collateral circulation

Summary

Summary: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.

Top Publications

  1. ncbi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
  2. pmc Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis
    Xuming Dai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Rd, CB 7545, Chapel Hill, NC 27599, USA
    Circ Res 106:1870-81. 2010
  3. pmc Genetic architecture underlying variation in extent and remodeling of the collateral circulation
    Shiliang Wang
    Department of Cell and Molecular Physiology and the McAllister Heart Institute, University of North Carolina at Chapel Hill, NC 27599 7545, USA
    Circ Res 107:558-68. 2010
  4. ncbi Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals
    J Waltenberger
    Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany
    Circulation 102:185-90. 2000
  5. ncbi Time course of arteriogenesis following femoral artery occlusion in the rabbit
    I E Hoefer
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Benekestr 2, D 61231, Bad Nauheim, Germany
    Cardiovasc Res 49:609-17. 2001
  6. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
  7. pmc Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications
    Joshua K Meisner
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Microcirculation 17:583-99. 2010
  8. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
  9. pmc Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke
    Hua Zhang
    Department of Cell and Molecular Physiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    J Cereb Blood Flow Metab 30:923-34. 2010
  10. pmc Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb
    M Arras
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
    J Clin Invest 101:40-50. 1998

Detail Information

Publications254 found, 100 shown here

  1. ncbi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
    The coronary collateral circulation as an alternative source of blood supply has shown benefits regarding several clinical endpoints in patients with myocardial infarction (MI) such as infarct size and left ventricular remodelling...
  2. pmc Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis
    Xuming Dai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Rd, CB 7545, Chapel Hill, NC 27599, USA
    Circ Res 106:1870-81. 2010
    The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology.
  3. pmc Genetic architecture underlying variation in extent and remodeling of the collateral circulation
    Shiliang Wang
    Department of Cell and Molecular Physiology and the McAllister Heart Institute, University of North Carolina at Chapel Hill, NC 27599 7545, USA
    Circ Res 107:558-68. 2010
    ..Evidence suggests similar large differences exist among healthy humans...
  4. ncbi Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals
    J Waltenberger
    Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany
    Circulation 102:185-90. 2000
    ..Thus far, it has not been possible to identify differences in individual responses to VEGF-A stimulation because of the lack of an ex vivo assay...
  5. ncbi Time course of arteriogenesis following femoral artery occlusion in the rabbit
    I E Hoefer
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Benekestr 2, D 61231, Bad Nauheim, Germany
    Cardiovasc Res 49:609-17. 2001
    ..We examined the time course of arteriogenesis (collateral artery growth) after femoral artery ligation and the effect of monocyte chemoattractant protein-1 (MCP-1)...
  6. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
    ..We review the complex gross and radiological anatomy of collateral circulation found activated by the means of EchoColor-Doppler and selective venography in the event of CCSVI, focusing ..
  7. pmc Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications
    Joshua K Meisner
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Microcirculation 17:583-99. 2010
    ..We propose that an improved understanding of how arteriogenesis functions as a system can reveal individual BMC populations and functions that can be targeted for overcoming particular impairments in collateral vessel development...
  8. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease...
  9. pmc Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke
    Hua Zhang
    Department of Cell and Molecular Physiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    J Cereb Blood Flow Metab 30:923-34. 2010
    ..Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown...
  10. pmc Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb
    M Arras
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, D 61231 Bad Nauheim, Germany
    J Clin Invest 101:40-50. 1998
    ..8 ml/min/100 mmHg vs. 45+/-6.8 ml/min/100 mmHg; P < 0.05) as compared with untreated animals after 7 d of occlusion. These results indicate that monocyte activation plays a major role in angiogenesis and collateral artery growth...
  11. ncbi Stimulation of collateral artery growth: travelling further down the road to clinical application
    S H Schirmer
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Heart 95:191-7. 2009
    ..Future directions in the translation from bench to bedside and potential new approaches to the stimulation of vascular growth are discussed...
  12. ncbi Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    Kerstin Wustmann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 107:2213-20. 2003
    ..Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease...
  13. ncbi Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements
    Pascal Meier
    Department of Cardiology, University Hospital, CH 3010 Bern, Switzerland
    Circulation 116:975-83. 2007
    The prognostic relevance of the collateral circulation is still controversial...
  14. ncbi The range of adaptation by collateral vessels after femoral artery occlusion
    Inka Eitenmüller
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Circ Res 99:656-62. 2006
    ..Increased FSS activates the Ras-ERK-, the Rho-, and the NO- (but not the Akt-) pathway enabling collateral artery growth...
  15. ncbi Elevated fluid shear stress enhances postocclusive collateral artery growth and gene expression in the pig hind limb
    Frederic Pipp
    Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, D 61231 Germany
    Arterioscler Thromb Vasc Biol 24:1664-8. 2004
    ..Therefore, we studied the influence of FSS on arteriogenesis in a new model with extremely high levels of collateral flow and FSS in pig and rabbit hind limbs...
  16. ncbi Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2
    Matthias Heil
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 94:671-7. 2004
    ..In conclusion, our results demonstrate that the CCR2 signaling pathway is essential for efficient collateral artery growth...
  17. ncbi A critical review of clinical arteriogenesis research
    Niels van Royen
    Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:17-25. 2009
    ..growth factors, degrading enzymes and survival factors that are required for the development of a mature collateral circulation. Experimental stimulation of arteriogenesis is feasible but to date a relatively low number of clinical ..
