neural inhibition

Summary

Top Publications

  1. ncbi GABA A,slow: causes and consequences
    Marco Capogna
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Trends Neurosci 34:101-12. 2011
  2. ncbi Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
    Michael Okun
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Neurosci 11:535-7. 2008
  3. pmc Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
    Janos Szabadics
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:14831-6. 2007
  4. pmc Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    Toshiharu Yasaka
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 581:603-18. 2007
  5. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
  6. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
  7. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
  8. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
  9. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
  10. ncbi Model of autism: increased ratio of excitation/inhibition in key neural systems
    J L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
    Genes Brain Behav 2:255-67. 2003

Detail Information

Publications291 found, 100 shown here

  1. ncbi GABA A,slow: causes and consequences
    Marco Capogna
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Trends Neurosci 34:101-12. 2011
    ....
  2. ncbi Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
    Michael Okun
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Neurosci 11:535-7. 2008
    ....
  3. pmc Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
    Janos Szabadics
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:14831-6. 2007
    ..These results reveal a form of GABA(A) receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition...
  4. pmc Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    Toshiharu Yasaka
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 581:603-18. 2007
    ..These results make it possible to identify primary afferent circuits associated with particular types of SG neurone...
  5. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    ....
  6. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
    ..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
  7. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  8. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
    ....
  9. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
  10. ncbi Model of autism: increased ratio of excitation/inhibition in key neural systems
    J L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
    Genes Brain Behav 2:255-67. 2003
    ..Furthermore, the model suggests potential therapeutic interventions...
  11. pmc Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
    Inseon Song
    RIKEN Brain Science Institute BSI, Wako, Saitama 351 0198, Japan
    Nat Commun 2:376. 2011
    ..The described phenomenon suggests that the excitatory or inhibitory actions of the current are set not only by the reversal potential, but also by the conductance...
  12. pmc How inhibition shapes cortical activity
    Jeffry S Isaacson
    Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093 0634, USA
    Neuron 72:231-43. 2011
    ..We discuss current views of how inhibition regulates the function of cortical neurons and point to a number of important open questions...
  13. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  14. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
  15. ncbi Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition
    Bilal Haider
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:4535-45. 2006
    ....
  16. ncbi Neuroligin 2 is exclusively localized to inhibitory synapses
    Frederique Varoqueaux
    Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
    Eur J Cell Biol 83:449-56. 2004
    ..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization...
  17. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  18. ncbi A disinhibitory microcircuit for associative fear learning in the auditory cortex
    Johannes J Letzkus
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 480:331-5. 2011
    ....
  19. ncbi Tonically active GABA A receptors: modulating gain and maintaining the tone
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Trends Neurosci 27:262-9. 2004
    ....
  20. pmc Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  21. ncbi Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
    Marlene Bartos
    Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Rev Neurosci 8:45-56. 2007
    ..Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators...
  22. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  23. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  24. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ....
  25. pmc Extrasynaptic GABAA receptors: form, pharmacology, and function
    Delia Belelli
    Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Neurosci 29:12757-63. 2009
    ..In addition, it emphasizes the important role of extrasynaptic GABA(A) receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes...
  26. pmc Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome
    Jose Luis Olmos-Serrano
    Center for Neuroscience Research, Children s National Medical Center, Washington DC, 20010, USA
    J Neurosci 30:9929-38. 2010
    ....
  27. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
    ..Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability...
  28. ncbi Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety
    Jamie L Maguire
    Department of Neurology, The David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, California 90095, USA
    Nat Neurosci 8:797-804. 2005
    ..Our findings are consistent with possible deficiencies in regulatory mechanisms controlling normal cycling of deltaGABA(A)Rs in individuals with catamenial epilepsy or PMDD...
  29. pmc Modulating parameters of excitability during and after transcranial direct current stimulation of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    J Physiol 568:291-303. 2005
    ..In contrast, the after-effects of tDCS are due to shifts in intracortical inhibition and facilitation, and at least partly also to facilitatory I-wave interaction, which is controlled by synaptic activity...
