blood pressure

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Summary: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

Top Publications

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
  2. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
  3. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  4. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
  5. ncbi Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
  6. ncbi US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    JAMA 303:2043-50. 2010
  7. ncbi 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
    Paul A James
    University of Iowa, Iowa City
    JAMA 311:507-20. 2014
  8. ncbi 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  9. ncbi Multiple imputation of missing blood pressure covariates in survival analysis
    S van Buuren
    TNO Prevention and Health, Department of Statistics, Leiden, The Netherlands
    Stat Med 18:681-94. 1999
  10. ncbi Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    F M Sacks
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:3-10. 2001

Detail Information

Publications329 found, 100 shown here

  1. ncbi The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure" provides a new guideline for hypertension prevention and management...
  2. ncbi Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    Aram V Chobanian
    Boston University School of Medicine, Boston, Mass, USA
    Hypertension 42:1206-52. 2003
    The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure...
  3. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    The objective of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate ..
  4. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
    The age-specific relevance of blood pressure to cause-specific mortality is best assessed by collaborative meta-analysis of individual participant data from the separate prospective studies.
  5. ncbi Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
    ....
  6. ncbi US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008
    Brent M Egan
    Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave, 1230 RT, Charleston, SC 29425, USA
    JAMA 303:2043-50. 2010
    Hypertension is a major risk factor for cardiovascular disease and treatment and control of hypertension reduces risk. The Healthy People 2010 goal was to achieve blood pressure (BP) control in 50% of the US population.
  7. ncbi 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)
    Paul A James
    University of Iowa, Iowa City
    JAMA 311:507-20. 2014
    ..Patients want to be assured that blood pressure (BP) treatment will reduce their disease burden, while clinicians want guidance on hypertension management ..
  8. ncbi 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
    Giuseppe Mancia
    Clinica Medica, Ospedale San Gerardo, Universita Milano Bicocca, Via Pergolesi, 33 20052 MONZA Milano, Italy
    J Hypertens 25:1105-87. 2007
  9. ncbi Multiple imputation of missing blood pressure covariates in survival analysis
    S van Buuren
    TNO Prevention and Health, Department of Statistics, Leiden, The Netherlands
    Stat Med 18:681-94. 1999
    ..In a study to determine the influence of blood pressure on survival in the very old (85+ years), blood pressure measurements are missing in about 12...
  10. ncbi Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    F M Sacks
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:3-10. 2001
    The effect of dietary composition on blood pressure is a subject of public health importance...
  11. ncbi The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
    Arch Intern Med 168:1617-24. 2008
    ....
  12. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  13. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
    ..There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables...
  14. pmc Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
    M R Law
    Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 338:b1665. 2009
    To determine the quantitative efficacy of different classes of blood pressure lowering drugs in preventing coronary heart disease (CHD) and stroke, and who should receive treatment.
  15. pmc Arterial stiffness and cardiovascular events: the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering, Inc, 1 Edgewater Dr, Suite 201A, Norwood, MA 02062, USA
    Circulation 121:505-11. 2010
    ..Various measures of arterial stiffness and wave reflection have been proposed as cardiovascular risk markers. Prior studies have not assessed relations of a comprehensive panel of stiffness measures to prognosis in the community...
  16. ncbi National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5·4 million participants
    Goodarz Danaei
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet 377:568-77. 2011
    Data for trends in blood pressure are needed to understand the effects of its dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate national programmes...
  17. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  18. ncbi A comprehensive review on salt and health and current experience of worldwide salt reduction programmes
    F J He
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s, University of London, London, UK
    J Hum Hypertens 23:363-84. 2009
    Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Raised blood pressure (BP), cholesterol and smoking, are the major risk factors...
  19. ncbi Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Kennedy Cruickshank
    Clinical Epidemiology Group, School of Epidemiology and Health Sciences, University of Manchester Medical School, Manchester, UK
    Circulation 106:2085-90. 2002
    ..We tested whether aortic PWV predicts cardiovascular and all-cause mortality in type 2 diabetes and glucose-tolerance-tested (GTT) multiethnic population samples...
  20. ncbi Using pedometers to increase physical activity and improve health: a systematic review
    Dena M Bravata
    Center for Primary Care and Outcomes Research, Stanford University, Stanford, California, USA
    JAMA 298:2296-304. 2007
    ..Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity...
  21. ncbi Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    Bertram Pitt
    University of Michigan, Ann Arbor, USA
    N Engl J Med 348:1309-21. 2003
    ....
