pulmonary wedge pressure

Summary

Summary: The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.

Top Publications

  1. doi Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease
    Giuseppe Valerio
    Ospedale Ninetto Melli, Divisione di Pneumologia, 2P Via Lecce 246, San Pietro V co Brindisi, Italy 72027
    Ther Adv Respir Dis 3:15-21. 2009
  2. pmc Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD
    K Vonbank
    Vienna Medical School, Department of Internal Medicine IV, Clinical Division of Pulmonary Medicine, A 1090 Vienna, Austria
    Thorax 58:289-93. 2003
  3. pmc Pulmonary pressures and death in heart failure: a community study
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    J Am Coll Cardiol 59:222-31. 2012
  4. ncbi Pulmonary artery distensibility in pulmonary arterial hypertension: an MRI pilot study
    C Jardim
    Pulmonary Division, Pulmonary Hypertension Unit, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Eur Respir J 29:476-81. 2007
  5. ncbi Global diastolic strain rate for the assessment of left ventricular relaxation and filling pressures
    Jianwen Wang
    Department of Cardiology and Methodist DeBakey Heart Center, The Methodist Hospital, Houston, Tex 77030, USA
    Circulation 115:1376-83. 2007
  6. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
  7. ncbi Can transthoracic Doppler echocardiography predict the discrepancy between left ventricular end-diastolic pressure and mean pulmonary capillary wedge pressure in patients with heart failure?
    Yasuyuki Hadano
    Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Circ J 69:432-8. 2005
  8. ncbi Clinical application of tissue Doppler imaging in patients with idiopathic pulmonary hypertension
    Qinyun Ruan
    Methodist DeBakey Heart Center, The Methodist Hospital, Houston, TX, USA
    Chest 131:395-401. 2007
  9. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
  10. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003

Research Grants

Detail Information

Publications189 found, 100 shown here

  1. doi Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease
    Giuseppe Valerio
    Ospedale Ninetto Melli, Divisione di Pneumologia, 2P Via Lecce 246, San Pietro V co Brindisi, Italy 72027
    Ther Adv Respir Dis 3:15-21. 2009
    ..Among vasoconstrictors, endothelin is claimed to be an important factor. Our aim is to assess the effect of the anti-endothelin drug Bosentan on pulmonary hemodynamics and lung function in patients affected by COPD and PH...
  2. pmc Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD
    K Vonbank
    Vienna Medical School, Department of Internal Medicine IV, Clinical Division of Pulmonary Medicine, A 1090 Vienna, Austria
    Thorax 58:289-93. 2003
    ....
  3. pmc Pulmonary pressures and death in heart failure: a community study
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    J Am Coll Cardiol 59:222-31. 2012
    ....
  4. ncbi Pulmonary artery distensibility in pulmonary arterial hypertension: an MRI pilot study
    C Jardim
    Pulmonary Division, Pulmonary Hypertension Unit, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Eur Respir J 29:476-81. 2007
    ..The present findings suggest that magnetic resonance imaging and pulmonary artery distensibility may be useful noninvasive tools for the evaluation of patients with pulmonary hypertension...
  5. ncbi Global diastolic strain rate for the assessment of left ventricular relaxation and filling pressures
    Jianwen Wang
    Department of Cardiology and Methodist DeBakey Heart Center, The Methodist Hospital, Houston, Tex 77030, USA
    Circulation 115:1376-83. 2007
    ..Mitral early diastolic velocity (E)/SR ratio during the isovolumetric relaxation (IVR) period can be used to estimate LV filling pressures...
  6. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  7. ncbi Can transthoracic Doppler echocardiography predict the discrepancy between left ventricular end-diastolic pressure and mean pulmonary capillary wedge pressure in patients with heart failure?
    Yasuyuki Hadano
    Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Circ J 69:432-8. 2005
    ..However, a discrepancy between LVEDP and mean PCWP is sometimes observed...
  8. ncbi Clinical application of tissue Doppler imaging in patients with idiopathic pulmonary hypertension
    Qinyun Ruan
    Methodist DeBakey Heart Center, The Methodist Hospital, Houston, TX, USA
    Chest 131:395-401. 2007
    ....
  9. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  10. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
  11. ncbi Pulmonary arterial hypertension
    Lewis J Rubin
    University of California, San Diego, School of Medicine, 9300 Campus Point Drive, La Jolla, CA 92037, USA
    Proc Am Thorac Soc 3:111-5. 2006
    ..The article reviews the classification of diseases associated with PAH, the current understanding of its pathogenesis, and the contemporary approach to therapy...
  12. ncbi Pulmonary capillary wedge pressure in mitral stenosis accurately reflects mean left atrial pressure but overestimates transmitral gradient
    D J Hildick-Smith
    Cardiac Unit, Papworth Hospital, Cambridge, United Kingdom
    Am J Cardiol 85:512-5, A11. 2000
    ..2 to +9.8 mm Hg): wedge pressure-assessed transmitral gradient is therefore misleading, routinely overestimating stenosis severity...
  13. ncbi Increased pulmonary venous resistance contributes to increased pulmonary artery diastolic-pulmonary wedge pressure gradient in acute respiratory distress syndrome
    Charles Her
    Department of Anesthesiology, New York Medical College, Valhalla, USA
    Anesthesiology 102:574-80. 2005
    Pulmonary artery diastolic (PAD)-pulmonary wedge pressure (PWP) gradient has been shown to be increased in sepsis and acute respiratory distress syndrome (ARDS)...
  14. ncbi Assessment of intrathoracic blood volume as an indicator of cardiac preload: single transpulmonary thermodilution technique versus assessment of pressure preload parameters derived from a pulmonary artery catheter
    C Wiesenack
    Department of Anaesthesia, University Hospital, Regensburg, Germany
    J Cardiothorac Vasc Anesth 15:584-8. 2001
    ..The assessment of ITBV by the transpulmonary single indicator dilution technique is an interesting alternative to the pressure preload parameters...
