platelet adhesiveness

Summary

Summary: The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.

Top Publications

  1. ncbi Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor
    Daisuke Mori
    Department of Bioengineering and Robotics, Tohoku University, 6 6 01 Aoba, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Thromb Haemost 99:108-15. 2008
  2. ncbi Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III
    Nicolas Raynal
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:3821-31. 2006
  3. ncbi Activation-independent platelet adhesion and aggregation under elevated shear stress
    Zaverio M Ruggeri
    The Scripps Research Institute MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 108:1903-10. 2006
  4. ncbi Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
    H Ni
    The Center for Blood Research, Boston, Massachusetts 02115, USA
    J Clin Invest 106:385-92. 2000
  5. ncbi Glycocalyx-mimetic dextran-modified poly(vinyl amine) surfactant coating reduces platelet adhesion on medical-grade polycarbonate surface
    A Sen Gupta
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biomaterials 27:3084-95. 2006
  6. ncbi The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques
    Anna Babinska
    Department of Anatomy Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Thromb Haemost 97:272-81. 2007
  7. ncbi A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion
    Yung Chang
    R and D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong Li, Taoyuan 320, Taiwan
    Langmuir 24:5453-8. 2008
  8. ncbi Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow
    Mario Mazzucato
    Department of Laboratory Medicine, Centro di Riferimento Oncologico CRO National Cancer Institute, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Aviano PN, Italy
    Blood 114:2793-801. 2009
  9. ncbi Blood coagulation on biomaterials requires the combination of distinct activation processes
    Claudia Sperling
    Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany
    Biomaterials 30:4447-56. 2009
  10. ncbi Hemocompatibility of materials used in microelectromechanical systems: platelet adhesion and morphology in vitro
    Brian A Weisenberg
    University of Minnesota, The Biomedical Engineering Institute, Minneapolis, Minnesota 55455, USA
    J Biomed Mater Res 60:283-91. 2002

Research Grants

  1. Initiation and Regulation of Platelet Thrombus Formation
    ZAVERIO RUGGERI; Fiscal Year: 2004
  2. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
  3. Mechanisms of Thrombus Instability
    ZAVERIO RUGGERI; Fiscal Year: 2007
  4. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
  5. Role of von Willebrand Factor in Platelet Thrombus Formation
    Zaverio M Ruggeri; Fiscal Year: 2010
  6. Platelet interactions with vessel wall components
    ZAVERIO RUGGERI; Fiscal Year: 2005
  7. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
  8. Thrombus Formation and Antithrombotic Intervention
    ZAVERIO RUGGERI; Fiscal Year: 2007
  9. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2007
  10. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002

Detail Information

Publications184 found, 100 shown here

  1. ncbi Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor
    Daisuke Mori
    Department of Bioengineering and Robotics, Tohoku University, 6 6 01 Aoba, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Thromb Haemost 99:108-15. 2008
    ....
  2. ncbi Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III
    Nicolas Raynal
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:3821-31. 2006
    ..We describe two novel high affinity integrin-binding motifs in human collagen III (GROGER and GLOGEN) and a third motif (GLKGEN) that displays intermediate activity. Each motif was verified using shorter synthetic peptides...
  3. ncbi Activation-independent platelet adhesion and aggregation under elevated shear stress
    Zaverio M Ruggeri
    The Scripps Research Institute MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 108:1903-10. 2006
    ..Platelet and VWF modulation by hydrodynamic force is a mechanism for activation-independent aggregation that may support thrombotic arterial occlusion...
  4. ncbi Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
    H Ni
    The Center for Blood Research, Boston, Massachusetts 02115, USA
    J Clin Invest 106:385-92. 2000
    ..Platelets of these doubly deficient mice specifically accumulated fibronectin in their alpha-granules, suggesting that fibronectin could be the ligand supporting the platelet aggregation...
  5. ncbi Glycocalyx-mimetic dextran-modified poly(vinyl amine) surfactant coating reduces platelet adhesion on medical-grade polycarbonate surface
    A Sen Gupta
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biomaterials 27:3084-95. 2006
    ..The results suggest potential application of carbohydrate-modified surfactant polymers as a glycocalyx-mimetic non-thrombogenic interfacial coating for blood-contacting biomaterials...
  6. ncbi The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques
    Anna Babinska
    Department of Anatomy Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Thromb Haemost 97:272-81. 2007
    ....
  7. ncbi A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion
    Yung Chang
    R and D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong Li, Taoyuan 320, Taiwan
    Langmuir 24:5453-8. 2008
    ..This work further concludes that a surface with good hemocompatibility can be achieved by the well-packed surface-grafted polySBMA brushes...
  8. ncbi Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow
    Mario Mazzucato
    Department of Laboratory Medicine, Centro di Riferimento Oncologico CRO National Cancer Institute, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Aviano PN, Italy
    Blood 114:2793-801. 2009
    ..Our results delineate a GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation...
