collateral circulation

Summary

Summary: Maintenance of blood flow to an organ despite obstruction of a principal vessel. Blood flow is maintained through small vessels.

Top Publications

  1. doi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
  2. ncbi Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals
    J Waltenberger
    Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany
    Circulation 102:185-90. 2000
  3. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
  4. pmc Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications
    Joshua K Meisner
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Microcirculation 17:583-99. 2010
  5. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
  6. ncbi Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements
    Pascal Meier
    Department of Cardiology, University Hospital, CH 3010 Bern, Switzerland
    Circulation 116:975-83. 2007
  7. doi Stimulation of collateral artery growth: travelling further down the road to clinical application
    S H Schirmer
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Heart 95:191-7. 2009
  8. ncbi Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    Kerstin Wustmann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 107:2213-20. 2003
  9. ncbi Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2
    Matthias Heil
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 94:671-7. 2004
  10. ncbi A potential evidence to explain the reason behind the devastating prognosis of coronary artery disease in uraemic patients: renal insufficiency is associated with poor coronary collateral vessel development
    Murat Sezer
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, 34390, Capa Istanbul, Turkey
    Int J Cardiol 115:366-72. 2007

Research Grants

  1. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY ZAHARCHUK; Fiscal Year: 2009
  2. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY GEORGE ZAHARCHUK; Fiscal Year: 2010
  3. MYOCARDIAL BLOOD FLOW DURING ANESTHESIA
    Murali Sivarajan; Fiscal Year: 1980
  4. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
  5. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
  6. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1991
  7. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1992
  8. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1993
  9. FACTORS THAT REGULATE COLLATERAL PERFUSION
    David Harrison; Fiscal Year: 1991
  10. PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
    Brant Watson; Fiscal Year: 1993

Detail Information

Publications230 found, 100 shown here

  1. doi The impact of the coronary collateral circulation on mortality: a meta-analysis
    Pascal Meier
    The Heart Hospital, University College London Hospitals, Cardiology, London, UK
    Eur Heart J 33:614-21. 2012
    The coronary collateral circulation as an alternative source of blood supply has shown benefits regarding several clinical endpoints in patients with myocardial infarction (MI) such as infarct size and left ventricular remodelling...
  2. ncbi Vascular endothelial growth factor-A-induced chemotaxis of monocytes is attenuated in patients with diabetes mellitus: A potential predictor for the individual capacity to develop collaterals
    J Waltenberger
    Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany
    Circulation 102:185-90. 2000
    ..Thus far, it has not been possible to identify differences in individual responses to VEGF-A stimulation because of the lack of an ex vivo assay...
  3. ncbi Venous collateral circulation of the extracranial cerebrospinal outflow routes
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Curr Neurovasc Res 6:204-12. 2009
    ..We review the complex gross and radiological anatomy of collateral circulation found activated by the means of EchoColor-Doppler and selective venography in the event of CCSVI, focusing ..
  4. pmc Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications
    Joshua K Meisner
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Microcirculation 17:583-99. 2010
    ..We propose that an improved understanding of how arteriogenesis functions as a system can reveal individual BMC populations and functions that can be targeted for overcoming particular impairments in collateral vessel development...
  5. ncbi Natural killer cells and CD4+ T-cells modulate collateral artery development
    V van Weel
    Gaubius Laboratory, TNO QOL, P O Box 2215, 2301CE Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2310-8. 2007
    The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease...
  6. ncbi Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements
    Pascal Meier
    Department of Cardiology, University Hospital, CH 3010 Bern, Switzerland
    Circulation 116:975-83. 2007
    The prognostic relevance of the collateral circulation is still controversial...
  7. doi Stimulation of collateral artery growth: travelling further down the road to clinical application
    S H Schirmer
    Department of Cardiology, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Heart 95:191-7. 2009
    ..Future directions in the translation from bench to bedside and potential new approaches to the stimulation of vascular growth are discussed...
  8. ncbi Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    Kerstin Wustmann
    Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland
    Circulation 107:2213-20. 2003
    ..Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease...
  9. ncbi Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2
    Matthias Heil
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 94:671-7. 2004
    ..In conclusion, our results demonstrate that the CCR2 signaling pathway is essential for efficient collateral artery growth...
  10. ncbi A potential evidence to explain the reason behind the devastating prognosis of coronary artery disease in uraemic patients: renal insufficiency is associated with poor coronary collateral vessel development
    Murat Sezer
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, 34390, Capa Istanbul, Turkey
    Int J Cardiol 115:366-72. 2007
    The potential of individuals to develop coronary collateral circulation is often neglected but is of potential major importance in myocardial vulnerability...
  11. pmc Genetic architecture underlying variation in extent and remodeling of the collateral circulation
    Shiliang Wang
    Department of Cell and Molecular Physiology and the McAllister Heart Institute, University of North Carolina at Chapel Hill, NC 27599 7545, USA
    Circ Res 107:558-68. 2010
    ..Evidence suggests similar large differences exist among healthy humans...
  12. ncbi Collateralization and the response to obstruction of epicardial coronary arteries
    M H Tayebjee
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK
    QJM 97:259-72. 2004
    ..However, collateral circulation can protect and preserve myocardium around the time of coronary occlusion, contribute to better residual ..
  13. ncbi The human coronary collateral circulation
    Christian Seiler
    Cardiology, University Hospital, Bern, Switzerland
    Eur J Clin Invest 40:465-76. 2010
    ..Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) mitigate myocardial infarcts and improve survival...
  14. doi Determinants of preformed collateral vessels in the human heart without coronary artery disease
    Stefano F de Marchi
    Department of Cardiology, University Hospital, Bern, Switzerland
    Cardiology 118:198-206. 2011
    Coronary collaterals protect myocardium jeopardized by coronary artery disease (CAD). Promotion of collateral circulation is desirable before myocardial damage occurs...
  15. ncbi Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet Neurol 10:909-21. 2011
    ..Several interventions that might augment collateral blood flow are being investigated...
