up regulation


Summary: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Top Publications

  1. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
  2. ncbi Silencing of microRNAs in vivo with 'antagomirs'
    Jan Krutzfeldt
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 438:685-9. 2005
  3. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
  4. ncbi A trip to the ER: coping with stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Trends Cell Biol 14:20-8. 2004
  5. pmc Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 16:2481-98. 2004
  6. pmc MicroRNA-155 is induced during the macrophage inflammatory response
    Konstantin D Taganov
    Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:1604-9. 2007
  7. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
  8. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
  9. ncbi Characterization of microRNA expression levels and their biological correlates in human cancer cell lines
    Arti Gaur
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03755, USA
    Cancer Res 67:2456-68. 2007
  10. ncbi Human FOX gene family (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1495-500. 2004

Detail Information

Publications383 found, 100 shown here

  1. pmc Significance analysis of microarrays applied to the ionizing radiation response
    V G Tusher
    Departments of Medicine and Biochemistry, Stanford University, 269 Campus Drive, Center for Clinical Sciences Research 1115, Stanford, CA 94305-5151, USA
    Proc Natl Acad Sci U S A 98:5116-21. 2001
    ..Surprisingly, four nucleotide excision repair genes were induced, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation...
  2. ncbi Silencing of microRNAs in vivo with 'antagomirs'
    Jan Krutzfeldt
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 438:685-9. 2005
    ..Our findings show that antagomirs are powerful tools to silence specific miRNAs in vivo and may represent a therapeutic strategy for silencing miRNAs in disease...
  3. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
  4. ncbi A trip to the ER: coping with stress
    D Thomas Rutkowski
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Trends Cell Biol 14:20-8. 2004
    ..This review highlights advances in these areas and attempts to forecast important issues that must be addressed soon...
  5. pmc Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 16:2481-98. 2004
    ..However, erd1 was not upregulated in the transgenic plants. Other interacting factors may be necessary for the induction of erd1 in Arabidopsis under stress conditions...
  6. pmc MicroRNA-155 is induced during the macrophage inflammatory response
    Konstantin D Taganov
    Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:1604-9. 2007
    ..Importantly, because miR-155 is known to function as an oncogene, these observations identify a potential link between inflammation and cancer...
  7. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
    ..Thus, the DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells...
  8. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  9. ncbi Characterization of microRNA expression levels and their biological correlates in human cancer cell lines
    Arti Gaur
    Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03755, USA
    Cancer Res 67:2456-68. 2007
    ..These findings call attention to the potential of microRNAs to provide etiologic insights as well as to serve as both diagnostic markers and therapeutic targets for many different tumor types...
  10. ncbi Human FOX gene family (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1495-500. 2004
  11. ncbi A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
    ..The physiologic functions of the other MRPs are not known. Whether long-term inhibition of MRPs in humans can be tolerated (assuming that suitable inhibitors will be found) remains to be determined...
  12. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  13. ncbi Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
    Esmerina Tili
    Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Immunol 179:5082-9. 2007
    ..Altogether, our data suggest that the LPS/TNF-alpha-dependent regulation of miR-155 and miR-125b may be implicated in the response to endotoxin shock, thus offering new targets for drug design...
  14. ncbi Relief of microRNA-mediated translational repression in human cells subjected to stress
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    Cell 125:1111-24. 2006
    ..We propose that proteins interacting with the 3'UTR will generally act as modifiers altering the potential of miRNAs to repress gene expression...
  15. pmc Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
    Fengrong Zuo
    Roche Bioscience, Palo Alto, CA 94304 Functional Genomics, and Institute of Respiratory Medicine, Sheba Medical Center, Tel Hashomer, 52621 Israel
    Proc Natl Acad Sci U S A 99:6292-7. 2002
    ..They also illustrate the power of global gene expression analysis of human tissue samples to identify molecular pathways involved in clinical disease...
  16. pmc Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression
    Rong Shao
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3992-4003. 2004
    ..These findings demonstrate the presence of a novel mechanism by which tumor angiogenesis is acquired with the expression of a mesenchyme-specific gene as a crucial step in late stages of tumorigenesis...
  17. ncbi Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice
    Hui Yang Zeng
    Peking University Eye Centre, Peking University Third Hospital, Beijing, China
    Invest Ophthalmol Vis Sci 46:2992-9. 2005
    ..To elucidate the role of activated microglia in the photoreceptor apoptosis of rd mice by identifying sequential events and factors associated with microglial activation, migration, and cytotoxicity during retinal degeneration...
  18. pmc Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    Aparna C Ranganathan
    Department of Biomedical Sciences, School of Public Health and Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Cancer Res 66:1702-11. 2006
    ..We propose that stress-dependent activation of p38 via BiP up-regulation and PERK activation protects dormant tumor cells from stress insults, such as chemotherapy...
