action potentials

Summary

Summary: The electric response of a nerve or muscle to its stimulation.

Top Publications

  1. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
  3. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
  4. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
  5. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
  6. ncbi Neural correlations, population coding and computation
    Bruno B Averbeck
    Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Neurosci 7:358-66. 2006
  7. pmc Single action potentials and subthreshold electrical events imaged in neurons with a fluorescent protein voltage probe
    Lei Jin
    Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuron 75:779-85. 2012
  8. pmc Highly selective receptive fields in mouse visual cortex
    Cristopher M Niell
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:7520-36. 2008
  9. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
  10. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010

Detail Information

Publications286 found, 100 shown here

  1. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    ..These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output...
  3. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
    ..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment...
  4. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
    ..Thus, a flexible pattern of coherence defines a flexible communication structure, which subserves our cognitive flexibility...
  5. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  6. ncbi Neural correlations, population coding and computation
    Bruno B Averbeck
    Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Neurosci 7:358-66. 2006
    ..Here, we review studies that address the interaction between neuronal noise and population codes, and discuss their implications for population coding in general...
  7. pmc Single action potentials and subthreshold electrical events imaged in neurons with a fluorescent protein voltage probe
    Lei Jin
    Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuron 75:779-85. 2012
    ..We show that the combination of signal size and response speed of these new probes allows the reliable detection of single action potentials and excitatory potentials in individual neurons and dendrites.
  8. pmc Highly selective receptive fields in mouse visual cortex
    Cristopher M Niell
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:7520-36. 2008
    ..This quantitative description of receptive field properties should facilitate the use of mouse visual cortex as a system to address longstanding questions of visual neuroscience and cortical processing...
  9. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
    ..Thus, single dendritic branches can already exhibit nonuniform synaptic integration, with the computational strategy shifting from temporal coding to rate coding along the dendrite...
  10. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
    ..Our findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated...
  11. pmc Spatio-temporal correlations and visual signalling in a complete neuronal population
    Jonathan W Pillow
    Gatsby Computational Neuroscience Unit, UCL, 17 Queen Square, London WC1N 3AR, UK
    Nature 454:995-9. 2008
    ..This model-based approach reveals the role of correlated activity in the retinal coding of visual stimuli, and provides a general framework for understanding the importance of correlated activity in populations of neurons...
  12. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR allows either knockout of single action potentials, or sustained blockade of spiking...
  13. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
    ..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies...
  14. pmc Weak pairwise correlations imply strongly correlated network states in a neural population
    Elad Schneidman
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 440:1007-12. 2006
    ..As a first test for the generality of these ideas, we show that similar results are obtained from networks of cultured cortical neurons...
  15. ncbi Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons
    N Brunel
    LPS, Ecole Normale Superieure, Paris, France
    J Comput Neurosci 8:183-208. 2000
    ..In the slow oscillatory state, the network frequency depends mostly on the membrane time constant. Finite size effects in the asynchronous state are also discussed...
  16. ncbi An energy budget for signaling in the grey matter of the brain
    D Attwell
    Department of Physiology, University College London, London, UK
    J Cereb Blood Flow Metab 21:1133-45. 2001
    ..b>Action potentials and postsynaptic effects of glutamate are predicted to consume much of the energy (47% and 34%, respectively)..
  17. pmc Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
    Joanna Mattis
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Methods 9:159-72. 2012
    ....
  18. pmc High-performance genetically targetable optical neural silencing by light-driven proton pumps
    Brian Y Chow
    The MIT Media Laboratory, Synthetic Neurobiology Group, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 463:98-102. 2010
    ..Light-driven proton pumps thus represent a high-performance and extremely versatile class of 'optogenetic' voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations...
  19. pmc The asynchronous state in cortical circuits
    Alfonso Renart
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Science 327:587-90. 2010
    ..Our results suggest a reexamination of the sources underlying observed correlations and their functional consequences for information processing...
  20. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
  21. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution...
  22. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
    ..This replay is suggestive of a role in the evaluation of event sequences in the manner of reinforcement learning models. We propose that such replay might constitute a general mechanism of learning and memory...
  23. pmc Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli
    Bassam V Atallah
    Computational Neurosciences Graduate Program, University of California San Diego, La Jolla, California 92093 0634, USA
    Neuron 73:159-70. 2012
    ..These results indicate that PV cells are ideally suited to modulate cortical gain and establish a causal relationship between a select neuron type and specific computations performed by the cortex during sensory processing...
  24. ncbi Memory of sequential experience in the hippocampus during slow wave sleep
    Albert K Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:1183-94. 2002
    ..This rapid encoding of sequential experience is consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans...
  25. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
  26. ncbi Modulation of neuronal interactions through neuronal synchronization
    Thilo Womelsdorf
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands
    Science 316:1609-12. 2007
    ..These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions...
