biology

Summary

Summary: One of the biological sciences concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.

Top Publications

  1. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
  2. pmc ZINC: a free tool to discover chemistry for biology
    John J Irwin
    Department of Pharmaceutical Chemistry, Byers Hall, University of California San Francisco, 1700 fourth St, Box 2550, San Francisco, California 94158 2330, United States
    J Chem Inf Model 52:1757-68. 2012
  3. ncbi Next-generation sequencing transforms today's biology
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
    Nat Methods 5:16-8. 2008
  4. pmc Differential network biology
    Trey Ideker
    Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA, USA
    Mol Syst Biol 8:565. 2012
  5. pmc OMERO: flexible, model-driven data management for experimental biology
    Chris Allan
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Nat Methods 9:245-53. 2012
  6. ncbi Timing to perfection: the biology of central and peripheral circadian clocks
    Urs Albrecht
    Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Neuron 74:246-60. 2012
  7. ncbi Systems biology: a brief overview
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
    Science 295:1662-4. 2002
  8. ncbi The second wave of synthetic biology: from modules to systems
    Priscilla E M Purnick
    Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Mol Cell Biol 10:410-22. 2009
  9. ncbi Feature point tracking and trajectory analysis for video imaging in cell biology
    I F Sbalzarini
    Institute of Computational Science, ETH Zurich, 8092 Zurich, Switzerland
    J Struct Biol 151:182-95. 2005
  10. pmc Increased course structure improves performance in introductory biology
    Scott Freeman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    CBE Life Sci Educ 10:175-86. 2011

Research Grants

  1. Scientific Meeting: Mechanisms of Cell Death
    Zahra Zakeri; Fiscal Year: 2006
  2. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
  3. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
  4. SIGNALING PATHWAYS INTERACTIONS AND MAMMARY TUMOR
    SRINIVAS RAVI IYENGAR; Fiscal Year: 2004
  5. STRUCTURE AND FUNCTION OF SIGNAL TRANSDUCING COMPONENTS
    SRINIVAS RAVI IYENGAR; Fiscal Year: 2008
  6. Perinatal Determinants of Intersensory Perception
    Robert Lickliter; Fiscal Year: 2009
  7. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
  8. CATENINS, EPITHELIAL BEHAVIOR AND GENE EXPRESSION
    Michael Klymkowsky; Fiscal Year: 2004
  9. PEPTIDE SYNTHESIZER
    Sherwin Wilk; Fiscal Year: 2001
  10. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010

Detail Information

Publications262 found, 100 shown here

  1. ncbi Rho GTPases: biochemistry and biology
    Aron B Jaffe
    MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
    Annu Rev Cell Dev Biol 21:247-69. 2005
    ..networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division...
  2. pmc ZINC: a free tool to discover chemistry for biology
    John J Irwin
    Department of Pharmaceutical Chemistry, Byers Hall, University of California San Francisco, 1700 fourth St, Box 2550, San Francisco, California 94158 2330, United States
    J Chem Inf Model 52:1757-68. 2012
    ..Small custom subsets may be created, edited, shared, docked, downloaded, and conveyed to a vendor for purchase. The database is maintained and curated for a high purchasing success rate and is freely available at zinc.docking.org...
  3. ncbi Next-generation sequencing transforms today's biology
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
    Nat Methods 5:16-8. 2008
    ..However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years...
  4. pmc Differential network biology
    Trey Ideker
    Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA, USA
    Mol Syst Biol 8:565. 2012
    ....
  5. pmc OMERO: flexible, model-driven data management for experimental biology
    Chris Allan
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Nat Methods 9:245-53. 2012
    ..OMERO's design and flexibility have enabled its use for light-microscopy, high-content-screening, electron-microscopy and even non-image-genotype data. OMERO is open-source software, available at http://openmicroscopy.org/...
  6. ncbi Timing to perfection: the biology of central and peripheral circadian clocks
    Urs Albrecht
    Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Neuron 74:246-60. 2012
    ..This review will highlight the relationship between clocks and metabolism, and describe how cues such as light, food, and reward mediate entrainment of the circadian system...
  7. ncbi Systems biology: a brief overview
    Hiroaki Kitano
    Sony Computer Science Laboratories, Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
    Science 295:1662-4. 2002
    To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism...
  8. ncbi The second wave of synthetic biology: from modules to systems
    Priscilla E M Purnick
    Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Mol Cell Biol 10:410-22. 2009
    Synthetic biology is a research field that combines the investigative nature of biology with the constructive nature of engineering...
  9. ncbi Feature point tracking and trajectory analysis for video imaging in cell biology
    I F Sbalzarini
    Institute of Computational Science, ETH Zurich, 8092 Zurich, Switzerland
    J Struct Biol 151:182-95. 2005
    ..the automated detection and quantitative analysis of particle trajectories as recorded by video imaging in cell biology. The tracking process requires no a priori mathematical modeling of the motion, it is self-initializing, it ..
  10. pmc Increased course structure improves performance in introductory biology
    Scott Freeman
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    CBE Life Sci Educ 10:175-86. 2011
    ..in-class active-learning activities and weekly practice exams, can lower failure rates in an introductory biology course for majors, compared with low-structure course designs that are based on lecturing and a few high-risk ..
  11. pmc Active learning not associated with student learning in a random sample of college biology courses
    T M Andrews
    Department of Ecology, Montana State University, Bozeman, USA
    CBE Life Sci Educ 10:394-405. 2011
    ..The present study investigated introductory biology courses randomly selected from a list of prominent colleges and universities to include instructors representing ..
  12. pmc The biology of infertility: research advances and clinical challenges
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Med 14:1197-213. 2008
    ..Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care...
  13. ncbi Increased structure and active learning reduce the achievement gap in introductory biology
    David C Haak
    Department of Biology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Science 332:1213-6. 2011
    ..and other higher-order cognitive skills, improved the performance of all students in a college-level introductory biology class and reduced the achievement gap between disadvantaged and nondisadvantaged students--without increased ..
