beat-to-beat intervals, is not constant and varies in time. This property is known as heart rate variability (HRV) and it has been investigated in several diseases, including myocardial infarction (MI)...
  37. ncbi Heart-rate profile during exercise as a predictor of sudden death
    Xavier Jouven
    Service de cardiologie, Faculté René Descartes, Universite Paris 5, Hopital Europeen Georges Pompidou, Paris, France
    N Engl J Med 352:1951-8. 2005
    Changes in heart rate during exercise and recovery from exercise are mediated by the balance between sympathetic and vagal activity...
  38. pmc Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
    A Bucchi
    Laboratory of Molecular Physiology and Neurobiology, Department of Biomolecular Sciences and Biotechnology, University of Milano, Italy
    J Physiol 572:335-46. 2006
    Ivabradine is a 'heart rate-reducing' agent able to slow heart rate, without complicating side-effects. Its action results from a selective and specific block of pacemaker f-channels of the cardiac sinoatrial node (SAN)...
  39. ncbi Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester School of Medicine, and the Leicester NIHR Cardiovascular Biomedical Research Unit, Leicester, UK
    J Am Coll Cardiol 54:705-13. 2009
    ..The present study examined the importance of heart rate (HR) as a determinant of this effect.
  40. ncbi Why socially deprived populations have a faster resting heart rate: impact of behaviour, life course anthropometry, and biology--the RECORD Cohort Study
    Basile Chaix
    INSERM U707, Paris, France
    Soc Sci Med 73:1543-50. 2011
    Although studies have shown that resting heart rate (RHR) is predictive of cardiovascular morbidity/mortality, few studies focused on the epidemiology and social aetiology of RHR...
  41. ncbi Longitudinal modeling of the relationship between age and maximal heart rate
    Ronald L Gellish
    School of Health Sciences, Oakland University, Rochester, MI 44309 4482, USA
    Med Sci Sports Exerc 39:822-9. 2007
    Maximal heart rate (HRmax)-prediction equations based on a person's age are frequently used in prescribing exercise intensity and other clinical applications...
  42. ncbi Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge
    P J Whalen
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurosci 18:411-8. 1998
    ..This study, using fMRI in conjunction with masked stimulus presentations, represents an initial step toward determining the role of the amygdala in nonconscious processing...
  43. pmc An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation
    Stefano Severi
    Biomedical Engineering Laboratory DEIS, University of Bologna, Via Venezia 52, 47521 Cesena, Italy
    J Physiol 590:4483-99. 2012
    ..SAN AP model, based on available experimental data, in an attempt to reproduce physiological and pharmacological heart rate modulation...
  44. pmc The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy
    Evgeniya Kirilina
    Free Univ Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
    Neuroimage 61:70-81. 2012
    ..We used complementary fNIRS, fMRI, MR-angiography and peripheral physiological measurements (blood pressure, heart rate, skin conductance and skin blood flow) to study activation in the frontal lobe during a continuous performance ..
  45. ncbi Cardiovascular effects of secondhand smoke: nearly as large as smoking
    Joaquin Barnoya
    Center for Tobacco Control Research and Education, Cardiovascular Research Institute, and Division of Cardiology, University of California, San Francisco 94143 1390, USA
    Circulation 111:2684-98. 2005
    ..This effect is larger than one would expect on the basis of the risks associated with active smoking and the relative doses of tobacco smoke delivered to smokers and nonsmokers...
  46. ncbi Cardiovascular effects of human insular cortex stimulation
    S M Oppenheimer
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Neurology 42:1727-32. 1992
    ..These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death...
  47. pmc A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
    Edward G Lakatta
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
    Circ Res 106:659-73. 2010
    ..This review examines evidence that forms the basis of this coupled-clock system concept in cardiac SANCs...
  48. ncbi Association between arterial stiffness and atherosclerosis: the Rotterdam Study
    N M van Popele
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam (Netherlands
    Stroke 32:454-60. 2001
    ..Data were analyzed by ANCOVA with adjustment for age, sex, mean arterial pressure, and heart rate. RESULTS: Both aortic and common carotid artery stiffness were found to have a strong positive association with ..
  49. pmc Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1562-8. 2011
    ..RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure...
  50. pmc Acute effect of a single high-fat meal on forearm blood flow, blood pressure and heart rate in healthy male Asians and Caucasians: a pilot study
    Chumjit Bui
    Department of Health Promotion and Education, School of Public Health, Loma Linda University, Loma Linda, CA, USA
    Southeast Asian J Trop Med Public Health 41:490-500. 2010
    ..These findings suggest that a single HF meal may contribute to the detrimental effects on vascular health in Asian males and raises speculation regarding the cumulative impact of a chronic HF diet in this population...
