Genomes and Genes
Summary: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Publications255 found, 100 shown here
- Role of blood pressure reduction in prevention of cardiac and vascular hypertrophyHiroshi Yokoyama
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
Am J Hypertens 18:922-9. 2005..of cardiac and vascular remodeling associated with inhibition of angiotensin II is independent of the blood pressure (BP)-lowering action of angiotensin II type 1 (AT1) receptor blockade...
- Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureAram V Chobanian
Boston University School of Medicine, Boston, Mass, USA
Hypertension 42:1206-52. 2003The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure...
- The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportAram V Chobanian
Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
JAMA 289:2560-72. 2003..Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" provides a new guideline for hypertension prevention and management...
- Prediction of coronary heart disease using risk factor categoriesP W Wilson
Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
Circulation 97:1837-47. 1998The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate ..
- Expert consensus document on arterial stiffness: methodological issues and clinical applicationsStephane Laurent
Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
Eur Heart J 27:2588-605. 2006....
- 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)Giuseppe Mancia
Clinica Medica, Ospedale San Gerardo, , Via Pergolesi, 33 - 20052 MONZA (Milano, Italy
J Hypertens 25:1105-87. 2007
- Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research GroupF M Sacks
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
N Engl J Med 344:3-10. 2001The effect of dietary composition on blood pressure is a subject of public health importance...
- A genome-wide association study of hypertension and blood pressure in African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
PLoS Genet 5:e1000564. 2009..We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the ..
- 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial HypertensionGiuseppe Mancia
University of Milano-Bicocca, Ospedale San Gerardo, Milan, Italy
J Hypertens 25:1751-62. 2007
- Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studiesM R Law
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
BMJ 338:b1665. 2009To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment.
- Lead exposure and cardiovascular disease--a systematic reviewAna Navas Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 115:472-82. 2007..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations...
- Prevalence and factors associated with circadian blood pressure patterns in hypertensive patientsAlejandro de la Sierra
Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Villarroel 170, E 08036 Barcelona, Spain
Hypertension 53:466-72. 2009Ambulatory blood pressure (BP) monitoring has become useful in the diagnosis and management of hypertensive individuals...
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trialPatricia J Elmer
Kaiser Permanente Northwest, Portland, Oregon 97227, USA
Ann Intern Med 144:485-95. 2006..PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure. OBJECTIVE: To compare the 18-month effects of 2 multicomponent behavioral interventions versus advice only on ..
- Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trialsSeamus P Whelton
Tulane University, New Orleans, Louisiana 70112, USA
Ann Intern Med 136:493-503. 2002PURPOSE: Physical activity has been associated with reduced blood pressure in observational epidemiologic studies and individual clinical trials...
- Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United StatesKatharina Wolf-Maier
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
JAMA 289:2363-9. 2003..OBJECTIVE: To determine whether higher blood pressure (BP) levels and hypertension are more prevalent in Europe than in the United States and Canada...
- Role of the WNK-activated SPAK kinase in regulating blood pressureFatema H Rafiqi
University of Dundee, Scotland, UK
EMBO Mol Med 2:63-75. 2010..To define the importance of this pathway in regulating blood pressure, we generated knock-in mice in which SPAK cannot be activated by WNKs...
- Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome StudyEamon Dolan
The ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
Hypertension 47:365-70. 2006We hypothesized that the dynamic relation between diastolic and systolic blood pressure over 24 hours provides a measure of arterial stiffness and might, therefore, predict cardiovascular mortality over and above pulse pressure...
- Genome-wide association study of blood pressure and hypertensionDaniel Levy
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Nat Genet 41:677-87. 2009b>Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated...
- Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in miceF E Rey
Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202-2689, USA
Circ Res 89:408-14. 2001..kg(-1). d(-1)), or Ang II+scramb-tat intraperitoneally in C57Bl/6 mice and measured systolic blood pressure (SBP) on days 0, 3, 5, and 7 of infusion...
- Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humansRobert D Brook
University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
Hypertension 54:659-67. 2009Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible...
