microbial drug resistance
Summary: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Publications239 found, 100 shown here
- Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimuriumJ S Gunn
Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Infect Immun 68:6139-46. 2000....
- Campylobacter jejuni Infections: update on emerging issues and trendsB M Allos
Department of Preventive Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Clin Infect Dis 32:1201-6. 2001..jejuni infection, but its incidence is <1 per 1000 infections. Careful food preparation and cooking practices may prevent some Campylobacter infections...
- Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315Toshiko Ohta
Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennohdai, Tukuba, Ibaraki 305 8575, Japan
DNA Res 11:51-6. 2004..All of the diverse genes and the high quality sequence of Mu50 can be viewed at the web site (http://18.104.22.168/VRSA/)...
- Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial KlebsiellaJ J Rahal
Department of Medicine, New York Hospital Medical Center of Queens and Cornell University Medical College, Flushing 11355, USA
JAMA 280:1233-7. 1998..Resistance to most or all cephalosporin antibiotics in Klebsiella species has developed in many European and North American hospitals during the past 2 decades...
- Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosisA E DeBarber
Tuberculosis Research Section, Laboratory of Host Defenses, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 97:9677-82. 2000..These isolates showed broad cross-resistance to thiocarbonyl containing drugs including ETA, thiacetazone, and thiocarlide...
- Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutationsY Wang
Department of Medical Microbiology, University of Alberta, Edmonton, Canada
Antimicrob Agents Chemother 37:457-63. 1993..The mutation at Thr-86, which is homologous to Ser-83 in Escherichia coli, was associated with high-level resistance to ciprofloxacin in C. jejuni...
- The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistanceD J Austin
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 96:1152-6. 1999..These results highlight the need for early intervention once resistance is detected...
- Vaccine escape recombinants emerge after pneumococcal vaccination in the United StatesAngela B Brueggemann
Department of Zoology, University of Oxford, Oxford, United Kingdom
PLoS Pathog 3:e168. 2007..Vaccine escape by genetic recombination at the capsular locus has the potential to reduce PCV7 effectiveness in the longer term...
- Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operonK Poole
Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
J Bacteriol 175:7363-72. 1993..These data suggest that ORFA-ORFB-oprK (ORFC)-dependent drug efflux contributes to multiple antibiotic resistance in P. aeruginosa. We propose, therefore, the designation mexAB (multiple efflux) for ORFAB...
- DNA gyrase, topoisomerase IV, and the 4-quinolonesK Drlica
Public Health Research Institute, New York, New York 10016, USA
Microbiol Mol Biol Rev 61:377-92. 1997..Thus, quinolone-topoisomerase biology is providing a model for understanding aspects of host-parasite interactions and providing ways to investigate manipulation of the bacterial chromosome by topoisomerases...
- Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistanceM A Ghannoum
Center for Medical Mycology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Clin Microbiol Rev 12:501-17. 1999..For example, modification of enzymes which serve as targets for antimicrobial action and the involvement of membrane pumps in the extrusion of drugs are well characterized in both the eukaryotic and prokaryotic cells...
- The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 A resolutionLuca Federici
Department of Biochemistry, University of Cambridge, United Kingdom
J Biol Chem 280:15307-14. 2005..Our analyses of the external surfaces of VceC and other channel proteins suggest that different classes of efflux pumps have distinct architectures. We discuss the implications of these findings for mechanisms of drug and protein export...
- The rising impact of mathematical modelling in epidemiology: antibiotic resistance research as a case studyL Temime
CNAM, Chaire Hygiène and Sécurité, Paris, France
Epidemiol Infect 136:289-98. 2008..The results of this analysis, which might be applicable to other emerging public health problems, demonstrate the growing interest in mathematical modelling approaches to evaluate antibiotic resistance...
- The tragedy of the commons in antimicrobial chemotherapyF Baquero
Rev Esp Quimioter 16:11-3. 2003
- AcrAB and related multidrug efflux pumps of Escherichia coliH Nikaido
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
J Mol Microbiol Biotechnol 3:215-8. 2001..It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the..
- Predicting the emergence of antibiotic resistance by directed evolution and structural analysisM C Orencia
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Nat Struct Biol 8:238-42. 2001..Our results demonstrate that directed evolution coupled with structural analysis can be used to predict future mutations that lead to increased antibiotic resistance...
- Staphylococcal multidrug efflux protein QacAM H Brown
School of Biological Sciences, University of Sydney, New South Wales, Australia
J Mol Microbiol Biotechnol 3:163-70. 2001..QacR, like the multidrug export protein whose expression it regulates, has been shown to interact directly with a number of structurally-dissimilar compounds...
- Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coliH I Zgurskaya
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3206, USA
Proc Natl Acad Sci U S A 96:7190-5. 1999....
- The natural evolutionary relationships among prokaryotesR S Gupta
Department of Biochemistry, McMaster University Hamilton, Ontario, Canada
Crit Rev Microbiol 26:111-31. 2000....
- Genetic transformation of the Lyme disease agent Borrelia burgdorferi with coumarin-resistant gyrBD S Samuels
Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
J Bacteriol 176:6045-9. 1994..burgdorferi. The coumermycin A1-resistant gyrB marker and genetic transformation can now be applied toward dissecting the physiology and pathogenesis of the Lyme disease agent on a molecular genetic level...
- Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331M E Tolmasky
Department of Microbiology and Immunology L220, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
Plasmid 29:31-40. 1993..Hall, D. Brookes, and H. W. Stokes (1991) Mol. Microbiol. 5, 1941-1959)...
- Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosisH Taniguchi
Department of Microbiology, University of Occupational and Environmental Health, Fukuoka, Japan
FEMS Microbiol Lett 144:103-8. 1996..tuberculosis, and the sites of mutations on the rpoB gene will affect the level of resistance to rifampicin...
- Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteriaH Nikaido
Department of Molecular and Cell Biology, University of California, 229 Stanley Hall, Berkeley, CA 94720 3206, USA
Semin Cell Dev Biol 12:215-23. 2001....
- A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integronsH W Stokes
School of Biological Sciences, Macquarrie University, Sydney, NSW, Australia
Mol Microbiol 3:1669-83. 1989..This family of elements appears formally distinct from other known mobile DNA elements and we propose the name DNA integration elements, or integrons...
- Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331M E Tolmasky
Department of Microbiology and Immunology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
Plasmid 24:218-26. 1990..Tn1331 has 520-bp direct repeats which include parts of the tnpR and TEM bla genes. Evolutionary models for the genesis of Tn1331 are proposed...
- Pharmacodynamics: relation to antimicrobial resistanceMichael J Rybak
Anti Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
Am J Med 119:S37-44; discussion S62-70. 2006..But, further work needs to be done before this conclusion can be verified...
- A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNASubray S Hegde
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Science 308:1480-3. 2005..This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo...
- Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolatesJ Engberg
Department of Gastrointestinal Infections, Division of Diagnostics, Statens Serum Institut, Artillerivej 5, DK 2300 Copenhagen S, Denmark
Emerg Infect Dis 7:24-34. 2001....
- Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamideY Zhang
Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205
J Bacteriol 181:2044-9. 1999..tuberculosis to PZA and that the natural PZA resistance of M. smegmatis is due to a highly active efflux pump. These findings may have implications with regard to the design of new antimycobacterial drugs...
- Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A StreptococcusDavid J Banks
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana 59840, USA
J Infect Dis 188:1898-908. 2003..Together, these data provide new information about the molecular genetic basis of macrolide resistance and dissemination in GAS strains...
- Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosisD L Williams
Gillis W Long Hansen s Disease Research Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70894, USA
Antimicrob Agents Chemother 42:1853-7. 1998....
- Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology networkL McGee
MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
J Clin Microbiol 39:2565-71. 2001..This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks...
- Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferaseAri Robicsek
Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
Nat Med 12:83-8. 2006....
- PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistanceJ S Gunn
University of Washington, Department of Medicine, Seattle 98195, USA
Mol Microbiol 27:1171-82. 1998....
- Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycinK Hiramatsu
Department of Bacteriology, Juntendo University, Tokyo, Japan
Lancet 350:1670-3. 1997..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
- Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit wardMichael G Hughes
Department of Surgery, University of Virginia, Charlottesville 22908, USA
Crit Care Med 32:53-60. 2004..We hypothesized that this intervention would decrease infectious complications in the non-ICU ward to which these patients were transferred...
- Clinical, cellular, and molecular factors that contribute to antifungal drug resistanceT C White
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle Biomedical Research Institute, Washington, USA
Clin Microbiol Rev 11:382-402. 1998..Since the study of antifungal drug resistance is relatively new, other factors that may also contribute to resistance are discussed...
- General practitioners' perceptions of antimicrobial resistance: a qualitative studySharon A Simpson
Department of General Practice, Cardiff University, 3rd Floor Neuadd Merionnydd, Heath Park, Cardiff CF14 4XN, UK
J Antimicrob Chemother 59:292-6. 2007..The aim of this study was therefore to achieve a deeper understanding of GPs' perceptions of antimicrobial resistance...
- Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genesM C Sulavik
Genome Therapeutics Corporation, Waltham, Massachusetts, USA
Antimicrob Agents Chemother 45:1126-36. 2001..The results identify which MDR pumps contribute to intrinsic resistance under the conditions tested and supply practical information useful for designing sensitive assay strains for cell-based screening of antibacterial compounds...
- Invasive pneumococcal disease in England and Wales: vaccination implicationsK Sleeman
Oxford Vaccine Group, John Radcliffe Hospital, Oxford, United Kingdom
J Infect Dis 183:239-246. 2001..The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance...
- Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteriaP M Bennett
Bacterial Genetics, University of Bristol, Bristol, UK
Br J Pharmacol 153:S347-57. 2008..These various aspects of bacterial resistance to antibiotics will be explored in this presentation...
- Korean nationwide surveillance of antimicrobial resistance in 2000 with special reference to vancomycin resistance in enterococci, and expanded-spectrum cephalosporin and imipenem resistance in gram-negative bacilliKyung Won Lee
Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
Yonsei Med J 44:571-8. 2003..In conclusion, the increasing prevalence of resistant bacteria indicates that more concerted effort is required to conserve the usefulness of precious new antimicrobial agents...
- In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferiK P Hunfeld
Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Strasse 40, 60596 Frankfurt Main, Germany
Int J Antimicrob Agents 17:203-8. 2001..burgdorferi complex. The excellent in vitro effectiveness of acylamino-penicillin derivatives and their suitability for the therapy of Lyme disease is emphasised...
- Single or double mutational alterations of gyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coliR Bachoual
, Centre Hospitalier Universitaire Henri Mondor, , France
Microb Drug Resist 7:257-61. 2001..In contrast with the results obtained with clinical isolates, a variety of gyrA mutations were obtained in vitro...
- FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiaeJ Heitman
Department of Biochemistry, University of Basel, Switzerland
Proc Natl Acad Sci U S A 88:1948-52. 1991..However, FKBP is only one of at least two targets because strains lacking FKBP are only partially resistant to FK 506...
- A small protein that mediates the activation of a two-component system by another two-component systemL F Kox
Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110 1093, USA
EMBO J 19:1861-72. 2000..A pmrD mutant is sensitive to polymyxin if grown in low magnesium, but resistant if grown in high iron. The PmrD protein controls the activity of the PmrA-PmrB system at a post-transcriptional level...
- Need for annual surveillance of antimicrobial resistance in Streptococcus pneumoniae in the United States: 2-year longitudinal analysisD F Sahm
MRL, Herndon, Virginia 20171 4603, USA
Antimicrob Agents Chemother 45:1037-42. 2001..This longitudinal surveillance study of resistance in S. pneumoniae revealed that significant changes do occur in just a single year and supports the need for surveillance at least on an annual basis, if not continuously...
- Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolonesL Ferrero
Departement des Biotechnologies, Rhone Poulenc Rorer S A, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
Mol Microbiol 13:641-53. 1994..coli GyrA, is substituted to Phe or Tyr in both high- and low-quinolone-resistant isolates. We propose that DNA topoisomerase IV is a primary target of fluoroquinolones in S. aureus...
- Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenC K Stover
PathoGenesis Corporation, Seattle, Washington 98119, USA
Nature 406:959-64. 2000..We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances...
- Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patientsM H Kollef
Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, St Louis, MO 63110, USA
Clin Infect Dis 31:S131-8. 2000..Further study evaluating the use of antibiotic practice guidelines and strategies to reduce inadequate treatment is necessary to determine their impact on patient outcomes...
- Antibiotic combination therapy in patients with chronic, treatment-resistant pouchitisP Gionchetti
Dipartimento di Medicina Interna e Gastroenterologia, Italy
Aliment Pharmacol Ther 13:713-8. 1999..Pouchitis is the major long-term complication after ileal pouch-anal anastomosis for ulcerative colitis. About 15% of patients have a chronic, treatment-resistant disease...
- The spread of multiply resistant Streptococcus pneumoniae at a day care center in OhioM R Reichler
Respiratory Diseases Branch, Centers for Disease Control, Atlanta, Georgia 30333
J Infect Dis 166:1346-53. 1992..001). Strategies to limit the spread of highly resistant pneumococcal strains should include encouraging judicious use of antimicrobic agents and reevaluating indications for prophylactic use of antimicrobic agents...
- Emergence of the M phenotype of erythromycin-resistant pneumococci in South AfricaC A Widdowson
South African Institute for Medical Research, Johannesburg, South Africa
Emerg Infect Dis 4:277-81. 1998..These data suggest that, although macrolide resistance in pneumococci remains low in the public sector, the mefE gene is rapidly emerging in South Africa...
- Tracking drug-resistant Streptococcus pneumoniae in Oregon: an alternative surveillance methodA E Chin
Oregon Health Division, Portland, Oregon, USA
Emerg Infect Dis 5:688-93. 1999..Although yielding fewer data than active surveillance, antibiograms provided accurate, community-specific drug-resistant S. pneumoniae data in Oregon...
- Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenesJ Clancy
Central Research Division, Pfizer Incorporated, Groton, Connecticut 06340, USA
Mol Microbiol 22:867-79. 1996..The gene appears to be widely distributed in S. pyogenes strains, as demonstrated by primer-specific synthesis using the polymerase chain reaction...
- Efficient targeted mutagenesis in Borrelia burgdorferiJ L Bono
Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana 59840, USA
J Bacteriol 182:2445-52. 2000..The kanamycin resistance marker allows efficient direct selection of mutants in B. burgdorferi and hence is a significant improvement in the ability to construct isogenic mutant strains in this pathogen...
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisA Banerjee
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
Science 263:227-30. 1994..These results suggest that InhA is likely a primary target of action for INH and ETH...
- The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosisY Zhang
MRC Tuberculosis and Related Infections Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Nature 358:591-3. 1992..Deletion of katG from the chromosome was associated with INH resistance in two patient isolates of M. tuberculosis...
- Naturally occurring Staphylococcus epidermidis plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a deleted attenuatorB C Lampson
J Bacteriol 166:479-83. 1986..Constitutive expression of ermM is due to the deletion of 107 base pairs relative to ermC; the deletion removes critical sequences for attenuation, resulting in constitutive methylase expression...
- Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1EA Rojas
Department of Biochemistry and Molecular and Cell Biology of Plants, Estacion Experimental del Zaidin, CSIC, E 18008 Granada, Spain
J Bacteriol 183:3967-73. 2001..The triple mutant was hypersensitive to toluene, as shown by its inability to grow with toluene supplied via the vapor phase...
- A signal transduction system that responds to extracellular ironM M Wösten
Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cell 103:113-25. 2000..A pmrA mutant was hypersensitive to killing by iron but displayed wild-type resistance to a variety of oxidants, suggesting PmrA/PmrB controls a novel pathway mediating the avoidance of iron toxicity...
- A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenesH Seppala
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland
Antimicrob Agents Chemother 42:257-62. 1998..5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes...