  16. ncbi Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention
    P Elsman
    Department of Cardiology, Isala Klinieken, locatie Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands
    Eur Heart J 25:854-8. 2004
    ....
  17. ncbi Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion
    W D Ito
    Department of Experimental Cardiology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Circ Res 80:829-37. 1997
    ..01; peripheral conductance, 119.3 +/- 22.37 versus 45.4 +/- 6.80 mL/min per 100 mm Hg; P < .05). These results suggest that activation of monocytes plays an important role in collateral growth as well as in capillary sprouting...
  18. ncbi Effect of coronary collaterals on microvascular obstruction as assessed by magnetic resonance imaging in patients with acute ST-elevation myocardial infarction treated by primary coronary intervention
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 104:1204-9. 2009
    ..5% vs 12.2%, p = 0.07). In conclusion, well-developed collaterals before reperfusion by PCI in patients with STEMI are associated with a protective effect on coronary microcirculation...
  19. pmc Formation and maturation of the native cerebral collateral circulation
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
    J Mol Cell Cardiol 49:251-9. 2010
    The native (pre-existing) collateral circulation minimizes tissue injury if obstructive vascular disease develops...
  20. pmc Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke
    Hua Zhang
    Department of Cell and Molecular Physiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    J Cereb Blood Flow Metab 30:923-34. 2010
    ..Whether differences in the extent of the native (preexisting) pial collateral circulation exist and contribute to this variability is unknown...
  21. pmc Endothelial nitric oxide synthase deficiency causes collateral vessel rarefaction and impairs activation of a cell cycle gene network during arteriogenesis
    Xuming Dai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 111 Mason Farm Rd, CB 7545, Chapel Hill, NC 27599, USA
    Circ Res 106:1870-81. 2010
    The collateral circulation is tissue- and life-saving in obstructive arterial disease. Disappointing outcomes in clinical trials aimed at augmenting collateral growth highlight the need for greater understanding of collateral biology.
  22. pmc Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues
    James E Faber
    Department of Physiology, McAllister Heart Institute, University of North Carolina, Chapel Hill, 27599 7545, USA
    Arterioscler Thromb Vasc Biol 31:1748-56. 2011
    ..Whether collateral rarefaction and impaired remodeling contribute to this is unknown. We quantified the number and diameter of native collaterals and their remodeling in 3-, 16-, 24-, and 31-month-old mice...
  23. doi Retrograde chronic total occlusion intervention: tips and tricks
    Eugene B Wu
    Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Catheter Cardiovasc Interv 72:806-14. 2008
    ..We hope that many others would find rewardingly successful cases of retrograde approach CTO percutaneous coronary intervention, as in our experience...
  24. ncbi Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia
    S Takeshita
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Circulation 98:1261-3. 1998
    ..The purpose of this study was to determine in vivo the extent to which vasomotor responses of collateral microvessels are altered after VEGF treatment...
  25. ncbi Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia model
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    Wound Repair Regen 15:58-65. 2007
    ..These results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/CH-LA/IO4-heparin induces angiogenesis and possibly collateral circulation in db/db mice and the ischemic limbs of rats.
  26. ncbi Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction
    Ji Song
    Dept of Biomedical Engineering, Univ of Virginia, Box 800759, UVA Health System, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 287:H2754-61. 2004
    ..We conclude that ultrasonic microbubble destruction can be tailored to stimulate an arteriogenesis response that restores hyperemia blood flow to skeletal muscle in a rat model of arterial occlusion...
  27. ncbi Congenital absence of the internal carotid artery: case reports and review of the collateral circulation
    C A Given
    Department of Neuroradiology, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157, USA
    AJNR Am J Neuroradiol 22:1953-9. 2001
    ..Recognition of this anomaly has important implications during planned carotid or transsphenoidal surgery, in thromboembolic disease, and in the surveillance and detection of associated cerebral aneurysms...
  28. ncbi Carotid artery occlusion and collateral circulation in C57Black/6J mice detected by synchrotron radiation microangiography
    Masahiro Tamaki
    Department of Neurosurgery, Kobe University Graduate School of Medicine
    Kobe J Med Sci 52:111-8. 2006
    ..We could successfully visualize the cerebral vasculature of normal mice and carotid artery occluded mice in an in vivo study. Microangiography can demonstrate the development of vasculature and the blood flow dynamics in mice...
  29. ncbi Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)
    D Scholz
    Department of Experimental Cardiology, Max Planck Institute, Bad Nauheim, Germany
    Virchows Arch 436:257-70. 2000
    ..We conclude that the process of arteriogenesis, which leads to the positive remodeling of an arteriole into an artery up to 12 times its original size, can be modified by modulators of inflammation...
  30. ncbi Effect of diabetes mellitus on formation of coronary collateral vessels
    A Abaci
    Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey
    Circulation 99:2239-42. 1999
    ..The nature of this variability is not well known. Likewise, it remains unclear whether diabetes mellitus (DM) has any effect on CCVs. The aim of this study was to evaluate the effect of DM on CCVs...
  31. ncbi The range of adaptation by collateral vessels after femoral artery occlusion
    Inka Eitenmüller
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Circ Res 99:656-62. 2006
    ..Increased FSS activates the Ras-ERK-, the Rho-, and the NO- (but not the Akt-) pathway enabling collateral artery growth...
  32. ncbi Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: quantification with MRI
    Lars Grosse-Wortmann
    The Labatt Family Heart Center and the Department of Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Circ Cardiovasc Imaging 2:219-25. 2009
    ..We aimed to quantify APC flow after bidirectional cavopulmonary connections and Fontan completions, using phase-contrast MRI, and to identify risk factors for the development of APCs...
  33. ncbi Coronary collateral flow in response to endurance exercise training
    Rainer Zbinden
    Department of Cardiology, University Hospital, Bern, Switzerland
    Eur J Cardiovasc Prev Rehabil 14:250-7. 2007
    ....
