neural inhibition

Summary

Top Publications

  1. doi GABA A,slow: causes and consequences
    Marco Capogna
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Trends Neurosci 34:101-12. 2011
  2. ncbi Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
    Michael Okun
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Neurosci 11:535-7. 2008
  3. pmc Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
    Janos Szabadics
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:14831-6. 2007
  4. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
  5. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
  6. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  7. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
  8. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
  9. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
  10. ncbi Model of autism: increased ratio of excitation/inhibition in key neural systems
    J L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
    Genes Brain Behav 2:255-67. 2003

Detail Information

Publications267 found, 100 shown here

  1. doi GABA A,slow: causes and consequences
    Marco Capogna
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    Trends Neurosci 34:101-12. 2011
    ....
  2. ncbi Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities
    Michael Okun
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Neurosci 11:535-7. 2008
    ....
  3. pmc Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast
    Janos Szabadics
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 104:14831-6. 2007
    ..These results reveal a form of GABA(A) receptor mediated communication by a dedicated cell type that produces slow ionotropic responses with properties intermediate between phasic and tonic inhibition...
  4. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    ....
  5. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch...
  6. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  7. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
    ....
  8. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..These results suggest that, within active cortical circuits, the overall level of synaptic input to a neuron acts as a gain control signal that modulates responsiveness to excitatory drive...
  9. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
    ..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
  10. ncbi Model of autism: increased ratio of excitation/inhibition in key neural systems
    J L R Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, USA
    Genes Brain Behav 2:255-67. 2003
    ..Furthermore, the model suggests potential therapeutic interventions...
  11. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..Thus, intracortical inhibition is a crucial limiting factor for the induction of experience-dependent plasticity in the adult visual cortex...
  12. ncbi Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
    Adam R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Neurosci 6:115-6. 2003
  13. ncbi Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  14. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  15. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  16. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ....
  17. pmc Extrasynaptic GABAA receptors: form, pharmacology, and function
    Delia Belelli
    Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    J Neurosci 29:12757-63. 2009
    ..In addition, it emphasizes the important role of extrasynaptic GABA(A) receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes...
  18. pmc Highly selective receptive fields in mouse visual cortex
    Cristopher M Niell
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:7520-36. 2008
    ..This quantitative description of receptive field properties should facilitate the use of mouse visual cortex as a system to address longstanding questions of visual neuroscience and cortical processing...
  19. ncbi Inhibition, spike threshold, and stimulus selectivity in primary visual cortex
    Nicholas J Priebe
    Section of Neurobiology, University of Texas at Austin, 1 University Station C0920, Austin, TX 78712, USA
    Neuron 57:482-97. 2008
    ..e., spike threshold, contrast saturation, and spike-rate rectification) can account for properties that have previously appeared to require lateral inhibition...
  20. pmc Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    Alexander A Chubykin
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Neuron 54:919-31. 2007
    ..This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits...
  21. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
    ..These data show that through a highly sensitive recurrent inhibitory circuit, cortical excitability can be modulated by one pyramidal cell...
  22. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
    ..Taken together, our data reveal important chemical distinctions between mouse inhibitory cortical neurons and indicate that PV, SOM, and VIP can differentially label a majority of mouse inhibitory cortical neurons...
  23. pmc Inhibitory stabilization of the cortical network underlies visual surround suppression
    Hirofumi Ozeki
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 62:578-92. 2009
    ..We confirm two strong tests of this scenario experimentally and show through simulation that observed cell-to-cell variability in surround effects, from facilitation to suppression, can arise naturally from variability in the ISN...
  24. ncbi Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
    Andrea Hasenstaub
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 47:423-35. 2005
    ..Our results support the hypothesis that inhibitory networks are largely responsible for the dissemination of higher-frequency activity in cortex...
  25. ncbi Tonically active GABA A receptors: modulating gain and maintaining the tone
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Trends Neurosci 27:262-9. 2004
    ....
  26. ncbi Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  27. ncbi Neuroligin 2 is exclusively localized to inhibitory synapses
    Frederique Varoqueaux
    Max Planck Institute for Experimental Medicine, Department of Molecular Neurobiology, Gottingen, Germany
    Eur J Cell Biol 83:449-56. 2004
    ..Our findings identify neuroligin 2 as a new cell adhesion protein specific for inhibitory synapses and open new avenues for identifiying the constituents of this unique type of postsynaptic specialization...
