Genomes and Genes
Summary: The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)
Publications234 found, 100 shown here
- An investigation into the agreement between clinical, biomechanical and neurophysiological measures of spasticityShweta Malhotra
Research Institute for Life Course Studies, University of Keele, Keele, UK
Clin Rehabil 22:1105-15. 2008..To quantify agreement between three clinically usable methods of measuring spasticity...
- Active medullary control of atonia in week-old ratsK A Karlsson
Program in Behavioral and Cognitive Neuroscience, Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
Neuroscience 130:275-83. 2005..All together, these findings demonstrate that muscle atonia is actively regulated very early in ontogeny...
- Laryngeal manual therapy: a preliminary study to examine its treatment effects in the management of muscle tension dysphoniaL Mathieson
The Ear Institute, University College London, London, United Kingdom
J Voice 23:353-66. 2009..This pilot study showed positive evidence for LMT as a method of therapy in the treatment of hyperfunctional voice disorders. Its effects were shown to be measurable with both acoustical analysis and the VTD scale...
- Hypothalamic contribution to sleep-wake cycle developmentK A Karlsson
Program in Behavioral and Cognitive Neuroscience, Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
Neuroscience 123:575-82. 2004..This circuit may represent a basic building block with which other sleep components become integrated during ontogeny...
- KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscleShreena Joshi
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Pharmacol Exp Ther 329:368-76. 2009..The pulmonary vasoconstrictor effect of KCNQ blockers is a potentially serious side effect, but the pulmonary vasodilator effect of the openers may be useful in the treatment of pulmonary hypertension...
- Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledgeEvelyne Van Houtte
Department of Otolaryngology and Head and Neck Surgery, University Hospital Ghent, Belgium
J Voice 25:202-7. 2011..Recent knowledge introduced MTD as a bridge between functional and organic disorders. This review addresses the causal and contributing factors of MTD and evaluates the different treatment options...
- An examination of surface EMG for the assessment of muscle tension dysphoniaEvelyne Van Houtte
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium
J Voice 27:177-86. 2013..sEMG was examined as a diagnostic tool to differentiate between patients with MTD and controls...
- Position of the hyoid and larynx in people with muscle tension dysphoniaSoren Y Lowell
Department of Communication Sciences and Disorders, Syracuse University, Syracuse, New York 13210, USA
Laryngoscope 122:370-7. 2012....
- [The use of fibrolaryngoscopy in muscle tension dysphonia in telemarketers]Oscar A Paoletti
Servicio de Otorrinolaringologia, Sanatorio Allende, Córdoba Capital, Provincia de Cordoba, Argentina
Acta Otorrinolaringol Esp 63:200-5. 2012..This report aims to compare the laryngeal features in telemarketer patients with MTD versus non-dysphonic control subjects...
- The effects of endogenous and exogenous nitric oxide on gut motility in zebrafish Danio rerio embryos and larvaeAnna Holmberg
Department of Zoophysiology, Goteborg University, Box 463, SE 405 30 Goteborg, Sweden
J Exp Biol 209:2472-9. 2006..p.f., and at 1 day later in the proximal intestine. In conclusion, the present study suggests that a nitrergic inhibitory tonus develops shortly before or at the time for onset of exogenous feeding...
- Tonic stretch reflex threshold as a measure of spasticity: implications for clinical practiceAndra Calota
School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada
Top Stroke Rehabil 16:177-88. 2009..We introduce a portable device to measure spasticity, based on the measurement of the tonic stretch reflex threshold, which is more closely related to Lance's definition...
- Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veinsM Back
Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, 177 77 Stockholm, Sweden
Acta Physiol Scand 174:9-15. 2002....
- Integrin-linked kinase regulates N-WASp-mediated actin polymerization and tension development in tracheal smooth muscleWenwu Zhang
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
J Biol Chem 282:34568-80. 2007..We conclude that the recruitment of the ILK.PINCH.alpha-parvin complex to membrane adhesion complexes is required to initiate cytoskeletal processes required for tension development in smooth muscle...
- [Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension]G H H Müller-Schwefe
Regionales Schmerz und Palliativzentrum DGS, Goppingen
MMW Fortschr Med 149:153-61. 2008..Thus, analgesics with muscle tone decreasing effects that apparently normalize increased muscle tonus through specific modes of action without disturbing normal muscular movement are an important therapeutic ..
- Importance of vagal input in maintaining gastric tone in the dogF Azpiroz
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905
J Physiol 384:511-24. 1987..6. We conclude that gastric tone during fasting is maintained by a cholinergic input, which is vagally mediated at both the cervical and the supradiaphragmatic levels...
- Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchiJ L Ellis
Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224
Am J Respir Crit Care Med 149:118-22. 1994..The results suggest that this tone is due to the continual production and release of histamine and cysteinyl-leukotrienes...
- PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffnessCarlos Hidalgo
Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA
Circ Res 105:631-8, 17 p following 638. 2009..Myocardial sarcomeres also contain a third myofilament, titin, and it is unknown whether titin can be phosphorylated by PKC and whether it affects passive tension...
- The treatment of muscle tension dysphonia: a comparison of two treatment techniques by means of an objective multiparameter approachKristiane M Van Lierde
Department of Otorhinolaryngology, Head and Neck Surgery and Speech and Language, University Hospital Gent, Belgium
J Voice 24:294-301. 2010..Further research into this topic could focus on electromyography (EMG) recordings in relation to vocal improvements with larger sample of subjects...
- Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cellsTakashi Akata
Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
J Anesth 21:232-42. 2007....
- Comparison of the tension responses to ramp shortening and lengthening in intact mammalian muscle fibres: crossbridge and non-crossbridge contributionsH Roots
Muscle Contraction Group, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Muscle Res Cell Motil 28:123-39. 2007....
- Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosomeJohn S Lyssand
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 283:18792-800. 2008..Our findings demonstrate that syntrophin and utrophin associate with alpha(1D)-ARs to create a functional signalosome, which is essential for alpha(1D)-AR regulation of vascular tone and blood pressure...
- A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in diseaseRoy Moncayo
WOMED, Karl Kapferer Strasse 5, A 6020 Innsbruck, Austria
BMC Musculoskelet Disord 8:17. 2007..The aim of this study was to investigate this postulate by a musculoskeletal approach together with biochemical parameters...
- Spasticity, an impairment that is poorly defined and poorly measuredS Malhotra
School of Health and Rehabilitation and Research Institute for Life Course Studies, University of Keele, UK
Clin Rehabil 23:651-8. 2009..The congruence between the definitions of spasticity and the corresponding methods of measurement were also explored...
- The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant ratsKarl A E Karlsson
Department of Psychology, University of Iowa, Iowa City 52242, USA
Behav Neurosci 116:912-7. 2002..Thus, MT during infancy occurs against a backdrop of muscle atonia, a result that is consistent with the view that AS is a developmental precursor of REM sleep...
- Cessation of activity in red nucleus neurons during stimulation of the medial medulla in decerebrate ratsBoris Y Mileykovskiy
Veterans Administration, Greater Los Angeles Health System, Sepulveda, California, USA
J Physiol 545:997-1006. 2002..These two mechanisms acting synergistically may cause generalized motor inhibition during REM sleep and cataplexy...
- Static magnetic fields alter arteriolar tone in vivoCassandra Morris
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
Bioelectromagnetics 26:1-9. 2005....
- Change of stretch reflex threshold in spasticity: effect of botulinum toxin injectionsG Stampacchia
Dipartimento di Neuroscienze, Neuroriabilitazione, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Arch Ital Biol 142:265-73. 2004..This effect explains how Botulinum toxin increases the stretch reflex threshold in spastic muscles...
- Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscleEdmund Jooste
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Anesthesiology 102:117-24. 2005..The authors questioned whether rapacuronium preferentially antagonized M2 versus M3 muscarinic receptors in intact airway...
- Modulatory effect of repetitive peripheral magnetic stimulation on skeletal muscle tone in healthy subjects: stabilization of the elbow jointAlbrecht Struppler
Sensorimotor Integration Research Group, Psychiatrische Klinik 7 0, Klinikum rechts der Isar der TUM, Ismaningerstr 22, 81675 Munchen, Germany
Exp Brain Res 157:59-66. 2004..Therefore RPMS is involved in sensorimotor integration and may modulate the motor program at the cortical level...
- Endothelium-dependent blunting of myogenic responsiveness after chronic hypoxiaScott Earley
Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131 5218, USA
Am J Physiol Heart Circ Physiol 283:H2202-9. 2002..We conclude that blunted myogenic reactivity after chronic hypoxia results from a non-NO, endothelium-dependent VSM cell hyperpolarizing influence...
- 17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilationJose A Ospina
Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
Am J Physiol Heart Circ Physiol 285:H241-50. 2003..These effects of estrogen may contribute to the heightened thromboresistance and enhanced cerebral blood flow documented in pre-versus postmenopausal women...
- Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulationSatish Rattan
Division of Gastroenterology and Hepatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Am J Physiol Gastrointest Liver Physiol 287:G605-11. 2004..The advent of CORM-1 with potent effects in the IAS has significant implications in anorectal motility disorders with regard to pathophysiology and therapeutic potentials...
- Adaptation of conduit artery vascular smooth muscle tone to induced hypertensionP Fridez
Laboratory of Hemodynamics and Cardiovascular Technology, Swiss Federal Institute of Technology, Lausanne
Ann Biomed Eng 30:905-16. 2002..The VSM tone returns back to normal levels once the slower geometrical and structural remodeling is developed sufficiently to restore the biomechanical environment and function of the arterial wall to control levels...
- Long-term outcomes of individualized biofeedback training based on the underlying dysfunction for patients with imperforate anusYuan Zhengwei
Department of Pediatric Surgery, Second Affiliated Hospital of China Medical University, Shenyang 110004, China
J Pediatr Surg 40:555-61. 2005..The aim of this study was to design an individualized biofeedback program based on the underlying dysfunctions and to assess the short-term and long-term clinical and quality-of-life outcomes for patients with imperforate anus...
- A new model for the immobilization of the rat hind limbE L Coutinho
Unidade de Plasticidade Muscular, Laboratorio de Neurociencias, Departamento de Fisioterapia, Universidade Federal de Sao Carlos, Sao Carlos, SP, Brasil
Braz J Med Biol Res 35:1329-32. 2002..Immobilization was effective in producing chronic muscle disuse in the hind limbs of rats and is an acceptable alternative to the traditional methods of immobilization such as cast or plaster cast...
- Signaling through NO and cGMP-dependent protein kinasesJens Schlossmann
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Germany
Ann Med 35:21-7. 2003..Activation of the NO/cGMP/cGKI pathway induces relaxation of smooth muscle by lowering the cytosolic calcium level and/or by calcium desensitization of the contractile elements...