  34. ncbi Different strategies of retrograde approach in coronary angioplasty for chronic total occlusion
    Shigeru Saito
    Division of Cardiology and Catheterization Laboratories, Heart Center of ShonanKamakura General Hospital, Kamakura City, Japan
    Catheter Cardiovasc Interv 71:8-19. 2008
    ..Retrograde approach through the collateral channels has been recently proposed and has the potential to improve the success rate of percutaneous coronary intervention (PCI) in chronic total occlusion (CTO) lesions of the coronary arteries...
  35. doi Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    Marc Mejias
    Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clinic, CIBERehd, Barcelona, Spain
    Hepatology 49:1245-56. 2009
    ..Notably, beneficial effects of sorafenib against tissue damage and inflammation were also observed in splanchnic organs...
  36. doi Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation
    V van Weel
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Vasc Surg 22:582-97. 2008
    ..Better understanding of the highly complex molecular and cellular mechanisms of vascular growth may yet lead to meaningful clinical applications...
  37. doi Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial)
    E E Buschmann
    Franz Volhard Klinik, Department for Cardiology, Helios Klinikum Buch, Berlin, Germany
    Eur J Clin Invest 39:866-75. 2009
    ..The goal of this trial was to investigate the effect of external counterpulsation (ECP) on coronary collateral artery growth...
  38. ncbi Importance of collateral circulation in coronary heart disease
    Colin Berry
    Department of Medicine, Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
    Eur Heart J 28:278-91. 2007
    ..We endeavoured to review the methods for coronary artery collateral assessment, the predictors and clinical importance of collateral blood flow, and the potential for therapeutic augmentation of collateral anastomoses...
  39. doi Retrograde percutaneous recanalization of chronic total occlusion of the coronary arteries: procedural outcomes and predictors of success in contemporary practice
    Sudhir Rathore
    Department of Cardiology, Toyohashi Heart Center, 21 1 Gobudori, Oyama cho, Toyohashi, Japan
    Circ Cardiovasc Interv 2:124-32. 2009
    ..We investigated the safety and efficacy of retrograde approaches used for percutaneous recanalization of CTO in a consecutive series of patients...
  40. doi Coronary collaterals improve prognosis in patients with ischemic heart disease
    Jakub J Regieli
    Department of Cardiology, University Medical Center Utrecht, The Netherlands
    Int J Cardiol 132:257-62. 2009
    ..We examined the effects of coronary collateral circulation on cardiovascular outcomes, with an emphasis on clinical prognostic value and on a putative role of IHD ..
  41. pmc Noninvasive quantification of systemic-to-pulmonary collateral flow: a major source of inefficiency in patients with superior cavopulmonary connections
    Kevin K Whitehead
    Division of Cardiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Circ Cardiovasc Imaging 2:405-11. 2009
    ....
  42. ncbi Collateral pathways in superior vena caval obstruction as seen on CT
    M Cihangiroglu
    Department of Radiology, The University of Chicago, IL 60637, USA
    J Comput Assist Tomogr 25:1-8. 2001
    ..Many collateral patterns found in this series could not be classified with the existent classification scheme...
  43. doi Local cytokine concentrations and oxygen pressure are related to maturation of the collateral circulation in humans
    Stephan H Schirmer
    Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Am Coll Cardiol 53:2141-7. 2009
    Our aim was to determine cytokine and oxygen gradients over the collateral circulation in humans.
  44. doi Quantification of collateral aortopulmonary flow in patients subsequent to construction of bidirectional cavopulmonary shunts
    Ryo Inuzuka
    The Department of Pediatric Cardiology and Pediatric Cardiothoracic Surgery, Chiba Children s Hospital, Chiba, Japan
    Cardiol Young 18:485-93. 2008
    ..We sought to provide a new method for quantifying collateral aortopulmonary flow in patients subsequent to construction of a bidirectional cavopulmonary shunt, and to clarify the clinical advantages of the new method...
  45. pmc Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice
    Radia Tamarat
    Institut National de la Santé et de la Recherche Médicale U541, Hopital Lariboisiere, Institut fédératif de recherche Circulation Paris 7, Universite Paris 7 Denis Diderot, 75475 Paris Cedex 10, France
    Proc Natl Acad Sci U S A 100:8555-60. 2003
    ..This effect is probably mediated by restoration of matrix degradation processes that are disturbed as a result of AGE accumulation...
  46. doi Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model
    Konstantinos Katsanos
    Department of Radiology, Medical School, University of Patras, Patras, Greece
    J Vasc Surg 49:1000-12. 2009
    ..Based on these observations, we hypothesized that thrombin may promote the development of mature functional blood vessels...
  47. pmc The extent of the collateral circulation influences the postprandial increase in portal pressure in patients with cirrhosis
    Agustin Albillos
    Hospital Universitario Ramon y Cajal, Universidad de Alcala, Madrid, Spain
    Gut 56:259-64. 2007
    ..In cirrhosis, repeated flares of portal pressure and collateral blood flow provoked by postprandial hyperaemia may contribute to variceal dilation and rupture...
  48. doi Poor coronary collateral vessel development in patients with mild to moderate renal insufficiency
    Shuang Lun Xie
    Department of Cardiology, Sun Yat sen Memorial Hospital of Sun Yat sen University, West Yanjiang Road 107, Guangzhou, People s Republic of China
    Clin Res Cardiol 100:227-33. 2011
    ..The aim of this study was to investigate the relationship between mild to moderate renal insufficiency and coronary collateral development in patients with chronic total coronary artery occlusion...
  49. ncbi Screening for chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound--recommendations for a protocol
    P Zamboni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 30:571-97. 2011
    ..47 to k=0.80), while within-rater reproducibility in trained operators was k=0.75. Finally, the consensus document proposes a reporting standard of Duplex measurements, and future research to answer areas of uncertainty...
  50. ncbi Electrocardiographic changes of ST-elevation myocardial infarction in patients with complete occlusion of the left main trunk without collateral circulation: differential diagnosis and clinical considerations
    Miquel Fiol
    Hospital Son Espases, Palma de Mallorca, Spain
    J Electrocardiol 45:487-90. 2012
    ..We present a series of 7 patients with total left main trunk occlusion without collateral circulation showing ST-elevation myocardial infarction pattern...