  27. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  28. pmc A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
    Linda Madisen
    Allen Institute for Brain Science, Seattle, Washington, USA
    Nat Neurosci 15:793-802. 2012
    ..When combined with the hundreds of available Cre driver lines, this optimized toolbox of reporter mice will enable widespread investigations of neural circuit function with unprecedented reliability and accuracy...
  29. pmc The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability
    M V Tsodyks
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 94:719-23. 1997
    ..probability of neurotransmitter release, dictates the extent to which firing rate and temporal coherence of action potentials within a presynaptic population are signaled to the postsynaptic neuron...
  30. ncbi Dendritic organization of sensory input to cortical neurons in vivo
    Hongbo Jia
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Nature 464:1307-12. 2010
    ..Thus, orientation-tuned neurons can compute their characteristic firing pattern by integrating spatially distributed synaptic inputs coding for multiple stimulus orientations...
  31. ncbi GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
    P Bonifazi
    Institut de Neurobiologie de la Méditerranée INSERM U901, Universitéde la Méditerranée, Parc Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 9, France
    Science 326:1419-24. 2009
    ..These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony...
  32. ncbi Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    Alessandra Moretti
    Cardiology Division, First Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    N Engl J Med 363:1397-409. 2010
    ..In long-QT syndrome type 1, mutations occur in the KCNQ1 gene, which encodes the repolarizing potassium channel mediating the delayed rectifier I(Ks) current...
  33. pmc Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function
    Shengli Zhao
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA
    Nat Methods 8:745-52. 2011
    ..This resource of cell type–specific ChR2(H134R) mouse lines will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior...
  34. ncbi The gamma cycle
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:309-16. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  35. pmc High-frequency, long-range coupling between prefrontal and visual cortex during attention
    Georgia G Gregoriou
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1207-10. 2009
    ....
  36. ncbi What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance
    Nicolas Brunel
    Centre National de la Recherche Scientifique Neurophysique et Physiologie du Système Moteur Université Paris René Descartes, 75270 Paris Cedex 06, France
    J Neurophysiol 90:415-30. 2003
    ..Faster excitation than inhibition, or a higher excitation/inhibition ratio, favors the feedback loop and a much slower oscillation (typically in the gamma range)...
  37. pmc Attractor dynamics in the hippocampal representation of the local environment
    Tom J Wills
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Science 308:873-6. 2005
    ..This enables study of attractor dynamics in a cognitive representation and may correspond to the formation of distinct contexts in context-dependent memory...
  38. ncbi Connectivity reflects coding: a model of voltage-based STDP with homeostasis
    Claudia Clopath
    Laboratory of Computational Neuroscience, Brain Mind Institute and School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Nat Neurosci 13:344-52. 2010
    ..Thus, variable connectivity patterns in the brain could reflect different coding principles across brain areas; moreover, our simulations suggested that plasticity is fast...
  39. ncbi Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding
    Arvind Kumar
    Bernstein Center Freiburg and Faculty of Biology, University of Freiburg, Hansastrasse 9A, 79104, Freiburg, Germany
    Nat Rev Neurosci 11:615-27. 2010
    ..Here, we review the dichotomy of asynchronous and synchronous propagation in FFNs, propose their integration into a single extended conceptual framework and suggest experimental strategies to test our hypothesis...
  40. pmc Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
    Joel M Kralj
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 9:90-5. 2012
    Reliable optical detection of single action potentials in mammalian neurons has been one of the longest-standing challenges in neuroscience...
  41. ncbi Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition
    N Brunel
    LPS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
    J Comput Neurosci 11:63-85. 2001
    ..The present study therefore points to several mechanisms that enhance the signal-to-noise ratio in working memory states. These mechanisms could be implemented in the prefrontal cortex by dopaminergic projections from the midbrain...
  42. ncbi Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering
    R Quian Quiroga
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, U S A
    Neural Comput 16:1661-87. 2004
    ..For these data sets, we found that the proposed algorithm outperformed conventional methods...
  43. pmc Measuring and interpreting neuronal correlations
    Marlene R Cohen
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:811-9. 2011
    ..Given these complicating factors, we offer guidelines for interpreting correlation data and a discussion of how best to evaluate the effect of correlations on cortical processing...
  44. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
    ....
  45. ncbi Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition
    Bilal Haider
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:4535-45. 2006
    ....
  46. pmc Attention improves performance primarily by reducing interneuronal correlations
    Marlene R Cohen
    Howard Hughes Medical Institute and Harvard Medical School Department of Neurobiology, Boston, Massachusetts, USA
    Nat Neurosci 12:1594-600. 2009
    ..These results suggest that the representation of sensory information in populations of neurons and the way attention affects the sensitivity of the population may only be understood by considering the interactions between neurons...
  47. ncbi Ultrafast optogenetic control
    Lisa A Gunaydin
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Neurosci 13:387-92. 2010
    ....