  9. ncbi Blood coagulation on biomaterials requires the combination of distinct activation processes
    Claudia Sperling
    Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany
    Biomaterials 30:4447-56. 2009
    ..Successful surface design strategies for hemocompatible materials therefore need to carefully consider the interplay of both processes...
  10. ncbi Hemocompatibility of materials used in microelectromechanical systems: platelet adhesion and morphology in vitro
    Brian A Weisenberg
    University of Minnesota, The Biomedical Engineering Institute, Minneapolis, Minnesota 55455, USA
    J Biomed Mater Res 60:283-91. 2002
    ..These results may be helpful in guiding the selection of materials for use in the development of blood-contacting microelectromechanical systems...
  11. ncbi A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, Germany
    J Exp Med 196:887-96. 2002
    ..These findings establish the platelet as a major player in initiation of the atherogenetic process...
  12. ncbi Modification of Si(100) surface by the grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion
    F Zhang
    Department of Chemical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Biomed Mater Res 56:324-32. 2001
    ..The grafted PEGMA polymer layer on the Si(100) surface exhibited fairly good stability during storage in a buffer solution...
  13. ncbi Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 92:507-15. 1998
    ..Platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury...
  14. ncbi Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
    T C White
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Thromb Haemost 6:995-1002. 2008
    ..Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if protein C interacts with cells in an alternative manner...
  15. ncbi Time sequence of blood activation by nanoporous alumina: Studies on platelets and complement system
    Natalia Ferraz
    Department of Physical and Analytical Chemistry, BMC, Uppsala University, Sweden
    Microsc Res Tech 73:1101-9. 2010
    ..The surface topography of the alumina most probably influence protein transition rate, which in turn affects material platelet activation kinetics...
  16. ncbi Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa
    Malgorzata B Sobocka
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Recept Signal Transduct Res 24:85-105. 2004
    ..formation and growth of platelet aggregates and plaques in cardiovascular disorders, resulting in enhanced platelet adhesiveness and hyperaggregability, may serve in the generation of novel therapies in the treatment of inflammatory ..
  17. ncbi The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin
    G M Romo
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Exp Med 190:803-14. 1999
    ..Thus, the GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium...
  18. ncbi A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
    Ton Lisman
    Department of Biochemistry, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 108:3753-6. 2006
    ..23 either strongly interacted with both VWF and platelets or lacked both VWF and platelet binding. Thus, we identified the sequence RGQOGVMGF (O is hydroxyproline) as the minimal VWF-binding sequence in collagen III...
  19. ncbi Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria
    Guang Sun
    Departments of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Infect Immun 71:6553-61. 2003
    ..CD41 is not an adhesion molecule for parasitized erythrocytes, these findings support the hypothesis that inhibition of platelet adhesion to the brain microvasculature protects against development of malarial pathogenesis...
  20. ncbi F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Thromb Haemost 88:843-50. 2002
    ..Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke...
  21. ncbi Physical and enzymatic perturbation of the architecture of the Tunica media destroys its inherent thromboresistance
    Erzsebet Komorowicz
    Department of Medical Biochemsitry, Semmelweis University, Budapest, Hungary
    Thromb Haemost 88:827-33. 2002
    ..Collagen in the media may be complexed with another vessel wall component shielding the vWf-binding sites. Mechanical or biochemical processes unmask these sites, and increase the thrombogenicity of the vessel wall...
  22. ncbi Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura
    Fumiaki Banno
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 107:3161-6. 2006
    ..Alternatively, factors in addition to ADAMTS13 deficiency may be necessary for development of TTP...
  23. ncbi Salvianolic acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor alpha2beta1
    Ya Ping Wu
    Institute of Life Sciences, Taishan Medical University, Tai an, China
    Thromb Res 123:298-305. 2008
    ..These combined results indicate that SAB inhibits platelet adhesion to immobilized collagen by interfering with the collagen receptor alpha2beta1...
  24. ncbi The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis
    Jianchun Chen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 161:337-44. 2002
    ..The alpha(2)beta(1) integrin-null mouse thus exhibits diverse, sometimes subtle, phenotypes consistent with the widespread pattern of alpha(2)beta(1) integrin expression...
  25. ncbi Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    Owen J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
    J Biol Chem 280:39474-84. 2005
    ....
  26. ncbi Role of dystrophins and utrophins in platelet adhesion process
    Doris Cerecedo
    Dept Morfologia, Escuela Nacional de Ciencias Biologicas, IPN, D F Mexico
    Br J Haematol 134:83-91. 2006
    ..The simultaneous presence of dystrophin and utrophin complexes indicates complementary structural and signalling mechanisms to the actin network, improving the platelet haemostatic role...
