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Avoiding DEET through insect gustatory receptorsYoungseok Lee
Department of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 67:555-61. 2010..DEET stimulated action potentials in GRNs that respond to aversive compounds, and this response was lost in the Gr32a, Gr33a, and Gr66a ..
Neurophysiological investigation of the basis of the fMRI signalN K Logothetis
Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
Nature 412:150-7. 2001..These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output...- Modulation of oscillatory neuronal synchronization by selective visual attentionP Fries
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
Science 291:1560-3. 2001..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex... - Synaptic activity and the construction of cortical circuitsL C Katz
Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Science 274:1133-8. 1996..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life... - Millisecond-timescale, genetically targeted optical control of neural activityEdward S Boyden
Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
Nat Neurosci 8:1263-8. 2005..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers... - Weak pairwise correlations imply strongly correlated network states in a neural populationElad Schneidman
Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA
Nature 440:1007-12. 2006..As a first test for the generality of these ideas, we show that similar results are obtained from networks of cultured cortical neurons... - Microstructure of a spatial map in the entorhinal cortexTorkel Hafting
Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Nature 436:801-6. 2005..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment... 
Spiking activity propagation in neuronal networks: reconciling different perspectives on neural codingArvind Kumar
Bernstein Center Freiburg and Faculty of Biology, University of Freiburg, Hansastrasse 9A, 79104, Freiburg, Germany
Nat Rev Neurosci 11:615-27. 2010..Here, we review the dichotomy of asynchronous and synchronous propagation in FFNs, propose their integration into a single extended conceptual framework and suggest experimental strategies to test our hypothesis...- Spatio-temporal correlations and visual signalling in a complete neuronal populationJonathan W Pillow
Gatsby Computational Neuroscience Unit, UCL, 17 Queen Square, London WC1N 3AR, UK
Nature 454:995-9. 2008..This model-based approach reveals the role of correlated activity in the retinal coding of visual stimuli, and provides a general framework for understanding the importance of correlated activity in populations of neurons... - Modulation of neuronal interactions through neuronal synchronizationThilo Womelsdorf
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands
Science 316:1609-12. 2007..These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions... - Multimodal fast optical interrogation of neural circuitryFeng Zhang
Department of Bioengineering, Stanford University, Stanford, California 94305, USA
Nature 446:633-9. 2007..NpHR allows either knockout of single action potentials, or sustained blockade of spiking... - Dynamics of sparsely connected networks of excitatory and inhibitory spiking neuronsN Brunel
LPS, Ecole Normale Superieure, Paris, France
J Comput Neurosci 8:183-208. 2000..In the slow oscillatory state, the network frequency depends mostly on the membrane time constant. Finite size effects in the asynchronous state are also discussed... - Decorrelated neuronal firing in cortical microcircuitsAlexander S Ecker
Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
Science 327:584-7. 2010..Our findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated... - The gamma cyclePascal Fries
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
Trends Neurosci 30:309-16. 2007..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)... - The asynchronous state in cortical circuitsAlfonso Renart
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
Science 327:587-90. 2010..Our results suggest a reexamination of the sources underlying observed correlations and their functional consequences for information processing... - What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balanceNicolas Brunel
Centre National de la Recherche Scientifique Neurophysique et Physiologie du Système Moteur Université Paris René Descartes, 75270 Paris Cedex 06, France
J Neurophysiol 90:415-30. 2003..Faster excitation than inhibition, or a higher excitation/inhibition ratio, favors the feedback loop and a much slower oscillation (typically in the gamma range)... - Neural correlations, population coding and computationBruno B Averbeck
Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
Nat Rev Neurosci 7:358-66. 2006..Here, we review studies that address the interaction between neuronal noise and population codes, and discuss their implications for population coding in general... - High-frequency, long-range coupling between prefrontal and visual cortex during attentionGeorgia G Gregoriou
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 324:1207-10. 2009.... - Gain modulation from background synaptic inputFrances S Chance