  28. pmc Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  29. pmc Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex
    Aaron M Kerlin
    Department of Neurobiology, Harvard Medical School, Goldenson 243, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:858-71. 2010
    ..These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population--a principle that may generalize across species and sensory modalities...
  30. pmc Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex
    Caroline A Runyan
    Department of Brain and Cognitive Sciences and Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 67:847-57. 2010
    ..These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties...
  31. ncbi Synaptic mechanisms of forward suppression in rat auditory cortex
    Michael Wehr
    Cold Spring Harbor Laboratory, New York 11724, USA
    Neuron 47:437-45. 2005
    ....
  32. pmc Developmental sensory experience balances cortical excitation and inhibition
    Anja L Dorrn
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, and NeuroCure Neuroscience Research Center NWFZ, Berlin 13125, Germany
    Nature 465:932-6. 2010
    ..Thus, the pace of cortical synaptic receptive field development is set by progressive, experience-dependent refinement of intracortical inhibition...
  33. ncbi Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses
    Valerie Kilman
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:1328-37. 2002
    ..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity...
  34. ncbi Perisomatic inhibition
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Neuron 56:33-42. 2007
    ..The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex...
  35. ncbi Synchronization in networks of excitatory and inhibitory neurons with sparse, random connectivity
    Christoph Börgers
    Department of Mathematics, Tufts University, Medford, MA 02155, U S A
    Neural Comput 15:509-38. 2003
    ..Faster decay yields tighter synchrony. In particular, in models in which the inhibitory synapses are assumed to be instantaneous, the effects of sparse, random connectivity cannot be seen...
  36. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
  37. ncbi Neural mechanisms of orientation selectivity in the visual cortex
    D Ferster
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Annu Rev Neurosci 23:441-71. 2000
    ..The modified feed-forward and the feedback models ascribe fundamentally different functions to cortical processing...
  38. pmc Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
    Tim P Vogels
    Center for Neurobiology and Behavior, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 12:483-91. 2009
    ..Provided that the individual signals are detectable, detailed balance has a large capacity for gating multiple signals...
  39. ncbi Response facilitation and inhibition in subliminal priming
    Martin Eimer
    School of Psychology, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Biol Psychol 64:7-26. 2003
    ..Overall, results demonstrate that inhibitory mechanisms are involved in the control of response processes, even when motor activations are triggered by stimuli that are not accessible to conscious awareness...
  40. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
    ..Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability...
  41. ncbi Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area
    Christopher J Price
    Anatomical Neuropharmacology Unit, Medical Research Council, Oxford OX1 3TH, United Kingdom
    J Neurosci 25:6775-86. 2005
    ..Our data disclose a novel interneuronal network well suited for modulating the flow of information between the entorhinal cortex and CA1 hippocampus...
  42. pmc A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo
    Yuanyuan Jiao
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA
    Proc Natl Acad Sci U S A 108:12131-6. 2011
    ..These results suggest that postnatal experience, through activity-driven BDNF expression, controls cortical development by regulating FS cell-mediated perisomatic inhibition in vivo...
  43. doi Posttraumatic GABA(A)-mediated [Ca2+]i increase is essential for the induction of brain-derived neurotrophic factor-dependent survival of mature central neurons
    Anastasia Shulga
    Institute of Biotechnology, Department of Biological and Environmental Sciences, and Neuroscience Center, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:6996-7005. 2008
    ..This is likely mediated through BDNF itself, because injured neurons reverse their response to this neurotrophin by switching the BDNF-induced downregulation of KCC2 to upregulation...
  44. ncbi Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasks
    K Rubia
    Institute of Psychiatry, King s College, London, UK
    Neuroimage 13:250-61. 2001
    ....
  45. ncbi Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003
    ..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...
  46. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    ..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
  47. pmc Laminar specificity of functional input to distinct types of inhibitory cortical neurons
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:70-85. 2009
    ....
  48. pmc Activity-dependent gating of lateral inhibition in the mouse olfactory bulb
    ARMEN C AREVIAN
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Nat Neurosci 11:80-7. 2008
    ..These results show that this previously unknown mechanism for specifying lateral inhibitory connections allows functional inhibitory connectivity to be dynamically remapped to relevant populations of neurons...
