excitatory postsynaptic potentials

Summary

Summary: The change in potential produced in the membrane of the next neuron when an impulse which has an excitatory influence arrives at the synapse; it is a local change in the direction of depolarization; summation of these potentials can lead to discharge of an impulse by the neuron. (Stedman, 26th ed)

Top Publications

  1. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
  2. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
  3. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  4. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
  5. ncbi Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
  6. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
  7. ncbi Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
    M A Ungless
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    Nature 411:583-7. 2001
  8. ncbi A synaptic memory trace for cortical receptive field plasticity
    Robert C Froemke
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA
    Nature 450:425-9. 2007
  9. ncbi Adaptation to synaptic inactivity in hippocampal neurons
    Tara C Thiagarajan
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Neuron 47:725-37. 2005
  10. pmc Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
    M Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences, and The Graduate University for Advanced Studies, Myodaiji, Okazaki 444-8585, Japan
    Nat Neurosci 4:1086-92. 2001

Research Grants

  1. Stress, Depression, Serotonin, and Plasticity of Excitatory Transmission
    Scott M Thompson; Fiscal Year: 2013
  2. Molecular Physiology of the SK2 Channels in CA1 Neurons
    John P Adelman; Fiscal Year: 2013
  3. Role of Doc2 in calcium regulation of synapses
    Taulant Bacaj; Fiscal Year: 2012
  4. The Role of Heterosynaptic Plasticity in Achieving Stable Yet Adaptable Memory
    Maxim Volgushev; Fiscal Year: 2013
  5. EtOH Modulation of Synaptic Plasticity in Nucleus Accumbens
    Gilles E Martin; Fiscal Year: 2013
  6. Diversity of Nicotinic Synapses in Sympathetic Ganglia
    John Horn; Fiscal Year: 2004
  7. Acetylcholine in Diabetic Enteric Nervous System
    KATHY LEPARD; Fiscal Year: 2004
  8. SEROTONIN MODULATION OF NEUROTRANSMISSION IN NEOCORTEX
    Gerard Marek; Fiscal Year: 2001
  9. Activity Dependent Modulation of SK2 Channels
    Mike Lin; Fiscal Year: 2009
  10. Mechanisms of Fast Synaptic Facilitation in Colitis
    Eric Krauter; Fiscal Year: 2007

Detail Information

Publications312 found, 100 shown here

  1. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
    ....
  2. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
    ..Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation...
  3. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  4. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  5. ncbi Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Camilla Bellone
    Department of Basic Neurosciences, University of Geneva, 1 Michel Servet, CH 1211 Geneva, Switzerland
    Nat Neurosci 9:636-41. 2006
    ....
  6. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
    ....
  7. ncbi Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
    M A Ungless
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, California 94110, USA
    Nature 411:583-7. 2001
    ..These results show that a prominent form of synaptic plasticity can be elicited by a single in vivo exposure to cocaine and therefore may be involved in the early stages of the development of drug addiction...
  8. ncbi A synaptic memory trace for cortical receptive field plasticity
    Robert C Froemke
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA
    Nature 450:425-9. 2007
    ..This restricted period of disinhibition may be a fundamental mechanism for receptive field plasticity, and could serve as a memory trace for stimuli or episodes that have acquired new behavioural significance...
  9. ncbi Adaptation to synaptic inactivity in hippocampal neurons
    Tara C Thiagarajan
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Neuron 47:725-37. 2005
    ..These results extend beyond "synaptic homeostasis" to involve more profound changes that can be better described as "metaplasticity"...
  10. pmc Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
    M Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences, and The Graduate University for Advanced Studies, Myodaiji, Okazaki 444-8585, Japan
    Nat Neurosci 4:1086-92. 2001
    ..Our data indicate that distribution of functional AMPA receptors is tightly correlated with spine geometry and that receptor activity is independently regulated at the level of single spines...
  11. ncbi NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
    Andres Barria
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Neuron 48:289-301. 2005
    ..The switch from NR2B to NR2A content in synaptic NMDA-Rs normally observed in many brain regions may contribute to reduced plasticity by controlling the binding of active CaMKII...
  12. ncbi Shunting inhibition modulates neuronal gain during synaptic excitation
    Simon J Mitchell
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 38:433-45. 2003
    ..Our results suggest that shunting inhibition can multiplicatively scale rate-coded information in neurons with high-variability synaptic inputs...
  13. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998
    ..Overall, Ih acts to dampen dendritic excitability, but its largest impact is on the subthreshold range of membrane potentials where the integration of inhibitory and excitatory synaptic inputs takes place...
