muscle tonus

Summary

Summary: The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)

Top Publications

  1. doi Tonic stretch reflex threshold as a measure of spasticity: implications for clinical practice
    Andra Calota
    School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Top Stroke Rehabil 16:177-88. 2009
  2. pmc KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle
    Shreena Joshi
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Pharmacol Exp Ther 329:368-76. 2009
  3. ncbi Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells
    Takashi Akata
    Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Anesth 21:232-42. 2007
  4. pmc Active medullary control of atonia in week-old rats
    K A Karlsson
    Program in Behavioral and Cognitive Neuroscience, Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 130:275-83. 2005
  5. doi An investigation into the agreement between clinical, biomechanical and neurophysiological measures of spasticity
    Shweta Malhotra
    Research Institute for Life Course Studies, University of Keele, Keele, UK
    Clin Rehabil 22:1105-15. 2008
  6. ncbi The effects of endogenous and exogenous nitric oxide on gut motility in zebrafish Danio rerio embryos and larvae
    Anna Holmberg
    Department of Zoophysiology, Goteborg University, Box 463, SE 405 30 Goteborg, Sweden
    J Exp Biol 209:2472-9. 2006
  7. ncbi Integrin-linked kinase regulates N-WASp-mediated actin polymerization and tension development in tracheal smooth muscle
    Wenwu Zhang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Biol Chem 282:34568-80. 2007
  8. ncbi Comparison of the tension responses to ramp shortening and lengthening in intact mammalian muscle fibres: crossbridge and non-crossbridge contributions
    H Roots
    Muscle Contraction Group, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Muscle Res Cell Motil 28:123-39. 2007
  9. ncbi Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins
    M Back
    Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, 177 77 Stockholm, Sweden
    Acta Physiol Scand 174:9-15. 2002
  10. ncbi [Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension]
    G H H Müller-Schwefe
    Regionales Schmerz und Palliativzentrum DGS, Goppingen
    MMW Fortschr Med 149:153-61. 2008

Research Grants

  1. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2007
  2. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 1993
  3. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTER
    Satish Rattan; Fiscal Year: 1992
  4. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2001
  5. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2010
  6. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2005
  7. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2002
  8. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2005
  9. Targeted microcarrier design and optimization
    David Eckmann; Fiscal Year: 2009
  10. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005

Detail Information

Publications194 found, 100 shown here

  1. doi Tonic stretch reflex threshold as a measure of spasticity: implications for clinical practice
    Andra Calota
    School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
    Top Stroke Rehabil 16:177-88. 2009
    ..We introduce a portable device to measure spasticity, based on the measurement of the tonic stretch reflex threshold, which is more closely related to Lance's definition...
  2. pmc KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle
    Shreena Joshi
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    J Pharmacol Exp Ther 329:368-76. 2009
    ..The pulmonary vasoconstrictor effect of KCNQ blockers is a potentially serious side effect, but the pulmonary vasodilator effect of the openers may be useful in the treatment of pulmonary hypertension...
  3. ncbi Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells
    Takashi Akata
    Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Anesth 21:232-42. 2007
    ....
  4. pmc Active medullary control of atonia in week-old rats
    K A Karlsson
    Program in Behavioral and Cognitive Neuroscience, Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 130:275-83. 2005
    ..All together, these findings demonstrate that muscle atonia is actively regulated very early in ontogeny...
  5. doi An investigation into the agreement between clinical, biomechanical and neurophysiological measures of spasticity
    Shweta Malhotra
    Research Institute for Life Course Studies, University of Keele, Keele, UK
    Clin Rehabil 22:1105-15. 2008
    ..To quantify agreement between three clinically usable methods of measuring spasticity...
  6. ncbi The effects of endogenous and exogenous nitric oxide on gut motility in zebrafish Danio rerio embryos and larvae
    Anna Holmberg
    Department of Zoophysiology, Goteborg University, Box 463, SE 405 30 Goteborg, Sweden
    J Exp Biol 209:2472-9. 2006
    ..p.f., and at 1 day later in the proximal intestine. In conclusion, the present study suggests that a nitrergic inhibitory tonus develops shortly before or at the time for onset of exogenous feeding...
  7. ncbi Integrin-linked kinase regulates N-WASp-mediated actin polymerization and tension development in tracheal smooth muscle
    Wenwu Zhang
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Biol Chem 282:34568-80. 2007
    ..We conclude that the recruitment of the ILK.PINCH.alpha-parvin complex to membrane adhesion complexes is required to initiate cytoskeletal processes required for tension development in smooth muscle...
  8. ncbi Comparison of the tension responses to ramp shortening and lengthening in intact mammalian muscle fibres: crossbridge and non-crossbridge contributions
    H Roots
    Muscle Contraction Group, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Muscle Res Cell Motil 28:123-39. 2007
    ....
  9. ncbi Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins
    M Back
    Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, 177 77 Stockholm, Sweden
    Acta Physiol Scand 174:9-15. 2002
    ....
  10. ncbi [Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension]
    G H H Müller-Schwefe
    Regionales Schmerz und Palliativzentrum DGS, Goppingen
    MMW Fortschr Med 149:153-61. 2008
    ..Thus, analgesics with muscle tone decreasing effects that apparently normalize increased muscle tonus through specific modes of action without disturbing normal muscular movement are an important therapeutic ..
