Genomes and Genes
Summary: One of the biological sciences concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
Publications230 found, 100 shown here
- Next-generation sequencing transforms today's biologyStephan C Schuster
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA
Nat Methods 5:16-8. 2008..However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years...
- The second wave of synthetic biology: from modules to systemsPriscilla E M Purnick
Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA
Nat Rev Mol Cell Biol 10:410-22. 2009Synthetic biology is a research field that combines the investigative nature of biology with the constructive nature of engineering...
- Systems biology: a brief overviewHiroaki Kitano
Sony Computer Science Laboratories, Inc, 3 14 13 Higashi Gotanda, Shinagawa, Tokyo 141 0022, Japan
Science 295:1662-4. 2002To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism...
- Differential network biologyTrey Ideker
Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA, USA
Mol Syst Biol 8:565. 2012....
- The biology of infertility: research advances and clinical challengesMartin M Matzuk
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
Nat Med 14:1197-213. 2008..Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care...
- The concept of allostasis in biology and biomedicineBruce S McEwen
Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
Horm Behav 43:2-15. 2003..If allostatic load is chronically high, then pathologies develop. Type 2 allostatic overload does not trigger an escape response, and can only be counteracted through learning and changes in the social structure...
- Cause and effect in biology revisited: is Mayr's proximate-ultimate dichotomy still useful?Kevin N Laland
School of Biology, University of St Andrews, St Andrews KY16 9TS, UK
Science 334:1512-6. 2011Fifty years ago, Ernst Mayr published a hugely influential paper on the nature of causation in biology, in which he distinguished between proximate and ultimate causes...
- Feature point tracking and trajectory analysis for video imaging in cell biologyI F Sbalzarini
Institute of Computational Science, ETH Zurich, 8092 Zurich, Switzerland
J Struct Biol 151:182-95. 2005..the automated detection and quantitative analysis of particle trajectories as recorded by video imaging in cell biology. The tracking process requires no a priori mathematical modeling of the motion, it is self-initializing, it ..
- Rho GTPases: biochemistry and biologyAron B Jaffe
MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom
Annu Rev Cell Dev Biol 21:247-69. 2005..networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division...
- Machine learning and its applications to biologyAdi L Tarca
PLoS Comput Biol 3:e116. 2007
- Important role of integrins in the cancer biologyR Rathinam
Department of Biochemistry and Molecular Biology, Stanley S Scott Cancer Center, LSU School of Medicine, 1901 Perdido Street, New Orleans, LA, 70112, USA
Cancer Metastasis Rev 29:223-37. 2010..Also, we highlight the importance of integrin-binding proteins in cell migration and mechanisms that operate in invasive cells, during breast cancer progression...
- Structural biology in fragment-based drug designChristopher W Murray
Astex Therapeutics Ltd, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom
Curr Opin Struct Biol 20:497-507. 2010..Here we examine the recent literature looking at how structural biology has been used in a variety of successful fragment-screening applications...
- Molecular simulations of protein dynamics: new windows on mechanisms in biologyGuy G Dodson
University of York, York YO10 5YW, UK
EMBO Rep 9:144-50. 2008..Here, we highlight some examples of such approaches that illustrate the current state and potential of the field of molecular simulation...
- Network structure and the biology of populationsRobert M May
Zoology Department, South Parks Road, Oxford University, Oxford, UK, OX1 3PS
Trends Ecol Evol 21:394-9. 2006..I offer caveats and opinionated comment about some excesses of enthusiasm and suggest some areas where these network ideas might find further application...
- Directing experimental biology: a case study in mitochondrial biogenesisMatthew A Hibbs
Lewis Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Princeton, New Jersey, United States of America
PLoS Comput Biol 5:e1000322. 2009..experimentally validated on a large scale, leaving many bioinformatic methods unproven and underutilized in the biology community...
- Ceramide synthases at the centre of sphingolipid metabolism and biologyThomas D Mullen
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Biochem J 441:789-802. 2012..manner, CerSs appear to regulate multiple aspects of sphingolipid-mediated cell and organismal biology. In the present review, we discuss the function of CerSs as critical regulators of sphingolipid metabolism, ..
