action potentials

Summary

Summary: The electric response of a nerve or muscle to its stimulation.

Top Publications

  1. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
  3. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
  4. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
  5. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
  6. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
  7. ncbi Neural correlations, population coding and computation
    Bruno B Averbeck
    Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Neurosci 7:358-66. 2006
  8. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
  9. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
  10. doi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011

Detail Information

Publications258 found, 100 shown here

  1. ncbi Millisecond-timescale, genetically targeted optical control of neural activity
    Edward S Boyden
    Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
    Nat Neurosci 8:1263-8. 2005
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers...
  2. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    ..These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output...
  3. ncbi Neural basis of a perceptual decision in the parietal cortex (area LIP) of the rhesus monkey
    M N Shadlen
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurophysiol 86:1916-36. 2001
    ..The time course of the neural response suggests that LIP accumulates sensory signals relevant to the selection of a target for an eye movement...
  4. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
    ..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment...
  5. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR allows either knockout of single action potentials, or sustained blockade of spiking...
  6. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  7. ncbi Neural correlations, population coding and computation
    Bruno B Averbeck
    Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Neurosci 7:358-66. 2006
    ..Here, we review studies that address the interaction between neuronal noise and population codes, and discuss their implications for population coding in general...
  8. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
    ..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies...
  9. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  10. doi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
    ..Thus, single dendritic branches can already exhibit nonuniform synaptic integration, with the computational strategy shifting from temporal coding to rate coding along the dendrite...
  11. ncbi An energy budget for signaling in the grey matter of the brain
    D Attwell
    Department of Physiology, University College London, London, UK
    J Cereb Blood Flow Metab 21:1133-45. 2001
    ..b>Action potentials and postsynaptic effects of glutamate are predicted to consume much of the energy (47% and 34%, respectively)..
  12. doi Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    Alessandra Moretti
    Cardiology Division, First Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    N Engl J Med 363:1397-409. 2010
    ..In long-QT syndrome type 1, mutations occur in the KCNQ1 gene, which encodes the repolarizing potassium channel mediating the delayed rectifier I(Ks) current...
  13. pmc Weak pairwise correlations imply strongly correlated network states in a neural population
    Elad Schneidman
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 440:1007-12. 2006
    ..As a first test for the generality of these ideas, we show that similar results are obtained from networks of cultured cortical neurons...
  14. pmc High-performance genetically targetable optical neural silencing by light-driven proton pumps
    Brian Y Chow
    The MIT Media Laboratory, Synthetic Neurobiology Group, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 463:98-102. 2010
    ..Light-driven proton pumps thus represent a high-performance and extremely versatile class of 'optogenetic' voltage and ion modulator, which will broadly enable new neuroscientific, biological, neurological and psychiatric investigations...
  15. doi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
    ..Our findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated...
  16. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
  17. ncbi Modulation of neuronal interactions through neuronal synchronization
    Thilo Womelsdorf
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands
    Science 316:1609-12. 2007
    ..These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions...
  18. pmc The normalization model of attention
    John H Reynolds
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Neuron 61:168-85. 2009
    ....
  19. pmc The asynchronous state in cortical circuits
    Alfonso Renart
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Science 327:587-90. 2010
    ..Our results suggest a reexamination of the sources underlying observed correlations and their functional consequences for information processing...
  20. ncbi Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons
    N Brunel
    LPS, Ecole Normale Superieure, Paris, France
    J Comput Neurosci 8:183-208. 2000
    ..In the slow oscillatory state, the network frequency depends mostly on the membrane time constant. Finite size effects in the asynchronous state are also discussed...
  21. ncbi Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task
    Jamie D Roitman
    Program in Neurobiology and Behavior, Department of Physiology and Biophysics, and Regional Primate Research Center, University of Washington, Seattle, Washington 98195 7290, USA
    J Neurosci 22:9475-89. 2002
    ..A threshold level of LIP activity appears to mark the completion of the decision process and to govern the tradeoff between accuracy and speed of perception...
  22. ncbi The gamma cycle
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:309-16. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  23. ncbi Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    M A Cowley
    The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    Nature 411:480-4. 2001
    ..Leptin increases the frequency of action potentials in the anorexigenic POMC neurons by two mechanisms: depolarization through a nonspecific cation channel; and ..
  24. pmc The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability
    M V Tsodyks
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 94:719-23. 1997
    ..probability of neurotransmitter release, dictates the extent to which firing rate and temporal coherence of action potentials within a presynaptic population are signaled to the postsynaptic neuron...
