Genomes and Genes
Summary: Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Publications394 found, 100 shown here
- Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the ratR A Swain
Department of Psychology, University of Illinois, 61801, Urbana, IL, USA
Neuroscience 117:1037-46. 2003..flow-alternating inversion recovery (FAIR) functional magnetic resonance imaging to assess chronic changes in blood volume and flow as a result of exercise...
- Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume mapsKyrre E Emblem
Departments of Medical Physics, Rikshospitalet Radiumhospitalet Medical Centre, Sognsvannsveien 20, N 0027 Oslo, Norway
Radiology 247:808-17. 2008..of an alternative method used to grade gliomas that is based on histogram analysis of normalized cerebral blood volume (CBV) values from the entire tumor volume (obtained with the histogram method) with that of the hot-spot method,..
- Blood volume and hemoglobin mass in endurance athletes from moderate altitudeWalter Schmidt
Dept of Sports Medicine and Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
Med Sci Sports Exerc 34:1934-40. 2002To determine whether total hemoglobin (tHb) mass and total blood volume (BV) are influenced by training, by chronic altitude exposure, and possibly by the combination of both conditions.
- Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance studyA M Blamire
Medical Research Council Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
J Neurosci 20:8153-9. 2000..Four hours after injection of IL-1beta (1 ng in 1 microliter), cerebral blood volume was significantly increased, the blood-brain barrier (BBB) became permeable to intravenously administered ..
- Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do notJ L Boxerman
Department of Radiology, Rhode Island Hospital and Brown University Medical School, Providence, RI 02903, USA
AJNR Am J Neuroradiol 27:859-67. 2006Relative cerebral blood volume (rCBV) estimates for high-grade gliomas computed with dynamic susceptibility contrast MR imaging are artificially lowered by contrast extravasation through a disrupted blood-brain barrier...
- Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imagingMeng Law
Department of Radiology, New York University Medical Center, NY, USA
AJNR Am J Neuroradiol 24:1989-98. 2003..Relative cerebral blood volume (rCBV) measurements derived from perfusion MR imaging and metabolite ratios from proton MR spectroscopy are ..
- Apparent diffusion coefficient and cerebral blood volume in brain gliomas: relation to tumor cell density and tumor microvessel density based on stereotactic biopsiesN Sadeghi
Department of Radiology, Hopital Erasme, Brussels, Belgium
AJNR Am J Neuroradiol 29:476-82. 2008MR imaging-based apparent diffusion coefficient (ADC) and regional cerebral blood volume (rCBV) measurements have been related respectively to both cell and microvessel density in brain tumors...
- Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomasM Law
Department of Radiology, NYU Medical Center, New York, NY, USA
AJNR Am J Neuroradiol 28:761-6. 2007..datasets and can be as effective as traditional region-of-interest (ROI) measurements of relative cerebral blood volume (rCBV), an operator-dependent method...
- Low-grade gliomas: dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging--prediction of patient clinical responseMeng Law
Department of Radiology, New York University Medical Center, MRI Department, Schwartz Building, Basement HCC, 530 First Ave, New York, NY 10016, USA
Radiology 238:658-67. 2006To determine retrospectively whether relative cerebral blood volume (CBV) measurements can be used to predict clinical response in patients with low-grade gliomas.
- Whole-body vibration exercise leads to alterations in muscle blood volumeK Kerschan-Schindl
Department of Physical Medicine and Rehabilitation, University of Vienna, Vienna, Austria
Clin Physiol 21:377-82. 2001..The aim of this investigation was to quantify alterations in muscle blood volume after whole muscle vibration--after exercising on the training device Galileo 2000 (Novotec GmbH, Pforzheim, ..
- Perfusion and diffusion MR imaging in enhancing malignant cerebral tumorsCem Calli
Department of Radiology, Ege University Medical School, 35100 Bornova, Izmir, Turkey
Eur J Radiol 58:394-403. 2006..Our aim was to evaluate the role of perfusion MR imaging (PWI) and diffusion-weighted imaging (DWI) in the differentiation of these contrast-enhancing malignant cerebral tumors...
- Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humansKaike K Kaisti
Department of Anesthesiology, Turku University Hospital, Finland
Anesthesiology 99:603-13. 2003..of sevoflurane and propofol as sole anesthetics and in combination with N2O on regional cerebral blood flow (rCBF), metabolic rate of oxygen (rCMRO2), and blood volume (rCBV) in the living human brain using positron emission tomography.
- Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat modelsGiselle Fabiana Prunell
Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institute, Stockholm, Sweden
Neurosurgery 52:165-75; discussion 175-6. 2003..To investigate which of three subarachnoid hemorrhage (SAH) models is the most suitable for studies of pathological and pathophysiological processes after SAH...
- Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 teslaHenrik B W Larsson
Functional Imaging Unit, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
Magn Reson Med 62:1270-81. 2009..In this study, a procedure is presented that allows concurrent estimation of cerebral perfusion, blood volume, and blood-brain permeability from dynamic T(1)-weighted imaging of a bolus of a paramagnetic contrast agent ..
- Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteersDileep N Lobo
Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
Crit Care Med 38:464-70. 2010To study the changes in blood volume and hormones controlling sodium and water homeostasis after infusions of 0.9% saline, Gelofusine (4% succinylated gelatin in 0...
- Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imagingSoonmee Cha
Department of Radiology, University of California San Francisco, UCSF Medical Center, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 26:266-73. 2005..We hypothesized that tumor blood-volume measurements, derived from DSC MR imaging, would help differentiate the two on the basis of differences in tumor vascularity...
- Flat detector CT in the evaluation of brain parenchyma, intracranial vasculature, and cerebral blood volume: a pilot study in patients with acute symptoms of cerebral ischemiaT Struffert
Department of Neuroradiology, University of Erlangen Nuremberg, Erlangen, Germany
AJNR Am J Neuroradiol 31:1462-9. 2010..We tested the hypothesis that when used in conjunction with IV contrast, FD-CT imaging would provide both anatomic and physiologic information that would correlate well with that obtained by using standard multisection CT techniques...
- Gliomas: application of cumulative histogram analysis of normalized cerebral blood volume on 3 T MRI to tumor gradingHyungjin Kim
Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
PLoS ONE 8:e63462. 2013..The objective of our study was to retrospectively assess the usefulness of a cumulative normalized cerebral blood volume (nCBV) histogram for glioma grading based on 3 T MRI.
- Perfusion MRI (dynamic susceptibility contrast imaging) with different measurement approaches for the evaluation of blood flow and blood volume in human gliomasH Thomsen
Den Sundhedsfaglige Kandidatuddannelse, Aarhus Universitet Bygning, Arhus, Denmark
Acta Radiol 53:95-101. 2012..Relative cerebral blood volume (rCBV) is usually obtained by dynamic susceptibility contrast (DSC) MRI using normal appearing white matter as ..
- Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingMeng Law
Department of Radiology, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
Radiology 247:490-8. 2008To retrospectively determine whether relative cerebral blood volume (CBV) measurements can be used to predict clinical outcome in patients with high-grade gliomas (HGGs) and low-grade gliomas (LGGs) and specifically whether patients who ..