  14. pmc The Colorado Learning Attitudes about Science Survey (CLASS) for use in Biology
    Katharine Semsar
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    CBE Life Sci Educ 10:268-78. 2011
    This paper describes a newly adapted instrument for measuring novice-to-expert-like perceptions about biology: the Colorado Learning Attitudes about Science Survey for Biology (CLASS-Bio)...
  15. ncbi The concept of allostasis in biology and biomedicine
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Horm Behav 43:2-15. 2003
    ..If allostatic load is chronically high, then pathologies develop. Type 2 allostatic overload does not trigger an escape response, and can only be counteracted through learning and changes in the social structure...
  16. pmc Machine learning and its applications to biology
    Adi L Tarca
    PLoS Comput Biol 3:e116. 2007
  17. pmc Biology undergraduates' misconceptions about genetic drift
    T M Andrews
    Department of Ecology, Montana State University, Bozeman, MT 59717, USA
    CBE Life Sci Educ 11:248-59. 2012
    This study explores biology undergraduates' misconceptions about genetic drift...
  18. pmc Biology in bloom: implementing Bloom's Taxonomy to enhance student learning in biology
    Alison Crowe
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    CBE Life Sci Educ 7:368-81. 2008
    We developed the Blooming Biology Tool (BBT), an assessment tool based on Bloom's Taxonomy, to assist science faculty in better aligning their assessments with their teaching activities and to help students enhance their study skills and ..
  19. pmc Modular cell biology: retroactivity and insulation
    Domitilla Del Vecchio
    Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Syst Biol 4:161. 2008
    ..We introduce, in particular, a mechanism based on a phosphorylation-dephosphorylation cycle. This mechanism enjoys a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation reactions...
  20. pmc Microscale technologies for tissue engineering and biology
    Ali Khademhosseini
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:2480-7. 2006
    ..discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology. Throughout this review, we will use specific examples where available and will provide trends and future ..
  21. ncbi Perspective of cytokine regulation for periodontal treatment: fibroblast biology
    Shogo Takashiba
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Periodontol 74:103-10. 2003
    ..This paper will review the utilization of soluble receptors specific to inflammatory cytokines which potentially stimulate fibroblasts to regulate biological events involved in the pathogenesis of periodontal diseases...
  22. pmc Bright ideas for chemical biology
    Luke D Lavis
    Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    ACS Chem Biol 3:142-55. 2008
    Small-molecule fluorescent probes embody an essential facet of chemical biology. Although numerous compounds are known, the ensemble of fluorescent probes is based on a modest collection of modular "core" dyes...
  23. pmc Understanding randomness and its impact on student learning: lessons learned from building the Biology Concept Inventory (BCI)
    Kathy Garvin-Doxas
    Center for Integrated Plasma Studies, and Developmental Biology Department, University of Colorado, Boulder, CO 80309, USA
    CBE Life Sci Educ 7:227-33. 2008
    While researching student assumptions for the development of the Biology Concept Inventory (BCI; http://bioliteracy...
  24. pmc Error bars in experimental biology
    Geoff Cumming
    School of Psychological Science and 2Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia 3086
    J Cell Biol 177:7-11. 2007
    ..Different types of error bars give quite different information, and so figure legends must make clear what error bars represent. We suggest eight simple rules to assist with effective use and interpretation of error bars...
  25. ncbi Important role of integrins in the cancer biology
    R Rathinam
    Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center, LSU School of Medicine, 1901 Perdido Street, New Orleans, LA, 70112, USA
    Cancer Metastasis Rev 29:223-37. 2010
    ..Also, we highlight the importance of integrin-binding proteins in cell migration and mechanisms that operate in invasive cells, during breast cancer progression...
  26. ncbi Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    Brian I Rini
    University of California San Francisco Comprehensive Cancer Center, CA, USA
    J Clin Oncol 23:1028-43. 2005
    To review the biology of renal cell carcinoma (RCC) leading to vascular endothelial growth factor (VEGF) overexpression and the clinical results of VEGF blockade in metastatic RCC.
  27. pmc Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems
    Caleb J Bashor
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 2517, USA
    Annu Rev Biophys 39:515-37. 2010
    ..and the goal of predictively and quantitatively understanding its function is one of the next great challenges in biology. Much of what we know about the cell concerns its constituent parts, but to a great extent we have yet to decode ..
  28. ncbi Structural biology and chemistry of the terpenoid cyclases
    David W Christianson
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
    Chem Rev 106:3412-42. 2006
  29. ncbi X-ray lasers for structural and dynamic biology
    J C H Spence
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Rep Prog Phys 75:102601. 2012
    ..and techniques are reviewed for the application of hard x-ray pulsed free-electron lasers (XFEL) to structural biology. These include the imaging of protein nanocrystals, single particles such as viruses, pump--probe experiments for ..
  30. pmc Using the principles of BIO2010 to develop an introductory, interdisciplinary course for biology students
    Kelly E Matthews
    Teaching and Educational Development Institute and Faculty of Science, University of Queensland, Brisbane, QLD, Australia
    CBE Life Sci Educ 9:290-7. 2010
    ..The results support the recommendation from BIO2010 that mathematics should be introduced to biology students in first-year courses using real-world examples, while challenging the benefits of introducing ..
  31. pmc Learner-centered inquiry in undergraduate biology: positive relationships with long-term student achievement
    Terry L Derting
    Department of Biological Sciences, Murray State University, KY 42071, USA
    CBE Life Sci Educ 9:462-72. 2010
    We determined short- and long-term correlates of a revised introductory biology curriculum on understanding of biology as a process of inquiry and learning of content...
  32. ncbi Cause and effect in biology revisited: is Mayr's proximate-ultimate dichotomy still useful?
    Kevin N Laland
    School of Biology, University of St Andrews, St Andrews KY16 9TS, UK
    Science 334:1512-6. 2011
    Fifty years ago, Ernst Mayr published a hugely influential paper on the nature of causation in biology, in which he distinguished between proximate and ultimate causes...