  11. pmc Importance of vagal input in maintaining gastric tone in the dog
    F Azpiroz
    Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905
    J Physiol 384:511-24. 1987
    ..6. We conclude that gastric tone during fasting is maintained by a cholinergic input, which is vagally mediated at both the cervical and the supradiaphragmatic levels...
  12. ncbi Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi
    J L Ellis
    Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224
    Am J Respir Crit Care Med 149:118-22. 1994
    ..The results suggest that this tone is due to the continual production and release of histamine and cysteinyl-leukotrienes...
  13. pmc PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness
    Carlos Hidalgo
    Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA
    Circ Res 105:631-8, 17 p following 638. 2009
    ..Myocardial sarcomeres also contain a third myofilament, titin, and it is unknown whether titin can be phosphorylated by PKC and whether it affects passive tension...
  14. doi Spasticity, an impairment that is poorly defined and poorly measured
    S Malhotra
    School of Health and Rehabilitation and Research Institute for Life Course Studies, University of Keele, UK
    Clin Rehabil 23:651-8. 2009
    ..The congruence between the definitions of spasticity and the corresponding methods of measurement were also explored...
  15. ncbi Hypothalamic contribution to sleep-wake cycle development
    K A Karlsson
    Program in Behavioral and Cognitive Neuroscience, Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 123:575-82. 2004
    ..This circuit may represent a basic building block with which other sleep components become integrated during ontogeny...
  16. ncbi The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant rats
    Karl A E Karlsson
    Department of Psychology, University of Iowa, Iowa City 52242, USA
    Behav Neurosci 116:912-7. 2002
    ..Thus, MT during infancy occurs against a backdrop of muscle atonia, a result that is consistent with the view that AS is a developmental precursor of REM sleep...
  17. pmc A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease
    Roy Moncayo
    WOMED, Karl Kapferer Strasse 5, A 6020 Innsbruck, Austria
    BMC Musculoskelet Disord 8:17. 2007
    ..The aim of this study was to investigate this postulate by a musculoskeletal approach together with biochemical parameters...
  18. pmc Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate rats
    Boris Y Mileykovskiy
    Veterans Administration, Greater Los Angeles Health System, Sepulveda, California, USA
    J Physiol 545:997-1006. 2002
    ..These two mechanisms acting synergistically may cause generalized motor inhibition during REM sleep and cataplexy...
  19. ncbi Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries
    Guy Lagaud
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Am J Physiol Heart Circ Physiol 283:H2177-86. 2002
    ..These data indicate that gap junctions play an important role in the maintenance and modulation of membrane potential and tone in cerebral resistance arteries...
  20. ncbi Signaling through NO and cGMP-dependent protein kinases
    Jens Schlossmann
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
    Ann Med 35:21-7. 2003
    ..Activation of the NO/cGMP/cGKI pathway induces relaxation of smooth muscle by lowering the cytosolic calcium level and/or by calcium desensitization of the contractile elements...
  21. ncbi Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulation
    Satish Rattan
    Division of Gastroenterology and Hepatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Gastrointest Liver Physiol 287:G605-11. 2004
    ..The advent of CORM-1 with potent effects in the IAS has significant implications in anorectal motility disorders with regard to pathophysiology and therapeutic potentials...
  22. ncbi 17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation
    Jose A Ospina
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Am J Physiol Heart Circ Physiol 285:H241-50. 2003
    ..These effects of estrogen may contribute to the heightened thromboresistance and enhanced cerebral blood flow documented in pre-versus postmenopausal women...
  23. ncbi Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle
    Edmund Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Anesthesiology 102:117-24. 2005
    ..The authors questioned whether rapacuronium preferentially antagonized M2 versus M3 muscarinic receptors in intact airway...
  24. ncbi Static magnetic fields alter arteriolar tone in vivo
    Cassandra Morris
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Bioelectromagnetics 26:1-9. 2005
    ....
  25. ncbi Long-term outcomes of individualized biofeedback training based on the underlying dysfunction for patients with imperforate anus
    Yuan Zhengwei
    Department of Pediatric Surgery, Second Affiliated Hospital of China Medical University, Shenyang 110004, China
    J Pediatr Surg 40:555-61. 2005
    ..The aim of this study was to design an individualized biofeedback program based on the underlying dysfunctions and to assess the short-term and long-term clinical and quality-of-life outcomes for patients with imperforate anus...
  26. ncbi Adaptation of conduit artery vascular smooth muscle tone to induced hypertension
    P Fridez
    Laboratory of Hemodynamics and Cardiovascular Technology, Swiss Federal Institute of Technology, Lausanne
    Ann Biomed Eng 30:905-16. 2002
    ..The VSM tone returns back to normal levels once the slower geometrical and structural remodeling is developed sufficiently to restore the biomechanical environment and function of the arterial wall to control levels...
  27. ncbi Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsiveness
    Yanna D Rattmann
    Department of Pharmacology, Biological Sciences Sector, Universidade Federal of Paraná, Curitiba, Brazil
    J Ethnopharmacol 100:268-75. 2005
    ....
  28. ncbi A new model for the immobilization of the rat hind limb
    E L Coutinho
    Unidade de Plasticidade Muscular, Laboratorio de Neurociencias, Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brasil
    Braz J Med Biol Res 35:1329-32. 2002
    ..Immobilization was effective in producing chronic muscle disuse in the hind limbs of rats and is an acceptable alternative to the traditional methods of immobilization such as cast or plaster cast...