- OMERO: flexible, model-driven data management for experimental biologyChris Allan
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
Nat Methods 9:245-53. 2012..OMERO's design and flexibility have enabled its use for light-microscopy, high-content-screening, electron-microscopy and even non-image-genotype data. OMERO is open-source software, available at http://openmicroscopy.org/...
- The virtual cell: an integrated modeling environment for experimental and computational cell biologyIon I Moraru
Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 3505, USA
Ann N Y Acad Sci 971:595-6. 2002
- Multi-scale modeling in biology: how to bridge the gaps between scales?Zhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Prog Biophys Mol Biol 107:21-31. 2011..modeling, as a computational approach, has been widely adopted by researchers in computational and systems biology. A key unsolved issue is how to represent appropriately the dynamical behaviors of a high-dimensional model of a ..
- Timing to perfection: the biology of central and peripheral circadian clocksUrs Albrecht
Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
Neuron 74:246-60. 2012..This review will highlight the relationship between clocks and metabolism, and describe how cues such as light, food, and reward mediate entrainment of the circadian system...
- Web API for biology with a workflow navigation systemYeondae Kwon
Laboratory for Research and Development of Biological Databases, Center for Information Biology and DNA Data Bank of Japan, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
Nucleic Acids Res 37:W11-6. 2009DNA Data Bank of Japan (DDBJ) provides Web-based systems for biological analysis, called Web APIs for biology (WABI). So far, we have developed over 20 SOAP services and several workflows that consist of a series of method invocations...
- State of the nation in data integration for bioinformaticsCarole Goble
School of Computer Science, University of Manchester, Oxford Road, Manchester M139PL, UK
J Biomed Inform 41:687-93. 2008..The paper expands on that talk. We attempt to place some perspective on past efforts, highlight the reasons for success and failure, and indicate some pointers to the future...
- Graph theory and networks in BiologyO Mason
Hamilton Institute, National University of Ireland, Maynooth, Co Kildare, Ireland
IET Syst Biol 1:89-119. 2007A survey of the use of graph theoretical techniques in Biology is presented...
- From physics to biology by extending criticality and symmetry breakingsG Longo
Informatique, CNRS et École Normale Supérieure, Paris et CREA, Polytechnique, France
Prog Biophys Mol Biol 106:340-7. 2011..We then introduce our ongoing theoretical analysis in biology and show that symmetries play a radically different role in this discipline, when compared to those in current ..
- Nanoscale interfaces to biologySunho Park
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Curr Opin Chem Biol 14:616-22. 2010Nanotechnology has held great promise for revolutionizing biology. The biological behavior of nanomaterials depends primarily on how they interface to biomolecules and their surroundings...
- The evolving biology and treatment of prostate cancerRussel S Taichman
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
J Clin Invest 117:2351-61. 2007..As the population ages and prostate cancer prevalence increases, challenges remain in the diagnosis of clinically relevant prostate cancer as well as the management of the metastatic and androgen-independent metastatic disease states...
- Transforming growth factor-beta : biology and clinical relevanceIsaac Yi Kim
Department of Urology, University of California at Irvine, Orange, CA 92868, USA
J Biochem Mol Biol 38:1-8. 2005..In this report, we will review these clinical implications of transforming growth factor-beta ...
- Bright ideas for chemical biologyLuke D Lavis
Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
ACS Chem Biol 3:142-55. 2008Small-molecule fluorescent probes embody an essential facet of chemical biology. Although numerous compounds are known, the ensemble of fluorescent probes is based on a modest collection of modular "core" dyes...
- The biology of epilepsy genesJeffrey L Noebels
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Annu Rev Neurosci 26:599-625. 2003..This review selects exemplary members of several gene families to illustrate principal categories of the disease and trace the biological pathways to epileptogenesis in the developing brain...
- Self-organization in cell biology: a brief historyEric Karsenti
Eric Karsenti is at the Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nat Rev Mol Cell Biol 9:255-62. 2008..Self-organization concepts that were first developed in chemistry and physics and then applied to various morphogenetic problems in biology over the past century are now beginning to be applied to the organization of the living cell.