- Modelling vascular reactivity to investigate the basis of the relationship between cerebral blood volume and flow under CO2 manipulationStefan K Piechnik
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Neuroimage 39:107-18. 2008..25 to 0.55 under conditions typical for imaging methods. We conclude that the v-f relationship is not a fixed function but that both the shape and slope depend on the composition of the reactive volume and the experimental methods used...
- Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failureAudrey Borghi-Silva
Pulmonary Function and Clinical Exercise Physiology Unit, Division of Respiratory Diseases, Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
Am J Physiol Heart Circ Physiol 294:H2465-72. 2008..in deoxy-hemoglobyn, oxi-Hb ([O2Hb]), tissue oxygenation index, and total Hb ([HbTOT], an index of local blood volume) in the vastus lateralis were measured by near infrared spectroscopy...
- Rapid quantitative measurement of CMRO(2) and CBF by dual administration of (15)O-labeled oxygen and water during a single PET scan-a validation study and error analysis in anesthetized monkeysNobuyuki Kudomi
Department of Investigative Radiology, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan
J Cereb Blood Flow Metab 25:1209-24. 2005..Error sensitivity to cerebral blood volume (CBV) was also identical to that in the three-step and reasonably small, suggesting that a single CBV ..
- Histogram analysis of MR imaging-derived cerebral blood volume maps: combined glioma grading and identification of low-grade oligodendroglial subtypesK E Emblem
Department of Medical Physics, Rikshospitalet University Hospital, Oslo, Norway
AJNR Am J Neuroradiol 29:1664-70. 2008....
- Blood contrast agents enhance intrinsic signals in the retina: evidence for an underlying blood volume componentJesse Schallek
Department of Neurosurgery, Upstate Medical University, Syracuse, New York, USA
Invest Ophthalmol Vis Sci 52:1325-35. 2011..To examine the extent to which neurovascular coupling contributes to stimulus-evoked intrinsic signals in the retina...
- Basal cerebral blood volume during the poststimulation undershoot in BOLD MRI of the human brainPeter Dechent
MR Research in Neurology and Psychiatry, Georg August Universitat, Gottingen, Germany
J Cereb Blood Flow Metab 31:82-9. 2011..poststimulation undershoot, which has been suggested to originate from a delayed recovery of either cerebral blood volume (CBV) or cerebral metabolic rate of oxygen to baseline...
- Reduction of hypotensive side effects during online-haemodiafiltration and low temperature haemodialysisJohannes Donauer
Department of Nephrology, University Hospital Freiburg, Germany
Nephrol Dial Transplant 18:1616-22. 2003..This study compares the effect of online-haemodiafiltration (o-HDF, post-dilution mode) with conventional haemodialysis (HD) and 'temperature-controlled' HD (Temp-HD) on the haemodynamic stability of hypotension-prone patients...
- Cardiac origins of the postural orthostatic tachycardia syndromeQi Fu
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas 75231, USA
J Am Coll Cardiol 55:2858-68. 2010The purpose of this study was to test the hypothesis that a small heart coupled with reduced blood volume contributes to the postural orthostatic tachycardia syndrome (POTS) and that exercise training improves this syndrome.
- Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume mapsMichael A Badruddoja
Department of Neurology and Neurosurgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neuro Oncol 5:235-43. 2003..We demonstrate, by constructing relative cerebral blood volume (rCBV) maps with MRI, that dexamethasone also decreases total blood volume while increasing microvascular blood ..
- Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma gradeMeng Law
Department of Radiology, NYU Medical Center, NY 10016, USA
AJNR Am J Neuroradiol 25:746-55. 2004Relative cerebral blood volume (rCBV) and vascular permeability (K(trans)) permit in vivo assessment of glioma microvasculature...
- Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric strokeMax Wintermark
Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
Stroke 37:979-85. 2006....
- Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressureChung Chi Huang
Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
Crit Care Med 36:2810-6. 2008....
- Assessment of intrathoracic blood volume as an indicator of cardiac preload: single transpulmonary thermodilution technique versus assessment of pressure preload parameters derived from a pulmonary artery catheterC Wiesenack
Department of Anaesthesia, University Hospital, Regensburg, Germany
J Cardiothorac Vasc Anesth 15:584-8. 2001..with changes in cardiac output or stroke volume, whereas changes in volume preload parameter intrathoracic blood volume (ITBV) of the PiCCO correlated significantly with changes in cardiac output and stroke volume (r = 0...
- Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomyM Rehm
, , Klinikum Grosshadern, Munich, Germany
Anesthesiology 95:849-56. 2001BACKGROUND: The impact of acute preoperative volume loading with colloids on blood volume has not been investigated sufficiently...
- Quantitative assessment of the ischemic brain by means of perfusion-related parameters derived from perfusion CTM Koenig
Departments of Radiology and Nuclear Medicine, Ruhr University Bochum, Germany
Stroke 32:431-7. 2001..objective was to determine whether measurements of the relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative time to peak (rTP) can be used to differentiate areas undergoing infarction from ..
- Changes in cerebral blood volume and cerebral oxygenation during periodic breathing in term infantsB Urlesberger
Department of Paediatrics, University of Graz, Austria
Neuropediatrics 31:75-81. 2000The present study is an analysis of changes in cerebral oxygenation and cerebral blood volume (CBV) during periodic breathing in healthy term infants by means of near infrared spectroscopy (NIRS)...
- Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determinationXin Li
W M Keck Foundation High Field MRI Laboratory Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR 97239, United States
J Magn Reson 206:190-9. 2010The accurate mapping of the tumor blood volume (TBV) fraction (vb) is a highly desired imaging biometric goal...
- Pulmonary blood volume variation decreases after myocardial infarction in pigs: a quantitative and noninvasive MR imaging measure of heart failureMartin Ugander
Cardiac MR Group, Department of Radiology and Physiology, Skane University Hospital, Lund University, Getingevagen, SE 22185 Lund, Sweden
Radiology 256:415-23. 2010To prospectively evaluate the usefulness of magnetic resonance (MR) imaging for estimating pulmonary blood volume (PBV) and the variation in PBV throughout the cardiac cycle in experimental heart failure.
- Contrast echocardiography for pulmonary blood volume quantificationMassimo Mischi
Eindhoven University of Technology, Eindhoven, The Netherlands
IEEE Trans Ultrason Ferroelectr Freq Control 51:1137-47. 2004Pulmonary blood volume quantification is important both for diagnosis and for monitoring of the circulatory system...
- Comparison of cerebral blood volume maps generated from T2* and T1 weighted MRI data in intra-axial cerebral tumoursH A Haroon
Division of Imaging Science and Biomedical Engineering, Faculty of Medical and Human Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Br J Radiol 80:161-8. 2007We compared parametric maps, measured values and value distributions of cerebral blood volume (CBV) derived from (1) first pass T1 weighted dynamic contrast-enhanced (DCE) data (T1-CBV) using the recently described leakage profile model ..
- Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma?S J Mills
Department of Imaging Science and Biomedical Engineering, Christie Hospital NHS Trust, Manchester, United Kingdom
AJNR Am J Neuroradiol 27:853-8. 2006Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (K(trans)) have potential benefits in the diagnosis and therapeutic management of adult glioma...
- Total hemoglobin mass and blood volume of elite Kenyan runnersNicole Prommer
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Bayreuth, Germany
Med Sci Sports Exerc 42:791-7. 2010..Several East Africans are among the most successful runners worldwide. The physiological reasons underlying this superiority are, however, not yet known...
- Blood volume perturbations in the postural tachycardia syndromeSatish R Raj
Autonomic Dysfunction Center, Division of Clinical Pharmacology, Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
Am J Med Sci 334:57-60. 2007..POTS can be associated with a high degree of functional disability. The blood volume has been found to be low in many patients with POTS...
- MR cerebral blood volume maps correlated with vascular endothelial growth factor expression and tumor grade in nonenhancing gliomasAntonio C M Maia
Centro de Medicina Diagnóstica Fleury and the Department of Neurology, Universidade Federal de Sao Paulo, Brazil
AJNR Am J Neuroradiol 26:777-83. 2005Relative cerebral blood volume (rCBV) measurements derived from perfusion-weighted imaging (PWI) may be useful to evaluate angiogenesis and preoperatively estimate the grade of a glioma...
- Evaluation of markers to estimate volume status in hemodialysis patients: atrial natriuretic peptide, inferior vena cava diameter, blood volume changes and filtration coefficients of microvasculatureMasatomo Yashiro
Division of Nephrology, Kyoto City Hospital, Kyoto, Japan
Ther Apher Dial 11:131-7. 2007..ratio (CTR), atrial natriuretic peptide (ANP), inferior vena cava diameter at quiet expiration (IVCe), blood volume change (Delta BV/TUF) during ultrafiltration and filtration coefficients of microvasculature (Lpst) - were ..
- Dual gradient-echo MRI of post-contraction changes in skeletal muscle blood volume and oxygenationBruce M Damon
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA
Magn Reson Med 57:670-9. 2007..We conclude that following brief human skeletal muscle contractions, changes in S(6) primarily reflect changes in blood volume and changes in S(46) primarily reflect changes in blood oxygenation.
- Role of the acid-sensing ion channel 3 in blood volume controlCheng Han Lee
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
Circ J 75:874-83. 2011The mechanically sensitive volume receptors, primarily located in the venoatrial junction area, are essential for blood volume homeostasis. However, the molecular basis of the volume receptors is still unknown.
- Modeling and optimization of Look-Locker spin labeling for measuring perfusion and transit time changes in activation studies taking into account arterial blood volumeS T Francis
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, UK
Magn Reson Med 59:316-25. 2008..It was found that perfusion increased by 83 +/- 4% on brain activation from a resting state value of 94 +/- 13 ml/100 g/min, while T*(2) increased by 3.5 +/- 0.5%...
- Effects of various training modalities on blood volumeW Schmidt
Department of Sports Medicine Sports Physiology, University of Bayreuth, Bayreuth, Germany
Scand J Med Sci Sports 18:57-69. 2008..This increase is, however, not sufficient to close the gap in tHb-mass to elite athletes native to altitude, which may be in advantage when tHb-mass has the same strong influence on aerobic performance at altitude as it has on sea level...
- Which CT perfusion parameter best reflects cerebrovascular reserve?: correlation of acetazolamide-challenged CT perfusion with single-photon emission CT in Moyamoya patientsN J Rim
Department of Diagnostic Radiology, Ajou University School of Medicine, Gyeonggi Do, Korea
AJNR Am J Neuroradiol 29:1658-63. 2008..We assessed whether there is any resting or drug-challenged CTP parameter correlating with cerebrovascular reserve (CVR) obtained by SPECT in Moyamoya patients...
- Vastus lateralis oxygenation and blood volume measured by near-infrared spectroscopy during whole body vibrationEiji Yamada
Department of Rehabilitation, Faculty of Medicine, Kagawa University Hospital, Kagawa, Japan
Clin Physiol Funct Imaging 25:203-8. 2005..Therefore, WBV exercise may be an efficient training stimulus for muscle deoxygenation...
- Acute l-arginine supplementation increases muscle blood volume but not strength performanceThiago Silveira Alvares
Gama Filho University, Rio de Janeiro, Brazil
Appl Physiol Nutr Metab 37:115-26. 2012..on biceps strength performance, indicators of NO production (nitrite and nitrate - NOx), and muscle blood volume (Mbv) and oxygenation (Mox) during recovery from 3 sets of resistance exercise...
- Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagingsI Chan Chiang
Department of Radiology, Chung Ho Memorial Hospital, Kaohsiung Medical University, No 100 Shih chuan 1st Road, Kaohsiung, Taiwan
Neuroradiology 46:619-27. 2004This study compared the effectiveness of relative cerebral blood volume, apparent diffusion coefficient, and spectroscopic imaging in differentiating between primary high-grade gliomas and solitary metastases. A 3...
- Serial measurement of extravascular lung water and blood volume during the course of neurogenic pulmonary edema after subarachnoid hemorrhage: initial experience with 3 casesTatsushi Mutoh
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
J Neurosurg Anesthesiol 24:203-8. 2012..This is the first report to demonstrate the ability of a bedside transpulmonary thermodilution device to trace physiological patterns consistent with current theories regarding the mechanism and course of post-SAH NPE...
- Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndromeSatish R Raj
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tenn 37232 2195, USA
Circulation 111:1574-82. 2005..We prospectively tested the hypothesis that patients with POTS are hypovolemic compared with healthy controls and explored the role of plasma renin activity and aldosterone in the regulation of plasma volume...
- Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingRamon F Barajas
Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
Radiology 253:486-96. 2009To investigate whether cerebral blood volume (CBV), peak height (PH), and percentage of signal intensity recovery (PSR) measurements derived from the results of T2-weighted dynamic susceptibility-weighted contrast material-enhanced (DSC) ..
- Applicability of tableside flat panel detector CT parenchymal cerebral blood volume measurement in neurovascular interventions: preliminary clinical experienceP Mordasini
Department of Interventional and Diagnostic Neuroradiology, Inselspital, University of Bern, Switzerland
AJNR Am J Neuroradiol 33:154-8. 2012..The aim of this work was to analyze our preliminary clinical experience with this new imaging tool in different neurovascular interventions...
- Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRIGlyn Johnson
Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
Magn Reson Med 51:961-8. 2004..Intravascular indicator dilution theory has been used to estimate blood volume (and perfusion), usually from T(2)- or T(2) (*)-weighted images of the first pass of the bolus...