  51. pmc Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease
    Po Chao Hsu
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC
    BMC Nephrol 13:98. 2012
    Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events...
  52. ncbi Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulation
    Dursun Aras
    Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Coron Artery Dis 17:159-63. 2006
    ..sought to determine the relationship between serum lipoprotein (a) levels and angiographically visible coronary collateral circulation and to evaluate whether lipoprotein (a) exerts any effect on vascular endothelial cell growth factor.
  53. ncbi Where there is blood, there is a way: unusual collateral vessels in superior and inferior vena cava obstruction
    Sangita Kapur
    Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45267 0761, USA
    Radiographics 30:67-78. 2010
    ..An understanding of these unusual collateral pathways is essential in a patient with caval occlusion who presents with signs and symptoms of a right-to-left shunt or has unusual enhancing lesions in the liver...
  54. doi Relation between fragmented QRS and collateral circulation in patients with chronic total occlusion without prior myocardial infarction
    Hasan Kadi
    Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
    Anadolu Kardiyol Derg 11:300-4. 2011
    ..We hypothesized that presence of fQRS on ECG may be related with poorly-grown collateral coronary circulation (CCC) in patients with chronic total coronary occlusion (CTO) without prior MI...
  55. ncbi The sword of Damocles: an illustrative example of the life-saving effect of the collateral circulation
    Pascal Meier
    University College London Hospital, 16 18 Westmoreland Street, London, United Kingdom
    J Invasive Cardiol 23:E47-8. 2011
    ..be it percutaneously or surgically; thus, people may question a significant benefit of the coronary collateral circulation. However, the presented 61-year-old male patient demonstrates an unambiguous situation of a life-saving ..
  56. doi Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery disease
    Song ming Chen
    Department of Cardiology, First Affiliated Hospital, Shantou, Guangdong, China
    Coron Artery Dis 19:173-9. 2008
    ..It could play an important role in modulating collateral development...
  57. doi Indocyanine green (ICG) temporary clipping test to assess collateral circulation before venous sacrifice
    Paolo Ferroli
    Neurosurgery, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy
    World Neurosurg 75:122-5. 2011
    ..At present, no method exists to predict whether such sacrifice will be accommodated by the presence of collateral venous drainage. We show a simple technique to examine cerebral venous blood flow using indocyanine green videoangiography...
  58. ncbi Impaired coronary collateral vessel development in patients with metabolic syndrome
    Hasan Turhan
    Department of Cardiology, Inonu University, Malatya and Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
    Coron Artery Dis 16:281-5. 2005
    ..and evidence of myocardial ischemia suggest that some other factors may affect the development of collateral circulation. In the present study we aimed to evaluate coronary collateral circulation in patients with metabolic ..
  59. doi Extrahepatic collateral artery supply to the tumor thrombi of hepatocellular carcinoma invading inferior vena cava: the prevalence and determinant factors
    In Joon Lee
    Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
    J Vasc Interv Radiol 20:22-9. 2009
    ..To retrospectively evaluate the prevalence of extrahepatic collateral artery supply to tumor thrombi of hepatocellular carcinomas (HCCs) invading the inferior vena cava (IVC) and to assess the determining factors...
  60. ncbi Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis
    Makoto Sumi
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Arterioscler Thromb Vasc Biol 27:813-8. 2007
    ..Here, we investigated the effect of HDL on differentiation of endothelial progenitor cells and angiogenesis in murine ischemic hindlimb model...
  61. ncbi Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease
    Tsung Hsien Lin
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
    Clin Chim Acta 411:1688-93. 2010
    ..This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD)...
  62. ncbi Preliminary results of Tc-99m ECD SPECT to evaluate cerebral collateral circulation during balloon test occlusion
    Yuka Yamamoto
    Department of Radiology, Faculty of Medicine, Kagawa Medical University, Japan
    Clin Nucl Med 27:633-7. 2002
    ..of regional cerebral blood flow using Tc-99m L,L-ethyl cysteinate dimer (Tc-99m ECD) SPECT to evaluate cerebral collateral circulation during balloon test occlusion (BTO) of the internal carotid artery and vertebral artery (VA).
  63. pmc Strain-dependent variation in collateral circulatory function in mouse hindlimb
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina 27599 7545, USA
    Physiol Genomics 42:469-79. 2010
    The extent (density and diameter) of the native (preexisting) collateral circulation in healthy tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are important determinants of ischemic injury...
  64. ncbi Characterization and treatment of systemic venous to pulmonary venous collaterals seen after the Fontan operation
    Hisashi Sugiyama
    Department of Pediatrics and Diagnostic Imaging, The Hospital for Sick Children, The University of Toronto, School of Medicine, Toronto, Ontario, Canada
    Cardiol Young 13:424-30. 2003
    ..To determine the anatomical characteristics of systemic venous collaterals formed after the Fontan operation, and the efficacy of a transcatheter strategy for management...
  65. ncbi The power of collateral circulation: a case of asymptomatic chronic total occlusion of the left main coronary artery
    Tajinderpal Saraon
    Division of Cardiology, Department of Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY 11212 USA
    J Invasive Cardiol 24:E196-8. 2012
    ..This case demonstrates the power of collateral circulation in protecting the patient from symptoms and death despite total occlusion of the left main coronary artery ..
  66. ncbi Absence of myocardial ischemia during sudden controlled occlusion of coronary arteries in patients with well-developed collateral vessels
    K Miwa
    Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Coron Artery Dis 10:459-63. 1999
    ....
  67. ncbi [Collateral circulation of the left colon: historic considerations and actual clinical significance]
    K Renner
    Chirurgische Abteilung, Donauspital am SMZ Ost, Vienna, Austria
    Chirurg 74:575-8. 2003
    ..The arterial communication between the superior and inferior mesenteric arteries is important in surgery of the colon and aorta...
  68. ncbi Humoral and cellular factors responsible for coronary collateral formation
    Jonathan A Sherman
    Section of Cardiology, Department of Medicine, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Cardiol 98:1194-7. 2006
    ..Rather, cellular properties, such as cell adhesion, or genetic differences between patients may be the driving force for collateral development...