  18. ncbi Where there is blood, there is a way: unusual collateral vessels in superior and inferior vena cava obstruction
    Sangita Kapur
    Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45267 0761, USA
    Radiographics 30:67-78. 2010
    ..An understanding of these unusual collateral pathways is essential in a patient with caval occlusion who presents with signs and symptoms of a right-to-left shunt or has unusual enhancing lesions in the liver...
  19. ncbi Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Coll Cardiol 53:2141-7. 2009
    Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans.
  20. ncbi Actin-binding rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesis
    Kerstin Troidl
    Max Planck Institute for Heart and Lung Research, Parkstr 1, D 61231 Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 29:2093-101. 2009
    Arteriogenesis, the development of a collateral circulation, is important for tissue survival but remains functionally defective because of early normalization of fluid shear stress (FSS)...
  21. ncbi Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: quantification with MRI
    Lars Grosse-Wortmann
    The Labatt Family Heart Center and the Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Circ Cardiovasc Imaging 2:219-25. 2009
    ..We aimed to quantify APC flow after bidirectional cavopulmonary connections and Fontan completions, using phase-contrast MRI, and to identify risk factors for the development of APCs...
  22. pmc Effects of exercise training on coronary collateralization and control of collateral resistance
    Cristine L Heaps
    Michael E DeBakey Institute for Comparative Cardiovascular Science and Biomedical Devices, Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
    J Appl Physiol (1985) 111:587-98. 2011
    ..The innate collateral circulation of the normal human heart is typically minimal and considerable variability occurs in extent of ..
  23. ncbi Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease
    Jon R Resar
    Division of Cardiology, The Johns Hopkins University School of Medicine, Blalock 524, 600 North Wolfe St, Baltimore, MD 21287, USA
    Chest 128:787-91. 2005
    ..Hypoxia inducible factor 1 (HIF-1), a transcriptional activator that functions as a master regulator of oxygen homeostasis, is one possible genetic factor that could play an important role in modulating collateral development...
  24. ncbi Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis
    Stephan H Schirmer
    Klinik für Innere Medizin III Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Kirrberger Strase, Homburg Saar, Germany
    Eur Heart J 33:1223-31. 2012
    ..Collateral arteries protect tissue from ischaemia. Heart rate correlates with vascular events in patients with arterial obstructive disease. Here, we tested the effect of heart-rate reduction (HRR) on collateral artery growth...
  25. ncbi Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice
    Vincent van Weel
    Gaubius Laboratory TNO Biomedical Research, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:1383-90. 2006
    ..Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis...
  26. ncbi Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 30:571-97. 2011
    ..47 to k=0.80), while within-rater reproducibility in trained operators was k=0.75. Finally, the consensus document proposes a reporting standard of Duplex measurements, and future research to answer areas of uncertainty...
  27. ncbi Impaired coronary collateral vessel development in patients with metabolic syndrome
    Hasan Turhan
    Department of Cardiology, Inonu University, Malatya and Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Coron Artery Dis 16:281-5. 2005
    ..and evidence of myocardial ischemia suggest that some other factors may affect the development of collateral circulation. In the present study we aimed to evaluate coronary collateral circulation in patients with metabolic ..
  28. pmc Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease
    Po Chao Hsu
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC
    BMC Nephrol 13:98. 2012
    Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events...
  29. pmc Formation and maturation of the native cerebral collateral circulation
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
    J Mol Cell Cardiol 49:251-9. 2010
    The native (pre-existing) collateral circulation minimizes tissue injury if obstructive vascular disease develops...
  30. ncbi Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion
    W D Ito
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 80:829-37. 1997
    ..01; peripheral conductance, 119.3 +/- 22.37 versus 45.4 +/- 6.80 mL/min per 100 mm Hg; P < .05). These results suggest that activation of monocytes plays an important role in collateral growth as well as in capillary sprouting...
  31. ncbi Determinants of preformed collateral vessels in the human heart without coronary artery disease
    Stefano F de Marchi
    Department of Cardiology, University Hospital, Bern, Switzerland
    Cardiology 118:198-206. 2011
    Coronary collaterals protect myocardium jeopardized by coronary artery disease (CAD). Promotion of collateral circulation is desirable before myocardial damage occurs...
  32. ncbi A potential evidence to explain the reason behind the devastating prognosis of coronary artery disease in uraemic patients: renal insufficiency is associated with poor coronary collateral vessel development
    Murat Sezer
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, 34390, Capa Istanbul, Turkey
    Int J Cardiol 115:366-72. 2007
    The potential of individuals to develop coronary collateral circulation is often neglected but is of potential major importance in myocardial vulnerability...
  33. ncbi Effect of coronary collaterals on microvascular obstruction as assessed by magnetic resonance imaging in patients with acute ST-elevation myocardial infarction treated by primary coronary intervention
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 104:1204-9. 2009
    ..5% vs 12.2%, p = 0.07). In conclusion, well-developed collaterals before reperfusion by PCI in patients with STEMI are associated with a protective effect on coronary microcirculation...