  48. ncbi Sparse coding of sensory inputs
    Bruno A Olshausen
    Center for Neuroscience, UC Davis, 1544 Newton Court, Davis, California 95616, USA
    Curr Opin Neurobiol 14:481-7. 2004
    ..Recent physiological recordings from sensory neurons have indicated that sparse coding could be a ubiquitous strategy employed in several different modalities across different organisms...
  49. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
    ..Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation...
  50. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
    ..almost entirely for the large trial-to-trial variability of sensory-evoked postsynaptic potentials and action potentials. Subthreshold sensory synaptic responses evoked while a cortical area was spontaneously depolarized were ..
  51. pmc The normalization model of attention
    John H Reynolds
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Neuron 61:168-85. 2009
    ....
  52. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  53. pmc An oscillatory interference model of grid cell firing
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, United Kingdom
    Hippocampus 17:801-12. 2007
    ..Predictions of the interference model are given for the frequency composition of EEG power spectra and temporal autocorrelograms of grid cell firing as functions of the speed and direction of running and the novelty of the environment...
  54. ncbi Alternans and spiral breakup in a human ventricular tissue model
    K H W J ten Tusscher
    Utrecht University, Department of Theoretical Biology, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1088-100. 2006
    ..Therefore, we conclude that steep APD restitution-mediated instability is a potential mechanism for VF in the human heart...
  55. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed ..
  56. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
    ..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
  57. ncbi Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Physiol Rev 84:431-88. 2004
    ..This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart...
  58. pmc Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  59. pmc Dense inhibitory connectivity in neocortex
    Elodie Fino
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Neuron 69:1188-203. 2011
    ..We conclude that local inhibitory connectivity is promiscuous, does not form subnetworks, and can approach the theoretical limit of a completely connected synaptic matrix...
  60. ncbi Variability, compensation and homeostasis in neuron and network function
    Eve Marder
    Volen Center and Biology Department, MS 013 Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 7:563-74. 2006
    ....
  61. ncbi Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
    Michael Okun
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Neurosci 11:535-7. 2008
    ....
  62. pmc Synchronous oscillatory neural ensembles for rules in the prefrontal cortex
    Timothy J Buschman
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 76:838-46. 2012
    ..Synchrony may act to dynamically shape task-relevant neural ensembles out of larger, overlapping circuits...
  63. pmc Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment
    Pietro Berkes
    Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Science 331:83-7. 2011
    ..This demonstrates the progressive adaptation of internal models to the statistics of natural stimuli at the neural level...
  64. pmc Spontaneous cortical activity in awake monkeys composed of neuronal avalanches
    Thomas Petermann
    Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:15921-6. 2009
    ..Such scale-invariance has ontogenetic and phylogenetic implications because it allows large increases in network capacity without a fundamental reorganization of the system...
  65. pmc Forward and reverse hippocampal place-cell sequences during ripples
    Kamran Diba
    Center for Molecular and Behavioral Neurobiology, Rutgers University, 197 University Ave, Newark, New Jersey 07102, USA
    Nat Neurosci 10:1241-2. 2007
    ..This bidirectional re-enactment of temporal sequences may contribute to the establishment of higher-order associations in episodic memory...
  66. pmc Start/stop signals emerge in nigrostriatal circuits during sequence learning
    Xin Jin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892 9412, USA
    Nature 466:457-62. 2010
    ..These results have important implications for understanding the functional organization of actions and the sequence initiation and termination impairments observed in basal ganglia disorders...
  67. ncbi Tonically active GABA A receptors: modulating gain and maintaining the tone
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Trends Neurosci 27:262-9. 2004
    ....
  68. ncbi Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    M A Cowley
    The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    Nature 411:480-4. 2001
    ..Leptin increases the frequency of action potentials in the anorexigenic POMC neurons by two mechanisms: depolarization through a nonspecific cation channel; and ..
  69. ncbi Nonlinear multivariate analysis of neurophysiological signals
    Ernesto Pereda
    Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, Avda Astrofísico Fco Sánchez s n, 38205 La Laguna, Tenerife, Spain
    Prog Neurobiol 77:1-37. 2005
    ..Finally, we illustrate the use of multivariate surrogate data test for the assessment of the strength (strong or weak) and the type (linear or nonlinear) of interdependence between neurophysiological signals...
  70. ncbi The action potential in mammalian central neurons
    Bruce P Bean
    Harvard Medical School, Department of Neurobiology, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 8:451-65. 2007
    ..This rich repertoire of channels allows neurons to encode information by generating action potentials with a wide range of shapes, frequencies and patterns...
  71. ncbi Large-scale recording of neuronal ensembles
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 7:446-51. 2004
    ....
