Genomes and Genes
Summary: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Publications301 found, 100 shown here
- The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportAram V Chobanian
Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
JAMA 289:2560-72. 2003..Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" provides a new guideline for hypertension prevention and management...
- Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureAram V Chobanian
Boston University School of Medicine, Boston, Mass, USA
Hypertension 42:1206-52. 2003The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure...
- 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)Giuseppe Mancia
Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
J Hypertens 25:1105-87. 2007
- Expert consensus document on arterial stiffness: methodological issues and clinical applicationsStephane Laurent
Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
Eur Heart J 27:2588-605. 2006....
- US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008Brent M Egan
Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
JAMA 303:2043-50. 2010Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population.
- Genome-wide association study of blood pressure and hypertensionDaniel Levy
National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
Nat Genet 41:677-87. 2009b>Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated...
- Early goal-directed therapy in the treatment of severe sepsis and septic shockE Rivers
Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
N Engl J Med 345:1368-77. 2001..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
- Multiple imputation of missing blood pressure covariates in survival analysisS van Buuren
TNO Prevention and Health, Department of Statistics, Leiden, The Netherlands
Stat Med 18:681-94. 1999..In a study to determine the influence of blood pressure on survival in the very old (85+ years), blood pressure measurements are missing in about 12...
- Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesSarah Lewington
Lancet 360:1903-13. 2002The age-specific relevance of blood pressure to cause-specific mortality is best assessed by collaborative meta-analysis of individual participant data from the separate prospective studies.
- Genome-wide association study identifies eight loci associated with blood pressureChristopher Newton-Cheh
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Genet 41:666-76. 2009Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2...
- Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studiesM R Law
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
BMJ 338:b1665. 2009To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment.
- Exercise capacity and mortality among men referred for exercise testingJonathan Myers
Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
N Engl J Med 346:793-801. 2002..There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables...
- Prediction of coronary heart disease using risk factor categoriesP W Wilson
Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
Circulation 97:1837-47. 1998The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate ..
- Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deathsSarah Lewington
CTSU, University of Oxford, Oxford OX3 7LF, UK
Lancet 370:1829-39. 2007Age, sex, and blood pressure could modify the associations of total cholesterol (and its main two fractions, HDL and LDL cholesterol) with vascular mortality...
- European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by rIan Graham
Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
Eur Heart J 28:2375-414. 2007
- The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)Rachel P Wildman
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
Arch Intern Med 168:1617-24. 2008....
- Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
- National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5·4 million participantsGoodarz Danaei
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Lancet 377:568-77. 2011Data for trends in blood pressure are needed to understand the effects of its dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate national programmes...
- Arterial stiffness and cardiovascular events: the Framingham Heart StudyGary F Mitchell
Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
Circulation 121:505-11. 2010..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
- Comparison of weight-loss diets with different compositions of fat, protein, and carbohydratesFrank M Sacks
Department of Nutrition, Harvard School of Public Health, Boston, USA
N Engl J Med 360:859-73. 2009..The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year...
- 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial HypertensionGiuseppe Mancia
University of Milano Bicocca, Ospedale San Gerardo, Milan, Italy
J Hypertens 25:1751-62. 2007
- Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort studyDebbie A Lawlor
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol BS8 2BN, UK
BMJ 341:c6224. 2010..To examine the prospective associations between body mass index (BMI), waist circumference, and fat mass in childhood and cardiovascular risk factors at age 15-16...
- European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representIan Graham
Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
- Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research GroupF M Sacks
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
N Engl J Med 344:3-10. 2001The effect of dietary composition on blood pressure is a subject of public health importance...
- Using pedometers to increase physical activity and improve health: a systematic reviewDena M Bravata
Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
JAMA 298:2296-304. 2007..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
- Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarctionBertram Pitt
University of Michigan, Ann Arbor, USA
N Engl J Med 348:1309-21. 2003....
- Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetesHermann Haller
Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
N Engl J Med 364:907-17. 2011..We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria...
- Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east AsiansNorihiro Kato
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Nat Genet 43:531-8. 2011We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) ..
- Cardiometabolic risk variables in overweight and obese children: a worldwide comparisonMariska van Vliet
Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
Cardiovasc Diabetol 10:106. 2011..to compare the means of glucose and lipid levels (triglycerides and HDL-cholesterol) and systolic/diastolic blood pressure values...
- Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factorsVéronique A Cornelissen
Department of Molecular and Cardiovascular Research, Catholic University of Leuven, Belgium
Hypertension 46:667-75. 2005..meta-analyses of randomized controlled trials on the effects of chronic dynamic aerobic endurance training on blood pressure reported on resting blood pressure only...
- Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trialRamon Estruch
Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
Ann Intern Med 145:1-11. 2006..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
- Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programmingAnne Maj Samuelsson
Division of Reproduction and Endocrinology, King s College London, London, UK
Hypertension 51:383-92. 2008..endothelial dysfunction at 3 months, and were hypertensive, as assessed by radiotelemetry (nighttime systolic blood pressure at 6 months [mm Hg] mean+/-SEM, male OO, 134+/-1 versus OC, 124+/-2, n=8, P<0...
- A comprehensive review on salt and health and current experience of worldwide salt reduction programmesF J He
Blood Pressure Unit, Cardiac and Vascular Sciences, St George s, University of London, London, UK
J Hum Hypertens 23:363-84. 2009Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Raised blood pressure (BP), cholesterol and smoking, are the major risk factors...
- From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility geneYing Wang
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 106:226-31. 2009..We conducted a genome-wide association study of systolic and diastolic blood pressure (SBP and DBP) in Amish subjects and found strong association signals with common variants in a serine/..
- A genome-wide association study of hypertension and blood pressure in African AmericansAdebowale Adeyemo
Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
PLoS Genet 5:e1000564. 2009..We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the ..
- Blood pressure and inflammation in apparently healthy menC U Chae
Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Hypertension 38:399-403. 2001..In a cross-sectional study involving 508 apparently healthy men, we studied the association between blood pressure and baseline plasma concentrations of 2 inflammatory markers, intercellular adhesion molecule-1 (sICAM-1) and ..
- Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year periodAthanase Benetos
Centre d Investigations Préventives et Cliniques, Paris, France
Circulation 105:1202-7. 2002..The aim of the present longitudinal study was to compare the progression of aortic stiffness over a 6-year period in treated hypertensive subjects and normotensive subjects, and to evaluate the determinants of this progression...
- Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysisTazeen H Jafar
Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Ann Intern Med 139:244-52. 2003Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease.
- Predictors of long-term progression in the early manifest glaucoma trialM Cristina Leske
Department of Preventive Medicine, Stony Brook University Medical Center, Stony Brook, New York 11794 8036, USA
Ophthalmology 114:1965-72. 2007..To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split)...
- Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanismM Mazzali
Division of Nephrology, University of Washington Medical Center, Seattle, USA
Hypertension 38:1101-6. 2001..Hyperuricemic rats developed elevated blood pressure after 3 weeks, whereas control rats remained normotensive...
- Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trialRena R Wing
Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
Arch Intern Med 170:1566-75. 2010..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
- Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studiesPasquale Strazzullo
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy
BMJ 339:b4567. 2009..To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome...
- Comparison of the novel angiotensin II receptor blocker azilsartan medoxomil vs valsartan by ambulatory blood pressure monitoringDomenic Sica
Section of Clinical Pharmacology and Hypertension, Virginia Commonwealth University, Richmond, VA 23298 0160, USA
J Clin Hypertens (Greenwich) 13:467-72. 2011..with primary hypertension in a randomized, double-blind, multicenter study using ambulatory and clinic blood pressure (BP) measurements...
- Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adultsKim Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Circulation 111:3384-90. 2005..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
- Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysisF G R Fowkes
JAMA 300:197-208. 2008..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
- Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysisXiaoli Chen
Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
Circulation 117:3171-80. 2008A large number of studies have examined the tracking of blood pressure (BP) from childhood to adulthood, but the reported findings are inconsistent and few systematic analyses have been conducted.
- Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial functionBrit Rentzsch
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
Hypertension 52:967-73. 2008..Mean arterial blood pressure was reduced in SHRSP-ACE2 compared to SHRSP rats, and the vasoconstrictive response to intraarterial ..
- 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth CohortElina Hypponen
Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
Diabetes 57:298-305. 2008..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
- Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertensionSandosh Padmanabhan
Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
PLoS Genet 6:e1001177. 2010..The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk...
- Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular riskRod Jackson
Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Lancet 365:434-41. 2005In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels...
- Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in miceF E Rey
Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202-2689, USA
Circ Res 89:408-14. 2001..kg(-1). d(-1)), or Ang II+scramb-tat intraperitoneally in C57Bl/6 mice and measured systolic blood pressure (SBP) on days 0, 3, 5, and 7 of infusion...
- Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertensionWilliam B White
Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology Center, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3940, USA
Hypertension 57:413-20. 2011..medoxomil (olmesartan) 40 mg, in a randomized, double-blind, placebo-controlled trial using ambulatory blood pressure (BP) monitoring and clinic BP measurements...
- Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United StatesKatharina Wolf-Maier
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
JAMA 289:2363-9. 2003..Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America...
- The sympathetic control of blood pressurePatrice G Guyenet
Department of Pharmacology, Health Sciences Center, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
Nat Rev Neurosci 7:335-46. 2006Hypertension - the chronic elevation of blood pressure - is a major human health problem...
- Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertensionCarine M Boustany
Graduate Center for Nutritional Sciences, Rm 521b, Charles T Wethington Bldg, Univ of Kentucky, Lexington, KY 40536 0200, USA
Am J Physiol Regul Integr Comp Physiol 287:R943-9. 2004..05). Mean arterial blood pressure was increased in OP rats (LF: 97 +/- 2; OR: 97 +/- 2; OP: 105 +/- 1 mmHg; P < 0.05)...
- Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular diseaseEdward G Lakatta
Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
Circulation 107:139-46. 2003
- Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndromeAimin Xu
Department of Medicine, University of Hong Kong, Hong Kong, China
Clin Chem 52:405-13. 2006..Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed...
- A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderlyLindon M H Wing
School of Medicine, Flinders University, Adelaide, Australia
N Engl J Med 348:583-92. 2003..been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of blood pressure alone...
- H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among African AmericansJamie M Zoellner
Department of Human Nutrition, Foods and Exercise, Virginia Tech, 1981 Kraft Drive 0913, Blacksburg, VA 24061, USA
Int J Behav Nutr Phys Act 8:59. 2011..This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes.
- Blood pressure control in Italy: results of recent surveys on hypertensionMassimo Volpe
Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
J Hypertens 25:1491-8. 2007b>Blood pressure (BP) control is reported to be poor in hypertensive patients worldwide.
- The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literatureR R Huxley
Division of Public Health and Primary Health Care, Institute of Health Sciences, Oxford, UK
J Hypertens 18:815-31. 2000To conduct a systematic review in order to (i) summarize the relationship between birthweight and blood pressure, following numerous publications in the last 3 years, (ii) assess whether other measures of size at birth are related to ..
- Trends in utilization of lipid- and blood pressure-lowering agents and goal attainment among the U.S. diabetic population, 1999-2008Andreas Kuznik
Pfizer Inc, New York, New York, USA
Cardiovasc Diabetol 10:31. 2011..59 mmol/L (100 mg/dL) and a blood pressure (BP) target of <130/80 mmHg...