  51. ncbi The role of vagal function in the risk for cardiovascular disease and mortality
    Julian F Thayer
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Biol Psychol 74:224-42. 2007
    ..Using a broad range of indicators of vagal function including resting heart rate, heart rate recovery, heart rate variability, and baroreflex sensitivity we show that decreased vagal function ..
  52. ncbi Impaired exercise performance in the heat is associated with an anticipatory reduction in skeletal muscle recruitment
    Ross Tucker
    MRC UCT Bioenergetics of Exercise Research Unit, University of Cape Town, Sports Science Institute of South Africa, PO Box 115, 7725, Newlands, South Africa
    Pflugers Arch 448:422-30. 2004
    ..during self-paced exercise in the heat occurs before there is any abnormal increase in rectal temperature, heart rate or perception of effort...
  53. ncbi Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    It is generally accepted that cardiac sympathetic tone dominates the control of heart rate (HR) in mice...
  54. ncbi Cardiovascular, electrodermal, and respiratory response patterns to fear- and sadness-inducing films
    Sylvia D Kreibig
    Department of Psychology, Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland
    Psychophysiology 44:787-806. 2007
    Responses to fear- and sadness-inducing films were assessed using a broad range of cardiovascular (heart rate, T-wave amplitude, low- and high-frequency heart rate variability, stroke volume, preejection period, left-ventricular ejection ..
  55. ncbi Nocturnal hypertension in mice consuming a high fructose diet
    Vera Farah
    Boonshoft School of Medicine of Wright State University, Department of Pharmacology and Toxicology, Dayton, OH 45401, USA
    Auton Neurosci 130:41-50. 2006
    To investigate the effect of fructose consumption on the light/dark pattern of blood pressure, heart rate and autonomic neural function in mice.
  56. ncbi Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) study
    Jorg Carlsson
    Department of Internal Medicine II, Klinikum Lippe Detmold, Röntgenstrasse 18, D 32760 Detmold, Germany
    J Am Coll Cardiol 41:1690-6. 2003
  57. pmc Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:1578-84. 2010
  58. ncbi Plasma leptin concentrations and cardiac autonomic nervous system in healthy subjects with different body weights
    G Paolisso
    Department of Geriatric Medicine and Metabolic Diseases II, University of Naples, Italy
    J Clin Endocrinol Metab 85:1810-4. 2000
    Previous studies have shown that leptin stimulates sympathetic nervous system; heart rate variability (HRV) is a widely used technique for assessing the sympathovagal balance at the cardiac level...
  59. ncbi An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone
    Bruce H Friedman
    Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0436, USA
    Biol Psychol 74:185-99. 2007
    Research on heart rate variability (HRV), cardiac vagal tone, and their relationship to anxiety is reviewed in the context of the autonomic flexibility and neurovisceral integration models of adaptive functioning...
  60. pmc Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Peter De Jonge
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Psychosom Med 69:735-9. 2007
    To determine if depression associated with low heart rate variability (HRV) in patients post myocardial infarction (MI), but not in patients with stable coronary heart disease (CHD), may be the result of differential associations of ..
  61. pmc Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk
    Andrew H Kemp
    School of Psychology, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e30777. 2012
    There is evidence that heart rate variability (HRV) is reduced in major depressive disorder (MDD), although there is debate about whether this effect is caused by medication or the disorder per se...
  62. ncbi Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease
    Ahmad Sajadieh
    Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg Bakke 23, Copenhagen NV 2400, Denmark
    Eur Heart J 25:363-70. 2004
    Elevation of inflammation markers, high heart rate, and reduced heart-rate variability are all strong markers of mortality in a broad spectrum of patients. The association between these markers has not been clarified thoroughly...
  63. ncbi Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart
    Daniel R Messroghli
    Cardiac MRI Unit, Franz Volhard Klinik, Charite Campus Buch, Universitatsmedizin Berlin, HELIOS Klinikum Berlin, Germany
    J Magn Reson Imaging 26:1081-6. 2007
    ..To optimize and validate a fully-integrated version of modified Look-Locker inversion-recovery (MOLLI) for clinical single-breathhold cardiac T1 mapping...
  64. ncbi Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:1945-52. 2005
    The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans.
  65. ncbi Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction
    G Schmidt
    Erste Medizinische Klinik, Technischen Universitat Munchen, Germany
    Lancet 353:1390-6. 1999
    ..Thus, establishment of a new powerful method for risk prediction independent of the available stratifiers is of considerable practical value...
  66. ncbi The relationship between heart rate variability and inflammatory markers in cardiovascular diseases
    Alexander Haensel
    Department of General Internal Medicine, University Hospital Berne, Switzerland
    Psychoneuroendocrinology 33:1305-12. 2008
    Recent evidence implicates a cholinergic anti-inflammatory pathway. Because vagus nerve activity mediates some heart rate variability (HRV), this qualitative review examines the literature concerning circulating cytokines and HRV in ..