- Mechanical properties of rat middle cerebral arteries with and without myogenic toneRebecca J Coulson
Mechanical Engineering Department, University of Vermont, Burlington, VT 05405, USA
J Biomech Eng 126:76-81. 2004..Einc-a (10(6) dynes/cm2) increased significantly with pressure (from 15.1 +/- 2.3 at 75 mmHg to 49.4 +/- 12.6 at 125 mmHg, p < 0.001), indicating a greater contribution of SMC activity to vessel wall stiffness at higher pressures...
- ATP concentrations and muscle tension increase linearly with muscle contractionJianhua Li
Division of Cardiology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
J Appl Physiol (1985) 95:577-83. 2003..Thus ATPi is not largely released from sympathetic or motor nerves and does not require an intact afferent reflex pathway. We conclude that ATPi is due to the release of ATP from contracting skeletal muscle cells...
- Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive ratsMahua Ghosh
Department of Pharmacology and the Cardiovascular Risk Factor Reduction Unit, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5
Br J Pharmacol 141:562-73. 2004..NADPH-oxidase-derived O(2)(-) enhanced spontaneous tone by inactivating NO. Endogenous H(2)O(2) appears to mitigate the increase in tone. In addition, a COX component may also contribute to spontaneous tone...
- Myogenic tone and reactivity of the rat ophthalmic arteryYagna P R Jarajapu
Department of Pharmacology and Therapeutics, Vascular Biology and Cell Physiology Group, College of Medicine, University of Florida, Gainesville, Florida 32610 0267, USA
Invest Ophthalmol Vis Sci 45:253-9. 2004..To study and quantify myogenic behavior and reactivity of the rat ophthalmic artery to pressure and different vasoactive substances in vitro...
- Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cellsRowland W Rees
Wolfson Institute for Biomedical Research, University College London, United Kingdom
J Urol 170:2517-22. 2003..Therefore, we investigated the effect of Y-27632 on prostatic smooth muscle proliferation and tone...
- Effect of caffeine on response of rabbit isolated corpus cavernosum to high K+ solution, noradrenaline and transmural electrical stimulationAdebowale Adebiyi
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
Clin Exp Pharmacol Physiol 31:82-5. 2004..4. The results of the present study suggest that caffeine exhibits relaxant activity on rabbit cavernosal smooth muscle and the mechanism of this activity possibly involves inhibition of Ca2+ signalling...
- Hypotensive effect of butein via the inhibition of angiotensin converting enzymeDae Gill Kang
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
Biol Pharm Bull 26:1345-7. 2003..These results suggest that butein has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme...
- Role of PKCalpha and PKCiota in phenylephrine-induced contraction of rat corpora cavernosaS Husain
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
Int J Impot Res 16:325-33. 2004..0 +/- 0.8 microM vs phenylephrine + chelerythrine chloride 5.7 +/- 2.4 microM). Based on these results, we suggest a potential role for PKCalpha and PKCiota in phenylephrine-induced smooth muscle tone of the rat cavernosum...
- Different responsiveness of excitatory and inhibitory enteric motor neurons in the human esophagus to electrical field stimulation and to nicotineAsensio A Gonzalez
Fundació de Gastroenterologia Dr Francisco Vilardell, 08025 Barcelona, Spain
Am J Physiol Gastrointest Liver Physiol 287:G299-306. 2004....
- Differences in hamstring muscle stretching of elite field hockey players and normal subjectsM Jaeger
Department of Orthopaedic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Sportverletz Sportschaden 17:65-70. 2003..To investigate differences in stretching behaviour of hamstring muscles in elite field hockey players and normal subjects...
- Is the mitral valve passive flap theory overstated? An active valve is hypothesizedT H Williams
Department of Anatomy and Cell Biology, University of Iowa, 1 449 Bowen Science Building, Iowa City, IA 52242, USA
Med Hypotheses 62:605-11. 2004....
- Physiology and biochemistry of erectionsGeorge J Christ
Departments of Urology and Physiology and Biophysics, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Endocrine 23:93-100. 2004..This article reviews fundamental aspects of the physiology of erection and summarizes the most recent information available concerning the putative biochemical correlates of these physiologic events...
- Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensingAlan L Peterson
Circulation 107:e198; author reply e198. 2003
- Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesiaRobert C Dutton
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
Anesthesiology 98:1372-7. 2003..General anesthesia may delay the onset of movement in response to noxious stimulation. The authors hypothesized that the production of immobility could involve depression of time-related processes involved in the generation of movement...
- Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscleJurgen W G E VanTeeffelen
The John B Pierce Laboratory and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06519, USA
J Physiol 550:563-74. 2003..Such concerted interaction will promote oxygen extraction when blood flow is restricted to maintain arterial pressure...
- Comparison of U46619-, endothelin-1- or phenylephrine-induced changes in cellular Ca2+ profiles and Ca2+ sensitisation of constriction of pressurised rat resistance arteriesLinda Shaw
Smooth Muscle Physiology Group, Cardiovascular Research, University of Manchester, Manchester
Br J Pharmacol 141:678-88. 2004....
- 5-HT4 receptor enhances the propulsive power of the peristaltic reflex in the rat distal colonMakoto Kadowaki
Department of Physiology II, Nara Medical University, Kashihara, Japan
Auton Neurosci 99:62-5. 2002..0 cm H2O (n = 8, P<0.05) without affecting the resting muscle tone in the distal colon. The present result suggests that stimulation of 5-HT4 receptor enhances the propulsive power to move the luminal contents in the rat distal colon...