- Relationship between erector spinae static endurance and muscle oxygenation-blood volume changes in healthy and low back pain subjectsRobert T Kell
Faculty of Kinesiology and Health Studies, University of Regina, SK, Canada
Eur J Appl Physiol 96:241-8. 2006The purposes of this study were to: (1) compare the muscle blood volume (Mbv) and oxygenation (Mox) responses on the right and left side erector spinae during the Biering-Sorensen muscle endurance (BSME) test between healthy, low back ..
- Evaluation of different cerebral mass lesions by perfusion-weighted MR imagingBahattin Hakyemez
Department of Radiology, Uludag University Medical School, and Bursa State Hospital, Bursa, Turkey
J Magn Reson Imaging 24:817-24. 2006To investigate the contribution of perfusion-weighted MR imaging (PWI) by using the relative cerebral blood volume (rCBV) ratio in the differential diagnosis of various intracranial space-occupying lesions.
- Serotonergic mechanisms of the lateral parabrachial nucleus in renal and hormonal responses to isotonic blood volume expansionLisandra Oliveira Margatho
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto Sao Paulo, Brazil
Am J Physiol Regul Integr Comp Physiol 292:R1190-7. 2007..excretion, potassium (K+) excretion, and urinary volume in unanesthetized rats subjected to acute isotonic blood volume expansion (0.15 M NaCl, 2 ml/100 g of body wt over 1 min) or control rats...
- On the physical and stochastic representation of an indicator dilution curve as a gamma variateM Mischi
Department of Electrical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands
Physiol Meas 29:281-94. 2008..Dilution curves were measured by contrast ultrasonography both in vitro and in vivo (20 patients). Blood volume measurements were used to test the accuracy and clinical relevance of the estimated parameters...
- A reference frame for blood volume in children and adolescentsAnn Raes
Department of Paediatric Nephrology, University Hospital, Ghent, Belgium
BMC Pediatr 6:3. 2006Our primary purpose was to determine the normal range and variability of blood volume (BV) in healthy children, in order to provide reference values during childhood and adolescence...
- The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patientsCyril Charron
Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
Anesth Analg 102:1511-7. 2006..In conclusion, Delta%VTI(Ao) and Delta%Pp are good predictors of intravascular fluid responsiveness but the divergent evolution of these two variables when Vt was increased needs further explanation...
- Quantification of cerebral blood flow, cerebral blood volume, and blood-brain-barrier leakage with DCE-MRISteven Sourbron
Institute of Clinical Radiology, Ludwig Maximilian University Munich, Munich, Germany
Magn Reson Med 62:205-17. 2009..contrast MRI (DSC-MRI) is the current standard for the measurement of Cerebral Blood Flow (CBF) and Cerebral Blood Volume (CBV), but it is not suitable for the measurement of Extraction Flow (EF) and may not allow for absolute ..
- Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain gliomaN Sadeghi
Department of Radiology, Hopital Erasme, Brussels, Belgium
AJNR Am J Neuroradiol 28:455-61. 2007..We used image coregistration and stereotactic biopsies to regionally compare cerebral blood volume (CBV) and (11)C-methionine (MET) uptake measurements in brain gliomas and to assess their relationship by ..
- Predicting BOLD signal changes as a function of blood volume fraction and resolutionY C Cheng
Department of Physics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7079, USA
NMR Biomed 14:468-77. 2001..To address this issue, we simulate the signal change between activated and resting states as a function of blood volume fraction (lambda)...
- Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusioL S Hu
Department of Radiology, Mayo Clinic, Phoenix Scottsdale, AZ 85259, USA
AJNR Am J Neuroradiol 30:552-8. 2009..To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist...
- Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trialDonal N Reddan
Duke University Medical Center, Box 3646, Durham, NC 27710, USA
J Am Soc Nephrol 16:2162-9. 2005..This trial tested the hypothesis that availability of an intradialytic blood volume monitoring (IBVM) device improves fluid removal, reducing morbidity...
- Assessment of placental fractional moving blood volume using quantitative three-dimensional power doppler ultrasoundChen Hsiang Yu
Department of Obstetrics and Gynecology, National Chen Kung University Medical College and Hospital, Tainan, Taiwan
Ultrasound Med Biol 29:19-23. 2003To test the hypothesis that the placental fractional moving blood volume is different with advancing gestational age (GA), we assessed the vascularization index (VI), flow index (FI), and vascularization-flow index (VFI) of the placenta ..
- [Assessment of stroke volume variation and intrathoracic blood volume index on the responsiveness to volume loading in mechanically ventilated canine with hemorrhagic shock]Song Qiao Liu
Department of Critical Care Medicine, Zhong Da Hospital and School of Clinical Medicine, Southeast University, Nanjing 210009, China
Zhonghua Wai Ke Za Zhi 44:1216-9. 2006To assess the significance of stroke volume variation (SVV) and intrathoracic blood volume index (ITBI) on the responsiveness to volume loading in mechanically ventilated canine with hemorrhagic shock.
- Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126Simon P Robinson
Department of Basic Medical Sciences, St George s, University of London, London, United Kingdom
Int J Radiat Oncol Biol Phys 69:872-9. 2007To assess tumor fractional blood volume (xi), determined in vivo by susceptibility contrast magnetic resonance imaging (MRI) as a noninvasive imaging biomarker of tumor response to the vascular disrupting agent ZD6126.
- Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fractionEmerson L Gasparetto
Division of Neuroradiology, Department of Radiology, Division of Neuro Oncology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiology 250:887-96. 2009To determine the accuracy of relative cerebral blood volume (rCBV) fraction for distinguishing high-grade recurrent neoplasm from treatment-related necrosis (TRN) in enhancing masses identified on surveillance magnetic resonance (MR) ..
- Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic strokeBruce C V Campbell
Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville VIC 3050, Australia
Stroke 41:82-8. 2010..Preliminary studies have suggested that very low cerebral blood volume (VLCBV) predicts HT. We compared HT prediction by VLCBV and DWI using data from the EPITHET study.
- Enrichment of circulating tumor cells from a large blood volume using leukapheresis and elutriation: proof of conceptRobert L Eifler
Department of Clinical Medicine and Biotechnology, Danube University, Krems, Austria Department of Blood Transfusion, Medical University of Vienna, Austria
Cytometry B Clin Cytom 80:100-11. 2011..the applicability of a sequential process using leukapheresis, elutriation, and fluorescence-activated cell sorting (FACS) to enrich and isolate circulating tumor cells from a large blood volume to allow further molecular analysis.
- Exercise-induced pulmonary edema in heart failurePiergiuseppe Agostoni
Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
Circulation 108:2666-71. 2003..If pulmonary edema developed, alveolar-capillary membrane conductance (Dm), measured immediately after exercise, would decrease. To test this hypothesis, we measured Dm before and at 2 and 60 minutes after exercise...
- A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signalValerie E M Griffeth
Department of Bioengineering, University of California, San Diego, CA 92093, USA
Neuroimage 58:198-212. 2011..However, other factors such as the cerebral blood volume (CBV) distribution at rest and with activation also affect the BOLD signal...
- The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteersChristian Kolbitsch
Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, Innsbruck, Austria
Magn Reson Imaging 20:535-41. 2002..0) on regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) in awake, normoventilating volunteers (n = 19)...