  67. ncbi Heart rate variability explored in the frequency domain: a tool to investigate the link between heart and behavior
    Nicola Montano
    Department of Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Neurosci Biobehav Rev 33:71-80. 2009
    ..Spectral analysis of cardiovascular signal variability, and in particular of RR period (heart rate variability, HRV), is a widely used procedure to investigate autonomic cardiovascular control and/or target ..
  68. ncbi Effects of resting heart rate variability on performance in the P300 brain-computer interface
    Tobias Kaufmann
    Department of Psychology I, University of Wurzburg, Marcustrasse 9 11, Wurzburg, Germany
    Int J Psychophysiol 83:336-41. 2012
    ..Such inhibitory control has been closely linked to peripheral physiological parameters, such as heart rate variability (HRV)...
  69. ncbi Modulation of blood pressure by central melanocortinergic pathways
    Jerry R Greenfield
    University of Cambridge Metabolic Research Laboratories, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 360:44-52. 2009
    ..Central melanocortinergic signaling is implicated in the control of energy balance and blood pressure in rodents, but there is no information regarding such an association with blood pressure in humans...
  70. ncbi The utility of low frequency heart rate variability as an index of sympathetic cardiac tone: a review with emphasis on a reanalysis of previous studies
    Gustavo A Reyes del Paso
    Department of Psychology, University of Jaen, Jaen, Spain
    Psychophysiology 50:477-87. 2013
    This article evaluates the suitability of low frequency (LF) heart rate variability (HRV) as an index of sympathetic cardiac control and the LF/high frequency (HF) ratio as an index of autonomic balance...
  71. ncbi The effects of [omega]3 fatty acids and coenzyme Q10 on blood pressure and heart rate in chronic kidney disease: a randomized controlled trial
    Trevor A Mori
    University of Western Australia and the Cardiovascular Research Centre, Perth, Western Australia
    J Hypertens 27:1863-72. 2009
    ..Omega-3 fatty acids (omger3FA) protect against CVD via improvements in blood pressure, heart rate, vascular reactivity and serum lipids. Coenzyme Q(10) (CoQ) may improve blood pressure and vascular function...
  72. ncbi Genesis and regulation of the heart automaticity
    Matteo E Mangoni
    Institute of Functional Genomics, Department of Physiology, Centre National de la Recherche Scientifique UMR5203, INSERM U661, University of Montpellier I and II, Montpellier, France
    Physiol Rev 88:919-82. 2008
    ..been indicated as an important mechanism for promoting automaticity at rest as well as for acceleration of the heart rate under sympathetic nerve input...
  73. ncbi More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women
    Kathleen C Light
    Department of Psychiatry, University of North Carolina, CB 7175 Medical Building A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:5-21. 2005
    ..Higher baseline OT before partner contact was associated with lower BP and heart rate, and met criteria to be a partial mediator of the lower resting BP shown by women reporting more frequent hugs (..
  74. pmc Ambient temperature, air pollution, and heart rate variability in an aging population
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Am J Epidemiol 173:1013-21. 2011
    ..The authors examined whether temperature was associated with heart rate variability (HRV) in a Boston, Massachusetts, study population and whether such associations were modified by ..
  75. pmc Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice
    A Drouin
    Montreal Heart Institute, Research Center, Faculty of Medicine, Department of Surgery, Universite de Montreal, Montreal, Quebec, Canada
    Br J Pharmacol 154:749-57. 2008
    High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with coronary artery disease...
  76. ncbi Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution and biobehavioral functions
    Paul Grossman
    Department of Psychosomatic and Internal Medicine, Psychophysiology Research Laboratory, University of Basel Hospital, Hebelstrasse 2, CH 4031 Basel, Switzerland
    Biol Psychol 74:263-85. 2007
    ..Finally, a recent hypothesis is expanded upon, in which RSA plays a primary role in regulation of energy exchange by means of synchronizing respiratory and cardiovascular processes during metabolic and behavioral change...
  77. ncbi Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics
    K K Ho
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215 5491, USA
    Circulation 96:842-8. 1997
    Despite much recent interest in quantification of heart rate variability (HRV), the prognostic value of conventional measures of HRV and of newer indices based on nonlinear dynamics is not universally accepted.
  78. ncbi Ventral medial prefrontal cortex and cardiovagal control in conscious humans
    Savio W Wong
    Neurovascular Research Laboratory, School of Kinesiology, The University of Western Ontario, London, ON, Canada N6A 3K7
    Neuroimage 35:698-708. 2007
    ..Seventeen healthy individuals performed graded handgrip exercise while heart rate (HR) and cortical activity were recorded...
  79. ncbi Accuracy and validity of a combined heart rate and motion sensor for the measurement of free-living physical activity energy expenditure in adults in Cameroon
    Felix K Assah
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Int J Epidemiol 40:112-20. 2011
    ..Combined heart rate (HR) and movement monitoring make it possible to objectively measure physical activity in free-living ..