  29. ncbi Modulatory effect of repetitive peripheral magnetic stimulation on skeletal muscle tone in healthy subjects: stabilization of the elbow joint
    Albrecht Struppler
    Sensorimotor Integration Research Group, Psychiatrische Klinik 7 0, Klinikum rechts der Isar der TUM, Ismaningerstr 22, 81675 Munchen, Germany
    Exp Brain Res 157:59-66. 2004
    ..Therefore RPMS is involved in sensorimotor integration and may modulate the motor program at the cortical level...
  30. ncbi ATP concentrations and muscle tension increase linearly with muscle contraction
    Jianhua Li
    Division of Cardiology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Appl Physiol (1985) 95:577-83. 2003
    ..Thus ATPi is not largely released from sympathetic or motor nerves and does not require an intact afferent reflex pathway. We conclude that ATPi is due to the release of ATP from contracting skeletal muscle cells...
  31. ncbi Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical stimulation
    Adebowale Adebiyi
    Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Clin Exp Pharmacol Physiol 31:82-5. 2004
    ..4. The results of the present study suggest that caffeine exhibits relaxant activity on rabbit cavernosal smooth muscle and the mechanism of this activity possibly involves inhibition of Ca2+ signalling...
  32. pmc Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats
    Mahua Ghosh
    Department of Pharmacology and the Cardiovascular Risk Factor Reduction Unit, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
    Br J Pharmacol 141:562-73. 2004
    ..NADPH-oxidase-derived O(2)(-) enhanced spontaneous tone by inactivating NO. Endogenous H(2)O(2) appears to mitigate the increase in tone. In addition, a COX component may also contribute to spontaneous tone...
  33. ncbi Different responsiveness of excitatory and inhibitory enteric motor neurons in the human esophagus to electrical field stimulation and to nicotine
    Asensio A Gonzalez
    Fundació de Gastroenterologia Dr Francisco Vilardell, 08025 Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 287:G299-306. 2004
    ....
  34. ncbi Myogenic tone and reactivity of the rat ophthalmic artery
    Yagna P R Jarajapu
    Department of Pharmacology and Therapeutics, Vascular Biology and Cell Physiology Group, College of Medicine, University of Florida, Gainesville, Florida 32610 0267, USA
    Invest Ophthalmol Vis Sci 45:253-9. 2004
    ..To study and quantify myogenic behavior and reactivity of the rat ophthalmic artery to pressure and different vasoactive substances in vitro...
  35. ncbi Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells
    Rowland W Rees
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Urol 170:2517-22. 2003
    ..Therefore, we investigated the effect of Y-27632 on prostatic smooth muscle proliferation and tone...
  36. ncbi Is the mitral valve passive flap theory overstated? An active valve is hypothesized
    T H Williams
    Department of Anatomy and Cell Biology, University of Iowa, 1 449 Bowen Science Building, Iowa City, IA 52242, USA
    Med Hypotheses 62:605-11. 2004
    ....
  37. ncbi Physiology and biochemistry of erections
    George J Christ
    Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Endocrine 23:93-100. 2004
    ..This article reviews fundamental aspects of the physiology of erection and summarizes the most recent information available concerning the putative biochemical correlates of these physiologic events...
  38. ncbi Differences in hamstring muscle stretching of elite field hockey players and normal subjects
    M Jaeger
    Department of Orthopaedic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Sportverletz Sportschaden 17:65-70. 2003
    ..To investigate differences in stretching behaviour of hamstring muscles in elite field hockey players and normal subjects...
  39. ncbi Hypotensive effect of butein via the inhibition of angiotensin converting enzyme
    Dae Gill Kang
    Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Biol Pharm Bull 26:1345-7. 2003
    ..These results suggest that butein has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme...
  40. ncbi Mechanical properties of rat middle cerebral arteries with and without myogenic tone
    Rebecca J Coulson
    Mechanical Engineering Department, University of Vermont, Burlington, VT 05405, USA
    J Biomech Eng 126:76-81. 2004
    ..Einc-a (10(6) dynes/cm2) increased significantly with pressure (from 15.1 +/- 2.3 at 75 mmHg to 49.4 +/- 12.6 at 125 mmHg, p < 0.001), indicating a greater contribution of SMC activity to vessel wall stiffness at higher pressures...
  41. ncbi Change of stretch reflex threshold in spasticity: effect of botulinum toxin injections
    G Stampacchia
    Dipartimento di Neuroscienze, Neuroriabilitazione, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Arch Ital Biol 142:265-73. 2004
    ..This effect explains how Botulinum toxin increases the stretch reflex threshold in spastic muscles...
  42. ncbi Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing
    Alan L Peterson
    Circulation 107:e198; author reply e198. 2003
  43. ncbi Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
    Anesthesiology 98:1372-7. 2003
    ..General anesthesia may delay the onset of movement in response to noxious stimulation. The authors hypothesized that the production of immobility could involve depression of time-related processes involved in the generation of movement...
  44. pmc Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle
    Jurgen W G E VanTeeffelen
    The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
    J Physiol 550:563-74. 2003
    ..Such concerted interaction will promote oxygen extraction when blood flow is restricted to maintain arterial pressure...
  45. ncbi Role of PKCalpha and PKCiota in phenylephrine-induced contraction of rat corpora cavernosa
    S Husain
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Int J Impot Res 16:325-33. 2004
    ..0 +/- 0.8 microM vs phenylephrine + chelerythrine chloride 5.7 +/- 2.4 microM). Based on these results, we suggest a potential role for PKCalpha and PKCiota in phenylephrine-induced smooth muscle tone of the rat cavernosum...