  49. ncbi Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
    Michael A Nitsche
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075, Goettingen, Germany
    Clin Neurophysiol 114:600-4. 2003
    ..To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human...
  50. doi GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
    Sylvain Rheims
    INMED INSERM U901, Universite de la Mediterranee, Marseille, France
    J Neurochem 110:1330-8. 2009
    ..Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons...
  51. ncbi Fast-spike interneurons and feedforward inhibition in awake sensory neocortex
    Harvey A Swadlow
    Department of Psychology, The University of Connecticut, Storrs, CT 06269, USA
    Cereb Cortex 13:25-32. 2003
    ..This fast, synchronous, highly sensitive and broadly tuned feed-forward inhibitory network is well suited to suppress spike generation in spiny neurons following all but the most optimal feedforward excitatory inputs...
  52. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory...
  53. ncbi Switching from automatic to controlled action by monkey medial frontal cortex
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Neurosci 10:240-8. 2007
    ..Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected...
  54. ncbi Development of GABA innervation in the cerebral and cerebellar cortices
    Z J Huang
    Cold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Neurosci 8:673-86. 2007
    ..The cellular and molecular mechanisms that specify and modify inhibitory innervation patterns are only just beginning to be understood...
  55. ncbi GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
    Stanislav Khirug
    Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:4635-9. 2008
    ..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters...
  56. pmc GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 54:889-903. 2007
    ..Since intracellular GABA levels are modulated by neuronal activity, our results implicate GAD67-mediated GABA synthesis in activity-dependent regulation of inhibitory innervation patterns...
  57. ncbi Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro
    Norbert Hajos
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H 1450, Hungary
    J Neurosci 24:9127-37. 2004
    ....
  58. ncbi Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo
    Colin J Akerman
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 26:5117-30. 2006
    ..Therefore, depolarizing GABAergic transmission plays a pivotal role in the maturation of excitatory transmission and controls the balance of excitation and inhibition in the developing retinotectal circuit...
  59. ncbi Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
    Laetitia Gabernet
    Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Neuron 48:315-27. 2005
    ..Hence, feed-forward inhibitory circuits, classically known to sharpen spatial contrast of tactile inputs, also increase the temporal resolution in the somatosensory cortex...
  60. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations...
  61. ncbi An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
    Fan Jia
    CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Neurophysiol 94:4491-501. 2005
    ..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
  62. ncbi Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
    ..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...
  63. pmc Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
    Michael Brecht
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    J Physiol 543:49-70. 2002
    ..This presumably reflects the divergence of thalamocortical projections to different barrels. Septum cell PSPs preferably represent multiple whisker deflections, but less dynamically and with less spatial acuity...
  64. pmc Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
    X J Wang
    Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA
    Proc Natl Acad Sci U S A 101:1368-73. 2004
    ..This work suggests a framework for understanding the division of labor and cooperation among different inhibitory cell types in a recurrent cortical circuit...
  65. pmc Slow GABA transient and receptor desensitization shape synaptic responses evoked by hippocampal neurogliaform cells
    Theofanis Karayannis
    Medical Research Council Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, United Kingdom
    J Neurosci 30:9898-909. 2010
    ..Synaptic depression mediated by NGFCs is likely to play an important modulatory role in the feedforward inhibition of CA1 pyramidal cells provided by the entorhinal cortex...
  66. ncbi Dark rearing alters the development of GABAergic transmission in visual cortex
    Bernardo Morales
    Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 22:8084-90. 2002
    ..Thus, sensory experience appears to play a permissive role in the maturation of intracortical GABAergic circuits...
  67. ncbi Differential expression of muscarinic acetylcholine receptors across excitatory and inhibitory cells in visual cortical areas V1 and V2 of the macaque monkey
    Anita A Disney
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Comp Neurol 499:49-63. 2006
    ....
  68. ncbi Modulation of practice-dependent plasticity in human motor cortex
    U Ziemann
    Clinic of Neurology, J W Goethe University, Schleusenweg 2 16, D 60590 Frankfurt am Main, Germany
    Brain 124:1171-81. 2001
    ..We propose that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients...