  25. ncbi What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance
    Nicolas Brunel
    Centre National de la Recherche Scientifique Neurophysique et Physiologie du Système Moteur Université Paris René Descartes, 75270 Paris Cedex 06, France
    J Neurophysiol 90:415-30. 2003
    ..Faster excitation than inhibition, or a higher excitation/inhibition ratio, favors the feedback loop and a much slower oscillation (typically in the gamma range)...
  26. doi Spiking activity propagation in neuronal networks: reconciling different perspectives on neural coding
    Arvind Kumar
    Bernstein Center Freiburg and Faculty of Biology, University of Freiburg, Hansastrasse 9A, 79104, Freiburg, Germany
    Nat Rev Neurosci 11:615-27. 2010
    ..Here, we review the dichotomy of asynchronous and synchronous propagation in FFNs, propose their integration into a single extended conceptual framework and suggest experimental strategies to test our hypothesis...
  27. pmc Measuring and interpreting neuronal correlations
    Marlene R Cohen
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 14:811-9. 2011
    ..Given these complicating factors, we offer guidelines for interpreting correlation data and a discussion of how best to evaluate the effect of correlations on cortical processing...
  28. doi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
    ....
  29. ncbi Sparse coding of sensory inputs
    Bruno A Olshausen
    Center for Neuroscience, UC Davis, 1544 Newton Court, Davis, California 95616, USA
    Curr Opin Neurobiol 14:481-7. 2004
    ..Recent physiological recordings from sensory neurons have indicated that sparse coding could be a ubiquitous strategy employed in several different modalities across different organisms...
  30. doi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
    ..Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation...
  31. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
    ..almost entirely for the large trial-to-trial variability of sensory-evoked postsynaptic potentials and action potentials. Subthreshold sensory synaptic responses evoked while a cortical area was spontaneously depolarized were ..
  32. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed ..
  33. pmc High-frequency, long-range coupling between prefrontal and visual cortex during attention
    Georgia G Gregoriou
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1207-10. 2009
    ....
  34. pmc Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment
    Pietro Berkes
    Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Science 331:83-7. 2011
    ..This demonstrates the progressive adaptation of internal models to the statistics of natural stimuli at the neural level...
  35. doi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution...
  36. pmc Spontaneous cortical activity in awake monkeys composed of neuronal avalanches
    Thomas Petermann
    Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:15921-6. 2009
    ..Such scale-invariance has ontogenetic and phylogenetic implications because it allows large increases in network capacity without a fundamental reorganization of the system...
  37. pmc Attractor dynamics in the hippocampal representation of the local environment
    Tom J Wills
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Science 308:873-6. 2005
    ..This enables study of attractor dynamics in a cognitive representation and may correspond to the formation of distinct contexts in context-dependent memory...
  38. ncbi Nonlinear multivariate analysis of neurophysiological signals
    Ernesto Pereda
    Department of Basic Physics, College of Physics and Mathematics, University of La Laguna, Avda Astrofísico Fco Sánchez s n, 38205 La Laguna, Tenerife, Spain
    Prog Neurobiol 77:1-37. 2005
    ..Finally, we illustrate the use of multivariate surrogate data test for the assessment of the strength (strong or weak) and the type (linear or nonlinear) of interdependence between neurophysiological signals...
  39. ncbi The action potential in mammalian central neurons
    Bruce P Bean
    Harvard Medical School, Department of Neurobiology, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 8:451-65. 2007
    ..This rich repertoire of channels allows neurons to encode information by generating action potentials with a wide range of shapes, frequencies and patterns...
  40. ncbi Large-scale recording of neuronal ensembles
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 7:446-51. 2004
    ....
  41. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    ..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
  42. pmc Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4
    Jude F Mitchell
    Systems Neurobiology Lab, The Salk Institute, La Jolla, CA 92037 1099, USA
    Neuron 63:879-88. 2009
    ..This attention-dependent reduction of ongoing cortical activity improves the signal-to-noise ratio of pooled neural signals substantially more than attention-dependent increases in firing rate...
  43. pmc An oscillatory interference model of grid cell firing
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, United Kingdom
    Hippocampus 17:801-12. 2007
    ..Predictions of the interference model are given for the frequency composition of EEG power spectra and temporal autocorrelograms of grid cell firing as functions of the speed and direction of running and the novelty of the environment...
  44. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    ..Here, we induced cardiomyocyte differentiation of hES cells by a novel method and compared their electrophysiological properties and coupling with those of primary human fetal cardiomyocytes...