- Changes in regional blood volume and blood flow during static handgripJulian M Stewart
Professor of Pediatrics and Physiology, Research Division and Hypotension Laboratory, New York Medical College, Suite 3050, 19 Bradhurst Ave, Hawthorne, NY 10532, USA
Am J Physiol Heart Circ Physiol 292:H215-23. 2007..When evoked by static handgrip, mechanoreceptors and metaboreceptors produce regional changes in blood volume and blood flow, which are incompletely characterized in humans...
- Mapping cyclic change of regional myocardial blood volume using steady-state susceptibility effect of iron oxide nanoparticlesEd X Wu
Department of Radiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Magn Reson Imaging 19:50-8. 2004To demonstrate an in vivo magnetic resonance imaging (MRI) technique that maps the cyclic change of regional myocardial blood volume (MBV) during the cardiac cycle.
- Focused cardiac ultrasound in the emergent setting: a consensus statement of the American Society of Echocardiography and American College of Emergency PhysiciansArthur J Labovitz
St Louis University School of Medicine, St Louis, Missouri, USA
J Am Soc Echocardiogr 23:1225-30. 2010..In the emergency department, focused cardiac ultrasound has become a fundamental tool to expedite the diagnostic evaluation of the patient at the bedside and to initiate emergent treatment and triage decisions by the emergency physician...
- Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxiaC Julien
Unité Mixte INSERM UJF 594, LRC CEA 30 V, Pavillon B, BP 217, Hopital Albert Michallon, F 38043 Grenoble, France
Br J Cancer 91:374-80. 2004..We have determined changes in regional blood volume (BV) during graded hypoxic hypoxia using susceptibility contrast magnetic resonance imaging in a model of rat ..
- Extravascular lung water to blood volume ratios as measures of permeability in sepsis-induced ALI/ARDSA B Johan Groeneveld
Department Intensive Care, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Intensive Care Med 32:1315-21. 2006....
- Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imagingHanzhang Lu
Center of Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
Magn Reson Med 54:1403-11. 2005Quantitative determination of cerebral blood volume (CBV) is important for understanding brain physiology and pathophysiology...
- V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivityTaka Aki Koshimizu
Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 103:7807-12. 2006..Notably, mutant mice showed a significant 9% reduction in circulating blood volume. Furthermore, mutant mice had normal plasma AVP levels and a normal AVP secretory response, but had ..
- Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default stateXiang He
Department of Radiology, Washington University, St Louis, Missouri, USA
Magn Reson Med 57:115-26. 2007..a BOLD MR-based method that allows quantitative evaluation of tissue hemodynamic parameters, such as the blood volume, deoxyhemoglobin concentration, and oxygen extraction fraction (OEF)...
- Blood volume controlled hemodialysis in hypotension-prone patients: a randomized, multicenter controlled trialAntonio Santoro
Divisione de Nefrologia e Dialisi Malpighi, Policlinico S Orsola Malpighi, Via P Palagi 9, 40138 Bologna, Italy
Kidney Int 62:1034-45. 2002Recently we have devised and tested a biofeedback system for controlling blood volume (BV) changes during hemodialysis (HD) along an ideal trajectory (blood volume tracking, BVT), continuously modifying the weight loss rate and dialysate ..
- Functional connectivity in blood oxygenation level-dependent and cerebral blood volume-weighted resting state functional magnetic resonance imaging in the rat brainMatthew Magnuson
Georgia Institute of Technology and Emory University, Biomedical Engineering, Atlanta, Georgia, USA
J Magn Reson Imaging 32:584-92. 2010To directly compare functional connectivity and spatiotemporal dynamics acquired with blood oxygenation level-dependent (BOLD) and cerebral blood volume (CBV)-weighted functional magnetic resonance imaging (fMRI) in anesthetized rats.
- Cerebral blood volume changes in patients with eating disorders during word fluency: a preliminary study using multi-channel near infrared spectroscopyT Uehara
Department of Psychiatry and Human Behavior, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
Eat Weight Disord 12:183-90. 2007..This study investigated the characteristics of cerebral oxygenation changes in eating disorders patients (ED) and normal controls during the cognitive tasks, using a highly time-resolved, and non-invasive instrument...
- Comparison of dynamic susceptibility-weighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumorsEric S Paulson
Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Radiology 249:601-13. 2008To investigate whether estimates of relative cerebral blood volume (rCBV) in brain tumors, obtained by using dynamic susceptibility-weighted contrast material-enhanced magnetic resonance (MR) imaging vary with choice of data acquisition ..
- Functional MRI with magnetization transfer effects: determination of BOLD and arterial blood volume changesTae Kim
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15203, USA tak19 pitt edu
Magn Reson Med 60:1518-23. 2008..This intravascular component is dominated by an arterial blood volume change (DeltaCBV(a)) term whenever venous contributions are minimized...
- Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and waterH Okazawa
PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
J Cereb Blood Flow Metab 21:793-803. 2001..The new method also provided images of arterial blood volume (V0), which is a different parameter from cerebral blood volume (CBV) obtained using a C15O technique...
- Haemodynamic, acid-base and blood volume changes during prolonged low pressure pneumoperitoneum in rabbitsR Sumpelmann
Medizinische Hochschule Hannover, Zentrum Anästhesiologie OE 8050, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
Br J Anaesth 96:563-8. 2006..In this study haemodynamic, acid-base and blood volume changes were investigated during pneumoperitoneum in a small animal model.
- Brain responses to ambient temperature fluctuations in fish: reduction of blood volume and initiation of a whole-body stress responseErwin H van den Burg
Department of Animal Physiology, University of Nijmegen, Nijmegen, The Netherlands
J Neurophysiol 93:2849-55. 2005..This could help to maintain proper brain functioning including sensorimotor activity, initiation of the stress response, and the subsequent behavioral responses...
- Changes in relative cerebral blood volume 1 month after radiation-temozolomide therapy can help predict overall survival in patients with glioblastomaRajiv Mangla
Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, PO Box 648, Rochester, NY 14642 8648, USA
Radiology 256:575-84. 2010....
- Blood volume and hemoglobin mass in elite athletes of different disciplinesK Heinicke
Department of Sports Medicine, University of Bayreuth, Germany
Int J Sports Med 22:504-12. 2001..have considerably larger blood volumes than untrained individuals, there is no data available describing the blood volume variability among differently trained athletes...
- Reduced intrathoracic blood volume and left and right ventricular dimensions in patients with severe emphysema: an MRI studyKirsten Jörgensen
Department of Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, S 413 45 Gothenburg, Sweden
Chest 131:1050-7. 2007..lungs of these patients with high intrinsic positive end-expiratory pressure will decrease intrathoracic blood volume (ITBV) and ventricular preload...
- In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imagingJörg U G Streif
Physikalisches Institut, Lehrstuhl für Experimentelle Physik V Biophysik, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
Magn Reson Med 53:584-92. 2005The absolute perfusion and the intracapillary or regional blood volume (RBV) in murine myocardium were assessed in vivo by spin labeling magnetic resonance imaging...