  14. pmc Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  15. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    ..PICs may further induce long-term synaptic plasticity through CREB-mediated gene transcription. Blockade of PIC signaling could be an effective way to suppress central sensitization and alleviate chronic pain...
  16. pmc Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
    Wei Lu
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:254-68. 2009
    ..This study provides a functional quantification of the subunit composition of AMPARs in the CNS and suggests novel roles for AMPAR subunits in receptor trafficking...
  17. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    ....
  18. ncbi Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
    L Chen
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 408:936-43. 2000
    ....
  19. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  20. ncbi Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    Daniel Saal
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 37:577-82. 2003
    ....
  21. ncbi Potentiation of cortical inhibition by visual deprivation
    Arianna Maffei
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 443:81-4. 2006
    ....
  22. ncbi Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice
    Agnes Gruart
    Division de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    J Neurosci 26:1077-87. 2006
    ..Our results provide evidence of a relationship between activity-dependent synaptic plasticity and associative learning in behaving mice...
  23. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
  24. ncbi Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, The Biomedical Center F10, Tornavagen 10, SE 221 84, Sweden
    Neuron 34:797-806. 2002
    ..These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons...
  25. ncbi Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology
    Piotr Michaluk
    Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02 093 Warsaw, Poland
    J Cell Sci 124:3369-80. 2011
    ..Our results, considered together with several recent studies, strongly imply that MMP-9 is functionally involved in synaptic remodelling...
  26. ncbi Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
    ..These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons...
  27. ncbi Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior
    Elke C Fuchs
    Department of Clinical Neurobiology, University Hospital of Neurology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 53:591-604. 2007
    ..These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory...
  28. ncbi Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion
    Xuelin Lou
    AG Synaptische Dynamik und Modulation und Abt Membranbiophysik, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077 Gottingen, Germany
    Nature 435:497-501. 2005
    ..Our data indicate that spontaneous transmitter release close to resting [Ca2+]i is a consequence of an intrinsic property of the molecular machinery that mediates synaptic vesicle fusion...
  29. ncbi The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development
    Karl G Johnson
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 49:517-31. 2006
    ....
  30. ncbi alpha- and betaCaMKII. Inverse regulation by neuronal activity and opposing effects on synaptic strength
    Tara C Thiagarajan
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 36:1103-14. 2002
    ..Regulation of CaMKII subunit composition may be important for both activity-dependent synaptic homeostasis and plasticity...
  31. ncbi Maturation of EPSCs and intrinsic membrane properties enhances precision at a cerebellar synapse
    Laurence Cathala
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:6074-85. 2003
    ..We suggest that these concurrent developmental changes, which increase the temporal precision of EPSP-spike coupling, will increase the fidelity with which sensory information is processed within the input layer of the cerebellar cortex...
  32. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    ..This model integrates known signal transduction pathways of hyperalgesia without contradiction...
  33. ncbi A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit
    Masahiro Mori
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 431:453-6. 2004
    ..This ability to immediately switch the polarity of synaptic responses constitutes a novel synaptic mechanism, which might be crucial to the state-dependent processing of information in associative hippocampal networks...
  34. ncbi Control of synapse number by glia
    E M Ullian
    Stanford University School of Medicine, Department of Neurobiology, Fairchild Science Building, Stanford, CA 94305 5125, USA
    Science 291:657-61. 2001
    ....
  35. pmc Astrocytic control of synaptic NMDA receptors
    C Justin Lee
    Center for Neural Science, Division of Life Sciences, Korea Institute of Science and Technology, Seoul, Korea
    J Physiol 581:1057-81. 2007
    ..These results suggest that astrocytic G-protein coupled receptors that increase intracellular Ca2+ can tune synaptic NMDA receptor responses...
  36. pmc Laminar specificity of functional input to distinct types of inhibitory cortical neurons
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:70-85. 2009
    ....
  37. ncbi Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens
    Said Kourrich
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:7921-8. 2007
    ..These enduring modifications in AMPAR-mediated responses and plasticity may provide a neural substrate for disrupted processing of drug-related stimuli in drug-experienced individuals...
  38. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
  39. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    ..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
  40. ncbi Pathway-specific trafficking of native AMPARs by in vivo experience
    Roger L Clem
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Neuron 49:663-70. 2006
    ..These data demonstrate that pathway-specific trafficking of GluR2-lacking AMPARs is a normal feature of synaptic strengthening that underlies experience-dependent plasticity in the behaving animal...
  41. ncbi Neuronal activity regulates diffusion across the neck of dendritic spines
    Brenda L Bloodgood
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Science 310:866-9. 2005
    ..The regulation of diffusional coupling provides a possible mechanism for determining the amplitude of postsynaptic potentials and the accumulation of plasticity-inducing molecules within the spine head...
  42. pmc Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...