  33. pmc Osmosis and diffusion conceptual assessment
    Kathleen M Fisher
    Department of Biology, San Diego State University, CA 92182 4614, USA
    CBE Life Sci Educ 10:418-29. 2011
    b>Biology student mastery regarding the mechanisms of diffusion and osmosis is difficult to achieve...
  34. pmc Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish
    Brian S Clark
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 240:2452-65. 2011
    ..To facilitate in vivo investigation of specific Rab proteins, and endosome biology in general, we have generated transgenic zebrafish lines to mark and manipulate Rab proteins...
  35. pmc Ceramide synthases at the centre of sphingolipid metabolism and biology
    Thomas D Mullen
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochem J 441:789-802. 2012
    ..manner, CerSs appear to regulate multiple aspects of sphingolipid-mediated cell and organismal biology. In the present review, we discuss the function of CerSs as critical regulators of sphingolipid metabolism, ..
  36. pmc Directing experimental biology: a case study in mitochondrial biogenesis
    Matthew A Hibbs
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Princeton, New Jersey, United States of America
    PLoS Comput Biol 5:e1000322. 2009
    ..experimentally validated on a large scale, leaving many bioinformatic methods unproven and underutilized in the biology community...
  37. ncbi The virtual cell: an integrated modeling environment for experimental and computational cell biology
    Ion I Moraru
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 3505, USA
    Ann N Y Acad Sci 971:595-6. 2002
  38. pmc Web API for biology with a workflow navigation system
    Yeondae Kwon
    Laboratory for Research and Development of Biological Databases, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Nucleic Acids Res 37:W11-6. 2009
    DNA Data Bank of Japan (DDBJ) provides Web-based systems for biological analysis, called Web APIs for biology (WABI). So far, we have developed over 20 SOAP services and several workflows that consist of a series of method invocations...
  39. ncbi Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health
    Filippos Ververidis
    Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational Institute of Crete, Heraklion, Crete, Greece
    Biotechnol J 2:1214-34. 2007
    ....
  40. ncbi Network structure and the biology of populations
    Robert M May
    Zoology Department, South Parks Road, Oxford University, Oxford, UK, OX1 3PS
    Trends Ecol Evol 21:394-9. 2006
    ..I offer caveats and opinionated comment about some excesses of enthusiasm and suggest some areas where these network ideas might find further application...
  41. ncbi Evolution. The tree-thinking challenge
    David A Baum
    Department of Botany, University of Wisconsin, 430 Lincoln Drive, Madison, WI 53706, USA
    Science 310:979-80. 2005
  42. pmc Biology of Pseudomonas stutzeri
    Jorge Lalucat
    Department de Biologia, Microbiologia, Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain
    Microbiol Mol Biol Rev 70:510-47. 2006
    ..This review considers the history of the discovery, nomenclatural changes, and early studies, together with the relevant biological and ecological properties, of P. stutzeri...
  43. pmc Active learning and student-centered pedagogy improve student attitudes and performance in introductory biology
    Peter Armbruster
    Department of Biology, Georgetown University, Washington, DC 20057, USA
    CBE Life Sci Educ 8:203-13. 2009
    ..multiple forms of active learning and student-centered pedagogies to a one-semester, undergraduate introductory biology course for both majors and nonmajors...
  44. pmc Molecular simulations of protein dynamics: new windows on mechanisms in biology
    Guy G Dodson
    University of York, York YO10 5YW, UK
    EMBO Rep 9:144-50. 2008
    ..Here, we highlight some examples of such approaches that illustrate the current state and potential of the field of molecular simulation...
  45. ncbi Platelet rich plasma: biology and new technology
    William S Pietrzak
    Biomet, Inc, Warsaw, IN 46580 0587, USA
    J Craniofac Surg 16:1043-54. 2005
    ..This article presents fundamental background on platelet biology and the role of platelets in both hemostasis and wound healing, as well as methods of preparing, characterizing, ..
  46. ncbi State of the nation in data integration for bioinformatics
    Carole Goble
    School of Computer Science, University of Manchester, Oxford Road, Manchester M139PL, UK
    J Biomed Inform 41:687-93. 2008
    ..The paper expands on that talk. We attempt to place some perspective on past efforts, highlight the reasons for success and failure, and indicate some pointers to the future...
  47. ncbi Graph theory and networks in Biology
    O Mason
    Hamilton Institute, National University of Ireland, Maynooth, Co Kildare, Ireland
    IET Syst Biol 1:89-119. 2007
    A survey of the use of graph theoretical techniques in Biology is presented...
  48. ncbi Electromagnetic effects - From cell biology to medicine
    Richard H W Funk
    Technische Universitat Dresden, Medizinische Fakultät Carl Gustav Carus, Institut fur Anatomie, Germany
    Prog Histochem Cytochem 43:177-264. 2009
    ..Here, modern molecular biology could link the action of ion transporters and ion channels to the "electric" action of cells and tissues...
  49. ncbi Effects of static magnetic fields in biology: role of free radicals
    Hideyuki Okano
    International Innovation Center, Kyoto University, Kyoto, Japan
    Front Biosci 13:6106-25. 2008
    ..However, health and environmental concerns have been raised because the SMF effects on oxidative stress leading to genetic mutation and apoptosis/necrosis have been found. It seems to take place from free radical generation...
  50. ncbi Fundamental plant biology enabled by the space shuttle
    Anna Lisa Paul
    Horticultural Science Department, University of Florida, Gainesville, Florida 32610, USA
    Am J Bot 100:226-34. 2013
    The relationship between fundamental plant biology and space biology was especially synergistic in the era of the Space Shuttle...
  51. pmc Short lesson plan associated with increased acceptance of evolutionary theory and potential change in three alternate conceptions of macroevolution in undergraduate students
    Joel K Abraham
    California State University, Fullerton, Fullerton, CA 92834, USA
    CBE Life Sci Educ 11:152-64. 2012
    Undergraduates commonly harbor alternate conceptions about evolutionary biology; these alternate conceptions often persist, even after intensive instruction, and may influence acceptance of evolution...