- [The role of stimulation parameters of sympathetic nerves in regulation of microvessel tone in the rat stomach]M V Lentsman
I. P. Pavlov Institute of Physiology, Russian Acad. Sci, St. Petersburg, 199034, Nab. Makarova, Russia
Ross Fiziol Zh Im I M Sechenova 87:1402-12. 2001..Thereupon, an efficient control of microvascular tone can be achieved by grouping the pulses into bursts or by an increase of the burst rate or duration...
- [Contractile function of vessel myocytes: dependence on the stretch magnitude]D P Dvoretskii
I P Pavlov Institute of Physiology, Russian Acad Sci, St Petersburg, 199034, Nab Makarova, 6, Russia
Ross Fiziol Zh Im I M Sechenova 87:1318-24. 2001..The findings show that the magnitude of stretch corresponding to the maximal effect depend on the character of responses, on the factor, and on the responses occurrence conditions...
- Dopamine receptors in the subthalamic nucleus are involved in the regulation of muscle tone in the ratKim M Hemsley
Department of Clinical Pharmacology and Centre for Neuroscience, The Flinders University of South Australia, Bedford Park SA 5042, Australia
Neurosci Lett 317:123-6. 2002..These results provide new evidence that dopamine receptors located in the STN play an important role in the regulation of normal muscle tone...
- Changes in muscle tone are regulated by D1 and D2 dopamine receptors in the ventral striatum and D1 receptors in the substantia nigraK M Hemsley
Department of Clinical Pharmacology and Centre for Neuroscience, Flinders University of South Australia, Bedford Park, Australia
Neuropsychopharmacology 25:514-26. 2001..Overall the results support roles for dopamine D1 and D2 receptors in the ventral striatum, and D1 receptors in the substantia nigra, in the regulation of muscle tone...
- Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channelsPedro Marcos G Soares
Instituto Superior de Ciências Biomédicas, ISCB CCS, Universidade Estadual do Ceara, Av Paranjana 1700, 60740 000, Fortaleza CE, Brazil
Life Sci 81:1085-93. 2007....
- [Modern concept of peripheral erectile mechanisms]M I Boiko
Institute of Urology and Nephrology, Academy of Medical Sciences of Ukraine, Kiev
Fiziol Zh 47:116-32. 2001..A better understanding of the peripheral pharmacology of erection opens the way to new pathophysiological and therapeutic prospects in the broad context of erectile dysfunction...
- Vasomotor effects of noradrenaline, acetylcholine, histamine, 5-hydroxytryptamine and bradykinin on snake (Trimeresurus flavoviridis) basilar arteriesNarihiro Yoshinaga
Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University, 1 21 24 Korimoto, Kagoshima 890 0065, Japan
Comp Biochem Physiol C Toxicol Pharmacol 146:478-83. 2007..Endothelial cells might play an important role in the responsiveness of snake basilar arteries to rattlesnake BK, but they might not be involved in the responsiveness to ACh, BK and in resting vascular tone...
- The effect of creatine supplementation on mass and performance of rat skeletal muscleRobert E Young
Department of Kinesiology, University of Nevada, Las Vegas, Las Vegas, NV 89154, United States
Life Sci 81:710-6. 2007....
- Effects of spermine on the relaxation response of rat detrusor smooth musclesSoon Chul Myung
Department of Urology and Physiology, Chung Ang University, College of Medicine, Dongjak Gu, Huksuk Dong 221, Seoul, South Korea
Eur J Pharmacol 573:196-200. 2007..We concluded that spermine exerts a potent relaxant effect on rat bladder smooth muscle, and this effect appears to be mediated by calcium channel antagonism...
- Inhibitors of gap junctions attenuate myogenic tone in cerebral arteriesGuy Lagaud
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
Am J Physiol Heart Circ Physiol 283:H2177-86. 2002..These data indicate that gap junctions play an important role in the maintenance and modulation of membrane potential and tone in cerebral resistance arteries...
- Nonspecific inhibition of myogenic tone by PD98059, a MEK1 inhibitor, in rat middle cerebral arteriesG J Lagaud
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
Biochem Biophys Res Commun 257:523-7. 1999..However, our results also demonstrate that PD98059 may have nonspecific effects on voltage-sensitive Ca2+ entry in vascular smooth muscle...
- The investigation of putative agents, using an in vitro model, to prevent cavernosal smooth muscle dysfunction during low-flow priapismAsif Muneer
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
BJU Int 102:988-92. 2008....
- Non-adrenergic, non-cholinergic neural activation in guinea-pig bronchi: powerful and frequency-dependent stabilizing effect on toneA Linden
Division of Pulmonary Medicine, Renströmska Hospital, University of Goteborg, Sweden
Br J Pharmacol 109:845-51. 1993..Our findings are consistent with a regulatory role for NANC responses in the control of bronchial smooth-muscle tone...
- Interindividual differences in H reflex modulation during normal walkingErik B Simonsen
Institute of Medical Anatomy, The Panum Institute, University of Copenhagen, Blegdamsvej 3C, 2200 Copenhagen N, Denmark
Exp Brain Res 142:108-15. 2002..Alternatively, in subjects with a suppressed H reflex in the swing phase the knee joint extensors seem to form the primary protection around heel strike...
- Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout miceJohn N Lorenz
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
Am J Physiol Regul Integr Comp Physiol 292:R440-6. 2007..This is mediated, at least in part, through an effect on the endothelium, but direct effects on vascular smooth muscle cannot be ruled out and require further investigation...