  30. ncbi GABAA receptor-mediated tonic inhibition in thalamic neurons
    David W Cope
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 25:11553-63. 2005
    ..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
  31. pmc Developmental sensory experience balances cortical excitation and inhibition
    Anja L Dorrn
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, and NeuroCure Neuroscience Research Center NWFZ, Berlin 13125, Germany
    Nature 465:932-6. 2010
    ..Thus, the pace of cortical synaptic receptive field development is set by progressive, experience-dependent refinement of intracortical inhibition...
  32. pmc Highly selective receptive fields in mouse visual cortex
    Cristopher M Niell
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:7520-36. 2008
    ..This quantitative description of receptive field properties should facilitate the use of mouse visual cortex as a system to address longstanding questions of visual neuroscience and cortical processing...
  33. ncbi Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    S G Brickley
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Nature 409:88-92. 2001
    ....
  34. ncbi Shunting inhibition modulates neuronal gain during synaptic excitation
    Simon J Mitchell
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 38:433-45. 2003
    ..Our results suggest that shunting inhibition can multiplicatively scale rate-coded information in neurons with high-variability synaptic inputs...
  35. ncbi Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
    ..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
  36. ncbi Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex
    Martine Hamann
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 33:625-33. 2002
    ..Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum...
  37. ncbi Synaptic connections and small circuits involving excitatory and inhibitory neurons in layers 2-5 of adult rat and cat neocortex: triple intracellular recordings and biocytin labelling in vitro
    Alex M Thomson
    Department of Physiology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Cereb Cortex 12:936-53. 2002
    ....
  38. ncbi Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?
    Joseph Glykys
    Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    J Neurosci 28:1421-6. 2008
    ..In conclusion, depending on the cell type, the alpha5 and delta subunits are the principal GABA(A)R subunits responsible for mediating the lion's share of tonic inhibition in hippocampal neurons...
  39. ncbi Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus
    Weizheng Wei
    Department of Neurology and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 23:10650-61. 2003
    ..Our results demonstrate a perisynaptic localization of delta subunit-containing GABA(A) receptors and indicate that these receptors can be activated by GABA overspill in the molecular layer...
  40. ncbi Control of excitatory and inhibitory synapse formation by neuroligins
    Ben Chih
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 307:1324-8. 2005
    ..Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons...
  41. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
  42. ncbi Functional dissociation in right inferior frontal cortex during performance of go/no-go task
    Junichi Chikazoe
    Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
    Cereb Cortex 19:146-52. 2009
    ..These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm...
  43. pmc Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
    Han Xu
    Department of Physiology and Neuroscience, Smilow Neuroscience Program, NYU School of Medicine, New York, NY 10016, USA
    Neuron 77:155-67. 2013
    ....
  44. pmc Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations
    Cindy Poo
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 62:850-61. 2009
    ..Together, our results reveal that global inhibition and oscillations are major synaptic mechanisms shaping odor representations in olfactory cortex...
  45. pmc Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning
    Guangying K Wu
    Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
    Neuron 52:705-15. 2006
    ..Thus, cortical intensity tuning is primarily determined by excitatory inputs and shaped by cortical inhibition through a dynamic control of excitatory and inhibitory timing...
  46. ncbi Encoding of conditioned fear in central amygdala inhibitory circuits
    Stephane Ciocchi
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 468:277-82. 2010
    ..Our results define the functional architecture of CEA microcircuits and their role in the acquisition and regulation of conditioned fear behaviour...
  47. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
    ..These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell...
  48. ncbi Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
    Andrea Hasenstaub
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 47:423-35. 2005
    ..Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex...
  49. ncbi Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  50. ncbi Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
    D Bai
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 59:814-24. 2001
    ..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
  51. ncbi Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
    ..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
  52. ncbi Effects of transcranial direct current stimulation over the human motor cortex on corticospinal and transcallosal excitability
    N Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 156:439-43. 2004
    ....