- Clinical and therapeutical implications of EPC biology in atherosclerosisN Werner
Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Germany
J Cell Mol Med 10:318-32. 2006..In this review we focus on the role of circulating endothelial progenitor cells in endothelial cell repair mechanisms at the vascular wall and their potentially protective and therapeutic role in atherosclerotic disease...
- Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theoryFulvio Mazzocchi
Institute for Atmospheric Pollution, Consiglio Nazionale delle Ricerche, Monterotondo, Rome, Italy
EMBO Rep 9:10-4. 2008
- Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's diseaseKumar Sambamurti
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
Neuromolecular Med 1:1-31. 2002..The present review summarizes our current understanding of APP metabolism and function and their relationship to other proteins involved in AD...
- Modular cell biology: retroactivity and insulationDomitilla Del Vecchio
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
Mol Syst Biol 4:161. 2008..We introduce, in particular, a mechanism based on a phosphorylation-dephosphorylation cycle. This mechanism enjoys a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation reactions...
- Predictive accuracy of population viability analysis in conservation biologyB W Brook
Key Centre for Biodiversity and Bioresources, Department of Biological Sciences, Macquarie University, New South Wales, Australia
Nature 404:385-7. 2000Population viability analysis (PVA) is widely applied in conservation biology to predict extinction risks for threatened species and to compare alternative options for their management...
- Bioimage informatics for experimental biologyJason R Swedlow
Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
Annu Rev Biophys 38:327-46. 2009..advances in light microscopy with the result that multidimensional imaging has driven a revolution in modern biology. The development of new approaches of data acquisition is reported frequently, and yet the significant data ..
- We know too little about parasitoid wasp distributions to draw any conclusions about latitudinal trends in species richness, body size and biologyDonald L J Quicke
Department of Life Science, Imperial College London, Ascot, Berkshire, United Kingdom
PLoS ONE 7:e32101. 2012Much has been written about latitudinal trends in parasitoid diversity and biology, though it is widely recognised that they are a comparatively poorly known group...
- Recent insights into the biology and biomedical applications of Flock House virusP A Venter
Department of Molecular Biology, CB262, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Cell Mol Life Sci 65:2675-87. 2008..Finally, applications for FHV as an epitopepresenting system are described with particular reference to its recent use for the development of a novel anthrax antitoxin and vaccine...
- Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systemsCaleb J Bashor
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 2517, USA
Annu Rev Biophys 39:515-37. 2010..and the goal of predictively and quantitatively understanding its function is one of the next great challenges in biology. Much of what we know about the cell concerns its constituent parts, but to a great extent we have yet to decode ..
- Research on small genomes: implications for synthetic biologyLisa Klasson
Department of Molecular Evolution, Uppsala University, Uppsala, Sweden
Bioessays 32:288-95. 2010..Synthetic biology may ultimately enable researchers to make customized cell-specific organelles for the production and delivery of ..
- From cradle to grave: RNA biology in malaria parasitesKatie R Hughes
Division of Infection and Immunity, Faculty of Biomedical Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, Scotland, UK
Wiley Interdiscip Rev RNA 1:287-303. 2010..This review attempts to summarize what is currently known about the biology of Plasmodium RNA.
- Mammalian synthetic biology--from tools to therapiesDominique Aubel
Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
Bioessays 32:332-45. 2010Mammalian synthetic biology holds the promise of providing novel therapeutic strategies, and the first success stories are beginning to be reported...
- Physical properties of biological entities: an introduction to the ontology of physics for biologyDaniel L Cook
Department of Physiology and Biophysics, University of Washington, Seattle, Washington, USA
PLoS ONE 6:e28708. 2011..In this paper, we introduce the Ontology of Physics for Biology (OPB), a reference ontology of classical physics designed for annotating biophysical content of growing ..
- Error bars in experimental biologyGeoff Cumming
School of Psychological Science and 2Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia 3086
J Cell Biol 177:7-11. 2007..Different types of error bars give quite different information, and so figure legends must make clear what error bars represent. We suggest eight simple rules to assist with effective use and interpretation of error bars...
- An extended synthesis for evolutionary biologyMassimo Pigliucci
Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
Ann N Y Acad Sci 1168:218-28. 2009..I argue that evolutionary biology has never seen a paradigm shift, in the philosophical sense of the term, except when it moved from natural ..