  19. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  20. pmc Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
    Fletcher A White
    Department of Cell Biology, Neurobiology, and Anatomy, and Anesthesiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 102:14092-7. 2005
    ..MCP-1/CCR2 signaling is directly involved with a chronic compression injury and may contribute to associated neuronal hyperexcitability and neuropathic pain...
  21. ncbi Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    Yoshiharu Miyamoto
    Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Cell 3:565-76. 2003
    ..These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells...
  22. ncbi TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment
    Zane Orinska
    Department of Immunology and Cellular Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Blood 106:978-87. 2005
    ..Mast-cell reconstitution of KitW/KitW-v mice normalizes the CD8+ T-cell influx. Thus, mast cells stimulated through engagement of TLR3 are potent regulators of CD8+ T-cell activities in vitro and in vivo...
  23. ncbi Fas engagement induces neurite growth through ERK activation and p35 upregulation
    Julie Desbarats
    Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Nat Cell Biol 5:118-25. 2003
    ..Our findings define a role for Fas as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo...
  24. ncbi A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms
    N van Belzen
    Department of Pathology, Erasmus University Rotterdam, The Netherlands
    Lab Invest 77:85-92. 1997
  25. ncbi Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:2760-9. 1998
    ..These different patterns of chemokine receptors are consistent with "inflammatory" and "primary response" phases of DC function...
  26. pmc The role of microRNA genes in papillary thyroid carcinoma
    Huiling He
    Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 102:19075-80. 2005
    ..We conclude that up-regulation of several miRs and regulation of KIT are involved in PTC pathogenesis, and that sequence changes in genes targeted by miRNAs can contribute to their regulation...
  27. ncbi Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
    Rolf I Skotheim
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital and University of Oslo, Norway
    Cancer Res 65:5588-98. 2005
  28. pmc A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
    J R Bischoff
    SUGEN, Inc, Redwood City, California 94063, USA
    EMBO J 17:3052-65. 1998
    ..These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome-associated proteins as novel targets for cancer therapy...
  29. ncbi Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
    Yong Zhao
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell 129:303-17. 2007
    ..These findings indicate that subtle alteration of miRNA dosage can have profound consequences in mammals and demonstrate the utility of mammalian loss-of-function models in revealing physiologic miRNA targets...
  30. ncbi Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
    Francisco J Esteva
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:1800-8. 2002
    ..To evaluate the safety and efficacy of weekly docetaxel plus trastuzumab in women with HER-2-overexpressing metastatic breast cancer. Efficacy was correlated with serum HER-2 extracellular domain (ECD) levels...
  31. pmc Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
    Y Kouzu
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Cancer 94:717-23. 2006
    ..029). These results suggest that expression of stathmin could contribute to cancer progression/prognosis, and that stathmin may have potential as a biomarker and a therapeutic target for OSCC...
  32. pmc Foxo3 is required for the regulation of oxidative stress in erythropoiesis
    Dragan Marinkovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:2133-44. 2007
    ..These results may have an impact on the understanding of human disorders in which ROS play a role...
  33. ncbi A pair of related genes with antagonistic roles in mediating flowering signals
    Y Kobayashi
    Department of Botany, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Science 286:1960-2. 1999
    ..FT acts in part downstream of CO and mediates signals for flowering in an antagonistic manner with its homologous gene, TERMINAL FLOWER1 (TFL1)...
  34. ncbi Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons
    M Tamatani
    Department of Anatomy and Neuroscience, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0872, Japan
    J Biol Chem 274:8531-8. 1999
    ..These findings indicate that induction of Bcl-2 and Bcl-x expression through NFkappaB activation is involved in the neuroprotective action of TNF against hypoxia- or nitric oxide-induced injury...
  35. ncbi Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs
    Jeremy R Graff
    Lilly Research Labs, Cancer Research Division, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Clin Exp Metastasis 20:265-73. 2003
  36. pmc Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia
    Dominique Arion
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 62:711-21. 2007
    ..Schizophrenia is characterized by complex gene expression changes. The transcriptome alterations in the prefrontal cortex have been the subject of several recent postmortem studies that yielded both convergent and divergent findings...
  37. pmc Analysis of microarray data using Z score transformation
    Chris Cheadle
    DNA Array Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21221, USA
    J Mol Diagn 5:73-81. 2003
    ..The results provided by these methods can be as rigorous and are no more arbitrary than other test methods, and, in addition, they have the advantage that they can be easily adapted to standard spreadsheet programs...
  38. pmc HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    Edurne Berra
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    EMBO J 22:4082-90. 2003
    ..Interestingly, PHD2 is upregulated by hypoxia, providing an HIF-1-dependent auto-regulatory mechanism driven by the oxygen tension...
  39. pmc Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse
    B R Miller
    Program in Neuroscience, Department of Psychological and Brain Sciences, 1101 East 10th Street, Bloomington, IN 47405, USA
    Neuroscience 153:329-37. 2008
    ..The glutamate uptake deficit, moreover, is present in symptomatic HD mice and reversal of this deficit by up-regulating the functional expression of GLT1 with ceftriaxone attenuates the HD phenotype...
