platelet adhesiveness

Summary

Summary: The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.

Top Publications

  1. doi Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor
    Daisuke Mori
    Department of Bioengineering and Robotics, Tohoku University, 6 6 01 Aoba, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Thromb Haemost 99:108-15. 2008
  2. doi New insights into the haemostatic function of platelets
    Andrew H Wei
    The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
    Br J Haematol 147:415-30. 2009
  3. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
  4. pmc Antithrombogenic modification of small-diameter microfibrous vascular grafts
    Craig K Hashi
    University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 30:1621-7. 2010
  5. ncbi The small proteoglycan decorin supports adhesion and activation of human platelets
    Gianni Guidetti
    Department of Biochemistry, University of Pavia, Italy
    Blood 100:1707-14. 2002
  6. pmc Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts
    Craig K Hashi
    Department of Bioengineering and Center for Tissue Bioengineering, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:11915-20. 2007
  7. ncbi Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia
    José A Barrabés
    Department of Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Am Coll Cardiol 45:293-9. 2005
  8. ncbi Mechanisms initiating platelet thrombus formation
    Z M Ruggeri
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:611-6. 1997
  9. ncbi Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    B Savage
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, La Jolla, California 92037, USA
    Cell 84:289-97. 1996
  10. ncbi Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III
    Nicolas Raynal
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:3821-31. 2006

Research Grants

  1. Role of von Willebrand Factor in Platelet Thrombus Formation
    Zaverio M Ruggeri; Fiscal Year: 2010
  2. Mechanisms of Thrombus Instability
    ZAVERIO RUGGERI; Fiscal Year: 2007
  3. Thrombus Formation and Antithrombotic Intervention
    ZAVERIO RUGGERI; Fiscal Year: 2007
  4. Platelet interactions with vessel wall components
    ZAVERIO RUGGERI; Fiscal Year: 2005
  5. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
  6. Initiation and Regulation of Platelet Thrombus Formation
    ZAVERIO RUGGERI; Fiscal Year: 2004
  7. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
  8. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
  9. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
  10. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010

Detail Information

Publications207 found, 100 shown here

  1. doi Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor
    Daisuke Mori
    Department of Bioengineering and Robotics, Tohoku University, 6 6 01 Aoba, Aoba ku, Sendai, Miyagi 980 8579, Japan
    Thromb Haemost 99:108-15. 2008
    ....
  2. doi New insights into the haemostatic function of platelets
    Andrew H Wei
    The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
    Br J Haematol 147:415-30. 2009
    ....
  3. ncbi Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets
    Peter A Smethurst
    Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, United Kingdom
    J Biol Chem 282:1296-304. 2007
    ..Furthermore, we propose that the (GPO)4 motif can support simultaneous binding of two glycoprotein VI molecules, in either a parallel or anti-parallel stacking arrangement, which could play an important role in activation of signaling...
  4. pmc Antithrombogenic modification of small-diameter microfibrous vascular grafts
    Craig K Hashi
    University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 30:1621-7. 2010
    ..To develop small-diameter vascular grafts with a microstructure similar to native matrix fibers and with chemically modified microfibers to prevent thrombosis...
  5. ncbi The small proteoglycan decorin supports adhesion and activation of human platelets
    Gianni Guidetti
    Department of Biochemistry, University of Pavia, Italy
    Blood 100:1707-14. 2002
    ..Therefore, these results demonstrate that human platelets can bind to immobilized decorin through integrin alpha(2)beta(1), and that this interaction results in the tyrosine phosphorylation of intracellular proteins...
  6. pmc Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts
    Craig K Hashi
    Department of Bioengineering and Center for Tissue Bioengineering, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:11915-20. 2007
    ..These results demonstrate several favorable characteristics of nanofibrous scaffolds, the excellent patency of small-diameter nanofibrous vascular grafts, and the unique antithrombogenic property of MSCs...
  7. ncbi Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia
    José A Barrabés
    Department of Cardiologia, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Am Coll Cardiol 45:293-9. 2005
    ..The goal of this study was to assess whether selectin blockade reduces myocardial platelet deposition and platelet-mediated injury after transient ischemia...
  8. ncbi Mechanisms initiating platelet thrombus formation
    Z M Ruggeri
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Thromb Haemost 78:611-6. 1997
    ....
  9. ncbi Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    B Savage
    Roon Research Center for Arteriosclerosis and Thrombosis, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, La Jolla, California 92037, USA
    Cell 84:289-97. 1996
    ..This eventually allows activated alpha IIb beta 3 to arrest platelets onto vWF under conditions not permissive of direct binding to fibrinogen. The coupling of these different functions may be crucial for thrombogenesis...
  10. ncbi Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III
    Nicolas Raynal
    Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 281:3821-31. 2006
    ..We describe two novel high affinity integrin-binding motifs in human collagen III (GROGER and GLOGEN) and a third motif (GLKGEN) that displays intermediate activity. Each motif was verified using shorter synthetic peptides...
  11. ncbi Platelets express functional Toll-like receptor-4
    Graciela Andonegui
    Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada
    Blood 106:2417-23. 2005
    ..Thus, our data show for the first time that platelets do express functional levels of TLR4, which contribute to thrombocytopenia through neutrophil-dependent pulmonary sequestration in response to LPS...