- Long-term effects of parathyroidectomy on hypertension prevalence and circadian blood pressure profile in primary hyperparathyroidismCarlos A Feldstein
Hypertension Program, Hospital de Clinicas Jose de San Martin, School of Medicine, Universidad de Buenos Aires, Buenos Aires 1120, Argentina
Clin Exp Hypertens 32:154-8. 2010..consecutive parathyroidectomized patients, with normalized biochemical measurements, circadian rhythm of blood pressure was evaluated with ambulatory blood pressure monitoring (ABPM). Prevalence of hypertension in PHPT was 54...
- Stress reduction programs in patients with elevated blood pressure: a systematic review and meta-analysisMaxwell V Rainforth
Institute for Natural Medicine and Prevention, Maharishi University of Management, 2100 Mansion Drive, Suite 211, Maharishi Vedic City, IA 52556, USA
Curr Hypertens Rep 9:520-8. 2007..Previous meta-analyses of stress reduction and high blood pressure (BP) were outdated and/or methodologically limited...
- Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndromeJ F Faccenda
Respiratory Medicine Unit and Cardiovascular Unit, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland, United Kingdom
Am J Respir Crit Care Med 163:344-8. 2001Arterial blood pressure rises at apnea termination, and there is increasing evidence that the sleep apnea-hypopnea syndrome (SAHS) is associated with daytime hypertension but no randomized controlled trial evidence of whether SAHS ..
- Blood pressure in Canadian adultsKathryn Wilkins
Health Analysis Division, Statistics Canada, Ottawa, Ontario, K1A 0T6
Health Rep 21:37-46. 2010Hypertension is estimated to cause more than one-eighth of all deaths worldwide. In Canada, the last national surveys to include direct measures of blood pressure (BP) took place over the years 1985-1992; hypertension was estimated at 21%.
- Feasibility of treating prehypertension with an angiotensin-receptor blockerStevo Julius
University of Michigan, Department of Internal Medicine, Division of Cardiovascular Medicine, Ann Arbor, MI 48106, USA
N Engl J Med 354:1685-97. 2006..Prehypertension is considered a precursor of stage 1 hypertension and a predictor of excessive cardiovascular risk. We investigated whether pharmacologic treatment of prehypertension prevents or postpones stage 1 hypertension...
- Environmental mercury exposure and blood pressure among Nunavik Inuit adultsBeatriz Valera
Axe Santé des Populations et Environnement, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
Hypertension 54:981-6. 2009..suggests a negative impact of methylmercury on the cardiovascular system, but findings regarding the effect on blood pressure (BP) are not consistent. We aimed to study the impact of mercury levels on BP among Nunavik Inuit adults...
- Trends in blood pressure among children and adolescentsPaul Muntner
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
JAMA 291:2107-13. 2004The prevalence of overweight among children and adolescents increased between 1988 and 2000. The change in blood pressure among children and adolescents over that time and the role of overweight is unknown.
- Using pedometers to increase physical activity and improve health: a systematic reviewDena M Bravata
Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
JAMA 298:2296-304. 2007..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
- Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart StudyMary J Roman
Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Hypertension 50:197-203. 2007Brachial blood pressure is predictive of cardiovascular outcome; however central pressure may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to vascular damage and ..
- Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deathsSarah Lewington
CTSU, University of Oxford, Oxford OX3 7LF, UK
Lancet 370:1829-39. 2007Age, sex, and blood pressure could modify the associations of total cholesterol (and its main two fractions, HDL and LDL cholesterol) with vascular mortality...
- The effect of walking on fitness, fatness and resting blood pressure: a meta-analysis of randomised, controlled trialsMarie H Murphy
Sport and Exercise Sciences Research Institute, School of Health Sciences, University of Ulster at Jordanstown, Newtownabbey Co Antrim, Northern Ireland, BT37 0QB, UK
Prev Med 44:377-85. 2007..The purpose of this review was to perform a meta-analysis on walking intervention studies in order to quantify the magnitude and direction of walking-induced changes that may alter selected cardiovascular risk factors...
- Telmisartan, ramipril, or both in patients at high risk for vascular eventsSalim Yusuf
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 358:1547-59. 2008..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
- Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trialJackson T Wright
Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
JAMA 288:2421-31. 2002..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
- Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES)Joachim Schrader
Department of Internal Medicine, St. Josefs Hospital, Cloppenburg, Germany
Stroke 36:1218-26. 2005BACKGROUND AND PURPOSE: In hypertensive stroke patients, for the same level of blood pressure control, eprosartan will be more effective than nitrendipine in reducing cerebrovascular and cardiovascular morbidity and mortality...
- Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysisF G R Fowkes
JAMA 300:197-208. 2008..CONCLUSION: Measurement of the ABI may improve the accuracy of cardiovascular risk prediction beyond the FRS...
- Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveformA L Pauca
Anesthesiology Departmen, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Hypertension 38:932-7. 2001..5+/-7.3 and 15.1+/-7.3 mm Hg for nitroglycerin). Use of a generalized transfer function to synthesize radial artery pressure waveforms can provide substantially equivalent values of aortic systolic, pulse, mean, and diastolic pressures...
- Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trialW M Vollmer
Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA
Ann Intern Med 135:1019-28. 2001..Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension...
- The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in miceJanine Pöss
Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
Basic Res Cardiol 105:725-35. 2010..c. for 3-6 weeks, reduced systolic and diastolic blood pressure by -11.5 and -13.7% compared to vehicle...
- Clinical risk factors, DNA variants, and the development of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Lund University, Malmo, Sweden
N Engl J Med 359:2220-32. 2008..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
- National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5·4 million participantsGoodarz Danaei
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Lancet 377:568-77. 2011Data for trends in blood pressure are needed to understand the effects of its dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate national programmes...
- Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort studyAbdullah A Mamun
School of Population Health, University of Queensland, Herston Rd, Herston, QLD 4006, Australia
Circulation 119:1720-7. 2009..with offspring body mass index (BMI) and obesity risk in childhood, but whether this increased risk extends into adulthood or results in increases in other cardiovascular risk factors such as elevated blood pressure (BP) is unclear.
- Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanismAgnes Machnik
Department of Nephrology and Hypertension, and Nikolaus Fiebiger Centre for Molecular Medicine, University Clinic and Friedrich Alexander University of Erlangen Nuremberg, Germany
Nat Med 15:545-52. 2009..interstitial hypertonic volume retention, decreases endothelial nitric oxide synthase expression and elevates blood pressure in response to HSD...
- Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx miceChristopher F Spurney
Division of Cardiology, Children s National Medical Center, Washington, DC, USA
J Cardiovasc Pharmacol Ther 16:87-95. 2011..9% ± 3.5%) mice compared to losartan-treated (32.2% ± 4.2%; P < .01) mice. Systolic blood pressure was significantly reduced in losartan-treated mice (56 ± 6 vs 69 ± 7 mm Hg; P < .0005)...
- Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599Suzanne E Dahlberg
Department of Biostatistics and Computational Biology, CLSB 11007, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 28:949-54. 2010..with nonhypertensive patients with respect to overall survival (OS) and progression-free survival (PFS) using blood pressure data and adverse event data separately...
- Effects of environmental noise exposure on ambulatory blood pressure in young adultsTa Yuan Chang
Department of Occupational Safety and Health, College of Public Health, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan, ROC
Environ Res 109:900-5. 2009..This panel study investigated effects of environmental noise exposure on 24-h ambulatory blood pressure in 60 adults aged 18-32 years...
- Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitorsMichael L Maitland
Department of Medicine, University of Chicago Medical Center, 5841Chicago, IL 60637, USA
J Natl Cancer Inst 102:596-604. 2010..The panel reviewed: the published literature on blood pressure (BP), hypertension, and specific VSP inhibitors; abstracts from major meetings; shared experience with the ..
- Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, AlabamaAlexey Goncharov
Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
J Hypertens 28:2053-60. 2010To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs).
- Prehypertension and mortality in a nationally representative cohortArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Cardiol 94:1496-500. 2004The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure 7 recommendations include early identification of prehypertension (120 to 139 mm Hg systolic or 80 to 89 mm Hg diastolic)...
- The sympathetic control of blood pressurePatrice G Guyenet
Department of Pharmacology, Health Sciences Center, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
Nat Rev Neurosci 7:335-46. 2006Hypertension - the chronic elevation of blood pressure - is a major human health problem...
- Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention studyJing Chen
Department of Medicine and Tulane Hypertension and Renal Center of Excellence, School of Medicine, Tulane University, New Orleans, LA, USA
Lancet 373:829-35. 2009..We aimed to examine the association between metabolic syndrome and salt sensitivity of blood pressure.
