neuronal plasticity

Summary

Summary: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.

Top Publications

  1. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
  2. pmc The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
  3. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
  4. ncbi Theta burst stimulation of the human motor cortex
    Ying Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
  5. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
  6. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
  7. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
  8. pmc Arc-dependent synapse-specific homeostatic plasticity
    Jean Claude Beique
    The Solomon Snyder Department of Neuroscience, Johns Hopkins University, USA
    Proc Natl Acad Sci U S A 108:816-21. 2011
  9. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
  10. doi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009

Detail Information

Publications300 found, 100 shown here

  1. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..Therefore, the local cortical network structure can be viewed as a skeleton of stronger connections in a sea of weaker ones. Such a skeleton is likely to play an important role in network dynamics and should be investigated further...
  2. pmc The self-tuning neuron: synaptic scaling of excitatory synapses
    Gina G Turrigiano
    Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Cell 135:422-35. 2008
    ..Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales...
  3. ncbi Emotion circuits in the brain
    J E Ledoux
    Center for Neural Science, New York University, New York 10003, USA
    Annu Rev Neurosci 23:155-84. 2000
    ..With so much research being done in this area today, it is important that the mistakes of the past not be made again. It is also time to expand from this foundation into broader aspects of mind and behavior...
  4. ncbi Theta burst stimulation of the human motor cortex
    Ying Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
    ....
  5. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  6. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
    ....
  7. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments...
  8. pmc Arc-dependent synapse-specific homeostatic plasticity
    Jean Claude Beique
    The Solomon Snyder Department of Neuroscience, Johns Hopkins University, USA
    Proc Natl Acad Sci U S A 108:816-21. 2011
    ..Together, our results document an extra level of regulation of synaptic function that bears important computational consequences on information storage in the brain...
  9. ncbi Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  10. doi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
    ..This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions...
  11. pmc Correction of fragile X syndrome in mice
    Gul Dolen
    Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 56:955-62. 2007
    ..Our results demonstrate that mGluR5 contributes significantly to the pathogenesis of the disease, a finding that has significant therapeutic implications for fragile X and related developmental disorders...
  12. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  13. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  14. doi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat...
  15. ncbi Local sleep and learning
    Reto Huber
    Department of Psychiatry, University of Wisconsin, Madison, Wisconsin 53719, USA
    Nature 430:78-81. 2004
    ..Furthermore, we show that the local increase in SWA after learning correlates with improved performance of the task after sleep. Thus, sleep homeostasis can be induced on a local level and can benefit performance...
  16. ncbi The organization of recent and remote memories
    Paul W Frankland
    Program in Integrative Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1XB
    Nat Rev Neurosci 6:119-30. 2005
    ..However, recent studies have begun to shed light on how remote memories are organized in the cortex, and the molecular and cellular events that underlie their consolidation...
  17. ncbi Long-term depression in the CNS
    Graham L Collingridge
    Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Nat Rev Neurosci 11:459-73. 2010
    ..In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases...
  18. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  19. ncbi Short-term synaptic plasticity
    Robert S Zucker
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 64:355-405. 2002
    ..Finally, we summarize the recent literature on putative molecular players in synaptic plasticity and the effects of genetic manipulations and other modulatory influences...
  20. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  21. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    ....
  22. doi The mystery and magic of glia: a perspective on their roles in health and disease
    Ben A Barres
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neuron 60:430-40. 2008
    ..I argue that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly...
  23. ncbi Synaptic plasticity: multiple forms, functions, and mechanisms
    Ami Citri
    Department of Psychiatry and Behavioral Sciences, Nancy Pritzker Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304 5485, USA
    Neuropsychopharmacology 33:18-41. 2008
    ..We also provide examples of the possible developmental and behavioral functions of synaptic plasticity and how maladaptive synaptic plasticity may contribute to neuropsychiatric disorders...
  24. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
  25. pmc Unraveling mechanisms of homeostatic synaptic plasticity
    Karine Pozo
    MRC Cell Biology Unit and MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuron 66:337-51. 2010
    ..Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity...
  26. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    ..Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress...
  27. ncbi Dendritic protein synthesis, synaptic plasticity, and memory
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Cell 127:49-58. 2006
    ..Here, we review the experimental support for this idea and highlight some of the key questions outstanding in this area...
  28. doi New views of Arc, a master regulator of synaptic plasticity
    Jason D Shepherd
    Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 14:279-84. 2011
    ....