  12. pmc Activation-independent platelet adhesion and aggregation under elevated shear stress
    Zaverio M Ruggeri
    The Scripps Research Institute MEM 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 108:1903-10. 2006
    ..Platelet and VWF modulation by hydrodynamic force is a mechanism for activation-independent aggregation that may support thrombotic arterial occlusion...
  13. ncbi Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 92:507-15. 1998
    ..Platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury...
  14. pmc von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models
    Alexander Brill
    Immune Disease Institute, 3 Blackfan Circle, Boston, MA 02115, USA
    Blood 117:1400-7. 2011
    ..Our results demonstrate a pathogenetic role for VWF-platelet interaction in flow disturbance-induced venous thrombosis...
  15. pmc Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)
    Tara C White-Adams
    Division of Biomedical Engineering, Oregon Health and Science University School of Medicine, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 29:1602-7. 2009
    ..The aim of this study was to investigate the mechanisms governing interactions between FXI and platelets...
  16. ncbi Platelet collagen receptors, signaling and antagonism: emerging approaches for the prevention of intravascular thrombosis
    William Rasican Surin
    Cardiovascular Pharmacology Unit, Central Drug Research Institute, Lucknow 226001, India
    Thromb Res 122:786-803. 2008
    ..These findings have revealed that collagen receptor inhibition is an attractive and secure strategy for the new drug development to prevent intravascular thrombosis...
  17. ncbi Glow discharge plasma treatment of polyethylene tubing with tetraglyme results in ultralow fibrinogen adsorption and greatly reduced platelet adhesion
    Lan Cao
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 79:788-803. 2006
    ..The improved hemocompatibility is attributed to the unique chemical structure of RFGD tetraglyme that makes it highly protein resistant...
  18. ncbi Inherited bleeding disorders: disorders of platelet adhesion and aggregation
    Indra Ramasamy
    Department of Chemical Pathology, Newham General Hospital, Glen Road, London E13 8RU, UK
    Crit Rev Oncol Hematol 49:1-35. 2004
    ..As progress advances towards individualisation of therapy the phenotypic bleeding tendency of each patient becomes relevant...
  19. doi VEGF-E enhances endothelialization and inhibits thrombus formation on polymeric surfaces
    Menno L W Knetsch
    Centre for Biomaterials Research, University of Maastricht, Maastricht, The Netherlands
    J Biomed Mater Res A 93:77-85. 2010
    ..Adsorption of VEGF-E, especially on heparin containing surfaces, provides an economical strategy to improve endothelialization of cardiovascular implants without disturbing blood-compatibility...
  20. pmc In vivo performance of a phospholipid-coated bioerodable elastomeric graft for small-diameter vascular applications
    Lorenzo Soletti
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biomed Mater Res A 96:436-48. 2011
    ..Further evaluation in vivo will be required to demonstrate complete remodeling of the graft into a native-like artery...
  21. ncbi Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets
    D A Law
    COR Therapeutics, Inc, South San Francisco, CA, USA
    Blood 93:2645-52. 1999
    ....
  22. doi Low thrombogenicity coating of nonwoven PET fiber structures for vascular grafts
    Sashka Dimitrievska
    Industrial Materials Institute, National Research Council Canada, 75 de Mortagne, Boucherville, QC J4B6Y4, Canada
    Macromol Biosci 11:493-502. 2011
    ....
  23. doi Super hydrophilic thin film nitinol demonstrates reduced platelet adhesion compared with commercially available endograft materials
    Allan W Tulloch
    Department of Surgery, Division of Vascular Surgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90025, USA
    J Surg Res 171:317-22. 2011
    ....
  24. ncbi Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo
    S Massberg
    Ludwig Maximilians University, Institute for Surgical Research, Klinikum Grosshadern, Munich, Germany
    Blood 94:3829-38. 1999
    ..Since platelets are demonstrated here to induce tyrosine phosphorylation in endothelial cells, platelet recruitment might contribute to the development of an inflammatory reaction during I/R...
  25. ncbi F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Thromb Haemost 88:843-50. 2002
    ..Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke...
  26. ncbi Formation of viscoelastic protein layers on polymeric surfaces relevant to platelet adhesion
    Norbert Weber
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, USA
    J Biomed Mater Res A 72:420-7. 2005
    ..These results suggest that material-dependent changes in the thickness and viscoelastic properties of adsorbed fibrinogen-GPIIb-IIIa layers are crucial factors in the binding behavior of platelets to biomaterials...
  27. ncbi Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions
    Gertie J Oostingh
    University of Wurzburg, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg Germany
    Haematologica 92:502-12. 2007
    ..P-selectin ctin has been implicated in important platelet functions. However, neither its role in thrombus formation and cardiovascular disorders nor its suitability as a therapeutic target structure is entirely clear...
  28. ncbi The effect of surface roughness on activation of the coagulation system and platelet adhesion in rotary blood pumps
    Jörg Linneweber
    Klinik für Kardiovaskuläre Chirurgie, Charite Universitatsmedizin Berlin, Berlin, Germany
    Artif Organs 31:345-51. 2007
    ..By contrast, the surface roughness had no significant influence on plasma prothrombin F1.2 fragment- and TAT concentrations. Antithrombogenicity was significantly reduced in pumps with inferior metal-finishing quality...