  80. ncbi [Geometric index of heart rate variability in chronic obstructive pulmonary disease]
    T Dias de Carvalho
    Departamento de Fisioterapia, Universidade Estadual Paulista, Presidente Prudente, SP, Brazil
    Rev Port Pneumol 17:260-5. 2011
    It was already evidenced decreased heart rate variability (HRV) in chronic obstructive pulmonary disease (COPD) patients at rest.
  81. pmc Is heart rate variability related to memory performance in middle-aged men?
    Amit Jasvant Shah
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Psychosom Med 73:475-82. 2011
    b>Heart rate variability (HRV), a measure of autonomic function, has been associated with cognitive function, but studies are conflicting. Previous studies have also not controlled for familial and genetic influences.
  82. ncbi Health benefits of a pedometer-based physical activity intervention in sedentary workers
    Catherine B Chan
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3
    Prev Med 39:1215-22. 2004
    ..Here, we examined the effects of a pedometer-based physical activity intervention (Prince Edward Island-First Step Program, PEI-FSP) on activity and specific health indices in 106 sedentary workers...
  83. ncbi Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability
    Hendrik Bonnemeier
    Medizinische Kinik II, Medizinische Universitat zu Lubeck, Lubeck, Germany
    J Cardiovasc Electrophysiol 14:791-9. 2003
    Circadian Profile of Heart Rate Variability.
  84. ncbi Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter
    Bramah N Singh
    Cardiology Division, Veterans Affairs Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    N Engl J Med 357:987-99. 2007
    ..Dronedarone is a new antiarrhythmic agent pharmacologically related to amiodarone but developed to reduce the risk of side effects...
  85. ncbi Heart rate variability as a measure of autonomic regulation of cardiac activity for assessing stress and welfare in farm animals -- a review
    Eberhard von Borell
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, 06108 Halle, Germany
    Physiol Behav 92:293-316. 2007
    Measurement of heart rate variability (HRV) is a non-invasive technique that can be used to investigate the functioning of the autonomic nervous system, especially the balance between sympathetic and vagal activity...
  86. ncbi Comparison of PAEE from combined and separate heart rate and movement models in children
    Kirsten Corder
    Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    Med Sci Sports Exerc 37:1761-7. 2005
    Accurate measurement of physical activity in children is a challenge. Combining physiological (e.g., heart rate (HR)) and body movement registration (e.g., accelerometry) may overcome limitations with either method used alone...
  87. ncbi Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day
    Brigitte M Kudielka
    Department of Behavioral Sciences, Swiss Federal Institute of Technology ETH, Turnerstr 1, CH 8092 Zurich, Switzerland
    Psychoneuroendocrinology 29:983-92. 2004
    ..02), total plasma cortisol (p < 0.0001), and marginally ACTH (p = 0.09). Stress-related heart rate increases did not differ between groups (p = n.s.)...
  88. ncbi High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light
    Christian Cajochen
    Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr 27, CH 4025 Basel, Switzerland
    J Clin Endocrinol Metab 90:1311-6. 2005
    ..Here, we report that the alerting response of light as well as its effects on thermoregulation and heart rate are also wavelength dependent...
  89. ncbi Bioengineering assessment of acupuncture, part 7: heart rate variability
    Gerhard Litscher
    Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and Traditional Chinese Medicine TCM Research Center, Medical University of Graz, Graz, Austria
    Crit Rev Biomed Eng 35:183-95. 2007
    In the seventh part of this review article, preliminary research on the topic of acupuncture and heart rate variability is described. Heart rate variability (HRV) refers to the beat-to-beat alterations in heart rate...
  90. ncbi Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats
    Meihua Li
    Department of Cardiovascular Dynamics, Cardiovascular Center Research Institute, Suita, Japan
    Circulation 109:120-4. 2004
    Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction...
  91. pmc Cardiovascular and autonomic phenotype of db/db diabetic mice
    Danielle Senador
    Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA
    Exp Physiol 94:648-58. 2009
    ..Parameters measured were mean arterial pressure (MAP), heart rate (HR) and their variabilities...
  92. ncbi Effect of aging on gender differences in neural control of heart rate
    T B Kuo
    Institute of Neuroscience, Tzu Chi College of Medicine and Humanities, Hualien 970, Taiwan, Republic of China
    Am J Physiol 277:H2233-9. 1999
    To clarify the influence of gender on sympathetic and parasympathetic control of heart rate in middle-aged subjects and on the subsequent aging process, heart rate variability (HRV) was studied in normal populations of women (n = 598) and ..
  93. ncbi Dietary fish oil reduces pacemaker current and heart rate in rabbit
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1485-92. 2009
    Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil (FO) reduce heart rate in humans. The mechanism underlying this cardioprotective effect of FO is unknown.
  94. ncbi An advanced detrending method with application to HRV analysis
    Mika P Tarvainen
    University of Kuopio, Department of Applied Physics, Finland
    IEEE Trans Biomed Eng 49:172-5. 2002
    An advanced, simple to use, detrending method to be used before heart rate variability analysis (HRV) is presented...