  29. pmc Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo
    Aaron S Nudelman
    Department of Pharmacology, University of Washington, Seattle, Washington
    Hippocampus 20:492-8. 2010
    ..We conclude that miR-132 is an activity-dependent microRNA in vivo, and may contribute to the long-lasting proteomic changes required for experience-dependent neuronal plasticity.
  30. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species...
  31. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  32. ncbi Synaptic plasticity and dysconnection in schizophrenia
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Biol Psychiatry 59:929-39. 2006
    ..Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia...
  33. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..its transcriptional and translational regulation, the functions of the Arc protein in multiple forms of neuronal plasticity [long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity], and its broader ..
  34. ncbi The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    Zheng Li
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:873-87. 2004
    ..Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites...
  35. pmc Actin in dendritic spines: connecting dynamics to function
    Pirta Hotulainen
    Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland
    J Cell Biol 189:619-29. 2010
    ..Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory...
  36. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..The mature ECM is thus inhibitory for experience-dependent plasticity, and degradation of CSPGs reactivates cortical plasticity...
  37. pmc Functional specialization for auditory-spatial processing in the occipital cortex of congenitally blind humans
    Olivier Collignon
    Centre de Recherche en Neuropsychologie et Cognition, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 108:4435-40. 2011
    ....
  38. doi The synapsins: key actors of synapse function and plasticity
    F Cesca
    Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy
    Prog Neurobiol 91:313-48. 2010
    ..and functioning of neuronal networks, these proteins are extremely important in the fine-tuning of neuronal plasticity, as shown by the epileptic phenotype and behavioural abnormalities characterising mouse lines lacking one ..
  39. ncbi Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
  40. ncbi Neurotrophins as synaptic modulators
    M M Poo
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Neurosci 2:24-32. 2001
    ..By this account, neurotrophins may participate in activity-dependent synaptic plasticity, linking synaptic activity with long-term functional and structural modification of synaptic connections...
  41. ncbi Polychronization: computation with spikes
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Neural Comput 18:245-82. 2006
    ....
  42. pmc Experience-dependent structural plasticity in the cortex
    Min Fu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    Trends Neurosci 34:177-87. 2011
    ..Therefore, circuit plasticity, mediated by structural remodeling, provides an underlying mechanism for learning and memory...
  43. pmc Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  44. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  45. pmc Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    Daniela Puzzo
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    J Neurosci 28:14537-45. 2008
    ....
  46. pmc Sleep and synaptic homeostasis: structural evidence in Drosophila
    Daniel Bushey
    Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA
    Science 332:1576-81. 2011
    The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary ..
  47. pmc Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
    Moustapha Cisse
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    Nature 469:47-52. 2011
    ..Thus, depletion of EphB2 is critical in amyloid-β-induced neuronal dysfunction. Increasing EphB2 levels or function could be beneficial in Alzheimer's disease...
  48. pmc Local GABA circuit control of experience-dependent plasticity in developing visual cortex
    T K Hensch
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 282:1504-8. 1998
    ..Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development...
  49. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  50. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..These data show that new hippocampal neurons can be preferentially recruited over mature granule cells in vitro and may provide a framework for how this small cell population can influence behavior...
  51. ncbi Synaptic computation
    L F Abbott
    Volen Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nature 431:796-803. 2004
    ..By expressing several forms of synaptic plasticity, a single neuron can convey an array of different signals to the neural circuit in which it operates...
  52. pmc Transcription factors in long-term memory and synaptic plasticity
    Cristina M Alberini
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Physiol Rev 89:121-45. 2009
    ..The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation...
  53. pmc Rapid formation and selective stabilization of synapses for enduring motor memories
    Tonghui Xu
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nature 462:915-9. 2009
    ..Our findings reveal that rapid, but long-lasting, synaptic reorganization is closely associated with motor learning. The data also suggest that stabilized neuronal connections are the foundation of durable motor memory...
  54. ncbi Exercise: a behavioral intervention to enhance brain health and plasticity
    Carl W Cotman
    Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    Trends Neurosci 25:295-301. 2002
    ..Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity...
  55. ncbi Recovery of learning and memory is associated with chromatin remodelling
    Andre Fischer
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 447:178-82. 2007
    ....
  56. pmc Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity
    Jason Aoto
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Neuron 60:308-20. 2008
    ..Together, our data suggest that RA functions in homeostatic plasticity as a signaling molecule that increases synaptic strength by a protein synthesis-dependent mechanism...
  57. ncbi LTP and LTD: an embarrassment of riches
    Robert C Malenka
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Neuron 44:5-21. 2004
    ..Here we review those forms of LTP and LTD for which mechanisms have been most firmly established. Examples are provided that show how these mechanisms can contribute to experience-dependent modifications of brain function...