  43. ncbi SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines
    Thu Jennifer Ngo-Anh
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Neurosci 8:642-9. 2005
    ..Thus, blocking SK channels facilitates the induction of long-term potentiation by enhancing NMDAR-dependent Ca(2+) signals within dendritic spines...
  44. ncbi Internalization of ionotropic glutamate receptors in response to mGluR activation
    E M Snyder
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 4:1079-85. 2001
    ..These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking...
  45. ncbi Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse
    Nobutake Hosoi
    Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 63:216-29. 2009
    ..Rather, we postulate that perturbation of a step linking exocytosis and endocytosis temporarily prevents new vesicles from docking at specialized sites for exocytosis...
  46. pmc PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors
    Yudong Yao
    The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
    J Neurosci 28:7820-7. 2008
    ..Thus, PKMzeta maintains late-LTP by persistently modifying NSF/GluR2-dependent AMPAR trafficking to favor receptor insertion into postsynaptic sites...
  47. ncbi Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks
    Jakob von Engelhardt
    Department of Clinical Neurobiology, University of Heidelberg, D 69120 Heidelberg, Germany
    Neuron 60:846-60. 2008
    ..Thus, both hippocampal and extra-hippocampal NR2B containing NMDA receptors critically contribute to spatial performance...
  48. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible...
  49. pmc Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development
    Yujiao J Sun
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nature 465:927-31. 2010
    ..Our results suggest that functional refinement of cortical TRFs does not require a selective pruning of inputs, but may depend more on a fine adjustment of excitatory input strengths...
  50. pmc Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling
    Thomas Frank
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Göttingen Medical Center, 37099 Gottingen, Germany
    Neuron 68:724-38. 2010
    ..We conclude that Bassoon and the ribbon (1) create a large number of release sites by organizing Ca²+ channels and vesicles, and (2) promote vesicle replenishment...
  51. ncbi Tone-evoked excitatory and inhibitory synaptic conductances of primary auditory cortex neurons
    Andrew Y Y Tan
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    J Neurophysiol 92:630-43. 2004
    ..Our data indicate that the interaction of synaptic excitation and inhibition shapes the time course and frequency tuning of the spike responses of AI neurons...
  52. pmc Plastic modifications induced by object recognition memory processing
    Julia Rosauro Clarke
    Centro de Memoria, Instituto de Pesquisas Biomédicas, Pontificia Universidade Catolica do Rio Grande do Sul, 90610 000 Porto Alegre, Rio Grande do Sul, Brazil
    Proc Natl Acad Sci U S A 107:2652-7. 2010
    ..The late synaptic enhancement phase, on the other hand, would be a consequence of memory restabilization...
  53. pmc Multiple modes of network homeostasis in visual cortical layer 2/3
    Arianna Maffei
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 28:4377-84. 2008
    ..The existence of multiple, partially redundant forms of homeostatic plasticity may ensure that network compensation can be achieved in response to a wide range of sensory perturbations...
  54. ncbi Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study
    Thomas Nevian
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Nat Neurosci 10:206-14. 2007
    ....
  55. ncbi Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
    ..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...
  56. ncbi Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
    Colin J Akerman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:5117-30. 2006
    ..Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit...
  57. ncbi Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
    Christopher J Hatton
    Laboratoire de Neurobiologie, CNRS UMR 8544, Ecole Normale Supérueure, Paris, France
    Neuron 46:261-74. 2005
    ..Similarly, NR1/2A/2C receptors are inhibited by zinc with high potency but low efficacy. Therefore, interactions between homologous N-terminal domains determine the unique pharmacological properties of triheteromeric NMDARs...
  58. ncbi Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons
    Heng Ye Man
    Brain and Behavior Program and Department of Pathology, Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Neuron 38:611-24. 2003
    ....
  59. ncbi Dendritic integration in hippocampal dentate granule cells
    Roland Krueppel
    Laboratory for Cognition Research and Experimental Epileptology, Department of Epileptology, University of Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Neuron 71:512-28. 2011
    ....
  60. pmc Distinct FGFs promote differentiation of excitatory and inhibitory synapses
    Akiko Terauchi
    Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Nature 465:783-7. 2010
    ..These results demonstrate that specific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain...
  61. ncbi Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex
    Y Zilberter
    Abteilung Zellphysiologie, Max Plank Institut für Medizinische Forschung, Heidelberg, Federal Republic of Germany
    Neuron 24:979-88. 1999
    ..bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer...
  62. pmc Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release
    Alexander J Groffen
    Department of Functional Genomics, CNCR, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam, 1081 HV, Netherlands
    Science 327:1614-8. 2010
    ....