Center for Neural Science, New York University, New York, NY 10003, USA
Neuron 35:773-82. 2002..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive... - Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principleMatthew E Larkum
Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
Science 325:756-60. 2009.... - Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkeyM N Shadlen
Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
J Neurophysiol 86:1916-36. 2001..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement... - Real-time computing without stable states: a new framework for neural computation based on perturbationsWolfgang Maass
Institute for Theoretical Computer Science, Technische Universitat Graz, A 8010 Graz, Austria
Neural Comput 14:2531-60. 2002..Our approach provides new perspectives for the interpretation of neural coding, the design of experiments and data analysis in neurophysiology, and the solution of problems in robotics and neurotechnology... - Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibitionF Pouille
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Science 293:1159-63. 2001..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows... - Multiple neural spike train data analysis: state-of-the-art and future challengesEmery N Brown
Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
Nat Neurosci 7:456-61. 2004..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research... - How connectivity, background activity, and synaptic properties shape the cross-correlation between spike trainsSrdjan Ostojic
Institut des Systemes Complexes Paris Ile de France and Laboratoire de Physique Statistique, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Universite Paris Diderot, Ecole Normale Superieure, Paris, France
J Neurosci 29:10234-53. 2009..In particular, we show that the postsynaptic neuron spiking regularity has a pronounced influence on CCF amplitude. This suggests an efficient and flexible mechanism for modulating functional interactions... - Spike synchronization and rate modulation differentially involved in motor cortical functionA Riehle
Center for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
Science 278:1950-3. 1997..of a delayed-pointing task exhibited context-dependent, rapid changes in the patterns of coincident action potentials. Accurate spike synchronization occurred in relation to external events (stimuli, movements) and was .. - Extracting information from neuronal populations: information theory and decoding approachesRodrigo Quian Quiroga
Department of Engineering, University of Leicester, Leicester, LE1 7RH, UK
Nat Rev Neurosci 10:173-85. 2009..Such population analysis can give us more information about how neurons encode stimulus features than traditional single-cell studies... - The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortexSandrine Lefort
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
Neuron 61:301-16. 2009..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution... - An ultra-sparse code underlies the generation of neural sequences in a songbirdRichard H R Hahnloser
Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
Nature 419:65-70. 2002.... - Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cellsGilad Silberberg
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
Neuron 53:735-46. 2007..responses were evoked in layer 5 PCs following stimulation of individual neighboring PCs with trains of action potentials. The probability for inhibition between PCs was more than twice that of direct excitation, and inhibitory .. - Spike timing-dependent plasticity of neural circuitsYang Dan
Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
Neuron 44:23-30. 2004..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule... - Correlation between neural spike trains increases with firing rateJaime de la Rocha
Center for Neural Science, New York University, New York 10003, USA
Nature 448:802-6. 2007..thalamus, and several cortical regions show temporal correlation between the discharge times of their action potentials (spike trains)... - Spatial representation in the entorhinal cortexMarianne Fyhn
Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Science 305:1258-64. 2004.... - Turning on and off recurrent balanced cortical activityYousheng Shu
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Nature 423:288-93. 2003..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex... - Adaptive exponential integrate-and-fire model as an effective description of neuronal activityRomain Brette
Dept d Informatique, Equipe Odyssée, Ecole Normale Superieure, 45 rue d Ulm, 75230 Paris Cedex 05, France
J Neurophysiol 94:3637-42. 2005..These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro... - Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexGiorgio A Ascoli
Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
Nat Rev Neurosci 9:557-68. 2008..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project... - Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndromeClaire A Martin
Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, United Kingdom