  29. pmc A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    Steffen Massberg
    Deutsches Herzzentrum und 1 Medizinische Klinik, Technische Universitat Munchen, Germany
    J Exp Med 196:887-96. 2002
    ..These findings establish the platelet as a major player in initiation of the atherogenetic process...
  30. doi A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion
    Yung Chang
    R and D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong Li, Taoyuan 320, Taiwan
    Langmuir 24:5453-8. 2008
    ..This work further concludes that a surface with good hemocompatibility can be achieved by the well-packed surface-grafted polySBMA brushes...
  31. ncbi Glycocalyx-mimetic dextran-modified poly(vinyl amine) surfactant coating reduces platelet adhesion on medical-grade polycarbonate surface
    A Sen Gupta
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biomaterials 27:3084-95. 2006
    ..The results suggest potential application of carbohydrate-modified surfactant polymers as a glycocalyx-mimetic non-thrombogenic interfacial coating for blood-contacting biomaterials...
  32. doi Blood coagulation on biomaterials requires the combination of distinct activation processes
    Claudia Sperling
    Max Bergmann Center of Biomaterials Dresden, Leibniz Institute of Polymer Research Dresden, Dresden, Germany
    Biomaterials 30:4447-56. 2009
    ..Successful surface design strategies for hemocompatible materials therefore need to carefully consider the interplay of both processes...
  33. pmc The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis
    Jianchun Chen
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 161:337-44. 2002
    ..The alpha(2)beta(1) integrin-null mouse thus exhibits diverse, sometimes subtle, phenotypes consistent with the widespread pattern of alpha(2)beta(1) integrin expression...
  34. pmc Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading
    Marketa Jirouskova
    Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY 10021, USA
    Blood 109:5260-9. 2007
    ..We conclude that 2 fundamentally different signaling mechanisms can be initiated by a single integrin receptor interacting with the same ligand when it is immobilized at different densities...
  35. pmc Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
    H Ni
    The Center for Blood Research, Boston, Massachusetts 02115, USA
    J Clin Invest 106:385-92. 2000
    ..Platelets of these doubly deficient mice specifically accumulated fibronectin in their alpha-granules, suggesting that fibronectin could be the ligand supporting the platelet aggregation...
  36. ncbi A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
    Ton Lisman
    Department of Biochemistry, Downing Site, Cambridge CB2 1QW, United Kingdom
    Blood 108:3753-6. 2006
    ..23 either strongly interacted with both VWF and platelets or lacked both VWF and platelet binding. Thus, we identified the sequence RGQOGVMGF (O is hydroxyproline) as the minimal VWF-binding sequence in collagen III...
  37. ncbi Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa
    Malgorzata B Sobocka
    Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    J Recept Signal Transduct Res 24:85-105. 2004
    ..formation and growth of platelet aggregates and plaques in cardiovascular disorders, resulting in enhanced platelet adhesiveness and hyperaggregability, may serve in the generation of novel therapies in the treatment of inflammatory ..
  38. doi Platelets contribute to postnatal occlusion of the ductus arteriosus
    Katrin Echtler
    Deutsches Herzzentrum, Klinik für Herz und Kreislauferkrankungen, Technische Universitat, Munich, Germany
    Nat Med 16:75-82. 2010
    ..A retrospective clinical study revealed that thrombocytopenia is an independent predictor for failure of DA closure in preterm human newborns, indicating that platelets are likely to contribute to DA closure in humans...
  39. ncbi Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex
    Christelle Perrault
    INSERM U311, Etablissement Français du Sang, Alsace, Strasbourg, France
    Blood 101:3477-84. 2003
    ....
  40. pmc Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2
    Osamu Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Cell Biol 160:769-80. 2003
    ....
  41. doi Time sequence of blood activation by nanoporous alumina: Studies on platelets and complement system
    Natalia Ferraz
    Department of Physical and Analytical Chemistry, BMC, Uppsala University, Sweden
    Microsc Res Tech 73:1101-9. 2010
    ..The surface topography of the alumina most probably influence protein transition rate, which in turn affects material platelet activation kinetics...
  42. pmc The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
    ..Thus, GPIbalpha contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF...
  43. ncbi Activation of platelets adhered on amorphous hydrogenated carbon (a-C:H) films synthesized by plasma immersion ion implantation-deposition (PIII-D)
    P Yang
    Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong, Kowloon, China
    Biomaterials 24:2821-9. 2003
    ..The results show that the behavior of the platelets adhered on the a-C:H films is influenced by their structure and chemical bond, and it appears that protein interaction plays a key role in the activation of the adherent platelets...
  44. ncbi Hemocompatibility of materials used in microelectromechanical systems: platelet adhesion and morphology in vitro
    Brian A Weisenberg
    University of Minnesota, The Biomedical Engineering Institute, Minneapolis, Minnesota 55455, USA
    J Biomed Mater Res 60:283-91. 2002
    ..These results may be helpful in guiding the selection of materials for use in the development of blood-contacting microelectromechanical systems...