  27. ncbi Adhesion of human platelets to albumin is synergistically increased by lysophosphatidic acid and adrenaline in a donor-dependent fashion
    Andreas C Eriksson
    Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linkoping University, Sweden
    Blood Coagul Fibrinolysis 17:359-68. 2006
    ..We also confirm that synergistic platelet activation achieved with LPA and adrenaline is highly donor dependent...
  28. ncbi Platelet adhesion: structural and functional diversity of short dystrophin and utrophins in the formation of dystrophin-associated-protein complexes related to actin dynamics
    Doris Cerecedo
    , , IPN,
    Thromb Haemost 94:1203-12. 2005
    ..Participation of both Dp71d/Dp71delta110m approximately DAPC and Up400/Up71 approximately DAPC in the biological roles of the platelets is discussed...
  29. ncbi Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo
    Sabine Grüner
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Blood 102:4021-7. 2003
    ..We conclude that shear-resistant platelet adhesion on the injured vessel wall in vivo is a highly integrated process involving multiple integrin-ligand interactions, none of which by itself is essential...
  30. ncbi Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion
    V Evangelista
    G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    J Thromb Haemost 1:1048-54. 2003
    ....
  31. ncbi Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion
    O J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Thromb Haemost 2:1823-33. 2004
    ..These results highlight a possible role for fibronectin in supporting thrombus formation...
  32. ncbi Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1
    Judith Lahav
    The Coagulation Laboratory, Rabin Medical Center Beilinson Campus, Zabotinski St, Petah Tiqva 49100, Israel
    Blood 102:2085-92. 2003
    ..These data suggest that the enzymatically catalyzed adhesion-associated reorganization of disulfide bonds is common to members of the integrin family and specific to this family...
  33. ncbi Inherited bleeding disorders: disorders of platelet adhesion and aggregation
    Indra Ramasamy
    Department of Chemical Pathology, Newham General Hospital, Glen Road, London E13 8RU, UK
    Crit Rev Oncol Hematol 49:1-35. 2004
    ..As progress advances towards individualisation of therapy the phenotypic bleeding tendency of each patient becomes relevant...
  34. ncbi Systemic antithrombotic effects of ADAMTS13
    Anil K Chauhan
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:767-76. 2006
    ..Our findings reveal that ADAMTS13 has a powerful natural antithrombotic activity and recombinant ADAMTS13 could be used as an antithrombotic agent...
  35. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis...
  36. ncbi von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively
    O J T McCarty
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 4:1367-78. 2006
    ..To accomplish this, VWF binds to two distinct platelet receptors: glycoprotein (GP)Ib-IX-V and integrin alpha(IIb)beta3...
  37. ncbi Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo
    Marijke J E Kuijpers
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    FASEB J 17:685-7. 2003
    ....
  38. ncbi Reduced high shear platelet adhesion to the vascular media: defective von Willebrand factor binding to the interstitial collagen
    Erzsebet Komorowic
    Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    Thromb Haemost 87:763-70. 2002
    ..Our data suggest that the media, despite its fibrillar collagen content, evidenced by electron microscopy, is defective for vWf-binding, which may explain its thromboresistant nature at high shear rates...
  39. ncbi Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate, Brooklyn 11203, USA
    Thromb Haemost 87:712-21. 2002
    ..The sequence of these functional domains of F11R (in the N-terminus and 1st Ig-fold) provide the basis for new drug development in the treatment of certain types of thrombocytopenia and inflammatory thrombosis...
  40. ncbi beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation
    Janine J J Hulstein
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 110:1483-91. 2007
    ..This mode of action could contribute to the thrombosis and consumptive thrombocytopenia observed in patients with anti-beta(2) GPI antibodies...
  41. ncbi Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
    ..These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential...
  42. ncbi Platelet-vessel wall interactions in atherosclerotic disease
    Harald F Langer
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Thromb Haemost 99:480-6. 2008
    ..Understanding interactions of platelets with other circulating cells and the vascular wall is a prerequisite to understand cardiovascular disease and to identify potential therapeutic targets...
  43. ncbi Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist
    Michelle A Berny
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 28:329-34. 2008
    ..The aim of this study was to delineate the molecular mechanism of direct WE-platelet interactions under static and shear conditions...
  44. ncbi Measurement of adhesion of human platelets in plasma to protein surfaces in microplates
    Andreas C Eriksson
    Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, , , Sweden
    J Pharmacol Toxicol Methods 52:356-65. 2005
    ..The assay is simple and flexible and is suitable in basic research for screening and characterisation of platelet adhesion responsiveness...
  45. ncbi Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 94:3829-38. 1999
    ..Since platelets are demonstrated here to induce tyrosine phosphorylation in endothelial cells, platelet recruitment might contribute to the development of an inflammatory reaction during I/R...
  46. ncbi Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets
    D A Law
    COR Therapeutics, Inc, South San Francisco, CA, USA
    Blood 93:2645-52. 1999
    ....