  72. ncbi Evaluating causal relations in neural systems: granger causality, directed transfer function and statistical assessment of significance
    M Kaminski
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton 33431, USA
    Biol Cybern 85:145-57. 2001
    ..In addition, we propose a method to assess the significance of causality measures. Finally, we demonstrate the applications of these measures to simulated data and actual neurobiological recordings...
  73. ncbi Signal propagation and logic gating in networks of integrate-and-fire neurons
    Tim P Vogels
    Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:10786-95. 2005
    ..Using this feature, we show how different types of logic gates can arise within the architecture of the random network through the strengthening of specific synapses...
  74. pmc High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
    Andre Berndt
    Experimental Biophysics, Humboldt Universitat zu Berlin, D 10115 Berlin, Germany
    Proc Natl Acad Sci U S A 108:7595-600. 2011
    Channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience, allowing precise induction of action potentials with short light pulses...
  75. pmc Spatial and temporal scales of neuronal correlation in primary visual cortex
    Matthew A Smith
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:12591-603. 2008
    ..These properties and the circuit mechanism they imply provide new constraints on the functional role that correlation may play in visual processing...
  76. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  77. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  78. ncbi An ultra-sparse code underlies the generation of neural sequences in a songbird
    Richard H R Hahnloser
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    Nature 419:65-70. 2002
    ....
  79. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    ..Here, we induced cardiomyocyte differentiation of hES cells by a novel method and compared their electrophysiological properties and coupling with those of primary human fetal cardiomyocytes...
  80. pmc Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4
    Jude F Mitchell
    Systems Neurobiology Lab, The Salk Institute, La Jolla, CA 92037 1099, USA
    Neuron 63:879-88. 2009
    ..This attention-dependent reduction of ongoing cortical activity improves the signal-to-noise ratio of pooled neural signals substantially more than attention-dependent increases in firing rate...
  81. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    ..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
  82. ncbi Spike synchronization and rate modulation differentially involved in motor cortical function
    A Riehle
    Center for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
    Science 278:1950-3. 1997
    ..of a delayed-pointing task exhibited context-dependent, rapid changes in the patterns of coincident action potentials. Accurate spike synchronization occurred in relation to external events (stimuli, movements) and was ..
  83. ncbi Real-time computing without stable states: a new framework for neural computation based on perturbations
    Wolfgang Maass
    Institute for Theoretical Computer Science, Technische Universitat Graz, A 8010 Graz, Austria
    Neural Comput 14:2531-60. 2002
    ..Our approach provides new perspectives for the interpretation of neural coding, the design of experiments and data analysis in neurophysiology, and the solution of problems in robotics and neurotechnology...
  84. ncbi Multiple neural spike train data analysis: state-of-the-art and future challenges
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
    Nat Neurosci 7:456-61. 2004
    ..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research...
  85. ncbi How connectivity, background activity, and synaptic properties shape the cross-correlation between spike trains
    Srdjan Ostojic
    Institut des Systemes Complexes Paris Ile de France and Laboratoire de Physique Statistique, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Universite Paris Diderot, Ecole Normale Superieure, Paris, France
    J Neurosci 29:10234-53. 2009
    ..In particular, we show that the postsynaptic neuron spiking regularity has a pronounced influence on CCF amplitude. This suggests an efficient and flexible mechanism for modulating functional interactions...
  86. ncbi Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
    ..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience...
  87. ncbi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    ..After a nerve lesion, these mice showed no neuropathic pain in response to thermal or mechanical stimuli. Neuropathic pain is therefore initiated by HCN2-driven action potential firing in Na(V)1.8-expressing nociceptors...
  88. ncbi Developing networks play a similar melody
    Y Ben-Ari
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Cedex 09, Marseille, France
    Trends Neurosci 24:353-60. 2001
    ....
  89. ncbi Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
    Jonathan Fritz
    Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Neurosci 6:1216-23. 2003
    ..Some receptive field changes persisted for hours after the task was over and hence may contribute to long-term sensory memory...
  90. ncbi Place cells, grid cells, and the brain's spatial representation system
    Edvard I Moser
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Annu Rev Neurosci 31:69-89. 2008
    ....
  91. ncbi The metabolic cost of neural information
    S B Laughlin
    Department of Zoology, University of Cambridge, UK
    Nat Neurosci 1:36-41. 1998
    ..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
  92. pmc Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop
    Kenji Mizuseki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 64:267-80. 2009
    ..We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop...
  93. ncbi Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..responses were evoked in layer 5 PCs following stimulation of individual neighboring PCs with trains of action potentials. The probability for inhibition between PCs was more than twice that of direct excitation, and inhibitory ..
  94. ncbi A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects
    Wilson Truccolo
    Neuroscience Department, Brown University, Providence, RI, USA
    J Neurophysiol 93:1074-89. 2005
    ..The framework thus allows for the formulation and analysis of point process models of neural spiking activity that readily capture the simultaneous effects of multiple covariates and enables the assessment of their relative importance...