  34. pmc Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues
    James E Faber
    Department of Physiology, McAllister Heart Institute, University of North Carolina, Chapel Hill, 27599 7545, USA
    Arterioscler Thromb Vasc Biol 31:1748-56. 2011
    ..Whether collateral rarefaction and impaired remodeling contribute to this is unknown. We quantified the number and diameter of native collaterals and their remodeling in 3-, 16-, 24-, and 31-month-old mice...
  35. ncbi Retrograde chronic total occlusion intervention: tips and tricks
    Eugene B Wu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Catheter Cardiovasc Interv 72:806-14. 2008
    ..We hope that many others would find rewardingly successful cases of retrograde approach CTO percutaneous coronary intervention, as in our experience...
  36. ncbi Collateralization and the response to obstruction of epicardial coronary arteries
    M H Tayebjee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    QJM 97:259-72. 2004
    ..However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual ..
  37. ncbi Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia model
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    Wound Repair Regen 15:58-65. 2007
    ..These results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/CH-LA/IO4-heparin induces angiogenesis and possibly collateral circulation in db/db mice and the ischemic limbs of rats.
  38. ncbi Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction
    Ji Song
    Dept of Biomedical Engineering, Univ of Virginia, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 287:H2754-61. 2004
    ..We conclude that ultrasonic microbubble destruction can be tailored to stimulate an arteriogenesis response that restores hyperemia blood flow to skeletal muscle in a rat model of arterial occlusion...
  39. ncbi Congenital absence of the internal carotid artery: case reports and review of the collateral circulation
    C A Given
    Department of Neuroradiology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA
    AJNR Am J Neuroradiol 22:1953-9. 2001
    ..Recognition of this anomaly has important implications during planned carotid or transsphenoidal surgery, in thromboembolic disease, and in the surveillance and detection of associated cerebral aneurysms...
  40. ncbi Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia
    S Takeshita
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Circulation 98:1261-3. 1998
    ..The purpose of this study was to determine in vivo the extent to which vasomotor responses of collateral microvessels are altered after VEGF treatment...
  41. ncbi Carotid artery occlusion and collateral circulation in C57Black/6J mice detected by synchrotron radiation microangiography
    Masahiro Tamaki
    Department of Neurosurgery, Kobe University Graduate School of Medicine
    Kobe J Med Sci 52:111-8. 2006
    ..We could successfully visualize the cerebral vasculature of normal mice and carotid artery occluded mice in an in vivo study. Microangiography can demonstrate the development of vasculature and the blood flow dynamics in mice...
  42. pmc Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusion
    Matthew A Ziegler
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Microcirculation 17:3-20. 2010
    ....
  43. ncbi [Pathophysiology of portal hypertension, what's new?]
    Moon Young Kim
    Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
    Korean J Gastroenterol 56:129-34. 2010
    ..by contributing to increased intrahepatic resistance, hyperdynamic circulation and the expansion of the collateral circulation. PHT is also importantly characterized by changes in vascular structure; termed vascular remodeling, which ..
  44. ncbi Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Nat Med 9:604-13. 2003
    ..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases...
  45. ncbi Coronary collateral flow in response to endurance exercise training
    Rainer Zbinden
    Department of Cardiology, University Hospital, Bern, Switzerland
    Eur J Cardiovasc Prev Rehabil 14:250-7. 2007
    ....
  46. ncbi Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)
    D Scholz
    Department of Experimental Cardiology, Max Planck Institute, Bad Nauheim, Germany
    Virchows Arch 436:257-70. 2000
    ..We conclude that the process of arteriogenesis, which leads to the positive remodeling of an arteriole into an artery up to 12 times its original size, can be modified by modulators of inflammation...
  47. ncbi Different strategies of retrograde approach in coronary angioplasty for chronic total occlusion
    Shigeru Saito
    Division of Cardiology and Catheterization Laboratories, Heart Center of ShonanKamakura General Hospital, Kamakura City, Japan
    Catheter Cardiovasc Interv 71:8-19. 2008
    ..Retrograde approach through the collateral channels has been recently proposed and has the potential to improve the success rate of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) lesions of the coronary arteries...
  48. ncbi Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    Marc Mejias
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, CIBERehd, Barcelona, Spain
    Hepatology 49:1245-56. 2009
    ..Notably, beneficial effects of sorafenib against tissue damage and inflammation were also observed in splanchnic organs...
  49. ncbi Territorial arterial spin labeling in the assessment of collateral circulation: comparison with digital subtraction angiography
    Soke Miang Chng
    Department of Neuroradiology, National Neuroscience Institute, Singapore
    Stroke 39:3248-54. 2008
    b>Collateral circulation plays a vital role in patients with steno-occlusive disease, in particular for predicting stroke outcome...
  50. ncbi Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Section of Pathology, Second University of Naples, Naples, Italy
    Diabetes 53:2383-91. 2004
    ..001). Diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression of myocardial angiogenesis factors during ischemia...
  51. ncbi Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention
    P Elsman
    Department of Cardiology, Isala Klinieken, locatie Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands
    Eur Heart J 25:854-8. 2004
    ....
  52. ncbi Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits
    N van Royen
    Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 57:178-85. 2003
    ..Additionally, we aimed to determine the effects of locally applied MCP-1 on systemic serum lipid levels as well as on atherosclerosis...
  53. ncbi Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet Neurol 10:909-21. 2011
    ..Several interventions that might augment collateral blood flow are being investigated...