  45. pmc Inhibition of platelet adherence to brain microvasculature protects against severe Plasmodium berghei malaria
    Guang Sun
    Departments of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Infect Immun 71:6553-61. 2003
    ..CD41 is not an adhesion molecule for parasitized erythrocytes, these findings support the hypothesis that inhibition of platelet adhesion to the brain microvasculature protects against development of malarial pathogenesis...
  46. ncbi Contribution of distinct adhesive interactions to platelet aggregation in flowing blood
    Z M Ruggeri
    Roon Research Center for Arteriosclerosis and Thrombosis, The Division of Experimental Hemostasis and Thrombosis, The Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 94:172-8. 1999
    ..The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes...
  47. ncbi Contribution of platelet-derived factor Va to thrombin generation on immobilized collagen- and fibrinogen-adherent platelets
    J J Briedé
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Thromb Haemost 85:509-13. 2001
    ..Our findings suggest a unique role for immobilized collagen in maintaining haemostasis...
  48. pmc Plasma fibronectin promotes thrombus growth and stability in injured arterioles
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:2415-9. 2003
    ....
  49. ncbi Modification of Si(100) surface by the grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion
    F Zhang
    Department of Chemical Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Biomed Mater Res 56:324-32. 2001
    ..The grafted PEGMA polymer layer on the Si(100) surface exhibited fairly good stability during storage in a buffer solution...
  50. pmc The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin
    G M Romo
    Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Exp Med 190:803-14. 1999
    ..Thus, the GP Ib-IX-V complex mediates platelet attachment to both subendothelium and activated endothelium...
  51. doi Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
    T C White
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Thromb Haemost 6:995-1002. 2008
    ..Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if protein C interacts with cells in an alternative manner...
  52. ncbi Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    P Andre
    Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 96:3322-8. 2000
    ..It is proposed that this process may rapidly recruit platelets to sites of injury or inflammation in veins...
  53. pmc Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow
    Mario Mazzucato
    Department of Laboratory Medicine, Centro di Riferimento Oncologico CRO National Cancer Institute, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Aviano PN, Italy
    Blood 114:2793-801. 2009
    ..Our results delineate a GPVI-independent signaling role of alpha2beta1 in response to collagen stimulation...
  54. doi Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration
    Kristin N Kornerup
    Sackler Institute of Pulmonary Pharmacology and Therapeutics, Division of Pharmaceutical Sciences, School of Biomedical and Health Sciences, King s College, London, UK
    J Appl Physiol (1985) 109:758-67. 2010
    ..Targeting this interaction may be a successful strategy for inflammatory conditions where current therapy fails to provide adequate treatment...
  55. pmc Using microcontact printing of fibrinogen to control surface-induced platelet adhesion and activation
    Lindsey E Corum
    Department of Bioengineering, University of Utah, 20 South 2030 East, Salt Lake City, Utah 84112, USA
    Langmuir 27:8316-22. 2011
    ..Increasing the overall fibrinogen coverage resulted in higher activation levels defined by key morphological characteristics of the spreading platelet...
  56. ncbi The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques
    Anna Babinska
    Department of Anatomy Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Thromb Haemost 97:272-81. 2007
    ....
  57. doi Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization
    B Hechler
    UMR S949 INSERM, Universite de Strasbourg, Etablissement Francais du Sang Alsace, Strasbourg, France
    J Thromb Haemost 8:173-84. 2010
    ..Both types of lesion were sensitive to platelet GPIIb-IIIa and P2Y(12) inhibition, whereas only deep injuries were sensitive to thrombin blockade...
  58. ncbi Congenital platelet disorders: overview of their mechanisms, diagnostic evaluation and treatment
    C P M Hayward
    McMaster University, Hamilton, Ontario, Canada
    Haemophilia 12:128-36. 2006
    ..Presently, there are a number of choices to consider for the management of bleeding symptoms, including menorrhagia. This paper reviews the causes, diagnostic evaluation and therapies for common and rare congenital platelet disorders...
  59. ncbi Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion
    O J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Thromb Haemost 2:1823-33. 2004
    ..These results highlight a possible role for fibronectin in supporting thrombus formation...
  60. ncbi Measurement of adhesion of human platelets in plasma to protein surfaces in microplates
    Andreas C Eriksson
    Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    J Pharmacol Toxicol Methods 52:356-65. 2005
    ..The aim of this work was to develop a method to measure adhesion of platelets in plasma with standard laboratory equipment...
  61. ncbi Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura
    Fumiaki Banno
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 107:3161-6. 2006
    ..Alternatively, factors in addition to ADAMTS13 deficiency may be necessary for development of TTP...
  62. ncbi von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively
    O J T McCarty
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 4:1367-78. 2006
    ..To accomplish this, VWF binds to two distinct platelet receptors: glycoprotein (GP)Ib-IX-V and integrin alpha(IIb)beta3...
  63. ncbi Two functional active conformations of the integrin {alpha}2{beta}1, depending on activation condition and cell type
    Gerlinde R Van De Walle
    Laboratories for Thrombosis Research, Interdisciplinary Research Centre, Katholieke Universiteit Leuven, Campus Kortrijk, 8500 Kortrijk, Belgium
    J Biol Chem 280:36873-82. 2005
    ....