- Effects of alkaloids of Himatanthus lancifolius (Muell. Arg.) Woodson, Apocynaceae, on smooth muscle responsivenessYanna D Rattmann
Department of Pharmacology, Biological Sciences Sector, Universidade Federal of Paraná, Curitiba, Brazil
J Ethnopharmacol 100:268-75. 2005....
- Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundusTakayuki Matsumoto
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
J Smooth Muscle Res 41:107-16. 2005..We speculate that a major factor mediating the relaxant action of PDBu in rat stomach fundus smooth muscle is represented by a reduction in Ca2+ influx via an inhibition of Ca2+ channels...
- Activation of the midbrain periaqueductal gray induces airway smooth muscle relaxationMusa A Haxhiu
Department of Physiology and Biophysics, College of Medicine Howard University and Specialized Neuroscience Research Program of Howard University, Washington, DC 20059, USA
J Appl Physiol 93:440-9. 2002..These data indicate, for the first time, that activation of vl PAG dilates the airways by a release of GABA and activation of GABA(A) receptors expressed by AVPNs...
- Kinetics of restoration of arteriolar tone after exerciseThomas J Barstow
J Appl Physiol 99:775. 2005
- Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blockerRichard H Kennedy
Department of Pharmaceutical Sciences and Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas, USA
Clin Exp Pharmacol Physiol 33:340-4. 2006..However, the relatively minor antagonistic action of SPT on the inotropic effect of homocysteine suggests that additional endothelium-derived mediators underlie its effects on contractility...
- Neuropeptide Y in rat detrusor and its effect on nerve-mediated and acetylcholine-evoked contractionsM M Iravani
Department of Pharmacological Sciences, Medical School, Newcastle upon Tyne
Br J Pharmacol 113:95-102. 1994..Keywords: Detrusor muscle; urinary bladder; neuropeptide Y; cholinergic neurotransmission; non-cholinergic neurotransmission;nifedipine..
- Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medullaBoris Y Mileykovskiy
Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg 194223, Russia
J Neurophysiol 87:2480-9. 2002..Loss of OX function may, therefore, disturb both muscle tone facilitatory and inhibitory processes at the medullary level...
- Regulation of human penile smooth muscle tone by prostanoid receptorsJavier Angulo
Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
Br J Pharmacol 136:23-30. 2002..TP-receptors mediate contraction in HCCS and HPRA, while the relaxant effects of prostanoids are mediated by EP2- and/or EP4-receptors in HCCS and by EP- and IP-receptors in HPRA...
- Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscleChirag A Patel
Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 1025 Walnut St, Rm 901, Philadelphia, PA 19107, USA
Am J Physiol Gastrointest Liver Physiol 291:G830-7. 2006..We conclude that RhoA/ROK plays a critical role in the basal tone in the IAS by the inhibition of MLC phosphatase via the phosphorylation of MYPT1 and CPI-17...
- Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic ratKatsuo Kamata
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
J Smooth Muscle Res 42:171-87. 2006..These results suggest that in the STZ-induced diabetic perfused kidney, vasorelaxant metabolites derived from AA (probably COX and/or CYP450 metabolites) are increased, and may serve to regulate vascular tone...
- Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunctionM M Lalu
Department of Pharmacology, Cardiovascular Research Group, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
Br J Pharmacol 149:31-42. 2006..This possibility was tested in rat aortic tissue...
- Effect of pH changes on reactivity of rat mesenteric artery segments at different magnitude of stretchV N Yartsev
Laboratory of Circulation, Pavlov Institute of Physiology, nab Makarova 6, St Petersburg, 199034, Russia
Acta Physiol Scand 174:1-7. 2002..In addition, it was shown that acidosis is able to act not only as the commonly known dilator agent, but also as an agent potentiating constriction in case of the high noradrenaline-induced tone...
- [Secretory function of the endothelium as a factor of vascular tone regulation in the norm and in cardiovascular pathology]N A Medvedeva
M. V. Lomonossov State University, 119899, Vorobievy Gory, Moscow, Russia
Ross Fiziol Zh Im I M Sechenova 87:1518-26. 2001..The altered interrelationships between the endothelium-derived vasoactive substances may precede pathological shifts in the cardiovascular system...
- Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscleTakio Kitazawa
Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, 069 8501, Japan
Naunyn Schmiedebergs Arch Pharmacol 377:503-13. 2008..Carbachol (10 nM-100 microM) increased muscle tonus and phasic contractile activity of uterine strips of control mice in a concentration-dependent manner...
- Inhibitory actions of dopamine on Limulus visceral muscle involve a cyclic AMP-dependent mechanismJ R Groome
Zoology Department, University of New Hampshire, Durham 03824
J Comp Physiol A 170:787-95. 1992..2. Catecholamines decreased muscle tonus and inhibited spontaneous contractions of the Limulus midgut...
- [Cervicogenic proprioceptive vertigo: etiopathogenesis, clinical manifestations, diagnosis and therapy with special emphasis on manual therapy]Vjekoslav Grgic
Lijec Vjesn 128:288-95. 2006..Hyperactivity of craniocervical mechanoreceptors also causes disturbances in reflex regulation of postural muscle tonus manifesting as "general instability"...
- Arousal systemsBarbara E Jones
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
Front Biosci 8:s438-51. 2003..low frequency rhythmic theta activity, and through descending projections to the spinal cord, they stimulate muscle tonus along with sensory-motor responsiveness and activity...