  54. ncbi Role of the autonomic nervous system in cardioprotection by remote preconditioning in isoflurane-anaesthetized dogs
    John G Kingma
    Faculty of Medicine, Laval University, Cite Universitaire, Sainte Foy, QC, Canada G1K 7P4
    Cardiovasc Res 89:384-91. 2011
    ..We examined in isoflurane-anaesthetized dogs whether an intact cardiac nervous system was necessary to mediate rIPC protection against ischaemic injury...
  55. pmc Noninvasive quantification of systemic-to-pulmonary collateral flow: a major source of inefficiency in patients with superior cavopulmonary connections
    Kevin K Whitehead
    Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Circ Cardiovasc Imaging 2:405-11. 2009
    ....
  56. ncbi Coronary collaterals improve prognosis in patients with ischemic heart disease
    Jakub J Regieli
    Department of Cardiology, University Medical Center Utrecht, The Netherlands
    Int J Cardiol 132:257-62. 2009
    ..We examined the effects of coronary collateral circulation on cardiovascular outcomes, with an emphasis on clinical prognostic value and on a putative role of IHD ..
  57. ncbi Importance of collateral circulation in coronary heart disease
    Colin Berry
    Department of Medicine, Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
    Eur Heart J 28:278-91. 2007
    ..We endeavoured to review the methods for coronary artery collateral assessment, the predictors and clinical importance of collateral blood flow, and the potential for therapeutic augmentation of collateral anastomoses...
  58. ncbi Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation
    V van Weel
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Vasc Surg 22:582-97. 2008
    ..Better understanding of the highly complex molecular and cellular mechanisms of vascular growth may yet lead to meaningful clinical applications...
  59. ncbi Retrograde percutaneous recanalization of chronic total occlusion of the coronary arteries: procedural outcomes and predictors of success in contemporary practice
    Sudhir Rathore
    Department of Cardiology, Toyohashi Heart Center, 21 1 Gobudori, Oyama cho, Toyohashi, Japan
    Circ Cardiovasc Interv 2:124-32. 2009
    ..We investigated the safety and efficacy of retrograde approaches used for percutaneous recanalization of CTO in a consecutive series of patients...
  60. ncbi Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)
    E E Buschmann
    Franz Volhard Klinik, Department for Cardiology, Helios Klinikum Buch, Berlin, Germany
    Eur J Clin Invest 39:866-75. 2009
    ..The goal of this trial was to investigate the effect of external counterpulsation (ECP) on coronary collateral artery growth...
  61. pmc Collateral circulation in symptomatic intracranial atherosclerosis
    David S Liebeskind
    Department of Neurology, UCLA Stroke Center, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Cereb Blood Flow Metab 31:1293-301. 2011
    b>Collateral circulation in intracranial atherosclerosis has never been systematically characterized. We investigated collaterals in a multicenter trial of symptomatic intracranial atherosclerotic disease...
  62. ncbi G-CSF induced arteriogenesis in humans: molecular insights into a randomized controlled trial
    Pascal Meier
    The Heart Hospital, University College London Hospitals, London, UK
    Curr Vasc Pharmacol 11:38-46. 2013
    ..The aim of this study was to evaluate potential mechanisms, especially the involvement of arteriogenesis-relevant genes...
  63. ncbi Repair of aortic coarctation using temporary ascending to descending aortic bypass in children with poor collateral circulation
    Jan T Christenson
    Department of Cardiovascular Surgery, University Hospital of Geneva, Geneva, Switzerland
    Cardiol Young 14:39-45. 2004
    ..Preoperative evaluation showing the absence of collateral circulation is valuable in order to introduce protective actions...
  64. ncbi Assessment of collateral circulation to the hand prior to radial artery harvest
    Joseph Habib
    Vascular Laboratory, The OSU Heart and Vascular Center and the Division of Vascular Diseases and Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Vasc Med 17:352-61. 2012
    Assessment of collateral circulation to the hand is required prior to invasive procedures or harvesting of the radial artery (RA). A modified Allen's test (MAT) is commonly used to assess palmar arch collaterals...
  65. ncbi Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats
    C C Chan
    Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Clin Invest 34:290-6. 2004
    ..This study investigated the collateral vascular responses to ET-1, the receptors in mediation and the regulation of ET-1 action by nitric oxide and prostaglandin in cirrhotic rats with a relatively low degree of portal-systemic shunting...
  66. ncbi Progression of myocardial infarction in a collateral flow deficient species
    T Miura
    Second Department of Internal Medicine, Sapporo Medical College, Japan
    Jpn Heart J 30:695-708. 1989
    ..Unlike in the dog heart, the infarct of the rabbit heart first appears in the midmyocardium and then progresses towards both the endocardium and epicardium...
  67. ncbi Effect of diabetes mellitus on formation of coronary collateral vessels
    A Abaci
    Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey
    Circulation 99:2239-42. 1999
    ..The nature of this variability is not well known. Likewise, it remains unclear whether diabetes mellitus (DM) has any effect on CCVs. The aim of this study was to evaluate the effect of DM on CCVs...
  68. pmc The human coronary collateral circulation
    Christian Seiler
    Heart 89:1352-7. 2003
  69. ncbi The human coronary collateral circulation
    Christian Seiler
    Cardiology, University Hospital, Bern, Switzerland
    Eur J Clin Invest 40:465-76. 2010
    ..Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival...