  15. ncbi Noninvasive estimation of pulmonary capillary wedge pressure from computed radiography
    J H Woodring
    Department of Diagnostic Radiology, University of Kentucky Medical Center, Lexington 40536 0084, USA
    J Ky Med Assoc 98:115-20. 2000
    ..This study was undertaken to see if computed radiography (CR) could be used to estimate pulmonary capillary wedge pressure (PCWP)...
  16. ncbi Monitoring intravascular volumes for postoperative volume therapy
    H Brock
    General Hospital, Department of Anaesthesia and Intensive Care Medicine, Linz, Austria
    Eur J Anaesthesiol 19:288-94. 2002
    ..The feasibility of monitoring measured intravascular volumes and the cardiac filling pressures were compared to reflect the optimal volume status of postoperative patients...
  17. pmc Tissue Doppler imaging in the estimation of intracardiac filling pressure in decompensated patients with advanced systolic heart failure
    Wilfried Mullens
    Section of Heart Failure and Cardiac Transplantation Medicine, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Circulation 119:62-70. 2009
    ..The objective of this study was to determine the reliability of mitral E/Ea for predicting PCWP in patients admitted for advanced decompensated heart failure...
  18. ncbi Optimal noninvasive assessment of left ventricular filling pressures: a comparison of tissue Doppler echocardiography and B-type natriuretic peptide in patients with pulmonary artery catheters
    Hisham Dokainish
    Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:2432-9. 2004
    ....
  19. ncbi Comparison of a radiofrequency-based wireless pressure sensor to swan-ganz catheter and echocardiography for ambulatory assessment of pulmonary artery pressure in heart failure
    Hugo E Verdejo
    Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Am Coll Cardiol 50:2375-82. 2007
    ..Atlanta, Georgia) pulmonary artery pressure (PAP) monitoring compared with Swan-Ganz (SG) (Hospira, Inc., Lake Forest, Illinois) catheterization and echocardiography (ECHO) in ambulatory HF patients...
  20. ncbi Noninvasive calibration of cardiac pressure transducers in patients with heart failure: an aid to implantable hemodynamic monitoring and therapeutic guidance
    Dougal McClean
    Division of Cardiology, Department of Medicine, and the Research Institute at Cedars Sinai Medical Center, Los Angeles, California, USA
    J Card Fail 12:568-76. 2006
    ..Implantable cardiac pressure monitors require assurance of calibration. This study evaluated if airway pressure responses during Valsalva maneuver (VM) can be used for calibrating intracardiac pressure transducers...
  21. ncbi Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge
    David Osman
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Crit Care Med 35:64-8. 2007
    ..By analyzing a large number of volume challenges, our aim was to test the significance of the recommended target values in terms of prediction of volume responsiveness...
  22. ncbi Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome
    Gustavo A Heresi
    Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Chest Med 27:627-35; abstract ix. 2006
    ..In this article, we review the evidence on the use of the PAC in patients with ALI/ARDS, paying particular attention to the recently published fluid and catheter treatment trial by the ARDS Clinical Trials Network...
  23. ncbi Tissue Doppler imaging estimation of pulmonary artery occlusion pressure in ICU patients
    Alain Combes
    Réanimation Médicale, Institut de Cardiologie, AP HP, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Intensive Care Med 30:75-81. 2004
    ..This study assessed whether the E/E' ratio provides an accurate estimation of pulmonary artery occlusion pressure (PAOP) in mechanically ventilated ICU patients...
  24. ncbi Pulmonary artery wedge pressure and extravascular lung water in patients with acute cardiogenic pulmonary edema requiring mechanical ventilation
    A J Bindels
    Catharina Hospital Eindhoven, Department of Intensive Care, The Netherlands
    Am J Cardiol 84:1158-63. 1999
    ..The pulmonary edema, measured as EVLW index, resolves rapidly when cardiac performance improves, despite positive fluid balances and weight gain in the first 24 hours...
  25. ncbi Assessment of fluid responsiveness in mechanically ventilated cardiac surgical patients
    C Wiesenack
    University Hospital of Regensburg, Department of Anaesthesiology, Regensburg, Germany
    Eur J Anaesthesiol 22:658-65. 2005
    ....
  26. ncbi Evaluation of left ventricular filling pressure by transthoracic Doppler echocardiography in the intensive care unit
    Alain Boussuges
    Service de Reanimation Medicale, CHU Sainte Marguerite, Marseille, France
    Crit Care Med 30:362-7. 2002
    ..To determine whether Doppler transmitral and pulmonary venous flow pattern is related to left ventricular filling pressures in critically ill patients...
  27. ncbi Central venous pressure, pulmonary capillary wedge pressure and intrathoracic blood volumes as preload indicators in cardiac surgery patients
    O Godje
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Eur J Cardiothorac Surg 13:533-9; discussion 539-40. 1998
    ..Measurement of right atria, right ventricular, global end diastolic and intrathoracic blood volume index by arterial thermal dye dilution utilizing the COLD-system may represent an alternative...
  28. pmc Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study
    Philippe Vignon
    Medical Surgical Intensive Care Unit, Dupuytren Teaching Hospital, 2 Ave, Martin Luther King, 87000 Limoges, France
    Crit Care 12:R18. 2008
    ..Accordingly, we prospectively assessed the ability of transoesophageal echocardiography (TEE) Doppler to predict an invasive pulmonary artery occlusion pressure (PAOP) < or = 18 mmHg in ventilated patients...
  29. ncbi Doppler estimation of left ventricular filling pressures in patients with mitral valve disease
    Abhinav Diwan
    Section of Cardiology, University of Cincinnati, Cincinnati, Ohio, USA
    Circulation 111:3281-9. 2005
    ..We therefore undertook this study to test its usefulness in a patient population...
  30. ncbi Transesophageal Pulsed Doppler echocardiography of pulmonary venous flow to assess left ventricular filling pressure in ventilated patients with acute respiratory distress syndrome
    Frederic Vargas
    Département de Réanimation Médicale, Hopital Pellegrin, Bordeaux Cedex, France
    J Crit Care 19:187-97. 2004
    ..To determine whether the systolic fraction (SF) of the pulmonary venous flow (PVF), measured by transesophageal echocardiography (TEE) could be used to estimate the pulmonary artery occlusion pressure (PAOP)...
