GABA A,slow: causes and consequencesMarco Capogna
MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
Trends Neurosci 34:101-12. 2011
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Activation of postsynaptic GABAB receptors modulates the bursting pattern and synaptic activity of olfactory bulb juxtaglomerular neuronsNikolay Karpuk
Deptepartment of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Neurophysiol 99:308-19. 2008
..Thus the postsynaptic GABA(B)-Rs on ET cells may play an important role in shaping the activation pattern of the glomeruli during olfactory coding...
Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movementsHoi Chung Leung
Department of Psychology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
J Neurosci 27:9893-900. 2007
..Our findings suggest that a common VLPFC network is involved in response inhibition, although the specific control of the different response modalities may be partially segregated within the lateral prefrontal cortex...
- Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
Janos Szabadics
Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 104:14831-6. 2007
..These results reveal a form of GABA(A) receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition...
- Morphology of inhibitory and excitatory interneurons in superficial laminae of the rat dorsal horn
David J Maxwell
Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
J Physiol 584:521-33. 2007
..Our hypothesis appears to be correct only for islet cells. Other classes of cells have mixed actions, and in the case of vertical cells, the axonal projection appears to be a more important determinant of postsynaptic action...
- Specific GABAA circuits for visual cortical plasticity
Michela Fagiolini
Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
Science 303:1681-3. 2004
..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
- GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
Stanislav Khirug
Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
J Neurosci 28:4635-9. 2008
..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters...
- GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
Bidisha Chattopadhyaya
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 54:889-903. 2007
..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
- Perisomatic inhibition
Tamas F Freund
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Neuron 56:33-42. 2007
..The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex...
- Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
Bidisha Chattopadhyaya
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 24:9598-611. 2004
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- Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
Sarah E Ross
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 65:886-98. 2010
..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
- Synaptic mechanisms of forward suppression in rat auditory cortex
Michael Wehr
Cold Spring Harbor Laboratory, New York 11724, USA
Neuron 47:437-45. 2005
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- Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
Laetitia Gabernet
Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
Neuron 48:315-27. 2005
..Hence, feed-forward inhibitory circuits, classically known to sharpen spatial contrast of tactile inputs, also increase the temporal resolution in the somatosensory cortex...
- Interneurons of the neocortical inhibitory system
Henry Markram
Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Nat Rev Neurosci 5:793-807. 2004
..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
- Extrasynaptic GABAA receptors: form, pharmacology, and function
Delia Belelli
Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
J Neurosci 29:12757-63. 2009
..In addition, it emphasizes the important role of extrasynaptic GABA(A) receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes...
- Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
Scott J Cruikshank
Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
Nat Neurosci 10:462-8. 2007
..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
- Phase dependent sign changes of GABAergic synaptic input explored in-silicio and in-vitro
Klaus M Stiefel
Max Planck Institute for Brain Research, Deutschordenstrasse 46, D-60528, Frankfurt/Main, Germany
J Comput Neurosci 19:71-85. 2005
..The results suggest that GABAergic mechanisms can assume highly specific timing functions in oscillatory networks...
- Presynaptic kainate receptor activation preserves asynchronous GABA release despite the reduction in synchronous release from hippocampal cholecystokinin interneurons
Michael I Daw
Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Developmental Synaptic Plasticity Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:11202-9. 2010
..This indicates that presynaptic KARs preserve and act in concert with asynchronous release to switch CCK interneurons from a phasic inhibition mode to produce prolonged inhibition during periods of intense activity...
- GAT-1 regulates both tonic and phasic GABA(A) receptor-mediated inhibition in the cerebral cortex
Luca Bragina
Dipartimento di Neuroscienze, Universita Politecnica delle Marche, Ancona, Italy
J Neurochem 105:1781-93. 2008
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- Complementary modulation of somatic inhibition by opioids and cannabinoids
Lindsey L Glickfeld
Neurosciences Graduate Program, Neurobiology Section, University of California, San Diego, La Jolla, California 92093 0634, USA
J Neurosci 28:1824-32. 2008
..This cell-type specific sensitivity to neuromodulators allows for a fine control of the temporal structure of hippocampal activity...