  22. ncbi Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    Sarah Lewington
    CTSU, University of Oxford, Oxford OX3 7LF, UK
    Lancet 370:1829-39. 2007
    Age, sex, and blood pressure could modify the associations of total cholesterol (and its main two fractions, HDL and LDL cholesterol) with vascular mortality...
  23. ncbi Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP...
  24. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  25. pmc Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Naples, Italy
    BMJ 339:b4567. 2009
    ..To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome...
  26. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..endothelial dysfunction at 3 months, and were hypertensive, as assessed by radiotelemetry (nighttime systolic blood pressure at 6 months [mm Hg] mean+/-SEM, male OO, 134+/-1 versus OC, 124+/-2, n=8, P<0...
  27. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009
    ..The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year...
  28. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce blood pressure (BP). The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP...
  29. pmc Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure
    Barbara Hoffmann
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:241-6. 2012
    ..Diabetes increases the risk of hypertension and orthostatic hypotension and raises the risk of cardiovascular death during heat waves and high pollution episodes...
  30. pmc Aortic stiffness, blood pressure progression, and incident hypertension
    Bernhard M Kaess
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    JAMA 308:875-81. 2012
    ..Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiffening and blood pressure ..
  31. ncbi 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension
    Giuseppe Mancia
    University of Milano Bicocca, Ospedale San Gerardo, Milan, Italy
    J Hypertens 25:1751-62. 2007
  32. ncbi Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States
    Katharina Wolf-Maier
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill 60153, USA
    JAMA 289:2363-9. 2003
    ..Geographic variations in cardiovascular disease (CVD) and associated risk factors have been recognized worldwide. However, little attention has been directed to potential differences in hypertension between Europe and North America...
  33. ncbi Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study)
    Lars Bo Andersen
    Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
    Lancet 368:299-304. 2006
    ..This study's aim was to assess the associations of objectively measured physical activity with clustering of cardiovascular disease risk factors in children and derive guidelines on the basis of this analysis...
  34. ncbi Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Naples, Italy
    JAMA 292:1440-6. 2004
    ..The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood...
  35. pmc Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol BS8 2BN, UK
    BMJ 341:c6224. 2010
    ..To examine the prospective associations between body mass index (BMI), waist circumference, and fat mass in childhood and cardiovascular risk factors at age 15-16...
  36. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  37. ncbi Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    Peter M Rothwell
    Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK
    Lancet 375:895-905. 2010
    ..Guidelines for diagnosis and treatment focus only on underlying mean blood pressure. We aimed to reliably establish the prognostic significance of visit-to-visit variability in blood pressure, ..
  38. ncbi Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension: the National Health And Nutrition Examination Survey, 2001 to 2010
    Qiuping Gu
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Center for Disease Control and Prevention, Room 4333, 3311 Toledo Rd, Hyattsville, MD 20782, USA
    Circulation 126:2105-14. 2012
    ..The objective of this study was to examine recent trends in antihypertensive medication use and its impact on blood pressure control among US adults with hypertension.
  39. ncbi Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study
    Jonna Juhola
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Central Hospital, Turku, Finland
    J Pediatr 159:584-90. 2011
    To examine tracking and predictiveness of childhood lipid levels, blood pressure, and body mass index for risk profile in adulthood and the best age to measure the childhood risk factor levels.
  40. ncbi Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials
    Vanessa Ha
    Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ontario, Canada
    Hypertension 59:787-95. 2012
    Concerns have been raised about the adverse effect of fructose on blood pressure. International dietary guidelines, however, have not addressed fructose intake directly...
  41. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    b>Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated...
  42. ncbi GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    Minsuk Kim
    Department of Medicine, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Nat Med 19:567-75. 2013
    ..atria and that GLP-1R activation promotes the secretion of atrial natriuretic peptide (ANP) and a reduction of blood pressure. Consistent with an indirect ANP-dependent mechanism for the antihypertensive effects of GLP-1R activation, ..
  43. ncbi European Society of Hypertension position paper on ambulatory blood pressure monitoring
    Eoin O'Brien
    Eoin O Brien, Gianfranco Parati, and George Stergiou contributed equally to the writing of this article The affiliations of the co authors are listed at the end of the paper, preceding the reference list
    J Hypertens 31:1731-68. 2013
    Ambulatory blood pressure monitoring (ABPM) is being used increasingly in both clinical practice and hypertension research...