  53. ncbi GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex
    Luca Bragina
    Dipartimento di Neuroscienze, Universita Politecnica delle Marche, Ancona, Italy
    J Neurochem 105:1781-93. 2008
    ....
  54. pmc Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli
    Frédéric Brischoux
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Proc Natl Acad Sci U S A 106:4894-9. 2009
    ..Taken together, our results indicate that there are 2 functionally and anatomically distinct VTA dopamine systems...
  55. ncbi Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice
    Luc J Gentet
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Neuron 65:422-35. 2010
    ..In contrast, inhibitory neurons fire correlated action potentials at much higher frequencies driven by slower, smaller, and broadly synchronized depolarization...
  56. pmc Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
    Tim P Vogels
    Center for Neurobiology and Behavior, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 12:483-91. 2009
    ..Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals...
  57. ncbi GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 25:1-27. 2001
    ....
  58. ncbi Oscillations and sparsening of odor representations in the mushroom body
    Javier Perez-Orive
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 297:359-65. 2002
    ..These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks...
  59. ncbi Inhibition, spike threshold, and stimulus selectivity in primary visual cortex
    Nicholas J Priebe
    Section of Neurobiology, University of Texas at Austin, 1 University Station C0920, Austin, TX 78712, USA
    Neuron 57:482-97. 2008
    ..e., spike threshold, contrast saturation, and spike-rate rectification) can account for properties that have previously appeared to require lateral inhibition...
  60. pmc Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  61. pmc Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex
    Caroline A Runyan
    Department of Brain and Cognitive Sciences and Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 67:847-57. 2010
    ..These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties...
  62. pmc Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex
    Aaron M Kerlin
    Department of Neurobiology, Harvard Medical School, Goldenson 243, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:858-71. 2010
    ..These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population--a principle that may generalize across species and sensory modalities...
  63. ncbi Synaptic mechanisms of forward suppression in rat auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 47:437-45. 2005
    ....
  64. ncbi Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses
    Valerie Kilman
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:1328-37. 2002
    ..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity...
  65. ncbi Perisomatic inhibition
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Neuron 56:33-42. 2007
    ..The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex...
  66. pmc Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice
    Yunyong Ma
    Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506, USA
    J Neurosci 26:5069-82. 2006
    ..We conclude that much of the variability previously attributed to neocortical SOM+ interneurons can be accounted for by their natural grouping into distinct subtypes...
  67. ncbi Characterization of neocortical principal cells and interneurons by network interactions and extracellular features
    Peter Bartho
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave, Newark, NJ 07102, USA
    J Neurophysiol 92:600-8. 2004
    ..High-density parallel recordings of neuronal activity, determination of their physical location and their classification into pyramidal and interneuron classes provide the necessary tools for local circuit analysis...
  68. pmc GABAA receptor trafficking-mediated plasticity of inhibitory synapses
    Bernhard Luscher
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Neuron 70:385-409. 2011
    ..In addition, we review neuropeptide signaling pathways that affect neural excitability through changes in GABA(A)R trafficking...
  69. ncbi Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
    Annalisa Scimemi
    Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 25:10016-24. 2005
    ..The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures...
  70. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    ..Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs...
  71. pmc Inhibitory stabilization of the cortical network underlies visual surround suppression
    Hirofumi Ozeki
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 62:578-92. 2009
    ..We confirm two strong tests of this scenario experimentally and show through simulation that observed cell-to-cell variability in surround effects, from facilitation to suppression, can arise naturally from variability in the ISN...
  72. pmc A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo
    Yuanyuan Jiao
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Proc Natl Acad Sci U S A 108:12131-6. 2011
    ..These results suggest that postnatal experience, through activity-driven BDNF expression, controls cortical development by regulating FS cell-mediated perisomatic inhibition in vivo...
  73. ncbi Response facilitation and inhibition in subliminal priming
    Martin Eimer
    School of Psychology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biol Psychol 64:7-26. 2003
    ..Overall, results demonstrate that inhibitory mechanisms are involved in the control of response processes, even when motor activations are triggered by stimuli that are not accessible to conscious awareness...