- An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
Fan Jia
CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
J Neurophysiol 94:4491-501. 2005
..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
- Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn
E Polgar
Spinal Cord Group, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
Neuroscience 156:193-202. 2008
..An alternative explanation for disinhibition after nerve injury is that it results from reduced excitatory drive to GABAergic dorsal horn neurons following loss of primary afferent input to these cells...
- Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain
Ivan Pavlov
UCL Institute of Neurology, University College London, London WC1 N3BG, United Kingdom
J Neurosci 29:15341-50. 2009
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- Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice
Luc J Gentet
Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Neuron 65:422-35. 2010
..In contrast, inhibitory neurons fire correlated action potentials at much higher frequencies driven by slower, smaller, and broadly synchronized depolarization...
- Dark rearing alters the development of GABAergic transmission in visual cortex
Bernardo Morales
Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 22:8084-90. 2002
..Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits...
- Network mechanisms of gamma oscillations in the CA3 region of the hippocampus
Norbert Hajos
Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, Budapest, Hungary
Neural Netw 22:1113-9. 2009
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- Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
Michael Okun
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Neurosci 11:535-7. 2008
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- Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
Thomas K Berger
Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, Switzerland
J Physiol 587:5411-25. 2009
..Our results suggest that the basic construction of neocortical synaptic pathways follows principles that are independent of modality or hierarchical order within the neocortex...
- Morphological and electrophysiological properties of GABAergic and non-GABAergic cells in the deep cerebellar nuclei
Marylka Uusisaari
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
J Neurophysiol 97:901-11. 2007
..We conclude that GABAergic DCN neurons are specialized to convey phasic spike rate information, whereas tonic spike rate is more faithfully relayed by the large non-GABAergic cells...
- Functional selection of adaptive auditory space map by GABAA-mediated inhibition
W Zheng
Department of Neurobiology, Fairchild Science Building, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
Science 284:962-5. 1999
..Thus, experience-driven changes in patterns of inhibition, as well as adjustments in patterns of excitation, can contribute critically to adaptive plasticity in the central nervous system...
- Postnatal differentiation of basket cells from slow to fast signaling devices
Daniel Doischer
Physiologisches Institut I, Universitat Freiburg, D 79104 Freiburg, Germany
J Neurosci 28:12956-68. 2008
..Thus, late postnatal maturation of BCs enhances coherence in neuronal networks and will thereby contribute to the development of cognitive brain functions...
- Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?
Joseph Glykys
Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
J Neurosci 28:1421-6. 2008
..In conclusion, depending on the cell type, the alpha5 and delta subunits are the principal GABA(A)R subunits responsible for mediating the lion's share of tonic inhibition in hippocampal neurons...
- Synaptic cross talk between perisomatic-targeting interneuron classes expressing cholecystokinin and parvalbumin in hippocampus
Miranda A Karson
Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21210, USA
J Neurosci 29:4140-54. 2009
..The prevalence of CCK and PV networks in other brain regions suggests that internetwork interactions could be generally important...
- Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus
Annalisa Scimemi
Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 25:10016-24. 2005
..The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures...
- Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
Toshiharu Yasaka
Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Physiol 581:603-18. 2007
..These results make it possible to identify primary afferent circuits associated with particular types of SG neurone...
- Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
Colin J Akerman
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
J Neurosci 26:5117-30. 2006
..Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit...
- GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development
Tue G Banke
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 26:11720-5. 2006
..Thus, in contrast to principal cells, inhibitory synaptic input onto CA3 interneurons remains shunting throughout development...
- The olfactory bulb: coding and processing of odor molecule information
K Mori
Laboratory for Neuronal Recognition Molecules, Laboratory for Neurobiology of Synapse, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
Science 286:711-5. 1999
..They also mediate synchronized oscillatory discharges among specific combinations of output neurons and may contribute to the integration of signals from distinct odorant receptors in the olfactory cortex...