  64. pmc Platelet adhesion: structural and functional diversity of short dystrophin and utrophins in the formation of dystrophin-associated-protein complexes related to actin dynamics
    Doris Cerecedo
    Departamento Morfología, Escuela Nacional de Ciencias Biologicas, IPN, D F, Mexico
    Thromb Haemost 94:1203-12. 2005
    ..Participation of both Dp71d/Dp71delta110m approximately DAPC and Up400/Up71 approximately DAPC in the biological roles of the platelets is discussed...
  65. ncbi Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin
    A K Chauhan
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 5:583-9. 2007
    ..Recent in vitro studies suggested that P-selectin might anchor these platelet strings to endothelium, but whether the same mechanism exists in vivo remains to be elucidated...
  66. ncbi Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'
    M T T Pennings
    Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Thromb Haemost 5:369-77. 2007
    ..Dimerized beta2GPI binds to apolipoprotein E receptor 2' (apoER2') on platelets and increases platelet adhesion to collagen under conditions of flow...
  67. pmc Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    Owen J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
    J Biol Chem 280:39474-84. 2005
    ....
  68. pmc Systemic antithrombotic effects of ADAMTS13
    Anil K Chauhan
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:767-76. 2006
    ..Our findings reveal that ADAMTS13 has a powerful natural antithrombotic activity and recombinant ADAMTS13 could be used as an antithrombotic agent...
  69. ncbi Adhesion of human platelets to albumin is synergistically increased by lysophosphatidic acid and adrenaline in a donor-dependent fashion
    Andreas C Eriksson
    Division of Pharmacology, Department of Medicine and Care, Faculty of Health Sciences, Linkoping University, Sweden
    Blood Coagul Fibrinolysis 17:359-68. 2006
    ..We also confirm that synergistic platelet activation achieved with LPA and adrenaline is highly donor dependent...
  70. ncbi Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress
    A Bernardo
    Thrombosis Research Section, Department of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:562-70. 2005
    ..The observed phenomenon delineates a mechanism for leukocytes to be tethered to arterial endothelial cells under high shear, providing a potential link between inflammation and thrombosis...
  71. ncbi Role of dystrophins and utrophins in platelet adhesion process
    Doris Cerecedo
    Dept Morfologia, Escuela Nacional de Ciencias Biologicas, IPN, D F Mexico
    Br J Haematol 134:83-91. 2006
    ..The simultaneous presence of dystrophin and utrophin complexes indicates complementary structural and signalling mechanisms to the actin network, improving the platelet haemostatic role...
  72. ncbi Glucocorticoids inhibit the cerebral microvascular dysfunction associated with sepsis in obese mice
    Vidula Vachharajani
    Critical Care Medicine, Louisiana State University Health Sciences Centre, Shreveport, Louisiana 71130, USA
    Microcirculation 13:477-87. 2006
    ..The objective of this study was to determine whether low-dose steroid therapy, which has proven effective in clinical setting, affords any benefit in the increased morbidity to sepsis in genetically obese (ob/ob) mice...
  73. ncbi A new perfusion chamber to detect platelet adhesion using a small volume of blood
    J J Sixma
    Department of Haematology, University Hospital, Utrecht, The Netherlands
    Thromb Res 92:S43-6. 1998
    ..Platelet adhesion under flow has also been studied with direct observation using this same chamber...
  74. ncbi The presence of active von Willebrand factor under various pathological conditions
    Evelyn Groot
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, The Netherlands
    Curr Opin Hematol 14:284-9. 2007
    ..To highlight mechanisms that regulate the balance between latent and active von Willebrand factor (VWF), and describe pathological conditions leading to increased levels of active VWF...
  75. ncbi Platelet-collagen interaction: is GPVI the central receptor?
    Bernhard Nieswandt
    Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine Versbacher, Wurzburg, Germany
    Blood 102:449-61. 2003
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis...
  76. ncbi Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist
    Michelle A Berny
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 28:329-34. 2008
    ..The aim of this study was to delineate the molecular mechanism of direct WE-platelet interactions under static and shear conditions...
  77. ncbi Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo
    Marijke J E Kuijpers
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    FASEB J 17:685-7. 2003
    ....
  78. doi Platelet-vessel wall interactions in atherosclerotic disease
    Harald F Langer
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Thromb Haemost 99:480-6. 2008
    ..Understanding interactions of platelets with other circulating cells and the vascular wall is a prerequisite to understand cardiovascular disease and to identify potential therapeutic targets...
  79. doi Salvianolic acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor alpha2beta1
    Ya Ping Wu
    Institute of Life Sciences, Taishan Medical University, Tai an, China
    Thromb Res 123:298-305. 2008
    ..These combined results indicate that SAB inhibits platelet adhesion to immobilized collagen by interfering with the collagen receptor alpha2beta1...
  80. ncbi Physical and enzymatic perturbation of the architecture of the Tunica media destroys its inherent thromboresistance
    Erzsebet Komorowicz
    Department of Medical Biochemsitry, Semmelweis University, Budapest, Hungary
    Thromb Haemost 88:827-33. 2002
    ..Collagen in the media may be complexed with another vessel wall component shielding the vWf-binding sites. Mechanical or biochemical processes unmask these sites, and increase the thrombogenicity of the vessel wall...