  45. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  46. ncbi Real-time computing without stable states: a new framework for neural computation based on perturbations
    Wolfgang Maass
    Institute for Theoretical Computer Science, Technische Universitat Graz, A 8010 Graz, Austria
    Neural Comput 14:2531-60. 2002
    ..Our approach provides new perspectives for the interpretation of neural coding, the design of experiments and data analysis in neurophysiology, and the solution of problems in robotics and neurotechnology...
  47. doi How connectivity, background activity, and synaptic properties shape the cross-correlation between spike trains
    Srdjan Ostojic
    Institut des Systemes Complexes Paris Ile de France and Laboratoire de Physique Statistique, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Universite Paris Diderot, Ecole Normale Superieure, Paris, France
    J Neurosci 29:10234-53. 2009
    ..In particular, we show that the postsynaptic neuron spiking regularity has a pronounced influence on CCF amplitude. This suggests an efficient and flexible mechanism for modulating functional interactions...
  48. ncbi Multiple neural spike train data analysis: state-of-the-art and future challenges
    Emery N Brown
    Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
    Nat Neurosci 7:456-61. 2004
    ..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research...
  49. ncbi Spike synchronization and rate modulation differentially involved in motor cortical function
    A Riehle
    Center for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
    Science 278:1950-3. 1997
    ..of a delayed-pointing task exhibited context-dependent, rapid changes in the patterns of coincident action potentials. Accurate spike synchronization occurred in relation to external events (stimuli, movements) and was ..
  50. ncbi Developing networks play a similar melody
    Y Ben-Ari
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Cedex 09, Marseille, France
    Trends Neurosci 24:353-60. 2001
    ....
  51. doi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    ..After a nerve lesion, these mice showed no neuropathic pain in response to thermal or mechanical stimuli. Neuropathic pain is therefore initiated by HCN2-driven action potential firing in Na(V)1.8-expressing nociceptors...
  52. pmc Stimulus onset quenches neural variability: a widespread cortical phenomenon
    Mark M Churchland
    Department of Electrical Engineering, Stanford University School of Medicine, Stanford University, Stanford, California, USA
    Nat Neurosci 13:369-78. 2010
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  53. ncbi Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
    ..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience...
  54. doi Dendritic organization of sensory input to cortical neurons in vivo
    Hongbo Jia
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Nature 464:1307-12. 2010
    ..Thus, orientation-tuned neurons can compute their characteristic firing pattern by integrating spatially distributed synaptic inputs coding for multiple stimulus orientations...
  55. ncbi Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
    Jonathan Fritz
    Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Neurosci 6:1216-23. 2003
    ..Some receptive field changes persisted for hours after the task was over and hence may contribute to long-term sensory memory...
  56. ncbi Place cells, grid cells, and the brain's spatial representation system
    Edvard I Moser
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Annu Rev Neurosci 31:69-89. 2008
    ....
  57. ncbi The metabolic cost of neural information
    S B Laughlin
    Department of Zoology, University of Cambridge, UK
    Nat Neurosci 1:36-41. 1998
    ..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
  58. pmc Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop
    Kenji Mizuseki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 64:267-80. 2009
    ..We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop...
  59. ncbi Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering
    R Quian Quiroga
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, U S A
    Neural Comput 16:1661-87. 2004
    ..For these data sets, we found that the proposed algorithm outperformed conventional methods...
  60. ncbi An ultra-sparse code underlies the generation of neural sequences in a songbird
    Richard H R Hahnloser
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    Nature 419:65-70. 2002
    ....
  61. ncbi Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..responses were evoked in layer 5 PCs following stimulation of individual neighboring PCs with trains of action potentials. The probability for inhibition between PCs was more than twice that of direct excitation, and inhibitory ..
  62. ncbi A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects
    Wilson Truccolo
    Neuroscience Department, Brown University, Providence, RI, USA
    J Neurophysiol 93:1074-89. 2005
    ..The framework thus allows for the formulation and analysis of point process models of neural spiking activity that readily capture the simultaneous effects of multiple covariates and enables the assessment of their relative importance...
  63. pmc Spatio-temporal correlations and visual signalling in a complete neuronal population
    Jonathan W Pillow
    Gatsby Computational Neuroscience Unit, UCL, 17 Queen Square, London WC1N 3AR, UK
    Nature 454:995-9. 2008
    ..This model-based approach reveals the role of correlated activity in the retinal coding of visual stimuli, and provides a general framework for understanding the importance of correlated activity in populations of neurons...