  58. pmc BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    Yuan Lu
    Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neurobiol Learn Mem 89:312-23. 2008
    ..Finally, specific roles of BDNF in the acquisition, retention or extinction of LTM remain to be established...
  59. ncbi MAPK cascade signalling and synaptic plasticity
    Gareth M Thomas
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB 904, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Rev Neurosci 5:173-83. 2004
  60. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  61. ncbi Neuronal signalling of fear memory
    Stephen Maren
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 5:844-52. 2004
    ..Understanding the signalling of aversive memory by amygdala neurons opens new avenues for research into the neural systems that support fear behaviour...
  62. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ....
  63. ncbi Motor learning: its relevance to stroke recovery and neurorehabilitation
    John W Krakauer
    Stroke and Critical Care Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York NY, USA
    Curr Opin Neurol 19:84-90. 2006
    ..questions: (i) What is motor learning? (ii) Do patients with hemiparesis have a learning deficit? (iii) Is recovery after injury a form of motor learning? (iv) Are approaches based on motor learning principles useful for rehabilitation?..
  64. ncbi The amygdala and persistent pain
    Volker Neugebauer
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, 77555 1069, USA
    Neuroscientist 10:221-34. 2004
    ..It is conceivable, however, that amygdala plasticity plays an important role in emotional pain behavior and its modulation by affective state...
  65. ncbi Stress and hippocampal plasticity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Annu Rev Neurosci 22:105-22. 1999
    ..It is important, from a therapeutic standpoint, to distinguish between a permanent loss of cells and a reversible atrophy...
  66. pmc Sleep and synaptic renormalization: a computational study
    Umberto Olcese
    Perceptual Robots Laboratory, Scuola Superiore Sant Anna, Pisa, Italy
    J Neurophysiol 104:3476-93. 2010
    ....
  67. doi Multiple roles of calcium ions in the regulation of neurotransmitter release
    Erwin Neher
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Neuron 59:861-72. 2008
    ..Such coupling is essential for rendering vesicles sensitive to short [Ca(2+)] transients, generated during action potentials...
  68. ncbi Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
    Daniela Carulli
    Cambridge University Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge, CB2 0PY, UK
    Brain 133:2331-47. 2010
    ..The organization of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the control of central nervous system plasticity by the extracellular matrix...
  69. pmc Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    Hsiao Tuan Chao
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 468:263-9. 2010
    ..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
  70. ncbi Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    Gerd Kempermann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Ann Neurol 52:135-43. 2002
    ..Activity exerts not only an acute but also a sustained effect on brain plasticity...
  71. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  72. doi Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
    Lorenzo A Cingolani
    MRC Laboratory for Molecular Cell Biology and MRC Cell Biology Unit, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Rev Neurosci 9:344-56. 2008
    ..The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function...
  73. doi Stably maintained dendritic spines are associated with lifelong memories
    Guang Yang
    Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    Nature 462:920-4. 2009
    ..These studies indicate that learning and daily sensory experience leave minute but permanent marks on cortical connections and suggest that lifelong memories are stored in largely stably connected synaptic networks...
  74. pmc Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis
    Cagla Eroglu
    Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
    Cell 139:380-92. 2009
    ..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
  75. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ....
  76. pmc A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS
    Binith Cheeran
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Physiol 586:5717-25. 2008
    ..Thus the polymorphism may be one factor that influences the natural response of the brain to injury and disease...
  77. ncbi A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex
    Alexander Wolters
    Human Cortical Physiology Laboratory, Department of Neurology, University of Rostock, Germany
    J Neurophysiol 89:2339-45. 2003
    ..Together with earlier findings, this study suggests that strict temporal Hebbian rules govern the induction of long-term potentiation/long-term depression-like phenomena in vivo in the human primary motor cortex...
  78. pmc Local, persistent activation of Rho GTPases during plasticity of single dendritic spines
    Hideji Murakoshi
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Nature 472:100-4. 2011
    ..RhoA and Cdc42 activation depended on Ca(2+)/calmodulin-dependent kinase (CaMKII). Thus, RhoA and Cdc42 relay transient CaMKII activation to synapse-specific, long-term signalling required for spine structural plasticity...
  79. ncbi Adaptive exponential integrate-and-fire model as an effective description of neuronal activity
    Romain Brette
    Dept d Informatique, Equipe Odyssée, Ecole Normale Superieure, 45 rue d Ulm, 75230 Paris Cedex 05, France
    J Neurophysiol 94:3637-42. 2005
    ..These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro...