  46. ncbi 5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colon
    Makoto Kadowaki
    Department of Physiology II, Nara Medical University, Kashihara, Japan
    Auton Neurosci 99:62-5. 2002
    ..0 cm H2O (n = 8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon...
  47. ncbi Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 42:171-87. 2006
    ..These results suggest that in the STZ-induced diabetic perfused kidney, vasorelaxant metabolites derived from AA (probably COX and/or CYP450 metabolites) are increased, and may serve to regulate vascular tone...
  48. ncbi Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:107-16. 2005
    ..We speculate that a major factor mediating the relaxant action of PDBu in rat stomach fundus smooth muscle is represented by a reduction in Ca2+ influx via an inhibition of Ca2+ channels...
  49. ncbi [Modern concept of peripheral erectile mechanisms]
    M I Boiko
    Institute of Urology and Nephrology, Academy of Medical Sciences of Ukraine, Kiev
    Fiziol Zh 47:116-32. 2001
    ..A better understanding of the peripheral pharmacology of erection opens the way to new pathophysiological and therapeutic prospects in the broad context of erectile dysfunction...
  50. ncbi Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteries
    Narihiro Yoshinaga
    Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 146:478-83. 2007
    ..Endothelial cells might play an important role in the responsiveness of snake basilar arteries to rattlesnake BK, but they might not be involved in the responsiveness to ACh, BK and in resting vascular tone...
  51. pmc Comparison of U46619-, endothelin-1- or phenylephrine-induced changes in cellular Ca2+ profiles and Ca2+ sensitisation of constriction of pressurised rat resistance arteries
    Linda Shaw
    Smooth Muscle Physiology Group, Cardiovascular Research, University of Manchester, Manchester
    Br J Pharmacol 141:678-88. 2004
    ....
  52. ncbi The effect of creatine supplementation on mass and performance of rat skeletal muscle
    Robert E Young
    Department of Kinesiology, University of Nevada, Las Vegas, Las Vegas, NV 89154, United States
    Life Sci 81:710-6. 2007
    ....
  53. ncbi Effects of spermine on the relaxation response of rat detrusor smooth muscles
    Soon Chul Myung
    Department of Urology and Physiology, Chung Ang University, College of Medicine, Dongjak Gu, Huksuk Dong 221, Seoul, South Korea
    Eur J Pharmacol 573:196-200. 2007
    ..We concluded that spermine exerts a potent relaxant effect on rat bladder smooth muscle, and this effect appears to be mediated by calcium channel antagonism...
  54. ncbi Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels
    Pedro Marcos G Soares
    Instituto Superior de Ciências Biomédicas, ISCB CCS, Universidade Estadual do Ceara, Av Paranjana 1700, 60740 000, Fortaleza CE, Brazil
    Life Sci 81:1085-93. 2007
    ....
  55. ncbi Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteries
    G J Lagaud
    Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
    Biochem Biophys Res Commun 257:523-7. 1999
    ..However, our results also demonstrate that PD98059 may have nonspecific effects on voltage-sensitive Ca2+ entry in vascular smooth muscle...
  56. doi AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
    Sandrine Horman
    Hormone and Metabolic Research Unit, de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels
    J Biol Chem 283:18505-12. 2008
    ..The findings suggest that AMPK attenuates contraction by phosphorylating and inactivating MLCK. This might contribute to reduced ATP turnover in the tonic phase of smooth muscle contraction...
  57. pmc Non-adrenergic, non-cholinergic neural activation in guinea-pig bronchi: powerful and frequency-dependent stabilizing effect on tone
    A Linden
    Division of Pulmonary Medicine, Renströmska Hospital, University of Goteborg, Sweden
    Br J Pharmacol 109:845-51. 1993
    ..Our findings are consistent with a regulatory role for NANC responses in the control of bronchial smooth-muscle tone...
  58. ncbi Endothelium-dependent blunting of myogenic responsiveness after chronic hypoxia
    Scott Earley
    Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131 5218, USA
    Am J Physiol Heart Circ Physiol 283:H2202-9. 2002
    ..We conclude that blunted myogenic reactivity after chronic hypoxia results from a non-NO, endothelium-dependent VSM cell hyperpolarizing influence...
  59. doi The investigation of putative agents, using an in vitro model, to prevent cavernosal smooth muscle dysfunction during low-flow priapism
    Asif Muneer
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    BJU Int 102:988-92. 2008
    ....
  60. ncbi Changes in muscle tone are regulated by D1 and D2 dopamine receptors in the ventral striatum and D1 receptors in the substantia nigra
    K M Hemsley
    Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University of South Australia, Bedford Park, Australia
    Neuropsychopharmacology 25:514-26. 2001
    ..Overall the results support roles for dopamine D1 and D2 receptors in the ventral striatum, and D1 receptors in the substantia nigra, in the regulation of muscle tone...
  61. ncbi Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice
    John N Lorenz
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Regul Integr Comp Physiol 292:R440-6. 2007
    ..This is mediated, at least in part, through an effect on the endothelium, but direct effects on vascular smooth muscle cannot be ruled out and require further investigation...
  62. ncbi Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the rat
    Kim M Hemsley
    Department of Clinical Pharmacology and Centre for Neuroscience, The Flinders University of South Australia, Bedford Park SA 5042, Australia
    Neurosci Lett 317:123-6. 2002
    ..These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone...