  64. ncbi Neuronal coherence as a mechanism of effective corticospinal interaction
    Jan Mathijs Schoffelen
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EK Nijmegen, Netherlands
    Science 308:111-3. 2005
    ..This coherence may contribute to an effective corticospinal interaction and shortened reaction times...
  65. pmc Forward and reverse hippocampal place-cell sequences during ripples
    Kamran Diba
    Center for Molecular and Behavioral Neurobiology, Rutgers University, 197 University Ave, Newark, New Jersey 07102, USA
    Nat Neurosci 10:1241-2. 2007
    ..This bidirectional re-enactment of temporal sequences may contribute to the establishment of higher-order associations in episodic memory...
  66. ncbi KCNQ1 gain-of-function mutation in familial atrial fibrillation
    Yi Han Chen
    Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People s Republic of China
    Science 299:251-4. 2003
    ..Thus, the S140G mutation is likely to initiate and maintain AF by reducing action potential duration and effective refractory period in atrial myocytes...
  67. pmc Oscillatory phase coupling coordinates anatomically dispersed functional cell assemblies
    Ryan T Canolty
    Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:17356-61. 2010
    ..These findings suggest that neuronal oscillations enable selective and dynamic control of distributed functional cell assemblies...
  68. ncbi Distinct ensemble codes in hippocampal areas CA3 and CA1
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1295-8. 2004
    ..In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently...
  69. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..In view of the high firing rates in the functionally disconnected state of slow-wave sleep, we suggest that neocortical neurons are engaged in processing internally generated signals...
  70. ncbi Spatial representation in the entorhinal cortex
    Marianne Fyhn
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1258-64. 2004
    ....
  71. ncbi Spike timing-dependent plasticity of neural circuits
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
    Neuron 44:23-30. 2004
    ..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule...
  72. ncbi Adaptive exponential integrate-and-fire model as an effective description of neuronal activity
    Romain Brette
    Dept d Informatique, Equipe Odyssée, Ecole Normale Superieure, 45 rue d Ulm, 75230 Paris Cedex 05, France
    J Neurophysiol 94:3637-42. 2005
    ..These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro...
  73. ncbi Turning on and off recurrent balanced cortical activity
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 423:288-93. 2003
    ..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex...
  74. ncbi Correlation between neural spike trains increases with firing rate
    Jaime de la Rocha
    Center for Neural Science, New York University, New York 10003, USA
    Nature 448:802-6. 2007
    ..thalamus, and several cortical regions show temporal correlation between the discharge times of their action potentials (spike trains)...
  75. ncbi Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
    ..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience...
  76. pmc Electrophysiologic basis for the antiarrhythmic actions of ranolazine
    Charles Antzelevitch
    Masonic Medical Research Laboratory, Utica, New York, USA
    Heart Rhythm 8:1281-90. 2011
    ..This review summarizes the available data regarding the electrophysiologic actions and antiarrhythmic properties of ranolazine in preclinical and clinical studies...
  77. doi Extracting information from neuronal populations: information theory and decoding approaches
    Rodrigo Quian Quiroga
    Department of Engineering, University of Leicester, Leicester, LE1 7RH, UK
    Nat Rev Neurosci 10:173-85. 2009
    ..Such population analysis can give us more information about how neurons encode stimulus features than traditional single-cell studies...
  78. pmc Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome
    Claire A Martin
    Physiological Laboratory, University of Cambridge, Downing Site, Cambridge, United Kingdom
    J Cardiovasc Electrophysiol 21:1153-9. 2010
    ..We compared activation latencies and spatial differences in action potential recovery between different ventricular regions in a murine Scn5a+/- BrS model, and investigated the effect of flecainide and quinidine upon these...
  79. pmc Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
    Carl Holmgren
    Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
    J Physiol 551:139-53. 2003
    ..With such a high degree of connectivity with surrounding pyramidal cells, local interneurons are ideally poised to both coordinate and expand the local pyramidal cell network via pyramidal-interneuron-pyramidal communication...
  80. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
    ....
  81. ncbi Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study
    Thomas Nevian
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Nat Neurosci 10:206-14. 2007
    ..remote from the soma (>30-fold excitatory postsynaptic potential (EPSP) attenuation) and back-propagating action potentials were significantly attenuated...
  82. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
    ..These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell...
  83. ncbi Coordinated memory replay in the visual cortex and hippocampus during sleep
    Daoyun Ji
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:100-7. 2007
    ..These results imply simultaneous reactivation of coherent memory traces in the cortex and hippocampus during sleep that may contribute to or reflect the result of the memory consolidation process...