  69. ncbi Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function
    Gerald S Werner
    Clinic for Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany
    Circulation 110:1940-5. 2004
    ..Despite extensive animal experimental evidence, there are few data on the relation of growth factors and collateral function in humans...
  70. ncbi Role of coronary collaterals in off-pump and on-pump coronary bypass surgery
    Hendrik M Nathoe
    Department of Cardiology, Heart Lung Center Utrecht, Utrecht, The Netherlands
    Circulation 110:1738-42. 2004
    ..The role of collaterals has not been studied in patients undergoing off-pump or on-pump bypass surgery...
  71. ncbi Association between the dosage and duration of statin treatment with coronary collateral development
    Irem Dincer
    Ankara University Faculty of Medicine, Dikmen, Ankara, Turkey
    Coron Artery Dis 17:561-5. 2006
    The coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease and the therapeutic promotion of collateral growth appears to be a valuable treatment strategy ..
  72. ncbi Coronary collateral circulation: effect on early and midterm outcomes after off-pump coronary artery bypass surgery
    Massimo Caputo
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 85:71-9. 2008
    ..The purpose of this study was to assess the prognostic effect of coronary collaterals on early and midterm clinical outcomes in patients undergoing first time isolated off-pump coronary artery bypass (OPCAB) surgery...
  73. ncbi Leg ischemia: assessment with MR angiography and spectroscopy
    Iris Baumgartner
    Swiss Cardiovascular Center, Division of Angiology and Departments of Diagnostic, Interventional, and Pediatric Radiology, University Hospital Bern, Freiburgstrasse 10, 3010 Bern, Switzerland
    Radiology 234:833-41. 2005
    ....
  74. ncbi Comparison of the cardioprotective effect of prodromal angina pectoris and collateral circulation in patients with a first anterior wall acute myocardial infarction
    Masaharu Ishihara
    Department of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
    Am J Cardiol 95:622-5. 2005
    To compare the cardioprotective effect of prodromal angina pectoris and collateral circulation, 245 patients with first anterior acute myocardial infarction who underwent coronary angioplasty within 12 hours of symptoms were studied...
  75. pmc Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy
    R Zbinden
    Department of Cardiology, University Hospital Bern, Bern, Switzerland
    Heart 91:1289-93. 2005
    ..To determine the influence of diabetes mellitus on coronary collateral flow by accurate means of collateral flow measurement in a large population with variable degrees of coronary artery disease...
  76. ncbi Prognostic significance of coronary collaterals in patients with coronary heart disease having percutaneous transluminal coronary angioplasty
    Jeroen Koerselman
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Am J Cardiol 96:390-4. 2005
    ..In patients with ischemic heart disease, the angiographic presence of coronary collaterals may mark an unfavorable prognosis, particularly in relatively high-risk patients...
  77. ncbi Determinants and prognostic significance of collaterals in patients undergoing coronary revascularization
    Hendrik M Nathoe
    Department of Cardiology, Heart Lung Center Utrecht, Utrecht
    Am J Cardiol 98:31-5. 2006
    ..Variables that reflect the duration and severity of the atherosclerotic and ischemic burden determine their presence...
  78. ncbi Impact of coronary collaterals on outcome following percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)
    J Dawn Abbott
    Division of Cardiology, Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
    Am J Cardiol 96:676-80. 2005
    Coronary collateral circulation is beneficial in patients with coronary artery disease, but controversy still exists regarding the association between angiographic collaterals and outcome after percutaneous coronary intervention (PCI)...
  79. ncbi Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals
    Carlo Briguori
    Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy
    Am J Cardiol 97:472-6. 2006
    ..In conclusion, plasma levels of angiogenic growth factors differ among patients with stable angina pectoris and longstanding total coronary occlusion...
  80. ncbi Differential effects of MCP-1 and leptin on collateral flow and arteriogenesis
    Stephan H Schirmer
    Research Group for Experimental and Clinical Arteriogenesis, Department of Internal Medicine III Cardiology and Angiology, University Hospital Freiburg, Breisacher Strasse 66 ZKF, D 79106 Freiburg, Germany
    Cardiovasc Res 64:356-64. 2004
    ....
  81. ncbi Effect of glucometabolic disorders on the formation of coronary collaterals in occlusive coronary artery disease
    Zekeriya Nurkalem
    Siyami Ersek Thoracic and Cardiovascular Surgery Center, Cardiology Department, Istanbul, Turkey
    Acta Cardiol 63:141-6. 2008
    ..The primary aim of this study was to assess the effect of glucometabolic disorders on coronary collateral vessels in patients with occlusive coronary artery disease...
  82. ncbi Extrahepatic collateral supply of hepatocellular carcinoma by the intercostal arteries
    Sung Il Park
    Department of Diagnostic Radiology, Soonchunhyang University Chonan Hospital, Chonan, South Korea
    J Vasc Interv Radiol 14:461-8. 2003
    ....
  83. ncbi Collateral circulation via the ophthalmic artery or leptomeningeal vessels is associated with impaired cerebral vasoreactivity in patients with symptomatic carotid artery occlusion
    J Hofmeijer
    University Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 14:22-6. 2002
    ..leptomeningeal vessels have been considered secondary collaterals, which are recruited only if the primary collateral circulation via the circle of Willis is insufficient...
  84. ncbi Relationship between pressure-derived collateral blood flow and diabetes mellitus in patients with stable angina pectoris: a study based on coronary pressure measurement
    Yilmaz Nisanci
    Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology, Istanbul, Turkey
    J Invasive Cardiol 14:118-22. 2002
    ..Coronary angiography, the most commonly used technique for studying collateral circulation, may not be accurate in assessing collateral circulation because most collaterals are situated ..
  85. ncbi Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor
    Keisuke Kondoh
    Department of Vascular Regeneration, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cardiovasc Res 61:132-42. 2004
    ....