  40. pmc Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries
    Marie Henriksson
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Lund, Sweden
    Br J Pharmacol 142:1155-61. 2004
    ..Since there is a similar upregulation in models of focal ischaemia and subarachnoid haemorrhage, this may be an important pathophysiological event...
  41. ncbi Isolation and characterization of a termite transferrin gene up-regulated on infection
    Graham J Thompson
    School of Tropical Biology, James Cook University, Townsville, Queensland, Australia
    Insect Mol Biol 12:1-7. 2003
    ..Thus, unlike certain vertebrate transferrin lineages, no widespread evidence for pathogen-mediated positive selection was detected at this locus...
  42. ncbi Mitochondrial transcription factor A regulates mtDNA copy number in mammals
    Mats I Ekstrand
    Department of Medical Nutrition, Karolinska Instititutet, Novum, S 141 86 Stockholm, Sweden
    Hum Mol Genet 13:935-44. 2004
    ..In conclusion, our results provide genetic evidence for a novel role for TFAM in direct regulation of mtDNA copy number in mammals...
  43. pmc Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
    Marina Bousquet
    Institut National de Santé et de Recherche Médicale, U563, Centre de Physiopathologie de Toulouse Purpan, 31300 Toulouse, France
    J Exp Med 205:2499-506. 2008
    ..Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2;11) translocation define a new clinicopathological entity...
  44. pmc Activation of Notch signaling pathway precedes heart regeneration in zebrafish
    Angel Raya
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:11889-95. 2003
    ..Advances in these fields will undoubtedly aid in the implementation of strategies for regenerative medicine...
  45. ncbi Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    A Peled
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Science 283:845-8. 1999
    ..Thus, up-regulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation...
  46. ncbi Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
    Stephen K Tahir
    Global Pharmaceutical Product Research Division, Abbott Laboratories, Abbott Park Road, Abbott Park, IL 60064, USA
    Cancer Res 67:1176-83. 2007
    ..Overall, these observations provide further insight as to the mechanistic bases for ABT-737 efficacy in SCLC and will be helpful for profiling patients and aiding in the rational design of combination therapies...
  47. pmc Extensive post-transcriptional regulation of microRNAs and its implications for cancer
    J Michael Thomson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 20:2202-7. 2006
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer...
  48. ncbi Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation
    Yaara Ben-Yosef
    Neuroimmunology Unit, Carmel Medical Center, Haifa, Israel
    Circ Res 90:784-91. 2002
    ..Prolonged hypoxia of ECs appears to enhance MMP-2 production and secretion, whereas reoxygenation further increases its level. These H/R-mediated effects on MMPs have the potential of enabling EC migration and possible angiogenesis...
  49. pmc Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer
    E Angst
    Department of Clinical Research, Visceral and Transplant Surgery, University Hospital Bern, Murtenstrasse 35, Bern 3010, Switzerland
    Br J Cancer 95:307-13. 2006
    ..Furthermore, we present the novel finding that cellular differentiation may be an important factor that determines the hypoxia-induced regulation of NDRG1...
  50. ncbi HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages
    Elena Izmailova
    Department of Medicine, Children s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 9:191-7. 2003
    ..These results show that HIV-1 Tat reprograms host dendritic cell gene expression to facilitate expansion of HIV-1 infection...
  51. ncbi Monitoring expression profiles of Arabidopsis gene expression during rehydration process after dehydration using ca 7000 full-length cDNA microarray
    Youko Oono
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Plant J 34:868-87. 2003
    ..Functional analysis of rehydration-inducible and rehydration-repressed genes revealed their functions not only in the release from a stressed status but also in the recovery of growth in plants...
  52. ncbi Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas
    Yu Min Lin
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 21:4120-8. 2002
  53. ncbi Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production
    Olivera M Grbovic
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Biol Chem 278:31261-8. 2003
    ..Our findings in this model system suggest that the endosomal pathology seen at the earliest stage of sporadic AD may contribute to APP proteolysis along a beta-amyloidogenic pathway...
  54. ncbi HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    Ioanna Papandreou
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Metab 3:187-97. 2006
  55. ncbi Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis
    Yongjun Wang
    Center for Musculoskeletal Research, Department of Orthopeadics, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 20:1624-36. 2005
    ..Runx1 induces mesenchymal stem cell commitment to the early stages of chondrogenesis...
  56. ncbi HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma
    Sandra Turcotte
    Laboratoire de Medecine Moleculaire, Hopital Sainte Justine, Universite du Quebec a Montreal, CP 8888, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3P8
    J Cell Sci 116:2247-60. 2003
    ..Together, these results support a model where ROS upregulate Rho protein expression and where active RhoA is required for HIF-1alpha accumulation during hypoxia...