  80. doi Structural dynamics of dendritic spines in memory and cognition
    Haruo Kasai
    Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, and Center for NanoBio Integration, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Trends Neurosci 33:121-9. 2010
    ..Thus, spine dynamics are cellular phenomena with important implications for cognition and memory. Furthermore, impaired spine dynamics can cause psychiatric and neurodevelopmental disorders...
  81. ncbi Spike timing-dependent plasticity of neural circuits
    Yang Dan
    Division of Neurobiology, Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720 USA
    Neuron 44:23-30. 2004
    ..Finally, we discuss timing-dependent modification of neuronal receptive fields and human visual perception and the computational significance of STDP as a synaptic learning rule...
  82. ncbi Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
    Ken ichi Okamoto
    RIKEN MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:1104-12. 2004
    ..This bidirectional regulation of actin is actively involved in protein assembly and disassembly and provides a substrate for bidirectional synaptic plasticity...
  83. ncbi Enriched environments, experience-dependent plasticity and disorders of the nervous system
    Jess Nithianantharajah
    Howard Florey Institute, National Neuroscience Facility, University of Melbourne, Victoria 3010, Australia
    Nat Rev Neurosci 7:697-709. 2006
    ..Here, we review these findings on the environmental modulators of pathogenesis and gene-environment interactions in CNS disorders, and discuss their therapeutic implications...
  84. pmc Decoding the epigenetic language of neuronal plasticity
    Emiliana Borrelli
    Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
    Neuron 60:961-74. 2008
    ....
  85. pmc A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex
    Ming Gao
    Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 30:7168-78. 2010
    ..1 KOs. Our results demonstrate that Arc/Arg3.1 plays a selective role in regulating visual experience-dependent homeostatic plasticity of excitatory synaptic transmission in vivo...
  86. ncbi Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus
    J S Snyder
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 85:2423-31. 2001
    ..Since DG is the major source of the afferent inputs into the hippocampus, the production and the plasticity of new neurons may have an important role in the hippocampal functions such as learning and memory...
  87. ncbi Solving the distal reward problem through linkage of STDP and dopamine signaling
    Eugene M Izhikevich
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 17:2443-52. 2007
    ..This study emphasizes the importance of precise firing patterns in brain dynamics and suggests how a global diffusive reinforcement signal in the form of extracellular DA can selectively influence the right synapses at the right time...
  88. pmc Balancing structure and function at hippocampal dendritic spines
    Jennifer N Bourne
    Center for Learning and Memory, Department of Neurobiology, University of Texas, Austin, Texas 78712 0805, USA
    Annu Rev Neurosci 31:47-67. 2008
    ..Key to this endeavor is having sufficient resolution to determine the extrinsic factors (such as perisynaptic astroglia) and the intrinsic factors (such as core subcellular organelles) that are required to build and maintain synapses...
  89. doi Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
    Vladyslav V Vyazovskiy
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    Nat Neurosci 11:200-8. 2008
    ..Thus, wakefulness appears to be associated with net synaptic potentiation, whereas sleep may favor global synaptic depression, thereby preserving an overall balance of synaptic strength...
  90. pmc Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I
    Dale A Fortin
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 30:11565-75. 2010
    ..Together, our results suggest that synaptic recruitment of CP-AMPARs via CaMKI may provide a mechanistic link between NMDAR activation in LTP and regulation of a signaling pathway that drives spine enlargement via actin polymerization...
  91. pmc Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
    Zhong Wu Liu
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:8671-5. 2010
    ..Since stronger synapses require more energy, space, and supplies, a generalized renormalization of synapses may be an important function of sleep...
  92. pmc Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
    Takeo Saneyoshi
    Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Curr Opin Neurobiol 20:108-15. 2010
    ..Owing to space limitations, it will focus on mammalian excitatory (i.e. glutamatergic) synapses and will not consider several activity-independent signaling pathways (e.g. ephrinB receptor) that also modulate spine and synapse formation...
  93. ncbi Perineuronal nets protect fear memories from erasure
    Nadine Gogolla
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Science 325:1258-61. 2009
    ..This result indicates that intact PNNs mediate the formation of erasure-resistant fear memories and identifies a molecular mechanism closing a postnatal critical period during which traumatic memories can be erased by extinction...
  94. ncbi Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  95. ncbi The stressed hippocampus, synaptic plasticity and lost memories
    Jeansok J Kim
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520 8205, USA
    Nat Rev Neurosci 3:453-62. 2002
    ..Here, we provide an overview of the neurobiology of stress memory interactions, and present a neural endocrine model to explain how stress modifies hippocampal functioning...
  96. pmc Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
    ..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy.