  44. ncbi European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement
    Eoin O'Brien
    J Hypertens 21:821-48. 2003
  45. ncbi Intensive glucose control and macrovascular outcomes in type 2 diabetes
    F M Turnbull
    The George Institute for International Health, University of Sydney, Sydney, NSW 2050, Australia
    Diabetologia 52:2288-98. 2009
    ..The aim of these analyses was to generate more precise estimates of the effects of more-intensive, compared with less-intensive, glucose control on the risk of major cardiovascular events amongst patients with type 2 diabetes...
  46. ncbi Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hypertension 50:197-203. 2007
    Brachial blood pressure is predictive of cardiovascular outcome; however central pressure may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to vascular damage and ..
  47. ncbi Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials. Implications for public health
    F J He
    Blood Pressure Unit, St George s Hospital Medical School, London, UK
    J Hum Hypertens 16:761-70. 2002
    ..We carried out a meta-analysis to assess the effect of a modest salt reduction on blood pressure. Our data sources were MEDLINE, EMBASE, Cochrane library, CINAHL, and the reference lists of original and ..
  48. pmc Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    JAMA 304:1795-802. 2010
    ....
  49. ncbi Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors
    Véronique A Cornelissen
    Department of Molecular and Cardiovascular Research, Catholic University of Leuven, Belgium
    Hypertension 46:667-75. 2005
    ..meta-analyses of randomized controlled trials on the effects of chronic dynamic aerobic endurance training on blood pressure reported on resting blood pressure only...
  50. ncbi Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study
    Eamon Dolan
    ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland
    Hypertension 46:156-61. 2005
    The purpose of this study was to determine if ambulatory blood pressure measurement predicted total and cardiovascular mortality over and beyond clinic blood pressure measurement and other cardiovascular risk factors; 5292 untreated ..
  51. ncbi Treatment of hypertension in patients 80 years of age or older
    Nigel S Beckett
    Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
    N Engl J Med 358:1887-98. 2008
    ..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
  52. pmc Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis
    Xiaoli Chen
    Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Circulation 117:3171-80. 2008
    A large number of studies have examined the tracking of blood pressure (BP) from childhood to adulthood, but the reported findings are inconsistent and few systematic analyses have been conducted.
  53. ncbi Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring
    Alejandro de la Sierra
    Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Plaza Dr Robert 5, 08221 Terrassa, Spain
    Hypertension 57:898-902. 2011
    We aimed to estimate the prevalence of resistant hypertension through both office and ambulatory blood pressure monitoring in a large cohort of treated hypertensive patients from the Spanish Ambulatory Blood Pressure Monitoring Registry...
  54. pmc Genome-wide association study identifies eight loci associated with blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 41:666-76. 2009
    Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2...
  55. ncbi Hypertension prevalence, awareness, treatment, and control in mozambique: urban/rural gap during epidemiological transition
    Albertino Damasceno
    Eduardo Mondlane University, Maputo, Mozambique
    Hypertension 54:77-83. 2009
    ..Prevalence of hypertension (systolic blood pressure > or =140 mm Hg and/or diastolic blood pressure > or =90 mm Hg and/or antihypertensive drug therapy), ..
  56. pmc DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
    Kevin D Sinclair
    School of Biosciences and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, United Kingdom
    Proc Natl Acad Sci U S A 104:19351-6. 2007
    ..and fatter, elicited altered immune responses to antigenic challenge, were insulin-resistant, and had elevated blood pressure-effects that were most obvious in males...
  57. ncbi Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study
    Takayoshi Ohkubo
    Departments of Public Health, Clinical Pharmacology and Therapeutics, and Environmental Health Science, Tohoku University School of Medicine and Pharmaceutical Science, Sendai and Ohasama Hospital, Iwate, Japan
    J Hypertens 20:2183-9. 2002
    To examine the relationship between the normal nocturnal decline in blood pressure and the risk of cardiovascular mortality in individuals with and without high 24-h blood pressure values.
  58. ncbi Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism
    M Mazzali
    Division of Nephrology, University of Washington Medical Center, Seattle, USA
    Hypertension 38:1101-6. 2001
    ..Hyperuricemic rats developed elevated blood pressure after 3 weeks, whereas control rats remained normotensive...
  59. ncbi Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial
    Ramon Estruch
    Institut d Investigacions Biomèdiques August Pi Sunyer, Municipal Institut for Medical Research, University of Barcelona, and Catalan Institute of Health, Barcelona, Spain
    Ann Intern Med 145:1-11. 2006
    ..The Mediterranean diet has been shown to have beneficial effects on cardiovascular risk factors...