  63. ncbi SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala
    E S Louise Faber
    The Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
    Nat Neurosci 8:635-41. 2005
    ..Calcium influx through NMDARs activates SK channels and shunts the resultant excitatory postsynaptic potential. These results demonstrate a new role for SK channels as postsynaptic regulators of synaptic efficacy...
  64. pmc Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors
    Sang Yong Jung
    Department of Life Science, Pohang University of Science and Technology, Pohang, Gyungbuk 790 784, Korea
    Proc Natl Acad Sci U S A 107:4710-5. 2010
    ..These findings suggest that neuroligin-1 can modulate, in a pathway-specific manner, synaptic plasticity in the amygdala circuits of adult animals, likely by regulating the abundance of postsynaptic NMDA receptors...
  65. ncbi Turning on and off recurrent balanced cortical activity
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 423:288-93. 2003
    ..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex...
  66. ncbi Excitatory actions of gaba during development: the nature of the nurture
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, INSERM Unit 29, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    Nat Rev Neurosci 3:728-39. 2002
    ..As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks...
  67. ncbi Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization
    Asa Grunditz
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Neurosci 28:13457-66. 2008
    ..We conclude that calcium influx into spines, a key trigger for synaptic plasticity, is dynamically regulated by spine neck plasticity through a process of electrical compartmentalization...
  68. ncbi Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines
    Brenda L Bloodgood
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 53:249-60. 2007
    ..we use 2-photon glutamate uncaging to stimulate individual spines while monitoring uncaging-evoked excitatory postsynaptic potentials (uEPSPs) and Ca transients...
  69. pmc Synaptic depression enables neuronal gain control
    Jason S Rothman
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 457:1015-8. 2009
    ..Our results establish that neurons receiving depressing excitatory inputs can act as powerful multiplicative devices even when integration of postsynaptic conductances is linear...
  70. ncbi Synaptic currents in anatomically identified CA3 neurons during hippocampal gamma oscillations in vitro
    Iris Oren
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 26:9923-34. 2006
    ..The data support a recurrent mechanism of gamma oscillations, whereby spike timing is controlled primarily by inhibition in pyramidal cells and by excitation in interneurons...
  71. ncbi Interneuron diversity series: containing the detonation--feedforward inhibition in the CA3 hippocampus
    J Josh Lawrence
    Laboratory on Cellular and Synaptic Physiology, Building 49, Room 5A72, NICHD LCSN, Bethesda, MD 20892, USA
    Trends Neurosci 26:631-40. 2003
    ..Under pathological conditions where feedforward inhibition is compromised, focal excitation is no longer contained, rendering the circuit susceptible to hyperexcitability...
  72. ncbi Spike-timing-dependent plasticity of inhibitory synapses in the entorhinal cortex
    Julie S Haas
    Institute for Nonlinear Science, University of California San Diego, 9500 Gilman Dr MC0402, La Jolla, CA 92093 0402, USA
    J Neurophysiol 96:3305-13. 2006
    ..Using network models, we demonstrate how this novel form of plasticity can sculpt network behavior efficiently and with remarkable flexibility...
  73. ncbi Changes in synaptic structure underlie the developmental speeding of AMPA receptor-mediated EPSCs
    Laurence Cathala
    1 Department of Pharmacology, University College London, UK
    Nat Neurosci 8:1310-8. 2005
    ..Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission...
  74. ncbi Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition
    N Brunel
    LPS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
    J Comput Neurosci 11:63-85. 2001
    ..The present study therefore points to several mechanisms that enhance the signal-to-noise ratio in working memory states. These mechanisms could be implemented in the prefrontal cortex by dopaminergic projections from the midbrain...
  75. pmc Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation
    Jimok Kim
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA
    Neuron 58:925-37. 2008
    ..Thus, synapse-specific adaptations of synaptic weight not only contributed to homeostatic gain control, but also dampened epileptogenic network activity...
  76. pmc Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons
    Mark A Smith
    Neuroscience Center, LSUHSC, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Physiol 548:245-58. 2003
    ..We conclude, therefore, that the main synaptic mechanism involved in the production of distance-dependent scaling of Schaffer collateral synapses is an elevated postsynaptic AMPA receptor density...
  77. pmc Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
    Qingming Hou
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:775-80. 2008
    ..These results demonstrate the existence of synaptic specificity and the crucial role of AMPAR-gated calcium in homeostatic plasticity in central neurons...
  78. ncbi Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex
    Roger L Clem
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Science 319:101-4. 2008
    ....
  79. ncbi Vesicle pools and short-term synaptic depression: lessons from a large synapse
    Ralf Schneggenburger
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg, D 37077 Gottingen, Germany
    Trends Neurosci 25:206-12. 2002
    ..By influencing the synaptic output during repetitive activity, vesicle pool dynamics are expected to modulate information processing in neuronal networks of the CNS...