  63. ncbi Kinetics of restoration of arteriolar tone after exercise
    Thomas J Barstow
    J Appl Physiol 99:775. 2005
  64. ncbi Activation of the midbrain periaqueductal gray induces airway smooth muscle relaxation
    Musa A Haxhiu
    Department of Physiology and Biophysics, College of Medicine Howard University and Specialized Neuroscience Research Program of Howard University, Washington, DC 20059, USA
    J Appl Physiol 93:440-9. 2002
    ..These data indicate, for the first time, that activation of vl PAG dilates the airways by a release of GABA and activation of GABA(A) receptors expressed by AVPNs...
  65. ncbi Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker
    Richard H Kennedy
    Department of Pharmaceutical Sciences and Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas, USA
    Clin Exp Pharmacol Physiol 33:340-4. 2006
    ..However, the relatively minor antagonistic action of SPT on the inotropic effect of homocysteine suggests that additional endothelium-derived mediators underlie its effects on contractility...
  66. ncbi Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla
    Boris Y Mileykovskiy
    Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg 194223, Russia
    J Neurophysiol 87:2480-9. 2002
    ..Loss of OX function may, therefore, disturb both muscle tone facilitatory and inhibitory processes at the medullary level...
  67. pmc Regulation of human penile smooth muscle tone by prostanoid receptors
    Javier Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Br J Pharmacol 136:23-30. 2002
    ..TP-receptors mediate contraction in HCCS and HPRA, while the relaxant effects of prostanoids are mediated by EP2- and/or EP4-receptors in HCCS and by EP- and IP-receptors in HPRA...
  68. ncbi Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle
    Chirag A Patel
    Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 1025 Walnut St, Rm 901, Philadelphia, PA 19107, USA
    Am J Physiol Gastrointest Liver Physiol 291:G830-7. 2006
    ..We conclude that RhoA/ROK plays a critical role in the basal tone in the IAS by the inhibition of MLC phosphatase via the phosphorylation of MYPT1 and CPI-17...
  69. ncbi Effect of pH changes on reactivity of rat mesenteric artery segments at different magnitude of stretch
    V N Yartsev
    Laboratory of Circulation, Pavlov Institute of Physiology, nab Makarova 6, St Petersburg, 199034, Russia
    Acta Physiol Scand 174:1-7. 2002
    ..In addition, it was shown that acidosis is able to act not only as the commonly known dilator agent, but also as an agent potentiating constriction in case of the high noradrenaline-induced tone...
  70. ncbi [Secretory function of the endothelium as a factor of vascular tone regulation in the norm and in cardiovascular pathology]
    N A Medvedeva
    M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia
    Ross Fiziol Zh Im I M Sechenova 87:1518-26. 2001
    ..The altered interrelationships between the endothelium-derived vasoactive substances may precede pathological shifts in the cardiovascular system...
  71. pmc Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction
    M M Lalu
    Department of Pharmacology, Cardiovascular Research Group, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Br J Pharmacol 149:31-42. 2006
    ..This possibility was tested in rat aortic tissue...
  72. ncbi Interindividual differences in H reflex modulation during normal walking
    Erik B Simonsen
    Institute of Medical Anatomy, The Panum Institute, University of Copenhagen, Blegdamsvej 3C, 2200 Copenhagen N, Denmark
    Exp Brain Res 142:108-15. 2002
    ..Alternatively, in subjects with a suppressed H reflex in the swing phase the knee joint extensors seem to form the primary protection around heel strike...
  73. ncbi [The role of stimulation parameters of sympathetic nerves in regulation of microvessel tone in the rat stomach]
    M V Lentsman
    I. P. Pavlov Institute of Physiology, Russian Acad. Sci, St. Petersburg, 199034, Nab. Makarova, Russia
    Ross Fiziol Zh Im I M Sechenova 87:1402-12. 2001
    ..Thereupon, an efficient control of microvascular tone can be achieved by grouping the pulses into bursts or by an increase of the burst rate or duration...
  74. ncbi [Contractile function of vessel myocytes: dependence on the stretch magnitude]
    D P Dvoretskii
    I P Pavlov Institute of Physiology, Russian Acad Sci, St Petersburg, 199034, Nab Makarova, 6, Russia
    Ross Fiziol Zh Im I M Sechenova 87:1318-24. 2001
    ..The findings show that the magnitude of stretch corresponding to the maximal effect depend on the character of responses, on the factor, and on the responses occurrence conditions...
  75. pmc Neuropeptide Y in rat detrusor and its effect on nerve-mediated and acetylcholine-evoked contractions
    M M Iravani
    Department of Pharmacological Sciences, Medical School, Newcastle upon Tyne
    Br J Pharmacol 113:95-102. 1994
    ..Keywords: Detrusor muscle; urinary bladder; neuropeptide Y; cholinergic neurotransmission; non-cholinergic neurotransmission;nifedipine..
  76. ncbi Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle
    Takio Kitazawa
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069 8501, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:503-13. 2008
    ..Carbachol (10 nM-100 microM) increased muscle tonus and phasic contractile activity of uterine strips of control mice in a concentration-dependent manner...
  77. ncbi Inhibitory actions of dopamine on Limulus visceral muscle involve a cyclic AMP-dependent mechanism
    J R Groome
    Zoology Department, University of New Hampshire, Durham 03824
    J Comp Physiol A 170:787-95. 1992
    ..2. Catecholamines decreased muscle tonus and inhibited spontaneous contractions of the Limulus midgut...