  86. doi Territorial arterial spin labeling in the assessment of collateral circulation: comparison with digital subtraction angiography
    Soke Miang Chng
    Department of Neuroradiology, National Neuroscience Institute, Singapore
    Stroke 39:3248-54. 2008
    b>Collateral circulation plays a vital role in patients with steno-occlusive disease, in particular for predicting stroke outcome...
  87. ncbi Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease
    Vipul R Panchal
    Department of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Am Coll Cardiol 43:1383-7. 2004
    ..levels of a pro-angiogenic factor (vascular endothelial growth factor, VEGF) or an anti-angiogenic factor (endostatin) related to the presence of coronary collateral circulation in patients with significant coronary artery disease (CAD).
  88. doi Effect of coronary collaterals on long-term prognosis in patients undergoing primary angioplasty for acute ST-elevation myocardial infarction
    Steffen Desch
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Germany
    Am J Cardiol 106:605-11. 2010
    ..In conclusion, the presence of a well-developed collateral network before mechanical reperfusion in patients with STEMI is associated with improved long-term survival and lower major adverse cardiovascular event rates...
  89. ncbi Cross-sectional pattern of collateral vessels in patients with superficial femoral artery occlusion
    M B Wecksell
    Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA
    Invest Radiol 36:422-9. 2001
    ..CONCLUSIONS: The majority of collateral vessels in the thigh are located in the fat or muscle within the posterior compartment near the femur at the level of the adductor canal...
  90. ncbi [A case of repeated intracerebral hemorrhage due to a ruptured aneurysm of collateral circulation from the posterior cerebral artery to the middle cerebral artery]
    Ayumi Narisawa
    Department of Neurosurgery, Saitama Red Cross Hospital, Japan
    No Shinkei Geka 37:787-92. 2009
    ..Even if intraparenchymal hematoma presents without SAH, and even if it is located at a rare site for aneurysms, we should inspect the source of bleeding considering factors preventing SAH arising from aneurysms...
  91. ncbi Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution
    D F Lazarous
    Experimental Physiology and Pharmacology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cardiovasc Res 36:78-85. 1997
    ..This study evaluated differential regional uptake of 125I labeled bFGF following bolus intravenous, Swan Ganz, left atrial, intracoronary, and pericardial delivery...
  92. doi Magnetic resonance angiography of collateral blood supply to spinal cord in thoracic and thoracoabdominal aortic aneurysm patients
    Walter H Backes
    Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands
    J Vasc Surg 48:261-71. 2008
    ....
  93. ncbi Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
    Nat Med 9:604-13. 2003
    ..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases...
  94. ncbi Physiologically assessed coronary collateral flow and adverse cardiac ischemic events: a follow-up study in 403 patients with coronary artery disease
    Michael Billinger
    Division of Cardiology, Swiss Cardiovascular Center Bern, CH 3010 Bern, Switzerland
    J Am Coll Cardiol 40:1545-50. 2002
    ..We sought to evaluate whether coronary collateral flow is clinically relevant for future cardiac ischemic events...
  95. ncbi [Development of pre-hepatic portal hypertension of the rat]
    M A Aller Reyero
    Facultad de Medicina, Universidad Complutense, Pza Ramón y Cajal s n, 28040 Madrid
    An Med Interna 19:341-51. 2002
    ..A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat...
  96. ncbi Risk factors for poor collateral development in claudication
    Salvatore De Vivo
    Department of Vascular Surgery, Karolinska Hospital, Stockholm, Sweden
    Vasc Endovascular Surg 39:519-24. 2005
    ..In patients with claudication and SFA occlusion, few collaterals from the deep femoral artery appear to be associated with having diabetes and a short duration of symptoms...
  97. ncbi The relationship of chronic angiotensin converting enzyme inhibitor use and coronary collateral vessel development
    Timucin Altin
    Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey
    Int Heart J 48:435-42. 2007
    ..We hypothesized that the blockage of angiotensin II production by ACE inhibitors might interfere with collateral development in patients with coronary occlusion...
  98. ncbi Coronary collateralization: determinants of adequate distal vessel filling after arterial occlusion
    Jens G Kilian
    Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Coron Artery Dis 13:155-9. 2002
    ..The protective effect of collateral vessels in coronary artery disease (CAD) is well established. Little is known, however, about factors that influence collateral formation...
  99. ncbi MR regional perfusion imaging: visualizing functional collateral circulation
    C C T Lim
    Department of Neuroradiology, National Neuroscience Institute, Singapore
    AJNR Am J Neuroradiol 28:447-8. 2007
    ..RPI may be useful to study functional collateral circulation and hence guide therapy in ischemic disease.
  100. ncbi Elevated levels of C-reactive protein are associated with impaired coronary collateral development
    S Gulec
    Department of Cardiology, School of Medicine, Ankara University, Ankara, Turkey
    Eur J Clin Invest 36:369-75. 2006
    ..The aim of this study was to investigate the association between high sensitivity CRP (hsCRP) levels and the extent of coronary collaterals...
  101. ncbi Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation
    Niels van Royen
    Max Planck Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Bad Nauheim, Germany
    FASEB J 16:432-4. 2002
    ..led to an increase in both the number of visible collateral arteries as well as the conductance of the collateral circulation (4.0 +/- 0.5 ml/min/100 mmHg vs. 28.9 +/- 3.7 ml/min/100 mmHg, P<0.05)...

Research Grants70

  1. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY ZAHARCHUK; Fiscal Year: 2009
    ..population for this study, as they tend to be young and otherwise healthy, but typically have extensive collateral circulation. We also aim to demonstrate that ASL CBF measurements sensitive to slow flow, such as long post-label ..
  2. Quantifying Collateral Perfusion in Cerebrovascular Disease
    GREGORY GEORGE ZAHARCHUK; Fiscal Year: 2010
    ..population for this study, as they tend to be young and otherwise healthy, but typically have extensive collateral circulation. We also aim to demonstrate that ASL CBF measurements sensitive to slow flow, such as long post-label ..
  3. MYOCARDIAL BLOOD FLOW DURING ANESTHESIA
    Murali Sivarajan; Fiscal Year: 1980
    ..and phentolamine produce a steal phenomenon (decreased collateral blood flow) in the heart in which collateral circulation has developed secondary to a coronary occlusion...
