neuronal plasticity

Summary

Summary: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.

Top Publications

  1. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
  2. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
  3. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
  4. ncbi The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
  5. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
  6. ncbi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
  7. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
  8. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies (Sokendai, Myodaiji, Okazaki 444-8787, Japan
    Nature 429:761-6. 2004
  9. ncbi Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
  10. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002

Research Grants

  1. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2010
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
  3. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
  4. EFFECTS OF APOE ON OLFACTORY NEURON PLASTICITY IN MICE
    Britto Nathan; Fiscal Year: 2005
  5. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
  6. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2010
  7. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
  8. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2010
  9. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
  10. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007

Detail Information

Publications270 found, 100 shown here

  1. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
    ..Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function...
  2. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
    ..With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior...
  3. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  4. ncbi The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
    ..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
  5. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
    ....
  6. ncbi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
    ..This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions...
  7. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
    ..Finally, we summarize the recent literature on putative molecular players in synaptic plasticity and the effects of genetic manipulations and other modulatory influences...
  8. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies (Sokendai, Myodaiji, Okazaki 444-8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  9. ncbi Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  10. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  11. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
  12. ncbi An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  13. ncbi Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species...
  14. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity...
  15. ncbi Neuronal signalling of fear memory
    Stephen Maren
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 5:844-52. 2004
    ..Understanding the signalling of aversive memory by amygdala neurons opens new avenues for research into the neural systems that support fear behaviour...
  16. ncbi The organization of recent and remote memories
    Paul W Frankland
    Program in Integrative Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1XB
    Nat Rev Neurosci 6:119-30. 2005
    ..However, recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation...
  17. ncbi The mystery and magic of glia: a perspective on their roles in health and disease
    Ben A Barres
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 60:430-40. 2008
    ..I argue that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly...
  18. ncbi Motor learning: its relevance to stroke recovery and neurorehabilitation
    John W Krakauer
    Stroke and Critical Care Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York NY, USA
    Curr Opin Neurol 19:84-90. 2006
    ..questions: (i) What is motor learning? (ii) Do patients with hemiparesis have a learning deficit? (iii) Is recovery after injury a form of motor learning? (iv) Are approaches based on motor learning principles useful for rehabilitation?..
  19. ncbi Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  20. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  21. ncbi The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..its transcriptional and translational regulation, the functions of the Arc protein in multiple forms of neuronal plasticity [long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity], and its broader ..
  22. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ....
  23. ncbi Theta burst stimulation of the human motor cortex
    Ying-Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
    ....
  24. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  25. ncbi MAPK cascade signalling and synaptic plasticity
    Gareth M Thomas
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB 904, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Rev Neurosci 5:173-83. 2004
  26. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  27. ncbi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  28. ncbi Unraveling mechanisms of homeostatic synaptic plasticity
    Karine Pozo
    MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 66:337-51. 2010
    ..Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity...