  57. pmc Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning
    Sadie L Smith
    Center for Regenerative Biology Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA
    Proc Natl Acad Sci U S A 102:17582-7. 2005
  58. ncbi Gene signatures of progression and metastasis in renal cell cancer
    Jon Jones
    Beth Israel Deaconess Medical Center Genomics Center and Dana Farber Harvard Cancer Center Proteomics Core, Boston, Massachusetts 02115, USA
    Clin Cancer Res 11:5730-9. 2005
    ..To address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC)...
  59. ncbi Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells
    Fenghuang Zhan
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Blood 99:1745-57. 2002
    ..Thus, novel candidate MM disease genes have been identified using gene expression profiling and this profiling has led to the development of a gene-based classification system for MM...
  60. ncbi Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)
    Laura A Strickland
    Department of Pathology, Genentech Inc, South San Francisco, CA, USA
    J Pathol 206:466-75. 2005
    ..We suggest that PLVAP is a downstream target of VEGF signalling. This work solidifies the association between VEGF and the appearance and maintenance of fenestrations by providing a potential mechanistic link...
  61. ncbi Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
    Guang Xian Zhang
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Immunol 170:2153-60. 2003
  62. ncbi Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery
    Yong xiao Cao
    Division of Experimental Vascular Research, Department of Medicine, Lund University, Sweden
    Basic Clin Pharmacol Toxicol 96:282-8. 2005
    ..These data reveal a role of ERK1/2 in up-regulation of 5-HT2A receptors and suggest a possibility to inhibit the enhanced responses to 5-HT by inhibition of the ERK1/2 pathway...
  63. pmc Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation
    Hua Shen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 181:1849-58. 2008
    ..In sum, in our experimental systems, TRIF signaling plays a more important role in LPS-induced macrophage activation than in DC activation...
  64. pmc Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system
    Catherine I Dubreuil
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC H3T 1J4, Canada
    J Cell Biol 162:233-43. 2003
    ..Experiments with p75NTR-null mutant mice showed that immediate Rho activation after SCI is p75NTR dependent. Our results indicate that blocking overactivation of Rho after SCI protects cells from p75NTR-dependent apoptosis...
  65. ncbi Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum
    James F Collins
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, 1501 N Campbell Ave, Tucson, Arizona 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G964-71. 2005
    ..These findings may thus explain copper loading in the iron-deficient state. We also demonstrate that many other novel genes may be differentially regulated in the setting of iron deprivation...
  66. ncbi Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells
    Sun Ryung Lee
    Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Korea
    J Cell Physiol 205:270-7. 2005
    ..These results suggest that Akt facilitate cell-cycle progression at G2/M phase in PC12 cells and this Akt activity is correlated with upregulation of NF-Y DNA-binding activity and cyclin B1/CDK1 gene expression...
  67. ncbi Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure
    H Kawai
    Neurobiology Section, Division of Biology, University of California, San Diego, La Jolla, California 92093-0357, USA
    J Neurochem 78:1367-78. 2001
  68. pmc Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis
    Douglas R Hurst
    Department of Pathology, Comprehensive Cancer Center, and National Foundation for Cancer Research, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 69:1279-83. 2009
    ..These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis...
  69. ncbi Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    M Tsujii
    Department of Medicine, Vanderbilt University Medical Center, VA Medical Center, Nashville, Tennessee 37232, USA
    Cell 93:705-16. 1998
    ..Cyclooxygenase regulates colon carcinoma-induced angiogenesis by two mechanisms: COX-2 can modulate production of angiogenic factors by colon cancer cells, while COX-1 regulates angiogenesis in endothelial cells...
  70. ncbi The proto-oncoprotein c-Fos negatively regulates hepatocellular tumorigenesis
    Mario Mikula
    Institute of Cancer Research, University of Vienna, Borschke Gasse 8a, A 1090 Vienna, Austria
    Oncogene 22:6725-38. 2003
    ..Taken together, we demonstrate that c-Fos modulates plasticity of epithelial hepatocytes and acts tumour suppressive in neoplastic hepatocytes by stimulating cell cycle inhibition and cell death...
  71. pmc Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta
    Baojie Li
    Institute of Molecular and Cell Biology, Proteos Singapore 138673
    Genes Dev 18:1824-37. 2004
    ..Hence, our results unveiled a previously unrecognized mechanism by which c-Abl and Atm participate in oxidative stress response...
  72. ncbi BCG dose reduction by decreasing the instillation frequency: effects on local Th1/Th2 cytokine responses in a mouse model
    Elizabeth C De Boer
    Department of Urology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur Urol 48:333-8. 2005
  73. ncbi hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    M Meyerson
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Cell 90:785-95. 1997
    ..Taken together, these observations suggest that the induction of hEST2 mRNA expression is required for the telomerase activation that occurs during cellular immortalization and tumor progression...