- Biology using engineering tools: the negative feedback amplifierMarc R Birtwistle
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Republic of Ireland
Cell Cycle 10:2069-76. 2011..Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer...
- Combining supramolecular chemistry with biologyDana A Uhlenheuer
Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612AZ Eindhoven, The Netherlands
Chem Soc Rev 39:2817-26. 2010..Supramolecular chemistry has come full circle, studying the biology and its molecules which initially inspired its conception.
- Regenerative chemical biology: current challenges and future potentialAda Ao
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232, USA
Chem Biol 18:413-24. 2011..Small molecules can potentially relieve these problems at major junctions of stem cell biology and regenerative therapy...
- Magnetic tweezers in cell biologyMonica Tanase
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Methods Cell Biol 83:473-93. 2007..One apparatus built in our laboratory is described in detail, along with examples of experimental applications and results...
- Adding a little reality to building ontologies for biologyPhillip Lord
School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom
PLoS ONE 5:e12258. 2010Many areas of biology are open to mathematical and computational modelling. The application of discrete, logical formalisms defines the field of biomedical ontologies. Ontologies have been put to many uses in bioinformatics...
- Curious parallels and curious connections--phylogenetic thinking in biology and historical linguisticsQuentin D Atkinson
Department of Psychology, University of Auckland, Private Bag 92019, Auckland 1020, New Zealand
Syst Biol 54:513-26. 2005..of process, there are a number of equally curious parallels and connections between the development of methods in biology and historical linguistics...
- Structural biology and chemistry of the terpenoid cyclasesDavid W Christianson
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104 6323, USA
Chem Rev 106:3412-42. 2006
- Biology, one molecule at a timeAchillefs N Kapanidis
Department of Physics and Interdisciplinary Research Collaboration in Bionanotechnology, Clarendon Laboratory, University of Oxford, Oxford, UK
Trends Biochem Sci 34:234-43. 2009..The single-molecule approach to biology offers distinct advantages over the conventional approach of taking bulk measurements; this additional ..
- George Emil Palade: charismatic virtuoso of cell biologyAlan M Tartakoff
Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Nat Rev Mol Cell Biol 3:871-6. 2002..This focus on the logic of organelles defined a crucial turning point in biomedical science. The following article sketches Palade's research, as part of a larger community that flourished after the Second World War...
- Covalent inhibitors of glycosidases and their applications in biochemistry and biologyBrian P Rempel
Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Glycobiology 18:570-86. 2008....
- Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicineAndrea D Weston
Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103 8904, USA
J Proteome Res 3:179-96. 2004The emergence of systems biology is bringing forth a new set of challenges for advancing science and technology...
- Multispectral imaging in biology and medicine: slices of lifeRichard M Levenson
CRI Inc, Woburn, MA, USA
Cytometry A 69:748-58. 2006..In-vivo imaging is a rapidly growing field with applications in basic biology, drug discovery, and clinical medicine...
- Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human healthFilippos Ververidis
Laboratory of Plant Biochemistry and Biotechnology, Department of Plant Sciences, Technological Educational Institute of Crete, Heraklion, Crete, Greece
Biotechnol J 2:1214-34. 2007....
- Mechanisms, biology and inhibitors of deubiquitinating enzymesKerry Routenberg Love
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Chem Biol 3:697-705. 2007....
- In vivo cell biology: following the zebrafish trendDimitris Beis
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 2711, USA
Trends Cell Biol 16:105-12. 2006..Although this model system has been predominantly appreciated for its amenability to forward genetics, current advances in imaging technology and an increasing number of transgenic lines are bringing it closer to its full potential...
- Emergence of the chicken as a model organism: implications for agriculture and biologyD W Burt
Roslin Institute, Edinburgh, Midlothian EH25 9PS, United Kingdom
Poult Sci 86:1460-71. 2007..These advances are reviewed and their implications are discussed...
- The challenges and scope of theoretical biologyDavid C Krakauer
Santa Fe Institute, Santa Fe, NM, USA
J Theor Biol 276:269-76. 2011..In this respect biology resembles alternative model-rich frameworks, such as economics and engineering...