- GABAA receptor-mediated tonic inhibition in thalamic neurons
David W Cope
School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
J Neurosci 25:11553-63. 2005
..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
- Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
Nigel S Bamford
Department of Neurology, University of Washington, Children's Hospital and Regional Medical Center, Seattle, WA 98105 USA
Neuron 42:653-63. 2004
..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
- Physiological, neurochemical and morphological properties of a subgroup of GABAergic spinal lamina II neurones identified by expression of green fluorescent protein in mice
Bernhard Heinke
Centre for Brain Research, Department of Neurophysiology, Medical University Vienna, Spitalgasse 4, A-1090 Vienna, Austria
J Physiol 560:249-66. 2004
..These results provide a base to elucidate the functional roles of this subgroup of GABAergic lamina II neurones, e.g. for nociception...
- Interference resolution: insights from a meta-analysis of neuroimaging tasks
Derek Evan Nee
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
Cogn Affect Behav Neurosci 7:1-17. 2007
..Our analyses suggest that resolution processes acting upon stimulus encoding, response selection, and response execution may recruit different neural regions...
- Functional dissociation in right inferior frontal cortex during performance of go/no-go task
Junichi Chikazoe
Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
Cereb Cortex 19:146-52. 2009
..These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm...
- Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
Imre Vida
Anatomisches Institut, , Albertstr. 17, D-79104 Freiburg, Germany
Neuron 49:107-17. 2006
..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
- Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells
C D Holmgren
Karolinska Institute, Department of Neuroscience, Division of Neuroanatomy and Brain Development, S-17177 Stockholm, Sweden
J Neurosci 21:8270-7. 2001
..Synaptic plasticity was not dependent on activation of GABA(B) receptors. It was also not affected by the antagonists of vesicular exocytosis, botulinum toxin D, and GDP-beta-S...
- Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
Zoltan Nusser
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
J Neurophysiol 87:2624-8. 2002
..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
- Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons
D Bai
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Mol Pharmacol 59:814-24. 2001
..In summary, the receptors underlying the tonic current are functionally and pharmacologically distinct from quantally activated synaptic receptors and these receptors represent a novel target for neurodepressive drugs...
- Neuronal correlates of local, lateral, and translaminar inhibition with reference to cortical columns
Moritz Helmstaedter
Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse, Heidelberg, Germany
Cereb Cortex 19:926-37. 2009
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- Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
Mark Farrant
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Neurosci 6:215-29. 2005
..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
- Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
F Pouille
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Science 293:1159-63. 2001
..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
- Epilepsy following cortical injury: cellular and molecular mechanisms as targets for potential prophylaxis
David A Prince
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
Epilepsia 50:30-40. 2009
..However, major issues such as the role of these processes in functional recovery from injury and the timing of the critical period(s) for application of potential therapies in humans need to be resolved...
- Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
Tim P Vogels
Center for Neurobiology and Behavior, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
Nat Neurosci 12:483-91. 2009
..Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals...
- Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex
Sotirios Keros
Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Neurophysiol 94:2073-85. 2005
..Thus neocortical GAT-1 and GAT-2/3 have distinct but overlapping roles in modulating GABA conductances...
- Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome
D Pérez-Cremades
Department of Cell Biology, University of Valencia, Dr Moliner Street, 50, 46100 Burjassot, Valencia, Spain
J Neural Transm 117:445-55. 2010
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- Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons
Steve Davidson
University of Minnesota, Minneapolis, USA
Nat Neurosci 12:544-6. 2009
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- The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period
Bin Jiang
The Mind Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 66:248-59. 2010
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- GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
Sylvain Rheims
INMED INSERM U901, Universite de la Mediterranee, Marseille, France
J Neurochem 110:1330-8. 2009
..Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons...