  70. ncbi Coronary collateral growth by external counterpulsation: a randomised controlled trial
    Steffen Gloekler
    University Hospital, CH 3010 Bern, Switzerland
    Heart 96:202-7. 2010
    ..Objective To test the hypothesis that ECP augments collateral function during a 1 min coronary balloon occlusion...
  71. pmc Why is coronary collateral growth impaired in type II diabetes and the metabolic syndrome?
    Petra Rocic
    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, AL 36688, United States
    Vascul Pharmacol 57:179-86. 2012
    ....
  72. pmc The collateral circulation of the heart
    Pascal Meier
    The Heart Hospital London, University College London Hospitals UCLH, London, UK
    BMC Med 11:143. 2013
    ..The collateral circulation can be assessed by different methods; the gold standard involves intracoronary pressure measurements...
  73. ncbi Collateral circulation on perfusion-computed tomography-source images predicts the response to stroke intravenous thrombolysis
    A I Calleja
    Stroke Unit, Department of Neurology, Hospital Clinico Universitario, Valladolid, Spain
    Eur J Neurol 20:795-802. 2013
    ..We described a regional LMC scale on PCT-SI and hypothesized that a higher collateral score would predict a better response to intravenous (iv) thrombolysis...
  74. ncbi Collateral circulation in internal carotid artery occlusion. A study by duplex scan and magnetic resonance angiography
    C Macchi
    Department of Cardiovascular Medicine, Don Gnocchi Foundation, University of Florence, Florence, Italy
    Minerva Cardioangiol 50:695-700. 2002
    ..In this paper symptoms of patients with ICA occlusion have been related to the development of collateral circulation, different types of developed collateral circulation have been assessed, and the degree of sensitivity and ..
  75. ncbi Collateral pathways in thoracic central venous obstruction: three-dimensional display using direct spiral computed tomography venography
    Hyo Cheol Kim
    Department of Radiology, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Comput Assist Tomogr 28:24-33. 2004
    ....
  76. ncbi Collateral pathways in superior vena caval obstruction as seen on CT
    M Cihangiroglu
    Department of Radiology, The University of Chicago, IL 60637, USA
    J Comput Assist Tomogr 25:1-8. 2001
    ..Many collateral patterns found in this series could not be classified with the existent classification scheme...
  77. ncbi Relation between fragmented QRS and collateral circulation in patients with chronic total occlusion without prior myocardial infarction
    Hasan Kadi
    Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
    Anadolu Kardiyol Derg 11:300-4. 2011
    ..We hypothesized that presence of fQRS on ECG may be related with poorly-grown collateral coronary circulation (CCC) in patients with chronic total coronary occlusion (CTO) without prior MI...
  78. ncbi Poor coronary collateral vessel development in patients with mild to moderate renal insufficiency
    Shuang Lun Xie
    Department of Cardiology, Sun Yat sen Memorial Hospital of Sun Yat sen University, West Yanjiang Road 107, Guangzhou, People s Republic of China
    Clin Res Cardiol 100:227-33. 2011
    ..The aim of this study was to investigate the relationship between mild to moderate renal insufficiency and coronary collateral development in patients with chronic total coronary artery occlusion...
  79. ncbi The sword of Damocles: an illustrative example of the life-saving effect of the collateral circulation
    Pascal Meier
    University College London Hospital, 16 18 Westmoreland Street, London, United Kingdom
    J Invasive Cardiol 23:E47-8. 2011
    ..be it percutaneously or surgically; thus, people may question a significant benefit of the coronary collateral circulation. However, the presented 61-year-old male patient demonstrates an unambiguous situation of a life-saving ..
  80. ncbi Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model
    Konstantinos Katsanos
    Department of Radiology, Medical School, University of Patras, Patras, Greece
    J Vasc Surg 49:1000-12. 2009
    ..Based on these observations, we hypothesized that thrombin may promote the development of mature functional blood vessels...
  81. ncbi Electrocardiographic changes of ST-elevation myocardial infarction in patients with complete occlusion of the left main trunk without collateral circulation: differential diagnosis and clinical considerations
    Miquel Fiol
    Hospital Son Espases, Palma de Mallorca, Spain
    J Electrocardiol 45:487-90. 2012
    ..We present a series of 7 patients with total left main trunk occlusion without collateral circulation showing ST-elevation myocardial infarction pattern...
  82. ncbi Quantification of collateral aortopulmonary flow in patients subsequent to construction of bidirectional cavopulmonary shunts
    Ryo Inuzuka
    The Department of Pediatric Cardiology and Pediatric Cardiothoracic Surgery, Chiba Children s Hospital, Chiba, Japan
    Cardiol Young 18:485-93. 2008
    ..We sought to provide a new method for quantifying collateral aortopulmonary flow in patients subsequent to construction of a bidirectional cavopulmonary shunt, and to clarify the clinical advantages of the new method...
  83. ncbi Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery disease
    Song ming Chen
    Department of Cardiology, First Affiliated Hospital, Shantou, Guangdong, China
    Coron Artery Dis 19:173-9. 2008
    ..It could play an important role in modulating collateral development...
  84. ncbi Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulation
    Dursun Aras
    Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Coron Artery Dis 17:159-63. 2006
    ..sought to determine the relationship between serum lipoprotein (a) levels and angiographically visible coronary collateral circulation and to evaluate whether lipoprotein (a) exerts any effect on vascular endothelial cell growth factor.