  80. pmc Silent synapses and the emergence of a postsynaptic mechanism for LTP
    Geoffrey A Kerchner
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94143 2140, USA
    Nat Rev Neurosci 9:813-25. 2008
    ..Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity...
  81. pmc Dendritic HCN channels shape excitatory postsynaptic potentials at the inner hair cell afferent synapse in the mammalian cochlea
    Eunyoung Yi
    The Johns Hopkins School of Medicine, Department of Otolaryngology Head and Neck Surgery, Baltimore, MD 21205, USA
    J Neurophysiol 103:2532-43. 2010
    ..b>Excitatory postsynaptic potentials (EPSPs) of variable amplitude (1-35 mV) were found with 10-90% rise times of about 1 ms and time ..
  82. ncbi Conservation of total synaptic weight through balanced synaptic depression and potentiation
    Sebastien Royer
    Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, New Jersey 07102, USA
    Nature 422:518-22. 2003
    ..Thus, in intercalated neurons at least, inverse heterosynaptic plasticity tends to compensate for homosynaptic long-term potentiation and depression, thus stabilizing total synaptic weight...
  83. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
    ..Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1...
  84. ncbi Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse
    Joern R Steinert
    MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester LE1 9HN, UK
    Neuron 60:642-56. 2008
    ....
  85. pmc Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits
    Aundrea F Bartley
    University of Texas, Southwestern Medical Center, Department of Neuroscience, Box 9111, Dallas, TX 75390 9111, USA
    J Neurophysiol 100:1983-94. 2008
    ..In summary, these results reveal that inhibitory circuitry is not uniformly regulated by activity levels and may provide insight into the mechanisms of both normal and pathological neocortical plasticity...
  86. ncbi Coordinated multivesicular release at a mammalian ribbon synapse
    Joshua H Singer
    Synaptic Physiology Unit, NIH NINDS, 36 Convent Drive, MSC 4066, Building 36 Room 2C 09, Bethesda, Maryland 20892, USA
    Nat Neurosci 7:826-33. 2004
    ..The release synchrony reflected in these multivesicular events suggests that release within an active zone is coordinated during MVR...
  87. ncbi Timing and specificity of feed-forward inhibition within the LGN
    Dawn M Blitz
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 45:917-28. 2005
    ..In contrast, dynamic-clamp recordings suggest that locked inhibition improves the precision of synaptically evoked responses in individual TC neurons by eliminating secondary spikes...
  88. pmc Facilitating pyramid to horizontal oriens-alveus interneurone inputs: dual intracellular recordings in slices of rat hippocampus
    A B Ali
    Department of Physiology, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK
    J Physiol 507:185-99. 1998
    ..3. Excitatory postsynaptic potentials (EPSPs) elicited by single pyramidal cells were 0 to 12 mV in amplitude...
  89. pmc Light-evoked synaptic activity of retinal ganglion and amacrine cells is regulated in developing mouse retina
    Quanhua He
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA
    Eur J Neurosci 33:36-48. 2011
    ..Therefore, we concluded that the synaptic mechanisms mediating spontaneous and light-evoked synaptic activity of RGCs and amacrine cells are likely to be different...
  90. ncbi Reluctant vesicles contribute to the total readily releasable pool in glutamatergic hippocampal neurons
    Krista L Moulder
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:3842-50. 2005
    ..These data suggest that glutamatergic hippocampal neurons maintain a heterogeneous population of vesicles that can be differentially released with varying Ca2+ influx, thereby increasing the range of potential synaptic responses...
  91. ncbi Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling
    Antonieta Lavin
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 25:5013-23. 2005
    ....
  92. pmc Gap junctions compensate for sublinear dendritic integration in an inhibitory network
    Koen Vervaeke
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Science 335:1624-8. 2012
    ..Our results suggest that dendritic gap junctions counteract sublinear dendritic integration by enabling excitatory synaptic charge to spread into the dendrites of neighboring inhibitory interneurons...
  93. pmc Channel properties reveal differential expression of TARPed and TARPless AMPARs in stargazer neurons
    Cecile Bats
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 15:853-61. 2012
    ....
  94. ncbi GABAergic inhibition regulates developmental synapse elimination in the cerebellum
    Hisako Nakayama
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 74:384-96. 2012
    ....
  95. pmc Different adaptations in AMPA receptor transmission in the nucleus accumbens after short vs long access cocaine self-administration regimens
    Anthony Purgianto
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA
    Neuropsychopharmacology 38:1789-97. 2013
    ..Together with data on cocaine infusions in each group, our results show that CP-AMPAR accumulation and enhanced glutamate transmission is associated with longer sessions (6 h), rather than the number of sessions or cocaine infusions...