- Stroke volume variations for assessment of cardiac responsiveness to volume loading in mechanically ventilated patients after cardiac surgeryDaniel A Reuter
Department of Anesthesiology, Grosshadern University Hospital, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Intensive Care Med 28:392-8. 2002....
- Cortical layer-dependent dynamic blood oxygenation, cerebral blood flow and cerebral blood volume responses during visual stimulationTao Jin
Department of Radiology, 3025 East Carson Street, University of Pittsburgh, Pittsburgh, PA 15203, USA
Neuroimage 43:1-9. 2008The spatiotemporal characteristics of cerebral blood volume (CBV) and flow (CBF) responses are important for understanding neurovascular coupling mechanisms and blood oxygenation level-dependent (BOLD) signals...
- Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patientsMelanie van der Heijden
Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
J Crit Care 25:16-22. 2010The aim of this study is to evaluate the value of extravascular lung water (EVLW) to intrathoracic blood volume, global end-diastolic volume, or pulmonary blood volume ratios as a reflection of pulmonary permeability in nonseptic ..
- High resolution functional MRI of columnar structuresRavi Menon; Fiscal Year: 2007..proposed here are aimed at understanding the links between neural activity in the brain, the blood flow, blood volume and blood and tissue oxygenation changes that follow, and the fMRI signal...
- Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trialDavid A Benaron; Fiscal Year: 2010..Further, typical NIRS fails to account for shifts in water, fat, blood volume, and stool, any of which can affect oxygenation measurements if not specifically accounted for, making NIRS ..
- Mechanisms of Vasovagal SyncopeJulian M Stewart; Fiscal Year: 2013..stress, lower body negative pressure (LBNP), while measuring cardiac output by inert gas rebreathing, regional blood volume, and regional blood flow using plethysmographic techniques focusing on splanchnic changes, and muscle ..
- Delivery issues in lung cancer CNS metastasesEdward A Neuwelt; Fiscal Year: 2013..that the heterogeneity of the vasculature in individual metastases and peritumoral brain, in terms of both blood volume and vessel permeability, determines and limits the efficacy of chemo-radiotherapy treatments...
- Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye DilutionIstvan Seri; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cardiac output (CO) and measures of cardiac preload (central blood volume, CBV) and systemic vascular resistance (SVR) are critical clinical parameters of circulatory function...
- ANP Receptor: Molecular approach of signaling mechanismsKailash N Pandey; Fiscal Year: 2013..sodium excretion, fluid volume, and vasorelaxation, important factors in the control of blood pressure and blood volume. Interaction of ANP with its receptor guanylyl cyclase-A/natriuretic peptide receptor-A (GC-A/NPRA) produces ..
- Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible SubjectsMark W Frampton; Fiscal Year: 2010..Effects of exposure on pulmonary vascular function will be assessed by measuring changes in pulmonary capillary blood volume and shifts in peripheral blood leukocyte adhesion molecule expression...
- PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTSJUDITH SMITH MERCER; Fiscal Year: 2012..When immediate cord clamping occurs, up to 25% of the fetal-placental blood volume may be left in the placenta acutely increasing vulnerability to hypovolemia...
- Ozone Cardiovascular Effects in Genetically Susceptible PeopleMARK WALTER FRAMPTON; Fiscal Year: 2012..polymorphisms in GSTM1 and Nrf2 will have increased systemic oxidative stress, reduced pulmonary capillary blood volume, and reduced peripheral vascular responsiveness and tissue perfusion in response to ozone exposure, and that ..
- The baroreflex in pregnancy: effects of adrenal and placental steroidsMaureen Keller-Wood; Fiscal Year: 2012..decrease in baroreflex sensitivity in pregnancy by effects within the CNS, as well as by indirect effects on blood volume. We further hypothesize that these effects are modulated by progesterone and estradiol, and that the ..
- Aldosterone and Sodium Regulation in Postural Tachycardia SyndromeSatish R Raj; Fiscal Year: 2013..studies indicate that aldosterone levels are paradoxically diminished, and this likely contributes to the low blood volume. Quite surprisingly in light of the low aldosterone and blood volume, angiotensin II levels were elevated in ..
- Using Vessel Caliber to Assess Cardiac Impairment in COPDCarolyn E Come; Fiscal Year: 2013..in hyperinflated COPD patients is at least in part related to changes in the distribution of intrathoracic blood volume (.e. alterations in ventricular preload and afterload) that can be corrected with deflation...
- Trophic factors and regulation of hippocampal neuroplasticity in the human brainMaura Boldrini; Fiscal Year: 2012..Angiogenesis is necessary for new neurons to differentiate and survive and cerebral blood volume has been proposed as a surrogate in vivo measure of neurogenesis...
- Mechanisms of Renal Vasodilation by RelaxinKirk P Conrad; Fiscal Year: 2010..These changes are important for both initiating and accommodating increased maternal blood volume and flow that, in turn, support fetal growth...
- HPLC-ICP-MS SystemPETER D CARAVAN; Fiscal Year: 2013..g. perfusion, permeability, blood volume measurements;ex vivo elemental analysis of these contrast agents can serve to calibrate and validate these ..
- Ultrasound Assessment of Microvascular Function in Insulin Resistant PrimatesJonathan R Lindner; Fiscal Year: 2011..Under normal circumstances, physiologic hyperinsulinemia increases capillary blood volume which is thought to augment glucose and insulin delivery to skeletal muscle...
- Pathophysiology of Heart Failure with a Normal Ejection Fraction in the ElderlyMathew S Maurer; Fiscal Year: 2010..high (>50%) in elderly patients hospitalized with HFNEF, most of these subjects (76%) have a true anemia by blood volume analysis, which is associated with the glornerular filtration rate, suggesting that inadequate production of ..
- Instant Pediatric POC Blood AnalysisNEVEN KARLOVAC; Fiscal Year: 2012..by applicant): We propose to develop a Point-of-Care Blood Analyzer that will require ten times smaller blood volume or less and it will provide instant results to improve health of children in health disparity populations...
- Quantitative MR Imaging &Proton Spectroscopy in MS.Yulin Ge; Fiscal Year: 2013..we propose four Specific Aims: Specific Aim 1 defines baseline perfusion (cerebral blood flow;cerebral blood volume;mean transit time), magnetic resonance (MR) spectroscopy (N-acetyl aspartate), and quantitative MR metrics (..
- Mechanisms of Cardiac Function and Cerebral Vascular Control during Heat StressRobert Matthew Brothers; Fiscal Year: 2010..Specific Aim 1: Tests the hypothesis that restoration of central blood volume (indexed by central venous pressure) during heat stress improves blood pressure control and orthostatic ..
- Remote effects of focal hippocampal seizures on neocortical functionHal Blumenfeld; Fiscal Year: 2013..by decreased neuronal firing, CBF, blood oxygen level dependent functional MRI (BOLD fMRI), cerebral blood volume, and metabolism, while at the same time the hippocampus showed increases in all of these measures...