  60. pmc Cardiometabolic risk variables in overweight and obese children: a worldwide comparison
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:106. 2011
    ..to compare the means of glucose and lipid levels (triglycerides and HDL-cholesterol) and systolic/diastolic blood pressure values...
  61. pmc Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    Norihiro Kato
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Nat Genet 43:531-8. 2011
    We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) ..
  62. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  63. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  64. ncbi Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes
    Hermann Haller
    Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    N Engl J Med 364:907-17. 2011
    ..We investigated whether treatment with an angiotensin-receptor blocker (ARB) would delay or prevent the occurrence of microalbuminuria in patients with type 2 diabetes and normoalbuminuria...
  65. ncbi Impact of high-normal blood pressure on the risk of cardiovascular disease
    R S Vasan
    Framingham Heart Study, Mass 01702, USA
    N Engl J Med 345:1291-7. 2001
    Information is limited regarding the absolute and relative risk of cardiovascular disease in persons with high-normal blood pressure (systolic pressure of 130 to 139 mm Hg, diastolic pressure of 85 to 89 mm Hg, or both).
  66. pmc From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    Ying Wang
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 106:226-31. 2009
    ..We conducted a genome-wide association study of systolic and diastolic blood pressure (SBP and DBP) in Amish subjects and found strong association signals with common variants in a serine/..
  67. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ..We sought genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the ..
  68. pmc Long-term exposure to traffic-related air pollution associated with blood pressure and self-reported hypertension in a Danish cohort
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health Perspect 120:418-24. 2012
    Short-term exposure to air pollution has been associated with changes in blood pressure (BP) and emergency department visits for hypertension, but little is known about the effects of long-term exposure to traffic-related air pollution on ..
  69. pmc Effect of vitamin D supplementation on blood pressure in blacks
    John P Forman
    Renal Division and Kidney Clinical Research Institute, Brigham and Women s Hospital, 41 Ave Louis Pasteur, Suite 120, Boston, MA 02115, USA
    Hypertension 61:779-85. 2013
    ..There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks...
  70. ncbi Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials
    Feng J He
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
    BMJ 346:f1325. 2013
    To determine the effects of longer term modest salt reduction on blood pressure, hormones, and lipids.
  71. ncbi Relations of serum uric acid to longitudinal blood pressure tracking and hypertension incidence
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 45:28-33. 2005
    ..We investigated the relationship of serum UA to hypertension incidence and blood pressure (BP) progression in 3329 Framingham Study participants (mean age 48.7 years; 55...
  72. ncbi Predictors of long-term progression in the early manifest glaucoma trial
    M Cristina Leske
    Department of Preventive Medicine, Stony Brook University Medical Center, Stony Brook, New York 11794 8036, USA
    Ophthalmology 114:1965-72. 2007
    ..To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split)...
  73. ncbi Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis
    Tazeen H Jafar
    Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 139:244-52. 2003
    Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and urine protein excretion and slow the progression of chronic kidney disease.
  74. ncbi Determinants of accelerated progression of arterial stiffness in normotensive subjects and in treated hypertensive subjects over a 6-year period
    Athanase Benetos
    Centre d Investigations Préventives et Cliniques, Paris, France
    Circulation 105:1202-7. 2002
    ..The aim of the present longitudinal study was to compare the progression of aortic stiffness over a 6-year period in treated hypertensive subjects and normotensive subjects, and to evaluate the determinants of this progression...
  75. ncbi Blood pressure and inflammation in apparently healthy men
    C U Chae
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 38:399-403. 2001
    ..In a cross-sectional study involving 508 apparently healthy men, we studied the association between blood pressure and baseline plasma concentrations of 2 inflammatory markers, intercellular adhesion molecule-1 (sICAM-1) and ..
  76. ncbi Comparison of the novel angiotensin II receptor blocker azilsartan medoxomil vs valsartan by ambulatory blood pressure monitoring
    Domenic Sica
    Section of Clinical Pharmacology and Hypertension, Virginia Commonwealth University, Richmond, VA 23298 0160, USA
    J Clin Hypertens (Greenwich) 13:467-72. 2011
    ..with primary hypertension in a randomized, double-blind, multicenter study using ambulatory and clinic blood pressure (BP) measurements...
  77. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  78. pmc Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension
    Sandosh Padmanabhan
    Institute of Cardiovascular and Medical Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    PLoS Genet 6:e1001177. 2010
    ..The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk...