  78. ncbi [Cervicogenic proprioceptive vertigo: etiopathogenesis, clinical manifestations, diagnosis and therapy with special emphasis on manual therapy]
    Vjekoslav Grgic
    Lijec Vjesn 128:288-95. 2006
    ..Hyperactivity of craniocervical mechanoreceptors also causes disturbances in reflex regulation of postural muscle tonus manifesting as "general instability"...
  79. ncbi Arousal systems
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Front Biosci 8:s438-51. 2003
    ..low frequency rhythmic theta activity, and through descending projections to the spinal cord, they stimulate muscle tonus along with sensory-motor responsiveness and activity...
  80. ncbi The effect of biofeedback physical therapy in men with Chronic Pelvic Pain Syndrome Type III
    Erik B Cornel
    Department of Urology, Ziekenhuis Groep Twente location SMT, P O Box 546, 7550 AM Hengelo, The Netherlands
    Eur Urol 47:607-11. 2005
    ..The objective of this study was to evaluate the effect of biofeedback physical therapy on the symptoms of men with CPPS...
  81. ncbi Effects of electrical stimulation of the sciatic nerve on background electromyography and static stretch reflex activity of the trunk muscles in rats: possible implications of neuronal mechanisms in the development of sciatic scoliosis
    J Hirayama
    Physiology, School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 26:602-9. 2001
    ..The effects of electrical stimulation of the sciatic nerve on background electromyographic and static stretch reflex activity of the trunk muscles were studied...
  82. ncbi [A case of anti-Hu antibody- and anti-GluR epsilon2 antibody-positive paraneoplastic neurological syndrome presenting with limbic encephalitis and peripheral neuropathy]
    Shoko Samejima
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 50:467-72. 2010
    ..The patient had severe distal dominant weakness and atrophy in the muscles of all four limbs. Muscle tonus was decreased and hyporeflexia was noted in the four extremities. Plantar response was extensor...
  83. ncbi [Case of DYT1 dystonia (early-onset torsion dystonia) showing long-term focal dystonia in the arm]
    Masaharu Hayashi
    Segawa Neurological Clinic for Children, Tokyo
    No To Hattatsu 40:483-6. 2008
    ..At 11 years of age she was introduced to our clinic. Increased muscle tonus and dystonic discharges seen on surface electromyogram in the right arm and the sternocleidomastoid muscle led ..
  84. ncbi A therapeutic splint for hypertonic flexed elbow in upper motor neuron diseased patients
    O Keren
    Department of Brain Injury Rehabilitation, Loewenstein Rehabilitation Hospital, Ra anana, Israel
    Prosthet Orthot Int 27:63-8. 2003
    Change in muscle tonus is characteristic of upper motor neuron disease. Upper limb hypertonus is mostly experienced in the flexor muscles group, causing abnormal fixed flexion of the elbow...
  85. doi Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation
    Patrícia Angeli
    Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Lung Cell Mol Physiol 294:L1197-205. 2008
    ..Although nitric oxide mediates smooth muscle tonus control in airways, its effects on lung tissue responsiveness have not been investigated previously...
  86. ncbi The 5' region of the human thromboxane A(2) receptor gene
    T Saffak
    Department of Pediatrics, Faculty of Medicine, Philipps University, Marburg, Germany
    Prostaglandins Leukot Essent Fatty Acids 67:25-31. 2002
    Thromboxane is an important modulator of hemostasis and smooth muscle tonus and signals via G-protein-coupled thromboxane receptor...
  87. ncbi [A case of acute bromvalerylurea intoxication: clinical course and alteration in serum bromvalerylurea concentration]
    Hisanori Kowa
    Department of Neurology, Matsue Red Cross Hospital, Matsue
    No To Shinkei 58:323-8. 2006
    ..Neurologically, she had a state of coma and low muscle tonus. EEG showed the pattern of burst-suppression. The level of her serum chloride was not elevated...
  88. ncbi Postural sway during single and repeated cold exposures
    Tiina M Mäkinen
    Centre for Arctic Medicine, Thule Institute, University of Oulu, P O Box 5000, FIN 90014 University of Oulu, Oulu, Finland
    Aviat Space Environ Med 76:947-53. 2005
    ..Tissue cooling changes sensory and neuromuscular functions that are also involved in postural control. The purpose of the study was to determine how acute and repeated exposures to cold affect whole body postural control...
  89. ncbi Evaluation of varicocele frequency of patients with spinal cord injury by color Doppler ultrasonography: a new etiological factor for varicocele?
    Alparslan Unsal
    Adnan Menderes University, Faculty of Medicine, Department of Radiology, Aydin, Turkey
    Eur J Radiol 57:154-7. 2006
    ..To evaluate the varicocele frequency of patients with spinal cord injury by color Doppler ultrasonography...
  90. doi Abdominal muscle function in ventilation and locomotion in new world opossums and basal eutherians: Breathing and running with and without epipubic bones
    Stephen M Reilly
    Department of Biological Sciences, Ohio Center for Ecology and Evolutionary Studies, Ohio University, Athens, Ohio 45701, USA
    J Morphol 270:1014-28. 2009
    ..These new data reveal 1) that continuous abdominal muscle tonus during resting ventilation and a 1:1 breath to step cycle during locomotion appear to be the basal condition ..