  81. pmc Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
    Achim Obergfell
    Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 157:265-75. 2002
    ..These studies establish that platelet spreading on fibrinogen requires sequential activation of Src and Syk in proximity to alphaIIbbeta3, thus providing a paradigm for initiation of integrin signaling to the actin cytoskeleton...
  82. ncbi Reduced high shear platelet adhesion to the vascular media: defective von Willebrand factor binding to the interstitial collagen
    Erzsebet Komorowic
    Section of Hematology Research, Mayo Clinic and Foundation for Education and Research, Rochester, MN 55905, USA
    Thromb Haemost 87:763-70. 2002
    ..Our data suggest that the media, despite its fibrillar collagen content, evidenced by electron microscopy, is defective for vWf-binding, which may explain its thromboresistant nature at high shear rates...
  83. ncbi Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1)
    K Suzuki-Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi, Japan
    Blood 98:3708-16. 2001
    ....
  84. ncbi Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion
    Anna Babinska
    Department of Anatomy Cell Biology, State University of New York, Downstate, Brooklyn 11203, USA
    Thromb Haemost 87:712-21. 2002
    ..The sequence of these functional domains of F11R (in the N-terminus and 1st Ig-fold) provide the basis for new drug development in the treatment of certain types of thrombocytopenia and inflammatory thrombosis...
  85. pmc Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen
    B Nieswandt
    Department of Molecular Oncology, General Surgery, Witten Herdecke University, 42117 Wuppertal, Germany
    EMBO J 20:2120-30. 2001
    ..These data show that GPVI plays the central role in platelet-collagen interactions by activating different adhesive receptors, including alpha2beta1 integrin, which strengthens adhesion without being essential...
  86. ncbi beta2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation
    Janine J J Hulstein
    Laboratory for Thrombosis and Haemostasis, Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 110:1483-91. 2007
    ..This mode of action could contribute to the thrombosis and consumptive thrombocytopenia observed in patients with anti-beta(2) GPI antibodies...
  87. ncbi Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo
    Sabine Grüner
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Blood 102:4021-7. 2003
    ..We conclude that shear-resistant platelet adhesion on the injured vessel wall in vivo is a highly integrated process involving multiple integrin-ligand interactions, none of which by itself is essential...
  88. ncbi Role of P-selectin, beta2-integrins, and Src tyrosine kinases in mouse neutrophil-platelet adhesion
    V Evangelista
    G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    J Thromb Haemost 1:1048-54. 2003
    ....
  89. ncbi Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1
    Judith Lahav
    The Coagulation Laboratory, Rabin Medical Center Beilinson Campus, Zabotinski St, Petah Tiqva 49100, Israel
    Blood 102:2085-92. 2003
    ..These data suggest that the enzymatically catalyzed adhesion-associated reorganization of disulfide bonds is common to members of the integrin family and specific to this family...
  90. ncbi New concepts in von Willebrand disease
    J Evan Sadler
    Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Med 56:173-91. 2005
    ..Emerging data suggest that VWF level is a useful biomarker for the risk of either bleeding or thrombosis and could be incorporated into a comprehensive approach to treat or prevent these adverse events...
  91. ncbi Integrin tyrosine phosphorylation in platelet signaling
    D R Phillips
    COR Therapeutics, Inc, 256 East Grand Avenue, South San Francisco, California 94080, USA
    Curr Opin Cell Biol 13:546-54. 2001
    ..Platelets from mice lacking beta 3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of beta 3-integrin signals...
  92. doi N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets
    Elsa Lanke
    Department for Coagulation Disorders, University Hospital, Malmo, Sweden
    Eur J Haematol 81:384-90. 2008
    ..Our findings indicate that the N1421K substitution in the VWF affects the GPIb binding site or a recognition element by a conformational change of the A1 domain...
  93. ncbi Bacitracin reveals a role for multiple thiol isomerases in platelet function
    Aisling Robinson
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Br J Haematol 132:339-48. 2006
    ..Taken together, these studies support a role for the endogenous integrin thiol isomerase activity in activation of alphaIIb beta3 and highlight the novel regulation of platelet function by other, as yet undefined thiol isomerases...
  94. ncbi Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling
    Shinya Goto
    Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan
    J Am Coll Cardiol 47:155-62. 2006
    ..We sought to evaluate the mechanisms that support the stability of platelet aggregates on a thrombogenic surface exposed to flowing blood...
  95. pmc Platelet granule secretion continuously prevents intratumor hemorrhage
    Benoit Ho-Tin-Noe
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:6851-8. 2008
    ..The study also suggests platelet function as a reasonable target for specific destabilization of tumor vessels...
  96. doi Hemocompatibility of poly(ether imide) membranes functionalized with carboxylic groups
    R Tzoneva
    Institute of Biophysics, Bulgarian Academy of Sciences, Acad G Bonchev St, Bl 108, Sofia 1113, Bulgaria
    J Mater Sci Mater Med 19:3203-10. 2008
    ..However, overall the hemocompatibility of all PEI membranes was higher than that of PET...