- Chemical space and biologyChristopher M Dobson
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Nature 432:824-8. 2004..Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs...
- Textpresso: an ontology-based information retrieval and extraction system for biological literatureHans Michael Muller
Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA
PLoS Biol 2:e309. 2004..Textpresso can be accessed at http://www.textpresso.org or via WormBase at http://www.wormbase.org...
- Free radicals in biology and medicine: from inflammation to biotechnologyOkezie I Aruoma
Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London, UK
Biofactors 27:1-3. 2006
- How to use individual differences to isolate functional organization, biology, and utility of visual functions; with illustrative proposals for stereopsisJeremy B Wilmer
SUNY State College of Optometry, Vision Sciences, 33 West 42nd Street, New York, NY 10036, USA
Spat Vis 21:561-79. 2008..I elaborate on the use of individual differences to gain insights into the three areas mentioned above (function, biology/environment, utility), in each case describing the approach advocated, presenting model examples from the ..
- Navigating chemical space for biology and medicineChristopher Lipinski
Pfizer Global R and D, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, USA
Nature 432:855-61. 2004..what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?..
- The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferasesS Mahajan
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195 7610, USA
Cell Mol Life Sci 62:1221-33. 2005..However, design of isoform specificity remains a significant challenge in GST inhibitor development. Strategies for further inhibitor design and their possible limitations, along with potential therapeutic uses, are summarized...
- Designing and encoding models for synthetic biologyLukas Endler
EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
J R Soc Interface 6:S405-17. 2009A key component of any synthetic biology effort is the use of quantitative models. These models and their corresponding simulations allow optimization of a system design, as well as guiding their subsequent analysis...
- Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicineRandolph M Nesse
Department of Psychiatry and Psychology, University of Michigan, Room 3018, East Hall, 530 Church Street, Ann Arbor, MI 48104, USA
Proc Natl Acad Sci U S A 107:1800-7. 2010New applications of evolutionary biology in medicine are being discovered at an accelerating rate, but few physicians have sufficient educational background to use them fully...
- A treasure trove for lipoprotein biologyAldons J Lusis
Nat Genet 40:129-30. 2008
- The past, the future and the biology of memory storageE R Kandel
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Philos Trans R Soc Lond B Biol Sci 354:2027-52. 1999....
- Fueling educational reform: Bio2010--biology for the futureKerry Brenner
Board on Life Sciences, National Research Council, 500 Fifth Street, N W, Washington, DC 20001, USA
Cell Biol Educ 2:85-6. 2003
- Cranial suture biology: from pathways to patient careBenjamin Levi
Hagey Laboratory of Pediatric Regenerative Medicine Research, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California 94305, USA
J Craniofac Surg 23:13-9. 2012..In this review, we discuss the development of the cranial vault and explain the basic science behind craniosynostosis in humans as well as in animal models and how these studies may lead to future advances in craniosynostosis treatments...
- Microscale technologies for tissue engineering and biologyAli Khademhosseini
Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 103:2480-7. 2006..discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology. Throughout this review, we will use specific examples where available and will provide trends and future ..
- Scientific illiteracy and the partisan takeover of biologyLiza Gross
PLoS Biol 4:e167. 2006
- Innovations in teaching undergraduate biology and why we need themWilliam B Wood
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
Annu Rev Cell Dev Biol 25:93-112. 2009..Their widespread adoption could have a major impact on the introductory training of biology students.
- The biology and diagnostic applications of plasma RNAY M Dennis Lo
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
Ann N Y Acad Sci 1022:135-9. 2004..development of robust extraction and quantification protocols for circulating RNA, new information regarding its biology and characteristics has been obtained...
- Toward a conceptual framework for biologySamuel M Scheiner
Division of Environmental Biology, National Science Foundation, Arlington, Virginia 22230, USA
Q Rev Biol 85:293-318. 2010..progresses faster when researchers operate within an explicit framework of concepts and theories, but currently biology has no explicit, overarching conceptual framework and few general theories...
- Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicineEmily L Que
Department of Chemistry, University of California, Berkeley, CA 94720, USA
Chem Soc Rev 39:51-60. 2010..and the life sciences offers a broad palette of opportunities for researchers with interests ranging from coordination chemistry and spectroscopy to supramolecular chemistry and molecular recognition to metals in biology and medicine.
- A multisolute osmotic virial equation for solutions of interest in biologyJ A W Elliott
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada T6G 2G6
J Phys Chem B 111:1775-85. 2007The osmotic virial equation was used to predict osmolalities of solutions of interest in biology. The second osmotic virial coefficients, Bi, account for the interactions between identical solute molecules...
- A versatile and efficient high-throughput cloning tool for structural biologyEric R Geertsma
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Biochemistry 50:3272-8. 2011..numbers of open reading frames into expression vectors are of critical importance for challenging structural biology projects...
- Categorical data analysis in experimental biologyBo Xu
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 348:3-11. 2010The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories...
- Liposomes in biology and medicineReto A Schwendener
Institute of Molecular Cancer Research, University of Zurich, Switzerland
Adv Exp Med Biol 620:117-28. 2007..Due to their versatility and vast body of known properties liposome-based formulations will continue to occupy a leading role among the large selection of emerging DDS...
- [Advances in plant proteomics. II. Application of proteome techniques to plant biology research]Song Lin Ruan
Plant Molecular Biology and Proteomics Lab, Institute of BiotechnologyHangzhou Academy of Agriculture Science, Hangzhou 310024, China
Yi Chuan 28:1633-48. 2006..The prospects of plant proteomics are discussed...
- On the growth of scientific knowledge: yeast biology as a case studyXionglei He
State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
PLoS Comput Biol 5:e1000320. 2009..These findings reveal collective human behaviors in scientific research and help design better strategies in future knowledge exploration...
- Popper, laws, and the exclusion of biology from genuine scienceDavid N Stamos
Department of Philosophy, York University, 4700 Keele St, North York, ON, Canada M3J 1P3
Acta Biotheor 55:357-75. 2007..It is then argued that biology arguably has no genuine laws of its own...
- Structure, biochemistry and biology of hepoxilins: an updateSantosh Nigam
Eicosanoid and Lipid Research Division and Centre for Experimental Gynecology and Breast Research, Charité University Medical Centre Benjamin Franklin, Berlin, Germany
FEBS J 274:3503-12. 2007..The present review gives an update on the biochemistry, biology and clinical aspects of hepoxilin-based drug development...
- The semantic web and biologyTor Kristian Jenssen
Dept of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
Drug Discov Today 7:992. 2002
- Protein structure databases with new web services for structural biology and biomedical researchDaron M Standley
Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
Brief Bioinform 9:276-85. 2008..Several applications have been developed at PDBj for structural biology and biomedical studies: (i) a Java-based molecular graphics viewer, jV; (ii) display of electron density maps for ..
- Pulp biology: progress during the past 25 yearsHenry O Trowbridge
University of Pennsylvania, USA
Aust Endod J 29:5-12. 2003....
- The application of low shear modeled microgravity to 3-D cell biology and tissue engineeringStephen Navran
Synthecon, Inc, 8042 El Rio, Houston, Texas 77054, USA
Biotechnol Annu Rev 14:275-96. 2008..become widely recognized that in vitro culture systems must become three dimensional to correctly model in vivo biology. Attempts to modify conventional 2-D culture technology to accommodate 3-D cell growth such as embedding cells in ..
- Returning to our roots: making plant biology research relevant to future challenges in agricultureSteven J Rothstein
Department of Molecularand Cellular Biology, University of Guelph, Guelph, ON, Canada
Plant Cell 19:2695-9. 2007
- Large-scale optimization-based classification models in medicine and biologyEva K Lee
Center for Operations Research in Medicine and HealthCare, School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0205, USA
Ann Biomed Eng 35:1095-109. 2007..In all these applications, the predictive model yields correct classification rates ranging from 80 to 100%. This provides motivation for pursuing its use as a medical diagnostic, monitoring and decision-making tool...
- From Darwinism to evolutionary biologyU Kutschera
Science 321:1157-8. 2008
- Symmetry breaking in biologyRong Li
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
Cold Spring Harb Perspect Biol 2:a003475. 2010..Symmetry breaking is essential for cell movement, polarity, and developmental patterning. Amplification of initial asymmetry is key to the conserved mechanisms involved...
