Genomes and Genes
Summary: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications254 found, 100 shown here
- The impact of the coronary collateral circulation on mortality: a meta-analysisPascal Meier
The Heart Hospital, University College London Hospitals, Cardiology, London, UK
Eur Heart J 33:614-21. 2012The coronary collateral circulation as an alternative source of blood supply has shown benefits regarding several clinical endpoints in patients with myocardial infarction (MI) such as infarct size and left ventricular remodelling...
- Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesisXuming Dai
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Rd, CB 7545, Chapel Hill, NC 27599, USA
Circ Res 106:1870-81. 2010The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology.
- Genetic architecture underlying variation in extent and remodeling of the collateral circulationShiliang Wang
Department of Cell and Molecular Physiology and the McAllister Heart Institute, University of North Carolina at Chapel Hill, NC 27599 7545, USA
Circ Res 107:558-68. 2010..Evidence suggests similar large differences exist among healthy humans...
- Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collateralsJ Waltenberger
Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany
Circulation 102:185-90. 2000..Thus far, it has not been possible to identify differences in individual responses to VEGF-A stimulation because of the lack of an ex vivo assay...
- Time course of arteriogenesis following femoral artery occlusion in the rabbitI E Hoefer
Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Benekestr 2, D 61231, Bad Nauheim, Germany
Cardiovasc Res 49:609-17. 2001..We examined the time course of arteriogenesis (collateral artery growth) after femoral artery ligation and the effect of monocyte chemoattractant protein-1 (MCP-1)...
- Venous collateral circulation of the extracranial cerebrospinal outflow routesPaolo Zamboni
Vascular Diseases Center, University of Ferrara, Ferrara, Italy
Curr Neurovasc Res 6:204-12. 2009..We review the complex gross and radiological anatomy of collateral circulation found activated by the means of EchoColor-Doppler and selective venography in the event of CCSVI, focusing ..
- Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implicationsJoshua K Meisner
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
Microcirculation 17:583-99. 2010..We propose that an improved understanding of how arteriogenesis functions as a system can reveal individual BMC populations and functions that can be targeted for overcoming particular impairments in collateral vessel development...
- Natural killer cells and CD4+ T-cells modulate collateral artery developmentV van Weel
Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 27:2310-8. 2007The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease...
- Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of strokeHua Zhang
Department of Cell and Molecular Physiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
J Cereb Blood Flow Metab 30:923-34. 2010..Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown...
- Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimbM Arras
Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
J Clin Invest 101:40-50. 1998..8 ml/min/100 mmHg vs. 45+/-6.8 ml/min/100 mmHg; P < 0.05) as compared with untreated animals after 7 d of occlusion. These results indicate that monocyte activation plays a major role in angiogenesis and collateral artery growth...
- Stimulation of collateral artery growth: travelling further down the road to clinical applicationS H Schirmer
Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Heart 95:191-7. 2009..Future directions in the translation from bench to bedside and potential new approaches to the stimulation of vascular growth are discussed...
- Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?Kerstin Wustmann
Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
Circulation 107:2213-20. 2003..Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease...
- Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurementsPascal Meier
Department of Cardiology, University Hospital, CH 3010 Bern, Switzerland
Circulation 116:975-83. 2007The prognostic relevance of the collateral circulation is still controversial...
- The range of adaptation by collateral vessels after femoral artery occlusionInka Eitenmüller
Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
Circ Res 99:656-62. 2006..Increased FSS activates the Ras-ERK-, the Rho-, and the NO- (but not the Akt-) pathway enabling collateral artery growth...
- Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limbFrederic Pipp
Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, D 61231 Germany
Arterioscler Thromb Vasc Biol 24:1664-8. 2004..Therefore, we studied the influence of FSS on arteriogenesis in a new model with extremely high levels of collateral flow and FSS in pig and rabbit hind limbs...
- Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2Matthias Heil
Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
Circ Res 94:671-7. 2004..In conclusion, our results demonstrate that the CCR2 signaling pathway is essential for efficient collateral artery growth...
- A critical review of clinical arteriogenesis researchNiels van Royen
Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Am Coll Cardiol 55:17-25. 2009..growth factors, degrading enzymes and survival factors that are required for the development of a mature collateral circulation. Experimental stimulation of arteriogenesis is feasible but to date a relatively low number of clinical ..
- Where there is blood, there is a way: unusual collateral vessels in superior and inferior vena cava obstructionSangita Kapur
Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45267 0761, USA
Radiographics 30:67-78. 2010..An understanding of these unusual collateral pathways is essential in a patient with caval occlusion who presents with signs and symptoms of a right-to-left shunt or has unusual enhancing lesions in the liver...
- Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humansStephan H Schirmer
Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
J Am Coll Cardiol 53:2141-7. 2009Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans.
- Actin-binding rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesisKerstin Troidl
Max Planck Institute for Heart and Lung Research, Parkstr 1, D 61231 Bad Nauheim, Germany
Arterioscler Thromb Vasc Biol 29:2093-101. 2009Arteriogenesis, the development of a collateral circulation, is important for tissue survival but remains functionally defective because of early normalization of fluid shear stress (FSS)...
- Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: quantification with MRILars Grosse-Wortmann
The Labatt Family Heart Center and the Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
Circ Cardiovasc Imaging 2:219-25. 2009..We aimed to quantify APC flow after bidirectional cavopulmonary connections and Fontan completions, using phase-contrast MRI, and to identify risk factors for the development of APCs...
- Effects of exercise training on coronary collateralization and control of collateral resistanceCristine L Heaps
Michael E DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
J Appl Physiol (1985) 111:587-98. 2011..The innate collateral circulation of the normal human heart is typically minimal and considerable variability occurs in extent of ..
- Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart diseaseJon R Resar
Division of Cardiology, The Johns Hopkins University School of Medicine, Blalock 524, 600 North Wolfe St, Baltimore, MD 21287, USA
Chest 128:787-91. 2005..Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development...
- Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosisStephan H Schirmer
Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
Eur Heart J 33:1223-31. 2012..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
- Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in miceVincent van Weel
Gaubius Laboratory TNO Biomedical Research, Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 26:1383-90. 2006..Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis...
- Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocolP Zamboni
Vascular Diseases Center, University of Ferrara, Ferrara, Italy
Int Angiol 30:571-97. 2011..47 to k=0.80), while within-rater reproducibility in trained operators was k=0.75. Finally, the consensus document proposes a reporting standard of Duplex measurements, and future research to answer areas of uncertainty...
- Impaired coronary collateral vessel development in patients with metabolic syndromeHasan Turhan
Department of Cardiology, Inonu University, Malatya and Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
Coron Artery Dis 16:281-5. 2005..and evidence of myocardial ischemia suggest that some other factors may affect the development of collateral circulation. In the present study we aimed to evaluate coronary collateral circulation in patients with metabolic ..
- Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery diseasePo Chao Hsu
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC
BMC Nephrol 13:98. 2012Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events...
- Formation and maturation of the native cerebral collateral circulationDan Chalothorn
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
J Mol Cell Cardiol 49:251-9. 2010The native (pre-existing) collateral circulation minimizes tissue injury if obstructive vascular disease develops...
- Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusionW D Ito
Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
Circ Res 80:829-37. 1997..01; peripheral conductance, 119.3 +/- 22.37 versus 45.4 +/- 6.80 mL/min per 100 mm Hg; P < .05). These results suggest that activation of monocytes plays an important role in collateral growth as well as in capillary sprouting...
- Determinants of preformed collateral vessels in the human heart without coronary artery diseaseStefano F de Marchi
Department of Cardiology, University Hospital, Bern, Switzerland
Cardiology 118:198-206. 2011Coronary collaterals protect myocardium jeopardized by coronary artery disease (CAD). Promotion of collateral circulation is desirable before myocardial damage occurs...
- A potential evidence to explain the reason behind the devastating prognosis of coronary artery disease in uraemic patients: renal insufficiency is associated with poor coronary collateral vessel developmentMurat Sezer
Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, 34390, Capa Istanbul, Turkey
Int J Cardiol 115:366-72. 2007The potential of individuals to develop coronary collateral circulation is often neglected but is of potential major importance in myocardial vulnerability...
- Effect of coronary collaterals on microvascular obstruction as assessed by magnetic resonance imaging in patients with acute ST-elevation myocardial infarction treated by primary coronary interventionSteffen Desch
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
Am J Cardiol 104:1204-9. 2009..5% vs 12.2%, p = 0.07). In conclusion, well-developed collaterals before reperfusion by PCI in patients with STEMI are associated with a protective effect on coronary microcirculation...
- Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissuesJames E Faber
Department of Physiology, McAllister Heart Institute, University of North Carolina, Chapel Hill, 27599 7545, USA
Arterioscler Thromb Vasc Biol 31:1748-56. 2011..Whether collateral rarefaction and impaired remodeling contribute to this is unknown. We quantified the number and diameter of native collaterals and their remodeling in 3-, 16-, 24-, and 31-month-old mice...
- Retrograde chronic total occlusion intervention: tips and tricksEugene B Wu
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, People s Republic of China
Catheter Cardiovasc Interv 72:806-14. 2008..We hope that many others would find rewardingly successful cases of retrograde approach CTO percutaneous coronary intervention, as in our experience...
- Collateralization and the response to obstruction of epicardial coronary arteriesM H Tayebjee
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
QJM 97:259-72. 2004..However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual ..
- Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia modelMasanori Fujita
Department of Medical Engineering, National Defense Medical College, Saitama, Japan
Wound Repair Regen 15:58-65. 2007..These results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/CH-LA/IO4-heparin induces angiogenesis and possibly collateral circulation in db/db mice and the ischemic limbs of rats.
- Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destructionJi Song
Dept of Biomedical Engineering, Univ of Virginia, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
Am J Physiol Heart Circ Physiol 287:H2754-61. 2004..We conclude that ultrasonic microbubble destruction can be tailored to stimulate an arteriogenesis response that restores hyperemia blood flow to skeletal muscle in a rat model of arterial occlusion...
- Congenital absence of the internal carotid artery: case reports and review of the collateral circulationC A Given
Department of Neuroradiology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA
AJNR Am J Neuroradiol 22:1953-9. 2001..Recognition of this anomaly has important implications during planned carotid or transsphenoidal surgery, in thromboembolic disease, and in the surveillance and detection of associated cerebral aneurysms...
- Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemiaS Takeshita
Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
Circulation 98:1261-3. 1998..The purpose of this study was to determine in vivo the extent to which vasomotor responses of collateral microvessels are altered after VEGF treatment...
- Carotid artery occlusion and collateral circulation in C57Black/6J mice detected by synchrotron radiation microangiographyMasahiro Tamaki
Department of Neurosurgery, Kobe University Graduate School of Medicine
Kobe J Med Sci 52:111-8. 2006..We could successfully visualize the cerebral vasculature of normal mice and carotid artery occluded mice in an in vivo study. Microangiography can demonstrate the development of vasculature and the blood flow dynamics in mice...
- Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusionMatthew A Ziegler
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Microcirculation 17:3-20. 2010....
- [Pathophysiology of portal hypertension, what's new?]Moon Young Kim
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
Korean J Gastroenterol 56:129-34. 2010..by contributing to increased intrahepatic resistance, hyperdynamic circulation and the expansion of the collateral circulation. PHT is also importantly characterized by changes in vascular structure; termed vascular remodeling, which ..
- Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2Renhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Nat Med 9:604-13. 2003..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases...
- Coronary collateral flow in response to endurance exercise trainingRainer Zbinden
Department of Cardiology, University Hospital, Bern, Switzerland
Eur J Cardiovasc Prev Rehabil 14:250-7. 2007....
- Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)D Scholz
Department of Experimental Cardiology, Max Planck Institute, Bad Nauheim, Germany
Virchows Arch 436:257-70. 2000..We conclude that the process of arteriogenesis, which leads to the positive remodeling of an arteriole into an artery up to 12 times its original size, can be modified by modulators of inflammation...
- Different strategies of retrograde approach in coronary angioplasty for chronic total occlusionShigeru Saito
Division of Cardiology and Catheterization Laboratories, Heart Center of ShonanKamakura General Hospital, Kamakura City, Japan
Catheter Cardiovasc Interv 71:8-19. 2008..Retrograde approach through the collateral channels has been recently proposed and has the potential to improve the success rate of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) lesions of the coronary arteries...
- Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic ratsMarc Mejias
Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, CIBERehd, Barcelona, Spain
Hepatology 49:1245-56. 2009..Notably, beneficial effects of sorafenib against tissue damage and inflammation were also observed in splanchnic organs...
- Territorial arterial spin labeling in the assessment of collateral circulation: comparison with digital subtraction angiographySoke Miang Chng
Department of Neuroradiology, National Neuroscience Institute, Singapore
Stroke 39:3248-54. 2008b>Collateral circulation plays a vital role in patients with steno-occlusive disease, in particular for predicting stroke outcome...
- Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetesRaffaele Marfella
Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
Diabetes 53:2383-91. 2004..001). Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia...
- Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary interventionP Elsman
Department of Cardiology, Isala Klinieken, locatie Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands
Eur Heart J 25:854-8. 2004....
- Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbitsN van Royen
Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
Cardiovasc Res 57:178-85. 2003..Additionally, we aimed to determine the effects of locally applied MCP-1 on systemic serum lipid levels as well as on atherosclerosis...
- Collateral blood vessels in acute ischaemic stroke: a potential therapeutic targetAshfaq Shuaib
Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
Lancet Neurol 10:909-21. 2011..Several interventions that might augment collateral blood flow are being investigated...
- Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogsJohn G Kingma
Faculty of Medicine, Laval University, Cite Universitaire, Sainte Foy, QC, Canada G1K 7P4
Cardiovasc Res 89:384-91. 2011..We examined in isoflurane-anaesthetized dogs whether an intact cardiac nervous system was necessary to mediate rIPC protection against ischaemic injury...
- Noninvasive quantification of systemic-to-pulmonary collateral flow: a major source of inefficiency in patients with superior cavopulmonary connectionsKevin K Whitehead
Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Circ Cardiovasc Imaging 2:405-11. 2009....
- Coronary collaterals improve prognosis in patients with ischemic heart diseaseJakub J Regieli
Department of Cardiology, University Medical Center Utrecht, The Netherlands
Int J Cardiol 132:257-62. 2009..We examined the effects of coronary collateral circulation on cardiovascular outcomes, with an emphasis on clinical prognostic value and on a putative role of IHD ..
- Importance of collateral circulation in coronary heart diseaseColin Berry
Department of Medicine, Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
Eur Heart J 28:278-91. 2007..We endeavoured to review the methods for coronary artery collateral assessment, the predictors and clinical importance of collateral blood flow, and the potential for therapeutic augmentation of collateral anastomoses...
- Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulationV van Weel
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Ann Vasc Surg 22:582-97. 2008..Better understanding of the highly complex molecular and cellular mechanisms of vascular growth may yet lead to meaningful clinical applications...
- Retrograde percutaneous recanalization of chronic total occlusion of the coronary arteries: procedural outcomes and predictors of success in contemporary practiceSudhir Rathore
Department of Cardiology, Toyohashi Heart Center, 21 1 Gobudori, Oyama cho, Toyohashi, Japan
Circ Cardiovasc Interv 2:124-32. 2009..We investigated the safety and efficacy of retrograde approaches used for percutaneous recanalization of CTO in a consecutive series of patients...
- Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)E E Buschmann
Franz Volhard Klinik, Department for Cardiology, Helios Klinikum Buch, Berlin, Germany
Eur J Clin Invest 39:866-75. 2009..The goal of this trial was to investigate the effect of external counterpulsation (ECP) on coronary collateral artery growth...
- Collateral circulation in symptomatic intracranial atherosclerosisDavid S Liebeskind
Department of Neurology, UCLA Stroke Center, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
J Cereb Blood Flow Metab 31:1293-301. 2011b>Collateral circulation in intracranial atherosclerosis has never been systematically characterized. We investigated collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease...
- G-CSF induced arteriogenesis in humans: molecular insights into a randomized controlled trialPascal Meier
The Heart Hospital, University College London Hospitals, London, UK
Curr Vasc Pharmacol 11:38-46. 2013..The aim of this study was to evaluate potential mechanisms, especially the involvement of arteriogenesis-relevant genes...
- Repair of aortic coarctation using temporary ascending to descending aortic bypass in children with poor collateral circulationJan T Christenson
Department of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
Cardiol Young 14:39-45. 2004..Preoperative evaluation showing the absence of collateral circulation is valuable in order to introduce protective actions...
- Assessment of collateral circulation to the hand prior to radial artery harvestJoseph Habib
Vascular Laboratory, The OSU Heart and Vascular Center and the Division of Vascular Diseases and Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
Vasc Med 17:352-61. 2012Assessment of collateral circulation to the hand is required prior to invasive procedures or harvesting of the radial artery (RA). A modified Allen's test (MAT) is commonly used to assess palmar arch collaterals...
- Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic ratsC C Chan
Taipei Veterans General Hospital, Taipei, Taiwan
Eur J Clin Invest 34:290-6. 2004..This study investigated the collateral vascular responses to ET-1, the receptors in mediation and the regulation of ET-1 action by nitric oxide and prostaglandin in cirrhotic rats with a relatively low degree of portal-systemic shunting...
- Progression of myocardial infarction in a collateral flow deficient speciesT Miura
Second Department of Internal Medicine, Sapporo Medical College, Japan
Jpn Heart J 30:695-708. 1989..Unlike in the dog heart, the infarct of the rabbit heart first appears in the midmyocardium and then progresses towards both the endocardium and epicardium...
- Effect of diabetes mellitus on formation of coronary collateral vesselsA Abaci
Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey
Circulation 99:2239-42. 1999..The nature of this variability is not well known. Likewise, it remains unclear whether diabetes mellitus (DM) has any effect on CCVs. The aim of this study was to evaluate the effect of DM on CCVs...
- The human coronary collateral circulationChristian Seiler
Heart 89:1352-7. 2003
- The human coronary collateral circulationChristian Seiler
Cardiology, University Hospital, Bern, Switzerland
Eur J Clin Invest 40:465-76. 2010..Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival...
- Coronary collateral growth by external counterpulsation: a randomised controlled trialSteffen Gloekler
University Hospital, CH 3010 Bern, Switzerland
Heart 96:202-7. 2010..Objective To test the hypothesis that ECP augments collateral function during a 1 min coronary balloon occlusion...
- Why is coronary collateral growth impaired in type II diabetes and the metabolic syndrome?Petra Rocic
Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, AL 36688, United States
Vascul Pharmacol 57:179-86. 2012....
- The collateral circulation of the heartPascal Meier
The Heart Hospital London, University College London Hospitals UCLH, London, UK
BMC Med 11:143. 2013..The collateral circulation can be assessed by different methods; the gold standard involves intracoronary pressure measurements...
- Collateral circulation on perfusion-computed tomography-source images predicts the response to stroke intravenous thrombolysisA I Calleja
Stroke Unit, Department of Neurology, Hospital Clinico Universitario, Valladolid, Spain
Eur J Neurol 20:795-802. 2013..We described a regional LMC scale on PCT-SI and hypothesized that a higher collateral score would predict a better response to intravenous (iv) thrombolysis...