  97. ncbi Plasma-deposited tetraglyme surfaces greatly reduce total blood protein adsorption, contact activation, platelet adhesion, platelet procoagulant activity, and in vitro thrombus deposition
    Lan Cao
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    J Biomed Mater Res A 81:827-37. 2007
    ..The improved blood compatibility of plasma-deposited tetraglyme is thus not only due to their reduced platelet adhesion and activation, but also to a generalized reduction in blood interactions...
  98. ncbi Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide
    T David
    INSERM U311, Strasbourg EFS Alsace, Strasbourg, France
    J Thromb Haemost 4:2645-55. 2006
    ..This interaction also plays an important role in initiating platelet activation through the generation of intracellular signals resulting in platelet shape change and integrin alpha(IIb)beta3 activation...
  99. ncbi Platelet secretion: indiscriminately spewed forth or highly orchestrated?
    G C White
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53201 2178, USA
    J Thromb Haemost 5:2006-8. 2007
  100. ncbi Platelet function under high-shear conditions from platelet concentrates
    Petra Jilma-Stohlawetz
    Department of Blood Group Serology and Transfusion Medicine and Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Transfusion 48:129-35. 2008
    ..Platelet (PLT) collection and storage affect the functional capacity of PLTs in PLT concentrates (PCs). Therefore, PLTs' functional quality should be studied before transfusion...
  101. ncbi Preconditioning ischemia attenuates molecular indices of platelet activation-aggregation
    M D Linden
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Haemost 4:2670-7. 2006
    ..However, there is, at present, no direct evidence that PC acts on the platelets per se and favorably down-regulates platelet reactivity...

Research Grants123 found, 100 shown here

  1. Role of von Willebrand Factor in Platelet Thrombus Formation
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..Understanding these different functions requires addressing structural details as well as verification of concepts in intravidal models. This will lead to a better diagnosis and treatment for cardio- and cerebro-vascular diseases. ..
  2. Mechanisms of Thrombus Instability
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..These studies will provide novel insights into the unexpected role of leptin in platelet function, and in the formation and stability of thrombi. ..
  3. Thrombus Formation and Antithrombotic Intervention
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  4. Platelet interactions with vessel wall components
    ZAVERIO RUGGERI; Fiscal Year: 2005
    ..These findings will provide a better definition and characterization of several potential targets for antithrombotic intervention that may yield new treatments for patients at risk of cardiovascular and cerebrovascular events. ..
  5. Structure and function of platelet membrane glycoproteins
    ZAVERIO RUGGERI; Fiscal Year: 2007
    ..abstract_text> ..
  6. Initiation and Regulation of Platelet Thrombus Formation
    ZAVERIO RUGGERI; Fiscal Year: 2004
    ..The results of the proposed studies will have an impact on public health by providing novel mechanistic information on processes that are central to normal hemostasis and pathological arterial thrombosis. ..
  7. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2011
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  8. Structure and function of platelet membrane glycoproteins
    Zaverio M Ruggeri; Fiscal Year: 2010
    ..This new knowledge may translate into improved diagnosis and treatment of common and serious diseases, thus enhancing human health. ..
  9. ROLE OF JAM-1 IN CELL ADHESION AND MIGRATION
    Ulhas Naik; Fiscal Year: 2003
    ..Characterizing the cell adhesion function of this novel protein will open up a new line of investigation that is important in inflammatory diseases and vascular biology. ..
  10. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  11. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
  12. Role of JAM Family in Angiogenesis
    Ulhas Naik; Fiscal Year: 2007
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a new line of investigation that is important in tumorigenesis and vascular biology. ..
  13. INTERACTION OF OSTEOPONTIN WITH ADHESION RECEPTORS
    JOEL BENNETT; Fiscal Year: 2002
    ..Our results suggest that it may be possible to inhibit the formation of platelet thrombi in arteries involved by atherosclerosis by preventing the interaction of platelet alphavbeta3 with osteopontin. ..
  14. REGULATION OF PLATELET AND ENDOTHELIAL CELL FUNCTION
    JOEL BENNETT; Fiscal Year: 2007
    ..The five projects are supported by core facilities for the production of monoclonal antibodies and for the overall administration of the Program. ..
  15. MEDICAL SCIENTIST TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
    ....
  16. Regulation of the early events of platelet activation
    Lawrence F Brass; Fiscal Year: 2010
    ..A better understanding of this critical, but under-explored aspect of platelet biology is key to understanding and preventing what goes wrong when people have heart and strokes. ..
  17. CHARACTERIZATION OF A NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 1993
    ....
  18. HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAM
    Lawrence Brass; Fiscal Year: 2007
    ..abstract_text> ..
  19. CHARACTERIZATION OF A NOVEL G PROTEIN IN PLATELETS
    Lawrence Brass; Fiscal Year: 2005
    ..All four of these aims will combine biochemical and pharmacologic approaches with studies on genetically engineered mice lacking selected receptors and G proteins, allowing us to better understand platelet activation in vivo. ..
  20. NOVEL G PROTEIN IN HUMAN PLATELETS
    Lawrence Brass; Fiscal Year: 2000
    ..It is suggested that these aims will help to define the role of Gz in platelet activation and understand factors responsible for megakaryocyte-selective gene regulation. ..