  91. ncbi [The origin of homoiothermy--unsolved problem]
    V P Dol'nik
    Zoological Institute, Russian Academy of Sciences, Universitetskaya nab 1, 199034 St Petersburg
    Zh Obshch Biol 64:451-62. 2003
    ..The base of chemical thermoregulation in birds and mammals is a thermoregulatory muscle tonus which remains unknown...
  92. ncbi [Role of an interdisciplinary approach in the healing of long bone fractures in patients with osteogenesis imperfecta]
    M Kokavec
    Detská ortopedická klinika LFUK a DFNsP, Bratislava, Slovenska republika
    Acta Chir Orthop Traumatol Cech 75:185-9. 2008
    ..The aim of the study was to analyze a group of patients who had undergone multilevel osteotomy of long bones and medication therapy for osteogenesis imperfecta (OI)...
  93. ncbi Effects of stress and neuropeptides on airway responses in ovalbumin-sensitized rats
    Carlos P Portela
    Applied Pharmacology and Toxicology Laboratory, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Neuroimmunomodulation 14:105-11. 2007
    ..The aim of this study was to investigate the influence of stress and neuropeptides on airway responses in ovalbumin (OVA)-sensitized rats...
  94. ncbi [Chronological change of EEG findings in a case of pyridoxine dependency seizures]
    R Koga
    Department of Pediatric Neurology, Osaka Medical Center
    No To Hattatsu 22:501-6. 1990
    ..Pyridoxal phosphate (50 mg) was given intravenously, resulting in suppression of convulsions. However, muscle tonus was severely depressed...
  95. doi The effects of osteopathic treatment on constipation in children with cerebral palsy: a pilot study
    Tulay Tarsuslu
    University of Abant Izzet Baysal, KD School of Physical Therapy and Rehabilitation, Bolu, Turkey
    J Manipulative Physiol Ther 32:648-53. 2009
    ..This pilot study was designed to investigate the effectiveness of osteopathic treatment in children with cerebral palsy and chronic constipation...
  96. doi Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independently
    Benedicte Schepens
    Unité de Physiologie et Biomécanique de la Locomotion, Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    J Neurophysiol 100:2235-53. 2008
    ..followed by an extension in the reaching limb while maintaining postural support by increasing extensor muscle tonus in the supporting limbs...
  97. ncbi Effect of nitrous oxide on dental patients with cerebral palsy -- using an electromyogram (EMG) from orofacial muscles as an index
    M Yoshida
    Department of Pediatric Dentistry, Nihon University, School of Dentistry, Tokyo, Japan
    J Oral Rehabil 30:324-33. 2003
    The efficacy of nitrous oxide (N2O) inhalation on the elevated orofacial muscle tonus during dental treatment in patients with cerebral palsy (CP) was studied by measuring the mean frequency of electromyographic (EMG) discharge, blood ..
  98. doi Consequences of sleep deprivation
    Jolanta Orzeł-Gryglewska
    Department of Animal Physiology, University of Gdansk, Gdansk, Poland
    Int J Occup Med Environ Health 23:95-114. 2010
    ..Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher...
  99. ncbi Dystonic posturing associated with putaminal hyperperfusion depicted on subtraction SPECT
    Masahiro Mizobuchi
    Department of Neurology, Nakamura Memorial Hospital, Sapporo, Japan
    Epilepsia 45:948-53. 2004
    ..We evaluated the ictal hyperperfusional areas in patients with DP by using ictal-interictal subtraction single-photon emission computed tomography (SPECT)...
  100. ncbi Ontogenesis of morphine-induced behavior in the cat
    J Wesley Burgess
    Department of Psychiatry and Biobehavioral Sciences, Mental Retardation Research Center and Brain Research Institute, The D Geffen, School of Medicine, University of California, Los Angeles, CA 90024 1759, USA
    Brain Res 1134:53-61. 2007
    ..e., kittens, away from the litter, laid sprawled as if with no muscle tonus; Nursing was suppressed and Vocalization was distressed...
  101. ncbi Opisthotonus and intrathecal treatment with baclofen (ITB) in children
    Berten Ceulemans
    Rehabilitation and Epilepsy Centre for Children and Youth, Reebergenlaan 4, B 2242 Pulderbos, Belgium
    Eur J Pediatr 167:641-5. 2008
    ..Results show that in addition to an expected decrease in muscle tonus, there was also a clear improvement in patient comfort and nursing...

Research Grants143 found, 100 shown here

  1. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2007
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  2. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 1993
    ..It is envisaged that the proposed studies provide important information on the physiology and pharmacology of the IAS leading to a better understanding of the pathophysiology and in turn the treatment, of anorectal disorders...
  3. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPINCHTER
    Satish Rattan; Fiscal Year: 1992
    ..The proposed studies should provide important information on the physiology and pharmacology of the IAS which may be useful in the understanding of pathophysiology, the effects of various drugs and the treatment of anorectal disorders...
  4. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2001
    ..The proposed studies should provide important information leading to a better understanding of the pathophysiology and the treatment of anorectal disorders. ..
  5. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2010
    ..This information will have significant implications in the pathophysiology and therapeutic potentials of the IAS dysfunction. ..
  6. NEUROHUMORAL CONTROL OF INTERNAL ANAL SPHINCTER
    Satish Rattan; Fiscal Year: 2005
    ..Information produced by these studies will permit an understanding of the pathophysiology that underlies disorders of the LAS, and provide a rationale for development of therapies to treat disorders of the IAS. ..