  69. doi Dynamics of synaptic transmission between fast-spiking interneurons and striatal projection neurons of the direct and indirect pathways
    Henrike Planert
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci 30:3499-507. 2010
    ..Our findings show that the two intrastriatal inhibitory pathways have fundamentally different dynamic properties that are, however, similarly applied to both direct and indirect striatal projections...
  70. pmc Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons
    Scott J Cruikshank
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 65:230-45. 2010
    ..Thus, a major difference between thalamocortical and corticothalamic processing was the extent to which feedforward inhibitory neurons were themselves engaged by feedforward inhibition...
  71. pmc Cortical plasticity induced by inhibitory neuron transplantation
    Derek G Southwell
    Department of Neurological Surgery and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 327:1145-8. 2010
    ..These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair...
  72. doi The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin
    Verena Tretter
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:1356-65. 2008
    ..Our results thus reveal that the specific accumulation of GABA(A) receptor subtypes containing alpha2 subunits at inhibitory synapses is dependent on their ability to bind gephyrin...
  73. ncbi Major effects of sensory experiences on the neocortical inhibitory circuits
    Yuanyuan Jiao
    Department of Zoology and Physiology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Neurosci 26:8691-701. 2006
    ..Together, these results suggest that the properties of local intracortical inhibitory networks are modified by sensory experiences. Perisomatic inhibition mediated by PV-positive basket cells is pruned by sensory deprivation...
  74. doi Functional dissociation in right inferior frontal cortex during performance of go/no-go task
    Junichi Chikazoe
    Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
    Cereb Cortex 19:146-52. 2009
    ..These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm...
  75. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    ..We propose that BDNF promotes the maturation of cortical inhibition during early postnatal life, thereby regulating the critical period for visual cortical plasticity...
  76. pmc Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development
    Yujiao J Sun
    Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nature 465:927-31. 2010
    ..Our results suggest that functional refinement of cortical TRFs does not require a selective pruning of inputs, but may depend more on a fine adjustment of excitatory input strengths...
  77. ncbi Diverse types of interneurons generate thalamus-evoked feedforward inhibition in the mouse barrel cortex
    J T Porter
    Department of Neurobiology and Anatomy and the Sensory Neuroscience Research Center, West Virginia University, Morgantown, West Virginia 26506-9128, USA
    J Neurosci 21:2699-710. 2001
    ..We conclude that feedforward inhibition is generated by diverse classes of interneurons, possibly serving different roles in the processing of incoming sensory information...
  78. ncbi Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    Bradley E Alger
    Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Prog Neurobiol 68:247-86. 2002
    ..The study of the endocannabinoids can therefore serve as a model for the investigation of other putative messengers, and most attention is devoted to a discussion of systems that use these new messenger molecules...
  79. ncbi Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..We describe this feedback pathway and propose it as a central mechanism for regulation of cortical activity...
  80. ncbi Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
    R Cossart
    INMED, , Avenue de Luminy, B.P. 13, 13 273 Marseille Cedex 09, France
    Nat Neurosci 4:52-62. 2001
    ..A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity...
  81. ncbi Trophic actions of GABA on neuronal development
    Alfonso Represa
    INMED INSERM U29, Parc Scientifique et Technologique de Luminy, Marseille, France
    Trends Neurosci 28:278-83. 2005
    ..This sequence also implies that by altering these effects, drugs acting on the GABA system could be pathogenic during pregnancy...
  82. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    ..Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs...
  83. doi Postnatal differentiation of basket cells from slow to fast signaling devices
    Daniel Doischer
    Physiologisches Institut I, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 28:12956-68. 2008
    ..Thus, late postnatal maturation of BCs enhances coherence in neuronal networks and will thereby contribute to the development of cognitive brain functions...
  84. ncbi GABAA receptor-mediated tonic inhibition in thalamic neurons
    David W Cope
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 25:11553-63. 2005
    ..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
  85. ncbi Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
    ..Furthermore, we have identified distinct pharmacological tools to selectively modify tonic and phasic inhibitions, allowing future studies to investigate their specific roles in neuronal function...
  86. ncbi Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
    ..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
  87. ncbi Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition
    Bilal Haider
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:4535-45. 2006
    ....