  31. ncbi Relationship of carbon dioxide tension in arterial blood to pulmonary wedge pressure in heart failure
    G Lorenzi-Filho
    Dept of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Ontario, Canada
    Eur Respir J 19:37-40. 2002
    ..These findings imply that hypocapnia in patients with chronic stable congestive heart failure is a respiratory manifestation of elevated left ventricular filling pressures...
  32. ncbi Echocardiographic Doppler assessment of pulmonary capillary wedge pressure in surgical patients with postoperative circulatory shock and acute lung injury
    Belaid Bouhemad
    Reanimation Chirurgicale Pierre Viars, Department of Anesthesiology, Hospital Pitié Salpêtrière, University of Paris VI, Paris, France
    Anesthesiology 98:1091-100. 2003
    ..The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients...
  33. ncbi Assessment of cardiac preload and left ventricular function under increasing levels of positive end-expiratory pressure
    Thomas Luecke
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University Hospital of Mannheim, Mannheim, Germany
    Intensive Care Med 30:119-26. 2004
    ..The validity of these parameters was tested by means of correlation with left ventricular end-diastolic volume (LVEDV), the true cardiac preload...
  34. doi Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD
    Sebastiaan Holverda
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Pulm Pharmacol Ther 21:558-64. 2008
    ....
  35. ncbi The use of transesophageal echocardiography for preload assessment in critically ill patients
    C P Tousignant
    Department of Anaesthesia, St Michael s Hospital, University of Toronto, Toronoto, Ontario, Canada
    Anesth Analg 90:351-5. 2000
    ..Few ICU patients and only those with a small EDA responded to volume administration. It was not possible to identify an overall optimal LV EDA below which most patients demonstrate volume-recruitable increases in SV...
  36. ncbi Regional right ventricular dysfunction in chronic pulmonary hypertension
    Virginija Dambrauskaite
    Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium
    J Am Soc Echocardiogr 20:1172-80. 2007
    ..Therefore, there is an increasing interest for the assessment of RV function. This study aimed to evaluate the regional RV function in patients with PH by using ultrasonic strain rate imaging...
  37. ncbi Noninvasive assessment of hemodynamic subsets in patients with acute myocardial infarction using digital color Doppler velocity profile integration and pulmonary venous flow analysis
    T Hozumi
    Division of Cardiology, Kobe General Hospital, Japan
    Am J Cardiol 83:1027-32. 1999
    ..Thus, ACOM and PV flow analysis by color Doppler echocardiography is useful in the noninvasive assessment of hemodynamic subsets in patients with AMI...
  38. ncbi Sympathetic stimulation using the cold pressor test increases coronary collateral flow
    S F de Marchi
    Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Swiss Med Wkly 131:351-6. 2001
    ..The collateral-flow-increasing effect of CPT is comparable to the recruitment effect of the occlusion itself. This may reflect a coronary collateral vasodilation mediated by the sympathetic nervous system...
  39. ncbi Pulmonary capillary pressure measurement from pulmonary artery occlusion pressure decay profile analysis in sheep
    G E Wakerlin
    Department of Anesthesia, Stanford University School of Medicine, CA 94305, USA
    Anesth Analg 81:17-23. 1995
    ..These results suggest that Ppao decay profile analysis as currently performed has limited application...
  40. ncbi Capillary pressure estimates from arterial and venous occlusion in intact dog lung
    M Corboz
    Laboratoire de Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculte de Medecine de Grenoble, Universite Joseph Fourier, La Tronche, France
    Eur Respir J 8:1122-9. 1995
    ..As the middle fractional pressure gradient is low, we conclude that pulmonary capillary pressure estimates from arterial occlusion are close to the venous occlusion estimates of capillary pressure in the intact dog lung...
  41. ncbi Pulmonary capillary pressures during the acute respiratory distress syndrome
    Silvia Nunes
    Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland
    Intensive Care Med 29:2174-9. 2003
    ..to assess Pcap under different levels of positive end-expiratory pressure (PEEP) and (3). to compare the visual method and a mathematical model to determine Pcap...
  42. ncbi Single arterial occlusion to locate resistance in patients with pulmonary hypertension
    P Fesler
    Dept of Physiology, Erasme University Hospital Brussels, Brussels, Belgium
    Eur Respir J 21:31-6. 2003
    ..The occlusion technique may help to locate the predominant site of increased resistance in patients with severe pulmonary hypertension, but does not allow for a satisfactory differential diagnosis on an individual basis...
  43. ncbi Hemodynamics during humoral rejection events with total versus standard orthotopic heart transplantation
    Ivan Aleksic
    Department of Thoracic and Cardiovascular Surgery, University Essen, Essen, Germany
    Ann Thorac Cardiovasc Surg 10:285-9. 2004
    ..We hypothesized that total orthotopic heart transplantation (TOHT) improves humoral rejection hemodynamics compared with biatrial transplantation or standard orthotopic heart transplantation (SOHT)...
  44. ncbi Reduced pulmonary clearance of endothelin in congestive heart failure: a marker of secondary pulmonary hypertension
    Cezar Staniloae
    Department of Medicine, Montreal Heart Institute, Quebec, Canada
    J Card Fail 10:427-32. 2004
    ..Endothelin-1 (ET-1) levels are elevated in congestive heart failure (CHF) in relation with the severity of pulmonary hypertension. We evaluated whether a reduced pulmonary ET-1 clearance could contribute to this elevation...
  45. ncbi Current perspectives modern hemodynamic evaluation of the pulmonary circulation. Application to pulmonary arterial hypertension and embolic pulmonary hypertension
    Robert Naeije
    Department of Pathophysiology, Faculty of Medicine of the Free University of Brussels, Brussels, Belgium
    Ital Heart J 6:784-8. 2005
    ..The optimal value of this ratio is depressed in minimally symptomatic pulmonary arterial hypertension patients, indicating pending right heart failure...