- Biology and health inequalityEric Brunner
Departmentof Epidemiology and Public Health, University College London, London, United Kingdom
PLoS Biol 5:e267. 2007
- Claude Bernard and Judah Folkman: nothing makes sense in medicine except in the light of biologyGerald Weissmann
FASEB J 22:943-6. 2008
- Mathematics is biology's next microscope, only better; biology is mathematics' next physics, only betterJoel E Cohen
Laboratory of Populations, Rockefeller and Columbia Universities, New York, New York, USA
PLoS Biol 2:e439. 2004
- MicroRNAs from the Planarian Schmidtea mediterranea: a model system for stem cell biologyDasaradhi Palakodeti
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
RNA 12:1640-9. 2006..Planarians are therefore an excellent model system for studying many aspects of stem cell biology. Here we report the cloning and initial characterization of 71 miRNAs from the planarian Schmidtea mediterranea...
- Synthetic biology: engineering Escherichia coli to see lightAnselm Levskaya
Biophysics Program, University of California, San Francisco, California 94143, USA
Nature 438:441-2. 2005..This spatial control of bacterial gene expression could be used to 'print' complex biological materials, for example, and to investigate signalling pathways through precise spatial and temporal control of their phosphorylation steps...
Research Grants170 found, 100 shown here
- STRUCTURE AND FUNCTION OF SIGNAL TRANSDUCING COMPONENTSSRINIVAS RAVI IYENGAR; Fiscal Year: 2007..abstract_text> ..
- Genetics of Wing and Cell-Size Evolution in NasoniaJohn Werren; Fiscal Year: 2007How new morphologies evolve is a fundamental question in biology. Most morphological evolution involves changes in the size of organs, which is basically achieved in two ways, by changes in cell size and cell number...
- Spectrum: Building Pathways to Biomedical Research Careers for Girls and Women oKimberly Tanner; Fiscal Year: 2007The Science Education Partnership and Assessment Laboratory (SEPAL) in the Department of Biology at San Francisco State University (SFSU) - in strong collaboration with the San Francisco Unified School District (SFUSD), the ..
- BIOACTIVATION OF HALOGENATED HYDROCARBONSF Guengerich; Fiscal Year: 2005..These experiments involving enzymatic oxidation and conjugation reactions are intended to help define important concepts that can be applied to other halogenated hydrocarbons and to other cancer suspect chemicals as well. ..
- Polymerase Interactions with Carcinogen-modified DNAF Guengerich; Fiscal Year: 2007..The overall goal is understanding molecular mechanisms of mutagenesis and relevance to chemical carcinogenesis. ..
- BIOACTIVATION OF HALOGENATED HYDROCARBONSF Peter Guengerich; Fiscal Year: 2010..abstract_text> ..
- Polymerase Interactions with Carcinogen-modified DNAF Peter Guengerich; Fiscal Year: 2010..The goals of this project involve understanding how the DNA polymerases make such mistakes. ..
- POLYMERASE INTERACTIONS WITH CARCINOGEN MODIFIED DNAF Guengerich; Fiscal Year: 2004..The overall goal is understanding molecular mechanisms of mutagenesis as a part of chemical carcinogenesis. ..
- Metabolism of Carcinogens and Drugs by Human P450sF Guengerich; Fiscal Year: 2007....
- STRUCTURE/FUNCTION OF SIGNAL TRANSDUCING COMPONENTSSRINIVAS RAVI IYENGAR; Fiscal Year: 2003..It is anticipated that these studies will lead to the identification of key intracellular sites that are potential targets for therapeutic agents that have their effects by modulation of G protein signaling pathways. ..
- SIGNALING PATHWAYS INTERACTIONS AND MAMMARY TUMORSRINIVAS RAVI IYENGAR; Fiscal Year: 2004..abstract_text> ..
- Functions of Regulatory Motifs in Signaling NetworksSRINIVAS RAVI V IYENGAR; Fiscal Year: 2010..We plan to use a systems biology approach to study how subunits of heterotrimeric Gi/o trigger neurite outgrowth in the Neuro-2A cell line and ..