  74. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
  75. ncbi Neural mechanisms of orientation selectivity in the visual cortex
    D Ferster
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Annu Rev Neurosci 23:441-71. 2000
    ..The modified feed-forward and the feedback models ascribe fundamentally different functions to cortical processing...
  76. ncbi Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area
    Christopher J Price
    Anatomical Neuropharmacology Unit, Medical Research Council, Oxford OX1 3TH, United Kingdom
    J Neurosci 25:6775-86. 2005
    ..Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus...
  77. ncbi Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
    Anastasia Shulga
    Institute of Biotechnology, Department of Biological and Environmental Sciences, and Neuroscience Center, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:6996-7005. 2008
    ..This is likely mediated through BDNF itself, because injured neurons reverse their response to this neurotrophin by switching the BDNF-induced downregulation of KCC2 to upregulation...
  78. ncbi Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasks
    K Rubia
    Institute of Psychiatry, King s College, London, UK
    Neuroimage 13:250-61. 2001
    ....
  79. ncbi Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003
    ..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...
  80. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
    ..Taken together, our data reveal important chemical distinctions between mouse inhibitory cortical neurons and indicate that PV, SOM, and VIP can differentially label a majority of mouse inhibitory cortical neurons...
  81. pmc Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice
    Bernhard Heinke
    Centre for Brain Research, Department of Neurophysiology, Medical University Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    J Physiol 560:249-66. 2004
    ..These results provide a base to elucidate the functional roles of this subgroup of GABAergic lamina II neurones, e.g. for nociception...
  82. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations...
  83. pmc Lateral sharpening of cortical frequency tuning by approximately balanced inhibition
    Guangying K Wu
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA
    Neuron 58:132-43. 2008
    ....
  84. ncbi Synchronization in networks of excitatory and inhibitory neurons with sparse, random connectivity
    Christoph Börgers
    Department of Mathematics, Tufts University, Medford, MA 02155, U S A
    Neural Comput 15:509-38. 2003
    ..Faster decay yields tighter synchrony. In particular, in models in which the inhibitory synapses are assumed to be instantaneous, the effects of sparse, random connectivity cannot be seen...
  85. pmc GABA A receptors: subtypes provide diversity of function and pharmacology
    Richard W Olsen
    Department of Molecular and Medical Pharmacology, Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1735, USA
    Neuropharmacology 56:141-8. 2009
    ..This list was first presented by Olsen & Sieghart (in press)...
  86. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    ..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
  87. ncbi Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Neurophysiol 114:600-4. 2003
    ..To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human...
  88. pmc Laminar specificity of functional input to distinct types of inhibitory cortical neurons
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:70-85. 2009
    ....
  89. pmc Activity-dependent gating of lateral inhibition in the mouse olfactory bulb
    ARMEN C AREVIAN
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nat Neurosci 11:80-7. 2008
    ..These results show that this previously unknown mechanism for specifying lateral inhibitory connections allows functional inhibitory connectivity to be dynamically remapped to relevant populations of neurons...
  90. ncbi Fast-spike interneurons and feedforward inhibition in awake sensory neocortex
    Harvey A Swadlow
    Department of Psychology, The University of Connecticut, Storrs, CT 06269, USA
    Cereb Cortex 13:25-32. 2003
    ..This fast, synchronous, highly sensitive and broadly tuned feed-forward inhibitory network is well suited to suppress spike generation in spiny neurons following all but the most optimal feedforward excitatory inputs...
  91. ncbi GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
    Sylvain Rheims
    INMED INSERM U901, Universite de la Mediterranee, Marseille, France
    J Neurochem 110:1330-8. 2009
    ..Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons...
  92. ncbi Topography and synaptic shaping of direction selectivity in primary auditory cortex
    Li I Zhang
    Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 424:201-5. 2003
    ..The spectral asymmetry of the synaptic TRFs co-varied with CF, as had direction selectivity and sideband asymmetry, and thus suggested a synaptic mechanism for the shaping of FM direction selectivity and its topographic ordering...