  52. ncbi Seeing the forest for the trees: the limitations of phylogenies in comparative biology. (American Society of Naturalists Address)
    Jonathan B Losos
    Museum of Comparative Zoology and Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am Nat 177:709-27. 2011
    The past 30 years have seen a revolution in comparative biology. Before that time, systematics was not at the forefront of the biological sciences, and few scientists considered phylogenetic relationships when investigating evolutionary ..
  53. ncbi Measurement and meaning in biology
    David Houle
    Centre for Ecological and Evolutionary Synthesis, University of Oslo, 0316 Oslo, Norway
    Q Rev Biol 86:3-34. 2011
    ..Despite this central role, measurement theory is almost unknown in biology, and its principles are frequently violated...
  54. pmc Nanoscale interfaces to biology
    Sunho Park
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 14:616-22. 2010
    Nanotechnology has held great promise for revolutionizing biology. The biological behavior of nanomaterials depends primarily on how they interface to biomolecules and their surroundings...
  55. ncbi From physics to biology by extending criticality and symmetry breakings
    G Longo
    Informatique, CNRS et École Normale Supérieure, Paris et CREA, Polytechnique, France
    Prog Biophys Mol Biol 106:340-7. 2011
    ..We then introduce our ongoing theoretical analysis in biology and show that symmetries play a radically different role in this discipline, when compared to those in current ..
  56. pmc Just the facts? Introductory undergraduate biology courses focus on low-level cognitive skills
    Jennifer L Momsen
    Department of Plant Biology, Michigan State University, East Lansing, 48824, USA
    CBE Life Sci Educ 9:435-40. 2010
    Introductory biology courses are widely criticized for overemphasizing details and rote memorization of facts. Data to support such claims, however, are surprisingly scarce. We sought to determine whether this claim was evidence-based...
  57. ncbi Emergence of the chicken as a model organism: implications for agriculture and biology
    D W Burt
    Roslin Institute, Edinburgh, Midlothian EH25 9PS, United Kingdom
    Poult Sci 86:1460-71. 2007
    ..These advances are reviewed and their implications are discussed...
  58. ncbi Structural biology in fragment-based drug design
    Christopher W Murray
    Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom
    Curr Opin Struct Biol 20:497-507. 2010
    ..Here we examine the recent literature looking at how structural biology has been used in a variety of successful fragment-screening applications...
  59. pmc Vision and change in biology undergraduate education, a call for action--initial responses
    TERRY WOODIN
    National Science Foundation, Arlington, VA 22230, USA
    CBE Life Sci Educ 9:71-3. 2010
    ..provides an overview of some of V&C's key recommendations regarding next steps in the effort to mobilize the biology community. It is, in essence, a call for national service...
  60. pmc The evolving biology and treatment of prostate cancer
    Russel S Taichman
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
    J Clin Invest 117:2351-61. 2007
    ..As the population ages and prostate cancer prevalence increases, challenges remain in the diagnosis of clinically relevant prostate cancer as well as the management of the metastatic and androgen-independent metastatic disease states...
  61. ncbi The biology of epilepsy genes
    Jeffrey L Noebels
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Annu Rev Neurosci 26:599-625. 2003
    ..This review selects exemplary members of several gene families to illustrate principal categories of the disease and trace the biological pathways to epileptogenesis in the developing brain...
  62. ncbi Transforming growth factor-beta : biology and clinical relevance
    Isaac Yi Kim
    Department of Urology, University of California at Irvine, Orange, CA 92868, USA
    J Biochem Mol Biol 38:1-8. 2005
    ..In this report, we will review these clinical implications of transforming growth factor-beta ...
  63. ncbi Self-organization in cell biology: a brief history
    Eric Karsenti
    Eric Karsenti is at the Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Rev Mol Cell Biol 9:255-62. 2008
    ..Self-organization concepts that were first developed in chemistry and physics and then applied to various morphogenetic problems in biology over the past century are now beginning to be applied to the organization of the living cell.
  64. pmc Recent insights into the biology and biomedical applications of Flock House virus
    P A Venter
    Department of Molecular Biology, CB262, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Mol Life Sci 65:2675-87. 2008
    ..Finally, applications for FHV as an epitopepresenting system are described with particular reference to its recent use for the development of a novel anthrax antitoxin and vaccine...
  65. ncbi The Virtual Cell: a software environment for computational cell biology
    L M Loew
    Center for Biomedical Imaging Technology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Trends Biotechnol 19:401-6. 2001
    The newly emerging field of computational cell biology requires software tools that address the needs of a broad community of scientists...
  66. ncbi Infusion of collaborative inquiry throughout a biology curriculum increases student learning: a four-year study of "Teams and Streams"
    Douglas B Luckie
    Lyman Briggs School of Science, Michigan State University, East Lansing, MI 48825, USA
    Adv Physiol Educ 28:199-209. 2004
    Are traditional laboratories in the core introductory biology courses teaching physiology majors the art and trade of science, or simply leaving them with a memory of trivial experiments done for unknown reasons? Our students, a ..
  67. pmc Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory
    Fulvio Mazzocchi
    Institute for Atmospheric Pollution, Consiglio Nazionale delle Ricerche, Monterotondo, Rome, Italy
    EMBO Rep 9:10-4. 2008
  68. ncbi Clinical and therapeutical implications of EPC biology in atherosclerosis
    N Werner
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
    J Cell Mol Med 10:318-32. 2006
    ..In this review we focus on the role of circulating endothelial progenitor cells in endothelial cell repair mechanisms at the vascular wall and their potentially protective and therapeutic role in atherosclerotic disease...
  69. ncbi Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
    Kumar Sambamurti
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neuromolecular Med 1:1-31. 2002
    ..The present review summarizes our current understanding of APP metabolism and function and their relationship to other proteins involved in AD...
  70. pmc Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology
    David P Hill
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME 04609, USA
    BMC Genomics 14:513. 2013
    ....
  71. pmc Multi-scale modeling in biology: how to bridge the gaps between scales?
    Zhilin Qu
    Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Prog Biophys Mol Biol 107:21-31. 2011
    ..modeling, as a computational approach, has been widely adopted by researchers in computational and systems biology. A key unsolved issue is how to represent appropriately the dynamical behaviors of a high-dimensional model of a ..