  84. ncbi Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
    Wenqin Hu
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Neurosci 12:996-1002. 2009
    ..However, it is not clear why action potentials are not initiated at the proximal AIS, which has a similarly high Na(+) channel density...
  85. pmc Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex
    Shigeyoshi Fujisawa
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 11:823-33. 2008
    ..Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets...
  86. pmc Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells
    Theofanis Karayannis
    Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom
    J Neurosci 30:9898-909. 2010
    ..Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex...
  87. pmc Lateral competition for cortical space by layer-specific horizontal circuits
    Hillel Adesnik
    Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0634, USA
    Nature 464:1155-60. 2010
    ..Through this mechanism, cortical domains exploit horizontal projections to compete for cortical space...
  88. ncbi Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
    Andrea Hasenstaub
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 47:423-35. 2005
    ..Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex...
  89. pmc Functional connectome of the striatal medium spiny neuron
    Nao Chuhma
    Department of Psychiatry and Pharmacology, Columbia University, New York, NY 10032, USA
    J Neurosci 31:1183-92. 2011
    ..This optogenetic approach defines the functional connectome of the striatal medium spiny neuron...
  90. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
    ....
  91. ncbi Stimulus dependence of neuronal correlation in primary visual cortex of the macaque
    Adam Kohn
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:3661-73. 2005
    ....
  92. doi Fragmentation of grid cell maps in a multicompartment environment
    Dori Derdikman
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway
    Nat Neurosci 12:1325-32. 2009
    ..These results indicate that spatial environments are represented in entorhinal cortex and hippocampus as a mosaic of discrete submaps that correspond to the geometric structure of the space...
  93. ncbi Sampling properties of the spectrum and coherency of sequences of action potentials
    M R Jarvis
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    Neural Comput 13:717-49. 2001
    ..Although the material discussed is of general applicability to point processes, attention will be confined to sequences of neuronal action potentials (spike trains), the motivation for this work.
  94. pmc Regulation of spike timing in visual cortical circuits
    Paul Tiesinga
    Physics and Astronomy Department, University of North Carolina at Chapel Hill, North Carolina 27599 3255, USA
    Nat Rev Neurosci 9:97-107. 2008
    A train of action potentials (a spike train) can carry information in both the average firing rate and the pattern of spikes in the train...
  95. pmc Memory and decision making in the frontal cortex during visual motion processing for smooth pursuit eye movements
    Natsuko Shichinohe
    Department of Physiology, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Neuron 62:717-32. 2009
    ..These results suggest an important role for the SEF in memory and assessment of visual motion direction and the programming of appropriate pursuit eye movements...
  96. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
    ..Our results thus indicate that A1 neurons, in addition to processing the acoustic features of sounds, may also be involved in sensory memory and novelty detection...
  97. pdf Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors
    M Victoria Puig
    Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Aichi 444 8787, Japan
    J Neurosci 30:2211-22. 2010
    ..These results may provide insight into impaired serotonergic control of network activity in psychiatric illnesses such as schizophrenia and depression...
  98. ncbi Effects of synaptic noise and filtering on the frequency response of spiking neurons
    N Brunel
    LPS, , Paris, France
    Phys Rev Lett 86:2186-9. 2001
    ..Thus, through its effect on noise inputs, realistic synaptic dynamics can ensure unlagged neuronal responses to high-frequency inputs...
  99. ncbi Evaluating causal relations in neural systems: granger causality, directed transfer function and statistical assessment of significance
    M Kaminski
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton 33431, USA
    Biol Cybern 85:145-57. 2001
    ..In addition, we propose a method to assess the significance of causality measures. Finally, we demonstrate the applications of these measures to simulated data and actual neurobiological recordings...
  100. ncbi Hemodynamic signals correlate tightly with synchronized gamma oscillations
    Jörn Niessing
    Max Planck Institute for Brain Research, 60528 Frankfurt M, Germany
    Science 309:948-51. 2005
    ..These are more closely related to local field potentials (LFPs) than to action potentials. We simultaneously recorded electrical and hemodynamic responses in the cat visual cortex...
  101. ncbi Predicting spike timing of neocortical pyramidal neurons by simple threshold models
    Renaud Jolivet
    Ecol Polytechnique Federale de Lausanne EPFL, School of Computer and Communication Sciences and Brain Mind Institute, Station 15, CH 1015, Lausanne, Switzerland
    J Comput Neurosci 21:35-49. 2006
    ....