  46. pmc Pulmonary capillary pressure in pulmonary hypertension
    Rogerio Souza
    Pulmonary Division, Respiratory ICU Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Crit Care 9:R132-8. 2005
    ....
  47. ncbi Measurement of total pulmonary arterial compliance using invasive pressure monitoring and MR flow quantification during MR-guided cardiac catheterization
    Vivek Muthurangu
    Cardiac MR Research Group, Division of Imaging Sciences, King s College London, UK
    Am J Physiol Heart Circ Physiol 289:H1301-6. 2005
    ..89, P < 0.001) and between compliance and mean pulmonary arterial pressure (r = 0.72, P < 0.001). We have demonstrated the feasibility of quantifying total arterial compliance using an MR method...
  48. ncbi Pulmonary venous flow in pure mitral stenosis and sinus rhythm--does pulmonary hypertension alter pulmonary venous flow velocity?
    Jong Won Ha
    Cardiology Division, Yonsei Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul, Korea
    Echocardiography 20:129-35. 2003
    ..There was no significant correlation between PVFAr and MVA. LA size and LAP. In conclusion, in patients with pure MS and sinus rhythm, PVF, especially PVFAr, is influenced by the presence of pulmonary hypertension...
  49. ncbi Reversal of pulmonary hypertension and subsequent repair of atrial septal defect after treatment with continuous intravenous epoprostenol
    Adaani E Frost
    Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    J Heart Lung Transplant 24:501-3. 2005
    ..Judicious use of continuous prostacyclin in apparently inoperable patients with congenital heart disease may be associated with significant reversal of pulmonary hypertension, and conversion to an operable state...
  50. ncbi Noncultured cell transplantation in an ovine model of right ventricular preparation
    Nicolas Borenstein
    IMM Recherche, Center for Experimentation and Applied Research, 42 Boulevard Jourdan, 75014 Paris, France
    J Thorac Cardiovasc Surg 129:1119-27. 2005
    ..The aim of this study was to explore whether myogenic cell transplantation could contribute to right ventricular function during pulmonary artery constriction in an ovine model...
  51. ncbi Mechanical ventricular support lowers pulmonary vascular resistance in a patient with congential heart disease
    Jason A Petrofski
    Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27703, USA
    Ann Thorac Surg 75:1005-7. 2003
    ..The patient underwent placement of biventricular assist devices and subsequently experienced marked reduction of PVR, ultimately enabling successful heart transplantation...
  52. ncbi Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale
    Martha S Kingman
    Pulmonary Hypertension Group, Pulmonary Hypertension Clinic, Cardiovascular Institute, St Paul University Hospital, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Prog Cardiovasc Nurs 20:168-72. 2005
    ..A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004...
  53. ncbi Acute volume reduction with aortic valve replacement immediately improves ventricular mechanics in patients with aortic regurgitation
    Shigeki Morita
    Department of Cardiovascular Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Thorac Cardiovasc Surg 125:283-9. 2003
    ..Few data have been available regarding the immediate response in ventricular mechanics to acute volume reduction caused by aortic valve replacement for aortic regurgitation...
  54. ncbi The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access
    Farid Nakhoul
    Department of Nephrology, Rambam Medical Center, Haifa 31096, Israel
    Nephrol Dial Transplant 20:1686-92. 2005
    ..This study evaluated the possibility that PHT in these patients is triggered or aggravated by chronic HD via surgical A-V access, and the role of endothelin-1 (ET-1) and nitric oxide (NO) in this syndrome...
  55. ncbi Intraosseous hypertonic saline solution for resuscitation of uncontrolled, exsanguinating liver injury in young Swine
    R M Carrera
    Pediatric Surgery Division, Santa Casa São Paulo, Faculty of Medical Sciences, Sao Paulo, Brazil
    Eur Surg Res 36:282-92. 2004
    ..It was concluded that the hypertonic saline solution in this experimental model did not promote hemodynamic improvement and there were no differences between the two sites of fluid resuscitation regarding intra-abdominal blood loss...
  56. ncbi Simplified pulmonary vasodilatory testing in the cardiac catheterization laboratory with nasal cannula nitric oxide
    M Scheurer
    Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Pediatr Cardiol 27:84-6. 2006
    ..1-2.6) (p = 0.002). No adverse side effects were noted. We found this NO delivery system to be a simple and effective method of pulmonary vasodilatory testing that may have wide applicability in the cardiac catheterization laboratory...
  57. ncbi Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
    H A Ghofrani
    Dept of Internal Medicine, University Hospital, Justus Liebig University Giessen, Giessen, Germany
    Eur Respir J 23:321-6. 2004
    ..Future studies are warranted to confirm the encouraging long-term beneficial results observed in the present limited number of patients...
  58. ncbi Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults
    Francesco Santini
    Division of Cardiac Surgery and Anesthesiology, University of Verona, OCM Borgo Trento, Piazzale Stefani 1, 37126, Verona, Italy
    Int J Cardiol 103:156-63. 2005
    ....
  59. ncbi Effects of intravenous nesiritide on pulmonary vascular hemodynamics in pulmonary hypertension
    Andrew D Michaels
    Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, 94143, USA
    J Card Fail 11:425-31. 2005
    ..Nesiritide is effective in the treatment of decompensated heart failure (HF). We evaluated the acute hemodynamic effects of nesiritide, a recombinant B-type natriuretic peptide, in patients with HF and pulmonary hypertension (PH)...
  60. ncbi Right heart haemodynamic values and respiratory function test parameters in chronic smokers
    M Gulbaran
    Institute of Cardiology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
    East Mediterr Health J 10:90-5. 2004
    ..Early diagnosis and therapy of chronic obstructive pulmonary disease in smokers may be possible without using invasive methods...
  61. ncbi [Levosimendan-long-term inodilation in an infant with myocardial infarction]
    Y C Luther
    Abteilung für Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Z Kardiol 93:234-9. 2004
    ..This case may suggest the use of Levosimendan as a long-term inotropic agent and pulmonary vasodilator in children with depressed cardiac function...