  97. ncbi The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    J M Bessa
    Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Mol Psychiatry 14:764-73, 739. 2009
    ..Instead, our experiments suggest re-establishment of neuronal plasticity (dendritic remodeling and synaptic contacts) in the hippocampus and prefrontal cortex, rather than ..
  98. pmc Altered synaptic plasticity in a mouse model of fragile X mental retardation
    Kimberly M Huber
    Department of Neuroscience, Howard Hughes Medical Institute, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 99:7746-50. 2002
    ..This finding indicates that FMRP plays an important functional role in regulating activity-dependent synaptic plasticity in the brain and suggests new therapeutic approaches for fragile X syndrome...
  99. doi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  100. pmc Spatial learning depends on both the addition and removal of new hippocampal neurons
    David Dupret
    INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France
    PLoS Biol 5:e214. 2007
    ..In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons...
  101. pmc Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
    J Neurosci 27:6128-40. 2007
    ..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex...

Research Grants91

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..More importantly, neuronal plasticity during adolescence may still allow reversibility of disease-related brain effects through teaching coping ..
  2. Probing the Structure of the Synapse Using Superresolution Light Microscopy
    Gina Turrigiano; Fiscal Year: 2009
    ..abstract_text> ..
  3. HLA and schizophrenia: a high-throughput sequencing study
    DOUGLAS FREDERICK LEVINSON; Fiscal Year: 2012
    ..cases, and are related to auto-immune processes, infection, and/or the role of MHC Class I loci in neuronal plasticity. It is therefore critical to dissect the effects ofHLA variants on schizophrenia risk...
  4. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2010
    ..expand ongoing activities under the Parent Grant to define the mechanistic relationships between neuronal plasticity and spinal immune activation in chronic pain in the spine...
  5. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..Both NGF and acetylcholine are essential for maintaining neuronal plasticity. We hypothesize that the ethanol-induced memory loss results from losses in neuronal plasticity...
  6. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2004
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  7. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2005
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  8. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  9. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2003
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  10. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...
  11. ESTROGEN AND NEUROTRANSMITTER SYSTEMS IN HIPPOCAMPUS
    Nancy Weiland; Fiscal Year: 1993
    The neuronal plasticity associated with learning and memory and epileptiform activity depends on precise balances in the activity of two major neurotransmitter systems in the hippocampus: the excitatory glutamate/aspartate neurons and ..
  12. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ..More effective treatment for gait deficits in CP is needed at an early age when there is optimal neuronal plasticity, rapid musculoskeletal growth and a greater likelihood of preventing gait abnormalities...
  13. EFFECTS OF APOE ON OLFACTORY NEURON PLASTICITY IN MICE
    Britto Nathan; Fiscal Year: 2005
    ..One possible mechanism of apoE involvement in AD may be on the process involved with neuronal plasticity. Consistent with this proposed function, our in vitro studies have demonstrated that cortical neurons grown ..
  14. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2010
    ..the relative importance of mucosal or neuronal sources of 5-HT in enteric neuroprotection, neurogenesis, neuronal plasticity and inflammation...
  15. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael Gershon; Fiscal Year: 2009
    ..the relative importance of mucosal or neuronal sources of 5-HT in enteric neuroprotection, neurogenesis, neuronal plasticity and inflammation...
  16. DOPAMINE/GLUTAMATE INTERACTIONS IN NUCLEUS ACCUMBENS
    MARINA WOLF; Fiscal Year: 2000
    ..This is an important question, because glutamate systems are likely to mediate the neuronal plasticity underlying the transition from drug experimentation to drug dependency...
  17. DOPAMINE/GLUTAMATE INTERACTIONS IN NUCLEUS ACCUMBENS
    MARINA WOLF; Fiscal Year: 2001
    ..This is an important question, because glutamate systems are likely to mediate the neuronal plasticity underlying the transition from drug experimentation to drug dependency...
  18. CORTICOTROPIN RELEASING HORMONE SIGNALING AND NEWBORN NEURON CIRCUIT INTEGRATION
    Isabella Garcia; Fiscal Year: 2012
    ..in the mammalian brain represents an extraordinary example of continued cellular and structural neuronal plasticity. Although the phenomenology of this process has been well established, the molecular and genetic mechanisms ..
  19. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian-Smith; Fiscal Year: 2012
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  20. Astrocyte-endothelial crosstalk after cerebral ischemia and hemorrhage
    Eng H Lo; Fiscal Year: 2011
    ..crosstalk after cerebral ischemia and hemorrhage Reactive astrocytes were traditionally thought to inhibit neuronal plasticity after CNS injury. But emerging data now suggest that reactive astrocytes may also have beneficial actions...