  95. ncbi Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    JAMA 297:2081-91. 2007
    ..However, a poor understanding of the physical activity-fitness dose response relation remains...
  96. ncbi Software for advanced HRV analysis
    Juha Pekka Niskanen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Comput Methods Programs Biomed 76:73-81. 2004
    A computer program for advanced heart rate variability (HRV) analysis is presented. The program calculates all the commonly used time- and frequency-domain measures of HRV as well as the nonlinear Poincaré plot...
  97. ncbi A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    Matthias Manz
    Department of Cardiology, Marienhof Hospital, Koblenz, Germany
    Cardiology 100:149-55. 2003
    This randomized, single-blind, placebo-controlled study investigated the effect of ivabradine, a novel heart rate-lowering agent, on echocardiographic indices of left ventricular (LV) systolic function in patients with regional (coronary ..
  98. pmc Detection of driver drowsiness using wavelet analysis of heart rate variability and a support vector machine classifier
    Gang Li
    Department of Electronic Engineering, Pukyong National University, Busan 608 737, Korea
    Sensors (Basel) 13:16494-511. 2013
    Driving while fatigued is just as dangerous as drunk driving and may result in car accidents. Heart rate variability (HRV) analysis has been studied recently for the detection of driver drowsiness...
  99. ncbi Heart rate variability: measurement and clinical utility
    Robert E Kleiger
    Washington University School of Medicine, St Louis, MO, USA
    Ann Noninvasive Electrocardiol 10:88-101. 2005
    ..g., exercise or drugs. RR interval variability is useful for assessing risk of cardiovascular death or arrhythmic events, especially when combined with other tests, e.g., left ventricular ejection fraction or ventricular arrhythmias...
  100. ncbi Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans
    M Pagani
    Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale L Sacco, Universita di Milano, Italy
    Circulation 95:1441-8. 1997
    ..Spectral analysis of RR interval and systolic arterial pressure variabilities may provide indirect markers of the balance between sympathetic and vagal cardiovascular control...

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..We have identified that chromogranin A (Chga)-derived peptide, catestatin (CST), lowers blood pressure (BP) and heart rate (HR) by inhibiting release of catecholamines...
  3. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..pressure (BP) will be recorded continuously over 24hrs and cardiac sympathetic activity will be assessed by heart rate variability of ambulatory EKG recordings...
  4. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Aim #4: Over a 4 h period, we will monitor peripheral arterial blood pressure and heart rate in anesthetized endotoxinemic mice treated with vehicle control or R-100 administered 1 h after LPS challenge, ..
  5. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..monitor activity intensity using a wearable device that contains a motion-sensing accelerometer and heart rate monitor...
  6. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..Blood pressure, heart rate, locomotor activity and an array of autonomic indices will be measured in conscious mice implanted with blood ..
  7. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..of affect and mood regulation, 4) body awareness, 5) quality of life, 6) health care utilization, 7) resting heart rate (HR) and heart rate variability (HRV). 1 Saper, R.B., Eisenberg, D.M., Davis, R.B., Culpepper, L., Phillips, R.S...
  8. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..From the ECG, we extract heart rate variability (HRV) and ECG R-wave amplitude fluctuations associated with respiratory tidal volume changes (the ..
  9. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory volume (FEV1), and BMI...
  10. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..anesthetized cats to stimulate 5- hydroxytryptamine-3 (5-HT3) cardiopulmonary receptors to reflexly lower heart rate and blood pressure through pathways in the medial nucleus tractus solitarii (mNTS) and nucleus ambiguus (NA)...
  11. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..5. Generate apparatus for heart rate and blood pressure measurements in the rat to determine the impact of the vestibule-sympathetic reflex during ..
  12. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..The purpose will be to evaluate muscles used, active range of motion, forces generated, heart rate, and other measurable attributes of the actions used during interactive video gaming play...
  13. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..nervous system activity (PNSA) could ultimately lead to persistent increases in blood pressure and heart rate abnormalities...
  14. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..We will monitor hemodynamic status by tracking heart rate, mean arterial pressure, and arterial pulse pressure variation...
  15. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..Multiple physiologic variables (such as core temperature, blood pressure, and heart rate) will be collected by chronic catheterization or telemetry...
  16. Respiratory motor control and blood pressure regulation after spinal cord injury
    ..In addition, we will use continuous beat-to-beat recording of systemic arterial blood pressure, heart rate, cardiac output, and the measurements of blood catecholamines level during orthostatic stress test...
  17. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..While TH excess leads to deleterious effects such as elevated heart rate, arrythmias and muscle and bone catabolism there are beneficial effects such as reduced cholesterol and fat loss...