  95. ncbi Neuronal coherence as a mechanism of effective corticospinal interaction
    Jan Mathijs Schoffelen
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EK Nijmegen, Netherlands
    Science 308:111-3. 2005
    ..This coherence may contribute to an effective corticospinal interaction and shortened reaction times...
  96. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..In view of the high firing rates in the functionally disconnected state of slow-wave sleep, we suggest that neocortical neurons are engaged in processing internally generated signals...
  97. ncbi KCNQ1 gain-of-function mutation in familial atrial fibrillation
    Yi Han Chen
    Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People s Republic of China
    Science 299:251-4. 2003
    ..Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes...
  98. pmc Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies
    Ryan T Canolty
    Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:17356-61. 2010
    ..These findings suggest that neuronal oscillations enable selective and dynamic control of distributed functional cell assemblies...
  99. ncbi Distinct ensemble codes in hippocampal areas CA3 and CA1
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1295-8. 2004
    ..In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently...
  100. ncbi Correlation between neural spike trains increases with firing rate
    Jaime de la Rocha
    Center for Neural Science, New York University, New York 10003, USA
    Nature 448:802-6. 2007
    ..thalamus, and several cortical regions show temporal correlation between the discharge times of their action potentials (spike trains)...
  101. ncbi Turning on and off recurrent balanced cortical activity
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 423:288-93. 2003
    ..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex...

Research Grants75

  1. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2001
    ..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
  2. Neurogenic Calcium Signals in Small Arteries
    WITHROW WIER; Fiscal Year: 2007
    ..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...
  3. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..polymer, polyethylene glycol (PEG), the investigators have successfully restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  4. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording ..
  5. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..and Ca2+ imaging studies of these cells revealed irregular contraction, excess Ca2+ influx, prolonged action potentials, delayed afterdepolarizations and irregular Ca2+ signaling...
  6. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..and Ca2+ imaging studies of these cells revealed irregular contraction, excess Ca2+ influx, prolonged action potentials, delayed afterdepolarizations and irregular Ca2+ signaling...
  7. Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibit
    Peter J Burke; Fiscal Year: 2012
    ..To accomplish this objective, we propose to extend studies that have monitored the action potentials in neurons using an array of parallel electrodes to which the mitochondria are adhered...
  8. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..My main hypothesis is that axons that lose myelin have a disrupted distribution of ion channels, action potentials timing, and an altered handling of Ca2+ and Na+ ion influx...
  9. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..rapid pacing;c) correlating the metabolic observations with electric, optical, and magnetic measurements of action potentials, action and injury currents, membrane capacitive and ionic currents, and stimulation currents;and d) ..
  10. Epithelial Sodium Channels in Vasopressin and Oxytocin Synthesizing Magnocellular
    Ryoichi Teruyama; Fiscal Year: 2013
    ..study demonstrated that ENaC is a Na+-leak current modulating membrane potential and affecting the frequency action potentials evoked in MNCs (18)...
  11. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..Aim Bi) Identify age and thyroid hormone dependent triggering of ectopic action potentials in the presence of target-specific autonomic AA in a canine pulmonary vein atrial sleeve tissue preparation ..
  12. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the ..
  13. Label-Free Chemical Imaging for Biological Applications
    Wei Min; Fiscal Year: 2012
    ..The intense electric field across the plasma membranes during action potentials should shift the vibrational frequency of membrane lipids, and we plan to employ this vibrational ..
  14. Central TRPV1 in Cardiovascular Regulation
    MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2013
    ..vesicle pool responsible for excitatory postsynaptic currents triggered at low jitter latency by afferent action potentials - a synchronous release process that appears identical in all solitary tract afferents...
  15. Cellular therapy for the inner ear
    Albert S Edge; Fiscal Year: 2013
    ..morphology and number of synapses formed with inner and outer hair cells;and electrophysiology: firing of action potentials and excitatory postsynaptic currents by the neurons after stimulation of hair cells, and inhibition of this ..
  16. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..Such a system would allow for the "moment to moment" regulation of centrally-directed action potentials in vagal afferents and transmission of afferent information into the brain...
  17. Physiological mechanisms responsible for cognitive impairments in Dravet Syndrome
    Pierre Pascal Lenck-Santini; Fiscal Year: 2013
    Voltage gated Sodium channels (Nav) are critical for the initiation and propagation of action potentials. Mutations of the SCN1A gene, which codes for Nav type 1...
  18. Molecular Dissection of Calmodulin Domain Functions
    Madeline A Shea; Fiscal Year: 2013
    ..fibrillation, familial autism, pain insensitivity, and other defects in the generation and propagation of action potentials. Most members of the NaV family of channels respond to calcium via regulation by calmodulin (CaM), an ..