J Cardiovasc Electrophysiol 21:1153-9. 2010..We compared activation latencies and spatial differences in action potential recovery between different ventricular regions in a murine Scn5a+/- BrS model, and investigated the effect of flecainide and quinidine upon these... - Measuring and interpreting neuronal correlationsMarlene R Cohen
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
Nat Neurosci 14:811-9. 2011..Given these complicating factors, we offer guidelines for interpreting correlation data and a discussion of how best to evaluate the effect of correlations on cortical processing... - Nonlinear multivariate analysis of neurophysiological signalsErnesto Pereda
Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, Avda Astrofísico Fco Sánchez s n, 38205 La Laguna, Tenerife, Spain
Prog Neurobiol 77:1-37. 2005..Finally, we illustrate the use of multivariate surrogate data test for the assessment of the strength (strong or weak) and the type (linear or nonlinear) of interdependence between neurophysiological signals... - Pyramidal cell communication within local networks in layer 2/3 of rat neocortexCarl Holmgren
Karolinska Institute, Department of Neuroscience, , B2-2, S-17177 Stockholm, Sweden
J Physiol 551:139-53. 2003..With such a high degree of connectivity with surrounding pyramidal cells, local interneurons are ideally poised to both coordinate and expand the local pyramidal cell network via pyramidal-interneuron-pyramidal communication... - Spontaneous cortical activity in awake monkeys composed of neuronal avalanchesThomas Petermann
Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:15921-6. 2009..Such scale-invariance has ontogenetic and phylogenetic implications because it allows large increases in network capacity without a fundamental reorganization of the system... - Large-scale recording of neuronal ensemblesGyorgy Buzsaki
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 7:446-51. 2004.... - Excitatory cortical neurons form fine-scale functional networksYumiko Yoshimura
Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 433:868-73. 2005.... - Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording studyThomas Nevian
Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
Nat Neurosci 10:206-14. 2007..remote from the soma (>30-fold excitatory postsynaptic potential (EPSP) attenuation) and back-propagating action potentials were significantly attenuated... - Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortexChristoph Kapfer
Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
Nat Neurosci 10:743-53. 2007..These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell... - Place cells, grid cells, and the brain's spatial representation systemEdvard I Moser
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Annu Rev Neurosci 31:69-89. 2008.... - The normalization model of attentionJohn H Reynolds
Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
Neuron 61:168-85. 2009.... - Behavior-dependent short-term assembly dynamics in the medial prefrontal cortexShigeyoshi Fujisawa
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 11:823-33. 2008..Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets... - A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effectsWilson Truccolo
Neuroscience Department, Brown University, Providence, RI, USA
J Neurophysiol 93:1074-89. 2005..The framework thus allows for the formulation and analysis of point process models of neural spiking activity that readily capture the simultaneous effects of multiple covariates and enables the assessment of their relative importance... - Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagationWenqin Hu
Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Nat Neurosci 12:996-1002. 2009..However, it is not clear why action potentials are not initiated at the proximal AIS, which has a similarly high Na(+) channel density... - Coordinated memory replay in the visual cortex and hippocampus during sleepDaoyun Ji
The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Neurosci 10:100-7. 2007..These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process... - Functional connectome of the striatal medium spiny neuronNao Chuhma
Department of Psychiatry and Pharmacology, Columbia University, New York, NY 10032, USA
J Neurosci 31:1183-92. 2011..This optogenetic approach defines the functional connectome of the striatal medium spiny neuron... - Lateral competition for cortical space by layer-specific horizontal circuitsHillel Adesnik
Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0634, USA
Nature 464:1155-60. 2010..Through this mechanism, cortical domains exploit horizontal projections to compete for cortical space... - Oscillatory phase coupling coordinates anatomically dispersed functional cell assembliesRyan T Canolty
Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 107:17356-61. 2010..These findings suggest that neuronal oscillations enable selective and dynamic control of distributed functional cell assemblies... - Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networksAndrea Hasenstaub
Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Neuron 47:423-35. 2005..Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex... - Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cellsTheofanis Karayannis
Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom
J Neurosci 30:9898-909. 2010..Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex... - Regulation of spike timing in visual cortical circuitsPaul Tiesinga
Physics and Astronomy Department, University of North Carolina at Chapel Hill, North Carolina 27599 3255, USA
Nat Rev Neurosci 9:97-107. 2008A train of action potentials (a spike train) can carry information in both the average firing rate and the pattern of spikes in the train... - Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movementsNatsuko Shichinohe
Department of Physiology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
Neuron 62:717-32. 2009..These results suggest an important role for the SEF in memory and assessment of visual motion direction and the programming of appropriate pursuit eye movements... - Stimulus onset quenches neural variability: a widespread cortical phenomenonMark M Churchland
Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
Nat Neurosci 13:369-78. 2010..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input... - Sampling properties of the spectrum and coherency of sequences of action potentialsM R Jarvis
Division of Biology, California Institute of Technology, Pasadena, California, USA
Neural Comput 13:717-49. 2001..Although the material discussed is of general applicability to point processes, attention will be confined to sequences of neuronal action potentials (spike trains), the motivation for this work. - Stimulus dependence of neuronal correlation in primary visual cortex of the macaqueAdam Kohn
Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 25:3661-73. 2005.... - Fragmentation of grid cell maps in a multicompartment environmentDori Derdikman
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway
Nat Neurosci 12:1325-32. 2009..These results indicate that spatial environments are represented in entorhinal cortex and hippocampus as a mosaic of discrete submaps that correspond to the geometric structure of the space... - Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axisLindsey L Glickfeld
Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
Nat Neurosci 12:21-3. 2009.... - Processing of low-probability sounds by cortical neuronsNachum Ulanovsky
Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
Nat Neurosci 6:391-8. 2003..Our results thus indicate that A1 neurons, in addition to processing the acoustic features of sounds, may also be involved in sensory memory and novelty detection... - Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptorsM Victoria Puig
Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
J Neurosci 30:2211-22. 2010..These results may provide insight into impaired serotonergic control of network activity in psychiatric illnesses such as schizophrenia and depression... - Effects of synaptic noise and filtering on the frequency response of spiking neuronsN Brunel
LPS, , Paris, France
Phys Rev Lett 86:2186-9. 2001..Thus, through its effect on noise inputs, realistic synaptic dynamics can ensure unlagged neuronal responses to high-frequency inputs... - Evaluating causal relations in neural systems: granger causality, directed transfer function and statistical assessment of significanceM Kaminski
Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton 33431, USA
Biol Cybern 85:145-57. 2001..In addition, we propose a method to assess the significance of causality measures. Finally, we demonstrate the applications of these measures to simulated data and actual neurobiological recordings... - Predicting spike timing of neocortical pyramidal neurons by simple threshold modelsRenaud Jolivet
Ecol Polytechnique Federale de Lausanne EPFL, School of Computer and Communication Sciences and Brain Mind Institute, Station 15, CH 1015, Lausanne, Switzerland
J Comput Neurosci 21:35-49. 2006.... - The structure of multi-neuron firing patterns in primate retinaJonathon Shlens
Department of Systems Neurobiology, The Salk Institute, La Jolla, California 92037, USA
J Neurosci 26:8254-66. 2006..This approach provides a way to define limits on the complexity of network interactions and thus may be relevant for probing the function of many neural circuits... - Hemodynamic signals correlate tightly with synchronized gamma oscillationsJörn Niessing
Max Planck Institute for Brain Research, 60528 Frankfurt M, Germany
Science 309:948-51. 2005..These are more closely related to local field potentials (LFPs) than to action potentials. We simultaneously recorded electrical and hemodynamic responses in the cat visual cortex... - The temporal structures and functional significance of scale-free brain activityBiyu J He
Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuron 66:353-69. 2010..Our findings reveal robust temporal structures and behavioral significance of scale-free brain activity and should motivate future study on its physiological mechanisms and cognitive implications... - Power-law scaling in the brain surface electric potentialKai J Miller