  18. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..AIM 2: To determine the effect of myofilament Ca2+ sensitization on the ventricular action potential and its heart rate dependence AIM 3: To determine the effect of myofilament Ca2+ sensitization on cell-cell coupling and on ..
  19. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ..conducting experiments to answer these questions include: chronic telemetric measurements of blood pressure and heart rate in rats and mice, in vitro imaging of rat paraventricular nucleus neurons to determine the effects of estrogen ..
  20. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    ..spirometry, pulse oximetry, dyspnea, respiration rate, 6-Minute Walk test);oxygenation (pulse oximetry;heart rate);stress (Perceived Stress Scale;diurnal salivary cortisol);mood (Profile of Mood States-Brief);sleep (Pittsburgh ..
  21. Purinergic Regulation of Bone Metabolism
    Bruce Neil Cronstein; Fiscal Year: 2013
    The purine nucleoside adenosine regulates such physiologic functions as heart rate, vasodilation and inflammation and receptors for adenosine have been targeted for such diverse conditions as Parkinson's Disease and, indirectly, ..
  22. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..The autonomic nervous system regulates critical cardiac parameters such as excitability, heart rate, force of contraction, conduction velocity and refractoriness...
  23. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..In addition to our battery of existing measurements of respiration, heart rate, blood pressure, movement, EEG and temperature, we propose to incorporate new state of the art measures of ..
  24. PTSD Hyperarousal Symptoms Treated with Physiological Stress Management
    WALTON THOMPSON ROTH; Fiscal Year: 2011
    ..Measurements will be both physiological, using 24 hour ambulatory monitoring of skin conductance, heart rate, and physical activity during waking and sleeping, and psychological, using self-reports and clinician ..
  25. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    RODICA BUSUI POP-BUSUI; Fiscal Year: 2013
    ..activation will be determined by positron emission tomography (PET) with [11C]meta-hydroxyephedrine ([11C]HED), heart rate variability, and 24-hour blood pressure monitoring in patients with T1DM (5-10 years'diabetes duration)...
  26. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..We will expose adult and neonatal mice to hypercapnia and hypoxia, and measure ventilation, heart rate, motor activity and EEG...
  27. Reducing Care-Resistant Behaviors During Oral Hygiene in Persons with Dementia
    Rita A Jablonski; Fiscal Year: 2013
    ..These responses are both autonomic (e.g. elevated heart rate, sweating) and behavioral (e.g. moving away, attacking)...
  28. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..The autonomic nervous system regulates critical cardiac parameters such as excitability, heart rate, force of contraction, conduction velocity and refractoriness...
  29. Mechanisms and Therapeutics for Rett Syndrome
    Mriganka Sur; Fiscal Year: 2013
    ..physiology of the animals along metrics of maturation in central control systems, including locomotion, heart rate, respiration, and survival rates...
  30. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ..We propose to use indirect calorimetry and a telemetry-based heart rate and body temperature detection system to measure these physiological variables in mice at different ambient ..
  31. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The presence of an irregular heart rate (atrial fibrillation) is associated with 1/3 of the strokes in the general population and is related to ..
    David Mendelowitz; Fiscal Year: 2013
    ..CIH impairs the baroreflex control of heart rate and diminishes cardioprotective parasympathetic activity to the heart and current research indicates these ..
  33. Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects
    Mark W Frampton; Fiscal Year: 2010
    ..Systemic vascular function will be assessed using blood pressure and heart rate, forearm plethysmography and reactive hyperemia, platelet activation, and circulating microparticles...
  34. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..Electrical or mechanical stimulation of the trigeminal nerve evokes a dramatic decrease in heart rate in animals including man, and has often been termed the `trigeminocardiac reflex'in the clinical literature,..
  35. Stress and Subclinical Cardio-Metabolic Disease in Police: A Longitudinal Study
    John M Violanti; Fiscal Year: 2013
    ..Markers of disease include blood pressure;laboratory measurement of lipids, glucose, and insulin;heart rate variability to assess autonomic nervous system function;ultrasound imaging studies to measure carotid artery ..
  36. Effect of Baclofen on Alcohol Cue-Elicited Urges to Drink and Smoke
    GEORGE ANTHONY KENNA; Fiscal Year: 2011
    ..Attention to the sight and smell of cues and psychophysiological responses (heart rate, mean arterial pressure and salivation changes) will also be assessed during the CR experiment...
  37. Sex Differences in Myocardial Ischemia Triggered by Emotional Factors after MI
    Viola Vaccarino; Fiscal Year: 2010
    ..sex differences in ischemia induced by emotional stress, including differences in hemodynamic (blood pressure, heart rate), neurobiological (cortisol and autonomic nervous system) and inflammatory responses to the stressful challenge...
  38. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..factor alpha [TNF-alpha]) in children;and 3) Exposures, cadmium, or arsenic are inversely associated with heart rate variability in children...