- Brain angiotensin peptides regulate sympathetic tone and blood pressureAlain G Dupont
Department of Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
J Hypertens 28:1599-610. 2010..Angiotensin III and Angiotensin IV increase blood pressure via brain AT1 receptor stimulation...
- Angiotensin-converting enzyme 2 is an essential regulator of heart functionMichael A Crackower
Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
Nature 417:822-8. 2002..But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo...
- Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trialPatricia J Elmer
Kaiser Permanente Northwest, Portland, Oregon 97227, USA
Ann Intern Med 144:485-95. 2006The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure.
- Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trialsSeamus P Whelton
Tulane University, New Orleans, Louisiana 70112, USA
Ann Intern Med 136:493-503. 2002Physical activity has been associated with reduced blood pressure in observational epidemiologic studies and individual clinical trials...
- Lead exposure and cardiovascular disease--a systematic reviewAna Navas-Acien
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 115:472-82. 2007..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations...
- Prevalence and factors associated with circadian blood pressure patterns in hypertensive patientsAlejandro de la Sierra
Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Villarroel 170, E 08036 Barcelona, Spain
Hypertension 53:466-72. 2009Ambulatory blood pressure (BP) monitoring has become useful in the diagnosis and management of hypertensive individuals...
- Role of the WNK-activated SPAK kinase in regulating blood pressureFatema H Rafiqi
University of Dundee, Scotland, UK
EMBO Mol Med 2:63-75. 2010..To define the importance of this pathway in regulating blood pressure, we generated knock-in mice in which SPAK cannot be activated by WNKs...
- Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome StudyEamon Dolan
The ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
Hypertension 47:365-70. 2006We hypothesized that the dynamic relation between diastolic and systolic blood pressure over 24 hours provides a measure of arterial stiffness and might, therefore, predict cardiovascular mortality over and above pulse pressure...
- Environmental mercury exposure and blood pressure among Nunavik Inuit adultsBeatriz Valera
Axe Santé des Populations et Environnement, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec, Canada
Hypertension 54:981-6. 2009..suggests a negative impact of methylmercury on the cardiovascular system, but findings regarding the effect on blood pressure (BP) are not consistent. We aimed to study the impact of mercury levels on BP among Nunavik Inuit adults...
- Long-term effects of parathyroidectomy on hypertension prevalence and circadian blood pressure profile in primary hyperparathyroidismCarlos A Feldstein
Hypertension Program, Hospital de Clinicas Jose de San Martin, School of Medicine, Universidad de Buenos Aires, Buenos Aires 1120, Argentina
Clin Exp Hypertens 32:154-8. 2010..consecutive parathyroidectomized patients, with normalized biochemical measurements, circadian rhythm of blood pressure was evaluated with ambulatory blood pressure monitoring (ABPM). Prevalence of hypertension in PHPT was 54...
- Feasibility of treating prehypertension with an angiotensin-receptor blockerStevo Julius
University of Michigan, Department of Internal Medicine, Division of Cardiovascular Medicine, Ann Arbor, MI 48106, USA
N Engl J Med 354:1685-97. 2006..Prehypertension is considered a precursor of stage 1 hypertension and a predictor of excessive cardiovascular risk. We investigated whether pharmacologic treatment of prehypertension prevents or postpones stage 1 hypertension...
- Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndromeJ F Faccenda
Respiratory Medicine Unit and Cardiovascular Unit, University of Edinburgh, Royal Infirmary, Edinburgh, Scotland, United Kingdom
Am J Respir Crit Care Med 163:344-8. 2001Arterial blood pressure rises at apnea termination, and there is increasing evidence that the sleep apnea-hypopnea syndrome (SAHS) is associated with daytime hypertension but no randomized controlled trial evidence of whether SAHS ..
- Stress reduction programs in patients with elevated blood pressure: a systematic review and meta-analysisMaxwell V Rainforth
Institute for Natural Medicine and Prevention, Maharishi University of Management, 2100 Mansion Drive, Suite 211, Maharishi Vedic City, IA 52556, USA
Curr Hypertens Rep 9:520-8. 2007..Previous meta-analyses of stress reduction and high blood pressure (BP) were outdated and/or methodologically limited...