  93. ncbi Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability
    Mario Carta
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci 24:3746-51. 2004
    ..This effect is likely to have an impact on the flow of information through the cerebellar cortex and may contribute to the mechanism by which acute ingestion of alcoholic beverages induces motor impairment...
  94. ncbi Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain
    Ivan Pavlov
    UCL Institute of Neurology, University College London, London WC1 N3BG, United Kingdom
    J Neurosci 29:15341-50. 2009
    ....
  95. pmc GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:889-903. 2007
    ..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
  96. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory...
  97. ncbi Switching from automatic to controlled action by monkey medial frontal cortex
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Neurosci 10:240-8. 2007
    ..Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected...
  98. ncbi Development of GABA innervation in the cerebral and cerebellar cortices
    Z J Huang
    Cold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Neurosci 8:673-86. 2007
    ..The cellular and molecular mechanisms that specify and modify inhibitory innervation patterns are only just beginning to be understood...
  99. ncbi GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
    Stanislav Khirug
    Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:4635-9. 2008
    ..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters...
  100. ncbi Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
    Laetitia Gabernet
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Neuron 48:315-27. 2005
    ..Hence, feed-forward inhibitory circuits, classically known to sharpen spatial contrast of tactile inputs, also increase the temporal resolution in the somatosensory cortex...
  101. ncbi Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
    ..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...

Research Grants65

  1. Axonal Signaling in the Hippocampus
    Steven J Mennerick; Fiscal Year: 2010
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  2. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  3. In Vitro Mechanisms of Ethanol Induced Neuronal Death.
    Steven Mennerick; Fiscal Year: 2005
    ..The proposed experiments should lead to a better fundamental understanding of the mechanisms by which forebrain neurons are susceptible to ethanol-induced death. ..
  4. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  5. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  6. Spinal cord injury: Targeting local inhibition to improve outcome
    Linda J Noble; Fiscal Year: 2010
    ..The primary medications used to treat spasticity either enhance neural inhibition or inhibit muscle contraction...
  7. Assessing GABAergic Involvement in Schizophrenia-Like Cognitive Deficits in Rats
    Mark Renato Stefani; Fiscal Year: 2012
    ..by testing the hypothesis that schizophrenia-associated cognitive impairments are due to reduced neural inhibition, and identifying brain regions associated with cognitive functions using a rat model of the disorder, will ..
  8. Gene-based Neuromodulation: A New Paradigm for Functional Neurosurgery
    Nicholas M Boulis; Fiscal Year: 2012
    ..to motor neurons and transgene delivery to axons, can improve the potency and specificity of LC gene-based neural inhibition. 3) The Rheoswitch(r) inducible expression system will improve controlled LC delivery. 4) Neuronal Kir2...
  9. Safe Direct Current Neural Stimulation System
    GENE YEVGENY FRIDMAN; Fiscal Year: 2013
    ..as tinnitus, chronic pain, and epilepsy could be effectively treated by an implantable prosthesis capable of neural inhibition. One way to make DC safe involves directing DC flow of ions into the target tissue by switching mechanical ..
  10. Computational Neural and Behavioral Studies of Competition-Dependent Learning
    Kenneth A Norman; Fiscal Year: 2013
    ..learning could be implemented in the brain by leveraging oscillations in the strength of neural inhibition;they also demonstrated that competition- dependent learning could account for detailed patterns of human ..
  11. The roles of GABAergic and glycinergic inhibition in the adult MNTB
    Achim Klug; Fiscal Year: 2013
    ..The proposed studies focus on understanding a nucleus that is the most important source for neural inhibition to the auditory brain stem, and the results will thus be significant for developing treatments for medical ..
  12. NEURAL INHIBITION AND REM SLEEP DISORDERED BREATHING
    Joan Hendricks; Fiscal Year: 1992
    ..These studies should provide important information relating to the progression, pathophysiology and neurochemistry of SDB...