  21. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  22. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2009
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  23. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2010
    ..Our current and proposed studies focus on examining factors that impede or promote the recovery of hand function, and our findings will enable the development of more effective treatments of cervical nerve and spinal injury ..
  24. Genomic Approaches to Neuronal Diversity and Plasticity
    Jingyue Ju; Fiscal Year: 2007
    ..pattern of interconnections, which underlie behavior and, (3) the molecular basis of synapse-specific neuronal plasticity and neuronal growth...
  25. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2007
    ..A better understanding of the post-lesion reorganization of the somatosensory pathways is needed if patients with avulsed spinal dorsal roots are to be treated more effectively. ..
  26. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2005
    ..A better understanding of the post-lesion reorganization of the somatosensory pathways is needed if patients with avulsed spinal dorsal roots are to be treated more effectively. ..
  27. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2004
    ..A better understanding of the post-lesion reorganization of the somatosensory pathways is needed if patients with avulsed spinal dorsal roots are to be treated more effectively. ..
  28. Hand Use and Neuronal Plasticity After Dorsal Rhizotomy
    Corinna Darian Smith; Fiscal Year: 2006
    ..A better understanding of the post-lesion reorganization of the somatosensory pathways is needed if patients with avulsed spinal dorsal roots are to be treated more effectively. ..
  29. Target regulation of neuronal plasticity
    Keith Crutcher; Fiscal Year: 2007
    ..Considerable progress has been made in identifying factors that play important roles in regulating neuronal plasticity, both during development and in maturity...
  30. Target regulation of neuronal plasticity
    David Pettigrew; Fiscal Year: 2009
    Considerable progress has been made in identifying factors that play important roles in regulating neuronal plasticity, both during development and in maturity. The PI has been actively studying one example of such plasticity, i.e...
  31. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MCCARSON; Fiscal Year: 2003
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  32. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MCCARSON; Fiscal Year: 2001
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  33. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2010
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  34. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MCCARSON; Fiscal Year: 2000
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  35. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MC CARSON; Fiscal Year: 2004
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  36. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2009
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  37. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2011
    ..Cluster analysis should provide insight as to whether there are interneuron cell types that are more structurally plastic than others, and whether subsets of interneurons exhibit structural plasticity correlated with OD plasticity. ..
  38. NOCICEPTIVE SENSORY REGULATION OF NEUROKININ RECEPTORS
    KENNETH MCCARSON; Fiscal Year: 2002
    ..application by a new investigator addresses the molecular consequences of chronic pain and how pain-induced neuronal plasticity alters sensory processing...
  39. Molecular Profiling of Song Nucleus HVC in the Zebra Finch
    CLAUDIO MELLO; Fiscal Year: 2009
    ..vocal learning and communication, the action of sex hormones on the brain and behavior, seasonal and adult neuronal plasticity, and the discovery of continued neuronal replacement in the vertebrate brain...
  40. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
    ..Regulation of neurotransmitter receptor efficacy and control of neuronal plasticity, as evidenced in receptor desensitization and chronic down-regulation mechanisms, are recognized as part of ..
  41. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2005
    ..Regulation of neurotransmitter receptor efficacy and control of neuronal plasticity, as evidenced in receptor desensitization and chronic down-regulation mechanisms, are recognized as part of ..
  42. TRANS-SYNAPTIC SIGNALING DURING NEUROMUSCULAR DEVELOPMENT
    Graeme W Davis; Fiscal Year: 2010
    ..nervous system, NF-kB signaling system has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. At the neuromuscular junction, activation of NF-kB has been implicated in the mechanisms of muscle wasting ..
  43. Neuronal plasticity and cerebellar circuitry
    NEAL BARMACK; Fiscal Year: 2009
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  44. Neuronal plasticity and cerebellar circuitry
    NEAL BARMACK; Fiscal Year: 2007
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  45. Neuronal plasticity and cerebellar circuitry
    Neal H Barmack; Fiscal Year: 2010
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  46. Neuronal plasticity and cerebellar circuitry
    NEAL BARMACK; Fiscal Year: 2009
    ..The proposed research will speed application of molecular techniques to the treatment of patients with cerebellar disorders. ..
  47. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2010
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  48. ACC Sensitization in Visceral Hypersensitive Rats
    Ying Li; Fiscal Year: 2006
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  49. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2009
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  50. ACC Sensitization in Visceral Hypersensitive Rats
    Ying Li; Fiscal Year: 2007
    ..that persistence of a heightened tonic visceral afferent nociceptive input to the ACC induces ACC neuronal plasticity characterized by an increase in synaptic transmission...