  72. pmc 1, 2, 3, 4: infusing quantitative literacy into introductory biology
    Elena Bray Speth
    Department of Biology, Saint Louis University, St Louis, MO 63103, USA
    CBE Life Sci Educ 9:323-32. 2010
    b>Biology of the twenty-first century is an increasingly quantitative science. Undergraduate biology education therefore needs to provide opportunities for students to develop fluency in the tools and language of quantitative disciplines...
  73. pmc Meeting report: the 2004 National Academies Summer Institute on Undergraduate Education in Biology
    William B Wood
    Department of MCD Biology, University of Colorado, Boulder, USA
    Cell Biol Educ 3:215-7. 2004
  74. pmc Common origins of diverse misconceptions: cognitive principles and the development of biology thinking
    John D Coley
    Department of Psychology, Northeastern University, Boston, MA 02115 5000, USA
    CBE Life Sci Educ 11:209-15. 2012
    ..conversation, and we think that expanding this conversation to include other biological scientists and educators, as well as other cognitive scientists, could have significant utility in improving biology teaching and learning.
  75. pmc Bioimage informatics for experimental biology
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Annu Rev Biophys 38:327-46. 2009
    ..advances in light microscopy with the result that multidimensional imaging has driven a revolution in modern biology. The development of new approaches of data acquisition is reported frequently, and yet the significant data ..
  76. ncbi Predictive accuracy of population viability analysis in conservation biology
    B W Brook
    Key Centre for Biodiversity and Bioresources, Department of Biological Sciences, Macquarie University, New South Wales, Australia
    Nature 404:385-7. 2000
    Population viability analysis (PVA) is widely applied in conservation biology to predict extinction risks for threatened species and to compare alternative options for their management...
  77. pmc We know too little about parasitoid wasp distributions to draw any conclusions about latitudinal trends in species richness, body size and biology
    Donald L J Quicke
    Department of Life Science, Imperial College London, Ascot, Berkshire, United Kingdom
    PLoS ONE 7:e32101. 2012
    Much has been written about latitudinal trends in parasitoid diversity and biology, though it is widely recognised that they are a comparatively poorly known group...
  78. ncbi Research on small genomes: implications for synthetic biology
    Lisa Klasson
    Department of Molecular Evolution, Uppsala University, Uppsala, Sweden
    Bioessays 32:288-95. 2010
    ..Synthetic biology may ultimately enable researchers to make customized cell-specific organelles for the production and delivery of ..
  79. ncbi An extended synthesis for evolutionary biology
    Massimo Pigliucci
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Ann N Y Acad Sci 1168:218-28. 2009
    ..I argue that evolutionary biology has never seen a paradigm shift, in the philosophical sense of the term, except when it moved from natural ..
  80. ncbi Mammalian synthetic biology--from tools to therapies
    Dominique Aubel
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
    Bioessays 32:332-45. 2010
    Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported...
  81. pmc Biology using engineering tools: the negative feedback amplifier
    Marc R Birtwistle
    Systems Biology Ireland, University College Dublin, Belfield, Dublin, Republic of Ireland
    Cell Cycle 10:2069-76. 2011
    ..Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer...
  82. pmc Physical properties of biological entities: an introduction to the ontology of physics for biology
    Daniel L Cook
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, USA
    PLoS ONE 6:e28708. 2011
    ..In this paper, we introduce the Ontology of Physics for Biology (OPB), a reference ontology of classical physics designed for annotating biophysical content of growing ..
  83. ncbi From cradle to grave: RNA biology in malaria parasites
    Katie R Hughes
    Division of Infection and Immunity, Faculty of Biomedical Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland, UK
    Wiley Interdiscip Rev RNA 1:287-303. 2010
    ..This review attempts to summarize what is currently known about the biology of Plasmodium RNA.
  84. pmc Regenerative chemical biology: current challenges and future potential
    Ada Ao
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232, USA
    Chem Biol 18:413-24. 2011
    ..Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy...
  85. ncbi Combining supramolecular chemistry with biology
    Dana A Uhlenheuer
    Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612AZ Eindhoven, The Netherlands
    Chem Soc Rev 39:2817-26. 2010
    ..Supramolecular chemistry has come full circle, studying the biology and its molecules which initially inspired its conception.
  86. ncbi Magnetic tweezers in cell biology
    Monica Tanase
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Methods Cell Biol 83:473-93. 2007
    ..One apparatus built in our laboratory is described in detail, along with examples of experimental applications and results...
  87. ncbi Biology, one molecule at a time
    Achillefs N Kapanidis
    Department of Physics and Interdisciplinary Research Collaboration in Bionanotechnology, Clarendon Laboratory, University of Oxford, Oxford, UK
    Trends Biochem Sci 34:234-43. 2009
    ..The single-molecule approach to biology offers distinct advantages over the conventional approach of taking bulk measurements; this additional ..
  88. pmc Adding a little reality to building ontologies for biology
    Phillip Lord
    School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 5:e12258. 2010
    Many areas of biology are open to mathematical and computational modelling. The application of discrete, logical formalisms defines the field of biomedical ontologies. Ontologies have been put to many uses in bioinformatics...
  89. ncbi George Emil Palade: charismatic virtuoso of cell biology
    Alan M Tartakoff
    Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Nat Rev Mol Cell Biol 3:871-6. 2002
    ..This focus on the logic of organelles defined a crucial turning point in biomedical science. The following article sketches Palade's research, as part of a larger community that flourished after the Second World War...
  90. ncbi Curious parallels and curious connections--phylogenetic thinking in biology and historical linguistics
    Quentin D Atkinson
    Department of Psychology, University of Auckland, Private Bag 92019, Auckland 1020, New Zealand
    Syst Biol 54:513-26. 2005
    ..of process, there are a number of equally curious parallels and connections between the development of methods in biology and historical linguistics...
  91. ncbi Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine
    Andrea D Weston
    Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103 8904, USA
    J Proteome Res 3:179-96. 2004
    The emergence of systems biology is bringing forth a new set of challenges for advancing science and technology...