  85. pmc Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice
    Radia Tamarat
    Institut National de la Santé et de la Recherche Médicale U541, Hopital Lariboisiere, Institut fédératif de recherche Circulation Paris 7, Universite Paris 7 Denis Diderot, 75475 Paris Cedex 10, France
    Proc Natl Acad Sci U S A 100:8555-60. 2003
    ..This effect is probably mediated by restoration of matrix degradation processes that are disturbed as a result of AGE accumulation...
  86. pmc The extent of the collateral circulation influences the postprandial increase in portal pressure in patients with cirrhosis
    Agustin Albillos
    Hospital Universitario Ramon y Cajal, Universidad de Alcala, Madrid, Spain
    Gut 56:259-64. 2007
    ..In cirrhosis, repeated flares of portal pressure and collateral blood flow provoked by postprandial hyperaemia may contribute to variceal dilation and rupture...
  87. ncbi Preliminary results of Tc-99m ECD SPECT to evaluate cerebral collateral circulation during balloon test occlusion
    Yuka Yamamoto
    Department of Radiology, Faculty of Medicine, Kagawa Medical University, Japan
    Clin Nucl Med 27:633-7. 2002
    ..of regional cerebral blood flow using Tc-99m L,L-ethyl cysteinate dimer (Tc-99m ECD) SPECT to evaluate cerebral collateral circulation during balloon test occlusion (BTO) of the internal carotid artery and vertebral artery (VA).
  88. ncbi Absence of myocardial ischemia during sudden controlled occlusion of coronary arteries in patients with well-developed collateral vessels
    K Miwa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Coron Artery Dis 10:459-63. 1999
    ....
  89. ncbi Indocyanine green (ICG) temporary clipping test to assess collateral circulation before venous sacrifice
    Paolo Ferroli
    Neurosurgery, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy
    World Neurosurg 75:122-5. 2011
    ..At present, no method exists to predict whether such sacrifice will be accommodated by the presence of collateral venous drainage. We show a simple technique to examine cerebral venous blood flow using indocyanine green videoangiography...
  90. ncbi Characterization and treatment of systemic venous to pulmonary venous collaterals seen after the Fontan operation
    Hisashi Sugiyama
    Department of Pediatrics and Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, School of Medicine, Toronto, Ontario, Canada
    Cardiol Young 13:424-30. 2003
    ..To determine the anatomical characteristics of systemic venous collaterals formed after the Fontan operation, and the efficacy of a transcatheter strategy for management...
  91. ncbi The power of collateral circulation: a case of asymptomatic chronic total occlusion of the left main coronary artery
    Tajinderpal Saraon
    Division of Cardiology, Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY 11212 USA
    J Invasive Cardiol 24:E196-8. 2012
    ..This case demonstrates the power of collateral circulation in protecting the patient from symptoms and death despite total occlusion of the left main coronary artery ..
  92. ncbi Extrahepatic collateral artery supply to the tumor thrombi of hepatocellular carcinoma invading inferior vena cava: the prevalence and determinant factors
    In Joon Lee
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    J Vasc Interv Radiol 20:22-9. 2009
    ..To retrospectively evaluate the prevalence of extrahepatic collateral artery supply to tumor thrombi of hepatocellular carcinomas (HCCs) invading the inferior vena cava (IVC) and to assess the determining factors...
  93. ncbi Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease
    Tsung Hsien Lin
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
    Clin Chim Acta 411:1688-93. 2010
    ..This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD)...
  94. pmc Strain-dependent variation in collateral circulatory function in mouse hindlimb
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
    Physiol Genomics 42:469-79. 2010
    The extent (density and diameter) of the native (preexisting) collateral circulation in healthy tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are important determinants of ischemic injury...
  95. ncbi [Collateral circulation of the left colon: historic considerations and actual clinical significance]
    K Renner
    Chirurgische Abteilung, Donauspital am SMZ Ost, Vienna, Austria
    Chirurg 74:575-8. 2003
    ..The arterial communication between the superior and inferior mesenteric arteries is important in surgery of the colon and aorta...
  96. ncbi Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis
    Makoto Sumi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 27:813-8. 2007
    ..Here, we investigated the effect of HDL on differentiation of endothelial progenitor cells and angiogenesis in murine ischemic hindlimb model...
  97. ncbi Prognostic significance of coronary collaterals in patients with coronary heart disease having percutaneous transluminal coronary angioplasty
    Jeroen Koerselman
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Am J Cardiol 96:390-4. 2005
    ..In patients with ischemic heart disease, the angiographic presence of coronary collaterals may mark an unfavorable prognosis, particularly in relatively high-risk patients...
  98. ncbi Impact of coronary collaterals on outcome following percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)
    J Dawn Abbott
    Division of Cardiology, Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
    Am J Cardiol 96:676-80. 2005
    Coronary collateral circulation is beneficial in patients with coronary artery disease, but controversy still exists regarding the association between angiographic collaterals and outcome after percutaneous coronary intervention (PCI)...
  99. pmc Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy
    R Zbinden
    Department of Cardiology, University Hospital Bern, Bern, Switzerland
    Heart 91:1289-93. 2005
    ..To determine the influence of diabetes mellitus on coronary collateral flow by accurate means of collateral flow measurement in a large population with variable degrees of coronary artery disease...