  79. ncbi Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function
    Brit Rentzsch
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hypertension 52:967-73. 2008
    ..Mean arterial blood pressure was reduced in SHRSP-ACE2 compared to SHRSP rats, and the vasoconstrictive response to intraarterial ..
  80. ncbi 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
    ..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
  81. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..The objective of this investigation was to determine whether aPWV is associated with total and cardiovascular (CV) mortality and CV events in a community-dwelling sample of older adults...
  82. ncbi Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice
    F E Rey
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, MI 48202-2689, USA
    Circ Res 89:408-14. 2001
    ..kg(-1). d(-1)), or Ang II+scramb-tat intraperitoneally in C57Bl/6 mice and measured systolic blood pressure (SBP) on days 0, 3, 5, and 7 of infusion...
  83. ncbi Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
    Rod Jackson
    Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Lancet 365:434-41. 2005
    In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels...
  84. ncbi Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension
    William B White
    Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology Center, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3940, USA
    Hypertension 57:413-20. 2011
    ..medoxomil (olmesartan) 40 mg, in a randomized, double-blind, placebo-controlled trial using ambulatory blood pressure (BP) monitoring and clinic BP measurements...
  85. ncbi Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension
    Carine M Boustany
    Graduate Center for Nutritional Sciences, Rm 521b, Charles T Wethington Bldg, Univ of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Regul Integr Comp Physiol 287:R943-9. 2004
    ..05). Mean arterial blood pressure was increased in OP rats (LF: 97 +/- 2; OR: 97 +/- 2; OP: 105 +/- 1 mmHg; P < 0.05)...
  86. ncbi Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    Aimin Xu
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Clin Chem 52:405-13. 2006
    ..Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed...
  87. ncbi The sympathetic control of blood pressure
    Patrice G Guyenet
    Department of Pharmacology, Health Sciences Center, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nat Rev Neurosci 7:335-46. 2006
    Hypertension - the chronic elevation of blood pressure - is a major human health problem...
  88. pmc H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among African Americans
    Jamie M Zoellner
    Department of Human Nutrition, Foods and Exercise, Virginia Tech, 1981 Kraft Drive 0913, Blacksburg, VA 24061, USA
    Int J Behav Nutr Phys Act 8:59. 2011
    ..This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes.
  89. ncbi A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly
    Lindon M H Wing
    School of Medicine, Flinders University, Adelaide, Australia
    N Engl J Med 348:583-92. 2003
    ..been postulated that agents that inhibit the renin-angiotensin system confer benefit beyond the reduction of blood pressure alone...
  90. ncbi Brain angiotensin peptides regulate sympathetic tone and blood pressure
    Alain G Dupont
    Department of Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
    J Hypertens 28:1599-610. 2010
    ..Angiotensin III and Angiotensin IV increase blood pressure via brain AT1 receptor stimulation...
  91. pmc Trends in utilization of lipid- and blood pressure-lowering agents and goal attainment among the U.S. diabetic population, 1999-2008
    Andreas Kuznik
    Pfizer Inc, New York, New York, USA
    Cardiovasc Diabetol 10:31. 2011
    ..59 mmol/L (100 mg/dL) and a blood pressure (BP) target of <130/80 mmHg...
  92. ncbi The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature
    R R Huxley
    Division of Public Health and Primary Health Care, Institute of Health Sciences, Oxford, UK
    J Hypertens 18:815-31. 2000
    To conduct a systematic review in order to (i) summarize the relationship between birthweight and blood pressure, following numerous publications in the last 3 years, (ii) assess whether other measures of size at birth are related to ..
  93. ncbi Blood pressure control in Italy: results of recent surveys on hypertension
    Massimo Volpe
    Division of Cardiology, II Faculty of Medicine, University of Rome La Sapienza, Sant Andrea Hospital, Rome, Italy
    J Hypertens 25:1491-8. 2007
    b>Blood pressure (BP) control is reported to be poor in hypertensive patients worldwide.
  94. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
    ..But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo...
  95. ncbi Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Villarroel 170, E 08036 Barcelona, Spain
    Hypertension 53:466-72. 2009
    Ambulatory blood pressure (BP) monitoring has become useful in the diagnosis and management of hypertensive individuals...
  96. pmc Lead exposure and cardiovascular disease--a systematic review
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:472-82. 2007
    ..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations...
  97. pmc Role of the WNK-activated SPAK kinase in regulating blood pressure
    Fatema H Rafiqi
    University of Dundee, Scotland, UK
    EMBO Mol Med 2:63-75. 2010
    ..To define the importance of this pathway in regulating blood pressure, we generated knock-in mice in which SPAK cannot be activated by WNKs...