- C-reactive protein and the risk of developing hypertensionHoward D Sesso
Department of Medicine, Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215 1204, USA
JAMA 290:2945-51. 2003..Although it has been hypothesized that hypertension is in part an inflammatory disorder, clinical data linking inflammation with incident hypertension are scarce...
- Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) studyBryan Williams
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Circulation 113:1213-25. 2006BACKGROUND: Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP...
- Obesity and the metabolic syndrome in Korean adolescentsSo Yeon Ryu
Department of Preventive Medicine, Chosun University College of Medicine, 375 Seosuk dong, Dong Gu, Gwangju, Korea
J Korean Med Sci 22:513-7. 2007..mg/dL; fasting glucose > or =110 mg/dL; waist circumference >75th percentile for age and gender; and systolic blood pressure >90th percentile for age, gender, and height...
- Midlife blood pressure and dementia: the Honolulu-Asia aging studyL J Launer
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
Neurobiol Aging 21:49-55. 2000We studied the association of mid-life blood pressure to late age dementia, specifically Alzheimer's disease and vascular dementia...
- Subendocardial viability ratio estimated by arterial tonometry: a critical evaluation in elderly hypertensive patients with increased aortic stiffnessDenis Chemla
Paris Sud University, Research Team EA4046, Le Kremlin Bicetre, France
Clin Exp Pharmacol Physiol 35:909-15. 2008..4. The tonometric SEVR was not impaired in elderly hypertensive patients with increased aortic stiffness. In resting elderly and middle-aged individuals, the tonometric SEVR was mainly related to DT/ST ratio, not to aortic pressure...
- Central but not brachial blood pressure predicts cardiovascular events in an unselected geriatric population: the ICARe Dicomano StudyRiccardo Pini
Department of Critical Care Medicine and Surgery Unit of Geriatric Cardiology, University of Firenze and Azienda Ospedaliero Universitaria Careggi, Florence, Italy
J Am Coll Cardiol 51:2432-9. 2008The present study investigated whether central blood pressure (BP) predicts cardiovascular (CV) events better than brachial BP in a cohort of normotensive and untreated hypertensive elderly individuals.
- Association of polychlorinated biphenyls with hypertension in the 1999-2002 National Health and Nutrition Examination SurveyCharles J Everett
Department of Family Medicine, Medical University of South Carolina, 295 Calhoun Street, MSC 192, Charleston, SC 9425 1920, USA
Environ Res 108:94-7. 2008..What clinicians can do, given the results of this study, is limited unless the appropriate laboratory methods can be made more widely available for testing patients...
- Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive ratsDierk H Endemann
CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
Hypertension 43:1252-7. 2004..A group of high-salt SHRSP was also treated with hydralazine (25 mg/kg per day). Blood pressure increased more in high-salt rats than in other groups (P<0.001)...
- Blood pressure differences between northern and southern Chinese: role of dietary factors: the International Study on Macronutrients and Blood PressureLiancheng Zhao
Department of Epidemiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China
Hypertension 43:1332-7. 2004b>Blood pressure and prevalence of high blood pressure are greater for northern than southern Chinese. Reasons for these differences are unclear...
- Heart rate dependency of pulse pressure amplification and arterial stiffnessIan B Wilkinson
Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom
Am J Hypertens 15:24-30. 2002..The aim of the present study was to assess the effect of acute changes in heart rate on arterial stiffness and on peripheral and central pulse pressure in healthy subjects...
- Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial functionBrit Rentzsch
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Hypertension 52:967-73. 2008..Mean arterial blood pressure was reduced in SHRSP-ACE2 compared to SHRSP rats, and the vasoconstrictive response to intraarterial ..
- Salt sensitivity, pulse pressure, and death in normal and hypertensive humansM H Weinberger
Indiana University School of Medicine, The Regenstrief Institute for Health Care, Roudebush Veteran s Administration Medical Center, Indianapolis, Indiana, USA
Hypertension 37:429-32. 2001Although factors such as age, blood pressure, and its responsiveness to changes in sodium balance and extracellular fluid volume status (salt sensitivity) are associated with an increased risk of end-organ disease and cardiovascular ..
- Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteersMilton R Moraes
Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, Brazil
Biol Chem 388:533-40. 2007Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear...
- Contribution of the subfornical organ to angiotensin II-induced hypertensionMichael D Hendel
Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, Minnesota 55108, USA
Am J Physiol Heart Circ Physiol 288:H680-5. 2005..venous catheters and radiotelemetric transducers for intravenous administration of ANG II and measurement of blood pressure and heart rate, respectively. Rats were then allowed 1 wk for recovery...
- Amlodipine attenuates oxidative stress-induced hypertensionAgaba A Ganafa
Department of Pharmacology/Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
Am J Hypertens 17:743-8. 2004..The control animals received drug-free water. Blood pressure (BP) was measured by tail-cuff plethysmography...
- Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspringImran Khan
Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology, and Development, Kings' College, London, UK
Circulation 110:1097-102. 2004..Vascular endothelial function and blood pressure were determined in 180-day-old offspring of fat-fed dams raised on standard chow (FC) or on the fat-rich diet (..
- Leptin and heart sympathetic activity in normotensive obese and non-obese subjectsNorma Amador
Epidemiology Research Unit, Mexican Institute of Social Security,
Ital Heart J 5:29-35. 2004..05). The LF/HF index showed a univariate correlation with body mass index, leptin, systolic blood pressure, insulin, age and triglyceride levels...
- Attenuation of insulin-mediated pressor effect and nitric oxide release in rats with fructose-induced insulin resistancePo Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan, Republic of China
Am J Hypertens 17:707-711. 2004..This study aimed to identify the specific effect of hyperinsulinemia on blood pressure and nitric oxide (NO) release in fructose-induced hyperinsulinemic, insulin-resistant rats...
- Disruption of ultradian and circadian rhythms of blood pressure in nondipper hypertensive patientsSantiago Perez-Lloret
Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina
Hypertension 44:311-5. 2004Ultradian rhythms in blood pressure (BP) are known to exist, but their modification in hypertension is largely unknown...
- Moxonidine in the treatment of overweight and obese patients with the metabolic syndrome: a postmarketing surveillance studyA M Sharma
McMaster University, Hamilton, ON, Canada
J Hum Hypertens 18:669-75. 2004Moxonidine is a centrally active imidazoline receptor agonist that effectively lowers blood pressure and has been shown to have beneficial effects on lipid and carbohydrate metabolism...
- Pulse pressure is more susceptible to the white coat effect than is systolic blood pressure: observations from real-life ambulatory blood pressure monitoringIddo Z Ben-Dov
Department of Internal Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
Am J Hypertens 17:535-9. 2004..We have previously demonstrated ambulatory pulse pressure to be relatively independent from the blood pressure (BP) lowering during sleep, and thus of a neurogenic effect...
- Amlodipine decreases fibrosis and cardiac hypertrophy in spontaneously hypertensive rats: persistent effects after withdrawalMaria A Sevilla
Laboratorio de Farmacognosia y Farmacología, Facultad de Farmacia, Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca 37007, Spain
Life Sci 75:881-91. 2004Our objective was to examine the effect of chronic treatment with amlodipine on blood pressure, left ventricular hypertrophy, and fibrosis in spontaneously hypertensive rats and the persistence of such an effect after drug withdrawal...
- Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in ratsPo Shiuan Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan 114
Metabolism 54:157-64. 2005..role and functional interaction of angiotensin II AT1 and AT2 receptors (AT1R and AT2R) in the regulation of blood pressure and glucose homeostasis in fructose-induced insulin-resistant, hypertensive rats...
- Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive ratsPhilippe Daull
Laval Hospital Research Center, Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada
J Cardiovasc Pharmacol 44:S398-401. 2004..After 15 days, drugs administration was stopped for 3 days. ACEi (1 mg/kg per day) reduced the mean arterial blood pressure by 8.4%. The addition of a NEPi and an ECEi at the same dose did not shown any added benefit...
- Amlodipine/benazepril combination therapy for hypertensive patients nonresponsive to benazepril monotherapySteven G Chrysant
Oklahoma Cardiovascular and Hypertension Center and the University of Oklahoma School of Medicine, Oklahoma City, Oklahoma 73132, USA
Am J Hypertens 17:590-6. 2004Most patients with hypertension require two or more antihypertensive medications to achieve blood pressure (BP) goals...
- Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive ratsToshihiko Ishimitsu
Department of Hypetension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
Am J Hypertens 19:1233-40. 2006..The objective of this study was to evaluate the effect of year-long antihypertensive therapy with a calcium channel blocker and an angiotensin-converting enzyme (ACE) inhibitor on cardiac and renal injury...
- Ovariectomy augments hypertension through rho-kinase activation in the brain stem in female spontaneously hypertensive ratsKoji Ito
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Hypertension 48:651-7. 2006....
- Cardiovascular excitatory effect on rats of a fraction isolated from the eyestalk of shrimp: Peneaus vanameiiFrancisco Rosa
Departamento de Ciencias Fisiologicas, Escuela de Ciencias de la Salud, Nucleo Bolivar, Universidad Central de Venezuela, Caracas
Invest Clin 47:133-41. 2006..2 mL) reduced the effect of CES on mean blood pressure, but not on heart rate. Propranolol pretreatment (4 microg/0...
- Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated ratsJin Wang
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
Acta Pharmacol Sin 27:1013-7. 2006AIM: The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats...
- Effects of angiotensin II type 1 receptor blockade on the systemic blood nitric oxide dynamics in Nomega-nitro-L-arginine methyl ester-treated ratsYasuhisa Kanematsu
Department of Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School of Medical Sciences, Japan
Hypertens Res 29:369-74. 2006..In conclusion, our findings suggested that chronic administration of olmesartan ameliorated the endothelial dysfunction in L-NAME-treated rats...
- Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertensionHiroyuki Sasamura
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Clin Exp Hypertens 28:511-20. 2006..e., after achieving blood pressure reduction) and one year after the initiation of therapy...
- Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxideThiago Santos Moreira
Department of Physiology, , 04023-060, , Brazil
J Cardiovasc Pharmacol 47:780-7. 2006..Therefore, these data indicate that nitric oxide mechanisms are involved in hypotension and mesenteric, renal, and hindquarter vasodilation induced by central moxonidine in normotensive and in acute hypertensive rats...
- Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibitionHidetoshi Okazaki
Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Japan
Hypertens Res 29:277-84. 2006..Eight weeks after treatment, the L-NAME group showed significantly higher systolic blood pressure than the control group (197 +/- 12 vs.138 +/- 5 mmHg, p < 0.05)...
- Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aortaHiroe Toba
Department of Clinical Pharmacology, Kyoto Pharmaceutical University, Kyoto, Japan
Hypertens Res 28:689-700. 2005..To investigate the vasoprotective effects beyond the blood pressure-lowering effects of these agents, amlodipine (20 mg/kg/ day) and manidipine (10 mg/kg/day) were administered ..
- Central actions of agmatine in conscious spontaneously hypertensive ratsS Briaud
Institut de Recherche Neurologique et Cardiovasculaire, , Tours, France
Clin Exp Hypertens 27:619-27. 2005..Agmatine, when administered in low doses (30-100 microg/kg) into the fourth ventricle had no effect on blood pressure and caused an increase in heart rate...
- Neuroprotective effects of candesartan against cerebral ischemia in spontaneously hypertensive ratsQing Lu
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Neuroreport 16:1963-7. 2005....
- Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive ratsKazuhito Hayakawa
Yakult Central Institute for Microbiological Research, Kunitachi shi, Tokyo, Japan
Eur J Pharmacol 524:120-5. 2005..These results suggest that a reduction in the effects induced by the renal nerves may play an important role in the hypotensive effect induced in spontaneously hypertensive rats by chronic dietary administration of GABA...
- Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious ratsMarli Cardoso Martins-Pinge
Department of Physiological Sciences, Center of Biological Sciences, State University of Londrina, Londrina, Parana, Brazil
Auton Neurosci 122:21-8. 2005..These findings suggest that RVLM is involved in the modulation of the sympathetic outflow to the cardiovascular system during exercise training...
- Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of the renin-angiotensin systemTakashi Akasaki
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hypertens Res 29:813-20. 2006..5 mg/kg/day). The high-dose candesartan or the hydralazine plus hydrochlorothiazide decreased the blood pressure of SHRSP to that of WKY, whereas the low-dose candesartan exerted no significant antihypertensive action...
- Neonatal chemical sympathectomy attenuates fructose-induced hypertriglyceridemia and hypertension in ratsP S Hsieh
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, ROC
Chin J Physiol 44:25-31. 2001..Both groups of rats were fed a fructose-enriched diet for 9 weeks. The systolic blood pressure (SBP) and body weight were measured weekly and arterial blood samples were taken weekly for determinations of ..
- Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive ratsTakuya Kishi
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
J Hypertens 21:379-86. 2003OBJECTIVE: Recent studies have suggested that statins decrease blood pressure in hypertensive animals and upregulate endothelial nitric oxide synthase (eNOS) expression...
- Downregulation of basal iNOS at the rostral ventrolateral medulla is innate in SHRJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
Hypertension 41:563-70. 2003..hypertensive rats (SHR) treated for 4 weeks with the antihypertensive captopril to normalize elevated blood pressure or in young prehypertensive SHR, the significantly lower iNOS mRNA and protein levels at the ventrolateral ..
- Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivativeL M Tsai
Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan
J Cardiovasc Pharmacol 38:893-9. 2001..Intravenous administration of DL-017 induced dose-dependent reductions of heart rate and blood pressure, which persisted over 2 h. DL-017 exerted a maximal antihypertensive effect at 0...
- Heart rate and pulse pressure amplification in hypertensive subjectsPierre Laurent
Department of Internal Medicine, Broussais Hospital, Paris, France
Am J Hypertens 16:363-70. 2003BACKGROUND: Although mean blood pressure (MBP) remains unmodified along the arterial tree, pulse pressure (PP) increases physiologically from the central to the peripheral arteries...
- Effect of losartan on oxidative stress-induced hypertension in Sprague-Dawley ratsMohamed A Bayorh
Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
Am J Hypertens 16:387-92. 2003....
- Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic controlHeinrich Holzgreve
Medizinische Poliklinik HH, University of Munich, Munich, Germany
Am J Hypertens 16:381-6. 2003....
- Enhanced angiotensin-mediated responses in the nucleus tractus solitarii of spontaneously hypertensive ratsNobuhide Katsunuma
Second Department of Internal Medicine, Nihon University School of Medicine, 30-1, Oyaguchi-Kamichou, Itabashi-ku, Tokyo 173-8610, Japan
Brain Res Bull 60:209-14. 2003..Thus, stimulation of AT(1) receptors within the NTS contributes to cardiovascular regulation independently of the baroreceptor reflex and the glutamatergic system. This angiotensinergic system in SHR acts tonically to reduce AP...
- [Depressive effect of total flavonoid fraction of Asttragalus complanatus R. Br and its influence upon hemodynamics in SHR]Bing Xue
Department of Pathophysiology, School of Medicine, Shandong University, Jinan, 250012, Shandong, China
Zhongguo Zhong Yao Za Zhi 27:855-8. 2002OBJECTIVE: To investigate effects of total flavonoid fraction of Asttragalus complanatus on blood pressure in conscious spontaneously hypertensive rats(SHR) and hemodynamics in anesthetized SHR...
- Determinants of ambulatory blood pressure response to physical activityMarinel Cavelaars
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
J Hypertens 20:2009-15. 2002..that the association between physical activity, measured with a wrist-worn accelerometer, and ambulatory blood pressure is rather weak and that the inter-individual variation in the degree of association is high...
- Effects of chronic treatment with cromakalim and glibenclamide in alloxan-induced diabetic ratsJayant S Kulkarni
Cadila Pharmaceuticals, Dholka, Ahmedabad 387810, India
Pharmacol Res 46:101-5. 2002..Injection of alloxan (60 mg kg(-1)/i.v., single dose) produced a significant increase in the blood pressure, bradycardia, hyperglycemia, hypoinsulinemia, hyperlipidemia, hypothyroidism and depression in left ..
- Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt ratsClara Di Filippo
Department of Experimental Medicine, Section of Pharmacology L. Donatelli, Research Center for Cardiovascular Diseases, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli 16, Italy
Naunyn Schmiedebergs Arch Pharmacol 366:123-6. 2002..possibly played by ET-receptor antagonism at periaqueductal grey (PAG) area level in decreasing the arterial blood pressure and heart rate values reached in DOCA-salt hypertensive rats...
- FETAL REFLEX RESPONSES TO CEREBRAL HYPOPERFUSIONCharles Wood; Fiscal Year: 1999Fetal sheep respond to hypotension with reflex hormonal and hemodynamic responses which return blood pressure to normal levels...
- Mechanims of CNS Autonomic Regulation by EAJohn C Longhurst; Fiscal Year: 2010..Small trails further suggest that EA can lower elevated blood pressure. Studies conducted in the last two grant cycles have evaluated supra-spinal mechanisms underlying EA's ..
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller Wood; Fiscal Year: 2009..This model also causes reduced fetal blood pressure and increased incidence of fetal hypoxia and fetal and maternal death...
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller Wood; Fiscal Year: 2010..This model also causes reduced fetal blood pressure and increased incidence of fetal hypoxia and fetal and maternal death...
- Older Mothers and Adult Daughters: High Blood Pressure Self Management BehaviorsCeleste Shawler; Fiscal Year: 2010..strength, perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
- Older Mothers and Adult Daughters: High Blood Pressure Self Management BehaviorsCeleste Shawler; Fiscal Year: 2009..strength, perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
- Chicago Endothelial Function StudyLOUISE HAWKLEY; Fiscal Year: 2009_' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
- Chicago Endothelial Function StudyLouise C Hawkley; Fiscal Year: 2010_' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
- IINFLUENCE OF INSULIN ON BLOOD PRESSURE CHANGE DURING ADAlan Sinaiko; Fiscal Year: 1999The primary objective of this research project is to define the relation of insulin resistance to blood pressure in children and to changes in blood pressure that occur during adolescence...
- CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATIONBarry Dworkin; Fiscal Year: 2006..by the applicant): These multi-disciplinary studies target the long-sought physiological link between blood pressure variability and blood pressure regulation...
- The Renal Medulla and HypertensionDavid Stec; Fiscal Year: 2009This project will test the central hypothesis that increased HO-1 in the renal medulla lowers blood pressure in angiotensin II (Ang II) hypertension by inhibiting Ang II induced increases in NADPH oxidase and superoxide production via ..
- The Renal Medulla and HypertensionDavid E Stec; Fiscal Year: 2010This project will test the central hypothesis that increased HO-1 in the renal medulla lowers blood pressure in angiotensin II (Ang II) hypertension by inhibiting Ang II induced increases in NADPH oxidase and superoxide production via ..
- Genotypes, Haplotypes, and Blood Pressure Change from Childhood to AdulthoodDAVID MICHAEL HALLMAN; Fiscal Year: 2010..While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated with levels in adults...
- Genotypes, Haplotypes, and Blood Pressure Change from Childhood to AdulthoodDAVID HALLMAN; Fiscal Year: 2009..While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated with levels in adults...
- Paraventricular nucleus regulatory mechanisms in stress and hypertensionCOLIN contact SUMNERS; Fiscal Year: 2010It is established that the central nervous system (CNS) contributes to the long-term regulation of blood pressure in both health and disease via effects on neuroendocrine mechanisms and sympathetic outflow...
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2010..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2007..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2009..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Angiotensin: A Link Between Obesity and HypertensionLisa Cassis; Fiscal Year: 2007..fat diet (MHF) stimulates the adipose renin-angiotensin system, contributing to obesity-related elevations in blood pressure. Preliminary data demonstrates that rats fed a MHF diet segregate into obesity prone (OP) versus obesity-..
- Behavioral and Physiological Responses to Race-Related Stress in Diabetic WomenJulie Wagner; Fiscal Year: 2007..The stress of exposure to discrimination may contribute to altered blood pressure, glycemia, insulin resistance, and self-care behaviors, thereby increasing risk for complications...
- VESTIBULAR INFLUENCES ON THE SYMPATHETIC NERVOUS SYSTEMBill Yates; Fiscal Year: 2003..Abstract) Research over the past decade has demonstrated that the vestibular system influences the control of blood pressure, both in humans and in animal models...