  100. ncbi Effect of coronary collaterals on long-term prognosis in patients undergoing primary angioplasty for acute ST-elevation myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 106:605-11. 2010
    ..In conclusion, the presence of a well-developed collateral network before mechanical reperfusion in patients with STEMI is associated with improved long-term survival and lower major adverse cardiovascular event rates...
  101. ncbi Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function
    Gerald S Werner
    Clinic for Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany
    Circulation 110:1940-5. 2004
    ..Despite extensive animal experimental evidence, there are few data on the relation of growth factors and collateral function in humans...

Research Grants62

  1. Surgical Indirect Revascularization For Symptomatic Intracranial Aterial Stenosis
    Nestor Gonzalez; Fiscal Year: 2013
    ..demanding, avoiding temporary occlusion of cerebral vessels, and allowing gradual development of collateral circulation where the brain demands it, deterring early hyper perfusion and hemorrhage...
  2. Targeting the Pial Collateral Circulation for Mitigation of Cerebral Ischemia
    James E Faber; Fiscal Year: 2013
    ..This project will identify the primary driver gene that controls formation of the native collateral circulation and is responsible for its wide variation...
  3. Maintenance and Rarefaction of the Native Collateral Circulation
    James E Faber; Fiscal Year: 2013
    ....
  4. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2013
    ..the cell type or types in the heart responsible for redox signaling in the growth of the coronary collateral circulation in response to repetitive ischemia...
  5. White Matter Protection in Acute Ischemic Stroke
    Chia Yi Kuan; Fiscal Year: 2012
    ..Yet, WM has a disproportionally small blood supply and less collateral circulation, making it highly susceptible to hypoxic-ischemic insults...
  6. Collateral Circulation in Acute Ischemic Stroke
    DAVID SIGMUND LIEBESKIND; Fiscal Year: 2010
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  7. FACTORS THAT REGULATE COLLATERAL PERFUSION
    David Harrison; Fiscal Year: 1993
    ..During the next 5 years, we plan to extend our studies of the collateral circulation. Specifically, we plan studies to determine what factors modulate the opening of partially developed and ..
  8. Effects of Diabetes Mellitus on the Development of Collateral Criculation
    Divya Gupta; Fiscal Year: 2009
    ..This interaction and its involvement in collateral circulation is relevant to the health of the millions of diabetic patients in the world...
  9. ANTI INFARCTION EFFECTS IN THE DENERVATED HEART
    PATRICIA GWIRTZ; Fiscal Year: 1993
    ..chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as does surgical sympathectomy...
  10. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
  11. EFFECT OF HYPERTENSION AND HYPERTROPHY ON LV ISCHEMIA
    PETER ROAN; Fiscal Year: 1980
    ..compared between groups of animals since the variability in infarct size arising from differences in collateral circulation is reduced. Infarct size can then be expressed as percent LAD bed at risk...
  12. Stem cell-based therapy in heart failure: aging effects
    Mohamed Gaballa; Fiscal Year: 2003
    Induction of collateral circulation after myocardial infarction (MI) is impaired in aging. However, the mechanisms of this impairment are unclear...
  13. FUNCTION AND GROWTH OF CORONARY COLLATERAL VESSELS
    John Longhurst; Fiscal Year: 1990
    ..The purpose of the proposed research is to further develop a model of the coronary collateral circulation and to examine various mechanisms that may enhance or retard development of this circulation and capillary ..
  14. Therapeutic angiogenesis to treat ischemic disorders
    Keith Webster; Fiscal Year: 2002
    ..or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate collateral circulation, and improve tissue function...
  15. CIRCULATORY AND METABOLIC ADAPTATIONS IN ISCHEMIC LIMBS
    Martin Kushmerick; Fiscal Year: 1991
    ..We will document by angiography the time course and extent of collateral circulation development, and assess its functional capacity by direct blood flow measurements...
  16. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2003
    Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
  17. INTRACORONARY DELIVERY OF PLASMID DNA TO CARDIAC TISSUES
    Hans Herweijer; Fiscal Year: 2001
    ..development is an important adaptive response of the ischemic heart in this situation, but often the collateral circulation is inadequate and results in severe angina pectoris despite maximal medical therapy...
  18. NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGE
    Marsha Moses; Fiscal Year: 2002
    ..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
  19. MRI OF COLLATERAL DEVELOPMENT IN THE HEART
    Michael Jerosch Herold; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicants Abstract): In ischemic heart disease the presence and extent of collateral circulation can prevent myocardial infarction, or at least limit the damage and reduce the size of infarcts...
  20. MRI OF CORONARY COLLATERALS
    Justin Pearlman; Fiscal Year: 2000
    ..Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia...
  21. DETERMINANTS OF CORONARY COLLATERAL DEVELOPMENT
    COLIN BLOOR; Fiscal Year: 1999
    DESCRIPTION: Survival of the ischemic heart is dependent on the growth of the collateral circulation. However, collateral development is frequently not sufficient to fully meet the blood supply needs of the compromised myocardium...
  22. EPC mediated Neovascularization in Ischemic Myocardium
    Pavan Atluri; Fiscal Year: 2006
    ..Endothelial progenitor cell (EPC) mediated neo-vascularization may provide a means to increase collateral circulation in ischemic myocardium, thereby improving cardiac function...