  4. Reactive Oxygen Species in Coronary Collateral Growth
    WILLIAM CHILIAN; Fiscal Year: 2009
    ..the cell type or types in the heart responsible for redox signaling in the growth of the coronary collateral circulation in response to repetitive ischemia...
  5. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2010
    ..the cell type or types in the heart responsible for redox signaling in the growth of the coronary collateral circulation in response to repetitive ischemia...
  6. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1991
    ..collateral blood flow, a second major objective will be to determine the effects of KCOs on the coronary collateral circulation in dogs with different degrees of collateral development...
  7. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1992
    ..collateral blood flow, a second major objective will be to determine the effects of KCOs on the coronary collateral circulation in dogs with different degrees of collateral development...
  8. EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
    Garrett Gross; Fiscal Year: 1993
    ..collateral blood flow, a second major objective will be to determine the effects of KCOs on the coronary collateral circulation in dogs with different degrees of collateral development...
  9. FACTORS THAT REGULATE COLLATERAL PERFUSION
    David Harrison; Fiscal Year: 1991
    ..During the next 5 years, we plan to extend our studies of the collateral circulation. Specifically, we plan studies to determine what factors modulate the opening of partially developed and ..
  10. PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
    Brant Watson; Fiscal Year: 1993
    ..Observation of infarct mitigation by EDRF stimulation would suggest that EDRF-induced activation of collateral circulation be used clinically to reduce infarct volume, even if the MCA (or other intracranial artery) remains ..
  11. PEROXYLIPIDS/NITRIC OXIDE IN THROMBOTIC STROKE
    Brant Watson; Fiscal Year: 1992
    ..Observation of infarct mitigation by EDRF stimulation would suggest that EDRF-induced activation of collateral circulation be used clinically to reduce infarct volume, even if the MCA (or other intracranial artery) remains ..
  12. Effects of Diabetes Mellitus on the Development of Collateral Criculation
    Divya Gupta; Fiscal Year: 2009
    ..This interaction and its involvement in collateral circulation is relevant to the health of the millions of diabetic patients in the world...
  13. EFFECT OF HYPERTENSION AND HYPERTROPHY ON LV ISCHEMIA
    PETER ROAN; Fiscal Year: 1980
    ..compared between groups of animals since the variability in infarct size arising from differences in collateral circulation is reduced. Infarct size can then be expressed as percent LAD bed at risk...
  14. MYOCARDIAL HYPERTROPHY & FAILURE IN CONSCIOUS ANIMALS
    STEPHEN VATNER; Fiscal Year: 1980
    ..Alterations in the regional distribution of myocardial blood flow, as well as the development of coronary collateral circulation in hypertrophied and failing hearts will be measured by the radioactive microsphere technique...
  15. Stem cell-based therapy in heart failure: aging effects
    Mohamed Gaballa; Fiscal Year: 2003
    Induction of collateral circulation after myocardial infarction (MI) is impaired in aging. However, the mechanisms of this impairment are unclear...
  16. HYPOTENSION, RENAL ISCHEMIA AND EFFECT OF MANNITOL
    Norman Levinsky; Fiscal Year: 1980
    ..Evaluate the functional significance of collateral circulation in the dog kidney during complete and partial renal artery occlusion...
  17. ANTI INFARCTION EFFECTS IN THE DENERVATED HEART
    PATRICIA GWIRTZ; Fiscal Year: 1993
    ..chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as does surgical sympathectomy...
  18. ANTI INFARCTION EFFECTS IN THE DENERVATED HEART
    Carl Jones; Fiscal Year: 1991
    ..chemical sympathectomy [by topical application of phenol] exerts the same influence on the coronary collateral circulation as does surgical sympathectomy...
  19. CINEANGIOGRAPHIC STUDIES OF THE CARDIOVASCULAR SYSTEM
    Herbert Abrams; Fiscal Year: 1980
    ..Additional studies will concentrate on determinants of collateral vessel formation; the intercoronary collateral circulation; vasa vasorum blood flow in the aortic wall during atheromatosis and after trauma; and the determinants of ..
  20. Replication deficient adenovirus containing VEGF cDNA to ischemic lower limb of
    Sanjay Rajagopalan; Fiscal Year: 2000
    ..is therapeutic antiogenesis or the creation of new networks of blood vessels that provide a system of collateral circulation, that then provide a bypass mechanism...
  21. COMPARATIVE PATHOPHYSIOLOGY OF MYOCARDIAL ISCHEMIA
    Robert Elsner; Fiscal Year: 1980
    ..hypoxia of diving, including: myocardial metabolism, determinants of oxygen consumption, development of collateral circulation in response to ischemia and mitochondrial function hypoxic and ischemic myocardium...
  22. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2004
    ..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
  23. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2005
    ..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
  24. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
  25. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2003
    ..Potential mechanisms to explain the protective effect of exercise include improved collateral circulation, elevation of cardiac heat shock proteins, and increased myocardial antioxidant capacity...
  26. FUNCTION AND GROWTH OF CORONARY COLLATERAL VESSELS
    John Longhurst; Fiscal Year: 1990
    ..The purpose of the proposed research is to further develop a model of the coronary collateral circulation and to examine various mechanisms that may enhance or retard development of this circulation and capillary ..
  27. MECHANISM OF CORONARY VASCULAR ADAPTATION
    KONRAD SCHEEL; Fiscal Year: 1992
    The collateral circulation is the only source of blood supply to the myocardium after an acute coronary occlusion. During recovery, it constitutes nature's own repair process by developing new vascular growth...
  28. CORONARY OCCLUSION--COLLATERAL ARTERY FUNCTION
    Janet Parker; Fiscal Year: 1992
    ..An important natural defense mechanism of the diseased heart is the collateral circulation, which increases in structure and function under the influence of myocardial ischemia and hypoxia...
  29. CORONARY COLLATERAL CIRCULATION IN MYOCARDIAL ISCHEMIA
    EDWARD KIRK; Fiscal Year: 1980
    Following acute coronary occulsion, the coronary collateral circulation becomes the primary determinant of the extent of ischemia within the involved myocardium...