  47. ncbi A new perfusion chamber to detect platelet adhesion using a small volume of blood
    J J Sixma
    Department of Haematology, University Hospital, Utrecht, The Netherlands
    Thromb Res 92:S43-6. 1998
    ..Platelet adhesion under flow has also been studied with direct observation using this same chamber...
  48. ncbi Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    B Savage
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, La Jolla, California 92037, USA
    Cell 84:289-97. 1996
    ..This eventually allows activated alpha IIb beta 3 to arrest platelets onto vWF under conditions not permissive of direct binding to fibrinogen. The coupling of these different functions may be crucial for thrombogenesis...
  49. ncbi The presence of active von Willebrand factor under various pathological conditions
    Evelyn Groot
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands
    Curr Opin Hematol 14:284-9. 2007
    ..To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF...
  50. ncbi Two functional active conformations of the integrin {alpha}2{beta}1, depending on activation condition and cell type
    Gerlinde R Van De Walle
    Laboratories for Thrombosis Research, Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Campus Kortrijk, 8500 Kortrijk, Belgium
    J Biol Chem 280:36873-82. 2005
    ....
  51. ncbi Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'
    M T T Pennings
    Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Thromb Haemost 5:369-77. 2007
    ..Dimerized beta2GPI binds to apolipoprotein E receptor 2' (apoER2') on platelets and increases platelet adhesion to collagen under conditions of flow...
  52. ncbi Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin
    A K Chauhan
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 5:583-9. 2007
    ..Recent in vitro studies suggested that P-selectin might anchor these platelet strings to endothelium, but whether the same mechanism exists in vivo remains to be elucidated...
  53. ncbi Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
    Achim Obergfell
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:265-75. 2002
    ..These studies establish that platelet spreading on fibrinogen requires sequential activation of Src and Syk in proximity to alphaIIbbeta3, thus providing a paradigm for initiation of integrin signaling to the actin cytoskeleton...
  54. ncbi Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1)
    K Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    Blood 98:3708-16. 2001
    ....
  55. ncbi Glucocorticoids inhibit the cerebral microvascular dysfunction associated with sepsis in obese mice
    Vidula Vachharajani
    Critical Care Medicine, Louisiana State University Health Sciences Centre, Shreveport, Louisiana 71130, USA
    Microcirculation 13:477-87. 2006
    ..The objective of this study was to determine whether low-dose steroid therapy, which has proven effective in clinical setting, affords any benefit in the increased morbidity to sepsis in genetically obese (ob/ob) mice...
  56. ncbi Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment
    C P M Hayward
    McMaster University, Hamilton, Ontario, Canada
    Haemophilia 12:128-36. 2006
    ..Presently, there are a number of choices to consider for the management of bleeding symptoms, including menorrhagia. This paper reviews the causes, diagnostic evaluation and therapies for common and rare congenital platelet disorders...
  57. ncbi Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress
    A Bernardo
    Thrombosis Research Section, Department of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:562-70. 2005
    ..The observed phenomenon delineates a mechanism for leukocytes to be tethered to arterial endothelial cells under high shear, providing a potential link between inflammation and thrombosis...
  58. ncbi Contribution of distinct adhesive interactions to platelet aggregation in flowing blood
    Z M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, The Division of Experimental Hemostasis and Thrombosis, The Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 94:172-8. 1999
    ..The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes...
  59. ncbi Mechanisms initiating platelet thrombus formation
    Z M Ruggeri
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:611-6. 1997
    ....
  60. ncbi Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    P Andre
    Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 96:3322-8. 2000
    ..It is proposed that this process may rapidly recruit platelets to sites of injury or inflammation in veins...
  61. ncbi New concepts in von Willebrand disease
    J Evan Sadler
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Med 56:173-91. 2005
    ..Emerging data suggest that VWF level is a useful biomarker for the risk of either bleeding or thrombosis and could be incorporated into a comprehensive approach to treat or prevent these adverse events...
  62. ncbi The small proteoglycan decorin supports adhesion and activation of human platelets
    Gianni Guidetti
    Department of Biochemistry, University of Pavia, Italy
    Blood 100:1707-14. 2002
    ..Therefore, these results demonstrate that human platelets can bind to immobilized decorin through integrin alpha(2)beta(1), and that this interaction results in the tyrosine phosphorylation of intracellular proteins...
  63. ncbi Integrin tyrosine phosphorylation in platelet signaling
    D R Phillips
    COR Therapeutics, Inc, 256 East Grand Avenue, South San Francisco, California 94080, USA
    Curr Opin Cell Biol 13:546-54. 2001
    ..Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals...
  64. ncbi A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications
    Kesheng Dai
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 835 South Wolcott Ave, Chicago, IL 60612, USA
    Blood 106:1975-81. 2005
    ....