  23. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2007
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  24. ESTROGEN EFFECT ON COLLATERAL GROWTH AND FUNCTION
    Kathryn Lamping; Fiscal Year: 2001
    ....
  25. MECHANISMS OF MYOCARDIAL ISCHEMIC INJURY IN DIABETES
    Judy R Kersten; Fiscal Year: 2010
    ..abstract_text> ..
  26. Endothelial Nitric Oxide Synthase & Portal Hypertension
    Vijay Shah; Fiscal Year: 2002
    ..abstract_text> ..
  27. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  28. Hibernating Myocardium and Sudden Cardiac Death
    JOHN CANTY; Fiscal Year: 2008
    ..Our long-term objective is to develop better approaches to identify patients with CAD who are most likely to benefit from primary prevention of SCD with placement of an ICD. [unreadable] [unreadable]..
  29. Inhibition of TNF in Patients with Alcoholic Hepatitis
    Vijay Shah; Fiscal Year: 2005
    ..abstract_text> ..
  30. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  31. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  32. Metabolic Adaptation and Functional Recovery of Hibernating Myocardium
    John M Canty; Fiscal Year: 2010
    ..Our long-term objective is to use this research to develop new strategies to reverse myocardial dysfunction in patients with ischemic cardiomyoapthy which will reduce death and disability from heart failure and sudden death. ..
  33. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
  34. REG OF NITRIC OXIDE PRODUCT IN THE HEPATIC CIRCULATION
    Vijay Shah; Fiscal Year: 2002
    ..Defining the mechanisms that regulate nitric oxide production in SEC may lead to therapeutic options whereby NO activity may be pharmacologically or genetically modulated and benefit patients with cirrhosis and portal hypertension. ..
  35. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  36. Study of Carotid Occlusion and Neurocognition (RECON)
    RANDOLPH MARSHALL; Fiscal Year: 2009
    ....
  37. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  38. The Role of Tenascin in Neointimal Formation
    Prediman Shah; Fiscal Year: 2009
    ..Aim 3. TN deficiency promotes neointimal formation after vascular injury. Aim 4. TN deficiency per se is sufficient for neointimal formation. ..
  39. THE CARNITINE TRANSPORTER IN HUMAN DISEASE
    Nicola Longo; Fiscal Year: 2010
    ....
  40. Development of Arterial Spin Labeling for Clinical Applications
    Eric Wong; Fiscal Year: 2009
    ..The result of this work will be robust methods for measuring not only the amount of perfusion, but also the vascular source from which that perfusion was derived. ..
  41. CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NO
    Cristine L Heaps; Fiscal Year: 2010
    ....
  42. Anaplerotic therapy in Propionic Acidemia
    Nicola Longo; Fiscal Year: 2008
    ..This approach, if effective, could be extended to a number of other diseases, including other organic acidemias and mitochondrial disorders. [unreadable] [unreadable] [unreadable]..
  43. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  44. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  45. NON-INVASIVE EVALUATION OF ICP AND HEMODYNAMICS
    David Newell; Fiscal Year: 2002
    ..We then propose to test this method for accuracy of continuous recording of ICP under ICU conditions. ..
  46. Arterial Spin Labeling for fMRI
    Eric Wong; Fiscal Year: 2002
    ....
  47. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2002
    ..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
  48. Expression and function of PIGF in cardiomyocytes
    RONALD TORRY; Fiscal Year: 2003
    ..Collectively, these data may provide support for PIGF-mediated therapeutic approaches to facilitate coronary microvascular growth and/or reduce the cardiomyocyte loss associated with ischemic heart disease. ..
  49. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  50. Genetic Analysis of Vascular Aging
    Steven Miller; Fiscal Year: 2003
    ..abstract_text> ..
  51. ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The ultimate aim is the further understanding of the role of capillaries in the local regulation of MBF. ..
  52. Pyruvate-enhanced cardiopulmonary resuscitation
    Robert Mallet; Fiscal Year: 2004
    ....
  53. CHRONIC ISCHEMIC LEFT VENTRICULAR DYSFUNCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The drug we will test is carvedilol because of its unique adrenergic inhibitor properties as well as its anti-oxidant and anti-apoptotic properties. ..
  54. CORONARY MICROCIRCULATION-ACUTE MYOCARDIAL INFARCTION
    Sanjiv Kaul; Fiscal Year: 2004
    ..The study aims will be to test the 4 above-mentioned hypotheses in patients with suspected AMI. ..
  55. The Chemokine System in Collateral Artery Formation
    PAULA SHIREMAN; Fiscal Year: 2006
    ..These investigations, under the guidance of my mentors and coupled with the courses and seminars in this proposal will substantially broaden my scientific experience to allow me to become an independent scientist. ..
  56. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
  57. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2008
    ..abstract_text> ..
  58. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  59. NO production and S-nitrosylation in liver vasculature
    Yasuko Iwakiri; Fiscal Year: 2008
    ..The School of Medicine has pledged protected time for the candidate during this further training period prior to functioning as an independent investigator. ..
  60. MATRIXINS AND THEIR INHIBITORS IN ANGIOGENESIS
    QING XIANG SANG; Fiscal Year: 2002
    ..The role of each collagen-degrading matrixin in each step of angiogenesis in vitro will be assessed through intervention by the synthetic matrixin inhibitors. ..