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Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
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J Biol Chem 284:21696-706. 2009
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Cold Spring Harbor Laboratory, New York 11724
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Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
Nature 389:816-24. 1997
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Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
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Edward S Boyden
Department of Bioengineering, Stanford University, 318 Campus Drive West, Stanford, California 94305, USA
Nat Neurosci 8:1263-8. 2005
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Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Nat Rev Neurosci 5:793-807. 2004
..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
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Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt, Germany
Curr Biol 15:2279-84. 2005
..Thus, specific neurons or muscles expressing ChR2 can be quickly and reversibly activated by light in live and behaving, as well as dissected, animals...
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Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Neuron 37:311-22. 2003
..CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons...
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Jessica A Cardin
McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
Nature 459:663-7. 2009
..Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation...
- Molecular physiology of low-voltage-activated t-type calcium channels
Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
Physiol Rev 83:117-61. 2003
..The Cav3 subtypes can be differentiated by their kinetics and sensitivity to block by Ni2+. The goal of this review is to provide a comprehensive description of T-type currents, their distribution, regulation, pharmacology, and cloning...
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Elissa A Hallem
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Cell 117:965-79. 2004
..Receptors vary widely in their breadth of tuning, and odorants vary widely in the number of receptors they activate. Together, these properties provide a molecular basis for odor coding by the receptor repertoire of an olfactory organ...
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Benjamin R Arenkiel
Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Neuron 54:205-18. 2007
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R T Canolty
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Science 313:1626-8. 2006
..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
- Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
Neuron 49:107-17. 2006
..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
- Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli
Mark A Ungless
Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
Science 303:2040-2. 2004
..The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli...
- A cortical region consisting entirely of face-selective cells
Doris Y Tsao
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Science 311:670-4. 2006
..Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque...
- Diversity and dynamics of dendritic signaling
Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Science 290:739-44. 2000
..In this way, diversity in dendritic signaling allows individual neurons to carry out specialized functions within their respective networks...
- Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
Valerie B Caraiscos
Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 101:3662-7. 2004
- Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
J H Morais Cabral
Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York 10021, USA
Cell 95:649-55. 1998
..The presence of the domain attached to the channel slows the rate of deactivation. Given the roles of PAS domains in biology, we propose that the HERG N-terminal domain has a regulatory function...
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M E Larkum
Abt Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
Nature 398:338-41. 1999
- High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
Nat Rev Drug Discov 7:358-68. 2008
..target class, which is in large part due to the labour-intensive and low-throughput nature of patch-clamp electrophysiology. This Review provides an update on the current state-of-the-art for the various automated electrophysiology ..
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Dipartimento di Fisiologia e Biochimica Generali, Via Celoria 26, , Via Celoria 16, 20133 Milano, Italy
J Gen Physiol 117:519-32. 2001
..HCN voltage gating thus involves two processes: voltage sensor gating and allosteric opening/closing...
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Emery N Brown
Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Division of Health Sciences and Technology, Harvard Medical School, Boston, 02114, USA
Nat Neurosci 7:456-61. 2004
..Here we review statistical methods for the analysis of multiple neural spike-train data and discuss future challenges for methodology research...
- Interpreting the BOLD signal
Nikos K Logothetis
Max Planck Institut für biologische Kybernetik, Tubingen, Germany
Annu Rev Physiol 66:735-69. 2004
..We conclude with a discussion of how to use the BOLD signal to make inferences about the neural signal...
- Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 101:18206-11. 2004
..This approach is ideally suited for analysis of gene functions in individual neurons in the intact brain...
- The metabolic cost of neural information
S B Laughlin
Department of Zoology, University of Cambridge, UK
Nat Neurosci 1:36-41. 1998
..Therefore, in noise-limited signaling systems, a weak pathway of low capacity transmits information more economically, which promotes the distribution of information among multiple pathways...