  29. ncbi Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
    Lorenzo A Cingolani
    MRC Laboratory for Molecular Cell Biology and MRC Cell Biology Unit, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Rev Neurosci 9:344-56. 2008
    ..The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function...
  30. ncbi Local GABA circuit control of experience-dependent plasticity in developing visual cortex
    T K Hensch
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 282:1504-8. 1998
    ..Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development...
  31. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat...
  32. ncbi Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
    Daniela Carulli
    Cambridge University Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 133:2331-47. 2010
    ..The organization of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the control of central nervous system plasticity by the extracellular matrix...
  33. ncbi Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    Hsiao Tuan Chao
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 468:263-9. 2010
    ..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
  34. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ....
  35. ncbi Stress and hippocampal plasticity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Annu Rev Neurosci 22:105-22. 1999
    ..It is important, from a therapeutic standpoint, to distinguish between a permanent loss of cells and a reversible atrophy...
  36. ncbi Dendritic protein synthesis, synaptic plasticity, and memory
    Michael A Sutton
    Division of Biology 114-96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Cell 127:49-58. 2006
    ..Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area...
  37. ncbi Polychronization: computation with spikes
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Neural Comput 18:245-82. 2006
    ..quot;..
  38. ncbi Stably maintained dendritic spines are associated with lifelong memories
    Guang Yang
    Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Nature 462:920-4. 2009
    ..These studies indicate that learning and daily sensory experience leave minute but permanent marks on cortical connections and suggest that lifelong memories are stored in largely stably connected synaptic networks...
  39. ncbi Adaptive exponential integrate-and-fire model as an effective description of neuronal activity
    Romain Brette
    Dept d Informatique, Equipe Odyssée, Ecole Normale Superieure, 45 rue d Ulm, 75230 Paris Cedex 05, France
    J Neurophysiol 94:3637-42. 2005
    ..These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro...
  40. ncbi Spike timing-dependent plasticity of neural circuits
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
    Neuron 44:23-30. 2004
    ..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule...
  41. ncbi Structural dynamics of dendritic spines in memory and cognition
    Haruo Kasai
    Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, and Center for NanoBio Integration, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Trends Neurosci 33:121-9. 2010
    ..Thus, spine dynamics are cellular phenomena with important implications for cognition and memory. Furthermore, impaired spine dynamics can cause psychiatric and neurodevelopmental disorders...
  42. ncbi Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
    Ken ichi Okamoto
    RIKEN MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:1104-12. 2004
    ..This bidirectional regulation of actin is actively involved in protein assembly and disassembly and provides a substrate for bidirectional synaptic plasticity...
  43. ncbi Enriched environments, experience-dependent plasticity and disorders of the nervous system
    Jess Nithianantharajah
    Howard Florey Institute, National Neuroscience Facility, University of Melbourne, Victoria 3010, Australia
    Nat Rev Neurosci 7:697-709. 2006
    ..Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications...
  44. ncbi Decoding the epigenetic language of neuronal plasticity
    Emiliana Borrelli
    Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
    Neuron 60:961-74. 2008
    ....
  45. ncbi A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex
    Ming Gao
    Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 30:7168-78. 2010
    ..1 KOs. Our results demonstrate that Arc/Arg3.1 plays a selective role in regulating visual experience-dependent homeostatic plasticity of excitatory synaptic transmission in vivo...
  46. ncbi Local, persistent activation of Rho GTPases during plasticity of single dendritic spines
    Hideji Murakoshi
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Nature 472:100-4. 2011
    ..RhoA and Cdc42 activation depended on Ca(2+)/calmodulin-dependent kinase (CaMKII). Thus, RhoA and Cdc42 relay transient CaMKII activation to synapse-specific, long-term signalling required for spine structural plasticity...
  47. ncbi Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    J S Snyder
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 85:2423-31. 2001
    ..Since DG is the major source of the afferent inputs into the hippocampus, the production and the plasticity of new neurons may have an important role in the hippocampal functions such as learning and memory...