- Mechanisms and relevance of ENaC regulation by EGF and Rac1Alexander Staruschenko; Fiscal Year: 2013..ENaC dysfunction is causative for disturbances in total body Na+ levels associated with abnormal regulation of blood volume, blood pressure, and lung fluid balance...
- Understanding Mechanisms of Resistance to Anti-angiogenic TreatmentsAli Syed Arbab; Fiscal Year: 2013..We expect that treatment resistance tumor will show changes in size, permeability, tumor blood volume, and other MRI parameters...
- Time Resolved Breast Imaging Using a Combined MRI and Optical Tomography ApproachSTEFAN ALEXANDRU CARP; Fiscal Year: 2013..Tissue viscoelastic response to compression causes hemodynamic (blood volume) changes with bi-phasic temporal profiles likely to differentiate healthy tissues from breast lesions...
- FUNCTIONAL MRI DATA AQUISITION AND ANALYSISJames J Pekar; Fiscal Year: 2011..As part of the first aim, we developed a novel method for performing fMRI using cerebral blood volume (CBV) dependent contrast, dubbed "Vascular Space Occupancy (VASO)" fMRI...
- ANP Receptor: Molecular approach of signaling mechanismsKAILASH PANDEY; Fiscal Year: 2009..sodium excretion, fluid volume, and vasorelaxation, important factors in the control of blood pressure and blood volume. Interaction of ANP with its receptor guanylyl cyclase-A/natriuretic peptide receptor-A (GC-A/NPRA) produces ..
- Multiphoton imaging of the juxtaglomerular apparatusJanos Peti-Peterdi; Fiscal Year: 2013..In this proposal we will directly visualize novel mechanisms in the kidney using a state-of- the-art imaging technology which will allow us to discover how the kidney operates in real time to control blood volume and pressure.
- Phosphorylation-dependent regulation of epithelial sodium channel (ENaC) traffickXiubin Liang; Fiscal Year: 2012..Through this study, we will advance our understanding of molecular mechanisms of ENaC regulation and the results will provide further insight into the control of sodium balance, blood volume and thereby of blood pressure.
- IMAGING BIOMARKERS FOR RADIATION-INDUCED NECROSISJoel Richard Garbow; Fiscal Year: 2013..that are sensitive to important physiologic and cellular parameters, including cell density, cerebral blood volume and flow, oxygen utilization, and vascular permeability or leakiness...
- Placental Insufficiency in Transgenic Mouse Model of Preeclampsia and IUGR TERRY KNUD MORGAN; Fiscal Year: 2013..This "physiologic" mouse model fails to increase its blood volume during pregnancy, similar to women with preeclampsia...
- Multiplexed Bead-based In Vitro Pediatric Allergy TestMark Lim; Fiscal Year: 2013..D., Director of the Allergy Program at Children's Hospital, Boston, Associate Professor of Pediatrics, Harvard Medical School, who will provide consulting and validated blood samples under IRB approval (see letter of support). ..
- Dopamine-B-Hydroxylase in Human Cardiovascular ControlDAVID HERLIE ROBERTSON; Fiscal Year: 2012..This knowledge will permit trials of treatment targeted at making the blood volume normal and improving symptoms in these patients PROJECT NARRATIVE Postural tachycardia syndrome (POTS) is a ..
- Multi-center Structural &Functional Quantitative CT Pulmonary PhenotypingERIC ALFRED HOFFMAN; Fiscal Year: 2012..xenon gas or a slow peripheral injection of iodinated contrast agent to assess regional ventilation or perfused blood volume (PBV)...
- CORD BLOOD COLLECTION DEVICERICHARD MEYST; Fiscal Year: 2009..In addition to measuring total collected blood volume and evaluating sterility for each unit, we will perform cell counts, diff, with NRBC, Viability (Trypan blue), ..
- Exercise, Age-Related Memory Decline, and Hippocampal Function.Scott A Small; Fiscal Year: 2013..is differentially targeted by cognitive aging and 2) that exercise improves DG function, we also use fMRI to test whether exercise-induced improvement in cognitive function is mediated by increased cerebral blood volume to the DG.
- Development of a Fiberless Transflectance Noninvasive Glucose MonitorStevan Kun; Fiscal Year: 2012..of the microcirculatory capillary arcades to refine detection and quantification of microcirculatory blood volume variation patterns during measurement;2) develop a new method to precisely measure plasma volume variation ..
- Kidney Injury and Dysfunction Support (KIDS)Matthew Paden; Fiscal Year: 2010..priming, reduction of the extracorporeal volume to an appropriate size (<15% of a patient's calculated blood volume), while maintaining acceptable hemolysis and thrombosis risks...
- CHEMISTRY AND SPECTROSCOPY OF COPPER MONOOXYGENASESNinian J Blackburn; Fiscal Year: 2012..including embryonic development, stress response, pain, digestion, bone mineralization, sexual response, blood volume and pressure, and many others...
- Regulation of ENaC by phosphoinositides, MARCKS, and the cytoskeletonABDEL AYUBE ALLI; Fiscal Year: 2012..by applicant): The epithelial sodium channel (ENaC) plays an important role in maintaining sodium balance, blood volume, and blood pressure...
- CT Method Development for Quantifying Myocardial Microvascular Flow DistributionERIK LEO RITMAN; Fiscal Year: 2013..myocardium will be subjected to nROI analysis and used to compute the spatial distribution of intramyocardial blood volume and flow and the results will be calibrated by the distribution of flow and intraluminal blood volume as ..
- Imaging the Mitochondrial Response to Neural ActivityRoger J Springett; Fiscal Year: 2010..reconstruction algorithms based on a rapid Monte Carlo forward model, (iii) Develop methods to image total blood volume and tissue hematocrit and test the hypothesis that changes in the tissue hematocrit are insensitive to changes ..
- Biophysical Basis of Muscle Functional MRIBruce M Damon; Fiscal Year: 2013..in skeletal muscle that we built during the last funding period and integrate these methods with perfusion and blood volume measurements for a comprehensive characterization of oxygen delivery and use by exercising muscle...
- Mechanically Stable Blood SubstitutesAndre Francis Palmer; Fiscal Year: 2010..3) Physiological assessment of the hemodynamic effects of various blood volume replacement regimens using LEAcHb dispersions...
- Calcium-related Neurotoxicity of CocaineYingtian Pan; Fiscal Year: 2013..1) dual-wavelength laser speckle imaging to enable concurrent detection of cerebral blood flow (CBF), blood volume (CBV), and tissue hemoglobin oxygenation (StO2) at high spatiotemporal resolutions across a large field of view,..
- Physiology of Inflammatory Arthritis in High ResolutionXueding Wang; Fiscal Year: 2013..has the unique capability to quantify tissue hemodynamic properties including regional blood oxygenation and blood volume, both abnormal in synovial tissue associated with inflammatory arthritis...