  96. ncbi Synaptic integration in dendritic trees
    Allan T Gulledge
    Division of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra
    J Neurobiol 64:75-90. 2005
    ..This review explores the way active and passive dendritic properties shape synaptic responses in the dendrites of central neurons, and emphasizes their role in synaptic integration...
  97. pmc Long-term depression at parallel fiber to Golgi cell synapses
    Quinten Robberechts
    Theoretical Neurobiology, Dept of Biomedical Sciences, Campus Drie Eiken T5 37, Univ of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium
    J Neurophysiol 104:3413-23. 2010
    ..Furthermore, LTD induction was not dependent on activation of NMDA receptors. PF-GoC LTD does require activation of specifically group II metabotropic glutamate receptors and of protein kinase A...
  98. pmc Molecular layer inhibitory interneurons provide feedforward and lateral inhibition in the dorsal cochlear nucleus
    Michael T Roberts
    Vollum Institute and Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurophysiol 104:2462-73. 2010
    ..These synaptic relationships suggest that the set of parallel fibers activated by a particular sensory stimulus determines whether cartwheel cells provide feedforward or lateral inhibition to their postsynaptic targets...
  99. pmc Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis
    C Andrew Frank
    Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158, USA
    Neuron 52:663-77. 2006
    ..1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system...
  100. ncbi Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
    ....
  101. ncbi Computational subunits in thin dendrites of pyramidal cells
    Alon Polsky
    Department of Physiology, Technion Medical School, Bat Galim, Haifa 31096, Israel
    Nat Neurosci 7:621-7. 2004
    ..Our findings could have important implications for the computing and memory-related functions of cortical tissue...

Research Grants62

  1. Stress, Depression, Serotonin, and Plasticity of Excitatory Transmission
    Scott M Thompson; Fiscal Year: 2013
    ..PRELIMINARY RESULTS: activation of 5-HT1B receptors potentiates excitatory postsynaptic potentials (field EPSPs and EPSPs) elicited by TA stimulation in CA1 SLM, but not by Schaffer collateral ..
  2. Molecular Physiology of the SK2 Channels in CA1 Neurons
    John P Adelman; Fiscal Year: 2013
    ..conductance Ca-activated K channels (SK channels) affect excitability and contribute to shaping excitatory postsynaptic potentials (EPSPs)...
  3. Role of Doc2 in calcium regulation of synapses
    Taulant Bacaj; Fiscal Year: 2012
    ..aim will asses basal transmission in shRNA-treated cultures by measuring evoked inhibitory and excitatory postsynaptic potentials (IPSCs and EPSCs) and spontaneous miniature ISPCs...
  4. The Role of Heterosynaptic Plasticity in Achieving Stable Yet Adaptable Memory
    Maxim Volgushev; Fiscal Year: 2013
    ..Our proposal is aimed at this question. Using in vitro slices of rodent neocortex, we will record excitatory postsynaptic potentials in major types of neocortical neurons: pyramids from layer 2/3 and 5, spiny cells from layer 4 and ..
  5. EtOH Modulation of Synaptic Plasticity in Nucleus Accumbens
    Gilles E Martin; Fiscal Year: 2013
    ..Spike-Timing-Dependent Plasticity (STDP) that relies on pairing of action potentials (APs) and excitatory postsynaptic potentials (EPSP) at in vivo-like frequencies (~ 1Hz)...
  6. Diversity of Nicotinic Synapses in Sympathetic Ganglia
    John Horn; Fiscal Year: 2004
    ..distinct combinations of nicotinic receptor subunits, as a means for regulating the duration of fast excitatory postsynaptic potentials and thereby controlling the synaptic amplification of preganglionic activity...
  7. Acetylcholine in Diabetic Enteric Nervous System
    KATHY LEPARD; Fiscal Year: 2004
    ..Cholinergic and purinergic fast excitatory postsynaptic potentials will be recorded from myenteric neurons...
  8. SEROTONIN MODULATION OF NEUROTRANSMISSION IN NEOCORTEX
    Gerard Marek; Fiscal Year: 2001
    ..effect of 5-HT2A receptor activation in the neocortex is an increase in the frequency of excitatory postsynaptic potentials/currents (EPSCs/EPSCs) that is mediated by a presynaptic action of 5-HT2A receptor activation upon ..
  9. Activity Dependent Modulation of SK2 Channels
    Mike Lin; Fiscal Year: 2009
    ..N-methyl-D-aspartate receptors (NMDAr) in CA1 spines such that their activity modulates the shape of excitatory postsynaptic potentials (EPSPs) and increases the threshold for induction of LTP...