  65. ncbi Association of the antagonism of von Willebrand factor but not fibrinogen by platelet alphaIIbbeta3 antagonists with prolongation of bleeding time
    T Aoki
    Medicinal Biology, Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Kashima, Yodogawa ku, Osaka, Japan
    J Thromb Haemost 3:2307-14. 2005
    ..The present study investigates the correlation of inhibition of fibrinogen and von Willebrand factor (VWF) binding by alphaIIbbeta3 antagonists with the inhibition of platelet aggregation and prolongation of bleeding time (BT)...
  66. ncbi The role of the platelet in the pathogenesis of atherothrombosis
    Steven R Steinhubl
    The Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
    Am J Cardiovasc Drugs 5:399-408. 2005
    ..Elucidation of the multiple mechanisms involved in platelet thrombus formation provides opportunities for selectively inhibiting the pathways most relevant to the pathophysiology of atherothrombosis...
  67. ncbi Hemocompatibility of poly(ether imide) membranes functionalized with carboxylic groups
    R Tzoneva
    Institute of Biophysics, Bulgarian Academy of Sciences, Acad G Bonchev St, Bl 108, Sofia 1113, Bulgaria
    J Mater Sci Mater Med 19:3203-10. 2008
    ..However, overall the hemocompatibility of all PEI membranes was higher than that of PET...
  68. ncbi Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain
    Jaehyung Cho
    Molecular and Cellular Pharmacology Program and Department of Medicine, University of Wisconsin Madison School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 280:35490-8. 2005
    ..This interaction is less dominant when platelets adhere to fibrin, resulting in enhanced fibronectin assembly...
  69. ncbi ClfA(221-550), a fibrinogen-binding segment of Staphylococcus aureus clumping factor A, disrupts fibrinogen function
    Chao Zong Liu
    Department of Pharmacology, College of Medicine, Tzu Chi University, Hualien City, Hualien, Taiwan
    Thromb Haemost 94:286-94. 2005
    ....
  70. ncbi Influence of nanoporesize on platelet adhesion and activation
    Natalia Ferraz
    Department of Physical and Analytical Chemistry, Division of Surface Biotechnology, Uppsala University, BMC, Husarg 3, Box 577, Uppsala 751 23, Sweden
    J Mater Sci Mater Med 19:3115-21. 2008
    ..The study highlights the importance of understanding molecular and cellular events on nano-level when designing new biomaterials...
  71. ncbi Adhesive surface determines raft composition in platelets adhered under flow
    M Van Lier
    Laboratory for Thrombosis and Haemostasis, Department of Haematology, UMCU and Institute of Biomembranes, Utrecht, The Netherlands
    J Thromb Haemost 3:2514-25. 2005
    ..These data show that the adhesive substrate determines the composition of CRDs, and that cholesterol is crucial for redistribution of GPIbalpha but not of GPVI...
  72. ncbi Minding the gaps to promote thrombus growth and stability
    Lawrence F Brass
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:3385-92. 2005
    ....
  73. ncbi Platelet function under high-shear conditions from platelet concentrates
    Petra Jilma-Stohlawetz
    Department of Blood Group Serology and Transfusion Medicine and Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Transfusion 48:129-35. 2008
    ..Platelet (PLT) collection and storage affect the functional capacity of PLTs in PLT concentrates (PCs). Therefore, PLTs' functional quality should be studied before transfusion...
  74. ncbi Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease
    Christina Perneby
    Karolinska Institutet Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital, Stockholm, Sweden
    Thromb Haemost 98:1316-22. 2007
    ..Intensified antiplatelet treatment did not reduce ECG signs of either exercise-induced or ambulatory myocardial ischemia...
  75. ncbi Plasma-deposited tetraglyme surfaces greatly reduce total blood protein adsorption, contact activation, platelet adhesion, platelet procoagulant activity, and in vitro thrombus deposition
    Lan Cao
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 81:827-37. 2007
    ..The improved blood compatibility of plasma-deposited tetraglyme is thus not only due to their reduced platelet adhesion and activation, but also to a generalized reduction in blood interactions...
  76. ncbi Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide
    T David
    INSERM U311, Strasbourg EFS Alsace, Strasbourg, France
    J Thromb Haemost 4:2645-55. 2006
    ..This interaction also plays an important role in initiating platelet activation through the generation of intracellular signals resulting in platelet shape change and integrin alpha(IIb)beta3 activation...
  77. ncbi Preconditioning ischemia attenuates molecular indices of platelet activation-aggregation
    M D Linden
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Haemost 4:2670-7. 2006
    ..190% +/- 21% of baseline; *P < 0.05 and P = 0.09 vs. control). CONCLUSION: These data provide novel, direct evidence in support of the concept that ischemic PC attenuates molecular indices of platelet activation-aggregation...
  78. ncbi Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis
    Shaker A Mousa
    DuPont Pharmaceuticals Company, 141 and Henry Clay Road, Exp Station, E400 3470, Wilmington, DE 19880 0400, USA
    J Cardiovasc Pharmacol 39:552-60. 2002
    ....