  48. ncbi Exercise: a behavioral intervention to enhance brain health and plasticity
    Carl W Cotman
    Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    Trends Neurosci 25:295-301. 2002
    ..Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity...
  49. ncbi Solving the distal reward problem through linkage of STDP and dopamine signaling
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 17:2443-52. 2007
    ..This study emphasizes the importance of precise firing patterns in brain dynamics and suggests how a global diffusive reinforcement signal in the form of extracellular DA can selectively influence the right synapses at the right time...
  50. ncbi Balancing structure and function at hippocampal dendritic spines
    Jennifer N Bourne
    Center for Learning and Memory, Department of Neurobiology, University of Texas, Austin, Texas 78712 0805, USA
    Annu Rev Neurosci 31:47-67. 2008
    ..Key to this endeavor is having sufficient resolution to determine the extrinsic factors (such as perisynaptic astroglia) and the intrinsic factors (such as core subcellular organelles) that are required to build and maintain synapses...
  51. ncbi Rapid formation and selective stabilization of synapses for enduring motor memories
    Tonghui Xu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nature 462:915-9. 2009
    ..Our findings reveal that rapid, but long-lasting, synaptic reorganization is closely associated with motor learning. The data also suggest that stabilized neuronal connections are the foundation of durable motor memory...
  52. ncbi Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    ..Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength...
  53. ncbi Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
    Moustapha Cisse
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    Nature 469:47-52. 2011
    ..Thus, depletion of EphB2 is critical in amyloid-β-induced neuronal dysfunction. Increasing EphB2 levels or function could be beneficial in Alzheimer's disease...
  54. ncbi Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I
    Dale A Fortin
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 30:11565-75. 2010
    ..Together, our results suggest that synaptic recruitment of CP-AMPARs via CaMKI may provide a mechanistic link between NMDAR activation in LTP and regulation of a signaling pathway that drives spine enlargement via actin polymerization...
  55. ncbi Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
    Zhong Wu Liu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:8671-5. 2010
    ..Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep...
  56. ncbi Synaptic computation
    L F Abbott
    Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nature 431:796-803. 2004
    ..By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates...
  57. ncbi Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  58. ncbi Perineuronal nets protect fear memories from erasure
    Nadine Gogolla
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Science 325:1258-61. 2009
    ..This result indicates that intact PNNs mediate the formation of erasure-resistant fear memories and identifies a molecular mechanism closing a postnatal critical period during which traumatic memories can be erased by extinction...
  59. ncbi Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
    ..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy.
  60. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  61. ncbi The stressed hippocampus, synaptic plasticity and lost memories
    Jeansok J Kim
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520 8205, USA
    Nat Rev Neurosci 3:453-62. 2002
    ..Here, we provide an overview of the neurobiology of stress memory interactions, and present a neural endocrine model to explain how stress modifies hippocampal functioning...
  62. ncbi Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
    Takeo Saneyoshi
    Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Curr Opin Neurobiol 20:108-15. 2010
    ..Owing to space limitations, it will focus on mammalian excitatory (i.e. glutamatergic) synapses and will not consider several activity-independent signaling pathways (e.g. ephrinB receptor) that also modulate spine and synapse formation...
  63. ncbi The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    J M Bessa
    Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Mol Psychiatry 14:764-73, 739. 2009
    ..Instead, our experiments suggest re-establishment of neuronal plasticity (dendritic remodeling and synaptic contacts) in the hippocampus and prefrontal cortex, rather than ..
  64. ncbi Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  65. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  66. ncbi Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
  67. ncbi Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
    J Neurosci 27:6128-40. 2007
    ..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex...
  68. ncbi Adaptation to synaptic inactivity in hippocampal neurons
    Tara C Thiagarajan
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Neuron 47:725-37. 2005
    ..These results extend beyond "synaptic homeostasis" to involve more profound changes that can be better described as "metaplasticity"...
  69. ncbi Spatial learning depends on both the addition and removal of new hippocampal neurons
    David Dupret
    INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France