  7. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2002
    ..By examining the fundamental effects of gas embolism bubbles, the proposed experiments will direct us to new clinical strategies for treatment or prevention of gas embolism. ..
  8. Activation of Clotting & cell adhesion : gas embolism
    David Eckmann; Fiscal Year: 2005
    ..abstract_text> ..
  9. Targeted microcarrier design and optimization
    David Eckmann; Fiscal Year: 2009
    ..This work to characterize quantitatively and predict computationally the binding mechanics and dynamics for nanocarrier binding to endothelial cells will lead to improvements in therapeutics for many diseases. ..
  10. Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2005
    ..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
  11. Maternal Hypoxia and Programming of Fetal Heart
    Lubo Zhang; Fiscal Year: 2010
    ....
  12. Steroid Hormones and Uterine Vascular Adaptation to Pregnancy
    Lubo Zhang; Fiscal Year: 2010
    ..In addition, these studies will provide very useful information in understanding fetal origins of cardiovascular disease, which is one of the most provocative recent findings in modern medicine. ..
  13. Cocaine and Apoptosis in the Developing Heart
    Lubo Zhang; Fiscal Year: 2004
    ..Such an understanding has obvious clinical implications because the increasing information has pointed to an important role of apoptosis in cardiovascular diseases. ..
  14. Maternal Hypoxia and Programming of Fetal Heart
    Lubo Zhang; Fiscal Year: 2007
    ....
  15. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  16. Ventral Mesopontine Junction and Motor Activity
    Yuan Yang Lai; Fiscal Year: 2006
    ..This proposed work is of critical importance for the understanding of RLS/PLMD, RBD and other motor pathologies of sleep and for the design of therapeutic strategies to reverse these disorders. ..
  17. Targeted microcarrier design and optimization
    David M Eckmann; Fiscal Year: 2010
    ..This work to characterize quantitatively and predict computationally the binding mechanics and dynamics for nanocarrier binding to endothelial cells will lead to improvements in therapeutics for many diseases. ..
  18. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David M Eckmann; Fiscal Year: 2010
    ..The development of biomimetic surface coatings is a powerful method to increase medical device biocompatibility. ..
  19. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2007
    ....
  20. Prenatal Cocaine Exposure and Cardiac Programming
    Lubo Zhang; Fiscal Year: 2009
    ..abstract_text> ..
  21. INTERFACIAL MECHANICS IN INTRAVASCULAR GAS EMBOLISM
    David Eckmann; Fiscal Year: 2006
    ..The only clinical alternative is hyperbaric therapy, which requires patient transport to a chamber for postembolism treatment, and is therefore generally used only in catastrophic cases. ..
  22. UTERINE VASCULAR ADAPTATION TO LONG TERM HYPOXEMIA
    Lubo Zhang; Fiscal Year: 2001
    ....
  23. Vascular Function after Exposure of Humans to Hypoxia
    James Weiss; Fiscal Year: 2007
    ..We anticipate that these studies will significantly enhance our understanding of how intermittent hypoxia and obstructive sleep apnea influence vascular tone and function. ..
  24. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  25. Airway Hyper-responsiveness: from molecule to organ
    Anne Marie Lauzon; Fiscal Year: 2007
    ..With this approach, the key events in AHR can be identified and targeted for therapeutic intervention. ..
  26. INFLAMMATION AND SIGNAL TRANSDUCTION IN ESOPHAGITIS
    Piero Biancani; Fiscal Year: 2009
    ..Understanding the mechanisms responsible for overproduction of H2O2 may help in devising novel therapeutic approaches focused on restoring normal esophageal and LES function that are not always improved by acid suppression therapy. ..
  27. SPATIAL AND TEMPORAL CONTROL OF TARGETED LIMB MOVEMENTS
    Paul Cordo; Fiscal Year: 2006
    ..abstract_text> ..
  28. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  29. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    Satish Rao; Fiscal Year: 2009
    ..These studies aim to define the mechanisms of, and evaluate new therapies for dyssynergia, rectal hyposensitivity and rectal hypersensitivity, and could significantly impact constipation treatments. ..
  30. Myocardial Stiffness in Aging Associated Diastolic Heart Failure
    Kenneth Campbell; Fiscal Year: 2007
    ..The experimental results will provide new information about the underlying causes of DHF and should help scientists develop better treatments for diastolic dysfunction in elderly populations. ..
  31. EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELS
    William Campbell; Fiscal Year: 2007
    ..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
  32. Myocardial Stiffness in Diastolic Heart Failure
    Kenneth Campbell; Fiscal Year: 2009
    ..The experimental results should help scientists to develop better treatments for the disease in overweight and elderly patients. ..
  33. Self-administration of abused inhalants in mice
    Scott Bowen; Fiscal Year: 2004
    ....
  34. ANGER, SYMPTOM SPECIFIC REACTIVITY AND CHRONIC PAIN
    John Burns; Fiscal Year: 2002
    ..Documenting a link between anger and LP reactivity will give empirical justification for targeting problematic anger among CLPB patients, and will provide principles on which to found new intervention strategies. ..
  35. TRAINING PROGRAM ON THE BIODEMOGRAPHY OF AGING
    STUART OLSHANSKY; Fiscal Year: 2002
    ..In addition, the PI will pursue additional funds through grants to engage in the research that follows from hypotheses that he and colleagues have already formulated and tested in the newly emerging field of biodemography. ..