  74. ncbi FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis
    Mani Alikhani
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:12096-102. 2005
    ..siRNA silencing also blocked down-regulation of anti-apoptotic genes. These results indicate that TNF induces activation of the FOXO1 transcription factor, which acts as a master switch to control apoptosis...
  75. ncbi GP73, a novel Golgi-localized protein upregulated by viral infection
    R D Kladney
    Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, MO 63106, USA
    Gene 249:53-65. 2000
    ..We conclude that GP73 represents a novel, epithelial cell-specific integral membrane Golgi protein that can be upregulated in response to viral infection...
  76. ncbi Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain
    Jill A Lindia
    Department of Pharmacology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Pain 6:434-8. 2005
    ..However, after spinal nerve injury, CX3CR1-LI was upregulated in microglia throughout the dorsal horn...
  77. ncbi Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees
    Sabrina Semprini
    Cattedra di Genetica, Edificio E Nord, piano terra, Universita di Roma Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Hum Genet 111:310-3. 2002
    ..Thus, our data provide preliminary evidence for a locus-specific molecular mechanism underlying psoriasis susceptibility...
  78. ncbi Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
    ..Our results define a complex molecular program that links gene transcription induced by calcium and calcineurin to a paradoxical impairment of signal transduction in anergic T cells...
  79. ncbi Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity
    Keisuke Shioji
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan
    Circulation 106:1403-9. 2002
    ..Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity...
  80. ncbi NDRG1 is necessary for p53-dependent apoptosis
    Susanne Stein
    Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:48930-40. 2004
    ..This report further supports the notion that p53 controls a network of genes that are required for its apoptotic function...
  81. ncbi Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
    Sarah J Ballantyne
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Allergy Clin Immunol 120:1324-31. 2007
    ..Its roles in antigen-driven airway inflammation and airway hyperresponsiveness (AHR) remain to be fully established...
  82. ncbi The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
    C C Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Ave, Chicago, IL 60607 7170, USA
    J Biol Chem 276:47329-37. 2001
    ..We propose a model in which Cyr61 integrates its activities on endothelial cells, fibroblasts, and macrophages to regulate the processes of angiogenesis, inflammation, and matrix remodeling in the context of cutaneous wound healing...
  83. pmc RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins
    Shu Xiao
    Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, Rui Jin Hospital, Health Science Center, Chinese Academy of Sciences and School of Medicine, Shanghai Jiao Tong University, 197 Rui Jin Road II, Shanghai 200025, China
    Proc Natl Acad Sci U S A 103:16448-53. 2006
  84. ncbi The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    Antje Blumenthal
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Blood 108:965-73. 2006
    ..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections...
  85. ncbi Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells
    Shenglin Huang
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Medical School of Shanghai Jiaotong University, Shanghai, China
    Int J Cancer 123:972-8. 2008
    ..These findings suggest a novel, alternative mechanism through which TGF-beta could induce specific miRNA expression to escape from tumor-suppressive response in HCC cells...
  86. ncbi Up-regulation of inhibitory natural killer receptors CD94/NKG2A with suppressed intracellular perforin expression of tumor-infiltrating CD8+ T lymphocytes in human cervical carcinoma
    Bor Ching Sheu
    Department of Obstetrics and Gynecology, National Taiwan University Hospital and Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan
    Cancer Res 65:2921-9. 2005
    ..Our study strongly indicated that cervical cancer cells could promote the expression of iNKRs via an IL-15- and possibly TGF-beta-mediated mechanism and abrogate the antitumor cytotoxicity of TILs...
  87. ncbi Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis
    Imad J Matouk
    Department of Biology, Science and Technology, Alquds Abu Dis University, Jerusalem, Israel
    Eur J Gastroenterol Hepatol 21:688-92. 2009
    ..It is specifically expressed in the hepatocytes with striking upregulation in hepatocellular carcinoma (HCC)...
  88. ncbi Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
    C Fleury
    CNRS CEREMOD, Meudon, France
    Nat Genet 15:269-72. 1997
    ..Our findings suggest that UCP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli...
  89. pmc Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
    Barbara Lustig
    Max Delbrueck Center for Molecular Medicine, D 13092 Berlin, Germany
    Mol Cell Biol 22:1184-93. 2002
    ..These results demonstrate that conductin is a target of the Wnt signaling pathway. Upregulation of conductin may constitute a negative feedback loop that controls Wnt signaling activity...
  90. ncbi Extracellular matrix metalloproteinase inducer up-regulates the urokinase-type plasminogen activator system promoting tumor cell invasion
    Cathy Quemener
    Institut National de la Sante et de la Recherche Medicale U716, Universite Paris 7, Paris, France
    Cancer Res 67:9-15. 2007
    ..These data show a novel regulatory pathway for uPA activity and suggest that EMMPRIN is involved in uPA dysregulation observed in cancer...
  91. ncbi Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    Loic Guillot
    Unité de Défense Innée et Inflammation, INSERM E336, Paris, France
    J Biol Chem 280:5571-80. 2005
  92. ncbi Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 180:4697-705. 2008
    ..Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen...