- The effect of biofeedback physical therapy in men with Chronic Pelvic Pain Syndrome Type IIIErik B Cornel
Department of Urology, Ziekenhuis Groep Twente location SMT, P O Box 546, 7550 AM Hengelo, The Netherlands
Eur Urol 47:607-11. 2005..The objective of this study was to evaluate the effect of biofeedback physical therapy on the symptoms of men with CPPS...
- Effects of electrical stimulation of the sciatic nerve on background electromyography and static stretch reflex activity of the trunk muscles in rats: possible implications of neuronal mechanisms in the development of sciatic scoliosisJ Hirayama
Physiology, School of Medicine, Chiba University, Chiba, Japan
Spine (Phila Pa 1976) 26:602-9. 2001..The effects of electrical stimulation of the sciatic nerve on background electromyographic and static stretch reflex activity of the trunk muscles were studied...
- [A case of anti-Hu antibody- and anti-GluR epsilon2 antibody-positive paraneoplastic neurological syndrome presenting with limbic encephalitis and peripheral neuropathy]Shoko Samejima
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
Rinsho Shinkeigaku 50:467-72. 2010..The patient had severe distal dominant weakness and atrophy in the muscles of all four limbs. Muscle tonus was decreased and hyporeflexia was noted in the four extremities. Plantar response was extensor...
- [Case of DYT1 dystonia (early-onset torsion dystonia) showing long-term focal dystonia in the arm]Masaharu Hayashi
Segawa Neurological Clinic for Children, Tokyo
No To Hattatsu 40:483-6. 2008..At 11 years of age she was introduced to our clinic. Increased muscle tonus and dystonic discharges seen on surface electromyogram in the right arm and the sternocleidomastoid muscle led ..
- A therapeutic splint for hypertonic flexed elbow in upper motor neuron diseased patientsO Keren
Department of Brain Injury Rehabilitation, Loewenstein Rehabilitation Hospital, Ra anana, Israel
Prosthet Orthot Int 27:63-8. 2003Change in muscle tonus is characteristic of upper motor neuron disease. Upper limb hypertonus is mostly experienced in the flexor muscles group, causing abnormal fixed flexion of the elbow...
- Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammationPatrícia Angeli
Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Am J Physiol Lung Cell Mol Physiol 294:L1197-205. 2008..Although nitric oxide mediates smooth muscle tonus control in airways, its effects on lung tissue responsiveness have not been investigated previously...
- [A case of acute bromvalerylurea intoxication: clinical course and alteration in serum bromvalerylurea concentration]Hisanori Kowa
Department of Neurology, Matsue Red Cross Hospital, Matsue
No To Shinkei 58:323-8. 2006..Neurologically, she had a state of coma and low muscle tonus. EEG showed the pattern of burst-suppression. The level of her serum chloride was not elevated...
- Postural sway during single and repeated cold exposuresTiina M Mäkinen
Centre for Arctic Medicine, Thule Institute, University of Oulu, P O Box 5000, FIN 90014 University of Oulu, Oulu, Finland
Aviat Space Environ Med 76:947-53. 2005..Tissue cooling changes sensory and neuromuscular functions that are also involved in postural control. The purpose of the study was to determine how acute and repeated exposures to cold affect whole body postural control...
- Abdominal muscle function in ventilation and locomotion in new world opossums and basal eutherians: Breathing and running with and without epipubic bonesStephen M Reilly
Department of Biological Sciences, Ohio Center for Ecology and Evolutionary Studies, Ohio University, Athens, Ohio 45701, USA
J Morphol 270:1014-28. 2009..These new data reveal 1) that continuous abdominal muscle tonus during resting ventilation and a 1:1 breath to step cycle during locomotion appear to be the basal condition ..
- Evaluation of varicocele frequency of patients with spinal cord injury by color Doppler ultrasonography: a new etiological factor for varicocele?Alparslan Unsal
Adnan Menderes University, Faculty of Medicine, Department of Radiology, Aydin, Turkey
Eur J Radiol 57:154-7. 2006..To evaluate the varicocele frequency of patients with spinal cord injury by color Doppler ultrasonography...
- [The origin of homoiothermy--unsolved problem]V P Dol'nik
Zoological Institute, Russian Academy of Sciences, Universitetskaya nab 1, 199034 St Petersburg
Zh Obshch Biol 64:451-62. 2003..The base of chemical thermoregulation in birds and mammals is a thermoregulatory muscle tonus which remains unknown...
- Effects of stress and neuropeptides on airway responses in ovalbumin-sensitized ratsCarlos P Portela
Applied Pharmacology and Toxicology Laboratory, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
Neuroimmunomodulation 14:105-11. 2007..The aim of this study was to investigate the influence of stress and neuropeptides on airway responses in ovalbumin (OVA)-sensitized rats...
- [Role of an interdisciplinary approach in the healing of long bone fractures in patients with osteogenesis imperfecta]M Kokavec
Detská ortopedická klinika LFUK a DFNsP, Bratislava, Slovenska republika
Acta Chir Orthop Traumatol Cech 75:185-9. 2008..The aim of the study was to analyze a group of patients who had undergone multilevel osteotomy of long bones and medication therapy for osteogenesis imperfecta (OI)...
