- GABA A,slow: causes and consequences
MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
Trends Neurosci 34:101-12. 2011
- Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements
Hoi Chung Leung
Department of Psychology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
J Neurosci 27:9893-900. 2007
..Our findings suggest that a common VLPFC network is involved in response inhibition, although the specific control of the different response modalities may be partially segregated within the lateral prefrontal cortex...
- Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 104:14831-6. 2007
..These results reveal a form of GABA(A) receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition...
- Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn
David J Maxwell
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
J Physiol 584:521-33. 2007
..Our hypothesis appears to be correct only for islet cells. Other classes of cells have mixed actions, and in the case of vertical cells, the axonal projection appears to be a more important determinant of postsynaptic action...
- Interference resolution: insights from a meta-analysis of neuroimaging tasks
Derek Evan Nee
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
Cogn Affect Behav Neurosci 7:1-17. 2007
..Our analyses suggest that resolution processes acting upon stimulus encoding, response selection, and response execution may recruit different neural regions...
- Interneurons of the neocortical inhibitory system
Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Nat Rev Neurosci 5:793-807. 2004
..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
- Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Neurosci 6:215-29. 2005
..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
- Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
Scuola Normale Superiore, 56126 Pisa, Italy
J Neurosci 30:361-71. 2010
..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
- Gain modulation from background synaptic input
Frances S Chance
Center for Neural Science, New York University, New York, NY 10003, USA
Neuron 35:773-82. 2002
..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
- Cortical inhibitory neurons and schizophrenia
David A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Nat Rev Neurosci 6:312-24. 2005
..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
- BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
Z J Huang
Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 98:739-55. 1999
..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
- Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Science 293:1159-63. 2001
..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
- Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
Neuron 53:735-46. 2007
..We describe this feedback pathway and propose it as a central mechanism for regulation of cortical activity...
- Extrasynaptic GABAA receptors: form, pharmacology, and function
Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
J Neurosci 29:12757-63. 2009
..In addition, it emphasizes the important role of extrasynaptic GABA(A) receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes...
- Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 24:9598-611. 2004
- Neuronal circuits of the neocortex
Rodney J Douglas
Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
Annu Rev Neurosci 27:419-51. 2004
- GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
J Neurosci 28:4635-9. 2008
..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters...
- Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
Nat Neurosci 10:743-53. 2007
..These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell...
- GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 54:889-903. 2007
..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
- Tonically active GABA A receptors: modulating gain and maintaining the tone
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Trends Neurosci 27:262-9. 2004
- Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Neuron 47:423-35. 2005
..Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex...
- Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells
Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom
J Neurosci 30:9898-909. 2010
..Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex...
- Specific GABAA circuits for visual cortical plasticity
Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
Science 303:1681-3. 2004
..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
- Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 22:1328-37. 2002
..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity...
- Perisomatic inhibition
Tamas F Freund
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Neuron 56:33-42. 2007
..The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex...
- Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
Adam R Aron
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
Nat Neurosci 6:115-6. 2003
- Inhibition, spike threshold, and stimulus selectivity in primary visual cortex
Nicholas J Priebe
Section of Neurobiology, University of Texas at Austin, 1 University Station C0920, Austin, TX 78712, USA
Neuron 57:482-97. 2008
..e., spike threshold, contrast saturation, and spike-rate rectification) can account for properties that have previously appeared to require lateral inhibition...
- Two dynamically distinct inhibitory networks in layer 4 of the neocortex
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurophysiol 90:2987-3000. 2003
..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...
- Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasks
Institute of Psychiatry, King s College, London, UK
Neuroimage 13:250-61. 2001
- Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
Institute of Biotechnology, Department of Biological and Environmental Sciences, and Neuroscience Center, University of Helsinki, FIN 00014 Helsinki, Finland
J Neurosci 28:6996-7005. 2008
..This is likely mediated through BDNF itself, because injured neurons reverse their response to this neurotrophin by switching the BDNF-induced downregulation of KCC2 to upregulation...
- Fast-spike interneurons and feedforward inhibition in awake sensory neocortex
Harvey A Swadlow
Department of Psychology, The University of Connecticut, Storrs, CT 06269, USA
Cereb Cortex 13:25-32. 2003
..This fast, synchronous, highly sensitive and broadly tuned feed-forward inhibitory network is well suited to suppress spike generation in spiny neurons following all but the most optimal feedforward excitatory inputs...
- GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
INMED INSERM U901, Universite de la Mediterranee, Marseille, France
J Neurochem 110:1330-8. 2009
..Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons...
- Synaptic mechanisms of forward suppression in rat auditory cortex
Cold Spring Harbor Laboratory, New York 11724, USA
Neuron 47:437-45. 2005
- Synchronization in networks of excitatory and inhibitory neurons with sparse, random connectivity
Department of Mathematics, Tufts University, Medford, MA 02155, U S A
Neural Comput 15:509-38. 2003
..Faster decay yields tighter synchrony. In particular, in models in which the inhibitory synapses are assumed to be instantaneous, the effects of sparse, random connectivity cannot be seen...
- An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
J Neurophysiol 94:4491-501. 2005
..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
- Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
Neuron 48:315-27. 2005
..Hence, feed-forward inhibitory circuits, classically known to sharpen spatial contrast of tactile inputs, also increase the temporal resolution in the somatosensory cortex...
- Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
Scott J Cruikshank
Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
Nat Neurosci 10:462-8. 2007
..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
- Identified sources and targets of slow inhibition in the neocortex
Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
Science 299:1902-5. 2003
..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
- Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Nature 420:414-8. 2002
..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...
- Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
Edward O Mann
University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
Neuron 45:105-17. 2005
..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations...
- Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro
Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H 1450, Hungary
J Neurosci 24:9127-37. 2004
- Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
Colin J Akerman
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 26:5117-30. 2006
..Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit...
- Cortical plasticity induced by inhibitory neuron transplantation
Derek G Southwell
Department of Neurological Surgery and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Science 327:1145-8. 2010
..These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair...
- Dark rearing alters the development of GABAergic transmission in visual cortex
Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 22:8084-90. 2002
..Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits...
- Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
Sarah E Ross
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 65:886-98. 2010
..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
- The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:1356-65. 2008
..Our results thus reveal that the specific accumulation of GABA(A) receptor subtypes containing alpha2 subunits at inhibitory synapses is dependent on their ability to bind gephyrin...
- GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Nat Neurosci 6:484-90. 2003
..Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability...
- Functional dissociation in right inferior frontal cortex during performance of go/no-go task
Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
Cereb Cortex 19:146-52. 2009
..These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm...
- Major effects of sensory experiences on the neocortical inhibitory circuits
Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
J Neurosci 26:8691-701. 2006
..Together, these results suggest that the properties of local intracortical inhibitory networks are modified by sensory experiences. Perisomatic inhibition mediated by PV-positive basket cells is pruned by sensory deprivation...
- Modulation of neocortical interneurons: extrinsic influences and exercises in self-control
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Trends Neurosci 28:602-10. 2005
..We discuss how specificity of responses might differentially influence inhibition in somatodendritic compartments of pyramidal neurons and affect the balance of activities in neocortical circuits...
- GABAA receptor-mediated tonic inhibition in thalamic neurons
David W Cope
School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
J Neurosci 25:11553-63. 2005
..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
- Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
Nat Neurosci 4:52-62. 2001
..A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity...
- Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
R I Wilson
Nature 410:588-92. 2001
..Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs...
- Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
Anatomisches Institut, , Albertstr. 17, D-79104 Freiburg, Germany
Neuron 49:107-17. 2006
..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
- Postnatal differentiation of basket cells from slow to fast signaling devices
Physiologisches Institut I, Universitat Freiburg, D 79104 Freiburg, Germany
J Neurosci 28:12956-68. 2008
..Thus, late postnatal maturation of BCs enhances coherence in neuronal networks and will thereby contribute to the development of cognitive brain functions...
- Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
J Neurophysiol 87:2624-8. 2002
..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
- Trophic actions of GABA on neuronal development
INMED INSERM U29, Parc Scientifique et Technologique de Luminy, Marseille, France
Trends Neurosci 28:278-83. 2005
..This sequence also implies that by altering these effects, drugs acting on the GABA system could be pathogenic during pregnancy...
- Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice
Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506, USA
J Neurosci 26:5069-82. 2006
..We conclude that much of the variability previously attributed to neocortical SOM+ interneurons can be accounted for by their natural grouping into distinct subtypes...