  62. ncbi Regression of postobstructive vasculopathy after revascularization of chronically obstructed pulmonary artery
    Elie Fadel
    Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Universite Paris Sud, France
    J Thorac Cardiovasc Surg 127:1009-17. 2004
    ..We hypothesized that postobstructive pulmonary vasculopathy may regress after reperfusion in a piglet model of chronic (5 weeks) left pulmonary artery obstruction...
  63. ncbi Functional changes of the heart and lung in perioperative period of orthotopic liver transplantation
    Shu Sen Zheng
    Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
    Hepatobiliary Pancreat Dis Int 1:335-9. 2002
    ..To investigate the variation of functions of the heart and lung during orthotopic liver transplantation (OLT)...
  64. ncbi Effects of norepinephrine and dobutamine on pressure load-induced right ventricular failure
    Francois Kerbaul
    Laboratory of Physiology, Free University of Brussels, Belgium
    Crit Care Med 32:1035-40. 2004
    ..A transient increase in pulmonary arterial (PA) pressure can persistently depress right ventricular (RV) contractility. We investigated the effects norepinephrine and dobutamine on RV-PA coupling in this model of RV failure...
  65. ncbi Site of coronary sinus drainage does not significantly affect coronary flow reserve in patients long term after Fontan operation
    A Eicken
    Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum, Technische Universitat Munchen, Lazarettstrasse 36, D 80636 Munich, Germany
    Pediatr Cardiol 27:102-9. 2006
    ..The positive correlation between CFR and pulmonary resistance demands further evaluation...
  66. ncbi Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    Elizabeth S Klings
    N Engl J Med 350:2521-2; author reply 2521-2. 2004
  67. ncbi Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs
    Wei Chen Kuo
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Am J Vet Res 65:931-7. 2004
    ..1 mg of hydromorphone/kg), and medetomidine-butorphanol (20 microg of medetomidine/kg and 0.2 mg of butorphanol tartrate/kg) in dogs...
  68. ncbi Human B-natriuretic peptide improves hemodynamics and renal function in heart transplant patients immediately after surgery
    David S Feldman
    Division of Cardiology Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    J Card Fail 10:292-6. 2004
    ..B-natriuretic peptide (BNP) is effective in the treatment of decompensated heart failure, but has not specifically been evaluated in the immediate postoperative cardiac transplant population...
  69. ncbi Pulmonary arterial hypertension in previously splenectomized patients with beta-thalassemic disorders
    Vichai Atichartakarn
    Division of Hematology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Int J Hematol 78:139-45. 2003
    ..PHT was not due to pulmonary emboli. Our findings suggested that severe PHT was due to increased PVRI from thrombotic pulmonary arteriopathy, likely from chronic low-grade hypercoagulability and platelet activation after splenectomy...
  70. ncbi Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates
    Armin Sablotzki
    Clinic of Anesthesiology and Intensive Care Medicine, Martin Luther University of Halle Wittenberg, Halle, Germany
    Can J Anaesth 52:1076-82. 2005
    ..A pilot study was under-taken to test the hypothesis that inhaled aerosolized milrinone may cause selective pulmonary vasodilation...
  71. ncbi Continuous recording of pulmonary artery diastolic pressure and cardiac output using a novel ultrasound transducer
    P Anthony N Chandraratna
    Division of Cardiology, Los Angeles County, California, USA
    J Am Soc Echocardiogr 15:1381-6. 2002
    ..The CO, PADP, and pulmonary wedge pressure were recorded from the PA catheter immediately after the ultrasound studies...
  72. ncbi [The value of recording the pulmonary insufficiency flow by continuous Doppler for the evaluation of systolic pulmonary artery pressure]
    H Raffoul
    , , Paris
    Arch Mal Coeur Vaiss 83:1703-9. 1990
    ..The calculation by the two methods using tricuspid and pulmonary regurgitant jets increases the reliability of the results and provides a means of internal validation of the Doppler technique...
  73. ncbi Cardiovascular effects of romifidine in dogs
    B H Pypendop
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, University of Liege, Belgium
    Am J Vet Res 62:490-5. 2001
    ....
  74. ncbi Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension
    T Gessler
    Dept of Internal Medicine, Justus-Liebig-University of Giessen, Germany
    Eur Respir J 17:14-9. 2001
    ....
  75. ncbi Chronic sildenafil lowers transpulmonary gradient and improves cardiac output allowing successful heart transplantation
    Andrew Jabbour
    Heart Transplant Unit, St Vincent s Hospital, Sydney, New South Wales, Australia
    Eur J Heart Fail 9:674-7. 2007
    ..This study aimed to assess the effects of chronic sildenafil administration on the PVR, transpulmonary gradient (TPG), and cardiac output (CO) in patients with heart failure awaiting heart transplantation...
  76. ncbi Right ventricular failure in patients with preserved ejection fraction and diastolic dysfunction: an underrecognized clinical entity
    Ramzan M Zakir
    Department of Medicine, Hackensack University Medical Center, Affiliate of University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Hackensack, NJ, USA
    Congest Heart Fail 13:164-9. 2007
    ..The authors review the pathophysiology, clinical presentation, and suggested treatment of this underrecognized clinical entity...
  77. ncbi Noninvasive assessment of pulmonary vascular resistance using Doppler tissue imaging of the tricuspid annulus
    Swaminatha V Gurudevan
    Division of Cardiology, University of California Irvine School of Medicine, Irvine, USA
    J Am Soc Echocardiogr 20:1167-71. 2007
    ..We undertook this study to determine whether Doppler tissue imaging of the tricuspid annulus could be used to assess PAP and PVR noninvasively...
  78. ncbi Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous IV epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels
    Kelly M Chin
    Department of Internal Medicine, University of Texas Southwestern Pulmonary Hypertension Program, 5909 Harry Hines Blvd, Dallas, TX 75235 9254, USA
    Chest 132:786-92. 2007
    ....