- Inhibitory synaptic plasticity regulates pyramidal neuron spiking in the rodent hippocampus
F Saraga
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
Neuroscience 155:64-75. 2008
..05), without changing the preferred phase of firing (P=0.783). This study provides the first explanation of how depolarizing E(GABA) affects pyramidal cell output within the hippocampus...
- New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture
I Marchionni
Neuroscience Programme, International School for Advanced Studies, 34014 Trieste, Italy
Neuroscience 164:552-62. 2009
..These results indicate that gephyrin is essential not only for maintaining synaptic GABA(A) receptor clusters in the right position but also for regulating both phasic and tonic inhibition...
- Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
Gilad Silberberg
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
Neuron 53:735-46. 2007
..We describe this feedback pathway and propose it as a central mechanism for regulation of cortical activity...
- BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
Z J Huang
Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 98:739-55. 1999
..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
- Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
R Cossart
INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
Nat Neurosci 4:52-62. 2001
..A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity...
- Asynchronous transmitter release from cholecystokinin-containing inhibitory interneurons is widespread and target-cell independent
Michael I Daw
Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 29:11112-22. 2009
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- Galanin and galanin-like peptide differentially modulate neuronal activities in rat arcuate nucleus neurons
Yan Dong
Merck Research Laboratories, P O Box 2000 R80M213, Rahway, NJ 07065, USA
J Neurophysiol 95:3228-34. 2006
..Taken together, these differential effects of galanin and GALP may provide a neurophysiological mechanism through which galanin and GALP differentially regulate energy balance, reproductive function, and other physiological processes...
- Synaptic transmission at the calyx of Held under in vivo like activity levels
Joachim Hermann
Ludwig Maximilians University, Munich, Germany
J Neurophysiol 98:807-20. 2007
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- Striatal dysfunction increases basal ganglia output during motor cortex activation in parkinsonian rats
Mariano A Belluscio
Laboratorio de Fisiología de Circuitos Neuronales, Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay, Ciudad de Buenos Aires CP1121, Argentina
Eur J Neurosci 25:2791-804. 2007
..If a similar transient overactivity of basal ganglia output were driven by motor cortex input during movement, it could contribute to impeding movement initiation or execution in Parkinson's disease...
- Dual cholinergic control of fast-spiking interneurons in the neostriatum
Tibor Koos
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
J Neurosci 22:529-35. 2002
..In contrast, the muscarinic presynaptic inhibitory mechanism may be engaged primarily during longer-lasting elevations of extracellular acetylcholine levels...
- The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro
Frédéric Manseau
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
J Neurosci 28:4096-107. 2008
..Our data demonstrate that hippocamposeptal inhibition facilitates theta rhythmic discharges in MS/DB GABAergic neurons while favoring the inhibition of most ACh and glutamate neurons...
- Development of inhibitory synaptic transmission to the superior salivatory nucleus in rats
Yoshihiro Mitoh
Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Shikata cho, Okayama 700 8525, Japan
Brain Res 1191:47-54. 2008
..The development of SS neurons is discussed as compared with the development of peripheral salivary gland tissue and brainstem neurons that participate in oral motor and sensory functions...
- Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons
Ming Ren
Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
Science 316:758-61. 2007
..Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons...
- Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition
Thomas Heinbockel
Department of Anatomy, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA
J Neurophysiol 97:858-70. 2007
..Our results suggest that activation of mGluR5 participates in feedforward and/or feedback inhibition at mitral cell to GC dendrodendritic synapses, possibly to modulate lateral inhibition and contrast in the MOB...
- Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy
Chyze W Ang
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 26:11850-6. 2006
..This dysregulated temporoammonic pathway is critically positioned to mediate generation and/or propagation of seizure activity in the hippocampus...
- Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
Henrik Jörntell
Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
J Neurosci 26:11786-97. 2006
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- Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy
Philip de Guzman
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Hippocampus 16:843-60. 2006
..These findings identify an increase in network excitability within the subiculum of pilocarpine-treated, epileptic rats and point at a reduction in inhibition as an underlying mechanism...