- Blood pressure in Canadian adultsKathryn Wilkins
Health Analysis Division, Statistics Canada, Ottawa, Ontario, K1A 0T6
Health Rep 21:37-46. 2010Hypertension is estimated to cause more than one-eighth of all deaths worldwide. In Canada, the last national surveys to include direct measures of blood pressure (BP) took place over the years 1985-1992; hypertension was estimated at 21%.
- Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humansRobert D Brook
University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
Hypertension 54:659-67. 2009Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible...
- Trends in blood pressure among children and adolescentsPaul Muntner
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
JAMA 291:2107-13. 2004The prevalence of overweight among children and adolescents increased between 1988 and 2000. The change in blood pressure among children and adolescents over that time and the role of overweight is unknown.
- Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES)Joachim Schrader
Department of Internal Medicine, St Josefs Hospital, Cloppenburg, Germany
Stroke 36:1218-26. 2005In hypertensive stroke patients, for the same level of blood pressure control, eprosartan will be more effective than nitrendipine in reducing cerebrovascular and cardiovascular morbidity and mortality.
- The effect of walking on fitness, fatness and resting blood pressure: a meta-analysis of randomised, controlled trialsMarie H Murphy
Sport and Exercise Sciences Research Institute, School of Health Sciences, University of Ulster at Jordanstown, Newtownabbey Co Antrim, Northern Ireland, BT37 0QB, UK
Prev Med 44:377-85. 2007..The purpose of this review was to perform a meta-analysis on walking intervention studies in order to quantify the magnitude and direction of walking-induced changes that may alter selected cardiovascular risk factors...
- Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart StudyMary J Roman
Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Hypertension 50:197-203. 2007Brachial blood pressure is predictive of cardiovascular outcome; however central pressure may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to vascular damage and ..
- Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trialJackson T Wright
Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
JAMA 288:2421-31. 2002..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
- Telmisartan, ramipril, or both in patients at high risk for vascular eventsSalim Yusuf
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 358:1547-59. 2008..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
- Clinical course of advanced non-small-cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599Suzanne E Dahlberg
Department of Biostatistics and Computational Biology, CLSB 11007, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 28:949-54. 2010..with nonhypertensive patients with respect to overall survival (OS) and progression-free survival (PFS) using blood pressure data and adverse event data separately...
- Clinical risk factors, DNA variants, and the development of type 2 diabetesValeriya Lyssenko
Department of Clinical Sciences, Lund University, Malmo, Sweden
N Engl J Med 359:2220-32. 2008..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
- Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanismAgnes Machnik
Department of Nephrology and Hypertension, and Nikolaus Fiebiger Centre for Molecular Medicine, University Clinic and Friedrich Alexander University of Erlangen Nuremberg, Germany
Nat Med 15:545-52. 2009..interstitial hypertonic volume retention, decreases endothelial nitric oxide synthase expression and elevates blood pressure in response to HSD...
- Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trialW M Vollmer
Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA
Ann Intern Med 135:1019-28. 2001..Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension...
- The renin inhibitor aliskiren upregulates pro-angiogenic cells and reduces atherogenesis in miceJanine Pöss
Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrbergerstr, 66421, Homburg, Saar, Germany
Basic Res Cardiol 105:725-35. 2010..c. for 3-6 weeks, reduced systolic and diastolic blood pressure by -11.5 and -13.7% compared to vehicle...
- Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort studyAbdullah A Mamun
School of Population Health, University of Queensland, Herston Rd, Herston, QLD 4006, Australia
Circulation 119:1720-7. 2009..with offspring body mass index (BMI) and obesity risk in childhood, but whether this increased risk extends into adulthood or results in increases in other cardiovascular risk factors such as elevated blood pressure (BP) is unclear.
- Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveformA L Pauca
Anesthesiology Departmen, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Hypertension 38:932-7. 2001..5+/-7.3 and 15.1+/-7.3 mm Hg for nitroglycerin). Use of a generalized transfer function to synthesize radial artery pressure waveforms can provide substantially equivalent values of aortic systolic, pulse, mean, and diastolic pressures...
- Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx miceChristopher F Spurney
Division of Cardiology, Children s National Medical Center, Washington, DC, USA
J Cardiovasc Pharmacol Ther 16:87-95. 2011..9% ± 3.5%) mice compared to losartan-treated (32.2% ± 4.2%; P < .01) mice. Systolic blood pressure was significantly reduced in losartan-treated mice (56 ± 6 vs 69 ± 7 mm Hg; P < .0005)...
- Midlife blood pressure and dementia: the Honolulu-Asia aging studyL J Launer
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C 309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA
Neurobiol Aging 21:49-55. 2000We studied the association of mid-life blood pressure to late age dementia, specifically Alzheimer's disease and vascular dementia...
- Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive ratsDierk H Endemann
CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Canada
Hypertension 43:1252-7. 2004..A group of high-salt SHRSP was also treated with hydralazine (25 mg/kg per day). Blood pressure increased more in high-salt rats than in other groups (P<0.001)...
- Blood pressure differences between northern and southern Chinese: role of dietary factors: the International Study on Macronutrients and Blood PressureLiancheng Zhao
Department of Epidemiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, People s Republic of China
Hypertension 43:1332-7. 2004b>Blood pressure and prevalence of high blood pressure are greater for northern than southern Chinese. Reasons for these differences are unclear...
- Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitorsMichael L Maitland
Department of Medicine, University of Chicago Medical Center, 5841Chicago, IL 60637, USA
J Natl Cancer Inst 102:596-604. 2010..The panel reviewed: the published literature on blood pressure (BP), hypertension, and specific VSP inhibitors; abstracts from major meetings; shared experience with the ..
- Prehypertension and mortality in a nationally representative cohortArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Cardiol 94:1496-500. 2004The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure 7 recommendations include early identification of prehypertension (120 to 139 mm Hg systolic or 80 to 89 mm Hg diastolic)...
- Effects of environmental noise exposure on ambulatory blood pressure in young adultsTa Yuan Chang
Department of Occupational Safety and Health, College of Public Health, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan, ROC
Environ Res 109:900-5. 2009..This panel study investigated effects of environmental noise exposure on 24-h ambulatory blood pressure in 60 adults aged 18-32 years...
- Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) studyBryan Williams
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Circulation 113:1213-25. 2006Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP...
- Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention studyJing Chen
Department of Medicine and Tulane Hypertension and Renal Center of Excellence, School of Medicine, Tulane University, New Orleans, LA, USA
Lancet 373:829-35. 2009..We aimed to examine the association between metabolic syndrome and salt sensitivity of blood pressure.
- Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteersMilton R Moraes
Department of Biophysics, Federal University of Sao Paulo, Sao Paulo, Brazil
Biol Chem 388:533-40. 2007Post-exercise hypotension is an important event for blood pressure regulation, especially in hypertensive individuals. Although post-exercise hypotension is a well-known phenomenon, the mechanism responsible is still unclear...
- Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, AlabamaAlexey Goncharov
Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
J Hypertens 28:2053-60. 2010To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs).
- FETAL REFLEX RESPONSES TO CEREBRAL HYPOPERFUSIONCharles Wood; Fiscal Year: 1999Fetal sheep respond to hypotension with reflex hormonal and hemodynamic responses which return blood pressure to normal levels...
- Mechanims of CNS Autonomic Regulation by EAJohn C Longhurst; Fiscal Year: 2010..Small trails further suggest that EA can lower elevated blood pressure. Studies conducted in the last two grant cycles have evaluated supra-spinal mechanisms underlying EA's ..