  19. Titin Splicing Mechanisms and Physical Implications
    Marion L Greaser; Fiscal Year: 2010
    ..Studies will be conducted to characterize the prolonged duration of action potentials from cardiomyocytes of homozygous mutants and determine whether the altered ion channel properties found in ..
  20. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  21. MOLECULAR MECHANISMS OF AXONAL TRANSPORT
    SCOTT THOMAS BRADY; Fiscal Year: 2011
    ..in delivery of critical cargos by FAT can affect neuronal functions that include synaptic transmission, action potentials and neurotrophin supply...
  22. Mechanisms of Alcohol Withdrawal
    Dwayne W Godwin; Fiscal Year: 2012
    ..seizure is an abnormal brain rhythm that is produced in the thalamus by neurons firing rhythmic bursts of action potentials. These bursts depend upon a class of T-type calcium channels that are expressed within the brain and ..
  23. 2-pore-domain K+ channels as novel targets for modulating islet hormone secretion
    DAVID AARON JACOBSON; Fiscal Year: 2013
    ..a gap in our understanding of the background potassium currents that stabilize the [unreadable]?p from where action potentials fire during glucose stimulation...
  24. Roles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signaling
    Martin F Schneider; Fiscal Year: 2013
    ..monitor Ca2+ signals and calculate the underlying Ca2+ release flux from the SR during single or trains of action potentials in intact fibers, or during voltage clamp depolarization of whole cell voltage clamped fibers with high ..
  25. Stimulus processing in mammalian vestibular organs
    Ruth Anne Eatock; Fiscal Year: 2012
    ..We will examine the origins of specific patterns of activity (firing patterns of action potentials, also called spikes) in vestibular afferents...
  26. Acoustic and electrical hearing after Atoh1 treatment
    Bryan E Pfingst; Fiscal Year: 2010
    ..ear and assess psychophysical responses to electrical stimulation and electrically evoked compound action potentials (ECAPs) with and without restored IHCs. Controls with some surviving hair cells (i.e...
  27. Non-linear Characterization of the Stretch Reflex Arc and its Neuromodulation
    AMAN BEHAL; Fiscal Year: 2011
    ..white noise current injection in current clamp mode into patch-clamped cells with concurrent recording of action potentials (or contraction force in the case of the muscle)...
  28. The Role of ASICs in Migraine Pathophysiology
    Gregory O Dussor; Fiscal Year: 2013
    ..Following exposure to mast cell mediators, these small pH drops lead to firing of action potentials. Preliminary studies also show that direct application of decreased pH solutions to the dura mater of awake ..
  29. Epigenetic Regulation of Peripheral Nerve Myelination
    JOHN P SVAREN; Fiscal Year: 2013
    ..provided by applicant): Myelination of axons in the nervous system is critical for not only conduction of action potentials, but also for providing tropic support to ensure long term survival of neurons in both the central and ..
  30. Synaptic regulation of single substantia nigra pars reticulata neurons
    STEVEN WILLIAM JOHNSON; Fiscal Year: 2012
    ..Because STN stimulation evokes a burst of action potentials when recording under current-clamp, the complex EPSC may represent a novel mechanism for promoting burst ..
  31. Chemical biology of voltage-gated sodium and potassium channels
    Christopher A Ahern; Fiscal Year: 2013
    ..proteins underlie the regulation of basal electrical excitability and the initiation and repolarization of action potentials in virtually all excitable cells...
  32. Design of Slack Channel Activators
    Heike Wulff; Fiscal Year: 2012
    ..that follows repetitive firing, regulate rates of bursting and enhance the accuracy with which action potentials lock to incoming stimuli...
  33. Investigating the role of ribeye in retinal ribbon function
    DAVID PAUL ZENISEK; Fiscal Year: 2013
    ..cells of retina release neurotransmitter in a graded-continuous manner rather than in bursts in response to action potentials. To do so, these cells have evolved synaptic ribbons, proteinaceous structures that tether large numbers of ..
  34. Stem cell derived neurons and inherited epilepsy
    Miriam H Meisler; Fiscal Year: 2010
    ..We have been able to record action potentials from bipolar and pyramidal neurons...
  35. Long term consequences of white matter damage by perinatal hyperoxia.
    Vittorio Gallo; Fiscal Year: 2013
    ..of axons of the corpus callosum by measuring axonal conduction properties such as velocity and compound action potentials, and ii) changes in motor behavior using the motor skills sequence task test...
  36. Optogenetic inhibition of motor neuron and muscle activity in vivo
    Scott L Delp; Fiscal Year: 2013
    ..We will ask whether the application of light can block action potentials induced by electric nerve stimulation in a tunable and reversible manner and thereby prevent muscle ..
  37. DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONS
    Roger Y Tsien; Fiscal Year: 2013
    ..for measuring and/or manipulating neuronal messengers and signals such as calcium, glutamate, GABA, action potentials, surface exposure of selected proteins, singlet oxygen, protein-protein proximity over tens of nm, turnover ..