  98. ncbi Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial
    Patricia J Elmer
    Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Ann Intern Med 144:485-95. 2006
    The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure.
  99. ncbi Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials
    Seamus P Whelton
    Tulane University, New Orleans, Louisiana 70112, USA
    Ann Intern Med 136:493-503. 2002
    Physical activity has been associated with reduced blood pressure in observational epidemiologic studies and individual clinical trials...
  100. ncbi Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study
    Eamon Dolan
    The ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Hypertension 47:365-70. 2006
    We hypothesized that the dynamic relation between diastolic and systolic blood pressure over 24 hours provides a measure of arterial stiffness and might, therefore, predict cardiovascular mortality over and above pulse pressure...
  101. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible...

Research Grants78

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..tetraplegia represent a model of sympathetic denervation characterized by relative bradycardia and low resting blood pressure. It is unknown whether OSA confers increased cardiovascular disease risk in these individuals, although the ..
  2. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..We have identified that chromogranin A (Chga)-derived peptide, catestatin (CST), lowers blood pressure (BP) and heart rate (HR) by inhibiting release of catecholamines...
  3. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..Veterans meeting the 7th Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) recommendation of arterial pressure <140/90 mmHg...
  4. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Metabolic syndrome components (blood pressure, lipids, glucose, anthropometrics), the prevalence of mood disorders, medical history, and health behaviors ..
  5. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..These findings were not the result of either the reduction of blood pressure since triple therapy (A/I + T2) did not normalize QO2/TNa nor did the increase in GFR that accompanies AII ..
  6. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..b>Blood pressure (BP) will be recorded continuously over 24hrs and cardiac sympathetic activity will be assessed by heart rate ..
  7. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..evidence supports a J- or U-shaped association between alcohol consumption and heart attack and/or high blood pressure. As such, while light-to-moderate drinking has been associated with protection from heart disease, heavy ..
  8. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Aim #4: Over a 4 h period, we will monitor peripheral arterial blood pressure and heart rate in anesthetized endotoxinemic mice treated with vehicle control or R-100 administered 1 h after ..
  9. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..The contribution of the C1 neurons to blood pressure stabilization, including during hypoxia, is well established, thanks in part to our work...
  10. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..out show reduced ability to absorb water, and genetic variations of human UT are directly linked to abnormal blood pressure. These results indicate that UT plays an important role in kidney physiology and in regulating blood pressure...
  11. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..5 mg/kg/day, a dose determined by telemetry to have no effect on blood pressure in db/db mice...
  12. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..with a number of metabolic and cardiovascular disease risk factors including insulin resistance, high blood pressure and dysregulation of lipid and glucose metabolism...
  13. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..by applicant): Metabolic syndrome (Metsyn) is a condition of coexisting abnormalities in glucose, lipid, blood pressure, and body fat homeostasis, that affects more than half of U.S. adults 55 years and older...
  14. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..Mutations in either WNK1 or WNK4 cause pseudohypoaldosteronism type II (PHA II), a form of high blood pressure caused by mutation of a single gene...
  15. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..While the role of vascular CGRP receptors is well recognized, the role of nervous system CGRP receptors in blood pressure regulation remains unclear...
  16. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..CAD risk factors include high blood pressure, high cholesterol and diabetes...
  17. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure. JSK Therapeutics (JSKT) has designed a class of diazeniumdiolate prodrugs that release NO upon interaction ..
  18. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..and the development of hypertension, suggesting a critical role for PGE2 in the maintenance of Na balance and blood pressure. In addition, salt-sensitive hypertension is associated with and linked to deficiencies in renal PGE2 ..
  19. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    ..BK through activation of the kallikrein/kinin system and BK2 receptor prevents fibrosis and decreases blood pressure in cardiovascular and renal disease (3)...
  20. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..ion transport underlies essential kidney functions, such as the regulation of extracellular volume and blood pressure and acid-base regulation...
  21. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..pleiotropic effects on both serum OC and metabolic risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin ..
  22. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..Recently, our laboratory identified a novel HTN gene, STK39, from a genome-wide association of baseline blood pressure (BP) in the Old Order Amish, a genetically homogeneous founder population...
  23. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..fat deposition and down regulation of endothelial nitric oxide - all of which plausibly contribute to elevated blood pressure (BP)and vascular and pressure- sensitive target organ injury, weight gain, dyslipidemia, and glucose ..