Department of Physics, University of Washington, Seattle, Washington, USA
PLoS Comput Biol 5:e1000609. 2009.... - Bayesian estimation of synaptic physiology from the spectral responses of neural massesR J Moran
The School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Dublin, Ireland
Neuroimage 42:272-84. 2008..These inferences were consistent with predictions derived from experimental microdialysis measures of extracellular glutamate levels... - Top-down versus bottom-up control of attention in the prefrontal and posterior parietal corticesTimothy J Buschman
Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 315:1860-2. 2007..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies... - Functional diversity and specificity of neostriatal interneuronsJames M Tepper
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Curr Opin Neurobiol 14:685-92. 2004..Both classes of interneurons are important sites of action of neuromodulators in neostriatum, and act in different but complementary ways to modify the activity of the spiny projection neurons... - Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus networkP J Magill
Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Neuroscience 106:313-30. 2001..Furthermore, the relative contribution of rate and pattern to aberrant information coding is intimately related to the state of activation of the cerebral cortex... - Requirement for hippocampal CA3 NMDA receptors in associative memory recallKazu Nakazawa
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 297:211-8. 2002..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall... - Dissociated cortical networks show spontaneously correlated activity patterns during in vitro developmentMichela Chiappalone
Neuroengineering and Bio nano Technology NBT Group, Department of Biophysical and Electronic Engineering DIBE, University of Genova, Via Opera Pia 11a, 16145, Genova, Italy
Brain Res 1093:41-53. 2006.... - How spike generation mechanisms determine the neuronal response to fluctuating inputsNicolas Fourcaud-Trocmé
Centre National de la Recherche Scientifique Unité Mixte de Recherche 8119, Neurophysique et Physiologie du Système Moteur, Unité de Formation et de Recherche Biomédicale, Universite Paris 5 Rene Descartes, 75270 Paris Cedex 06, France
J Neurosci 23:11628-40. 2003..Our study shows how an intrinsic neuronal property (the characteristics of fast sodium channels) determines the speed with which neurons can track changes in input... - Extracting non-linear integrate-and-fire models from experimental data using dynamic I-V curvesLaurent Badel
Laboratory of Computational Neuroscience, School of Computer and Communications Sciences and Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015, Lausanne, Switzerland
Biol Cybern 99:361-70. 2008..The method therefore provides a useful tool for the construction of tractable models and rapid experimental classification of cortical neurons... - The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitroHarold Köndgen
Department of Physiology, University of Bern, Bern CH 3012, Switzerland
Cereb Cortex 18:2086-97. 2008..Finally, above 200 Hz, the response amplitude decays as a power-law with an exponent that is independent of voltage fluctuations induced by the background noise... - Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxietyAvishek Adhikari
Department of Biological Sciences, Columbia University, New York, NY 10032, USA
Neuron 65:257-69. 2010..They are consistent with the notion that such synchronization is a general mechanism by which the hippocampus communicates with downstream structures of behavioral relevance... - A review of the integrate-and-fire neuron model: I. Homogeneous synaptic inputA N Burkitt
The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Vic, 3002, Australia
Biol Cybern 95:1-19. 2006..A brief overview is given of two issues in neural information processing that the integrate-and-fire neuron model has contributed to - the irregular nature of spiking in cortical neurons and neural gain modulation... - Firing modes of midbrain dopamine cells in the freely moving ratB I Hyland
Department of Physiology, School of Medical Sciences, University of Otago, P O Box 913, Dunedin, New Zealand
Neuroscience 114:475-92. 2002..1) In most cases, slowly firing cells with broad action potentials were profoundly inhibited by the dopamine agonist apomorphine, consistent with previously accepted criteria... - Human memory strength is predicted by theta-frequency phase-locking of single neuronsUeli Rutishauser
Computation and Neural Systems and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Nature 464:903-7. 2010..These findings provide a link between the known modulation of theta oscillations by many memory-modulating behaviours and circuit mechanisms of plasticity... - Dynamics of the firing probability of noisy integrate-and-fire neuronsNicolas Fourcaud
Laboratoire de Physique Statistique, Ecole Normale Superieure, 75231 Paris Cedex 05, France
Neural Comput 14:2057-110. 2002..In both cases, we determine, using numerical simulations, an effective decay time constant that describes the neuronal response completely... - Emergence of network structure due to spike-timing-dependent plasticity in recurrent neuronal networks. II. Input selectivity--symmetry breakingMatthieu Gilson
Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, VIC 3010, Australia
Biol Cybern 101:103-14. 2009..Consequently STDP generates a functional structure on the input connections of the network... - Population dynamics under the Laplace assumptionAndré C Marreiros
The Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuroimage 44:701-14. 2009..The mean-field model presented here will form the basis of a dynamic causal model of observed electromagnetic signals in future work... - GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibitionK Ganguly
Program in Neuroscience, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
Cell 105:521-32. 2001..In contrast, blockade of glutamatergic transmission or action potentials has no effect... - Cell-attached measurements of the firing threshold of rat hippocampal neuronesD Fricker
Laboratoire de Neurobiologie Cellulaire, INSERM U261, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
J Physiol 517:791-804. 1999..At potentials close to threshold, the rate of inactivation of Na+ and K+ followed a double exponential time course, such that Na+ currents were 62 % inactivated and K+ currents were 63 % inactivated within 15 ms... - Patterns of spatio-temporal correlations in the neural activity of the cat motor cortex during trained forelimb movementsSoumya Ghosh
Centre for Neuromuscular and Neurological Disorders, University of Western Australia, QEII Medical Centre, Nedlands, WA, Australia
Somatosens Mot Res 26:31-49. 2009..The observed synchronization of action potentials among selected but functionally varied groups of MI neurons possibly reflects dynamic recruitment of network .. - Cellular mechanisms underlying burst firing in substantia nigra dopamine neuronsSarah N Blythe
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 29:15531-41. 2009..Together, these data suggest that SN DA neurons integrate their synaptic input in a more conventional manner than was hypothesized previously... - Avalanches in a stochastic model of spiking neuronsMarc Benayoun
Department of Pediatrics, University of Chicago, Chicago, Illinois, USA
PLoS Comput Biol 6:e1000846. 2010.... - A threshold equation for action potential initiationJonathan Platkiewicz
Laboratoire Psychologie de la Perception, CNRS and Université Paris Descartes, Paris, France
PLoS Comput Biol 6:e1000850. 2010..We conclude that ionic channels can account for large variations in spike threshold... - A neural mass model of spectral responses in electrophysiologyR J Moran
The Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London, WC1N 3BG, UK
Neuroimage 37:706-20. 2007..In short, this work establishes a forward or generative model of electrophysiological recordings for psychopharmacological studies... - Self-organized criticality in developing neuronal networksChristian Tetzlaff
Bernstein Center for Computational Neuroscience, Institute of Physics III Biophysics, Georg August Universitat, Gottingen, Germany
PLoS Comput Biol 6:e1001013. 2010..These results demonstrate that the interplay between activity and connectivity guides developing networks into criticality suggesting that this may be a generic and stable state of many networks in vivo and in vitro... - Reinforcement learning, spike-time-dependent plasticity, and the BCM ruleDorit Baras
Neural Comput 19:2245-79. 2007..Finally, through statistical analysis, we show that the synaptic plasticity rule established is closely related to the widely used BCM rule, for which good biological evidence exists... - Sparse representation of sounds in the unanesthetized auditory cortexTomás Hromádka
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, Cold Spring Harbor, New York, United States of America
PLoS Biol 6:e16. 2008..Our results are compatible with a model in which most neurons are silent much of the time, and in which representations are composed of small dynamic subsets of highly active neurons... - The brain's router: a cortical network model of serial processing in the primate brainAriel Zylberberg
Laboratory of Integrative Neuroscience, Physics Department, University of Buenos Aires, Buenos Aires, Argentina
PLoS Comput Biol 6:e1000765. 2010.... - Temporal and spatial alterations in GPi neuronal encoding might contribute to slow down movement in Parkinsonian monkeysArthur Leblois
Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Universite Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Eur J Neurosci 24:1201-8. 2006..Parkinsonian bradykinesia could thus result from an impairment of both temporal and spatial specificity of the GPi response to movement... - Activity modulation elicited by electrical stimulation in networks of dissociated cortical neuronsPaolo Massobrio
Neuroengineering and Bio Nano Technology Group, Department of Biophysical and Electronic Engineering, University of Genova, Via Opera Pia 11a, 16145, Genova, Italy
Conf Proc IEEE Eng Med Biol Soc 2007:3008-11. 2007..The results allow to anticipate on integration of this work in goal-directed stimulus-induced plasticity...