  38. Ca-Calmodulin Activated Phosphorylation Signaling Pathways in the Heart
    COURTNEY BLAKE NICHOLS; Fiscal Year: 2013
    ..e. action potentials) into mechanical process in the heart (i.e. contractions...
  39. Functional and molecular identification of TREK-1 channel in myometrium in relati
    Sang Don Koh; Fiscal Year: 2010
    ..Several K+ channels participate in the regulation of resting membrane potential and repolarization of action potentials in the myometrium...
  40. Molecular Physiology of Myotonia and Periodic Paralysis
    Stephen C Cannon; Fiscal Year: 2013
    ..Myotonia is a disorder of enhanced excitability wherein a single stimulus elicits a high- frequency burst of action potentials that produces involuntary persistent muscle contraction lasting seconds...
  41. Glial Proliferation and Death in Depression and Alcoholism
    Jose Javier Miguel Hidalgo; Fiscal Year: 2010
    ..neuronal pathology, because glial cells are essential in the regulation of neurotransmission, conduction of action potentials and neuronal metabolism...
  42. Hippocampal Synaptic Structure
    Philip W Landfield; Fiscal Year: 2013
    ..derived from the finding that the Ca2+-dependent slow afterhyperpolarization (sAHP), that follows a burst of action potentials in hippocampal pyramidal neurons, is larger in aged than in young-adult animals...
  43. Calcium Signals Within Membrane Nanotubes
    Ian F Smith; Fiscal Year: 2013
    ..sites to overcome limitations of passive diffusion in a chemical analog of electrical transmission of action potentials along axons...
  44. Novel Mechanisms of Visceral Pain: Functional Properties of Microglia
    Jennifer L Watts; Fiscal Year: 2012
    ..Since neuronal hyperexcitability is associated with VH, extracellular action potentials from spinal cord neurons will be recorded to determine whether there is a correlation between neuronal ..
  45. Regulation of auditory calcium channels
    Amy Lee; Fiscal Year: 2013
    Project Summary In cochlear inner hair cells (IHCs), Cav1.3 L-type voltage-gated Ca2+ channels mediate Ca2+ action potentials before the onset of hearing and Ca2+ signals that trigger exocytosis of neurotransmitter from IHCs onto ..
  46. Dynamic Aspects of Olfactory Signal Transduction
    Johannes Reisert; Fiscal Year: 2013
    ..ORNs recognize odorants and convert odorant stimulation into action potentials to be conveyed to the first relay station in the brain, the olfactory bulb...
  47. Postsynaptic Activity of Type II Cochlear Afferents
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2010
    ..to determine the likelihood that stimuli will produce enough activation of the dendritic field to generate action potentials that may then be transmitted centrally to be incorporated into our perception of auditory stimuli...
  48. Extrinsic Neural Control of Gastrointestinal Function in the Disordered Bowel
    David R Linden; Fiscal Year: 2012
    ..By impeding invading action potentials from causing norepinephrine release, enhanced 12A ARs would result in a reduction of sympathetic outflow to ..
  49. Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..core co-director, is an expert in optical mapping and was first to develop methods to simultaneously record action potentials and Ca2+ transients...
  50. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    ..Compound action potentials (CAPs) and auditory brainstem responses (ABRs) recorded in forward and simultaneous masking paradigms will ..
  51. Protective Effects of Anti-C5a in Sepsis
    Peter A Ward; Fiscal Year: 2013
    ..Aim 3 will assess electrophysiological responses (action potentials, Ca2+ transients, and K+ and Ca2+ currents) as well as functional responses (by measuring intracellular ..
  52. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    Project Summary/ Abstract Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
  53. CREB and Memory Allocation in the Basolateral Amygdala
    THOMAS W ROGERSON; Fiscal Year: 2012
    ..Unlike the ChR2, light-activation of ChR2-C128S does not necessarily trigger action potentials and instead increases the depolarization of these neurons, thus increasing their excitability...
  54. EXPRESSION AND FUNCTION OF K+ CHANNEL GENES IN BRAIN
    Bernardo Rudy; Fiscal Year: 2013
    ..interneuron known as the fast-spiking (FS) cell, named for its ability to fire sustained trains of action potentials (APs) at remarkably high frequencies...
  55. PS1 and BACE1 regulate processing and activity of voltage-gated sodium channels
    Dora M Kovacs; Fiscal Year: 2012
    ..junctions, voltage-gated sodium channels (VGSC) are almost exclusively responsible for the rising phase of action potentials. Either one or two (3 subunits can interact with a single pore-forming a-subunit to form the active VGSC on ..
  56. Molecular Properties of Voltage-Sensitive Calcium Channels
    William A Catterall; Fiscal Year: 2013
    ..These forms of short-term synaptic plasticity shape the postsynaptic response to trains of action potentials impinging on the presynaptic terminal and thereby encode information contained in the frequency and pattern ..