  79. ncbi Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation
    Andreas Straub
    Dept of Thoracic, Cardiac and Vascular Surgery, University of Tubingen, Germany
    Thromb Haemost 99:609-15. 2008
    ..TGX-221 represents a promising alternative to GP IIb/IIIa blockade and should be further investigated for use during ECC in vivo...
  80. ncbi Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice
    Matt W Goschnick
    Burnet Institute Austin Research Institute, Studley Road, Heidelberg, Victoria 3084, Australia
    Blood 108:1911-8. 2006
    ..These data demonstrate that TSSC6 appears to regulate integrin alpha(IIb)beta(3) "outside-in" signaling events in platelets and is necessary for stability of arterial thrombi in vivo...
  81. ncbi Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio-material for platelet-rich plasma preparation
    E-Chin Shen
    Department of Periodontology, School of Dentistry, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
    Clin Oral Implants Res 17:572-8. 2006
    ..CONCLUSION: Because of the observations of growth factors releasing from activated human platelets after chitosan stimulation, we suggest that chitosan may be an appropriate substitute for thrombin in PRP preparation...
  82. ncbi Bacitracin reveals a role for multiple thiol isomerases in platelet function
    Aisling Robinson
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Br J Haematol 132:339-48. 2006
    ..Taken together, these studies support a role for the endogenous integrin thiol isomerase activity in activation of alphaIIb beta3 and highlight the novel regulation of platelet function by other, as yet undefined thiol isomerases...
  83. ncbi Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling
    Shinya Goto
    Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Coll Cardiol 47:155-62. 2006
    ..We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood...
  84. ncbi Molecular characterization of a human monoclonal antibody that interacts with a sulfated tyrosine-containing epitope of the GPIb receptor and inhibits platelet functions
    Yocheved Hagay
    Bio Technology General Israel Ltd, Research Department, Kiryat Weizmnn, Building 17, 76326 Rehovot, Israel
    Mol Immunol 43:443-53. 2006
    ..In conclusion, this unique antibody and mutants, that recognize a sulfated epitope in GP1b receptor, efficiently inhibited platelet adhesion and aggregation, making it a candidate for a new anti-thrombotic agent...
  85. ncbi Platelet secretion: indiscriminately spewed forth or highly orchestrated?
    G C White
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:2006-8. 2007
  86. ncbi Effects of a new pathogen-reduction technology (Mirasol PRT) on functional aspects of platelet concentrates
    S Perez-Pujol
    Hemotherapy-Hemostasis Service, CDB, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Transfusion 45:911-9. 2005
    ..CONCLUSION: PLT function was well preserved in PCs treated with 6.2 J per mL Mirasol PRT and stored for 5 days...
  87. ncbi Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI
    Sandra Penz
    Institute for Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany
    FASEB J 19:898-909. 2005
    ..This platelet collagen receptor, essential for plaque-induced thrombus formation, presents a promising new anti-thrombotic target for the prevention of ischemic cardiovascular diseases...
  88. ncbi Blood compatibility of titanium oxides with various crystal structure and element doping
    Manfred F Maitz
    Forschungszentrum Rossendorf, Institute for Ion Beam Physics and Materials Research, P O Box 51 01 19, 01314 Dresden, Germany
    J Biomater Appl 17:303-19. 2003
    ..But little is known about the influence of physical characteristics like crystal structure, roughness and electronic state on the activation of blood platelets and the blood clotting cascade...
  89. ncbi Hemocompatibility of titanium oxide films
    N Huang
    Institute of Biomaterials and Surface Engineering, School of Materials Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
    Biomaterials 24:2177-87. 2003
    ..It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved hemocompatibility...
  90. ncbi Plasma fibronectin promotes thrombus growth and stability in injured arterioles
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2415-9. 2003
    ....
  91. ncbi Effects of glycoprotein IIb/IIIa antagonists on platelet activation: development of a transfer method to mimic peak to trough receptor occupancy
    Jeffrey T Billheimer
    Bristol-Myers Squibb Company, Experimental Station E400/3253, Wilmington, DE 19880-0400, USA
    Thromb Res 107:303-17. 2002
    ..In conclusion, these studies do not provide evidence for an activation liability of GPIIb/IIIa antagonists in vitro...
  92. ncbi Dynamics of GPIIb/IIIa-mediated platelet-platelet interactions in platelet adhesion/thrombus formation on collagen in vitro as revealed by videomicroscopy
    Dipti Patel
    Laboratory of Blood and Vascular Biology, The Rockefeller University, New York, NY 10021, USA
    Blood 101:929-36. 2003
    ..Thus, in this model system, absence or blockade of GPIIb/IIIa receptors interferes with thrombus formation and alters the pattern of platelet deposition...