- Standard short-course chemotherapy for drug-resistant tuberculosis: treatment outcomes in 6 countriesM A Espinal
World Health Organization, Communicable Diseases Programme, Ave Appia 20, 1211 Geneva 27, Switzerland
JAMA 283:2537-45. 2000....
- The frost gene of Neurospora crassa is a homolog of yeast cdc1 and affects hyphal branching via manganese homeostasisT Sone
Department of Botany, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, V6T 1Z4, Canada
Fungal Genet Biol 28:227-37. 1999..The fr mutant was also sensitive to calcineurin inhibitors. These results suggest that fr is involved in Mn(2+) homeostasis and point to a role for Mn(2+) in Neurospora branching...
- Epidemiology of emerging pneumococcal drug resistance: implications for treatment and preventionJ C Butler
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
Vaccine 16:1693-7. 1998..However, the vaccine is underutilized, and a substantial reduction in the morbidity and mortality associated with invasive pneumococcal infections is unlikely until the vaccine is used more widely among persons at risk for disease...
- Detection of rifampicin-resistance mutations in Mycobacterium tuberculosisA Telenti
Institute for Medical Microbiology, University of Berne, Switzerland
Lancet 341:647-50. 1993..These findings provide the basis for rapid detection of rifampicin resistance, a marker of multidrug-resistant tuberculosis...
- Thermoanaerobacter mathranii sp. nov., an ethanol-producing, extremely thermophilic anaerobic bacterium from a hot spring in IcelandL Larsen
Department of Environmental Science and Engineering, Technical University of Denmark, Bldg 115, DK 2800 Lyngby, Denmark
Arch Microbiol 168:114-9. 1997..Genotypic and phenotypic differences between strain A3 and other related species indicate that strain A3 can be assigned to a new species, and the name Thermoanaerobacter mathranii is proposed...
- Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniaeH Fukuda
Central Research Laboratories, Kyorin Pharmaceutical Co, Ltd, 2399 1, Mitarai, Nogi, Shimotsuga, Tochigi 329 0114, Japan
Antimicrob Agents Chemother 45:1649-53. 2001....
- Antibiotic resistance in the intensive care unitM H Kollef
Campus Box 8052, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Ann Intern Med 134:298-314. 2001..Careful, focused attention to this problem at the local ICU level, using a multidisciplinary approach, will have the greatest likelihood of limiting the development and dissemination of antibiotic-resistant infections...
- Regional trends in antimicrobial resistance among clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States: results from the TRUST Surveillance Program, 1999-2000Clyde Thornsberry
Focus Technologies Inc, Nashville, TN, USA answers com
Clin Infect Dis 34:S4-S16. 2002..6%) and M. catarrhalis (86.2%-96.8%) also varied by region. Notable variation in regional antimicrobial resistance rates (S. pneumoniae) and beta-lactamase production (H. influenzae, M. catarrhalis) exists throughout the United States...
- Treatment outcome of new culture positive pulmonary tuberculosis in NorwayMohamed Guled Farah
Norwegian Institute of Public Health, Oslo, Norway
BMC Public Health 5:14. 2005..The aims of this study were to evaluate the treatment outcome for new cases of culture positive pulmonary TB registered in Norway during the period 1996-2002 and to identify factors associated with non-successful treatment...
- Fluoroquinolone-resistant Campylobacter isolates from conventional and antibiotic-free chicken productsLance B Price
Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe Street, Suite W6114, Baltimore, MD 21205, USA
Environ Health Perspect 113:557-60. 2005..These results suggest that FQ resistance may persist in the commercial poultry environment in the absence of FQ-selective pressure and that these strains contaminate a larger proportion of foods than reported previously...
- Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland, and NorwayF M Aarestrup
Danish Veterinary Laboratory, Copenhagen
Microb Drug Resist 6:63-70. 2000..This study indicates that the use of antimicrobial agents for growth promotion in Denmark, Finland, and Norway have selected for resistance to most of these drugs among E. faecium in food animals...
- Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coliH I Zgurskaya
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3206, USA
J Bacteriol 182:4264-7. 2000..We show that AcrA protein forms oligomers, most probably trimers. In this oligomeric form, AcrA interacts specifically with AcrB transporter independently of substrate and TolC...
- A protease-resistant catalase, KatA, released upon cell lysis during stationary phase is essential for aerobic survival of a Pseudomonas aeruginosa oxyR mutant at low cell densitiesD J Hassett
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
J Bacteriol 182:4557-63. 2000..Taken together, our results indicate that inactivation of OxyR renders P. aeruginosa exquisitely sensitive to both H(2)O(2) and aminoglycosides, which are clinically and environmentally important antimicrobials...
- Pentapeptide repeat proteinsMatthew W Vetting
Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Biochemistry 45:1-10. 2006..MfpA binds to DNA gyrase and inhibits its activity. The rod-shaped, dimeric protein exhibits remarkable similarity in size, shape, and electrostatics to DNA...
- The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenesElizabeth Pradel
INSERM CJF9606 EA2197, IFR48, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Antimicrob Agents Chemother 46:2640-3. 2002..Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant...
- Contribution of exogenous genetic elements to the group A Streptococcus metagenomeStephen B Beres
Center for Molecular and Translational Human Infectious Diseases Research, Methodist Hospital Research Institute, Houston, Texas, United States of America
PLoS ONE 2:e800. 2007..The data provide new information about the GAS metagenome and will assist studies of pathogenesis, antimicrobial resistance, and population genomics...