  93. ncbi T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC
    Deanna Haasch
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Cell Immunol 217:78-86. 2002
    ..Tam, Gene 274 (2001) 157). Our data demonstrate that transcriptional activation of the BIC proto-oncogene is an early and sustained T cell activation event and suggest an important role for noncoding mRNA in T cell function...
  94. ncbi Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
    Della C David
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 280:23802-14. 2005
    ..Taken together, we conclude that tau pathology involves a mitochondrial and oxidative stress disorder possibly distinct from that caused by Abeta...
  95. ncbi Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    Joshua J McElwee
    Department of Biology, University College London, WC1E 6BT, United Kingdom
    J Biol Chem 279:44533-43. 2004
    ..By contrast, the daf-16-associated element was enriched in genes down-regulated in dauers and daf-2 mutants. Thus, particular promoter elements appear longevity-associated or aging associated...
  96. ncbi Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia
    Clin Cancer Res 10:4427-36. 2004
    ..The aims of this study were to integrate the results from 14 transcript profiling studies of EOC to identify novel biomarkers and to examine their expression in early and late stages of the disease...
  97. pmc NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization
    Tim Raemaekers
    Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Cell Biol 162:1017-29. 2003
    ..In addition, many NuSAP-depleted interphase cells had deformed nuclei. Both overexpression and knockdown of NuSAP impaired cell proliferation. These results suggest a crucial role for NuSAP in spindle microtubule organization...
  98. ncbi SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
    B Emanuelli
    INSERM U145, IFR 50, , 06107 Nice Cedex 2, France
    J Biol Chem 276:47944-9. 2001
    ..As SOCS-3 appears as a TNF-alpha target gene that is elevated during obesity, and as SOCS-3 antagonizes insulin-induced IRS-1 tyrosine phosphorylation, we suggest that it is a player in the development of insulin resistance...
  99. pmc Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
    Aleksandra Franovic
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5
    Proc Natl Acad Sci U S A 104:13092-7. 2007
    ..Taken together, our findings provide a nonmutational explanation for EGFR overexpression in human tumors and highlight a role for HIF2alpha activation in the regulation of EGFR protein synthesis...
  100. ncbi GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
    Bernardo Yusta
    Department of Medicine, Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Metab 4:391-406. 2006
    ..These findings demonstrate that GLP-1R signaling directly modulates the ER stress response leading to promotion of beta cell adaptation and survival...
  101. ncbi Trypanosoma brucei infection induces apoptosis and up-regulates neuroleukin expression in the cerebellum
    J K Stiles
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, 720 Westview Dr S W, Atlanta, GA 30310 1495, USA
    Ann Trop Med Parasitol 95:797-810. 2001
    ..NLK may be modulating inflammation and is probably involved in protecting CN and the cerebellum against apoptosis...

Research Grants72

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
  2. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..The long term potential of the proposed research is significant, as understanding the mechanisms by which TRM9 inhibits tumor growth may provide novel therapeutic opportunities to restore growth-restricting programs in cancer cells. ..
  3. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
  4. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
  5. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
  6. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
  7. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
  8. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
  9. Regulation of the Vibrio cholerae intestinal exit plan
    ANISIA J SILVA BENITEZ; Fiscal Year: 2010
    ..cholerae detachment and the role of protease production and motility in this process. These studies could open new avenues to treat cholera and shed light on the epidemic potential of this pathogen. ..
  10. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..If successful, such beneficial outcomes may improve the health of veterans with acute ischemic syndromes during cardiac transplantation, coronary bypass surgery, and other acquired cardiac conditions. ..
  11. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..abstract_text> ..
    Howard B Lieberman; Fiscal Year: 2013
    ..Recently, we discovered a very novel regulatory pathway that causes aberrant up regulation of Rad9 in prostate cancer...
  13. Mechanisms of virus-induced injury in the brain and spinal cord
    Kenneth L Tyler; Fiscal Year: 2013
  14. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..can activate Peroxisome proliferator- activated receptor coactivator -1a (PGC-1a) in hepatocytes, resulting in up regulation of enzymes related to fatty acids beta-oxidation and mitochondrial biogenesis...
  15. Improving Epigenetic-based Cell Reprogramming with Proteasome Inhibition
    Jaroslaw Staszkiewicz; Fiscal Year: 2011
  16. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders. ..
  18. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
  19. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..b>Up regulation of Na? exchanger-1 (NHE-1), previously demonstrated in several tissue-sites for diabetes complications, causes ..
  20. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..This proposal explores the therapeutic potential of D609 and how it affects lipid second messenger ceramide that regulates the cell cycle both in vitro and in vivo stroke models. ..
  21. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..We have demonstrated that bone marrow origin macrophages migrate to the mouse lung at the time of up regulation of endothelial cell VCAM-1 and ICAM-1 at 120-140 days after pulmonary irradiation, followed by TGF2-mediated ..