  39. Stress and PTSD Among OEF/OIF Soldiers &Their Spouses
    Catherine M Caska; Fiscal Year: 2012
    ..Specifically, it will assess the association of PTSD and cardiovascular reactivity (CVR;i.e., increases in heart rate and blood pressure) during potentially stressful marital interactions...
  40. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..Measures of subjective craving, emotion, physiological arousal (e.g., heart rate) and stress (e.g...
  41. Hostility, PTSD and Physical Health Risk Factors
    Jean C Beckham; Fiscal Year: 2013
    ..Findings that ambulatory heart rate is higher, and blood pressure recovery to a stressful task is slower in hostile veterans with PTSD suggest that ..
  42. Ecstasy and the Dorsomedial Hypothalamus
    Daniel E Rusyniak; Fiscal Year: 2010
    ..These effects include increases in heart rate (HR), mean arterial pressure (MAP), temperature, plasma ACTH and locomotor activity...
  43. Mechanisms of Meditation in Hypertension in Blacks
    Robert Schneider; Fiscal Year: 2010
    ..assess cardiovascular and plasma catecholamine reactivity to lab stressors;hemodynamic responses, comprising heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance;arterial compliance, and cardiac ..
  44. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..ultrasonic corneal pachymetry of central corneal thickness, height, weight, body mass index, blood pressure, heart rate, medical history, visual field testing (using standard automated perimetry), Fourier domain Doppler optical ..
  45. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..regulating the activity in the thermoregulatory pathways mediating the increases in BAT thermogenesis, heart rate and CVC contributing to the febrile response to PGE2 in the POA and to cold defense responses to skin cooling...
    Kathleen C Light; Fiscal Year: 2013
    ..show dysregulation of these receptors in CFS after 25 min of moderate exercise (at 70% of age-predicted maximum heart rate). Using blood samples from 0...
  47. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..of extremely pre-term neonates relies on the traditional methods of monitoring such as arterial blood pressure, heart rate, pulse oximetry, urine output and evidence of metabolic acidosis...
  48. The baroreflex in pregnancy: effects of adrenal and placental steroids
    Maureen Keller-Wood; Fiscal Year: 2012
    ..In nonpregnant ewes cortisol increases blood pressure and heart rate, and decreases baroreflex sensitvity;adrenalectomy and total withdrawal from adrenal steroids causes decreased ..
  49. CaMKII in Sinus Node Physiology and Disease
    Mark E Anderson; Fiscal Year: 2013
    ..protein kinase II (CaMKII) as a necessary signal for physiological, 'fight or flight', increases in heart rate. We showed that the cellular mechanisms for CaMKII actions on heart rate were related to increasing sarcoplasmic ..
  50. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..To determine their safety, we will monitor physiological parameters (e.g., arterial blood pressure, heart rate, heart rate variability, and respiration rate) during an immediately after stimulation and will follow-up ..
  51. The Effect of Maternal Stress on Perinatal Development
    LISA J ECKLUND-FLORES; Fiscal Year: 2011
    ..Previous studies have shown that maternal anxiety and depression influence fetal heart rate reactivity...
  52. Blood Pressure Regulation by the Circadian Clock Protein Per1
    Michelle L Gumz; Fiscal Year: 2013
    ..are known to peak with a circadian pattern and have been linked to the morning increase in blood pressure and heart rate. Indeed, many physiological processes exhibit a circadian pattern, including the sleep- wake cycle, heartbeat, ..
  53. Gender differences in aortic baroreceptor function and neural integration
    John H Schild; Fiscal Year: 2013
    ..and unmyelinated BR afferents and the manner in which this defines the strikingly different reflex control of heart rate and blood pressure evoked by these neuroanatomically distinct afferent pathways...
    ROBERT DAVID BEECH; Fiscal Year: 2010
    ..Alcohol craving, anxiety and emotion ratings, behavioral distress responses, heart rate, blood pressure, and salivary cortisol measures will be assessed during each session...
  55. Impact of an Indoor Stove Intervention on Indicators of Cardiorespiratory Health
    Jennifer L Peel; Fiscal Year: 2012
    ..stove, and then examine improved stove use in relation to changes in health indicators (inflammatory markers, heart rate, blood pressure, lung function, and symptoms);(3) Compare air pollution concentrations of indoor fine ..
  56. Gender Specific Complications of Diabetic Autonomic Neuropathy: A New Mouse Model
    JONAS BERNARD GALPER; Fiscal Year: 2010
    ..Comparison of heart rate variability showed that the parasympathetic response of the heart was increased in young women compared with men;..
  57. Attenuation of cardiac parasympathetic nerve acetylcholine release in obesity by
    Wohaib Hasan; Fiscal Year: 2012
    ..In addition, increased heart rate and plasma catecholamines, and reduced heart rate variability in obesity are due to altered cardiac autonomic ..