  13. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  14. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  15. Molecular Mechanisms of Subcellular Synapse Targeting
    Z Huang; Fiscal Year: 2008
    ..The establishment of a causal link between L1CAMs and construction of GABAergic circuits should provide a new perspective for understanding the molecular pathology of these mental illnesses and for treatment strategies. ..
  16. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  17. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 2007
    ..The roles of inhibition in this processing may be especially relevant for the decline of speech perception in the elderly, which is correlated with age related loss of GABAergic neurons in the auditory system. ..
  18. Influence of reward devaluation on striatal activity
    HOWARD CROMWELL; Fiscal Year: 2003
    ....
  19. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  20. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..
  21. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2005
    ..abstract_text> ..
  22. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
    ..A future study can be concentrated on the potential reflex pathways underlying spasms and their relation to hip extension (end of stance phase) during assisted locomotion in incomplete SCI patients. ..
  23. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  24. Ankle Tracking Training in Stroke
    James Carey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  26. rTMS and Motor Learning Training to Promote Recovery from Hemiparesis
    James Carey; Fiscal Year: 2009
    ..The potential impact of this research is a radical change to rehabilitation that accomplishes a higher quality of life in stroke. ..
  27. Mechanisms for Odor Coding in the Olfactory System
    Maksim Bazhenov; Fiscal Year: 2008
    ..Since neuronal oscillations and synchrony are observed in other sensory systems, the conclusions of this study might also provide insights into information processing in other brain areas. [unreadable] [unreadable] [unreadable]..
  28. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  29. Clustering and Synaptic Targeting of GABA-A Receptors
    Bernhard Luscher; Fiscal Year: 2006
    ..abstract_text> ..
  30. Protein Trafficking Regulating the Formation of GABAergic Synapses
    Bernhard Luscher; Fiscal Year: 2008
    Project Summary Neural inhibition by ?-aminobutyric acid (GABA) is vitally important for normal brain function as is evident from deficits in GABAergic transmission associated with a wide range of devastating neurological and psychiatric ..
  31. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  32. ANALYSES OF COMMUNICATION SOUNDS IN AUDITORY MIDBRAIN
    CHRISTINE PORTFORS; Fiscal Year: 2005
    ..This study will establish the extent of selectivity among social vocalizations in the IC and the contribution of combination sensitivity to selectivity. ..
  33. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  34. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  35. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  36. Analysis of the neural substrate of anxiety
    Bernhard Luscher; Fiscal Year: 2009
    ..Together these studies will greatly advance our undestanding of the mechanism underlying anxiety and depressive disorders. ..
  37. Post-natal neurogenesis in the turtle spinal cord
    RAUL RUSSO; Fiscal Year: 2009
    ..This knowledge is essential to understand basic neurogenic mechanisms that may remain "dormant" in the mammalian spinal cord but could hopefully be "awakened" to alleviate spinal cord diseases. ..
  38. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..Thus, new interventions that have the potential to reduce reliance on postoperative morphine in this patient population such as TMS need to be explored. ..
  39. BINOCULAR RIVALRY IN HUMAN VISION
    Robert Blake; Fiscal Year: 2009
    ..Finally, results from these experiments will guide neurophysiologists and cognitive neuroscientists seeking to discover the actual neural concomitants of multi-stable perception. ..
  40. DEVELOPMENT OF INHIBITATION IN THE AUDITORY SYSTEM
    Dan Sanes; Fiscal Year: 2004
    ..abstract_text> ..
  41. Push-pull Interactions Between ON and OFF Bipolar, Amacrine and Ganglion cells
    Frank S Werblin; Fiscal Year: 2011
    ....
  42. Effect of AADC gene transfer on L-dopa induced dyskinesia in MPTP monkeys
    Robert Richardson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Ion Channel Function in Auditory & Vestibular hair cells
    Jeffrey Holt; Fiscal Year: 2008
    ..Because deficiencies with these critical functions cause deafness and balance disorders, the information gained through these studies will facilitate design of rational strategies to treat genetic inner disorders. ..