  22. Non-Alcoholic Fatty Liver Disease and Obstructive Sleep Apnea: Mechanistic Links
    ..caused by OSA plays a key role in the pathogenesis of NASH through the initiation of oxidative stress and up regulation of inflammatory pathways...
  23. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
  24. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
  25. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
  26. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..Blocking the effects of H6PDH on 112-HSD1 may represent a new strategy in the effective treatment of type 2 diabetes and obesity through reduction of tissue GC availability mediating insulin sensitivity and glucose homeostasis. ..
  27. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..Knowledge obtained from these studies will guide the application of this abundant and sustainable natural resource in chemoprevention of breast cancer, the most prevalent cancer among women in the United States. ..
  28. Biological Functions of Iron Responsive Elements
    Richard S Eisenstein; Fiscal Year: 2012
  29. Stat3 Downstream Genes as Lung Adenocarcinoma Biomarkers
    Cong Yan; Fiscal Year: 2013
    ..This work will identify protein biomarkers for lung cancer diagnosis and prognosis in humans and in animals. ..
  30. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..
  31. microRNA mediation of Endothelial Progenitor Cell function in Myocardial Ichemia
    Prasanna Krishnamurthy; Fiscal Year: 2013
  32. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..Understanding of the specific factors produced by these lymphocytes that lead to pathogenic autoantibodies production will provide new targets for intervention of this process. ..
  33. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..The knowledge gained from this project will therefore directly result in designing rational therapies for these conditions. ..
  34. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..typhimurium triggers and controls the directed movement of PMN across the epithelial surface so that novel targets for therapeutic intervention in such inflammatory bowel diseases can be identified. ..
  35. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Specific Aim 4 will investigate the role of ACE2/Ang (1-7)/Mas in counteracting ACE/Ang II/AT1 in the efficacy of EPCs transplantation for promoting repair after ischemic stroke. ..
  36. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    Carlos M Ferrario; Fiscal Year: 2013
    ..Understanding the regulation of this system is vital to the prevention of cardiovascular disease as well as in the design of effective therapies to reduce the consequences of the disease. ..
  38. DHA, Inflammation, and Insulin Sensitivity in Obese Pregnant Women
    Debra Krummel; Fiscal Year: 2009
  39. Mechanisms for cell specific modulation of proliferation and migration
    Thomas S Monahan; Fiscal Year: 2013
    ..Monahan is fortunate to be part of a larger vascular biology research team, whose support will contribute to his ability to achieve his long-term goal of performing clinically relevant, basic science research. ..
  40. Molecular Mechanism of Arterial Stiffening
    Zhongjie Sun; Fiscal Year: 2013
    ..Completion of the project may offer a new therapeutic approach for large artery stiffening and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of cardiovascular disease. ..
  41. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..We expect that our findings will lead eventually to the development of new therapies for patients with rheumatic fever, lupus, and related autoimmune diseases. ..
  42. Macrophage AMPK, Inflammation, and Atherosclerosis
    Bingzhong Xue; Fiscal Year: 2013
    ..Completing these studies will greatly improve our knowledge on the role of macrophage AMPK in the protection against inflammation-associated metabolic disorders, including atherosclerosis and insulin resistance. ..
  43. Gene expression responses to air pollution and modification by genetic variation
    Sharine Wittkopp; Fiscal Year: 2013
    ..Additionally, recent experiments showed an up regulation of genes in detoxification pathways in cultured human airway epithelial and vascular endothelial cells exposed ..
    Benjamin L Shneider; Fiscal Year: 2012
    ..These studies will advance our understanding of the regulation of ASBT and provide new ways to understand and treat intestinal and liver diseases. ..
  45. Aging and Apoptosis
    Brian A Herman; Fiscal Year: 2012
    ..2002, Reprint 1). Amongst our findings is that normal aging is accompanied by up regulation of the activity of the intrinsic pathway of apoptosis in regenerative but not differentiated tissues...
  46. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
  47. Inhibition of angiogenesis by thrombospondin-1 (A2)
    JOHN W LAWLER; Fiscal Year: 2012
    ..The goal of the proposed study is to determine how proteins that the body normally uses to limit blood vessel growth work. This knowledge will be used to develop therapeutic approaches for the treatment of cancer. ..
  48. Role of DDR2 in OA-like Pathogenesis in Osteochondrodysplasias
    Yefu Li; Fiscal Year: 2010
    ..This study should not only provide novel insights into the role of DDR2 in the progression of genetic forms of OA, but may shed light on aspects of disease progression in non-genetic forms as well. ..
  49. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..Additionally, we will explore whether the combination of information from the PET images and rating scales can be used to identify even more robustly who will quit smoking with nicotine patch treatment. ..