- Driver or coincidence detector: modal switch of a corticothalamic giant synapse controlled by spontaneous activity and short-term depression
Alexander Groh
Department of Cell Physiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
J Neurosci 28:9652-63. 2008
..quot; Mechanisms decreasing spontaneous activity in L5B neurons and inputs synchronized by a sensory stimulus may thus gate the cortico-thalamo-cortical loop...
- Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses
Robert D Mair
Department of Molecular Pharmacology, Physiology and Biotechnology, Box G B4, Brown University, Providence, RI 02912, USA
Neuropharmacology 52:193-9. 2007
..Dysregulation of this mechanism could contribute to the impairment in cognitive performance associated with abnormal PFC dopamine receptor activation...
- Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse
Ethan M Goldberg
Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 25:5230-5. 2005
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- Physiological activity depresses synaptic function through an effect on vesicle priming
Krista L Moulder
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Neurosci 26:6618-26. 2006
..These results show that glutamatergic neurotransmission persistently adapts to changes in electrical activity over a wide physiological range...
- Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability
Katherine Jakubs
Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
Neuron 52:1047-59. 2006
..We demonstrate a high degree of plasticity in synaptic inputs to adult-born new neurons, which could act to mitigate pathological brain function...
- On the sensitive dependence on initial conditions of the dynamics of networks of spiking neurons
Arunava Banerjee
Computer and Information Science and Engineering Department, University of Florida, Gainesville, FL 32611 6120, USA
J Comput Neurosci 20:321-48. 2006
..Finally, we extend the formal result to networks driven by stationary input spike trains, deriving a superior criterion than previously reported...
- Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats
Van B Lu
Centre for Neuroscience and Department of Pharmacology, University of Alberta, Edmonton, Alta, Canada
Pain 121:261-75. 2006
..This validates their use in evaluating the cellular mechanisms that may contribute to the development of chronic pain...
- Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse
Stefan Hefft
, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany
Nat Neurosci 8:1319-28. 2005
..Asynchronous release occurs at physiological temperature and with behaviorally relevant stimulation patterns, thus generating long-lasting inhibition in the brain...
- Oscillations and sparsening of odor representations in the mushroom body
Javier Perez-Orive
Division of Biology, 139-74, California Institute of Technology, Pasadena, CA 91125, USA
Science 297:359-65. 2002
..These results provide direct support for the functional relevance of correlation codes and shed some light on the role of oscillatory synchronization in sensory networks...
- Electrophysiological analysis of suprachiasmatic nucleus projections to the ventrolateral preoptic area in the rat
X Sun
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7 Canada
Eur J Neurosci 14:1257-74. 2001
..These projections may play important roles in conveying circadian input to systems in the preoptic area that regulate sleep and waking...
- Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength
Gregory C Mathews
Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4066, USA
J Neurosci 23:2040-8. 2003
..This modulation appears to occur under normal conditions and may constitute a negative feedback mechanism to combat hyperexcitability...
- Long-term change in synaptic transmission in CA3 circuits followed by spontaneous rhythmic activity in rat hippocampal slices
K Nakashima
Department of Computer Science and Electronics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology, 820-8502, Iizuka, Japan
Neurosci Res 40:325-36. 2001
..These results suggest that LTP at the afferent synapses is not necessary to spontaneous epileptiform bursts in CA3, but LTP at excitatory synapses between CA3 pyramidal cells contribute to spontaneous epileptiform bursts...
- Shunting inhibition modulates neuronal gain during synaptic excitation
Simon J Mitchell
Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Neuron 38:433-45. 2003
..Our results suggest that shunting inhibition can multiplicatively scale rate-coded information in neurons with high-variability synaptic inputs...
- GABA(B) receptor-mediated presynaptic inhibition has history-dependent effects on synaptic transmission during physiologically relevant spike trains
Patricia Ohliger-Frerking
Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurosci 23:4809-14. 2003
....