Research Grants75

  1. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2001
    ..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
  2. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2010
    ..system, Schwann cells form the myelin sheath that wraps axons and allows for the rapid transmission of action potentials. Disruption of myelin causes peripheral neuropathies, debilitating diseases that affect 1...
  3. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2007
    ..ACTH- and All-stimulated cortisol and aldosterone secretion that depends on the generation of Ca2+-dependent action potentials. Specifically, the inhibition of bTREK-1 K+ channels by ACTH and All leads to action potentials driven by ..
  4. Hybrid Nanostructures for Wireless In Vivo Action Potential Sensing
    Joshua Goldberger; Fiscal Year: 2007
    The use of electrochemical probes for sensing the action potentials of neuron cells in vitro and in vivo has led to much of our basic understanding concerning the mechanisms of nerve cell signaling...
  5. NEURAL SUBSTRATES OF COGNITIVE DECLINE IN AGING MONKEYS
    DOUGLAS ROSENE; Fiscal Year: 2007
    ..cohorts 1 and 3, perfusion fixation will be preceded by in vivo neurophysiological assessment of compound action potentials. Then the two stage perfusion will follow to allow immediate collection of unfixed samples from one ..
  6. Bioengineering Core for Cellular and Tissue Models
    Andrew McCulloch; Fiscal Year: 2009
    ..the potentiometric dye is wavelength shifted with altered membrane potential, upright and inverted optical action potentials can be recorded at green (560 nm) and red (620 nm) wavelengths respectively...
  7. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2005
    ..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  8. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2004
    ..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  9. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  10. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2003
    ..branches, will be perfused, stained with voltage and Ca 2+ - sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca 2v(Cai) transients from 256 sites at high spatial and temporal resolution...
  11. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2010
    Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
  12. Selective targeting of sodium channel blockers to pain-sensing neurons
    BRUCE BEAN; Fiscal Year: 2009
    Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
  13. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2010
    Pain is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors...
  14. Factors that Initiate Arrhythmias in lung QT Syndrome
    Guy Salama; Fiscal Year: 2004
    ..branches, will be perfused, stained with voltage and Ca2+ sensitive dyes to simultaneously map action potentials (APs) and intracellular Ca2+ (Ca1) transients from 256 sites at high spatial and temporal resolution...
  15. RESPONSES OF HUMAN ASTROCYTES TO GP120--VIP AND ANTI-CD4
    Eric Gruenstein; Fiscal Year: 1990
    ..In addition, recent studies indicate that astrocytes are able to generate action potentials, a capability which raises the possibility of important new roles for these cells in intercellular ..
  16. Molecular Physiology of Myotonia and Periodic Paralysis
    Stephen Cannon; Fiscal Year: 2009
    ..Myotonia is a disorder of enhanced excitability wherein a single stimulus elicits a high-frequency burst of action potentials that produces involuntary persistent muscle contraction lasting seconds...
  17. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    JULIO VERGARA; Fiscal Year: 2009
    ..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the ..
  18. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2010
    ..We have found that Ca2+ release evoked by action potentials (APs) (or voltage-clamp pulses) in muscle fibers from two of such models, the adult mdx mouse and the ..
  19. NEUROTRANSMITTER ACTIONS IN NEOCORTEX AND THALAMUS
    David McCormick; Fiscal Year: 2009
    ..In-addition, information processing in the cortex depends critically upon the rate and timing of action potentials. The proposed projects will reveal the functional balance of recurrent excitation and inhibition in vivo and ..
  20. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    ..Compound action potentials (CAPs) and auditory brainstem responses (ABRs) recorded in forward and simultaneous masking paradigms will ..
  21. REGULATION OF SODIUM CHANNEL EXPRESSION
    ROBERT MAUE; Fiscal Year: 2000
    ..tightly controlled expression of Na channels is critical to the ability of neurons to generate and propagate action potentials, and as such is central to information transfer in the nervous system...
  22. Spontaneous activity in the developing cochlea
    Dwight Bergles; Fiscal Year: 2009
    ..In the developing cochlea, bursts of action potentials occur in afferent spiral ganglion neurons prior to the onset of hearing, activity that has been traced to ..
  23. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..In the developing cochlea, bursts of action potentials occur in afferent spiral ganglion neurons prior to the onset of hearing, activity that has been traced to ..
  24. REGULATION OF SODIUM CHANNEL EXPRESSION
    ROBERT MAUE; Fiscal Year: 1999
    ..tightly controlled expression of Na channels is critical to the ability of neurons to generate and propagate action potentials, and as such is central to information transfer in the nervous system...