  10. Mechanisms of Fast Synaptic Facilitation in Colitis
    Eric Krauter; Fiscal Year: 2007
    ..It is the amplitude of individual fast excitatory postsynaptic potentials (fEPSPs) that determines if the postsynaptic cell reaches threshold and fires an action potential...
  11. PANCREATIC AND ENTERIC NEUROTRANSMISSION BY GLUTAMATE
    Annette Kirchgessner; Fiscal Year: 2001
    ..non-NMDA receptors, (3) that glutamate antagonists block some enteric and pancreatic fast and slow excitatory postsynaptic potentials (EPSPs), (4) that glutamate (and NMDA) raises [Ca2+]i in enteric neurons, (5) that pancreatic ..
  12. mGluR5 Regulation of METH Reward and Sensorimotor Gating
    AMY HERROLD; Fiscal Year: 2009
    ..will be normalized with mGluR5 NAM treatment via assessment of paired pulse facilitation of excitatory postsynaptic potentials recorded intracellularly in vivo...
  13. RETROHIPPOCAMPAL CIRCUITS MEDIATED EPILEPTIFORM ACTIVITY
    Mark Stewart; Fiscal Year: 2003
    ..The properties of unitary and compound excitatory postsynaptic potentials will be examined in identified cells...
  14. SYNAPTIC PLASTICITY IN HIPPOCAMPAL MOSSY CELLS
    BEN STROWBRIDGE; Fiscal Year: 1999
    ..depolarizing current pulses, there was a dramatic and prolonged enhancement of spontaneous excitatory postsynaptic potentials (EPSPs) recorded in that same cell...
  15. Synchronous Bursting among Juxtaglomerular Neurons
    Abdallah Hayar; Fiscal Year: 2006
    ..the functional significance of synchronous bursting by analyzing short-term facilitation of excitatory postsynaptic potentials that are evoked by ET cell bursts in periglomerular and short axon cells of the same glomerulus...
  16. Identification and characterization of two novel cannabinoid receptors
    Alex Straiker; Fiscal Year: 2008
    ..Marijuana is a major drug of abuse, acting via cannabinoid receptors. Knowing the identity and function of all cannabinoid receptors is key to understanding how marijuana affects the body. [unreadable] [unreadable] [unreadable]..
  17. PSYCHOTOGENIC DRUG ACTION ON CHEMICALLY DEFINED NEURONS
    George Aghajanian; Fiscal Year: 2008
    ..experiments focus upon how 5-HT2A receptor activation induces two distinct types glutamateric excitatory postsynaptic potentials/currents (EPSPs/EPSCs) at apical dendrites of layer V pyramidal cells of medial prefrontal cortex...
  18. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
  19. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2008
    ..These studies will help to elucidate general principles underlying the organization of polysensory neural systems generating behavior and their modification by learning. ..
  20. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  21. Cerebellar Afferent Integration Studied In Vitro
    Michael Ariel; Fiscal Year: 2007
    ..This in vitro preparation will thereby provide a unique model system for the study of learning and adaptation of motor behaviors. [unreadable] [unreadable]..
  22. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  23. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ....
  24. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  25. IONIC HOMEOSTASIS AND SEIZURE REGULATION
    John Swann; Fiscal Year: 2009
    ..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..
  26. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  27. BDNF AND HIPPOCAMPAL HYPEREXCITABILITY
    Helen Scharfman; Fiscal Year: 2008
    ..We will now address the hypothesis that BDNF induction by estrogen increases pyramidal cell activation, and the induction of VEGF by estrogen ensures that seizures are prevented. ..
  28. Dopamine Mechanisms and Receptors in Raphe 5-HT Neurons
    Samir Haj Dahmane; Fiscal Year: 2004
    ....
  29. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  30. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  31. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2004
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  32. HILAR NEURONS IN HIPPOCAMPAL NETWORK FUNCTION
    Helen Scharfman; Fiscal Year: 2002
    ..The results will provide insight into cognitive function that should ultimately help in the understanding and treatment of learning disorders and mental illness. ..
  33. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  34. BDNF AND HIPPOCAMPAL HYPEREXCITABILITY
    Helen E Scharfman; Fiscal Year: 2010
    ..Moreover, our data will provide support for new anticonvulsant strategies for women with epilepsy based on inhibiting BDNF or enhancing VEGF. ..
  35. INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURES
    Carl Faingold; Fiscal Year: 2002
    ..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..
  36. Cholinergic modulation of excitatory synapse formation
    Robert Levy; Fiscal Year: 2005
    ..These mechanisms are likely to underlie the influence of states of sleep, wakefulness, attention and arousal on the processes of learning and memory formation. ..