- New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture
Neuroscience Programme, International School for Advanced Studies, 34014 Trieste, Italy
Neuroscience 164:552-62. 2009
..These results indicate that gephyrin is essential not only for maintaining synaptic GABA(A) receptor clusters in the right position but also for regulating both phasic and tonic inhibition...
- Tonic GABAergic control of mouse dentate granule cells during postnatal development
Nadine I Holter
Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
Eur J Neurosci 32:1300-9. 2010
..Thus, tonic inhibition is already functional at early developmental stages and plays a key role in regulating the excitation/inhibition balance of both the adult and the maturing dentate gyrus...
- Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
J Neurophysiol 101:1988-2001. 2009
..Thus olfactory bulb glomeruli contain at least two functionally distinct GABAergic circuits that may play different roles in olfactory coding...
- Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors
Murray B Herd
Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Eur J Neurosci 29:1177-87. 2009
..synaptic alpha(1)-subunit-containing GABA(A)Rs of thalamocortical neurones represent an important molecular target underpinning the sedative actions of THIP...
- Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 23:6315-26. 2003
- Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex
Sonja B Hofer
Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
Nat Neurosci 14:1045-52. 2011
..Therefore, feedforward and recurrent network influences determine the activity of excitatory and inhibitory ensembles in fundamentally different ways...
- Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells
C D Holmgren
Karolinska Institute, Department of Neuroscience, Division of Neuroanatomy and Brain Development, S-17177 Stockholm, Sweden
J Neurosci 21:8270-7. 2001
..Synaptic plasticity was not dependent on activation of GABA(B) receptors. It was also not affected by the antagonists of vesicular exocytosis, botulinum toxin D, and GDP-beta-S...
- GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex
Dipartimento di Neuroscienze, Universita Politecnica delle Marche, Ancona, Italy
J Neurochem 105:1781-93. 2008
- Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain
UCL Institute of Neurology, University College London, London WC1 N3BG, United Kingdom
J Neurosci 29:15341-50. 2009
- Phase dependent sign changes of GABAergic synaptic input explored in-silicio and in-vitro
Klaus M Stiefel
Max Planck Institute for Brain Research, Deutschordenstrasse 46, D-60528, Frankfurt/Main, Germany
J Comput Neurosci 19:71-85. 2005
..The results suggest that GABAergic mechanisms can assume highly specific timing functions in oscillatory networks...
- Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in synchronous release from hippocampal cholecystokinin interneurons
Michael I Daw
Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:11202-9. 2010
..This indicates that presynaptic KARs preserve and act in concert with asynchronous release to switch CCK interneurons from a phasic inhibition mode to produce prolonged inhibition during periods of intense activity...
- Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn
Spinal Cord Group, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
Neuroscience 156:193-202. 2008
..An alternative explanation for disinhibition after nerve injury is that it results from reduced excitatory drive to GABAergic dorsal horn neurons following loss of primary afferent input to these cells...
- Complementary modulation of somatic inhibition by opioids and cannabinoids
Lindsey L Glickfeld
Neurosciences Graduate Program, Neurobiology Section, University of California, San Diego, La Jolla, California 92093 0634, USA
J Neurosci 28:1824-32. 2008
..This cell-type specific sensitivity to neuromodulators allows for a fine control of the temporal structure of hippocampal activity...
- Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice
Luc J Gentet
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Neuron 65:422-35. 2010
..In contrast, inhibitory neurons fire correlated action potentials at much higher frequencies driven by slower, smaller, and broadly synchronized depolarization...
- Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 25:10016-24. 2005
..The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures...
- Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus
Miranda A Karson
Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
J Neurosci 29:4140-54. 2009
..The prevalence of CCK and PV networks in other brain regions suggests that internetwork interactions could be generally important...
- Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
Thomas K Berger
Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, Switzerland
J Physiol 587:5411-25. 2009
..Our results suggest that the basic construction of neocortical synaptic pathways follows principles that are independent of modality or hierarchical order within the neocortex...
- Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?
Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
J Neurosci 28:1421-6. 2008
..In conclusion, depending on the cell type, the alpha5 and delta subunits are the principal GABA(A)R subunits responsible for mediating the lion's share of tonic inhibition in hippocampal neurons...
- Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Physiol 581:603-18. 2007
..These results make it possible to identify primary afferent circuits associated with particular types of SG neurone...
- Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
J Neurophysiol 97:901-11. 2007
..We conclude that GABAergic DCN neurons are specialized to convey phasic spike rate information, whereas tonic spike rate is more faithfully relayed by the large non-GABAergic cells...
- Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Neurosci 11:535-7. 2008
- Functional selection of adaptive auditory space map by GABAA-mediated inhibition
Department of Neurobiology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
Science 284:962-5. 1999
..Thus, experience-driven changes in patterns of inhibition, as well as adjustments in patterns of excitation, can contribute critically to adaptive plasticity in the central nervous system...
- Network mechanisms of gamma oscillations in the CA3 region of the hippocampus
Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, Budapest, Hungary
Neural Netw 22:1113-9. 2009
- The olfactory bulb: coding and processing of odor molecule information
Laboratory for Neuronal Recognition Molecules, Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
Science 286:711-5. 1999
..They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex...
- GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development
Tue G Banke
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 26:11720-5. 2006
..Thus, in contrast to principal cells, inhibitory synaptic input onto CA3 interneurons remains shunting throughout development...
- Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
Nigel S Bamford
Department of Neurology, University of Washington, Children's Hospital and Regional Medical Center, Seattle, WA 98105 USA
Neuron 42:653-63. 2004
..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
- Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice
Centre for Brain Research, Department of Neurophysiology, Medical University Vienna, Spitalgasse 4, A-1090 Vienna, Austria
J Physiol 560:249-66. 2004
..These results provide a base to elucidate the functional roles of this subgroup of GABAergic lamina II neurones, e.g. for nociception...
- Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
Cereb Cortex 19:926-37. 2009
- Epilepsy following cortical injury: cellular and molecular mechanisms as targets for potential prophylaxis
David A Prince
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Epilepsia 50:30-40. 2009
..However, major issues such as the role of these processes in functional recovery from injury and the timing of the critical period(s) for application of potential therapies in humans need to be resolved...
- The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period
The Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 66:248-59. 2010
- Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
Tim P Vogels
Center for Neurobiology and Behavior, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
Nat Neurosci 12:483-91. 2009
..Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals...
- Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome
Department of Cell Biology, University of Valencia, Dr Moliner Street, 50, 46100 Burjassot, Valencia, Spain
J Neural Transm 117:445-55. 2010
- Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
University of Minnesota, Minneapolis, USA
Nat Neurosci 12:544-6. 2009
- Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent
Michael I Daw
Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:11112-22. 2009
- Inhibitory synaptic plasticity regulates pyramidal neuron spiking in the rodent hippocampus
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Neuroscience 155:64-75. 2008
..05), without changing the preferred phase of firing (P=0.783). This study provides the first explanation of how depolarizing E(GABA) affects pyramidal cell output within the hippocampus...
- Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex
Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Neurophysiol 94:2073-85. 2005
..Thus neocortical GAT-1 and GAT-2/3 have distinct but overlapping roles in modulating GABA conductances...
- Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Mol Pharmacol 59:814-24. 2001
..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
- Cholinergic synaptic potentials in the supragranular layers of auditory cortex
A E Bandrowski
Neuroscience Program, Department of Psychology, University of California, Riverside, California 92521, USA
Synapse 41:118-30. 2001
- From synchrony to sparseness
Frederic E Theunissen
Department of Psychology and Neuroscience Institute, University of California, Berkeley, USA
Trends Neurosci 26:61-4. 2003
..In this process, the neural representation of odor identity is transformed from a dense spatial-temporal code into a sparse code...
- Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 23:1622-30. 2003
..These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine...
- Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength
Gregory C Mathews
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4066, USA
J Neurosci 23:2040-8. 2003
..This modulation appears to occur under normal conditions and may constitute a negative feedback mechanism to combat hyperexcitability...
- Shunting inhibition modulates neuronal gain during synaptic excitation
Simon J Mitchell
Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Neuron 38:433-45. 2003
..Our results suggest that shunting inhibition can multiplicatively scale rate-coded information in neurons with high-variability synaptic inputs...
- GABA(B) receptor-mediated presynaptic inhibition has history-dependent effects on synaptic transmission during physiologically relevant spike trains
Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurosci 23:4809-14. 2003