    PLoS Biol 5:e214. 2007
    ..In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons...
  70. ncbi Neural consequences of environmental enrichment
    H van Praag
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Rev Neurosci 1:191-8. 2000
    b>Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans...
  71. ncbi Inhibitory threshold for critical-period activation in primary visual cortex
    M Fagiolini
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, Saitama, Japan
    Nature 404:183-6. 2000
    ..A threshold level of inhibition within the visual cortex may thus trigger, once in life, an experience-dependent critical period for circuit consolidation, which may otherwise lie dormant...
  72. ncbi Altered synaptic plasticity in a mouse model of fragile X mental retardation
    Kimberly M Huber
    Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 99:7746-50. 2002
    ..This finding indicates that FMRP plays an important functional role in regulating activity-dependent synaptic plasticity in the brain and suggests new therapeutic approaches for fragile X syndrome...
  73. ncbi Synaptic plasticity: taming the beast
    L F Abbott
    Department of Biology and Volen Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 3:1178-83. 2000
    ..We review three of them-synaptic scaling, spike-timing dependent plasticity and synaptic redistribution-and discuss their functional implications...
  74. ncbi Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity
    Melanie A Woodin
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 39:807-20. 2003
    ..Thus, GABAergic synapses can detect and be modified by coincident pre- and postsynaptic spiking, allowing the level of inhibition to be modulated in accordance to the temporal pattern of postsynaptic excitation...
  75. ncbi PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
    Jose A Esteban
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 6:136-43. 2003
    ..Thus, PKA phosphorylation of AMPA receptor subunits contributes to diverse mechanisms underlying synaptic plasticity...
  76. ncbi Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses
    Grant R J Gordon
    Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
    Neuron 64:391-403. 2009
    ..These data provide evidence for a form of distributed synaptic plasticity that is feed-forward, expressed quickly, and mediated by the synaptic activation of neighboring astrocytes...
  77. ncbi Dendritic spine formation and stabilization
    Yoshihiro Yoshihara
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Curr Opin Neurobiol 19:146-53. 2009
    ..Together these new data provide a better understanding of the mechanisms, speed and steps leading to the establishment of a stable excitatory synapse...
  78. ncbi Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
    William Ju
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 7:244-53. 2004
    ....
  79. ncbi A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation
    Sourav Banerjee
    Neuroscience Research Institute and Department of Cellular Molecular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Neuron 64:871-84. 2009
    ..We established this protein synthesis to be MOV10 and proteasome dependent. These results suggest a unifying picture of a local translational regulatory mechanism during synaptic plasticity...
  80. ncbi Polysialic acid in the plasticity of the developing and adult vertebrate nervous system
    Urs Rutishauser
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Neurosci 9:26-35. 2008
    ..The ability of PSA to increase the plasticity of neural cells is being exploited to improve the repair of adult CNS tissue...
  81. ncbi Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    Jason D Shepherd
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 52:475-84. 2006
    ..1 is required for memory consolidation, reveal the importance of Arc/Arg3.1's dynamic expression as it exerts continuous and precise control over synaptic strength and cellular excitability...
  82. ncbi Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
    Sayaka Sugiyama
    Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Cell 134:508-20. 2008
    ..Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit...
  83. ncbi Actin in dendritic spines: connecting dynamics to function
    Pirta Hotulainen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Cell Biol 189:619-29. 2010
    ..Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory...
  84. ncbi Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
    Anatol C Kreitzer
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 445:643-7. 2007
    ..These findings have implications for understanding the normal functions of the basal ganglia, and also suggest approaches for the development of therapeutic drugs for the treatment of striatal-based brain disorders...
  85. ncbi A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King's College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
    ..These results suggest a new role for adult neurogenesis in the formation and/or consolidation of long-term, hippocampus-dependent, spatial memories...
  86. ncbi Synaptic theory of working memory
    Gianluigi Mongillo
    Group for Neural Theory, Departement d Etudes Cognitives, Ecole Normale Supérieure et Collège de France, Paris, France