  79. ncbi Modification of the arterial anastomotic technique improves survival in porcine single lung transplant model
    C Van De Wauwer
    Laboratory for Experimental Thoracic Surgery, KU Leuven, Belgium
    Acta Chir Belg 106:450-7. 2006
    ..We developed an unilateral porcine lung transplant model to study IRI and describe our experience with two different arterial anastomotic techniques...
  80. ncbi Assessment of pulmonary vascular resistance by Doppler echocardiography in patients with pulmonary arterial hypertension
    Nedim Selimovic
    Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    J Heart Lung Transplant 26:927-34. 2007
    ..The aim of the present study was to investigate whether Doppler echocardiography can be used to determine PVR in patients with PAH...
  81. ncbi Transpulmonary pressure gradient verifies pulmonary hypertension is initiated by increased arterial resistance in broilers
    A G Lorenzoni
    Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
    Poult Sci 87:125-32. 2008
    ....
  82. ncbi Inheritance of pulmonary arterial pressure in Angus cattle and its correlation with growth
    K L Shirley
    Department of Animal Sciences, Colorado State University, Fort Collins 80523, USA
    J Anim Sci 86:815-9. 2008
    ..Selection for growth at low altitude will produce cattle less suited to high altitude...
  83. pmc Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease
    Peter M Mourani
    Division of Critical Care, Children s Hospital and University of Colorado Denver School of Medicine, Denver, Colorado 80045, USA
    Pediatrics 121:317-25. 2008
    ..The goal was to determine the clinical utility of Doppler echocardiography in predicting the presence and severity of pulmonary hypertension in patients with chronic lung disease who subsequently underwent cardiac catheterization...
  84. doi Estimation of mean pulmonary artery pressure: simpler than expected
    Denis Chemla
    Chest 133:592-3. 2008
  85. ncbi Estimation of pulmonary vascular resistance with Doppler diastolic gradients
    Mehnaz Atiq
    Department of Pediatrics Cardiology, The Aga Khan University Hospital, PO Box 3500, Karachi 74800, Pakistan
    Asian Cardiovasc Thorac Ann 16:221-5. 2008
    ....
  86. ncbi Pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension
    Pierre Tourneux
    Clinique de Médecine Néonatale, Hopital Jeanne de Flandre, CHRU de Lille, Lille, France
    J Pediatr 153:345-9. 2008
    ..To evaluate the respiratory and the pulmonary circulatory effects of norepinephrine in newborn infants with persistent pulmonary hypertension (PPHN)-induced cardiac dysfunction...
  87. ncbi [Limitations of the feasibility of right catheterization in the evaluation for cardiac transplantation]
    G Dreyfus
    , , Paris
    Arch Mal Coeur Vaiss 82:903-9. 1989
    ..By using the dobutamine test we were able to reduce considerably the mortality due to pulmonary arterial hypertension and also to exclude orthotopic transplantation in some patients...
  88. ncbi Long-term hemodynamic benefit of biventricular pacing depending on coronary sinus lead position
    H Nägele
    Gustav Adolf Stift, 21465 Reinbek, Germany
    Herzschrittmacherther Elektrophysiol 17:185-90. 2006
    ..Acute studies in cardiac resynchronization therapy (CRT) showed that hemodynamic effects may depend on the coronary sinus (CS) lead position. However, there are no data on the longterm effect of CS lead position...
  89. pmc Effects of acute changes in pulmonary wedge pressure on periodic breathing at rest in heart failure patients
    Thomas P Olson
    Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Am Heart J 153:104.e1-7. 2007
    ..Although the mechanism(s) contributing to PB remain unclear, we examined whether changes in pulmonary wedge pressure (PWP) and pulmonary vascular resistance (PVR) alter PB in patients with established HF.
  90. ncbi Thoracic epidural anesthesia impairs the hemodynamic response to acute pulmonary hypertension by deteriorating right ventricular-pulmonary arterial coupling
    Steffen Rex
    Laboratory for Experimental Anesthesiology, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 35:222-9. 2007
    ..In the present study, we tested the hypothesis that thoracic epidural anesthesia decreases right ventricular contractility and limits its capacity to tolerate pulmonary hypertension...
  91. ncbi [Pulmonary hypertension in pediatric heart surgery]
    N Falcone
    , , Hospital 12 de Octubre, Madrid, Spain
    Rev Esp Anestesiol Reanim 48:462-4. 2001
    ....
  92. ncbi Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival
    Oswaldo Castro
    Center for Sickle Cell Disease and Division of Cardiology, Department of Medicine, Howard University College of Medicine, Washington, DC 20059, USA
    Blood 101:1257-61. 2003
    ..044, Breslow-Gehan log-rank test). Our findings suggest that PHTN in patients with SCD shortened their survival...
  93. ncbi Renal anemia and its hemodynamic response--findings invasively determined over a period of 20 years
    G E Schäfer
    Medical Hospital III, Clinic Offenbach am Main, Germany
    Clin Nephrol 58:S52-7. 2002
    ..The hypercirculation did not cause an increase of the pulmonary arterial and pulmonary wedge pressure. Particularly in the case of already existing myocardial damage and coronary arteriosclerosis the ..
  94. ncbi Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease
    P Goyal
    Department of Cardiac Anaesthesiology, Cardio Thoracic Centre, All India Institute of Medical Sciences, New Delhi 110029, India
    Br J Anaesth 97:208-14. 2006
    ..We investigated the acute effects of inhaled nitroglycerin on pulmonary and systemic haemodynamics in children with PAH associated with congenital heart disease...
  95. ncbi Pulmonary vascular changes induced by unilateral pulmonary venous obstruction
    M Endo
    Department of Cardiovascular Surgery, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Pediatr Cardiol 23:420-5. 2002
    ..49, p=0.04). This finding suggests that the pathogenesis of PAWP-related medial thickening of the bilateral lung pulmonary artery begins with the sensing by the bilateral lung of PV pressure buildup in the unilateral lung...