- Collateral circulation in internal carotid artery occlusion. A study by duplex scan and magnetic resonance angiographyC Macchi
Department of Cardiovascular Medicine, Don Gnocchi Foundation, University of Florence, Florence, Italy
Minerva Cardioangiol 50:695-700. 2002..In this paper symptoms of patients with ICA occlusion have been related to the development of collateral circulation, different types of developed collateral circulation have been assessed, and the degree of sensitivity and ..
- Collateral pathways in thoracic central venous obstruction: three-dimensional display using direct spiral computed tomography venographyHyo Cheol Kim
Department of Radiology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
J Comput Assist Tomogr 28:24-33. 2004....
- Collateral pathways in superior vena caval obstruction as seen on CTM Cihangiroglu
Department of Radiology, The University of Chicago, IL 60637, USA
J Comput Assist Tomogr 25:1-8. 2001..Many collateral patterns found in this series could not be classified with the existent classification scheme...
- Relation between fragmented QRS and collateral circulation in patients with chronic total occlusion without prior myocardial infarctionHasan Kadi
Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
Anadolu Kardiyol Derg 11:300-4. 2011..We hypothesized that presence of fQRS on ECG may be related with poorly-grown collateral coronary circulation (CCC) in patients with chronic total coronary occlusion (CTO) without prior MI...
- Poor coronary collateral vessel development in patients with mild to moderate renal insufficiencyShuang Lun Xie
Department of Cardiology, Sun Yat sen Memorial Hospital of Sun Yat sen University, West Yanjiang Road 107, Guangzhou, People s Republic of China
Clin Res Cardiol 100:227-33. 2011..The aim of this study was to investigate the relationship between mild to moderate renal insufficiency and coronary collateral development in patients with chronic total coronary artery occlusion...
- The sword of Damocles: an illustrative example of the life-saving effect of the collateral circulationPascal Meier
University College London Hospital, 16 18 Westmoreland Street, London, United Kingdom
J Invasive Cardiol 23:E47-8. 2011..be it percutaneously or surgically; thus, people may question a significant benefit of the coronary collateral circulation. However, the presented 61-year-old male patient demonstrates an unambiguous situation of a life-saving ..
- Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia modelKonstantinos Katsanos
Department of Radiology, Medical School, University of Patras, Patras, Greece
J Vasc Surg 49:1000-12. 2009..Based on these observations, we hypothesized that thrombin may promote the development of mature functional blood vessels...
- Electrocardiographic changes of ST-elevation myocardial infarction in patients with complete occlusion of the left main trunk without collateral circulation: differential diagnosis and clinical considerationsMiquel Fiol
Hospital Son Espases, Palma de Mallorca, Spain
J Electrocardiol 45:487-90. 2012..We present a series of 7 patients with total left main trunk occlusion without collateral circulation showing ST-elevation myocardial infarction pattern...
- Quantification of collateral aortopulmonary flow in patients subsequent to construction of bidirectional cavopulmonary shuntsRyo Inuzuka
The Department of Pediatric Cardiology and Pediatric Cardiothoracic Surgery, Chiba Children s Hospital, Chiba, Japan
Cardiol Young 18:485-93. 2008..We sought to provide a new method for quantifying collateral aortopulmonary flow in patients subsequent to construction of a bidirectional cavopulmonary shunt, and to clarify the clinical advantages of the new method...
- Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery diseaseSong ming Chen
Department of Cardiology, First Affiliated Hospital, Shantou, Guangdong, China
Coron Artery Dis 19:173-9. 2008..It could play an important role in modulating collateral development...
- Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulationDursun Aras
Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
Coron Artery Dis 17:159-63. 2006..sought to determine the relationship between serum lipoprotein (a) levels and angiographically visible coronary collateral circulation and to evaluate whether lipoprotein (a) exerts any effect on vascular endothelial cell growth factor.
- Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic miceRadia Tamarat
Institut National de la Santé et de la Recherche Médicale U541, Hopital Lariboisiere, Institut fédératif de recherche Circulation Paris 7, Universite Paris 7 Denis Diderot, 75475 Paris Cedex 10, France
Proc Natl Acad Sci U S A 100:8555-60. 2003..This effect is probably mediated by restoration of matrix degradation processes that are disturbed as a result of AGE accumulation...
- The extent of the collateral circulation influences the postprandial increase in portal pressure in patients with cirrhosisAgustin Albillos
Hospital Universitario Ramon y Cajal, Universidad de Alcala, Madrid, Spain
Gut 56:259-64. 2007..In cirrhosis, repeated flares of portal pressure and collateral blood flow provoked by postprandial hyperaemia may contribute to variceal dilation and rupture...
- Preliminary results of Tc-99m ECD SPECT to evaluate cerebral collateral circulation during balloon test occlusionYuka Yamamoto
Department of Radiology, Faculty of Medicine, Kagawa Medical University, Japan
Clin Nucl Med 27:633-7. 2002..of regional cerebral blood flow using Tc-99m L,L-ethyl cysteinate dimer (Tc-99m ECD) SPECT to evaluate cerebral collateral circulation during balloon test occlusion (BTO) of the internal carotid artery and vertebral artery (VA).