    Science 319:1543-6. 2008
    ..The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network...
  87. ncbi The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines
    Naoki Honkura
    Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 57:719-29. 2008
    ..Ca2+/calmodulin-dependent protein kinase II regulated this confinement. Thus, spines have an elaborate mechanical nature that is regulated by actin fibers...
  88. ncbi Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB
    Priyamvada Rajasethupathy
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 63:803-17. 2009
    ..We therefore present direct evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous system...
  89. ncbi Neuronal competition and selection during memory formation
    Jin Hee Han
    Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Science 316:457-60. 2007
    ..Our results suggest a competitive model underlying memory formation, in which eligible neurons are selected to participate in amemorytrace as a function of their relative CREB activity at the time of learning...
  90. ncbi Experience-dependent reactivation of ocular dominance plasticity in the adult visual cortex
    Laura Baroncelli
    CNR Neuroscience Institute, Via Moruzzi 1, I 56100, Pisa, Italy
    Exp Neurol 226:100-9. 2010
    ..The non-invasive nature of EE makes this paradigm particularly eligible for clinical application...
  91. ncbi Reversing neurodevelopmental disorders in adults
    Dan Ehninger
    Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095 1761, USA
    Neuron 60:950-60. 2008
    ..These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders...
  92. ncbi Activity-dependent structural plasticity
    Markus Butz
    Bernstein Center for Computational Neuroscience, Universitat Gottingen, Bunsenstr 10, 37073 Gottingen, Germany
    Brain Res Rev 60:287-305. 2009
    ..Understanding the principles of neural network reorganization on a structural level is relevant for a deeper understanding of long-term memory formation as well as for the treatment of neurological diseases such as stroke...
  93. ncbi Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
    Guilherme Neves
    Division of Neurophysiology, Medical Research Council National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Nat Rev Neurosci 9:65-75. 2008
    ..In the process, the hypothesis that synaptic plasticity is necessary and sufficient for information storage in the brain may finally be validated...
  94. ncbi Dopamine-mediated regulation of corticostriatal synaptic plasticity
    Paolo Calabresi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy
    Trends Neurosci 30:211-9. 2007
    ..Finally, we discuss how endogenous dopamine crucially influences changes in synaptic plasticity induced by pathological stimuli, such as energy deprivation...
  95. ncbi Spike timing dependent plasticity finds the start of repeating patterns in continuous spike trains
    Timothée Masquelier
    Centre de Recherche Cerveau et Cognition, Université Toulouse 3, Centre National de la Recherche Scientifique CNRS, Faculte de Medecine de Rangueil, Toulouse, France
    PLoS ONE 3:e1377. 2008
    ..STDP thus enables some form of temporal coding, even in the absence of an explicit time reference. Given that the mechanism exposed here is simple and cheap it is hard to believe that the brain did not evolve to use it...
  96. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    ..This model integrates known signal transduction pathways of hyperalgesia without contradiction...
  97. ncbi Experience leaves a lasting structural trace in cortical circuits
    Sonja B Hofer
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Nature 457:313-7. 2009
    ..These results provide a strong link between functional plasticity and specific synaptic rearrangements, revealing a mechanism of how prior experiences could be stored in cortical circuits...
  98. ncbi Perceptual learning directs auditory cortical map reorganization through top-down influences
    Daniel B Polley
    W M Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143 0732, USA
    J Neurosci 26:4970-82. 2006
    ..Top-down inputs might confer the selectivity necessary to modify a single feature representation without affecting other spatially organized feature representations embedded within the same neural circuitry...
  99. ncbi Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat
    R A Swain
    Department of Psychology, University of Illinois, 61801, Urbana, IL, USA
    Neuroscience 117:1037-46. 2003
    ..These changes are chronic and observable even in the anesthetized animal and are measurable using noninvasive techniques...
  100. ncbi Extensive cortical rewiring after brain injury
    Numa Dancause
    Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosci 25:10167-79. 2005
    ..Our results reveal an extraordinary anatomical rewiring capacity in the adult CNS after injury that may potentially play a role in recovery...
  101. ncbi Improving the performance of the amblyopic visual system
    Dennis M Levi
    School of Optometry and The Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 2020, USA
    Philos Trans R Soc Lond B Biol Sci 364:399-407. 2009
    ..These findings, along with the results of new clinical trials, suggest that it might be time to reconsider our notions about neural plasticity in amblyopia...