  93. ncbi Differential response of human and bovine platelets to bovine von Willebrand factor and vascular subendothelium
    G H Rao
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
    Platelets 12:150-5. 2001
    ..In contrast, bovine platelets in blood with low molecular weight heparin as anticoagulant adhered more readily than human cells. These findings suggest that different mechanisms are involved in hemostasis in human and bovine species...
  94. ncbi Pharmacological characteristics of solid-phase von Willebrand factor in human platelets
    A Radomski
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7 Canada
    Br J Pharmacol 134:1013-20. 2001
    ..12. Mechanisms of activation of GPIb by svWF involve the release of MMP-2, and are regulated by NO and prostacyclin...
  95. ncbi Role of von Willebrand factor in tumour cell-induced platelet aggregation: differential regulation by NO and prostacyclin
    P Jurasz
    Department of Pharmacology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Br J Pharmacol 134:1104-12. 2001
    ..10. Prostacyclin and NO inhibit TCIPA-sVWF-mediated platelet aggregation. The mechanisms of inhibition of this aggregation by PGI(2) differ from those of NO...
  96. ncbi Induction of platelet thrombi by bacteria and antibodies
    Ulf Sjöbring
    Section for Microbiology, Immunology and Glycobiology, the Institute of Laboratory Medicine, University of Lund, Lund, Sweden
    Blood 100:4470-7. 2002
    ....
  97. ncbi Structure and function of the von Willebrand factor A1 domain
    Kottayil I Varughese
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Curr Protein Pept Sci 3:301-12. 2002
    ..In this review, we present the current knowledge on the structural features of the VWF A1 domain that support its functions...
  98. ncbi Response to vWF-coated beads and soluble p-selectin to characterize apheresis platelets: a comparison of three cell separators
    Gabriele Stiegler
    Clinic for Blood Group Serology and Transfusion Medicine, University Hospital of Vienna, Austria
    Transfusion 42:375-9. 2002
    ..CONCLUSIONS: Different plateletpheresis procedures induced distinct changes of platelet function. Platelets collected using the Amicus DN retained the strongest adhesion capacity irrespective of their activation...
  99. ncbi Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist
    Yumiko Moritani
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
    Eur J Pharmacol 439:43-52. 2002
    ..It may be a promising antiplatelet agent for thromboembolic diseases, and a good prototype for developing an orally active compound...
  100. ncbi Shear-dependent tether formation during platelet translocation on von Willebrand factor
    Sacha M Dopheide
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill, Victoria, Australia
    Blood 99:159-67. 2002
    ....
  101. ncbi A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion
    C Perrault
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Thromb Haemost 86:1238-48. 2001
    ..This study suggests a role of GPIbbeta in modulating the adhesive properties of GPIb/V/IX and describes a useful tool to analyze the exact functions of GPIbbeta...

Research Grants106 found, 100 shown here

  1. Initiation and Regulation of Platelet Thrombus Formation
    ZAVERIO RUGGERI; Fiscal Year: 2004
    ..The results of the proposed studies will have an impact on public health by providing novel mechanistic information on processes that are central to normal hemostasis and pathological arterial thrombosis. ..
  2. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  3. Mechanisms of Thrombus Instability
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..These studies will provide novel insights into the unexpected role of leptin in platelet function, and in the formation and stability of thrombi. ..
  4. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  5. Role of von Willebrand Factor in Platelet Thrombus Formation
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..Understanding these different functions requires addressing structural details as well as verification of concepts in intravidal models. This will lead to a better diagnosis and treatment for cardio- and cerebro-vascular diseases. ..
  6. Platelet interactions with vessel wall components
    ZAVERIO RUGGERI; Fiscal Year: 2005
    ..These findings will provide a better definition and characterization of several potential targets for antithrombotic intervention that may yield new treatments for patients at risk of cardiovascular and cerebrovascular events. ..
  7. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  8. Thrombus Formation and Antithrombotic Intervention
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  9. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2007
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  10. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002
    ..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
  11. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2007
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease. Thus, giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  12. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2006
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  13. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2009
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..
  14. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
  15. Role of JAM Family in Angiogenesis
    Ulhas Naik; Fiscal Year: 2007
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a new line of investigation that is important in tumorigenesis and vascular biology. ..
  16. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..Characterizing the cell adhesion function of this novel protein will open up a new line of investigation that is important in inflammatory diseases and vascular biology. ..
  17. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2010
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..
  18. Proteolysis of ultralarge von Willebrand factor and metabolic syndrome-diabetes
    Jing Fei Dong; Fiscal Year: 2010
    ..Results of the study will help us to understand how defective ULVWF proteolysis contributes to the development of atherothrombosis associated with the syndrome. ..
  19. Characterization of coagulation factor-platelet interactions: role of FXI
    Owen J McCarty; Fiscal Year: 2010
    ..We propose that elucidation of the role that FXI plays in clot formation may provide the basis for the pharmaceutical development of such a novel class of FXI-targeted anti-thrombotics. ..