  30. Therapeutic angiogenesis to treat ischemic disorders
    Keith Webster; Fiscal Year: 2001
    ..or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate collateral circulation, and improve tissue function...
  31. Therapeutic angiogenesis to treat ischemic disorders
    Keith Webster; Fiscal Year: 2002
    ..or intracoronary infusions of naked and adenoviral DNA, have been shown to induce angiogenesis, stimulate collateral circulation, and improve tissue function...
  32. Collateral Circulation in Acute Ischemic Stroke
    David Liebeskind; Fiscal Year: 2006
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  33. Collateral Circulation in Acute Ischemic Stroke
    DAVID SIGMUND LIEBESKIND; Fiscal Year: 2010
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  34. Collateral Circulation in Acute Ischemic Stroke
    David Liebeskind; Fiscal Year: 2009
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  35. Collateral Circulation in Acute Ischemic Stroke
    David Liebeskind; Fiscal Year: 2007
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  36. CIRCULATORY AND METABOLIC ADAPTATIONS IN ISCHEMIC LIMBS
    Martin Kushmerick; Fiscal Year: 1990
    ..We will document by angiography the time course and extent of collateral circulation development, and assess its functional capacity by direct blood flow measurements...
  37. Collateral Circulation in Acute Ischemic Stroke
    David Liebeskind; Fiscal Year: 2009
    b>Collateral circulation is a fundamental component of stroke pathophysiology that has been relatively unexplored...
  38. Angiogenesis in Diseased Model
    Nilanjana Maulik; Fiscal Year: 2009
    ..Abnormalities of the coronary collateral circulation have been reported in clinical and experimental diabetes mellitus...
  39. INTRACORONARY DELIVERY OF PLASMID DNA TO CARDIAC TISSUES
    Hans Herweijer; Fiscal Year: 2001
    ..development is an important adaptive response of the ischemic heart in this situation, but often the collateral circulation is inadequate and results in severe angina pectoris despite maximal medical therapy...
  40. NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGE
    Marsha Moses; Fiscal Year: 2000
    ..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
  41. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2000
    Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
  42. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2001
    Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
  43. NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGE
    Marsha Moses; Fiscal Year: 1999
    ..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
  44. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2003
    Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
  45. Angiogenesis in Diseased Model
    Nilanjana Maulik; Fiscal Year: 2010
    ..Abnormalities of the coronary collateral circulation have been reported in clinical and experimental diabetes mellitus...
  46. NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGE
    Marsha Moses; Fiscal Year: 2001
    ..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
  47. INTRACORONARY DELIVERY OF PLASMID DNA TO CARDIAC TISSUES
    Hans Herweijer; Fiscal Year: 1999
    ..development is an important adaptive response of the ischemic heart in this situation, but often the collateral circulation is inadequate and results in severe angina pectoris despite maximal medical therapy...
  48. HYPOXIA INDUCIBLE VEGF PRODUCTION IN SLEEP APNEA
    Andrew Levy; Fiscal Year: 2002
    Angiogenesis is the physiological adaptive response of a tissue to hypoxia. The coronary collateral circulation of the heart represents such an adaptive response and is an important determinant in the extent of tissue damage following ..
  49. NOVEL ANGIOGENESIS INHIBITOR FROM CARTILAGE
    Marsha Moses; Fiscal Year: 2002
    ..these latter cases, the ability to induce neovascularization, revascularize damaged tissue and develop the collateral circulation would be desirable...
  50. INTRACORONARY DELIVERY OF PLASMID DNA TO CARDIAC TISSUES
    Hans Herweijer; Fiscal Year: 2000
    ..development is an important adaptive response of the ischemic heart in this situation, but often the collateral circulation is inadequate and results in severe angina pectoris despite maximal medical therapy...
  51. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2007
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  52. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2006
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  53. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2005
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  54. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2005
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  55. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2004
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  56. MECHANISMS OF CARDIOVASCULAR REACTION TO INJURY
    CHARLES MURRY; Fiscal Year: 2003
    ..RGS proteins are critical mediators of vascular hypertrophy in hypertensive remodeling and formation of collateral circulation. These 3 projects are supported by an Animal/Tissue Core to assist in mouse husbandry and histology and by ..
  57. MRI OF CORONARY COLLATERALS
    Justin Pearlman; Fiscal Year: 1999
    ..Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia...
  58. DETERMINANTS OF CORONARY COLLATERAL DEVELOPMENT
    COLIN BLOOR; Fiscal Year: 1999
    DESCRIPTION: Survival of the ischemic heart is dependent on the growth of the collateral circulation. However, collateral development is frequently not sufficient to fully meet the blood supply needs of the compromised myocardium...
  59. MRI OF CORONARY COLLATERALS
    Justin Pearlman; Fiscal Year: 2000
    ..Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia...
  60. Genetic basis of coronary artery disease /collateralization
    CLARENCE GRIM; Fiscal Year: 2000
    ..Collectively, we believe our study will provide one of the most complete analyses in revealing insight into the genetic basis of coronary artery disease and growth of the coronary collateral circulation.
  61. MRI OF COLLATERAL DEVELOPMENT IN THE HEART
    Michael Jerosch Herold; Fiscal Year: 2000
    DESCRIPTION (Adapted from Applicants Abstract): In ischemic heart disease the presence and extent of collateral circulation can prevent myocardial infarction, or at least limit the damage and reduce the size of infarcts...
  62. MRI OF COLLATERAL DEVELOPMENT IN THE HEART
    Michael Jerosch Herold; Fiscal Year: 2001
    DESCRIPTION (Adapted from Applicants Abstract): In ischemic heart disease the presence and extent of collateral circulation can prevent myocardial infarction, or at least limit the damage and reduce the size of infarcts...
  63. MRI OF CORONARY COLLATERALS
    Justin Pearlman; Fiscal Year: 2000
    ..Recent studies have shown that certain growth factors increase the collateral circulation in chronic ischemia...