- Dynamics Underlying Tissue IntegritySusana R Neves; Fiscal Year: 2010..We will use the filtration barrier of the kidney cortex as our model system. We will use a combination of mathematical models and engineering approaches to develop a 3D tissue assembly. ..
- MECHANISMS OF INTERACTION BETWEEN SIGNALING PATHWAYSSRINIVAS RAVI IYENGAR; Fiscal Year: 2007..From these studies we anticipate that we will develop a predictive understanding of how the cannabinoid and Galphao regulated signaling network triggers neurite extension. ..
- Modeling Cell Regulatory NetworksSRINIVAS RAVI IYENGAR; Fiscal Year: 2009..From such analysis we hope to define the key criteria involved in determining the characteristics of microdomains of signaling molecules within the cell. ..
- MECHANISMS OF INTERACTION BETWEEN SIGNALING PATHWAYSSRINIVAS RAVI IYENGAR; Fiscal Year: 2002..We anticipate that the proposed studies should provide new insights into how G protein coupling to other signal pathways can be used to evoke biological effects. ..
- STRUCTURE/FUNCTION OF SIGNAL TRANSDUCING COMPONENTSSRINIVAS RAVI IYENGAR; Fiscal Year: 1999..Such understanding could lead to new long acting therapeutic agents for many diseases. ..
- Capillary Electrophoresis and Protein BiophysicsGeorge Whitesides; Fiscal Year: 2007..used to separate, characterize, and manipulate proteins is broadly important in biochemistry and molecular biology: areas of application include proteomics and systems biology, purification of protein therapeutics, use in lab-on-..
- Re-engineering the MEGA software packageSudhir Kumar; Fiscal Year: 2009..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications.
- Inequality, social capital and health in BolivaWilliam Leonard; Fiscal Year: 2007....
- Molecular Imaging of G-Protein-Coupled Receptors for Drug DevelopmentSTANLEY OPELLA; Fiscal Year: 2007..This research will be multidisciplinary, involving synthetic organic chemistry, molecular biology, structural biology, NMR spectroscopy, and computer calculations...
- NMR STUDIES OF BIOLOGICAL SUPRAMOLECULAR STRUCTURESSTANLEY OPELLA; Fiscal Year: 2007..The peptide sequences under investigation extend the biological of the research to AIDS, malaria, influenza, and neurochemistry. ..
- Human Breast Cancer Stem Cell SurrogatesWENDY A contact WOODWARD; Fiscal Year: 2010..This approach could be used to select patients for individualized therapy using targeted sensitizing agents based on the proposed preclinical studies. ..
- Cognitive Functions Linked to Frontal LobeAdele Diamond; Fiscal Year: 2007..Insights into the conditions under which children can succeed may yield procedures that might prove helpful to those afflicted with disorders affecting these critical functions. ..
- Old Westbury Neuroscience Research Institute MIDARPGeorge Stefano; Fiscal Year: 2007..The proposed research program plans to develop greater program expertise in molecular biology. Additionally, it proposes to add a new faculty with NIDA interests...
- Structure and mechanism of the AMP-activated protein kinaseLawrence Shapiro; Fiscal Year: 2010..Our preliminary results and the further work proposed will provide high-resolution structural information on AMPK, and should directly enable the rational design of AMPK-directed therapeutics. ..
- NFkB Targets and Neural Crest DevelopmentMichael Klymkowsky; Fiscal Year: 2009..Together these observation should have important implications for understanding the behavior of molecular and inductive networks in general and the prevention and/or amelioration of neural crest defects in particular. ..
- Single-Molecule Studies of Synaptic VesiclesDaniel Chiu; Fiscal Year: 2009....
- Computational Analysis of Gene Expression Pattern ImagesSudhir Kumar; Fiscal Year: 2009..will fulfill the day-to-day needs of basic and applied researchers as well as students in many areas of molecular biology crucial in human health research, including computational genomics, molecular genetics, developmental biology, ..
- MOLECULAR BASIS OF CADHERIN MEDIATED CELL ADHESIONLawrence Shapiro; Fiscal Year: 2010....