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller Wood; Fiscal Year: 2009..This model also causes reduced fetal blood pressure and increased incidence of fetal hypoxia and fetal and maternal death...
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller Wood; Fiscal Year: 2010..This model also causes reduced fetal blood pressure and increased incidence of fetal hypoxia and fetal and maternal death...
- Older Mothers and Adult Daughters: High Blood Pressure Self Management BehaviorsCeleste Shawler; Fiscal Year: 2010..strength, perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
- Older Mothers and Adult Daughters: High Blood Pressure Self Management BehaviorsCeleste Shawler; Fiscal Year: 2009..strength, perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
- Chicago Endothelial Function StudyLOUISE HAWKLEY; Fiscal Year: 2009_' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
- Chicago Endothelial Function StudyLouise C Hawkley; Fiscal Year: 2010_' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
- IINFLUENCE OF INSULIN ON BLOOD PRESSURE CHANGE DURING ADAlan Sinaiko; Fiscal Year: 1999The primary objective of this research project is to define the relation of insulin resistance to blood pressure in children and to changes in blood pressure that occur during adolescence...
- The Renal Medulla and HypertensionDavid Stec; Fiscal Year: 2009This project will test the central hypothesis that increased HO-1 in the renal medulla lowers blood pressure in angiotensin II (Ang II) hypertension by inhibiting Ang II induced increases in NADPH oxidase and superoxide production via ..
- The Renal Medulla and HypertensionDavid E Stec; Fiscal Year: 2010This project will test the central hypothesis that increased HO-1 in the renal medulla lowers blood pressure in angiotensin II (Ang II) hypertension by inhibiting Ang II induced increases in NADPH oxidase and superoxide production via ..
- CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATIONBarry Dworkin; Fiscal Year: 2006..by the applicant): These multi-disciplinary studies target the long-sought physiological link between blood pressure variability and blood pressure regulation...
- Role of the renin-angiotensin system in sexual dimorphisms in the development ofJennifer C Sullivan; Fiscal Year: 2010..Approximately 65% of hypertensive patients do not have their blood pressure controlled and women are more likely than men to have uncontrolled blood pressure...
- Genotypes, Haplotypes, and Blood Pressure Change from Childhood to AdulthoodDAVID MICHAEL HALLMAN; Fiscal Year: 2010..While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated with levels in adults...
- Genotypes, Haplotypes, and Blood Pressure Change from Childhood to AdulthoodDAVID HALLMAN; Fiscal Year: 2009..While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated with levels in adults...
- Paraventricular nucleus regulatory mechanisms in stress and hypertensionCOLIN contact SUMNERS; Fiscal Year: 2010It is established that the central nervous system (CNS) contributes to the long-term regulation of blood pressure in both health and disease via effects on neuroendocrine mechanisms and sympathetic outflow...
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2007..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2010..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Mechanisms of Meditation in Hypertension in BlacksRobert Schneider; Fiscal Year: 2009..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
- Angiotensin: A Link Between Obesity and HypertensionLisa Cassis; Fiscal Year: 2007..fat diet (MHF) stimulates the adipose renin-angiotensin system, contributing to obesity-related elevations in blood pressure. Preliminary data demonstrates that rats fed a MHF diet segregate into obesity prone (OP) versus obesity-..
- Behavioral and Physiological Responses to Race-Related Stress in Diabetic WomenJulie Wagner; Fiscal Year: 2007..The stress of exposure to discrimination may contribute to altered blood pressure, glycemia, insulin resistance, and self-care behaviors, thereby increasing risk for complications...
- VESTIBULAR INFLUENCES ON THE SYMPATHETIC NERVOUS SYSTEMBill Yates; Fiscal Year: 2003..Abstract) Research over the past decade has demonstrated that the vestibular system influences the control of blood pressure, both in humans and in animal models...