- Tensions in antibiotic prescribing: pitting social concerns against the interests of individual patientsJoshua P Metlay
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
J Gen Intern Med 17:87-94. 2002..However, optimal use from the perspective of the community (reserving newer agents for future use) is not always consistent with optimal use from the perspective of the individual patient (prescribing newer, broader agents)...
- Temperature-regulated efflux pump/potassium antiporter system mediates resistance to cationic antimicrobial peptides in YersiniaJ A Bengoechea
Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
Mol Microbiol 37:67-80. 2000..It is proposed that the RosA/RosB system protects the bacteria by both acidifying the cytoplasm to prevent the CAMPs action and pumping the CAMPs out of the cell...
- Mutations in the ss subunit of the Bacillus subtilis RNA polymerase that confer both rifampicin resistance and hypersensitivity to NusGC J Ingham
School of Biological Sciences, University Park, Nottingham University, Nottingham NG7 2RD, UK
Microbiology 146:3041-9. 2000..Autoregulation required sequences within the 5' coding sequence of the nusG gene or immediately upstream. This is the first evidence from any bacterium that Rif(r) RNA polymerases can display altered transcription regulation by NusG...
- A model of a transmembrane drug-efflux pump from Gram-negative bacteriaJuan Fernandez-Recio
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
FEBS Lett 578:5-9. 2004..coli, and for the AcrA homologue MexA from Pseudomonas aeruginosa. Based on homology modelling and molecular docking, we show how AcrA, AcrB and TolC might assemble to form a tripartite pump, and how allostery may occur during transport...
- Protein export and drug efflux through bacterial channel-tunnelsC Andersen
Cambridge University Department of Pathology, Tennis Court Road, CB2 1QP, Cambridge, UK
Curr Opin Cell Biol 13:412-6. 2001..TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane...
- A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environmentAjit K Sarmah
Landcare Research New Zealand Limited, Private Bag 3127, Hamilton, New Zealand
Chemosphere 65:725-59. 2006..The final section highlights some unresolved questions and presents a way forward on issues requiring urgent attention...
- The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of AmericaBrad Spellberg
Division of Infectious Diseases, Harbor University of California Los Angeles UCLA Medical Center, Torrance, CA 90502, USA
Clin Infect Dis 46:155-64. 2008..If we are to address the antimicrobial resistance crisis, a concerted, grassroots effort led by the medical community will be required...
- Biofilm induced tolerance towards antimicrobial peptidesAnders Folkesson
Infection Microbiology Group, BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
PLoS ONE 3:e1891. 2008....
- Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpAC Montero
, , Instituto de Investigaciones Cientificas (IVIC, Caracas 1020A, Venezuela
Antimicrob Agents Chemother 45:3387-92. 2001..smegmatis mutant strain lacking an intact mfpA gene than for the WT strain, suggesting that, by some unknown mechanism, the gene product plays a role in determining the innate level of FQ(R) in M. smegmatis...
- Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constinsB Hochhut
Division of Geographic Medicine/Infectious Diseases, New England Medical Center, Tufts University School of Medicine, and Howard Hughes Medical Institute, Boston, Massachusetts 02111, USA
Antimicrob Agents Chemother 45:2991-3000. 2001..These studies indicate that there is considerable flux in the antibiotic resistance genes found in the SXT family of constins and point to a model for the evolution of these related mobile elements...
- The Rcs phosphorelay is a cell envelope stress response activated by peptidoglycan stress and contributes to intrinsic antibiotic resistanceMary E Laubacher
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
J Bacteriol 190:2065-74. 2008..We propose that the Rcs pathway responds to peptidoglycan damage and contributes to the intrinsic resistance of E. coli to beta-lactam antibiotics...
- Transient intestinal carriage after ingestion of antibiotic-resistant Enterococcus faecium from chicken and porkT L Sørensen
Department of Microbiological Research and Development, Statens Serum Institut, Copenhagen, Denmark
N Engl J Med 345:1161-6. 2001..Antibiotic-resistant enterococci are often present in retail meats, but it is unclear whether the ingestion of these contaminants leads to sustained intestinal carriage...
- The impact of antimicrobial resistance on health and economic outcomesSara E Cosgrove
Division of Infectious Disease, Johns Hopkins Hospital, Baltimore, MD, USA
Clin Infect Dis 36:1433-7. 2003....
- Treatment of isoniazid-resistant tuberculosis in southeastern TexasP Escalante
Sections of Pulmonary and Critical Care, Institute for the Study of Human Bacterial Pathogenesis, Baylor College of Medicine, Houston, TX, USA
Chest 119:1730-6. 2001..Isoniazid-resistant tuberculosis (INHr-TB) can be treated successfully with several treatment regimens. However, the optimal regimen and duration are unclear...
- Distribution of mef(A) in gram-positive bacteria from healthy Portuguese childrenVicki A Luna
Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Antimicrob Agents Chemother 46:2513-7. 2002..isolate, and an Enterococcus sp. isolate had their mef(A) genes completely sequenced and showed 100% identity at the DNA and amino acid levels with the mef(A) gene from S. pneumoniae...
- Veterinary drug usage and antimicrobial resistance in bacteria of animal originFrank M Aarestrup
Danish Institute for Food and Veterinary Research, Copenhagen V, Denmark
Basic Clin Pharmacol Toxicol 96:271-81. 2005..Programmes monitoring the occurrence and development of resistance and consumption of antimicrobial agents are strongly desirable, as is research into the most appropriate ways to use antimicrobial agents in veterinary medicine...