  20. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  21. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2003
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  22. YOUTH TAKE HEART (PHASE I & II)
    Buddy Ratner; Fiscal Year: 2007
    ..Youth Take Heart will help enhance the cardiovascular health and quality of life for numerous students through the teaching of medical management, prevention, and control of risk factors for heart disease. ..
  23. Regulation of vascular development and function by LKLF
    Mark L Kahn; Fiscal Year: 2010
    ..Understanding the mechanism by which LKLF regulates genetic responses in the developing and mature vasculature is expected to provide new insights into the pathogenesis and treatment of human vascular diseases. ..
  24. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
    ..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. ..
  25. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  26. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy Ratner; Fiscal Year: 2009
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  27. CELLULAR MODULATION OF MICROVESSEL PERMEABILITY IN VIVO
    Pingnian He; Fiscal Year: 2009
    ..A better understanding of the mechanisms that regulate microvessel permeability is crucial to defining the pathogenesis of many disease conditions, and to aid in the development of novel therapeutic approaches. ..
  28. Reaction and Transport Dynamics in Human Blood
    Scott Diamond; Fiscal Year: 2009
    ..Overall, these studies seek to provide fundamental insight into cell-cell interacitions and coagulation biochemistry that occur under flow. ..
  29. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2010
    ..Our work will be of great value for a better understanding of these processes in platelets and other cells, such as leukocytes or neurons, and it may lead to the identification of novel targets for antiplatelet therapy. ..
  30. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy D Ratner; Fiscal Year: 2010
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  31. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Donald L Trump; Fiscal Year: 2010
    ..We also propose to examine molecular changes in tumor tissue after therapy which could significantly impact the design of the proposed therapeutic approach. ..
  32. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Candace Johnson; Fiscal Year: 2009
    ..We also propose to examine molecular changes in tumor tissue after therapy which could significantly impact the design of the proposed therapeutic approach. ..
  33. ANTITUMOR MECHANISMS & THERAPEUTIC EFFECTS OF VITAMIN D
    Candace Johnson; Fiscal Year: 2002
    ....
  34. MECHANISMS OF NONVIRAL CARDIOVASCULAR GENE TRANSFER
    Scott Diamond; Fiscal Year: 2004
    ..Overall, these studies will investigate the delivery of plasmids to the nucleus of nondividing endothelium or smooth muscle cells in order to improve nonviral gene transfer. ..
  35. Platelet Liposomal Drug Delivery--Thrombosis /Restenosis
    Shuwu Wang; Fiscal Year: 2006
    ..The targeted liposomal system proposed could reduce the costs in both treatment areas with a 5% reduction in revascularizations alone leading to >$60 million annual medical cost savings. ..
  36. REACTION AND TRANSPORT DYNAMICS DURING THROMBOLYSIS
    Scott Diamond; Fiscal Year: 1999
    ..Overall, the understanding of spatial dynamics in dissolving thrombi will help facilitate the rational design and optimization of lytic therapy, particularly those approaches involving catheters or combined therapeutic agents. ..
  37. 1st International Symposium on Wound Healing and Technology (WHAT I)
    Buddy Ratner; Fiscal Year: 2006
    ..Communication and discussion of these problems and new ideas for how we can address them are central to this meeting. ..
  38. Mechanisms of Cardiopulmonary Gene Transfer
    Scott Diamond; Fiscal Year: 2007
    ..Overall, these bioengineering studies will focus on barriers/rate limits that prevent high efficiency gene transfer. ..
  39. High Intensity Ultrasound in Gastroenterology
    JOO HWANG; Fiscal Year: 2003
    ..It is anticipated that this work will help to gain a better understanding of the mechanisms of HIFU and its potential role for other GI applications such as tumor therapy. ..
  40. Biomimetic Coatings for Small Diameter Vascular Grafts
    Shuwu Wang; Fiscal Year: 2004
    ..We anticipate that this project will lead to highly effective biomimetic materials that facilitate shear stable modification of small diameter vascular prostheses that demonstrate improved blood compatibility. ..
  41. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy Ratner; Fiscal Year: 2007
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  42. Training in Engineered Biomaterials
    Buddy Ratner; Fiscal Year: 2007
    ..Trainees will participate in the training program for a period of 2 years. ..
  43. Streptococcus-Candida Communication in Oral Biofilms
    HOWARD JENKINSON; Fiscal Year: 2007
    ..albicans overgrowth. Candida yeast infections are a serious threat to public health. This research devises new methods for controlling or preventing growth of Candida in the mouth. ..
  44. Ultrasound induced vessel thrombosis for treatment of Gastric varices
    JOO HWANG; Fiscal Year: 2007
    ..This method can be translated to a clinically useful approach for the treatment of gastric varices with the development of an endoscopic-based ultrasound transducer ..