  58. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..In Specific Aim 1, a dose response study will be conducted by taking physiological (heart rate, blood pressure, and hand tremor) and psychological measurements in response to administration of placebo and ..
  59. Developing Radiological Risk Communication Materials for Low-Literacy Populations
    SARAH B BASS; Fiscal Year: 2010
    ..to these materials will then be tested using psycho- physiological measures (eye-tracking, pupil dilation, heart rate, respiration rate, skin conductance and body temperature) to assess their effectiveness in reducing fear and ..
  60. Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych Mechanisms
    Susan S Girdler; Fiscal Year: 2013
    ..will be assessed at rest and in response to mental stress: 1) sympathetic nervous system (blood pressure, heart rate, plasma norepinephrine and epinephrine);2) hypothalamic-pituitary-adrenal (plasma ACTH and cortisol);3) ..
  61. Take Heart: Exercise & Diet Intervention for Heart Failure in Cancer Survivors
    ELIE MOUHAYAR; Fiscal Year: 2010
    ..The goal will be for patients to work up to at least 30 minutes of exercise 3 times a week at 60-70 percent or heart rate reserve...
  62. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Sympathetic and parasympathetic modulation of heart rate, conduction of the specialized conduction system and ventricular myocardium, AP upstroke velocity, APDs, DOR, ..
  63. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..Diminished autonomic cardiovascular control following SCI can result in abnormal blood pressure, blood flow and heart rate, the degree of which may or may not be related to the level and completeness of SCI (3, 4)...
  64. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ..Our hypothesis will be tested by the following specific aims: #1) We will determine ANS balance, measured by heart rate variability, before, during, and after DMT;#2) We will compare the relationships between ANS balance and HPA ..
  65. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..A broader spectrum of autonomic signs, including changes in heart rate and rhythm (most often bradycardia), blood pressure (most often pressure increases), pupillary size, vasomotor ..
    James Woods; Fiscal Year: 1993
    Cocaine produces increases in blood pressure and heart rate by interfering with the uptake and degradation of norepinephrine at adrenergic nerve terminals...
  67. Integrative Cardiovascular Control During Exercise in Hypertension
    DONAL S O apos LEARY; Fiscal Year: 2010
    ..with established hypertension abnormally large increases in sympathetic nerve activity, arterial pressure and heart rate often occur in response to exercise which precludes advisement of any strenuous physical activity due to the ..
  68. Amygdala Priming Mechanism Underlying the Panic Response
    SHELLEY THIELEN; Fiscal Year: 2001
    ..maximum of 6 days with a subthreshold dose of the GABAA antagonist bicuculline methiodide exhibit an increase in heart rate (> 50 beats per minute), blood pressure, respiratory rate, and anxiety- like behavior, measured using the ..
  69. Human circadian sensitivity to very short light pulses
    Elizabeth B Klerman; Fiscal Year: 2010
    ..include melatonin suppression (signal for seasonal reproductive changes), pupillary reflexes, and changes in heart rate, performance, and alertness...
  70. Physiological and Emotional Reactivity to Pain after Physical and Sexual Abuse
    KARIN N WESTLUND-HIGH; Fiscal Year: 2011
    ..Coincident physiological response changes in these chronic pain sufferers include decreased heart rate variability (HRV)...
  71. The Effects of Docosahexaenoic acid (DHA) on fetal cardiac outcomes
    Kathleen M Gustafson; Fiscal Year: 2010
    ..has been shown to lower triglycerides and is important to cardiovascular health and autonomic control, lowering heart rate (HR) and blood pressure and increasing heart rate variability (HRV)...
    Michael Lauer; Fiscal Year: 2002
    Although there has been considerable attention paid to the prognostic significance of the heart rate rise during exercise, only recently has it been noted that the heart rate fall after exercise, or "heart-rate recovery," may be an even ..
    PHILIP MC CABE; Fiscal Year: 1990
    The proposed behavioral experiments will explore the CNS pathways involved in the classical conditioning of heart rate responses in rabbits...
  74. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Subcortical arousals associated with changes in breathing, blood pressure, heart rate, and heart rate variability, may be particularly important in infants...
  75. Y Receptor In and Cardiovascular Function From the PHN
    John Martin; Fiscal Year: 2004
    ..by the pancreatic polypeptide neuropeptide Y (NPY) that mediates increases in mean arterial pressure (MAP) and heart rate (HR), and to explore the mechanism by which the related pancreatic polypeptide PYY, which appears to stimulate a ..
    CHARLES GANOTE; Fiscal Year: 2001
    ..of ischemic preconditioning using isolated cardiac myocytes from rabbits, as an example of an animal with a fast heart rate, and from pigs, as an example of an animal with a slow heart rate...
  77. Spiral Electrode Sensor for Intrapartum Fetal Oximetry
    JONAS POLOGE; Fiscal Year: 2003
    Fetal heart rate monitoring is intended to detect signs of fetal distress due to oxygen starvation of the fetus...