  25. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..release of LT by a TK supports the model of a "relay mediator" role for LTs in which they trigger antidromic action potentials or directly produce Ca+ mediated TK release; TKs, in turn, cause further LT release and the cascading spread ..
  26. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1990
    ..release of LT by a TK supports the model of a "relay mediator" role for LTs in which they trigger antidromic action potentials or directly produce Ca+ mediated TK release; TKs, in turn, cause further LT release and the cascading spread ..
  27. Mechanisms of Alcohol Withdrawal
    DWAYNE GODWIN; Fiscal Year: 2009
    ..seizure is an abnormal brain rhythm that is produced in the thalamus by neurons firing rhythmic bursts of action potentials. These bursts depend upon a class of T-type calcium channels that are expressed within the brain and ..
  28. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2002
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  29. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2001
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  30. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2003
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  31. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 2000
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  32. GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITY
    Leon Avery; Fiscal Year: 1999
    ..3) One or more ion channels are specifically necessary for myogenic triggering of action potentials. (4) The activity of the myogenic system is regulated by a muscarinic acetylcholine receptor...
  33. REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 1999
    ..Basolateral ionic currents in dissociated cells (supporting and hair cells) and action potentials on primary afferents will be studied in vitro and in vivo, respectively...
  34. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2005
    ..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
  35. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2004
    ..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
  36. STRUCTURE/FUNCTION OF THE PACEMAKING AND CONDUCTION SYSTEM OF THE HEART
    Igor R Efimov; Fiscal Year: 2010
    ..complex structure orchestrating orderly contractions of the cardiac chambers by generating and transmitting action potentials at an appropriate rate, conduction velocity, and incorporating a delay between the chambers to allow for ..
  37. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2003
    ..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
  38. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2002
    ..Preliminary electrophysiological experiments indicate that sling cells have excitable membranes and fire action potentials in response to long depolarizing pulses via whole-cell current clamp...
  39. STRUCTURE/FUNCTION OF THE PACEMAKING AND CONDUCTION SYSTEM OF THE HEART
    Igor Efimov; Fiscal Year: 2009
    ..complex structure orchestrating orderly contractions of the cardiac chambers by generating and transmitting action potentials at an appropriate rate, conduction velocity, and incorporating a delay between the chambers to allow for ..
  40. High Resolution 3D Optics Coherence Phase Microscopy
    Johannes F de Boer; Fiscal Year: 2010
    ..imaging (250 [unreadable]m) and the exploitation of phase sensitivity will be investigated by monitoring action potentials in axons embedded in larger nerve bundles...
  41. Molecular Physiology of Myotonia and Periodic Paralysis
    Stephen Cannon; Fiscal Year: 2009
    ..Myotonia is a disorder of enhanced excitability wherein a single stimulus elicits a high- frequency burst of action potentials that produces involuntary persistent muscle contraction lasting seconds...
  42. Molecular Physiology of Myotonia and Periodic Paralysis
    Stephen C Cannon; Fiscal Year: 2010
    ..Myotonia is a disorder of enhanced excitability wherein a single stimulus elicits a high- frequency burst of action potentials that produces involuntary persistent muscle contraction lasting seconds...
  43. High Resolution 3D Optics Coherence Phase Microscopy
    Johannes De Boer; Fiscal Year: 2009
    ..imaging (250 [unreadable]m) and the exploitation of phase sensitivity will be investigated by monitoring action potentials in axons embedded in larger nerve bundles...
  44. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2005
    ..ACTH- and All-stimulated cortisol and aldosterone secretion that depends on the generation of Ca2+-dependent action potentials. Specifically, the inhibition of bTREK-1 K+ channels by ACTH and All leads to action potentials driven by ..
  45. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2006
    ..ACTH- and All-stimulated cortisol and aldosterone secretion that depends on the generation of Ca2+-dependent action potentials. Specifically, the inhibition of bTREK-1 K+ channels by ACTH and All leads to action potentials driven by ..
  46. Properties of Ion Channels that Control Secretion
    JOHN ENYEART; Fiscal Year: 2004
    ..ACTH- and All-stimulated cortisol and aldosterone secretion that depends on the generation of Ca2+-dependent action potentials. Specifically, the inhibition of bTREK-1 K+ channels by ACTH and All leads to action potentials driven by ..
  47. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..polymer, polyethylene glycol (PEG), the investigators have successfully restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  48. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2002
    ..polymer, polyethylene glycol (PEG), the investigators have successfully restored the conduction of compound action potentials (CAP) in severed guinea pig spinal cord and peripheral nerves in vitro...