  96. ncbi Nesiritide acutely increases pulmonary and systemic levels of nitric oxide in patients with pulmonary hypertension
    Kiran K Khush
    Division of Cardiology, University of California at San Francisco Medical Center, San Francisco, California, USA
    J Card Fail 12:507-13. 2006
    ..This study investigated mechanisms by which the vasodilator B-type natriuretic peptide (BNP) affects the systemic and pulmonary vasculature in PH patients...
  97. ncbi Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide
    Evangelos Michelakis
    Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Canada
    Circulation 105:2398-403. 2002
    ..We hypothesized that oral sildenafil, a phosphodiesterase-5 inhibitor, is a safe and effective alternative to iNO...
  98. ncbi Noninvasive estimation of both systolic and diastolic pulmonary artery pressure from Doppler analysis of tricuspid regurgitant velocity spectrum in patients with chronic heart failure
    Luca Lanzarini
    Department of Cardiology, IRCCS Policlinico S Matteo, Pavia, Italy
    Am Heart J 144:1087-94. 2002
    ..We sought to verify the accuracy of this method in a large population of patients with heart failure...
  99. ncbi Epoprostenol-induced pulmonary vasodilatation in patients with pulmonary hypertension measured by electrical impedance tomography
    H J Smit
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Physiol Meas 23:237-43. 2002
    ..From these results we conclude that EIT is a reliable method to measure blood volume changes due to pharmacologically induced vasodilatation in the pulmonary bed...
  100. ncbi Tissue Doppler assessment of longitudinal right and left ventricular strain and strain rate in pulmonary artery hypertension
    Sanjay Rajdev
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama, 35249, USA
    Echocardiography 23:872-9. 2006
    ..This reduction in left ventricular function was noted in patients with both normal and reduced right ventricular systolic functions by two-dimensional echocardiography...
  101. ncbi [Mid-term outcome of acute right ventricular dysfunction in biventricular myocardial infarction. Hemodynamic and cineangiographic studies]
    C Descaves
    Service de cardiologie A, , Rennes
    Arch Mal Coeur Vaiss 80:1268-77. 1987
    ..e. RV end-diastolic pressure/RV systolic pressure ratio (p less than 0.001) and right atrial pressure/pulmonary wedge pressure ratio (p less than 0...

Research Grants72

  1. LUNG VASCULAR EFFECTS OF HIGH FREQUENCY VENTILATION
    MUKUL BANERJEE; Fiscal Year: 1990
    ..parameters to be recorded in this project include systemic and pulmonary arterial blood pressures, pulmonary wedge pressure, left atrial pressure, heart rate, cardiac output, arterial blood gases, including pH, concentrations of ..
  2. BEHAVIORAL PHARMACOLOGY OF ABUSED AEROSOLS - 'CRACK'
    Ronald Wood; Fiscal Year: 1992
    ..6) demonstration of the feasibility of applying these techniques to methamphetamine HCI smoking...
  3. BEHAVIORAL PHARMACOLOGY OF ABUSED AEROSOLS - 'CRACK'
    Ronald Wood; Fiscal Year: 1991
    ..6) demonstration of the feasibility of applying these techniques to methamphetamine HCI smoking...
  4. Human Cardiorenal Syndrome
    Horng H Chen; Fiscal Year: 2010
    ..This research should aid in addressing this health challenge. ..
  5. Human Cardiorenal Syndrome
    Horng Chen; Fiscal Year: 2009
    ..This research should aid in addressing this health challenge. ..
  6. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  7. Vascular Dysfunction with Increased Pulmonary Blood Flow: A role for PPAR Gamma
    Peter Oishi; Fiscal Year: 2008
    ..Understanding the controlling mechanisms of this pathology might lead to novel and effective prevention and treatment strategies that will improve the survival and quality of life of this vulnerable population. (End of Abstract) ..
  8. Vascular Dysfunction with Increased Pulmonary Blood Flow: A role for PPAR Gamma
    Peter Oishi; Fiscal Year: 2007
    ..Understanding the controlling mechanisms of this pathology might lead to novel and effective prevention and treatment strategies that will improve the survival and quality of life of this vulnerable population. (End of Abstract) ..
  9. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2007
    ..3) Augmenting expression of O2-sensitive, DASMC Kv channels in preterm or ionically remodeled DA (using an SMC-specific adenovirus) will enhance 02 constriction. ..
  10. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2005
    ..3) Augmenting expression of O2-sensitive, DASMC Kv channels in preterm or ionically remodeled DA (using an SMC-specific adenovirus) will enhance 02 constriction. ..
  11. Attenuating Inflammation via Protein-Calorie Restriction
    Todd Rice; Fiscal Year: 2007
    ....
  12. Pathogenetic Mechanisms of Brochopulmonary Dysplasia
    PETER MOURANI; Fiscal Year: 2007
    ..D. in the University of Colorado's Clinical Science Program. In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..
  13. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2007
    ..abstract_text> ..
  14. Novel Strategies Targeting Acute Exacerbation of COPD
    Richard Albert; Fiscal Year: 2007
    ..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
  15. Autologous Cellular Therapy for Ventricular Dysfunction
    Robert Kormos; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Autologous Cellular Therapy for Ventricular Dysfunction
    Robert Kormos; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2005
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  18. EFFECTS OF STATINS ON PULMONARY HYPERTENSION
    Reda Girgis; Fiscal Year: 2007
    ..This award will allow the candidate to develop into a well-trained independent researcher in PH. ..
  19. UCLA IPF Clinical Research Network
    David Zisman; Fiscal Year: 2007
    ..Secondary efficacy endpoints include gas exchange and quality of life (QOL). We anticipate an improvement in 6MWD in patients who receive sildenafil compared to those who receive placebo. (End of Abstract) ..
  20. Cardiopulmonary Exercise Testing: Pulmonary Hypertension
    Ronald Oudiz; Fiscal Year: 2007
    .._l.Center. PHS 398/2590(Rev.05/01) Page _, LJ ContinuationFormatPage NumberpagesconsecutivelyatthebottomthroughoutheapplicationD. o no_u_stesuffixesuchas3a, 3b. ..