  37. PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS
    Michael Ariel; Fiscal Year: 2002
    ..This project analyzes these bilateral inputs to gain an understanding of their role in the natural processing that results in a normal sense of balance or produces the feeling of vertigo during a pathological condition. ..
  38. DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSY
    John Swann; Fiscal Year: 2007
    ..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
  39. Dynamics of a neural circuit that coordinates locomotion
    Brian Mulloney; Fiscal Year: 2009
    ..This research will be a model for study of limb coordination during locomotion in other animals, including the spinal circuits that are critical to locomotion in mammals, including man. ..
  40. KININS AS MEDIATORS OF HUMAN REACTIONS
    BRENDAN CANNING; Fiscal Year: 2003
    ..These rigorous studies will not only clarify the role of BK in airway diseases, but will also have broader relevance by providing new and important insights into how neural function is altered in asthma and rhinitis. ..
  41. AUTOMATED EXTRACTION OF METADATA FROM EXPERIMENT DESIGNS
    Yannick Pouliot; Fiscal Year: 2005
    ..The ultimate goal of the proposal is to facilitate the reuse of data from biomedical research's vast databases of experiment data by developing a tool for the automated capture of metadata. ..
  42. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..abstract_text> ..
  43. Mechanisms of synapse dysfunction in Alzheimer's disease
    Jane M Sullivan; Fiscal Year: 2011
    ..Understanding the cellular and molecular mechanisms underlying this synaptic dysfunction will provide new targets for therapeutic treatments to relieve symptoms, and slow or perhaps even stop disease progression. ..
  44. HTS Assay for Ca 3 T-type Channels Using FLIPR (RMI)
    Xinmin Xie; Fiscal Year: 2004
    ..The proposed fluorometric method will provide a high throughput and quantitative assay for the primary screening of compounds against three subtypes of Cav3 T-type channels. ..
  45. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  46. Development of HTS Platform for Human Fatty Acid Transport Protein 4 Using FLIPR
    Xinmin Xie; Fiscal Year: 2007
    ..Furthermore, they may form a basis for developing novel therapeutics for the treatment of metabolic disorders. ..
  47. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  48. Characterization of CA 1 hippocampal interneuron LTD
    Jeffrey Edwards; Fiscal Year: 2005
    ..Collectively, understanding the mechanisms mediating interneuron LTD will be important to correct for interneuron dysfunction in the hippocampus. ..
  49. Novel Neuropeptides as Targets for Psychiatric Disorders
    Xinmin Xie; Fiscal Year: 2005
    ..Our ultimate goal is to develop new therapeutics for indications in anxiety, depression, schizophrenia, or other pathological symptoms often modulated by the endogenous neuropeptide system. ..
  50. Transitions between synaptic states in the hippocampus
    JESSE HANSON; Fiscal Year: 2006
    ..We will also examine how different glutamate receptor components of the synaptic response are changed during potentiation of synapses that start in different states [unreadable] [unreadable]..
  51. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  52. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
    ....
  53. Dendritic Processing in the Olfactory Bulb
    Jason Christie; Fiscal Year: 2003
    ..The specific aims are: (1) to determine the function of autoexcitation in mitral cell processing and (2) to determine how dendritic compartmentalization effects mitral cell processing. ..
  54. Microneedle patches deliver a CGRP antagonist for neurogenic inflammatory pain
    Xinmin Xie; Fiscal Year: 2008
    ..We propose the development of an innovative anti-CGRP patch for the treatment of neurogenic inflammatory pain. [unreadable] [unreadable] [unreadable]..
  55. Integrins and LTP consolidation
    Gary Lynch; Fiscal Year: 2008
    ..The results of these experiments are expected to provide a strong test of a specific hypothesis regarding how LTP, and therefore possibly memory, becomes consolidated. ..
  56. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2008
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  57. Changes in cortical neurons and networks in mice overexpressing A beta
    Jack Waters; Fiscal Year: 2008
    ..These studies will provide critical insight into the cellular changes that occur in Alzheimer's disease and the resulting degeneration of neural networks. [unreadable] [unreadable] [unreadable]..
  58. CRCNS: Input/Output Relationship in CA3 Pyramidal Cells
    Giorgio Ascoli; Fiscal Year: 2008
    ..In addition to the dissemination of results in conferences and peer-reviewed publications, all models will be publicly distributed through internet archives. ..
  59. Acetylcholine and dopamine modulation in auditory cortex
    Marco Atzori; Fiscal Year: 2007
    ..Our specific aims are to determine how acetylcholine and dopamine modulate glutamatergic and GABAergic synaptic activity and how their interactions modulate or induce long-term plasticity in the auditory cortex. ..
  60. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..