  92. ncbi Covalent inhibitors of glycosidases and their applications in biochemistry and biology
    Brian P Rempel
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Glycobiology 18:570-86. 2008
    ....
  93. ncbi Multispectral imaging in biology and medicine: slices of life
    Richard M Levenson
    CRI Inc, Woburn, MA, USA
    Cytometry A 69:748-58. 2006
    ..In-vivo imaging is a rapidly growing field with applications in basic biology, drug discovery, and clinical medicine...
  94. ncbi Mechanisms, biology and inhibitors of deubiquitinating enzymes
    Kerry Routenberg Love
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Chem Biol 3:697-705. 2007
    ....
  95. ncbi The challenges and scope of theoretical biology
    David C Krakauer
    Santa Fe Institute, Santa Fe, NM, USA
    J Theor Biol 276:269-76. 2011
    ..In this respect biology resembles alternative model-rich frameworks, such as economics and engineering...
  96. ncbi In vivo cell biology: following the zebrafish trend
    Dimitris Beis
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 2711, USA
    Trends Cell Biol 16:105-12. 2006
    ..Although this model system has been predominantly appreciated for its amenability to forward genetics, current advances in imaging technology and an increasing number of transgenic lines are bringing it closer to its full potential...
  97. ncbi Chemical space and biology
    Christopher M Dobson
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nature 432:824-8. 2004
    ..Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs...
  98. ncbi The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases
    S Mahajan
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195 7610, USA
    Cell Mol Life Sci 62:1221-33. 2005
    ..However, design of isoform specificity remains a significant challenge in GST inhibitor development. Strategies for further inhibitor design and their possible limitations, along with potential therapeutic uses, are summarized...
  99. ncbi Navigating chemical space for biology and medicine
    Christopher Lipinski
    Pfizer Global R and D, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, USA
    Nature 432:855-61. 2004
    ..what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?..
  100. pmc Textpresso: an ontology-based information retrieval and extraction system for biological literature
    Hans Michael Muller
    Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA
    PLoS Biol 2:e309. 2004
    ..Textpresso can be accessed at http://www.textpresso.org or via WormBase at http://www.wormbase.org...
  101. ncbi Free radicals in biology and medicine: from inflammation to biotechnology
    Okezie I Aruoma
    Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London, UK
    Biofactors 27:1-3. 2006

Research Grants75

  1. Scientific Meeting: Mechanisms of Cell Death
    Zahra Zakeri; Fiscal Year: 2006
    ..including immunology, oncology, neurology, infectious diseases, cardiac infarct and stroke, reproductive biology, teratology, and environmental medicine...
  2. Genetics of Wing and Cell-Size Evolution in Nasonia
    John Werren; Fiscal Year: 2008
    How new morphologies evolve is a fundamental question in biology. Most morphological evolution involves changes in the size of organs, which is basically achieved in two ways, by changes in cell size and cell number...
  3. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  4. SIGNALING PATHWAYS INTERACTIONS AND MAMMARY TUMOR
    SRINIVAS RAVI IYENGAR; Fiscal Year: 2004
    ..abstract_text> ..
  5. STRUCTURE AND FUNCTION OF SIGNAL TRANSDUCING COMPONENTS
    SRINIVAS RAVI IYENGAR; Fiscal Year: 2008
    ..abstract_text> ..
  6. Perinatal Determinants of Intersensory Perception
    Robert Lickliter; Fiscal Year: 2009
    ..abstract_text> ..
  7. Multivalency: Mechanisms and Applications
    George M Whitesides; Fiscal Year: 2010
    ..It is a type of interaction that is ubiquitous in biology and biomedicine...
  8. CATENINS, EPITHELIAL BEHAVIOR AND GENE EXPRESSION
    Michael Klymkowsky; Fiscal Year: 2004
    ..We will test whether decreasing the expression of specific SOXs using anti-sense reagents leads to the predicted expansion of TCF regulated target genes and/or increased sensitivity of embryonic cells to Wnt signaling components ..
  9. PEPTIDE SYNTHESIZER
    Sherwin Wilk; Fiscal Year: 2001
    ..The instrument will be operated and maintained by Dr. Imre Wolf, an accomplished peptide chemist and instrumentation specialist who has operated the Mount Sinai Core facility Milligen peptide synthesizer. ..
  10. Capillary Electrophoresis and Protein Biophysics
    George M Whitesides; Fiscal Year: 2010
    ..used to separate, characterize, and manipulate proteins is broadly important in biochemistry and molecular biology: areas of application include proteomics and systems biology, purification of protein therapeutics, use in lab-on-..
  11. NFkB Targets and Neural Crest Development
    MICHAEL WILLIAM KLYMKOWSKY; Fiscal Year: 2010
    ..Together these observation should have important implications for understanding the behavior of molecular and inductive networks in general and the prevention and/or amelioration of neural crest defects in particular. ..
  12. Tools To Study Cell Motility and Ion Channels
    George Whitesides; Fiscal Year: 2006
    ..These projects are tied together by three common themes: motility, sensing, and new, microfabricated tools for biology/biochemistry. The work will have three broad outcomes...
  13. PERINATAL DETERMINANTS OF INTERSENSORY RESPONSIVENESS
    Robert Lickliter; Fiscal Year: 2004
    ..abstract_text> ..
  14. BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISM
    Sherwin Wilk; Fiscal Year: 2001
    ....
  15. Conference on Wiring and Plasticity of Nervous Systems
    Thomas Pollard; Fiscal Year: 2002
    ..We are confident that mutually beneficial insights will emerge from learning about each others work. ..
  16. Re-engineering the MEGA software package
    Sudhir Kumar; Fiscal Year: 2009
    ..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications.
  17. The Stem Cell Center at The Burnham Institute
    Evan Snyder; Fiscal Year: 2007
    ..Human Embryonic Stem Cells (hESC) have remarkable potential for studies of fundamental human developmental biology. The principal goal of this project is to establish the Burnham Stem Cell Center to facilitate collaborative ..