  51. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA LYNN GILLANI; Fiscal Year: 2010
    ..pyramidal cells, and layer V pyramidal cells) of Golgi-Cox processed brains will be examined for structural neuronal plasticity by quantification of dendritic arborization, spine density, and spine morphology...
  52. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA GILLANI; Fiscal Year: 2007
    ..pyramidal cells, and layer V pyramidal cells) of Golgi-Cox processed brains will be examined for structural neuronal plasticity by quantification of dendritic arborization, spine density, and spine morphology...
  53. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA GILLANI; Fiscal Year: 2009
    ..pyramidal cells, and layer V pyramidal cells) of Golgi-Cox processed brains will be examined for structural neuronal plasticity by quantification of dendritic arborization, spine density, and spine morphology...
  54. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY & AGING
    Carol Barnes; Fiscal Year: 1999
    ..The strength of this interaction is the ability to combine and apply the most powerful available methods to test the hypotheses under study, which could not be accomplished in either laboratory in isolation. ..
  55. Gonadotropin involvement in cognition and Alzheimer's disease: Therapeutic Implic
    Gemma Casadesus; Fiscal Year: 2009
    Estrogen is thought to play an important role in age-related cognitive decline, neuronal plasticity, as well as the pathogenesis of Alzheimer disease (AD)...
  56. Gonadotropin involvement in cognition and Alzheimer's disease: Therapeutic Implic
    Gemma Casadesus; Fiscal Year: 2010
    Estrogen is thought to play an important role in age-related cognitive decline, neuronal plasticity, as well as the pathogenesis of Alzheimer disease (AD)...
  57. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  58. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2004
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  59. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2002
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  60. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2003
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  61. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2001
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  62. NEURONAL PLASTICITY IN THE RETINA
    Stuart C Mangel; Fiscal Year: 2010
    ..Thus, increased knowledge of the actions of dopamine and adenosine in the retina may aid in the understanding and treatment of these brain diseases. ..
  63. NEURONAL PLASTICITY IN ALS SPINAL CORD NEURONS
    Joe Springer; Fiscal Year: 1991
    ..The experiments proposed in this application will provide a better understanding of the cellular and molecular events associated with denervation-reinnervation in ALS spinal cord, and of neuronal plasticity in the CNS.
  64. A Quantitative Proteomics Platform to Characterize the Nicotine-Dependent Brain
    Benjamin Cravatt; Fiscal Year: 2009
    ..b>Neuronal plasticity is furthermore known to rely heavily on post-translational events that regulate protein structure and ..
  65. STRUCTURE & FUNCTION OF CALMODULIN-DEPENDENT KINASE II
    M Waxham; Fiscal Year: 1990
    ..Synapses are the sites of cell-cell communication in brain and have been the focus of studies on neuronal plasticity associated with learning and memory, synaptic remodeling following lesion and CNS development...
  66. STRUCTURE & FUNCTION OF CALMODULIN-DEPENDENT KINASE II
    M Waxham; Fiscal Year: 1992
    ..Synapses are the sites of cell-cell communication in brain and have been the focus of studies on neuronal plasticity associated with learning and memory, synaptic remodeling following lesion and CNS development...
  67. STRUCTURE & FUNCTION OF CALMODULIN-DEPENDENT KINASE II
    M Waxham; Fiscal Year: 1991
    ..Synapses are the sites of cell-cell communication in brain and have been the focus of studies on neuronal plasticity associated with learning and memory, synaptic remodeling following lesion and CNS development...
  68. TRANS-SYNAPTIC SIGNALING DURING NEUROMUSCULAR DEVELOPMENT
    Graeme Davis; Fiscal Year: 2009
    ..nervous system, NF-kB signaling system has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. At the neuromuscular junction, activation of NF-kB has been implicated in the mechanisms of muscle wasting ..
  69. NMDA RECEPTOR IN LEAD INDUCED COGNITIVE DEFICIT
    EDSON ALBUQUERQUE; Fiscal Year: 1999
    ..NMDA receptors and alpha7-bearing nAChR are involved in memory and learning as well as in other forms of neuronal plasticity and development, it is very likely that inhibition of these receptors by Pb2+, particularly during early ..
  70. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2007
    ..the mammalian spinal cord following a complete spinal cord transection (ST) suggests a remarkable level of neuronal plasticity in the absence of supraspinal input...