- A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinoseSteven D Breazeale
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:14154-67. 2005..Because the L-Ara4N unit attached to lipid A is not derivatized with a formyl group, we postulate the existence of a deformylase, acting later in the pathway...
- Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in childrenArthur L Frank
Department of Pediatrics, College of Medicine, University of Illinois at Chicago, USA
Pediatr Infect Dis J 21:530-4. 2002..There is a risk for the appearance of resistance during clindamycin therapy of erythromycin-resistant MRSA infections because of the linked resistance mechanisms...
- Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinantsJ W Beaber
Division of Geographic Medicine Infectious Diseases, New England Medical Center, NEMC 041, 750 Washington St, Boston, Massachusetts 02111, USA
Cell Mol Life Sci 59:2065-70. 2002..This backbone represents a scaffold for the mobilization of genetic material between a wide range of gram-negative bacteria, allowing for rapid adaptation to changing environments...
- Mechanisms of resistance to antibioticsGerard D Wright
Department of Biochemistry, McMaster University, 1200 Main St W, Hamilton, Ontario L8N 3Z5, Canada
Curr Opin Chem Biol 7:563-9. 2003....
- Overcoming antimicrobial resistance: profile of a new ketolide antibacterial, telithromycinR Leclercq
CHU de Caen, Service de Microbiologie, Avenue Cote de Nacre, 14033 Caen Cedex, France
J Antimicrob Chemother 48:9-23. 2001..Telithromycin therefore represents an important addition to the therapeutic armamentarium in an era of increasing antimicrobial resistance, with an expected low likelihood of the development of resistance in clinical use...
- Horizontal transfer of a multi-drug resistance plasmid between coliform bacteria of human and bovine origin in a farm environmentH Oppegaard
Department of Pharmacology, Microbiology, and Food Hygiene, The Norwegian School of Veterinary Science, N 0033 Oslo, Norway
Appl Environ Microbiol 67:3732-4. 2001..Isolates from both cattle and humans harbored an R plasmid of 65 kb (pTMS1) that may have been transferred between them due to selective antibiotic pressure in the farm environment...
- The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in childrenM J Trepka
Epidemic Intelligence Service, State Branch, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Pediatrics 107:E6. 2001..Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria...
- ENZYMOLOGY OF ANTIBIOTIC RESISTANCERichard Armstrong; Fiscal Year: 2009..These investigations will establish the bases for the design of new drugs to counter resistance to fosfomycin that is encoded in the genomes of select human pathogens. ..
- Broad-Spectrum Antimicrobials Targeting the D-Alanine PathwayKAREN G ANTHONY; Fiscal Year: 2013..Accomplishing this goal would enhance our national preparedness for natural, accidental and intentional exposure to several pathogens, and help address emerging microbial drug resistance.
- TRAINING IN GEOGRAPHIC MEDICINE AND INFECTIOUS DISEASESJAMES WALTER KAZURA; Fiscal Year: 2013....
- Advanced Infection Control methods for Antimicrobial Drug Resistance and PathogenChristopher N Larsen; Fiscal Year: 2010..This research will increase our understanding of microbial drug resistance, enable the tracking of new drug resistant organisms, and provide a measurement and surveillance utility ..
- Pan Genomic Discovery of Genes Toxic to BacteriaEdward M Rubin; Fiscal Year: 2012..This approach will be used to detect and develop new antimicrobial agents as well as study a new class of RNA molecules that are toxic to bacteria. ..
- Genetic Variation and Evolution of Artemisinin ResistanceDyann F Wirth; Fiscal Year: 2013..project will expand our fundamental understanding of both the genetic variation of malaria and microbial drug resistance among malaria parasites by confirming artemisinin resistance phenotypes, identify the gene (or genes) ..
- Pneumococcal transmission in urban environmentsJoshua Metlay; Fiscal Year: 2009....
- Molecular Basis of Microbial PathogenesisRandall Holmes; Fiscal Year: 2007..b>Microbial drug resistance, emerging infections, use of microbes as bioterrorism weapons, and acquired immunodeficiency syndrome (..
- SYNTHETIC ANTIBACTERIAL PEPTIDESGennadi Glinsky; Fiscal Year: 2000..It is further proposed that Phase II methodology will address the selected analog's ability to treat bacterial infections in vivo. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Metabolic Drug Targeting in Haemophilus influenzeCHRISTOPHE SCHILLING; Fiscal Year: 2004..influenzae infections; 5) and enhanced validation of existing targets in H. influenzae. ..
- Study design importance in analyzing emerging pathogensAnthony Harris; Fiscal Year: 2005..The second aim will be done by combining epidemiological relatedness and molecular relatedness through pulse-field gel electrophoresis of ESBL cultures to quantify the importance of patient to patient transmission. ..
- Epidemiologic Methods: Resistant Nosocomial InfectionsMarc Lipsitch; Fiscal Year: 2004..This will in turn lead to better practices to reduce the incidence of ARNI. ..
- New Nosocomial Interventions to Decrease Antimicrobial Resistance TransmissionAnthony Harris; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Hepatitis C Virus Induced IL-8 & Inhibition of InterferonSTEPHEN POLYAK; Fiscal Year: 2007..Moreover, IL-8 or its receptors may prove to be suitable targets for therapeutic intervention in chronic hepatitis C. ..