  24. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..There are two primary control points. Blood vessels near the brain surface maintain blood pressure in a relatively constant range according to the physiological requirements...
  25. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Aldosterone acts on the distal nephron and collecting duct to increase Na reabsorption and blood pressure. Results from two recent clinical studies (RALES and EPHESUS) demonstrated that aldosterone blockade reduced ..
  26. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..Small trails further suggest that EA can lower elevated blood pressure. Studies conducted in the last two grant cycles have evaluated supra-spinal mechanisms underlying EA's ..
  27. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..report on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure. Respiratory rate will derive from ECG readings in combination with EPG and chest motion...
  28. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory volume (FEV1), and BMI...
  29. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..agonists and antagonists that excessive circulating levels of aldo act through MR of the brain to elevate the blood pressure. Inhibition of MR in brains of Dahl Salt Sensitive hypertensive (SS) rats also mitigates their hypertension, ..
  30. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..respiratory physiology will be assessed to determine toxicity of the compounds, and in the case of NO donors blood pressure will also be monitored...
  31. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..wall is a common denominator of the atherogenic response, with elevated levels of blood cholesterol, high blood pressure, diabetes, and smoking recognized as primary risk factors...
  32. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..development and evaluation the intrathoracic pressure regulator (ITPR), intended to increase circulation and blood pressure clinically significant states of hypotension, including cardiac arrest and septic shock...
  33. The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
    Iris Z Jaffe; Fiscal Year: 2013
    ..acts by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor, to regulate blood pressure (bp)...
  34. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..5. Generate apparatus for heart rate and blood pressure measurements in the rat to determine the impact of the vestibule-sympathetic reflex during changes in head ..
  35. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..Physiological studies will be performed to assess GFR, blood pressure, and proteinuria, Western blot, immunofluorescence, genomic analysis will be used to evaluate the complex ..
  36. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..Secondary outcomes will include postpartum glucose levels, blood pressure, depression, dietary fat intake, total calories and PA...
  37. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  38. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  39. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..provided by applicant): Preeclampsia (PE) is a serious complication of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  40. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  41. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  42. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  43. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..that included demographics, psychosocial inventories, medical history, anthropometry, resting and ambulatory blood pressure, phlebotomy and 24-hour urine collection, ECG, echocardiography, and pulmonary function...
  44. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..LTD) of parasympathetic nervous system activity (PNSA) could ultimately lead to persistent increases in blood pressure and heart rate abnormalities...
  45. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..R-100 has no effect on systemic blood pressure in normotensive control rats nor in monocrotaline-induced PAH in rats, but is effective as a selective ..
  46. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..vessels and the kidney;will promote an inflammatory response and T cell activation, which further increases blood pressure. To test this hypothesis, we will cross mice heterozygotic for elastin deficiency (Eln mice) with RAG-1-/- ..
  47. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..Huntington's and Parkinson's Disease, and muscular diseases such as heart disease, high blood pressure, and uterine problems, all arise from molecular motors gone awry...
  48. Interactions of the RAAS and a Western Diet on Insulin Metabolic Actions
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..with an AT1R blocker or a mineralocortiod receptor in doses determined by telemetry to have no effect on blood pressure in mice...
  49. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..2) Determine if these Interventions reduce the severity of sleep disordered breathing and lower diurnal blood pressure. This research is innovative because it may identify novel targets and interventions to be used with CPAP that ..
  50. Genetic &Functional Analyses of Hypertension Susceptibility Genes
    YEN PEI CHRISTY CHANG; Fiscal Year: 2013
    ..Variants that play a role in determining blood pressure (BP) and HTN susceptibility have been uncovered by recent genome-wide association studies (GWAS), but the ..
  51. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..Secondary outcomes are changes in percent body fat, body mass index, waist-to-hip ratio, fasting glucose, blood pressure, plasma lipids, activity, and diet...
  52. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..functioning that ordinarily is a component of aging without resorting to chemical prescriptions that can alter blood pressure or other invasive techniques and devices that erode and interrupt natural love-making activities as practices ..
  53. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..Secondary outcomes include blood pressure, blood cholesterol, fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl ..
  54. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..3. Finally, the hypothesis that arterial KCNQ channels play an important role in vasoconstrictor actions and blood pressure regulation will be tested by measuring in vivo effects of selective KCNQ channel activators and blockers on ..
  55. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..Lung concentrations of R-503 will be correlated with outcome measures, so as to construct a PD profile. ..
  56. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Despite improvements in the past 20 years in glycemic and blood pressure control, and the introduction of 'renoprotective'drugs such as renin-angiotensin system blockers, the incidence of ..