  21. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2007
    ..abstract_text> ..
  22. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2008
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  23. Natriuretic Peptides in Pulmonary Endothelial Cell Barrier Function
    James Klinger; Fiscal Year: 2009
    ..Findings from these studies will further our understanding of cellular mechanism that modulate pulmonary edema formation and determine if the NPs and their receptors are potential therapeutic targets for acute lung injury. ..
  24. Natriuretic Peptides in Pulmonary Endothelial Cell Barrier Function
    JAMES RAYMOND KLINGER; Fiscal Year: 2010
    ..Findings from these studies will further our understanding of cellular mechanism that modulate pulmonary edema formation and determine if the NPs and their receptors are potential therapeutic targets for acute lung injury. ..
  25. Exhaled Nitric Oxide and Oxidative Stress in Pulmonary Arterial Hypertention Asso
    Reda E Girgis; Fiscal Year: 2010
    ..This study aims to develop and validate novel, easily-obtained biomarkers in exhaled breath and urine that may ultimately improve clinical management of these patients and allow early detection of disease. (End of Abstract) ..
  26. Exhaled Nitric Oxide and Oxidative Stress in Pulmonary Arterial Hypertention Asso
    Reda Girgis; Fiscal Year: 2009
    ..This study aims to develop and validate novel, easily-obtained biomarkers in exhaled breath and urine that may ultimately improve clinical management of these patients and allow early detection of disease. (End of Abstract) ..
  27. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  28. Building Interdisciplinary Research Careers in Women's Health
    Judith Regensteiner; Fiscal Year: 2008
    ..The UCDHSC BIRCWH Program will play a leading role in the development of a successful cadre of strong, independent investigators whose goal through their research, is to improve the health of women. ..
  29. Pathogenetic Mechanisms of Brochopulmonary Dysplasia
    PETER MOURANI; Fiscal Year: 2008
    ..D. in the University of Colorado's Clinical Science Program. In addition, he will actively participate and train in the Pediatric GCRC, and frequently interact with his sponsor, mentors, and collaborators. ..
  30. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  31. Attenuating Inflammation via Protein-Calorie Restriction
    Todd Rice; Fiscal Year: 2008
    ....
  32. UCLA IPF Clinical Research Network
    David Zisman; Fiscal Year: 2008
    ..Secondary efficacy endpoints include gas exchange and quality of life (QOL). We anticipate an improvement in 6MWD in patients who receive sildenafil compared to those who receive placebo. (End of Abstract) ..
  33. Natriuretic Peptides in Pulmonary Endothelial Cell Barrier Function
    James Klinger; Fiscal Year: 2008
    ..Findings from these studies will further our understanding of cellular mechanism that modulate pulmonary edema formation and determine if the NPs and their receptors are potential therapeutic targets for acute lung injury. ..
  34. Research Priorities in Ambulatory Management of Obstructive Sleep Apnea Workshop
    SAMUEL KUNA; Fiscal Year: 2007
    ..We submit that this workshop is an essential ?next step? to ensuring that there is[unreadable] substantive advancement of scientific knowledge in this important field. ..
  35. COPD Clinical Research Network & Clinical Research Skills Core Development
    Gerard Criner; Fiscal Year: 2007
    ..abstract_text> ..
  36. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2006
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  37. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2006
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. [unreadable] [unreadable]..
  38. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 1999
    ....
  39. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 1999
    ..This close correlation in responses will allow an exploration in animal experiments of the possible mechanisms underlying observations made in humans. ..
  40. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2003
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  41. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2003
    ....
  42. EXERCISE/TRAINING IN CHILDREN WITH HEART DISEASE
    Ruey Kang Chang; Fiscal Year: 2003
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  43. Cardiopulmonary Exercise Testing: Pulmonary Hypertension
    Ronald Oudiz; Fiscal Year: 2003
    ....
  44. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2002
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  45. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2002
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  46. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2002
    ....
  47. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2001
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  48. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSLCES
    SAMUEL KUNA; Fiscal Year: 2001
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  49. Novel Strategies Targeting Acute Exacerbation of COPD
    Richard Albert; Fiscal Year: 2003
    ..This information will, at the same time, also provide information regarding the pathobiology of COPD exacerbations. ..
  50. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2000
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  51. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2004
    ..abstract_text> ..
  52. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2006
    ..abstract_text> ..
  53. Role of VEGF in Neonatal Pulmonary Hypertension
    Theresa Grover; Fiscal Year: 2007
    ..These studies will provide an integrated approach to the hypothesis, incorporating whole animal physiology coupled with molecular and cellular studies. ..
  54. ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE
    William Abraham; Fiscal Year: 2005
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  55. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  56. UCLA IPF Clinical Research Network
    David Zisman; Fiscal Year: 2005
    ..Secondary efficacy endpoints include gas exchange and quality of life (QOL). We anticipate an improvement in 6MWD in patients who receive sildenafil compared to those who receive placebo. (End of Abstract) ..
  57. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2000
    ....
  58. RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSCLES
    SAMUEL KUNA; Fiscal Year: 2000
    ..This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania. ..
  59. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2005
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  60. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004
    ..abstract_text> ..
  61. EXERCISE/TRAINING IN CHILDREN WITH HEART DISEASE
    Ruey Kang Chang; Fiscal Year: 2002
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  62. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2001
    ....
  63. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2003
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  64. COPD Clinical Research Network & Clinical Research Skil*
    Gerard Criner; Fiscal Year: 2004
    ..abstract_text> ..
  65. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2005
    ..abstract_text> ..
  66. Cardiopulmonary Exercise Testing: Pulmonary Hypertension
    Ronald Oudiz; Fiscal Year: 2006
    ..abstract_text> ..
  67. Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures
    SCOTT DAVID HALPERN; Fiscal Year: 2010
    ..This work will both clarify mechanisms by which incentives alter behaviors, and will identify better ways to reduce smoking and other important causes of preventable death. ..