  50. Modeling distinct neonatal purine metabolism to inform vaccine development
    Ofer Levy; Fiscal Year: 2013
    ..These studies will provide insight into neonatal immunity, establish novel platforms for studying immune ontogeny, assess Ado-refractory adjuvants, and inform neonatal vaccine development. ..
  51. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..A better understanding of how angiogenesis is regulated will aid in development of new and more effective therapies for these blinding diseases, as well as other diseases with a neovascular component. ..
    MARIA INES MORANO; Fiscal Year: 2013
  53. Immunomodulatory Mechanisms of Withafarin A in Her-2 neu breast cancer
    ANNALISE ROXANNE SMITH; Fiscal Year: 2013
    ..The benefit of such a strategy would impact the frequent recurrence of metastases of dormant tumor cells after conventional chemotherapy regimens that can cause tumor relapse and therapeutic failure. ..
    Anthony Carruthers; Fiscal Year: 2012
    ..Our long-term goal is to translate these insights into practical intervention in clinical glycopenia. ..
  55. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..Up-regulation of PRCP may be a target to protect individuals from cardiovascular disease as manifested by hypertension and arterial thrombosis as seen in stroke and MI. ..
  56. The role of regulatory T cells in biliary atresia
    Alexander Miethke; Fiscal Year: 2013
  57. Generating Blood-based Diagnosis for Alzheimer Disease
    Eugenia Wang; Fiscal Year: 2012
    ..being the first such AD diagnostic, indicating not only disease presence, but also its progress (and even drug efficacy monitoring), a huge strate- gic gain for the victims of this costly disease, and our society at large! ..
  58. Improve Wound Healing with HIF-CA5 DNA Vector and Electroporation
    John W Harmon; Fiscal Year: 2010
    ..Building on the promising pre- clinical data generated to date, the objective of the proposed STTR program is to bring the CA5 product candidate into clinical testing. ..
  59. Epigenetic regulation in neuropathic pain
    Zhonghui Guan; Fiscal Year: 2013
    ..studies and our preliminary RNA-seq analysis found that in dorsal root ganglion (DRG), nerve injury induces up regulation of the calcium channel alpaha2delta1 subunit (Cacnalpaha2delta1), which is targeted by the most commonly used ..
  60. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..Therefore, this study is important because it is novel and it will permit us to develop effective therapies to prevent it. (End of Abstract) ..
  61. Integration of sleep/wake network models across multiple temporal and spatial sca
    ANDREW JOHN PHILLIPS; Fiscal Year: 2013
    ..The proposed project will grant Dr. Phillips the necessary protected time to conduct research, achieve the necessary experience, and learn the requisite skills to achieve these long-term goals. ..
  62. The Regulation of Mitochondrial Function by SIRT3
    Qiang Tong; Fiscal Year: 2010
    ..3) To characterize the effect of SIRT3 on mitochondrial superoxide production and hyperglycemia-induced oxidative stress. 4) To investigate the effect of SIRT3 on adipose oxidative stress during obesity and diabetes in vivo. ..
  63. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..This therapeutic approach will reduce killed in action (KIA) rate, increased life saving capability for the medic, and reduce need for surgery and transfusion. [unreadable] [unreadable] [unreadable]..
    R Mulcahy; Fiscal Year: 1999
  65. Development of a human Oct-4 gene-targeted reporter cell line
    GREGORY LENO; Fiscal Year: 2010
    ..Efficiently reprogrammed human cells have viable commercial applications in regenerative medicine. ..
    TERRENCE O BRIEN; Fiscal Year: 2000
    ..that among the cardiocytes initial response to pathologic hemodynamic load, both in vivo and in vitro, is an up regulation of several components of the nuclear and mitochondrially derived mitochondrial oxidative phosphorylation ..
  67. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..5-HT content will be measured by HPLC in brain homogenates. ..
    Natalia Nieto; Fiscal Year: 2012
    ..Such information could lead to positive pharmacological targeting to ameliorate alcohol hepatotoxicity. ..
  69. Modulation of Glucocorticoid-Evoked Lymphocyte Apoptosis by BTG1
    RHEEM MEDH; Fiscal Year: 2007
    ..and resistant, respectively to GC-evoked apoptosis, the PI has obtained preliminary data correlating the up regulation of transcript and protein levels of the anti proliferative gene, Btg1, to G1 arrest and apoptosis...
    Christine M Disteche; Fiscal Year: 2010
    ..Maintenance of the balance of gene expression is critical for normal development, as can be seen from the presence of multiple congenital abnormalities in individuals with chromosomal imbalance due to autosomal monosomy. ..
  71. Role of histone methyltransferases hDOTIL in leukemogenesis
    Yi Zhang; Fiscal Year: 2009
    ..We will map the nuclear localization signal of hDOTIL and the AF10 interaction domains. We will also study how mis-targeting of hDOTIL by CALM-AF10 results in Hox gene upregulation and leukemogenesis. ..
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..