  18. Biophysiological Mechanisms of 'Heightened Speech'
    Katherine Verdolini; Fiscal Year: 2007
    ..The primary dependent variable is quality of life in relation to voice, measured with the Voice Handicap Index. Secondary variables are aerodynamic, laryngeal, and vocal quality measures. [unreadable] [unreadable]..
  19. Symposia on Electrophoretic BioMEMS for Proteomic, Genomic, and Cellular Applicat
    Adrienne Minerick; Fiscal Year: 2006
    ..costs have discouraged the involvement of additional researchers from industry and academia in the fields of biology, chemistry, medicine, biomedical engineering, and computational science...
  20. Spectrally resolved tomographic small-animal fluorescence imager
    Richard Levenson; Fiscal Year: 2007
    ..In addition, CRI will work on methods to accelerate time consuming tomographic reconstructions. Finally, easy-to-use software for control, display, quantitation and integration into laboratory information systems will be developed. ..
  21. RESEARCH RESOURCE FOR COMPLEX PHYSIOLOGIC SIGNALS
    ARY GOLDBERGER; Fiscal Year: 2006
    ..abstract_text> ..
  22. Cancer Resource--Pathology, Registry and Biorepositories
    Stuart Aaronson; Fiscal Year: 2006
    ..The availability of data on patient characteristics will be an invaluable resource for translational research using tumor and normal tissue and other biospecimens. ..
  23. STRUCTURAL ORGANIZATION AND PROTEOMICS OF TB
    Thomas Terwilliger; Fiscal Year: 2005
    ..The structural and functional information obtained in this project is to be placed in the public domain by timely deposition in publicly available databases. ..
  24. Combinations of genetic and environmental risk for externalization in adolescence
    ERIC NATHAN TURKHEIMER; Fiscal Year: 2010
    ....
  25. SECRETIONS OF ARTHROPODS
    Thomas Eisner; Fiscal Year: 2008
    ..Insects are major vectors of disease. An understanding of how insects depend on natural products for regulation of their biotic interactions is of broad applied significance to both medicine and agriculture. [unreadable] [unreadable]..
  26. New Synthetic Strategies for Protein Engineering
    Matthew B Francis; Fiscal Year: 2010
    ..In particular, the development of a metal carbene-based strategy for disulfide bonds will be explored as a means to modify antibody fragments and N-terminal methionine residues. ..
  27. WNT Receptor Signaling and Cancer
    Stuart Aaronson; Fiscal Year: 2009
    ..In summary, investigations within this project are directed toward establishing new insights into Wnt transforming mechanisms that may eventually lead to novel interventions with this pathway in human cancers. ..
  28. LINKING EARLY LINGUISTIC AND CONCEPTUAL DEVELOPMENT
    Sandra Waxman; Fiscal Year: 2009
    ..The results should have implications for theories of acquisition and may serve as a springboard for research on bilingualism and specific language impairments in young children. ..
  29. Peptide Hormone Structure Function
    Victor J Hruby; Fiscal Year: 2010
    ....
  30. STRUCTURE-BASED DESIGN PARADIGM:HIV Tat.PCAF INHIBITORS
    Ming Ming Zhou; Fiscal Year: 2008
    ..In this multidisciplinary Program Project Grant (PPG), we propose a multifaceted approach addressing the biology of HIV transcriptional activation to attain both mechanistic insight and the design of drugs targeting a specific ..
  31. Chemogenomic Analysis of E. coli Response to NO species
    James C Liao; Fiscal Year: 2010
    ..If hew TF targets are predicted, then the iteration continues. Otherwise, the predicted networks are verified using genetic and biochemical experiments. ..
  32. The Role of Neuronal Integration in Working Memory
    Eric R Kandel; Fiscal Year: 2010
    ..Such an understanding is not only important for the biology of memory storage, but is of great clinical importance as the organization of working memory processes is ..
  33. CELLULAR SENESCENCE IN AGING AND CANCER
    Stuart Aaronson; Fiscal Year: 2008
    ..Thus, we are poised to continue making important discoveries concerning the role of cellular senescence in aging and cancer. ..
  34. Extended Cardiac Preservation
    GREGORY FAHY; Fiscal Year: 2005
    ..Should that be the case, the combination product, URS with an intermittent perfusion system, will be tested with greater priority. ..
  35. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 2005
    ..Yeast has proven to be a useful experimental system to study vesicular trafficking and such may be true for the study of autophagy and its relationship to glycogen metabolism (aim iii). ..
  36. Synthesis & Characterization of a Tuberculosis Vaccine
    OBADIAH PLANTE; Fiscal Year: 2004
    ..The goal of this SBIR proposal will be to generate synthetic LAM-derived, glycolipid-based, molecules that can serve as potential TB vaccine candidates. ..
  37. Characterization of the DNA replication protein Sid2p
    Elizabeth Vallen; Fiscal Year: 2002
    ..Finally, the requirement for various checkpoint and repair pathways will be analyzed to determine the molecular basis of the defect in sid2 mutant cells. ..
  38. Hepatic engraftment of marrow cells in mice and humans
    Neil Theise; Fiscal Year: 2004
    ....
  39. MECHANISMS AND FUNCTIONS OF ASTROCYTE CALCIUM SIGNALING
    Andrew Charles; Fiscal Year: 2004
    ....
  40. Cell phenotype-controlled mechanical signaling of MSCs
    David Butler; Fiscal Year: 2004
    ..This technology can dramatically reduce time/expense during the development phase of TE fibrocartilage. ..
  41. Meeting: Mechanisms of Cell Death
    Zahra Zakeri; Fiscal Year: 2004
    ..including immunology, oncology, neurology, infectious diseases, cardiac infarct and stroke, reproductive biology, teratology, and environmental medicine...
  42. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  43. SOLID STATE NMR OF PEPTIDES
    STANLEY OPELLA; Fiscal Year: 2004
    ..In particular, we will compare the results obtained from a 79- residue globular protein to those from an 80-residue membrane protein. ..