- Distinguishing between presynaptic and postsynaptic mechanisms of short-term depression during action potential trains
Adrian Y C Wong
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, United Kingdom
J Neurosci 23:4868-77. 2003
....
- Differences in multiple forms of short-term plasticity between excitatory and inhibitory hippocampal neurons in culture
Michael P Kaplan
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Synapse 50:41-52. 2003
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- Pre- and postsynaptic contribution of GABAC receptors to GABAergic synaptic transmission in rat collicular slices and cultures
Sergei Kirischuk
Developmental Physiology, Johannes Muller Institute of Physiology, Humboldt University Medical School Charité, Tucholskystrasse 2, 10117 Berlin, Germany
Eur J Neurosci 18:752-8. 2003
..Thus, in GABAergic synapses of the SC GABACRs are involved in pre- and postsynaptic functions and may therefore contribute to the activity-dependent adjustment of GABAergic inhibition...
- Activation of group III metabotropic glutamate receptors presynaptically reduces both GABAergic and glutamatergic transmission in the rat globus pallidus
T Matsui
Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Memphis, 855 Monroe Avenue, Memphis, TN 38163, USA
Neuroscience 122:727-37. 2003
..L-AP4 failed to change iontophoretic glutamate induced responses. These results suggest that the subthalamo-pallidal glutamatergic input might homo- and hetero-synaptically control GABAergic and glutamatergic transmission in the GP...
- Coexistence of excitatory and inhibitory GABA synapses in the cerebellar interneuron network
Joël Chavas
Laboratoire de Physiologie Cérébrale, Universite Paris 5, 75270 Paris, France
J Neurosci 23:2019-31. 2003
..We suggest that the coexistence of excitatory and inhibitory GABA synapses could either buffer the mean firing rate of the interneuron network or introduce different types of correlation between neighboring interneurons, or both...
- Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex
Wen-Jun Gao
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 23:1622-30. 2003
..These findings provide evidence for both a dual mode of inhibition in prefrontal circuitry and circuit-dependent modulation by dopamine...
- From synchrony to sparseness
Frederic E Theunissen
Department of Psychology and Neuroscience Institute, University of California, Berkeley, USA
Trends Neurosci 26:61-4. 2003
..In this process, the neural representation of odor identity is transformed from a dense spatial-temporal code into a sparse code...
- Removal of GABAergic inhibition alters subthreshold input in neurons in forepaw barrel subfield (FBS) in rat first somatosensory cortex (SI) after digit stimulation
Cheng X Li
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
Exp Brain Res 145:411-28. 2002
..Possible corticocortical and thalamocortical substrates for subthreshold input to reach barrel neurons are discussed...
- Inhibition of spinal or hypoglossal motoneurons of the newborn rat by glycine or GABA
Cristina Marchetti
Biophysics Sector and INFM Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
Eur J Neurosci 15:975-83. 2002
..These results indicate that, immediately after birth, rat motoneurons were inhibited by synaptically released or exogenously applied GABA or glycine...
- Activity- and age-dependent GABAergic synaptic plasticity in the developing rat hippocampus
P Gubellini
, , Avenue de Luminy, BP 13, 13273 Marseille Cedex 09, France
Eur J Neurosci 14:1937-46. 2001
..It is suggested that such activity-induced modifications may represent a physiological mechanism for the functional maturation of GABAergic synaptic transmission...
- Gain modulation from background synaptic input
Frances S Chance
Center for Neural Science, New York University, New York, NY 10003, USA
Neuron 35:773-82. 2002
..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
- Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels
Eric M Slimko
Computation and Neural Systems Program and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 22:7373-9. 2002
..These experiments demonstrate the feasibility of using invertebrate ligand-activated Cl- channels as an approach to modulate excitability...
- Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex
Martine Hamann
Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
Neuron 33:625-33. 2002
..Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum...