  49. Genetic mechanisms of myelination in zebrafish
    William S Talbot; Fiscal Year: 2012
    ..system, Schwann cells form the myelin sheath that wraps axons and allows for the rapid transmission of action potentials. Disruption of myelin causes peripheral neuropathies, debilitating diseases that affect 1...
  50. Genetic mechanisms of myelination in zebrafish
    WILLIAM TALBOT; Fiscal Year: 2009
    ..system, Schwann cells form the myelin sheath that wraps axons and allows for the rapid transmission of action potentials. Disruption of myelin causes peripheral neuropathies, debilitating diseases that affect 1...
  51. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording ..
  52. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2000
    ..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
  53. Afterhyperpolarization in dopamine neurons, H2O2 and KATP channels
    Marat Avshalumov; Fiscal Year: 2009
    ..pattern is the prolonged afterhyperpolarization (AHP) that follows a single action potential or burst of action potentials. In DA neurons the AHP contributes to the regulation of the frequency and pattern of spontaneous and evoked ..
  54. Afterhyperpolarization in dopamine neurons, H2O2 and KATP channels
    Margaret Rice; Fiscal Year: 2009
    ..pattern is the prolonged afterhyperpolarization (AHP) that follows a single action potential or burst of action potentials. In DA neurons the AHP contributes to the regulation of the frequency and pattern of spontaneous and evoked ..
  55. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2000
    ..In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording ..
  56. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 2000
    ..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
  57. SK CHANNELS IN HYPEREXCITABLE SKELETAL MUSCLE
    John Adelman; Fiscal Year: 1999
    ..DM), or myotubes cultured in the absence of nerve, skeletal muscle is hyperexcitable, in that a train of action potentials is often induced following an evoked contraction...
  58. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2001
    ..In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording ..
  59. Hybrid Nanostructures for Wireless In Vivo Action Potential Sensing
    Joshua Goldberger; Fiscal Year: 2009
    The use of electrochemical probes for sensing the action potentials of neuron cells in vitro and in vivo has led to much of our basic understanding concerning the mechanisms of nerve cell signaling...
  60. Characterization of Evoked Potentials During Deep Brain Stimulation
    ALEXANDER RAFAEL KENT; Fiscal Year: 2010
    ..The overall aim of this project is to measure and characterize the electrically evoked compound action potentials (ECAPs) generated by activated neurons near the DBS electrode...
  61. Modulation of cardiac K+ channels by drugs
    Michael Sanguinetti; Fiscal Year: 2001
    Drugs that block the rapid delayed rectifier K+ current (Ikr) cause prolongation of cardiac action potentials and electrical refractoriness...
  62. Neurogenic Calcium Signals in Small Arteries
    WITHROW WIER; Fiscal Year: 2005
    ..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...
  63. Modulation of cardiac K+ channels by drugs
    Michael Sanguinetti; Fiscal Year: 2002
    Drugs that block the rapid delayed rectifier K+ current (Ikr) cause prolongation of cardiac action potentials and electrical refractoriness...
  64. Modulation of cardiac K+ channels by drugs
    Michael Sanguinetti; Fiscal Year: 2003
    Drugs that block the rapid delayed rectifier K+ current (Ikr) cause prolongation of cardiac action potentials and electrical refractoriness...
  65. Neurogenic Calcium Signals in Small Arteries
    WITHROW WIER; Fiscal Year: 2004
    ..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...
  66. Modulation of cardiac K+ channels by drugs
    Michael Sanguinetti; Fiscal Year: 2004
    Drugs that block the rapid delayed rectifier K+ current (Ikr) cause prolongation of cardiac action potentials and electrical refractoriness...
  67. Neurogenic Calcium Signals in Small Arteries
    WITHROW WIER; Fiscal Year: 2007
    ..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...
  68. Neurogenic Calcium Signals in Small Arteries
    WITHROW WIER; Fiscal Year: 2006
    ..With higher frequency stimulation, Ca 2+ 'flashes' (may be due to SMC action potentials) and Ca 2+waves are generated...
  69. NEURAL SUBSTRATES OF COGNITIVE DECLINE IN AGING MONKEYS
    DOUGLAS ROSENE; Fiscal Year: 2009
    ..cohorts 1 and 3, perfusion fixation will be preceded by in vivo neurophysiological assessment of compound action potentials. Then the two stage perfusion will follow to allow immediate collection of unfixed samples from one ..
  70. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2004
    ..We have developed optical imaging techniques to map detrusor action potentials and Ca 2+ fluxes...