- QUANTIFYING KIDNEY INJURY AND INFLAMMATION WITH FLUORINE (19F) MRISamuel A Wickline; Fiscal Year: 2013..We contend that the combination of adjunctive image-based functional and molecular readouts of regional blood volume, oxygenation, and inflammation could enhance these new urinary biomarkers to fully quantify the renal risk ..
- Development and Validation of a High Risk and Potential Newborn Screening for InhEdwin W Naylor; Fiscal Year: 2013..Such DNA sequencing test is also impractical because it requires significant blood volume that exposes an infant to risk from blood loss...
- Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac SurgeryOLA ARVID SELNES; Fiscal Year: 2013..proposal is to evaluate whether near infrared reflectance spectroscopy can be used to trend changes in cerebral blood volume and provide a reliable monitor of vascular reactivity (the hemoglobin volume index)...
- Recombinant annexin A2 plus tPA for combination stroke therapyXiaoying Wang; Fiscal Year: 2013..determine recanalization and reocclusion, MRI CBF to map cerebral blood flow;and MRI measurements of cerebral blood volume (CBV), microvascular volume (MVV), and vessel size index (VSI) to quantify vascular responses to thrombolytic ..
- Non-contrast 4-D Dynamic MRA in Arteriovenous Malformation (AVM)DANNY JIONG JIONG WANG; Fiscal Year: 2013..Furthermore, hemodynamic parameters such as blood flow, blood volume and mean transit time can be quantified by adapting the standard tracer kinetic model...
- Central nervous system plasticity in sympathoinhibition in pregnancyCheryl M Heesch; Fiscal Year: 2012Project Summary: In normal pregnancy resetting of volume control systems maintains elevated blood volume, and arterial baroreflex control of sympathetic outflow is adapted to protect against hypertension, at the expense of compensatory ..
- Cross Species Imaging of SchizophreniaScott A Schobel; Fiscal Year: 2012..Arterial Spin Labeling (ASL), and Magnetic Resonance Spectroscopy (MRS), to complement ongoing Cerebral Blood Volume [CBV] studies...
- QUANTITATIVE BOLD CONTRAST IN HEALTH AND DISEASEDmitriy A Yablonskiy; Fiscal Year: 2012..qBOLD) in MRI that analytically connects BOLD MRI signal to hemodynamic parameters, such as deoxygenated blood volume (DBV) and oxygen extraction fraction (OEF)...
- Noninvasive neonatal glucose monitorROSE MARIE VISCARDI; Fiscal Year: 2012..of accuracy at low glucose;presence of interfering substances found only in neonates;the limited neonatal blood volume that precludes multiple blood collection;their underdeveloped immune response;and the long term consequences of ..
- Differential Approach to the Postural Tachycardia SyndromeWolfgang Singer; Fiscal Year: 2013..Methods will include microneurography, blood volume estimation, exercise testing, and measurements of nerve fiber density and plasma catecholamine's...
- Optical monitoring of cerebral oxygenation in infantsMaria Angela Franceschini; Fiscal Year: 2012..Frequency-domain near-infrared spectroscopy (FD-NIRS) provides bedside monitoring of regional cerebral blood volume and oxygenation, while diffuse correlation spectroscopy (DCS) measures regional cerebral blood velocity...
- Noninvasive assessment of microvascular function in agingJill M Slade; Fiscal Year: 2013..Our studies have shown that muscle BOLD responses are sensitive to blood volume and oxygenation changes and are increased in magnitude in young endurance trained adults when compared to ..
- Mouse fMRI and Calcium Dynamics in Alzheimer's PathophysiologyHerman Moreno; Fiscal Year: 2010..Some fMRI protocols, such as those designed to measure cerebral blood volume (CBV), are especially sensitive to long term metabolic changes in the brain caused by neurodegenerative disease...
- PHYSIOLOGICAL BASIS OF FUNCTIONAL MRIRICHARD BRUCE BUXTON; Fiscal Year: 2012..mathematical model for the BOLD response that includes effects of intravascular signal change and arterial blood volume changes, and test an alternative hyperoxia technique for calibration as an alternative to hypercapnia (Aim 4)...
- In Vivo Myocardial Microcirculatory FunctionERIK LEO RITMAN; Fiscal Year: 2010..disturbance within the myocardium, have shown that: (a) myocardial perfusion (F) and intramyocardial blood volume (Bv) can be quantitated using an intravenous bolus injection of contrast medium; (b) the myocardial blood ..
- Predictive experiment-based multiscale models of angiogenesis in breast cancerAleksander S Popel; Fiscal Year: 2013..and microvasculature in growing tumor;and functional characteristics of the tumor microvasculature such as blood volume and vascular permeability, and the extracellular matrix...
- Does strial microischemia enhance cochlear aminoglycoside ototoxicityHongzhe Li; Fiscal Year: 2013..Aim 2: determine the effect of hypertension or age in inducing strial micro-leakage, by increasing blood volume in CBA/CaJ mice...
- Quantification of Tumor Malignancy with MRIFernando E Boada; Fiscal Year: 2013..Dynamic, susceptibility-weighted contrast-enhanced MRI (DSC MRI) will be used to measure relative cerebral blood volume (rCBV) and the vascular permeability-surface area product (PS)...
- OXYGEN TRANSPORT CYS CELL FREE HEMOGLOBINRobert Winslow; Fiscal Year: 2002..of hemoglobin elicit a range of physiological effects from vasoactivity and acid-base status to changes in blood volume in animals...
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2004..remain entirely within the intravascular space, contrast-enhanced ultrasound can also be used to measure the blood volume fraction (MBV)...
- ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONSanjiv Kaul; Fiscal Year: 2002..remain entirely within the intravascular space, contrast-enhanced ultrasound can also be used to measure the blood volume fraction (MBV)...
- ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTSAli Ehsani; Fiscal Year: 2000..of cardiac output, total peripheral resistance, arterial stiffness, sympathetic nervous system activity, and blood volume; (3) to determine whether exercise-training can (a) induce regression or reduction of LVH, (b) improve left ..
- Functional brain imaging by laser-induced PATLihong Wang; Fiscal Year: 2007..Besides structural information, the proposed fPAT can also provide functional information including blood volume and blood oxygenation...
- DETERMINANTS OF SODIUM RETENTION IN CIRRHOSISWILLIAM RECTOR; Fiscal Year: 1992..Total blood volume (BV) is not reduced in such patients, but mean arterial pressue (MAP) and systemic vascular resistance (SVR) ..
- LUNG GROWTH AT HIGH ALTITUDE AND MAXIMAL O2 TRANSPORTRobert Johnson; Fiscal Year: 2005..structural changes can be isolated only after re-acclimatization to sea level (SL) when reversible changes in blood volume and pulmonary vascular reactivity have subsided...
- RICKETTSIAL EFFECTS ON ENDOTHELIAL FUNCTIONSThomas Walker; Fiscal Year: 1990..The results of these changes are hypotension decreased blood volume, tissue anoxia, and shock due to peripheral vascular collapse...