- Absence of myocardial ischemia during sudden controlled occlusion of coronary arteries in patients with well-developed collateral vesselsK Miwa
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
Coron Artery Dis 10:459-63. 1999....
- Indocyanine green (ICG) temporary clipping test to assess collateral circulation before venous sacrificePaolo Ferroli
Neurosurgery, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy
World Neurosurg 75:122-5. 2011..At present, no method exists to predict whether such sacrifice will be accommodated by the presence of collateral venous drainage. We show a simple technique to examine cerebral venous blood flow using indocyanine green videoangiography...
- Characterization and treatment of systemic venous to pulmonary venous collaterals seen after the Fontan operationHisashi Sugiyama
Department of Pediatrics and Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, School of Medicine, Toronto, Ontario, Canada
Cardiol Young 13:424-30. 2003..To determine the anatomical characteristics of systemic venous collaterals formed after the Fontan operation, and the efficacy of a transcatheter strategy for management...
- The power of collateral circulation: a case of asymptomatic chronic total occlusion of the left main coronary arteryTajinderpal Saraon
Division of Cardiology, Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY 11212 USA
J Invasive Cardiol 24:E196-8. 2012..This case demonstrates the power of collateral circulation in protecting the patient from symptoms and death despite total occlusion of the left main coronary artery ..
- Extrahepatic collateral artery supply to the tumor thrombi of hepatocellular carcinoma invading inferior vena cava: the prevalence and determinant factorsIn Joon Lee
Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
J Vasc Interv Radiol 20:22-9. 2009..To retrospectively evaluate the prevalence of extrahepatic collateral artery supply to tumor thrombi of hepatocellular carcinomas (HCCs) invading the inferior vena cava (IVC) and to assess the determining factors...
- Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery diseaseTsung Hsien Lin
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
Clin Chim Acta 411:1688-93. 2010..This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD)...
- Strain-dependent variation in collateral circulatory function in mouse hindlimbDan Chalothorn
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
Physiol Genomics 42:469-79. 2010The extent (density and diameter) of the native (preexisting) collateral circulation in healthy tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are important determinants of ischemic injury...
- [Collateral circulation of the left colon: historic considerations and actual clinical significance]K Renner
Chirurgische Abteilung, Donauspital am SMZ Ost, Vienna, Austria
Chirurg 74:575-8. 2003..The arterial communication between the superior and inferior mesenteric arteries is important in surgery of the colon and aorta...
- Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesisMakoto Sumi
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Arterioscler Thromb Vasc Biol 27:813-8. 2007..Here, we investigated the effect of HDL on differentiation of endothelial progenitor cells and angiogenesis in murine ischemic hindlimb model...
- Prognostic significance of coronary collaterals in patients with coronary heart disease having percutaneous transluminal coronary angioplastyJeroen Koerselman
Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
Am J Cardiol 96:390-4. 2005..In patients with ischemic heart disease, the angiographic presence of coronary collaterals may mark an unfavorable prognosis, particularly in relatively high-risk patients...
- Impact of coronary collaterals on outcome following percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)J Dawn Abbott
Division of Cardiology, Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
Am J Cardiol 96:676-80. 2005Coronary collateral circulation is beneficial in patients with coronary artery disease, but controversy still exists regarding the association between angiographic collaterals and outcome after percutaneous coronary intervention (PCI)...
- Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversyR Zbinden
Department of Cardiology, University Hospital Bern, Bern, Switzerland
Heart 91:1289-93. 2005..To determine the influence of diabetes mellitus on coronary collateral flow by accurate means of collateral flow measurement in a large population with variable degrees of coronary artery disease...
- Effect of coronary collaterals on long-term prognosis in patients undergoing primary angioplasty for acute ST-elevation myocardial infarctionSteffen Desch
Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
Am J Cardiol 106:605-11. 2010..In conclusion, the presence of a well-developed collateral network before mechanical reperfusion in patients with STEMI is associated with improved long-term survival and lower major adverse cardiovascular event rates...
- Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral functionGerald S Werner
Clinic for Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany
Circulation 110:1940-5. 2004..Despite extensive animal experimental evidence, there are few data on the relation of growth factors and collateral function in humans...
- Surgical Indirect Revascularization For Symptomatic Intracranial Aterial StenosisNestor Gonzalez; Fiscal Year: 2013..demanding, avoiding temporary occlusion of cerebral vessels, and allowing gradual development of collateral circulation where the brain demands it, deterring early hyper perfusion and hemorrhage...
- Targeting the Pial Collateral Circulation for Mitigation of Cerebral IschemiaJames E Faber; Fiscal Year: 2013..This project will identify the primary driver gene that controls formation of the native collateral circulation and is responsible for its wide variation...
- Maintenance and Rarefaction of the Native Collateral CirculationJames E Faber; Fiscal Year: 2013....