  88. ncbi Modulation of neocortical interneurons: extrinsic influences and exercises in self-control
    Alberto Bacci
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Neurosci 28:602-10. 2005
    ..We discuss how specificity of responses might differentially influence inhibition in somatodendritic compartments of pyramidal neurons and affect the balance of activities in neocortical circuits...
  89. pmc Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons
    Susumu Koyama
    Department of Physiology and Biophysics M C 901 University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612 7342, USA
    J Neurophysiol 97:1977-85. 2007
    ....
  90. pmc Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells
    Bao Hua Liu
    Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA
    Neuron 71:542-54. 2011
    ....
  91. ncbi Balanced inhibition and excitation drive spike activity in spinal half-centers
    Rune W Berg
    Department of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen DK 2200 Copenhagen N, Denmark
    Science 315:390-3. 2007
    ..These findings show that balanced excitation and inhibition and irregular firing are fundamental motifs in certain spinal network functions...
  92. pmc Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity
    J M Fellous
    Computational Neurobiology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 122:811-29. 2003
    ..We conclude that background synaptic activity can dynamically modulate the input/output properties of individual neocortical neurons in vivo...
  93. pmc GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development
    Z Josh Huang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Curr Opin Neurobiol 18:77-83. 2008
    ..Defining the many steps from GABA signaling to receptor trafficking/stability and neuroligin function will provide further mechanistic insights into activity-dependent development and possibly plasticity of inhibitory synapses...
  94. pmc Neurogliaform cells and other interneurons of stratum lacunosum-moleculare gate entorhinal-hippocampal dialogue
    Marco Capogna
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    J Physiol 589:1875-83. 2011
    ....
  95. ncbi Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells
    C D Holmgren
    Karolinska Institute, Department of Neuroscience, Division of Neuroanatomy and Brain Development, S-17177 Stockholm, Sweden
    J Neurosci 21:8270-7. 2001
    ..Synaptic plasticity was not dependent on activation of GABA(B) receptors. It was also not affected by the antagonists of vesicular exocytosis, botulinum toxin D, and GDP-beta-S...
  96. doi Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex
    Sonja B Hofer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 14:1045-52. 2011
    ..Therefore, feedforward and recurrent network influences determine the activity of excitatory and inhibitory ensembles in fundamentally different ways...
  97. pmc Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals
    Z Shao
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
    J Neurophysiol 101:1988-2001. 2009
    ..Thus olfactory bulb glomeruli contain at least two functionally distinct GABAergic circuits that may play different roles in olfactory coding...
  98. pmc Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice
    Yunyong Ma
    Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia 26506, USA
    J Neurosci 26:5069-82. 2006
    ..We conclude that much of the variability previously attributed to neocortical SOM+ interneurons can be accounted for by their natural grouping into distinct subtypes...
  99. ncbi New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture
    I Marchionni
    Neuroscience Programme, International School for Advanced Studies, 34014 Trieste, Italy
    Neuroscience 164:552-62. 2009
    ..These results indicate that gephyrin is essential not only for maintaining synaptic GABA(A) receptor clusters in the right position but also for regulating both phasic and tonic inhibition...
  100. pmc Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors
    Murray B Herd
    Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Eur J Neurosci 29:1177-87. 2009
    ..synaptic alpha(1)-subunit-containing GABA(A)Rs of thalamocortical neurones represent an important molecular target underpinning the sedative actions of THIP...
  101. doi Tonic GABAergic control of mouse dentate granule cells during postnatal development
    Nadine I Holter
    Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Eur J Neurosci 32:1300-9. 2010
    ..Thus, tonic inhibition is already functional at early developmental stages and plays a key role in regulating the excitation/inhibition balance of both the adult and the maturing dentate gyrus...

Research Grants151 found, 100 shown here

  1. UBIQUITIN AND CELL COMMUNICATION IN EYE DEVELOPMENT
    Janice Fischer; Fiscal Year: 2001
    ..In the absence of FAF protein, an unknown neural inhibition pathway fails to function, resulting in disorganized retinas containing many ectopic photoreceptors...
  2. Computational Neural and Behavioral Studies of Competition-Dependent Learning
    Kenneth A Norman; Fiscal Year: 2010
    ..learning could be implemented in the brain by leveraging oscillations in the strength of neural inhibition;they also demonstrated that competition- dependent learning could account for detailed patterns of human ..