  57. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..Multiple physiologic variables (such as core temperature, blood pressure, and heart rate) will be collected by chronic catheterization or telemetry...
  58. The Prevalence of Blood Pressure Abnormalities among Veterans with SCI
    Jill Wecht; Fiscal Year: 2009
    ..Diminished autonomic cardiovascular control following SCI can result in abnormal blood pressure, blood flow and heart rate, the degree of which may or may not be related to the level and completeness of SCI ..
  59. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..a higher prevalence of obesity and lower dietary potassium intake compared to Caucasians (these factors affect blood pressure), a stronger emphasis on lifestyle modification is justified...
  60. CATECHOLAMINES AND SEROTONIN IN BLOOD PRESSURE CONTROL
    Curt Freed; Fiscal Year: 1991
    Serotonin and the catecholamines are known to play a role in the regulation of blood pressure. Serotonin agonists, alpha-2 receptor agonists and dopamine agonists have all been shown to lower blood in hypertensive animals...
  61. WEARABLE SENSOR FOR CONTINUOUS NONINVASIVE MONITORING OF PULSE PRESSURE
    Sridhar Madala; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Wearable Sensor for Continuous Noninvasive Monitoring of Pulse Pressure Blood pressure and pulse pressure are among the most commonly measured parameters to assess cardiovascular function...
  62. Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors
    Celeste Shawler; Fiscal Year: 2010
    ..strength, perceived control, and the quality of the relationship of older mothers and their adult daughters on blood pressure self management behaviors and health related quality of life...
  63. Chicago Endothelial Function Study
    Louise C Hawkley; Fiscal Year: 2010
    _' High blood pressure is a strong, modifiable, independent risk factor for cardiovascular and renal disease, and was a primary or contributing cause of 11% of U.S. deaths in 2003 (American Heart Association, 2006)...
  64. CONTROL OF VASCULAR TONE BY CONTINGENT CNS STIMULATION
    Barry Dworkin; Fiscal Year: 2006
    ..by the applicant): These multi-disciplinary studies target the long-sought physiological link between blood pressure variability and blood pressure regulation...
  65. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    ..Moreover, normotensive African Americans exhibit exaggerated blood pressure responses to exercise, as well as to various laboratory pressor stimuli (e.g...
  66. GENETICS OF BLOOD PRESSURE CONTROL IN MEXICAN AMERICANS
    Larry Atwood; Fiscal Year: 2000
    The long term objective of this research is to understand the genetic basis of blood pressure regulation, and consequently, its effects on hypertension in Mexican Americans...
  67. Childhood Origins for Cardiac Structure and Function
    Shumei S Sun; Fiscal Year: 2012
    ..Analyses of the Fels Longitudinal Study (FLS) data set have shown that elevated blood pressure in childhood tracks into adulthood with fidelity and that elevated blood pressure in childhood, even within ..
  68. RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASE
    Gary V Desir; Fiscal Year: 2010
    ..in renalase, a newly discovered enzyme that is made in the kidney, is secreted in blood, and regulates blood pressure and cardiac function...
  69. Genotypes, Haplotypes, and Blood Pressure Change from Childhood to Adulthood
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ..While hypertension is found in <10% in adults 20 - 34 years of age, it develops over a period of years, and blood pressure levels in children and adolescents are correlated with levels in adults...
  70. Relationships between Skin Pigmentation, Vitamin D and Blood Pressure
    FLOJAUNE GRIFFIN; Fiscal Year: 2009
    ..on serum 25- hydroxycholecalciferol (vitamin D) levels, and, in turn, ascertain their association with blood pressure among women as they age...
  71. Mechanisms of the Relaxation Response in Elderly Hypertensives
    Jeffery A Dusek; Fiscal Year: 2010
    Systolic Hypertension is a disorder which is characterized by significant elevations in systolic blood pressure in association with normal diastolic blood pressure...
  72. Mechanisms of Meditation in Hypertension in Blacks
    Robert Schneider; Fiscal Year: 2010
    ..Previous randomized controlled trials in African American populations with high blood pressure conducted by the Center team have demonstrated that stress reduction intervention with the Transcendental ..
  73. CALCIUM INTAKE, METABOLISM & GESTATIONAL BLOOD PRESSURE
    Cynthia Morris; Fiscal Year: 1990
    ..dietary calcium intake and disturbances in maternal calcium metabolism may be associated with an increases in blood pressure during late gestation...