  44. Cell Signaling and Dendritic Spine Plasticity
    Gang Yi Wu; Fiscal Year: 2009
    ....
  45. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    ..This work can define a new mitochondrial mechanism for target deprivation-induced neurodegeneration and can improve the understanding of the cellular and molecular mechanisms of neuronal apoptosis in vivo ..
  46. Cortical Excitability in Cocaine-Dependent Subjects
    Nashaat Boutros; Fiscal Year: 2009
    ..An additional exploratory aim is to probe the personality correlates of TMS-based cortical excitability changes in cocaine-dependent subjects. ..
  47. MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET
    JOSEPH MANDEVILLE; Fiscal Year: 2002
    ..Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology. ..
  48. DEVELOPMENT OF SENSORY/MOTOR SYNAPSES IN THE SPINAL CORD
    Eric Frank; Fiscal Year: 2005
    ....
  49. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2005
    ..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
  50. Interleukin-1Beta in Central Pain Modulating Circuits
    Mary Heinricher; Fiscal Year: 2004
    ..In providing additional tools to manipulate these systems, this work may ultimately lead to improved clinical treatment of pain. ..
  51. DYNAMICS OF NEURAL ACTIVITY IN THE CEREBELLUM
    Patrick Roberts; Fiscal Year: 2004
    ....
  52. Electrophysiological Action of GHB in Brain Reward Areas
    Vincenzo Crunelli; Fiscal Year: 2003
    ....
  53. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  54. NEURONAL ORGANIZATION OF BASAL GANGLIA
    Charles Wilson; Fiscal Year: 2003
    ..This latter will allow us to determine whether there is an actual mismatch between physiological and anatomical estimates of connectivity (i.e. non-functional synaptic connections). ..
  55. Properties of GABAc Receptors on Retinal Neurons
    Haohua Qian; Fiscal Year: 2005
    ..The information gained from these studies will enhance our knowledge about the physiological function of the GABA-C receptor in the retina, and broaden our understanding of retinal signal processing mechanisms. ..
  56. Mechanisms of Instructed Learning in the Auditory System
    ERIC KNUDSEN; Fiscal Year: 2006
    ..abstract_text> ..
  57. Brainstem Mechanisms of Rapid Eye Movement Sleep
    Gerald Marks; Fiscal Year: 2007
    ..Information concerning these control mechanisms are essential to understanding the physiological processes manifested during both normal and pathological sleep/wake states. ..
  58. 2008 Mechanisms of Epilepsy and Neuronal Synchronization GRC
    DOUGLAS COULTER; Fiscal Year: 2008
    ..This should significantly advance research directed towards better treatment of epilepsy. [unreadable] [unreadable] [unreadable]..
  59. ANALYSIS OF SPACE BY THE AUDITORY SYSTEM
    ERIC KNUDSEN; Fiscal Year: 2007
    ..abstract_text> ..
  60. Role of Endocannabinoid Signaling in Alcoholism
    BALAPAL BASAVARAJAPPA; Fiscal Year: 2007
    ..The better understanding of these mechanisms will yield new drug therapies with potential in treatment of alcoholism. ..
  61. Regulation of Hypothalamic Sleep-wake Neuronal System
    NOOR ALAM; Fiscal Year: 2008
    ..This will contribute to the search for more targeted and specific therapeutic strategies for sleep disorders. ..
  62. Dopamine modulation of network activity in the prefrontal cortex.
    Sven Kroener; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. Neurobiology of MIF in development and disease
    Bradley Pearce; Fiscal Year: 2007
    ..Besides schizophrenia, these studies could provide insight into Parkinson's disease, and maternal mental illnesses. [unreadable] [unreadable] [unreadable]..
  64. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  65. Sensory Gating in Schizophrenia: Multiple Measures
    Julie Patterson; Fiscal Year: 2004
    ....