  3. Brain Imaging of Cocaine and Maternal Reward
    Marcelo Febo; Fiscal Year: 2010
    ....
  4. Axonal Signaling in the Hippocampus
    Steven J Mennerick; Fiscal Year: 2010
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  5. Alcohol and mesolimbic glutamatergic transmissions
    Jiang Hong Ye; Fiscal Year: 2010
    ..A better understanding of cellular mechanisms of alcohol addiction will improve the treatment and prevention of alcoholism. ..
  6. Spinal cord injury: Targeting local inhibition to improve outcome
    Arnold Kriegstein; Fiscal Year: 2009
    ..The primary medications used to treat spasticity either enhance neural inhibition or inhibit muscle contraction...
  7. Spinal cord injury: Targeting local inhibition to improve outcome
    Linda J Noble; Fiscal Year: 2010
    ..The primary medications used to treat spasticity either enhance neural inhibition or inhibit muscle contraction...
  8. ACOUSTIC BEHAVIOR--NEURAL AND COMPARATIVE BASES
    RONALD HOY; Fiscal Year: 2006
    ..system to determine: (1) Directional properties of auditory interneurons in the CNS; (2) The role of neural inhibition in shaping the directional responses in auditory interneurons; (3) How directional information in auditory ..
  9. ACOUSTIC BEHAVIOR--NEURAL AND COMPARATIVE BASES
    RONALD HOY; Fiscal Year: 2003
    ..system to determine: (1) Directional properties of auditory interneurons in the CNS; (2) The role of neural inhibition in shaping the directional responses in auditory interneurons; (3) How directional information in auditory ..
  10. ACOUSTIC BEHAVIOR--NEURAL AND COMPARATIVE BASES
    RONALD HOY; Fiscal Year: 2002
    ..system to determine: (1) Directional properties of auditory interneurons in the CNS; (2) The role of neural inhibition in shaping the directional responses in auditory interneurons; (3) How directional information in auditory ..
  11. ACOUSTIC BEHAVIOR--NEURAL AND COMPARATIVE BASES
    RONALD HOY; Fiscal Year: 2004
    ..system to determine: (1) Directional properties of auditory interneurons in the CNS; (2) The role of neural inhibition in shaping the directional responses in auditory interneurons; (3) How directional information in auditory ..
  12. ACOUSTIC BEHAVIOR--NEURAL AND COMPARATIVE BASES
    RONALD HOY; Fiscal Year: 2005
    ..system to determine: (1) Directional properties of auditory interneurons in the CNS; (2) The role of neural inhibition in shaping the directional responses in auditory interneurons; (3) How directional information in auditory ..
  13. NEURAL INHIBITION AND REM SLEEP DISORDERED BREATHING
    Joan Hendricks; Fiscal Year: 1990
    ..These studies should provide important information relating to the progression, pathophysiology and neurochemistry of SDB...
  14. Structural Requirements for Benzodiazepine Modulation of GABA-A Receptors
    Susan Hanson; Fiscal Year: 2007
    ..Alterations in GABAR-mediated neural inhibition have been linked to several disorders including epilepsy, schizophrenia, anxiety, and depression...
  15. Gene-based Neuromodulation: A New Paradigm for Functional Neurosurgery
    Nicholas Boulis; Fiscal Year: 2009
    ..to motor neurons and transgene delivery to axons, can improve the potency and specificity of LC gene-based neural inhibition. 3) The Rheoswitch(r) inducible expression system will improve controlled LC delivery. 4) Neuronal Kir2...
  16. Gene-based Neuromodulation: A New Paradigm for Functional Neurosurgery
    Nicholas M Boulis; Fiscal Year: 2010
    ..to motor neurons and transgene delivery to axons, can improve the potency and specificity of LC gene-based neural inhibition. 3) The Rheoswitch(r) inducible expression system will improve controlled LC delivery. 4) Neuronal Kir2...
  17. DEVELOPMENT/INFLUENCE--INHIBITION IN AUDITORY SYSTEM
    Dan Sanes; Fiscal Year: 1990
    The overall goal is to provide a comprehensive description of the functional and structural development of neural inhibition in a central auditory nucleus of the gerbil (Meriones unguiculatus)...