- Impact of Hand Hygiene Guideline on Infections and CostsElaine Larson; Fiscal Year: 2005..abstract_text> ..
- HOME HYGIENE INTERVENTIONElaine Larson; Fiscal Year: 2002..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
- HUMAN RETROVIRUS-5 AND ARTHRITISRobin Patel; Fiscal Year: 2002..Identification of a specific infectious agent associated with these arthritides would potentially allo for the development of preventive strategies such as vaccination and novel therapeutic approaches. ..
- Antivirals directed to novel targets in the virus-coded proteinase of adenovirusWALTER MANGEL; Fiscal Year: 2007..abstract_text> ..
- Detection of Biofilm Bacteria using GloBacRobin Patel; Fiscal Year: 2008..The goal of the proposed studies is to develop a rapid test for detection of bacteria on artificial joints that can be used in the operating room to diagnose infected artificial joints. [unreadable] [unreadable] [unreadable]..
- 9th Annual International Mtg on HIV Dynamics & EvolutionDouglas Richman; Fiscal Year: 2002..Participants in the 9th Meeting will include leading figures in virology, biomathematics, and evolution, as well as junior workers actively involved in research in these areas. ..
- Interdisciplinary Research:Antimicrobial Resistance(RMI)Elaine Larson; Fiscal Year: 2006..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
- QUINOLONE RESISTANCE MECHANISMS IN STAPHYLOCOCCUS AUREUSDavid Hooper; Fiscal Year: 2007..abstract_text> ..
- Enhancement of antimicrobics by electrical currentRobin Patel; Fiscal Year: 2007..This novel but simple resistance reversing strategy may generalize to a wide variety of antimicrobics and microorganisms and a wide variety of biofilm-associated human infections. [unreadable] [unreadable] [unreadable] [unreadable]..
- ANTIVIRAL RESISTANCE IN AIDSDouglas Richman; Fiscal Year: 2004....
- Novel inhibitors of M. tuberculosis RNA PolymeraseAnthony Lynch; Fiscal Year: 2003..Phase II studies would thereafter be addressed toward systematic optimization of the series as an antitubercular agent. ..
- The impact of early antiretroviral therapy on HIV persistence and inflammationSTEVEN GRANT DEEKS; Fiscal Year: 2010..Our work may also provide important insights in the role of chronic inflammation in driving viral persistence, and hence may lead to the development of novel interventions. ..
- Treatment Intensification for Drug-Resistant HIVSteven Deeks; Fiscal Year: 2004..Funding for the pilot clinical trial has been obtained from other sources; funding is requested in this proposal only for costs associated with the measurements of immunologic response to drug-resistant HIV-1. ..
- Immunologic Control of Drug-resistant HIV-1Steven Deeks; Fiscal Year: 2005..Finally, since we will estimate the relative in vivo thresholds for HIV-mediated immunogenicity and pathogenicity, these studies may also have implications for vaccine development. ..
- Hepatitis C Virus Proteins and EthanolSTEPHEN POLYAK; Fiscal Year: 2004..abstract_text> ..
- Role of Genomic Imprinting in Developmental Neurotoxici*Ellen Silbergeld; Fiscal Year: 2003..2. To utilize high throughput methods to examine patterns of DNA methylation in candidate genes in sperm and zygote in order to detect the presence of male-mediated effects on imprinted genes involved in early development. ..
- DNA GYRASE AND QUINOLONE RESISTANCE IN TUBERCULOSISKarl Drlica; Fiscal Year: 2007..abstract_text> ..
- Calcineurin and Aspergillus fumigatus PathogenesisWILLIAM STEINBACH; Fiscal Year: 2008..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
- Staff Hand Hygiene and Nosocomial Infections in NeonatesElaine Larson; Fiscal Year: 2003....
- Stopping URIs and FLU in the Family: the Stuffy TrialElaine Larson; Fiscal Year: 2008....
- THE ROLE OF MYCOBACTERIA IN CROHN'S DISEASEDavid Graham; Fiscal Year: 2005..The results of this study should either confirm or refute the proposed etiologic association of M. paratuberculosis and Crohn's disease as well as the identification of patients with Crohn's disease and M. paratuberculosis. ..
- REVERSE TRANSCRIPTASE AND OTHER HIV MOLECULAR STRUCTURESThomas Steitz; Fiscal Year: 2002..Crystallographic studies of both full length HIV integrase and the homologous transposase, TN552, complexed with suitable DNA substrates are aimed to produce mechanistic insights. ..
- Device use in Nursing Homes: Reducing Risk of InfectionLona Mody; Fiscal Year: 2007..abstract_text> ..
- Genetic Susceptibility to Mercury-Induced Immune Dysfunction in Autism & ASDEllen Silbergeld; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- 2008 Bacterial Cell Surfaces Gordon Research ConferenceANNE DELCOUR; Fiscal Year: 2008..Success in these research endeavors is enhanced by the exchange of information and ideas promoted by the Bacterial Cell Surfaces Gordon Conference. [unreadable] [unreadable] [unreadable]..
- Infection, Inflammation and PreeclampsiaCatherine Haggerty; Fiscal Year: 2009..Finally, cytokine and CRP testing may prove to be effective tools for identifying women at risk for developing preeclampsia. ..
- Clinical Significance of HIV Replication FitnessLisa Demeter; Fiscal Year: 2008..If these studies are successful, they could identify tests that could help predict clinical outcomes for HIV-infected patients. ..