Research Grants
- SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLEJohn Adelman; Fiscal Year: 2001..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
- Genetic mechanisms of myelination in zebrafishWilliam S Talbot; Fiscal Year: 2010..system, Schwann cells form the myelin sheath that wraps axons and allows for the rapid transmission of action potentials. Disruption of myelin causes peripheral neuropathies, debilitating diseases that affect 1...
- Properties of Ion Channels that Control SecretionJOHN ENYEART; Fiscal Year: 2007..ACTH- and All-stimulated cortisol and aldosterone secretion that depends on the generation of Ca2+-dependent action potentials. Specifically, the inhibition of bTREK-1 K+ channels by ACTH and All leads to action potentials driven by ..
- Hybrid Nanostructures for Wireless In Vivo Action Potential SensingJoshua Goldberger; Fiscal Year: 2007The use of electrochemical probes for sensing the action potentials of neuron cells in vitro and in vivo has led to much of our basic understanding concerning the mechanisms of nerve cell signaling...
- NEURAL SUBSTRATES OF COGNITIVE DECLINE IN AGING MONKEYSDOUGLAS ROSENE; Fiscal Year: 2007..cohorts 1 and 3, perfusion fixation will be preceded by in vivo neurophysiological assessment of compound action potentials. Then the two stage perfusion will follow to allow immediate collection of unfixed samples from one ..
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
- Selective targeting of sodium channel blockers to pain-sensing neuronsBruce P Bean; Fiscal Year: 2010Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
- Selective targeting of sodium channel blockers to pain-sensing neuronsBruce P Bean; Fiscal Year: 2010Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
- Factors that Initiate Arrhythmias in lung QT SyndromeGuy Salama; Fiscal Year: 2004..branches, will be perfused, stained with voltage and Ca2+ sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca2+ (Ca1) transients from 256 sites at high spatial and temporal resolution...
- Excitation-contraction Coupling in Normal and Dystrophic Mammalian MuscleJulio L Vergara; Fiscal Year: 2010..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the ..
- Spontaneous activity in the developing cochleaDwight E Bergles; Fiscal Year: 2010..In the developing cochlea, bursts of action potentials occur in afferent spiral ganglion neurons prior to the onset of hearing, activity that has been traced to ..
- GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITYLeon Avery; Fiscal Year: 2003..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
- Neurons in the subcallosal slingLinda Richards; Fiscal Year: 2005..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
- STRUCTURE/FUNCTION OF THE PACEMAKING AND CONDUCTION SYSTEM OF THE HEARTIgor Efimov; Fiscal Year: 2009..complex structure orchestrating orderly contractions of the cardiac chambers by generating and transmitting action potentials at an appropriate rate, conduction velocity, and incorporating a delay between the chambers to allow for ..
- STRUCTURE/FUNCTION OF THE PACEMAKING AND CONDUCTION SYSTEM OF THE HEARTIgor R Efimov; Fiscal Year: 2010..complex structure orchestrating orderly contractions of the cardiac chambers by generating and transmitting action potentials at an appropriate rate, conduction velocity, and incorporating a delay between the chambers to allow for ..
- NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERSRiyi Shi; Fiscal Year: 2003..polymer, polyethylene glycol (PEG), the investigators have successfully restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
- MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND RECDouglas McCreery; Fiscal Year: 2002..In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording ..
- Modulation of cardiac K+ channels by drugsMichael Sanguinetti; Fiscal Year: 2004Drugs that block the rapid delayed rectifier K+ current (Ikr) cause prolongation of cardiac action potentials and electrical refractoriness...
- Neurogenic Calcium Signals in Small ArteriesWITHROW WIER; Fiscal Year: 2007..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...