Research Grants87

  1. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2010
    ..expand ongoing activities under the Parent Grant to define the mechanistic relationships between neuronal plasticity and spinal immune activation in chronic pain in the spine...
  2. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  3. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...
  4. EFFECTS OF APOE ON OLFACTORY NEURON PLASTICITY IN MICE
    Britto Nathan; Fiscal Year: 2005
    ..One possible mechanism of apoE involvement in AD may be on the process involved with neuronal plasticity. Consistent with this proposed function, our in vitro studies have demonstrated that cortical neurons grown ..
  5. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
    ..the relative importance of mucosal or neuronal sources of 5-HT in enteric neuroprotection, neurogenesis, neuronal plasticity and inflammation...
  6. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2010
    ..the relative importance of mucosal or neuronal sources of 5-HT in enteric neuroprotection, neurogenesis, neuronal plasticity and inflammation...
  7. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  8. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2010
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  9. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  10. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007
    ..pattern of interconnections, which underlie behavior and, (3) the molecular basis of synapse-specific neuronal plasticity and neuronal growth...
  11. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2007
    ..A better understanding of the post-lesion reorganization of the somatosensory pathways is needed if patients with avulsed spinal dorsal roots are to be treated more effectively. ..
  12. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  13. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2010
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  14. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MC CARSON; Fiscal Year: 2004
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  15. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2011
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  16. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
    ..Regulation of neurotransmitter receptor efficacy and control of neuronal plasticity, as evidenced in receptor desensitization and chronic down-regulation mechanisms, are recognized as part of ..
  17. TRANS-SYNAPTIC SIGNALING DURING NEUROMUSCULAR DEVELOPMENT
    Graeme W Davis; Fiscal Year: 2010
    ..nervous system, NF-kB signaling system has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. At the neuromuscular junction, activation of NF-kB has been implicated in the mechanisms of muscle wasting ..
  18. Neuronal plasticity and cerebellar circuitry
    NEAL BARMACK; Fiscal Year: 2009
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  19. Neuronal plasticity and cerebellar circuitry
    Neal H Barmack; Fiscal Year: 2010
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  20. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2010
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  21. ACC Sensitization in Visceral Hypersensitive Rats
    Ying Li; Fiscal Year: 2007
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  22. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA GILLANI; Fiscal Year: 2007
    ..pyramidal cells, and layer V pyramidal cells) of Golgi-Cox processed brains will be examined for structural neuronal plasticity by quantification of dendritic arborization, spine density, and spine morphology...
  23. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY & AGING
    Carol Barnes; Fiscal Year: 1999
    ..The strength of this interaction is the ability to combine and apply the most powerful available methods to test the hypotheses under study, which could not be accomplished in either laboratory in isolation. ..
  24. Gonadotropin involvement in cognition and Alzheimer's disease: Therapeutic Implic
    Gemma Casadesus; Fiscal Year: 2010
    Estrogen is thought to play an important role in age-related cognitive decline, neuronal plasticity, as well as the pathogenesis of Alzheimer disease (AD)...
  25. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2010
    ..Thus, increased knowledge of the actions of dopamine and adenosine in the retina may aid in the understanding and treatment of these brain diseases. ..
  26. STRUCTURE & FUNCTION OF CALMODULIN-DEPENDENT KINASE II
    M Waxham; Fiscal Year: 1992
    ..Synapses are the sites of cell-cell communication in brain and have been the focus of studies on neuronal plasticity associated with learning and memory, synaptic remodeling following lesion and CNS development...
  27. Activity-dependent microRNA expression and function in the mature nervous system
    KARL H contact OBRIETAN; Fiscal Year: 2010
    ..microRNA expression patterns in the mature nervous system and, importantly, whether microRNA regulate neuronal plasticity and cell viability...
  28. Glutamate Transmission and Behavioral Sensitization
    MARINA WOLF; Fiscal Year: 2007
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  29. Glutamate Transmission and Behavioral Sensitization
    MARINA ELIZABETH WOLF; Fiscal Year: 2010
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  30. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2007
    ..are to gain novel insights into the pathophysiology of extended allodynia during migraine by studying neuronal plasticity of nociceptive thalamic neurons that process sensory information from the dura and from cephalic and ..
  31. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY, & AGING
    Carol Barnes; Fiscal Year: 1993
    ..Understanding such changes in neuronal plasticity may have an impact on therapeutic strategies for memory disorders in both normal and pathological ..
  32. NARP AND GLUTAMATE RECEPTOR CLUSTERING
    Paul F Worley; Fiscal Year: 2010
    ..is transcriptionally up-regulated in brain neurons in response to patterns of synaptic activity that evoke neuronal plasticity. Our broad goal is to understand how pentraxins contribute to neural plasticity, and thereby reveal new ..
  33. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN L KARTJE MD; Fiscal Year: 2010
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...