- Reactive Oxygen Species in Coronary Collateral GrowthWilliam M Chilian; Fiscal Year: 2013..the cell type or types in the heart responsible for redox signaling in the growth of the coronary collateral circulation in response to repetitive ischemia...
- White Matter Protection in Acute Ischemic StrokeChia Yi Kuan; Fiscal Year: 2012..Yet, WM has a disproportionally small blood supply and less collateral circulation, making it highly susceptible to hypoxic-ischemic insults...
- Collateral Circulation in Acute Ischemic StrokeDAVID SIGMUND LIEBESKIND; Fiscal Year: 2010b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
- FACTORS THAT REGULATE COLLATERAL PERFUSIONDavid Harrison; Fiscal Year: 1993..During the next 5 years, we plan to extend our studies of the collateral circulation. Specifically, we plan studies to determine what factors modulate the opening of partially developed and ..
- Effects of Diabetes Mellitus on the Development of Collateral CriculationDivya Gupta; Fiscal Year: 2009..This interaction and its involvement in collateral circulation is relevant to the health of the millions of diabetic patients in the world...
- ANTI INFARCTION EFFECTS IN THE DENERVATED HEARTPATRICIA GWIRTZ; Fiscal Year: 1993..chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as does surgical sympathectomy...
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
- EFFECT OF HYPERTENSION AND HYPERTROPHY ON LV ISCHEMIAPETER ROAN; Fiscal Year: 1980..compared between groups of animals since the variability in infarct size arising from differences in collateral circulation is reduced. Infarct size can then be expressed as percent LAD bed at risk...
- Stem cell-based therapy in heart failure: aging effectsMohamed Gaballa; Fiscal Year: 2003Induction of collateral circulation after myocardial infarction (MI) is impaired in aging. However, the mechanisms of this impairment are unclear...
- FUNCTION AND GROWTH OF CORONARY COLLATERAL VESSELSJohn Longhurst; Fiscal Year: 1990..The purpose of the proposed research is to further develop a model of the coronary collateral circulation and to examine various mechanisms that may enhance or retard development of this circulation and capillary ..
- Therapeutic angiogenesis to treat ischemic disordersKeith Webster; Fiscal Year: 2002..or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate collateral circulation, and improve tissue function...
- CIRCULATORY AND METABOLIC ADAPTATIONS IN ISCHEMIC LIMBSMartin Kushmerick; Fiscal Year: 1991..We will document by angiography the time course and extent of collateral circulation development, and assess its functional capacity by direct blood flow measurements...
- HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEAAndrew Levy; Fiscal Year: 2003Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
- INTRACORONARY DELIVERY OF PLASMID DNA TO CARDIAC TISSUESHans Herweijer; Fiscal Year: 2001..development is an important adaptive response of the ischemic heart in this situation, but often the collateral circulation is inadequate and results in severe angina pectoris despite maximal medical therapy...
- NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGEMarsha Moses; Fiscal Year: 2002..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
- MRI OF COLLATERAL DEVELOPMENT IN THE HEARTMichael Jerosch Herold; Fiscal Year: 2002DESCRIPTION (Adapted from Applicants Abstract): In ischemic heart disease the presence and extent of collateral circulation can prevent myocardial infarction, or at least limit the damage and reduce the size of infarcts...
- MRI OF CORONARY COLLATERALSJustin Pearlman; Fiscal Year: 2000..Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia...
- DETERMINANTS OF CORONARY COLLATERAL DEVELOPMENTCOLIN BLOOR; Fiscal Year: 1999DESCRIPTION: Survival of the ischemic heart is dependent on the growth of the collateral circulation. However, collateral development is frequently not sufficient to fully meet the blood supply needs of the compromised myocardium...
- EPC mediated Neovascularization in Ischemic MyocardiumPavan Atluri; Fiscal Year: 2006..Endothelial progenitor cell (EPC) mediated neo-vascularization may provide a means to increase collateral circulation in ischemic myocardium, thereby improving cardiac function...
- MECHANISMS OF CARDIOVASCULAR REACTION TO INJURYCHARLES MURRY; Fiscal Year: 2007..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
- ESTROGEN EFFECT ON COLLATERAL GROWTH AND FUNCTIONKathryn Lamping; Fiscal Year: 2001....
- MECHANISMS OF MYOCARDIAL ISCHEMIC INJURY IN DIABETESJudy R Kersten; Fiscal Year: 2010..abstract_text> ..
- Endothelial Nitric Oxide Synthase & Portal HypertensionVijay Shah; Fiscal Year: 2002..abstract_text> ..
- Molecular Mechanisms of Portal HypertensionVijay Shah; Fiscal Year: 2007..abstract_text> ..
- Hibernating Myocardium and Sudden Cardiac DeathJOHN CANTY; Fiscal Year: 2008..Our long-term objective is to develop better approaches to identify patients with CAD who are most likely to benefit from primary prevention of SCD with placement of an ICD. [unreadable] [unreadable]..
- Inhibition of TNF in Patients with Alcoholic HepatitisVijay Shah; Fiscal Year: 2005..abstract_text> ..