  21. FASEB Conf. Proteases in Hemostasis and Vascular Biology
    Lawrence Brass; Fiscal Year: 2005
    ..Tissue factor, platelets and coagulation; 8. Regulators of hemostasis; 9. Protease receptors. The keynote lecture will be on gene therapy for disorders of hemostasis delivered by Dr. Katherine High. ..
  22. Proteomic studies of normal and abnormal platelet function
    Lawrence Brass; Fiscal Year: 2007
    ..This includes novel methods that permit quantitation of individual molecules so that changes in levels of expression can be measured. ..
  23. Characterization of coagulation factor-platelet interactions: role of FXI
    Owen J McCarty; Fiscal Year: 2010
    ..We propose that elucidation of the role that FXI plays in clot formation may provide the basis for the pharmaceutical development of such a novel class of FXI-targeted anti-thrombotics. ..
  24. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2007
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease. Thus, giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  25. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2009
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..
  26. Ultra-Large von Willebrand Factor and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2010
    ..Results will help us to dissect this novel mechanism of shear-induced VWF activation. New information will be critical for development new strategies to regulate the role of VWF in hemostasis and thrombosis. ..
  27. Proteolysis of ultralarge von Willebrand factor and metabolic syndrome-diabetes
    Jing Fei Dong; Fiscal Year: 2010
    ..Results of the study will help us to understand how defective ULVWF proteolysis contributes to the development of atherothrombosis associated with the syndrome. ..
  28. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2003
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  29. Ultra-Large VWF and Thrombotic Microangiopathy
    Jing Fei Dong; Fiscal Year: 2006
    ..Finally, they allow us to develop a clinical assay to test the activity of the VWF-cleaving protease thus giving the ability to diagnose TTP. This assay will be fast and more physiologically relevant. ..
  30. YOUTH TAKE HEART (PHASE I & II)
    Buddy Ratner; Fiscal Year: 2007
    ..Youth Take Heart will help enhance the cardiovascular health and quality of life for numerous students through the teaching of medical management, prevention, and control of risk factors for heart disease. ..
  31. Regulation of vascular development and function by LKLF
    Mark L Kahn; Fiscal Year: 2010
    ..Understanding the mechanism by which LKLF regulates genetic responses in the developing and mature vasculature is expected to provide new insights into the pathogenesis and treatment of human vascular diseases. ..
  32. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  33. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy Ratner; Fiscal Year: 2009
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  34. CELLULAR MODULATION OF MICROVESSEL PERMEABILITY IN VIVO
    Pingnian He; Fiscal Year: 2009
    ..A better understanding of the mechanisms that regulate microvessel permeability is crucial to defining the pathogenesis of many disease conditions, and to aid in the development of novel therapeutic approaches. ..
  35. Reaction and Transport Dynamics in Human Blood
    Scott Diamond; Fiscal Year: 2009
    ..Overall, these studies seek to provide fundamental insight into cell-cell interacitions and coagulation biochemistry that occur under flow. ..
  36. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Candace Johnson; Fiscal Year: 2009
    ..We also propose to examine molecular changes in tumor tissue after therapy which could significantly impact the design of the proposed therapeutic approach. ..
  37. Novel Molecules in Calcium Signaling in Platelets
    Wolfgang Bergmeier; Fiscal Year: 2010
    ..Our work will be of great value for a better understanding of these processes in platelets and other cells, such as leukocytes or neurons, and it may lead to the identification of novel targets for antiplatelet therapy. ..
  38. Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds
    Buddy D Ratner; Fiscal Year: 2010
    ..This comprehensive approach to heart muscle repair will be implemented by a collaborative, multidisciplinary team closely integrating engineers, scientists and clinicians. ..
  39. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Donald L Trump; Fiscal Year: 2010
    ..We also propose to examine molecular changes in tumor tissue after therapy which could significantly impact the design of the proposed therapeutic approach. ..
  40. 1st International Symposium on Wound Healing and Technology (WHAT I)
    Buddy Ratner; Fiscal Year: 2006
    ..Communication and discussion of these problems and new ideas for how we can address them are central to this meeting. ..
  41. Platelet Liposomal Drug Delivery--Thrombosis /Restenosis
    Shuwu Wang; Fiscal Year: 2006
    ..The targeted liposomal system proposed could reduce the costs in both treatment areas with a 5% reduction in revascularizations alone leading to >$60 million annual medical cost savings. ..
  42. MECHANISMS OF NONVIRAL CARDIOVASCULAR GENE TRANSFER
    Scott Diamond; Fiscal Year: 2004
    ..Overall, these studies will investigate the delivery of plasmids to the nucleus of nondividing endothelium or smooth muscle cells in order to improve nonviral gene transfer. ..
  43. Mechanisms of Cardiopulmonary Gene Transfer
    Scott Diamond; Fiscal Year: 2007
    ..Overall, these bioengineering studies will focus on barriers/rate limits that prevent high efficiency gene transfer. ..
  44. REACTION AND TRANSPORT DYNAMICS DURING THROMBOLYSIS
    Scott Diamond; Fiscal Year: 1999
    ..Overall, the understanding of spatial dynamics in dissolving thrombi will help facilitate the rational design and optimization of lytic therapy, particularly those approaches involving catheters or combined therapeutic agents. ..