  57. The Contribution of Melanocyte-like Cells to Atrial Function and Development
    Vickas V Patel; Fiscal Year: 2013
    ..isolated murine melanocyte-like cells are electrically excitable and generate atrial myocyte-like action potentials. We have found that genetic deletion of the enzyme dopachrome tautomerase (Dct), which is expressed by both ..
  58. Auditory Cortex: Synaptic organization and plasticity
    Paul B Manis; Fiscal Year: 2013
    ..the hypotheses that dendritic potassium channels regulate calcium signaling produced by back-propagating action potentials in dendrites, and that these channels are in turn regulated by muscarinic receptor activation...
  59. Role of cGKII in AMPA Receptor Transport
    Edward B Ziff; Fiscal Year: 2013
    AMPA receptors generate the major depolarizing currents that trigger the formation of action potentials. Alterations of the rates of insertion and removal of receptors at synapses can modify receptor synaptic abundance and control ..
  60. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ..ganglia will obtained from mice actively sensitized to ovalbumin (OVA), and extracellular recording of action potentials from afferent nerves in the lungs and airway wall will be performed...
  61. Seizure-Induced Plasticity of the Ia Current in the Entorhinal Cortex
    STEPHANIE CARLSON; Fiscal Year: 2010
    ..To measure the la directly is very difficult, but because the la decreases the amplitude of back-propagating action potentials (bAPs), we will measure the amplitude of bAPs in control conditions and in the presence of an inhibitor of ..
  62. The role of spontaneous neurotransmission in synaptic plasticity and behavior
    Devon C Crawford; Fiscal Year: 2013
    ..In the absence of action potentials, however, some vesicles fuse spontaneously, releasing neurotransmitter in a sparse and temporally random ..
  63. Mechanisms Modulating Cytoskeletal Dynamics During Schwann Cell Myelination
    CRISTINA MARIA FERNANDEZ VALLE; Fiscal Year: 2010
    Myelination allows rapid propagation of action potentials in the nervous system. Dys- and demyelinating disorders are among the most common neurological pathologies affecting young adults...
  64. Calcium Signaling in the Brain Reward Circuit and Drug Addiction
    Hitoshi Morikawa; Fiscal Year: 2013
    ..Calcium signals triggered by postsynaptic action potentials are known to play a critical role in the plasticity of synapses in the brain...
  65. Determinants of Calcium Ion Influx into Dendritic Spines
    ANDREW GIESSEL; Fiscal Year: 2010
    ..are calcium signals in spines of CA1 pyramidal neurons influenced by near-coincident synaptic activity and action potentials? To address these questions, we will use a combination of whole-cell patch clamp physiology, 2-photon ..
  66. Linking Molecular and Electrical Rhythms in the Brain's Biological Clock
    Jeffrey R Jones; Fiscal Year: 2013
    ..These neurons can spontaneously fire action potentials, and, importantly, can modulate their firing rates so that they fire quickly during the day and slowly at ..
  67. NONASSOCIATIVE AND ASSOCIATIVE NEUROPLASTICITY
    Thomas W Abrams; Fiscal Year: 2013
    ..release sites are silenced, and burst dependent protection (BDP) from depression, in which a small burst of action potentials prevents the silencing of release sites...
  68. REGULATION OF SODIUM CHANNEL EXPRESSION
    ROBERT MAUE; Fiscal Year: 2000
    ..tightly controlled expression of Na channels is critical to the ability of neurons to generate and propagate action potentials, and as such is central to information transfer in the nervous system...
  69. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..In the developing cochlea, bursts of action potentials occur in afferent spiral ganglion neurons prior to the onset of hearing, activity that has been traced to ..
  70. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..release of LT by a TK supports the model of a "relay mediator" role for LTs in which they trigger antidromic action potentials or directly produce Ca+ mediated TK release; TKs, in turn, cause further LT release and the cascading spread ..
  71. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2003
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  72. REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 1999
    ..Basolateral ionic currents in dissociated cells (supporting and hair cells) and action potentials on primary afferents will be studied in vitro and in vivo, respectively...
  73. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2005
    ..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
  74. Afterhyperpolarization in dopamine neurons, H2O2 and KATP channels
    Marat Avshalumov; Fiscal Year: 2009
    ..pattern is the prolonged afterhyperpolarization (AHP) that follows a single action potential or burst of action potentials. In DA neurons the AHP contributes to the regulation of the frequency and pattern of spontaneous and evoked ..
  75. Hybrid Nanostructures for Wireless In Vivo Action Potential Sensing
    Joshua Goldberger; Fiscal Year: 2009
    The use of electrochemical probes for sensing the action potentials of neuron cells in vitro and in vivo has led to much of our basic understanding concerning the mechanisms of nerve cell signaling...