  71. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2003
    ..the mammalian spinal cord following a complete spinal cord transection (ST) suggests a remarkable level of neuronal plasticity in the absence of supraspinal input...
  72. SPINAL PLASTICITY OF A CORRECTIVE KINEMATIC RESPONSE
    V Edgerton; Fiscal Year: 2005
    ..the mammalian spinal cord following a complete spinal cord transection (ST) suggests a remarkable level of neuronal plasticity in the absence of supraspinal input...
  73. Immunotherapy to Improve Functional Outcomes after Chronic Stoke in the Aged
    GWENDOLYN LOUISE KARTJE; Fiscal Year: 2012
    ..We now plan to study the ability of anti-Nogo-A immunotherapy to enhance functional recovery and neuronal plasticity in the chronic stroke impaired rat...
  74. PKC-dependent GluR2 internalization in the spinal cord by persistent pain
    Yuan Xiang Tao; Fiscal Year: 2009
    ..GRIP and PICK1, may function in the synaptic AMPA receptor trafficking that is critical for many forms of neuronal plasticity. GRIP anchors GluR2 at synapses, whereas PICK1 brings PKC1 to synaptic GluR2...
  75. Activity-dependent microRNA expression and function in the mature nervous system
    KARL H contact OBRIETAN; Fiscal Year: 2010
    ..microRNA expression patterns in the mature nervous system and, importantly, whether microRNA regulate neuronal plasticity and cell viability...
  76. Glutamate Transmission and Behavioral Sensitization
    MARINA WOLF; Fiscal Year: 2009
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  77. Glutamate Transmission and Behavioral Sensitization
    MARINA WOLF; Fiscal Year: 2006
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  78. Glutamate Transmission and Behavioral Sensitization
    MARINA WOLF; Fiscal Year: 2007
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  79. Glutamate Transmission and Behavioral Sensitization
    MARINA ELIZABETH WOLF; Fiscal Year: 2010
    ..Addiction is believed to involve maladaptive neuronal plasticity that rewires motivational circuits, focusing behaviors on drug-seeking...
  80. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2005
    ..are to gain novel insights into the pathophysiology of extended allodynia during migraine by studying neuronal plasticity of nociceptive thalamic neurons that process sensory information from the dura and from cephalic and ..
  81. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2007
    ..are to gain novel insights into the pathophysiology of extended allodynia during migraine by studying neuronal plasticity of nociceptive thalamic neurons that process sensory information from the dura and from cephalic and ..
  82. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY, & AGING
    Carol Barnes; Fiscal Year: 1993
    ..Understanding such changes in neuronal plasticity may have an impact on therapeutic strategies for memory disorders in both normal and pathological ..
  83. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2011
    Inducible gene expression plays a central role in neuronal plasticity, learning, and memory. Dysregulation of these processes can lead to severe neuronal disorders and cognitive impairment...
  84. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY, & AGING
    Carol Barnes; Fiscal Year: 1991
    ..Understanding such changes in neuronal plasticity may have an impact on therapeutic strategies for memory disorders in both normal and pathological ..
  85. TRANSCRIPTION FACTOR GENES, NEURONAL PLASTICITY, & AGING
    Carol Barnes; Fiscal Year: 1992
    ..Understanding such changes in neuronal plasticity may have an impact on therapeutic strategies for memory disorders in both normal and pathological ..
  86. NARP AND GLUTAMATE RECEPTOR CLUSTERING
    Paul F Worley; Fiscal Year: 2010
    ..is transcriptionally up-regulated in brain neurons in response to patterns of synaptic activity that evoke neuronal plasticity. Our broad goal is to understand how pentraxins contribute to neural plasticity, and thereby reveal new ..
  87. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN L KARTJE MD; Fiscal Year: 2010
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...
  88. Neuronal Plasticity and Recovery of Function After Stroke
    GWENDOLYN KARTJE MD; Fiscal Year: 2009
    ..We have shown that anti-Nogo-A immunotherapy results in neuronal plasticity and functional recovery after ischemic stroke in adult rats...
  89. A Quantitative Proteomics Platform to Characterize the Nicotine-Dependent Brain
    JOHN ROBERT YATES; Fiscal Year: 2010
    ..b>Neuronal plasticity is furthermore known to rely heavily on post-translational events that regulate protein structure and ..
  90. STRUCTURAL CORRELATES OF CORTICAL INFORMATION PROCESSING
    Sharon Juliano; Fiscal Year: 1991
    ..Mechanisms suggested to mediate such neuronal plasticity include the observations that (i) receptors selective to a specific excitatory amino acid (N-methyl-D-..