  18. DEVELOPMENT AND INFLUENCE OF INHIBITION IN THE AUDITORY
    Dan Sanes; Fiscal Year: 1993
    The overall goal is to provide a comprehensive description of the functional and structural development of neural inhibition in a central auditory nucleus of the gerbil (Meriones unguiculatus)...
  19. Computational Neural and Behavioral Studies of Competition-Dependent Learning
    Kenneth Norman; Fiscal Year: 2009
    ..learning could be implemented in the brain by leveraging oscillations in the strength of neural inhibition;they also demonstrated that competition- dependent learning could account for detailed patterns of human ..
  20. ANALYSIS OF NEURAL INHIBITION OF PITUITARY LH RELEASE
    James Johnson; Fiscal Year: 1980
    ..In addition, multiple unit activity recorded from the hippocampus and hypothalamus will be studied in response to activation of pathways ascending from the mesencephalon...
  21. UBIQUITIN AND CELL COMMUNICATION IN EYE DEVELOPMENT
    Janice Fischer; Fiscal Year: 2000
    ..In the absence of FAF protein, an unknown neural inhibition pathway fails to function, resulting in disorganized retinas containing many ectopic photoreceptors...
  22. UBIQUITIN AND CELL COMMUNICATION IN EYE DEVELOPMENT
    Janice Fischer; Fiscal Year: 1999
    ..In the absence of FAF protein, an unknown neural inhibition pathway fails to function, resulting in disorganized retinas containing many ectopic photoreceptors...
  23. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2008
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  24. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2002
    ....
  25. Neurotensin-1 Receptor as a Therapeutic Target for Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The proposed experiments may help lead to completely novel and superior treatments for schizophrenia. ..
  26. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2007
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  27. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2006
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  28. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  29. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  30. Neurotensin-1 Receptor as a Therapeutic Target for Schizophrenia
    David Feifel; Fiscal Year: 2010
    ..The proposed experiments may help lead to completely novel and superior treatments for schizophrenia. ..
  31. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2003
    ....
  32. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2005
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  33. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  35. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  36. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2003
    ..abstract_text> ..
  37. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2004
    ..abstract_text> ..
  38. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2002
    ..abstract_text> ..
  39. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2001
    ..abstract_text> ..
  40. Spinal interneurons: 5-HT-NA receptors, actions circuits
    Elzbieta Jankowska; Fiscal Year: 2010
    ..They should also link deficits in patients with different motor disorders and in motor behavior of genetically modified strains of animals to interrelations between spinal and supraspinal neuronal networks. ..
  41. SPINAL INTERNEURONS: 5HT-NA RECEPTORS, ACTIONS, CIRCUITS
    Elzbieta Jankowska; Fiscal Year: 2005
    ..Insights provided by the study will be important for the refinement and introduction of new therapeutic strategies for CNS repair, and also for the interpretation of results of molecular/genetic and in vitro studies of spinal functions. ..
  42. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 2000
    ....
  43. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 2003
    ..The roles of inhibition in this processing may be especially relevant for the decline of speech perception in the elderly, which is correlated with age related loss of GABAergic neurons in the auditory system. ..
  44. FUNCTIONAL ORGANIZATION OF THE INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 1992
    ....
  45. FUCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 1993
    ....
  46. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 1999
    ....
  47. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 2002
    ....
  48. In-Vivo Patch Clamp Studies of the Auditory Midbrain
    GEORGE POLLAK; Fiscal Year: 2007
    ....
  49. In-Vivo Patch Clamp Studies of the Auditory Midbrain
    GEORGE POLLAK; Fiscal Year: 2008
    ....
  50. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    Qian Quan Sun; Fiscal Year: 2008
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  51. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
    ..A future study can be concentrated on the potential reflex pathways underlying spasms and their relation to hip extension (end of stance phase) during assisted locomotion in incomplete SCI patients. ..
  52. Alcohol and mesolimbic glutamatergic transmissions
    Jiang Hong Ye; Fiscal Year: 2008
    ..A better understanding of cellular mechanisms of alcohol addiction will improve the treatment and prevention of alcoholism. ..
  53. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2004
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. ..
  54. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2009
    ..I-m), and testing time course of mGluR modulation of transmission in s. I-m. Understanding these mechanisms may assist in development of pharmacological treatments for Alzheimer's disease. ..