- Microvascular Regulation During Intestinal AbsorptionHAROLD G BOHLEN; Fiscal Year: 2010..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
- MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUSHAROLD BOHLEN; Fiscal Year: 2002..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
- Metabolic Adaptation and Functional Recovery of Hibernating MyocardiumJohn M Canty; Fiscal Year: 2010..Our long-term objective is to use this research to develop new strategies to reverse myocardial dysfunction in patients with ischemic cardiomyoapthy which will reduce death and disability from heart failure and sudden death. ..
- Failure of FasL Mediated Pathways in Tumor AngiogenesisVijay Shah; Fiscal Year: 2006..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
- REG OF NITRIC OXIDE PRODUCT IN THE HEPATIC CIRCULATIONVijay Shah; Fiscal Year: 2002..Defining the mechanisms that regulate nitric oxide production in SEC may lead to therapeutic options whereby NO activity may be pharmacologically or genetically modulated and benefit patients with cirrhosis and portal hypertension. ..
- Lipoproteins, HIV, and Antiretroviral Therapy in SMARTDaniel Duprez; Fiscal Year: 2008..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
- Study of Carotid Occlusion and Neurocognition (RECON)RANDOLPH MARSHALL; Fiscal Year: 2009....
- Hypoxia-Inducible Factor 1 and Oxygen HomeostasisGregg Semenza; Fiscal Year: 2009....
- The Role of Tenascin in Neointimal FormationPrediman Shah; Fiscal Year: 2009..Aim 3. TN deficiency promotes neointimal formation after vascular injury. Aim 4. TN deficiency per se is sufficient for neointimal formation. ..
- THE CARNITINE TRANSPORTER IN HUMAN DISEASENicola Longo; Fiscal Year: 2010....
- Development of Arterial Spin Labeling for Clinical ApplicationsEric Wong; Fiscal Year: 2009..The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived. ..
- CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NOCristine L Heaps; Fiscal Year: 2010....
- Anaplerotic therapy in Propionic AcidemiaNicola Longo; Fiscal Year: 2008..This approach, if effective, could be extended to a number of other diseases, including other organic acidemias and mitochondrial disorders. [unreadable] [unreadable] [unreadable]..
- Inhomogeneous Sympathetic Innervation in IHDJAMES FALLAVOLLITA; Fiscal Year: 2008..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
- EXPRESSION OF HUMAN ERYTHROPOIETIN GENEGregg Semenza; Fiscal Year: 2002..abstract_text> ..
- NON-INVASIVE EVALUATION OF ICP AND HEMODYNAMICSDavid Newell; Fiscal Year: 2002..We then propose to test this method for accuracy of continuous recording of ICP under ICU conditions. ..
- Arterial Spin Labeling for fMRIEric Wong; Fiscal Year: 2002....
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2002..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
- Expression and function of PIGF in cardiomyocytesRONALD TORRY; Fiscal Year: 2003..Collectively, these data may provide support for PIGF-mediated therapeutic approaches to facilitate coronary microvascular growth and/or reduce the cardiomyocyte loss associated with ischemic heart disease. ..
- CARDIAC VALVE CALCIFICATIONEmile Mohler; Fiscal Year: 2003..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
- Genetic Analysis of Vascular AgingSteven Miller; Fiscal Year: 2003..abstract_text> ..
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2004..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
- Pyruvate-enhanced cardiopulmonary resuscitationRobert Mallet; Fiscal Year: 2004....
- CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTIONSanjiv Kaul; Fiscal Year: 2004..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
- CORONARY MICROCIRCULATION-ACUTE MYOCARDIAL INFARCTIONSanjiv Kaul; Fiscal Year: 2004..The study aims will be to test the 4 above-mentioned hypotheses in patients with suspected AMI. ..
- The Chemokine System in Collateral Artery FormationPAULA SHIREMAN; Fiscal Year: 2006..These investigations, under the guidance of my mentors and coupled with the courses and seminars in this proposal will substantially broaden my scientific experience to allow me to become an independent scientist. ..
- Mechanisms By Which Endothelium Cells Sense Changes in HemodynamicsBauer Sumpio; Fiscal Year: 2007..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
- Invasive Assessment of the Coronary MicrocirculationWilliam Fearon; Fiscal Year: 2008..abstract_text> ..
- Homocysteine/Hypertension & Vascular Lesion FormationPeter Lin; Fiscal Year: 2008..abstract_text> ..
- NO production and S-nitrosylation in liver vasculatureYasuko Iwakiri; Fiscal Year: 2008..The School of Medicine has pledged protected time for the candidate during this further training period prior to functioning as an independent investigator. ..
- MATRIXINS AND THEIR INHIBITORS IN ANGIOGENESISQING XIANG SANG; Fiscal Year: 2002..The role of each collagen-degrading matrixin in each step of angiogenesis in vitro will be assessed through intervention by the synthetic matrixin inhibitors. ..