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A L Harris
Department of Pharmacology and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Ave, University Heights, Newark, NJ 07103, USA
Q Rev Biophys 34:325-472. 2001
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- The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Department of Biosciences, University of Helsinki, Finland
Nature 397:251-5. 1999
..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
- Synaptic mechanisms of forward suppression in rat auditory cortex
Cold Spring Harbor Laboratory, New York 11724, USA
Neuron 47:437-45. 2005
- Practising orientation identification improves orientation coding in V1 neurons
Laboratorium voor Neuro en Psychofysiologie, K U Leuven Medical School, B 3000 Leuven, Belgium
Nature 412:549-53. 2001
..No modifications of the tuning curve were observed for orientations for which the monkey had not been trained. Thus training induces a specific and efficient increase in neuronal sensitivity in V1...
- Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
Christopher J Benson
Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 99:2338-43. 2002
..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
- Large-scale recording of neuronal ensembles
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
Nat Neurosci 7:446-51. 2004
- CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, New York 10021, USA
Nature 433:876-80. 2005
..This establishes a molecular mechanism, involving dynamic restructuring of the NBD dimer interface, that is probably common to all members of the ABC protein superfamily...
- Biological pattern generation: the cellular and computational logic of networks in motion
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
Neuron 52:751-66. 2006
..In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks...
- Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
H Christian Peters
Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Nat Neurosci 8:51-60. 2005
..M channels are thus critical determinants of cellular and neuronal network excitability, postnatal brain development and cognitive performance...
- The 5-HT3B subunit is a major determinant of serotonin-receptor function
P A Davies
Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
Nature 397:359-63. 1999
..In addition to providing a new target for therapeutic agents, the 5-HT3B subunit will be a valuable resource for defining the molecular mechanisms of ion-channel function...
- A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Shao Jun Tang
California Institute of Technology, Howard Hughes Medical Institute, Division of Biology 216 76, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 99:467-72. 2002
..The localization of this translational signaling pathway at postsynaptic sites may provide a mechanism that controls local protein synthesis at potentiated synapses...
- Fast and slow contrast adaptation in retinal circuitry
Stephen A Baccus
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Neuron 36:909-19. 2002
..Slow adaptation did not affect kinetics, but produced a gradual hyperpolarization. This hyperpolarization can account for slow adaptation in the spiking output of ganglion cells...
- Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
Nature 421:844-8. 2003
..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
- Functional conservation of an insect odorant receptor gene across 250 million years of evolution
Walton D Jones
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Curr Biol 15:R119-21. 2005
..The medical and economic impact of these animals can be ascribed in part to the sensitivity and selectivity of their olfactory systems, essential for location of their preferred plant and animal hosts...
- Internal dynamics determine the cortical response to thalamic stimulation
Jason N MacLean
Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Neuron 48:811-23. 2005
..Our data demonstrate that precise spatiotemporal activity patterns can be triggered by thalamic inputs and indicate that the thalamus serves to release intrinsic cortical dynamics...
- KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging
Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:3943-8. 2007
..That arrhythmias in both WT and KCNQ1 mutants become worse as flies age suggests that additional factors are also involved...
- Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance
Sean M Montgomery
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA
Proc Natl Acad Sci U S A 104:14495-500. 2007
..Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories...
- Insect odorant receptors are molecular targets of the insect repellent DEET
Laboratory of Neurogenetics and Behavior, Rockefeller University, 1230 York Avenue, Box 63, New York, NY 10065 USA
Science 319:1838-42. 2008
..The identification of candidate molecular targets for the action of DEET may aid in the design of safer and more effective insect repellents...
- The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?
Elyssa B Margolis
Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
J Physiol 577:907-24. 2006
..We conclude that reliable physiological criteria for VTA DA neuron identification have yet to be determined, and that the criteria currently being used are unreliable...
- Ephaptic coupling of cortical neurons
Costas A Anastassiou
Division of Biology, California Institute of Technology, Pasadena, California, USA
Nat Neurosci 14:217-23. 2011
..Our findings indicate that endogenous brain activity can causally affect neural function through field effects under physiological conditions...
- Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
K D Harris
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
Neuron 32:141-9. 2001
- Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
Neuron 34:437-46. 2002
..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
- Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 433:597-603. 2005
..These results indicate that cortical maps can be built with single-cell precision...
- Modulation of oscillatory neuronal synchronization by selective visual attention
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
Science 291:1560-3. 2001
..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
- Olfaction: mosquito receptor for human-sweat odorant
Elissa A Hallem
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
Nature 427:212-3. 2004
..Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests...
- Electrophysiology and brain imaging of biological motion
Centre for Advanced Imaging, Department of Radiology, West Virginia University, PO Box 9236, Morgantown 26506 9236, USA
Philos Trans R Soc Lond B Biol Sci 358:435-45. 2003
- Local origin of field potentials in visual cortex
Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
Neuron 61:35-41. 2009
..This quantitative estimate indicates that LFPs are more local than often recognized and provides a guide to the interpretation of the increasing number of studies that rest on LFP recordings...
- Excitatory actions of GABA in the cortex
Allan T Gulledge
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Mills Road, Canberra, ACT 0200, Australia
Neuron 37:299-309. 2003
..Our findings demonstrate that under certain circumstances GABA will have an excitatory role in synaptic integration in the cortex...
- The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
J Physiol 550:739-52. 2003
..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
- Pannexins, a family of gap junction proteins expressed in brain
Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 100:13644-9. 2003
- Allosteric control of an ionotropic glutamate receptor with an optical switch
Department of Chemistry, University of California, Berkeley, California 94720, USA
Nat Chem Biol 2:47-52. 2006
..Our device has potential uses not only in biology but also in bioelectronics and nanotechnology...
- Electrophysiology in the age of light
Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
Nature 461:930-9. 2009
b>Electrophysiology, the 'gold standard' for investigating neuronal signalling, is being challenged by a new generation of optical probes...
- Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels
K J Swartz
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
Neuron 18:675-82. 1997
..These results suggest that residues near the outer edges of S3 and S4 form the HaTx binding sites and are eccentrically located at least 15 A from the central pore axis on the surface of voltage-gated K+ channels...
- Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Cell 108:689-703. 2002
..Our analysis indicates that synaptic capture of CRE-driven gene products may be sufficient for consolidation of LTP and provides insight into the molecular mechanisms of synaptic tagging and synapse-specific potentiation...
- Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms
David J Pinto
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 25:8131-40. 2005
..These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages...
- The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel
Department of Pediatrics, University of Utah, Salt Lake City, Utah 94113, USA
J Biol Chem 281:12858-64. 2006
..Moreover, rather than functioning simply as a mechanical lever, these findings imply that specific interactions between the S4-S5 linker and the activation gate stabilize the closed channel conformation...
- The effect of correlated variability on the accuracy of a population code
L F Abbott
Volen Center, Brandeis University, Waltham MA 02254, USA
Neural Comput 11:91-101. 1999
..Furthermore, in some cases, but not all, correlations improve the accuracy of a population code...
- KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents
B C Schroeder
Zentrum fur Molekulare Neurobiologie Hamburg, Hamburg University, Martinistrasse 85, D 20246 Hamburg, Germany
J Biol Chem 275:24089-95. 2000
..A KCNQ5 splice variant found in skeletal muscle displays altered gating kinetics. This indicates a molecular diversity of channels yielding M-type currents and suggests a role for KCNQ5 in the regulation of neuronal excitability...
- Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
J Biol Chem 277:13569-77. 2002
..We concluded that the phorbol derivatives activate TRPV4 (VR-OAC, VRL-2, OTRPC4, TRP12) independently from protein kinase C, in a manner consistent with direct agonist gating of the channel...
- Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
Bryan C Hains
Department of Neurology and Paralyzed Veterans of America Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 23:8881-92. 2003
..3 expression and neuronal hyperexcitability associated with central neuropathic pain...
- Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels
Institut fur Biochemische Pharmakologie, Innsbruck, Austria
Cell 102:89-97. 2000
..We conclude that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity...
- Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin
Department of Physiology, University of Bern, Switzerland
Circ Res 93:421-8. 2003
..This synchronization is accompanied by extremely large local conduction delays, which might contribute to the generation of arrhythmias in fibrotic hearts...
- Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons
Candice C Askwith
Department of Internal Medicine, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 279:18296-305. 2004
..These findings indicate that the absolute and relative amounts of ASIC subunits determine the amplitude and properties of hippocampal H(+)-gated currents and therefore may contribute to normal physiology and pathophysiology...
- Applications of random field theory to electrophysiology
James M Kilner
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Neurosci Lett 374:174-8. 2005
..Here, by analysing the time-frequency decompositions of single channel EEG data we show that RFT adjustments can be used in the analysis of electrophysiological data and illustrate the advantages of this method over existing approaches...
- Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues
Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
Neuron 65:461-71. 2010
..This result suggests that the beta amplitude and delta phase in MI reflect the subject's engagement with the rhythmically presented cues and work together to enhance sensitivity to predictable and task-relevant visual cues...
- A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX
Department of Biochemistry, University of Geneva, Switzerland
Neuron 5:847-56. 1990
..A bacterial fusion protein encompassing residues 124-239 of alpha 7 binds labeled alpha-bungarotoxin. We conclude that alpha-bungarotoxin binding proteins in the vertebrate nervous system can function as nAChRs...
- In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex
T H Schwartz
Max Planck Institut fur Neurobiologie, München Martinsried, Germany
Nat Med 7:1063-7. 2001
..Optical mapping of epilepsy might be a useful adjunct in the surgical treatment of neocortical epilepsy, which critically depends on the precise localization of intrinsically epileptogenic neurons...
- Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine
Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Proc Natl Acad Sci U S A 100:15194-9. 2003
..By providing extracellular D-serine that facilitates activation of NMDA receptors, astrocytes thus play a key role in long-term synaptic plasticity...
- Target cell-specific modulation of transmitter release at terminals from a single axon
Laboratoire de Physiologie, Ecole Superieure de Physique et Chimie Industrielles, F 75231 Paris, France
Proc Natl Acad Sci U S A 95:12004-9. 1998
..On the basis of these results, we conclude that the pharmacological and physiological properties of presynaptic terminals are determined, at least in part, by the target cells...
- An ultra-sparse code underlies the generation of neural sequences in a songbird
Richard H R Hahnloser
Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
Nature 419:65-70. 2002
- Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurophysiol 89:1588-602. 2003
- The spine neck filters membrane potentials
Howard Hughes Medical Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Proc Natl Acad Sci U S A 103:17961-6. 2006
..We conclude that the spine neck plays an electrical role in the transmission of membrane potentials, isolating synapses electrically...
- Integrating electrophysiology and neuroimaging of spatial selective attention to simple isolated visual stimuli
G R Mangun
Center for Cognitive Neuroscience, Duke University, Box 90999, Durham, NC 27708, USA
Vision Res 41:1423-35. 2001
- Attention-like processes in Drosophila require short-term memory genes
Bruno van Swinderen
Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
Science 315:1590-3. 2007
..These processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga. Attention defects in these mutants were associated with distinct optomotor effects in behavioral assays...
- Structure and regulation of voltage-gated Ca2+ channels
W A Catterall
Department of Pharmacology, Box 357280, University of Washington, Seattle, Washington 98195 7280, USA
Annu Rev Cell Dev Biol 16:521-55. 2000
- Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach
Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, University of Firenze, Firenze, Italy
Stem Cells 25:1136-44. 2007
..In summary, human embryonic stem cell-derived cardiomyocytes mature over time during in vitro differentiation, approaching an adult phenotype. Disclosure of potential conflicts of interest is found at the end of this article...
- General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel
L J Brunet
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Neuron 17:681-93. 1996
..Our results provide direct evidence that the CNG channel subserves excitatory olfactory signal transduction, and further suggest that cAMP is the sole second messenger mediating this process...
- Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
M C Sanguinetti
Eccles Program in Human Molecular Biology and Genetics, Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, UT 84112
J Physiol 514:667-75. 1999
..5. The results indicate that the S4-S5 linker is a crucial component of the activation gate of HERG channels...
- The dynamic clamp comes of age
Astrid A Prinz
Volen Center and Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
Trends Neurosci 27:218-24. 2004
- Novelty acquisition is associated with induction of hippocampal long-term depression
Leibniz Institute for Neurobiology, Departments of Neurophysiology, Magdeburg, Germany
Proc Natl Acad Sci U S A 96:8739-44. 1999
..Behavioral comparison between the first and second environmental exposure confirmed that the animals had habituated to the novel environment. These observations strongly implicate an association between novelty acquisition and LTD...
- Spatio-temporal dynamics of odor representations in the mammalian olfactory bulb
The Department of Neurobiology, Weizmann Institute of Science, 76100, Rehovot, Israel
Neuron 34:301-15. 2002
..Our data show that in the mammalian olfactory bulb, odor identity and concentration are represented by spatio-temporal patterns, rather than spatial patterns alone...
- Ion channel properties underlying axonal action potential initiation in pyramidal neurons
Costa M Colbert
Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5513, USA
Nat Neurosci 5:533-8. 2002
- Patches with links: a unified system for processing faces in the macaque temporal lobe
Institute for Brain Research and Center for Advanced Imaging, University of Bremen, Post Office Box 330440, D 28334 Bremen, Germany
Science 320:1355-9. 2008
..Stimulation outside the face patches produced an activation pattern that spared the face patches. These results suggest that the face patches form a strongly and specifically interconnected hierarchical network...
- Store-operated calcium channels
Anant B Parekh
Department of Physiology, University of Oxford, United Kingdom
Physiol Rev 85:757-810. 2005
- Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
Nathaniel T Blair
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 20114, USA
J Neurosci 22:10277-90. 2002
- Information processing in the axon
Equipe INSERM AVENIR, Plasticité de l excitabilité neuronale, Neurobiologie des Canaux Ioniques INSERM U641, Institut Federatif de Recherche Jean Roche, Universite de la Mediterranee, Marseille, France
Nat Rev Neurosci 5:304-16. 2004
- Functional organization of ferret auditory cortex
Jennifer K Bizley
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
Cereb Cortex 15:1637-53. 2005
..The presence of both tonotopic and non-tonotopic auditory cortical fields indicates that the organization of ferret auditory cortex is comparable to that seen in other mammals...
- Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin
Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 102:17816-21. 2005
..Thus light-activated vertebrate RO4 and green algae ChR2 allow the antagonistic control of neuronal function within ms to s in a precise, reversible, and noninvasive manner in cultured neurons and intact vertebrate spinal cords...
- Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation
Division of Cardiology, Goethe University, Frankfurt, Germany
Heart Rhythm 6:1802-9. 2009
..MicroRNA-1 (miR-1) reciprocally regulates inwardly rectifying potassium channel (Kir)2.1 expression in coronary disease, contributing to arrhythmogenesis...
- Identified GnRH neuron electrophysiology: a decade of study
Suzanne M Moenter
Department of Molecular and Integrative Physiology, 7725 Med Sci II, 1301 E Catherine St, Ann Arbor, MI 48109 5622, USA
Brain Res 1364:10-24. 2010
..Advances in our understanding of neuromodulation of GnRH neurons and synchronization of this network are also discussed...
- Electromagnetic field effect or simply stress? Effects of UMTS exposure on hippocampal longterm plasticity in the context of procedure related hormone release
Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany
PLoS ONE 6:e19437. 2011
- Learning to see: experience and attention in primary visual cortex
R E Crist
The Rockefeller University, New York, New York 10021, USA
Nat Neurosci 4:519-25. 2001
..Furthermore, this property showed task dependence, only being manifest when the animal was performing the trained discrimination...
- Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers
Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Circulation 111:11-20. 2005
..Although CMs can be derived from hESCs ex vivo, it remains uncertain whether a functional syncytium can be formed between donor and recipient cells after engraftment...