  44. NMR STUDIES OF BIOLOGICAL SUPRAMOLECULAR STRUCTURES
    STANLEY OPELLA; Fiscal Year: 2003
    ..high-field solid-state NMR spectrometer dedicated to these studies, and recent developments in the molecular biology of filamentous bacteriophages, which enable them to display peptide sequences inserted into the major pVIII coat ..
  45. MOLECULAR BIOMECHANICS
    George Oster; Fiscal Year: 2004
    ..Results will be compared to data supplied by experimental collaborators and colleagues. Computer animations and other visual techniques will be used to present results in a broadly understandable manner. ..
  46. PERIOPERATIVE PAIN, IMMUNE FUNCTION, AND METASTASIS
    Gayle Page; Fiscal Year: 2001
    ....
  47. STRUCTURE/FUNCTION OF THE MAPK PHOSPHATASE--PAC1
    Ming Ming Zhou; Fiscal Year: 2003
    ..3. Investigate the catalytic mechanisms for phosphotyrosine and phosphothreonine hydrolysis by the PAC1 phosphatase, using NMR spectroscopy, mutagenesis, and enzyme kinetic studies. ..
  48. Automatic Liquid Handling System
    Ming Ming Zhou; Fiscal Year: 2005
    ..This screening facility as a part of the newly established Chemical Biology Center is created to meet the growing needs of a large number of MSSM's investigators to access and discover new ..
  49. STRUCTURAL UNDERSTANDING OF PHENYLKETONURIA (PKU)
    RAYMOND STEVENS; Fiscal Year: 2004
    ..However it is important to determine the three dimensional structure of the full-length enzyme in order to fully understand the complex regulatory, catalytic, and stability issues associated with this family of enzymes. ..
  50. Cornea Preservation by Vitrification
    GREGORY FAHY; Fiscal Year: 2004
    ..In phase III we will launch commercial products and services. ..
  51. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..We will perform laboratory studies of tolerance and preference to understand these anomalies. Our results may be relevant to understanding the origin of species in other animal groups, including humans. ..
  52. FORMATION, STRUCTURE AND FUNCTION IN HETEROCHROMATIN
    Sarah Elgin; Fiscal Year: 2002
    ....
  53. Small integrin-binding proteins and tumor progression
    Neal Fedarko; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Robotic Simulation: Tissue Function with In Vivo Motions
    David Butler; Fiscal Year: 2007
    ..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]..
  55. Structure and mechanism of the AMP-activated protein kinase
    Lawrence Shapiro; Fiscal Year: 2010
    ..Our preliminary results and the further work proposed will provide high-resolution structural information on AMPK, and should directly enable the rational design of AMPK-directed therapeutics. ..
  56. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2008
    ..The proposed research program plans to develop greater program expertise in molecular biology. Additionally, it proposes to add a new faculty with NIDA interests...
  57. Probing single proteins in nanofabricated bioenvironment
    Daniel Chiu; Fiscal Year: 2006
    ..Gaining a better understanding of the true in vivo activities of proteins inside cells is critical for developing new drugs that target these proteins for the treatment of devastating diseases. ..
  58. A Policy-Oriented History of Newborn Screening for PKU
    Diane Paul; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  59. Nanoparticles with Tailored Monolayers for DNA Transfection
    VINCENT ROTELLO; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Nucleic acid transfection is one of the most important tools in modern biology, and an emerging tool for biomedical applications...
  60. NMR STUDIES OF BIOLOGICAL SUPRAMOLECULAR STRUCTURES
    STANLEY OPELLA; Fiscal Year: 2007
    ..The peptide sequences under investigation extend the biological of the research to AIDS, malaria, influenza, and neurochemistry. ..
  61. Substrates for Mechanistic Studies of Cell Adhesion
    Milan Mrksich; Fiscal Year: 2004
    ..A third effort will use substrates presenting an array of hundreds of peptides to identify new ligands that are important in adhesion and migration. ..
  62. Inequality, social capital and health in Boliva
    William Leonard; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Acquisition of a Cryoprobe for an 800 MHz NMR Spectrometer
    STANLEY OPELLA; Fiscal Year: 2008
    ..the instrumentation will enhance NIH-supported projects in two principal areas of biomedical research: structural biology and marine natural products, which provide complementary routes to new drugs for the treatment of diseases...
  64. USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERS
    Jeffrey Gimble; Fiscal Year: 2002
    ..This has commercial application to orthopedic and periodontal surgical treatments of joint replacement, fracture repair, and bone resorption secondary to tooth decay...
  65. New bioreactor-based approach to stem cell/progenitor expansion for cell therapie
    Stephen Navran; Fiscal Year: 2008
    ..The first and most intensively studied aspect of stem cell biology are the mechanisms by which stem cells are transformed into cells with distinct physiological functions...
  66. Botannical Extract Library Screeninig with Human ADAS Cells
    Jeffrey Gimble; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  67. TOOLS FOR PUBLIC CONVERSATION ABOUT BEHAVIORAL GENETICS
    Erik Parens; Fiscal Year: 2001
    ....
  68. Effect of Estrogen on Radiation-induced Cataractogenesis
    JOSEPH DYNLACHT; Fiscal Year: 2005
    ..abstract_text> ..
  69. Total Synthesis of Chloriolin B and Chloriolin C
    JOSEPH READY; Fiscal Year: 2002
    ..This project will also introduce a new method for the asymmetric enantioselective synthesis of five-membered rings and demonstrate its usefulness in complex molecule synthesis. ..
  70. Expression Analysis of Prostate Cancer
    Phillip Febbo; Fiscal Year: 2006
    ..Although emerging technologies that broadly monitor cellular biology offer great promise in improving our ability to understand and predict CAP behavior, there remain significant ..
  71. Monolayer Protected Nanoparticles Flavoenzyme Models
    VINCENT ROTELLO; Fiscal Year: 2005
    ....
  72. Biomolecular Recognition Using Nanoparticle Receptors
    VINCENT ROTELLO; Fiscal Year: 2003
    ..We will also explore the recognition of cellular structures, and the use of this recognition for both imaging and therapeutic applications. ..