  55. Mechanisms of Entorhinal Cortex Function
    Michael Hasselmo; Fiscal Year: 2008
    ..Together these studies will assist in understanding the dynamic role of entorhinal cortex in representing environmental stimuli for active maintenance and encoding into episodic memory. ..
  56. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2005
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. ..
  57. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2009
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  58. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2008
    ..I-m), and testing time course of mGluR modulation of transmission in s. I-m. Understanding these mechanisms may assist in development of pharmacological treatments for Alzheimer's disease. ..
  59. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..
  60. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2007
    ..I-m), and testing time course of mGluR modulation of transmission in s. I-m. Understanding these mechanisms may assist in development of pharmacological treatments for Alzheimer's disease. ..
  61. Alcohol and mesolimbic glutamatergic transmissions
    Jiang Hong Ye; Fiscal Year: 2009
    ..A better understanding of cellular mechanisms of alcohol addiction will improve the treatment and prevention of alcoholism. ..
  62. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  63. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael E Hasselmo; Fiscal Year: 2010
    ....
  64. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2004
    ..Research could guide combined use of drugs influencing GABAb and ACh receptors. ..
  65. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2003
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. ..
  66. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2002
    ..abstract_text> ..
  67. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2000
    ..Research could guide combined use of drugs influencing GABAb and ACh receptors. ..
  68. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2000
    ....
  69. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2003
    ..Research could guide combined use of drugs influencing GABAb and ACh receptors. ..
  70. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2003
    ..abstract_text> ..
  71. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2002
    ....
  72. CHOLINERGIC REGULATION OF ENTORHINAL NETWORK FUNCTION
    Michael Hasselmo; Fiscal Year: 2001
    ..Understanding of the cellular effects of acetylcholine involved in these processes could allow targeting of specific receptor effects in the treatment of disorders. ..
  73. NEUROMODULATION AND CORTICAL MEMORY FUNCTION
    Michael Hasselmo; Fiscal Year: 2002
    ..Research could guide combined use of drugs influencing GABAb and ACh receptors. ..
  74. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  75. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 1999
    ....
  76. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2010
    ..In this proposal, we will study how gabapentin stimulates a natural pain-relief mechanism to reduce pain but also to cause side effects. ..
  77. Mechanism of Gabapentin Analgesia
    KENICHIRO HAYASHIDA; Fiscal Year: 2008
    ..We recently found that gabapentin activates a natural pain-relief mechanism, and in this proposal, we will study how gabapentin stimulates the body's own pain relieving system to work in chronic pain. ..
  78. NEURAL REGULATION OF VASOPRESSIN RELEASE
    J Cunningham; Fiscal Year: 2000
    ..Therefore, understanding the neural pathways involved in the arterial baroreceptor and atrial receptor regulation of vasopressin release is a necessary first step that is needed to address the role of vasopressin in health and disease. ..
  79. CONTROL OF SLEEP AND AROUSAL
    NOOR ALAM; Fiscal Year: 2001
    ..These pharmacological manipulations and analytical procedures will help understanding of the adenosinergic and GABAergic mechanisms that shape the discharge patterns of the MBF neurons across the sleep-waking cycle. ..
  80. Axonal Signaling in the Hippocampus
    Steven Mennerick; Fiscal Year: 2008
    ..Our results will also lead to cellular insights into the mechanism of brain stimulation techniques currently used in the treatment of movement disorders and neuropsychiatric disease. ..
  81. GENERATION AND DESCRIPTION OF DENDRITIC MORPHOLOGY
    Giorgio Ascoli; Fiscal Year: 2001
    ..We believe that this package, portable to all major platforms and freely distributed, will further neuroanatomy, computational modeling, and scientific education. ..
  82. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  83. Energy Balance in the Obese CCK-A Receptor Deficient Rat
    Timothy Moran; Fiscal Year: 2007
    ....
  84. DYNAMIC PATTERN ANALYSIS OF RETINAL FUNCTION
    Frank Werblin; Fiscal Year: 1999
    ..Analyses of these data will yield insights into the underlying neural mechanisms that mediate visual function and provide some clues about the strategies undertaken via neuronal interactions at each retinal level. ..