- DEVELOPMENT OF STAPHYLOCOCCALCIDAL HUMAN PEPTIDESWilliam Shafer; Fiscal Year: 2008..This information should help in the development of new effective peptide-based drugs that could be used in the future to combat staphylococcal diseases caused by antibiotic-resistant strains. ..
- Novel Targets for Treatment of Pseudomonas aeruginosaPhilip Lister; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Sexually Transmitted Infections & Antimicrobial PeptidesWilliam Shafer; Fiscal Year: 2009..abstract_text> ..
- Hospital-Acquired Infections in the ElderlyKeith Kaye; Fiscal Year: 2008..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
- HIV Outcomes Research and Training in UgandaDavid Bangsberg; Fiscal Year: 2008..abstract_text> ..
- METALLO BETA LACTAMASE FROM X MALTOPHILIAMichael Crowder; Fiscal Year: 2002....
- NATURAL SUBSTRATES AND INHIBITORS OF MICROBIAL MDR PUMPSKim Lewis; Fiscal Year: 2002..MDR inhibitors will potentiate the action of conventional antibiotics, aiding eradication of multidrug resistant human pathogens. ..
- DISEASE ON NEW HOSTS: MICROBOTRYUM AS A MODEL SYSTEMJanis Antonovics; Fiscal Year: 2002..Determine the role of genetic factors in the transmission of a pathogen to a new host, c. Determine the role of pathogen specialization in persistence on new hosts. ..
- Safety and Efficacy of C31G for Ocular InfectionsRichard Bax; Fiscal Year: 2003..Upon achievement of these specific aims, the lead formulation will be advanced through preclinical FDA required studies via a Phase II SBIR. ..
- GENETIC RECOMBINATION IN MYCOPLASMASKevin Dybvig; Fiscal Year: 2004..In aim 2, mutants with defects in putative DNA recombinases and V-I protein production will be examined to study the mechanisms of gene rearrangements and phenotypic switching. ..
- Phase II SBIR: WHI-07: A Novel Dual-Function MicrobicideOSMOND D CRUZ; Fiscal Year: 2005....
- Hemin Receptor Gene Family of Bartonella quintanaMICHAEL MINNICK; Fiscal Year: 2006..abstract_text> ..
- X-ray Structures of Small MDR Efflux PumpsGeoffrey Chang; Fiscal Year: 2006..3. X-ray structure determination and refinement of SMR transporters.4. Structural studies of SMR transporters concerning substrate translocation.5. Structural studies of SMR transporters concerning substrate recognition. ..
- EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINESStuart Levy; Fiscal Year: 2006..Such understanding will also enhance[unreadable] efforts to reverse efflux of other antibiotics and drugs used to treat infectious diseases, including[unreadable] bacteria, fungi and parasites, and cancer. ..
- Non-nucleoside Reverse Transcriptive HypersensitivityNancy Shulman; Fiscal Year: 2006....
- Infection Risk of Urinary Collection StrategiesSanjay Saint; Fiscal Year: 2006..Since approximately 40% of elderly Americans will enter a nursing home at some point, identification of those at risk of infection could have considerable health, quality of life, and economic consequences. ..
- Role of fitness in HIV protease inhibitor resistanceRonald Swanstrom; Fiscal Year: 2006..Finally, we will develop SIVsm as a resistance/fitness model to prepare for future studies that will allow a formal test of the contribution of attenuated replication capacity to reduced pathogenicity. ..
- Mycoplasma Genitalium and Pelvic Inflammatory DiseaseCatherine Haggerty; Fiscal Year: 2007..Exploring the role of M. genitalium in PID is imperative to optimize diagnosis and treatment and prevent reproductive morbidity among women with nongonococcal/nonchlamydial PID. ..
- A randomized trial of influenza vaccination of Hutterite childrenMark Loeb; Fiscal Year: 2006..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..
- Bioactive Compounds from Acylnitroso CycloadductsMarvin Miller; Fiscal Year: 2006..abstract_text> ..
- Derivatization/Functionalization of Natural Product(RMI)Marvin Miller; Fiscal Year: 2007..3. Broadly test the scaffold and derived libraries of novel compounds using the extensive set of assays in place at the Hans-Knoll Institute for Natural Products Research (HKI). ..
- Clinical Approaches to Ileal Pouch DysfunctionBo Shen; Fiscal Year: 2005..The AIMS of study are to 1) investigate visceral hypersensitivity using barostat examination of the pouch; 2) conduct a randomized, placebo-controlled clinical trial evaluating the use of amitriptyline in IPS. ..
- REDUCING ANTIMICROBIAL RESISTANCE: A RANDOMIZED TRIALJonathan Finkelstein; Fiscal Year: 2003..Cost-effectiveness analysis will estimate the financial and other costs per resistant infection avoided. ..
- Improving Antibiotic Use in Acute Care SettingsRalph Gonzales; Fiscal Year: 2006..Specific Aim 2: To evaluate the impact of a rapid diagnostic test for c-reactive protein on antibiotic use for adults with acute cough illness when added to a multidimensional intervention. ..
- Minimizing Antibiotic Resistance in Colorado (MARC)Ralph Gonzales; Fiscal Year: 2004..pneumoniae infections in and outside the intervention communities. Specific Aim IIIC: Conduct a net-cost analysis of the different levels of community education. ..