- [Chronological change of EEG findings in a case of pyridoxine dependency seizures]R Koga
Department of Pediatric Neurology, Osaka Medical Center
No To Hattatsu 22:501-6. 1990..Pyridoxal phosphate (50 mg) was given intravenously, resulting in suppression of convulsions. However, muscle tonus was severely depressed...
- The effects of osteopathic treatment on constipation in children with cerebral palsy: a pilot studyTulay Tarsuslu
University of Abant Izzet Baysal, KD School of Physical Therapy and Rehabilitation, Bolu, Turkey
J Manipulative Physiol Ther 32:648-53. 2009..This pilot study was designed to investigate the effectiveness of osteopathic treatment in children with cerebral palsy and chronic constipation...
- Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independentlyBenedicte Schepens
Unité de Physiologie et Biomécanique de la Locomotion, Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Louvain la Neuve, Belgium
J Neurophysiol 100:2235-53. 2008..followed by an extension in the reaching limb while maintaining postural support by increasing extensor muscle tonus in the supporting limbs...
- Ventral Mesopontine Junction and Motor ActivityYuan Yang Lai; Fiscal Year: 2006..This proposed work is of critical importance for the understanding of RLS/PLMD, RBD and other motor pathologies of sleep and for the design of therapeutic strategies to reverse these disorders. ..
- Activation of clotting & cell adhesion: gas embolismDavid M Eckmann; Fiscal Year: 2010..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
- SHEAR STRESS INDUCED RELEASE OF ENDOTHELIAL NITRIC OXIDEMichael Davis; Fiscal Year: 2001....
- TRAINING WORKSHOP IN BASIC SLEEP RESEARCHMichael Chase; Fiscal Year: 2003..In addition, the Workshops will include special sections dealing with ethics and grantsmanship; they will also provide a wide range of instruction on basic animal research and basic human research. ..
- STATE DEPENDENT CONTROL OF MOTORNEURON ACTIVITYMichael Chase; Fiscal Year: 2004..abstract_text> ..
- SLEEP MECHANISMS IN THE AGED CATMichael Chase; Fiscal Year: 2003....
- Retrovial Infections of the Nervous System in PeruJOSEPH RAYMOND ZUNT; Fiscal Year: 2010..In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant. ..
- Ex Vivo Delineation of Mechanisms of Cerebral VasospasmJAY HUMPHREY; Fiscal Year: 2008..In summary, we submit that this project will reveal new insight into mechanisms. ..
- Uterine Vascular Adaptation to PregnancyLubo Zhang; Fiscal Year: 2005..Such an understanding has obvious clinical implications because the maladaptation of uterine circulation to pregnancy is associated with fetal developmental abnormalities and maternal cardiovascular disorders. ..
- BIOPHYSICAL PRINCIPLES OF PERISTALTIC PHENOMENAPiero Biancani; Fiscal Year: 2006..These data will help in understanding contractile pathways in the normal esophagus and LES, and may provide a basis for better understanding of changes associated with some esophageal motor disorders. ..
- Time Domains of Sympathetic Activity following HypoxiaJames Weiss; Fiscal Year: 2006..abstract_text> ..
- Cartoid Mediators of Sympathoexcitation in Sleep ApneaJames Weiss; Fiscal Year: 2006..These studies will enhance our understanding of how sleep apnea contributes to hemodynamic and metabolic abnormalities. ..
- Nitric Oxide Regulation of Adrenal SteroidogenesisWilliam Campbell; Fiscal Year: 2004..4) We will determine the role of endothelial NO in regulating steroidogenesis and adrenal blood flow in the in situ perfused adrenal gland and in vivo in anesthetized rats. ..
- Vascular Function after Exposure of Humans to HypoxiaJames Weiss; Fiscal Year: 2009..We anticipate that these studies will significantly enhance our understanding of how intermittent hypoxia and obstructive sleep apnea influence vascular tone and function. ..
- Repressive Style, suppression and chronic PainJohn Burns; Fiscal Year: 2004..Moreover, findings should provide theoretical principles on which to found new intervention strategies (e.g., "regulating" suppression by engaging in cognitive exercises). ..
- MECHANISM AND FUNCTION OF THE VASCULAR MYOGENIC RESPONSEMichael Davis; Fiscal Year: 2002....
- Regulation of vascular smooth muscle calcium sensitivityPaul H Ratz; Fiscal Year: 2010..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
- CHRONIC CORONARY OCCLUSION, EXERCISE TRAINING AND NOCristine L Heaps; Fiscal Year: 2010....
- SUNDOWN SYNDROME IN A SKILLED NURSING FACILITYDonald Bliwise; Fiscal Year: 2002..These results will provide information on the mechanistic basis for sundowning in aged patients with dementing disorders. ..
- Sleep in CetaceansJerome Siegel; Fiscal Year: 2006..The proposed studies take advantage of a rapidly vanishing opportunity to study cetacean sleep. They will improve our understanding of the physiological and neurochemical substrates of mammalian sleep. ..
- Cocaine and Apoptosis in the Developing HeartLubo Zhang; Fiscal Year: 2004..Such an understanding has obvious clinical implications because the increasing information has pointed to an important role of apoptosis in cardiovascular diseases. ..
- Sleep/Wake Contiuum in Lewy Body DiseaseDonald L Bliwise; Fiscal Year: 2010..The proposed work will also provide important clinical insights into disease correlates and disease course across the broad spectrum of Parkinsonism. ..
- Anger Expression, Endogenous Opioids and Acute PainJohn Burns; Fiscal Year: 2008..unreadable] [unreadable]..
- EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSUREWILLIAM BRYSON CAMPBELL; Fiscal Year: 2010..These studies will test the hypothesis that endogenous LO metabolites are important regulators of vascular tone and blood pressure in mice. ..
- Behavioral Effects of Gestational Inhalant Abuse in RatsScott Bowen; Fiscal Year: 2006..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
- Control of Muscle Tone in nonREM SleepJerome Siegel; Fiscal Year: 2009..Our work will also suggest improved pharmacological treatments for PLMS, sleepwalking and bruxism. ..
- Prenatal Cocaine Exposure and Cardiac ProgrammingLubo Zhang; Fiscal Year: 2009..abstract_text> ..
- Regulation of Arteriolar Tone & K Channels by IntegrinsMichael Davis; Fiscal Year: 2006..In addition, our results will establish a paradigm for understanding how other ion channels in other tissues may be regulated by integrins. ..
- MECHANISMS OF CUTANEOUS ACTIVE VASODILATIONDean Kellogg; Fiscal Year: 2008..In addition, intradermal microdialysis will be combined with measurements of bioavailable NO by NO-selective amperometric electrode to define further how the NO system functions in cutaneous active vasodilation. ..
- Polysomnographic Assessment of Alternative TreatmentDonald Bliwise; Fiscal Year: 2006..abstract_text> ..
- Mechanisms of resistance artery contractionJOSEPH ELLIOTT BRAYDEN; Fiscal Year: 2010..abstract_text> ..
- CNS Sites Mediating Cognition and Mood: Impact of ApneaMichael Chase; Fiscal Year: 2008..These studies will therefore provide a foundation for the development of therapeutic treatments for Obstructive Sleep Apnea, including the neurocognitive and mood disorders that occur as a consequence of this pathology. ..
- NEUROMUSCULAR STRATEGIES FOR HUMAN TONGUE MOVEMENTALAN SOKOLOFF; Fiscal Year: 2007..These studies will provide important information on the neurobiology of the tongue motor system and will provide the first direct tests of the molecular and physiological bases of aging of the human tongue motor system. ..
- Brainstem Regulation of Active Sleep and WakefulnessMichael Chase; Fiscal Year: 2007..that these data will be directly applicable to the development of rational therapies for the treatment of sleep and waking disorders that arise as a result of the pathological functioning of these neuronal mechanisms ..
- Web-based Sleep Research Protocols and StandardsMichael Chase; Fiscal Year: 2004..It will also provide an infrastructure for the development of interactions and linkages between basic and clinical areas of investigation...
- Mechanical Stress and the Heat-Treatment of Soft TissueJAY HUMPHREY; Fiscal Year: 2003..There is a need for a firmer scientific understanding. ..
- FEMALE SEXUAL AROUSAL: CLITORAL AND VAGINAL PHYSIOLOGYAbdulmaged Traish; Fiscal Year: 2003....
- Novel Organ Culture & Theory for Arteriolar RemodelingJAY HUMPHREY; Fiscal Year: 2005..We will collect simultaneous pressure-diameter, cell morphological, and actin cytoskeletal data at multiple times during the remodeling, which in turn will allow us to develop a novel, single theoretical framework. ..
- REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTIONPAUL RATZ; Fiscal Year: 2005..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
- COR HONORS HIGH SCHOOL RESEARCH EDUCATIONJoseph Dunbar; Fiscal Year: 2005..abstract_text> ..
- TREATMENT FOR COMORBID ASTHMA AND PANIC DISORDERPaul Lehrer; Fiscal Year: 2002..The principal outcome measures will be indices of high/low PD end-state functioning and improvement in asthma severity. A number of exploratory measures also will be analyzed. ..
- Biomarkers of Aging in the Bay Area Sleep CohortDonald Bliwise; Fiscal Year: 2005..abstract_text> ..
- Histo-Mechanics & Biology of Remodeling in HypertensionJAY HUMPHREY; Fiscal Year: 2005..Subsequent parallel studies will focus on additional pharmacological agents and gender-related differences. ..
- Physical Activity, Aging and Immune FunctionJeffrey Woods; Fiscal Year: 2005..In addition, the biobehavioral approach inherent in our aims will allow us to determine the complexity of the relationship between exercise and immune function. ..
- Tongue Volume, Function and BiomechanicsZi Jun Liu; Fiscal Year: 2006..Application of this information will allow understanding of normal tongue functional morphology and to evaluate how tongue volume affects function and craniofacial growth. ..
- Neurotransmitter Control of Sleep and WakefulnessMichael Chase; Fiscal Year: 2005..abstract_text> ..
- NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLEChristopher Rembold; Fiscal Year: 2004....
- ANGER, SYMPTOM SPECIFIC REACTIVITY AND CHRONIC PAINJohn Burns; Fiscal Year: 2002..Documenting a link between anger and LP reactivity will give empirical justification for targeting problematic anger among CLPB patients, and will provide principles on which to found new intervention strategies. ..
- TRAINING PROGRAM ON THE BIODEMOGRAPHY OF AGINGSTUART OLSHANSKY; Fiscal Year: 2002..In addition, the PI will pursue additional funds through grants to engage in the research that follows from hypotheses that he and colleagues have already formulated and tested in the newly emerging field of biodemography. ..
- EICOSANOID SYNTHESIS AND FUNCTION IN CORONARY VESSELSWILLIAM BRYSON CAMPBELL; Fiscal Year: 2010..These studies will provide specific pharmacological tools to study the role of EETs as EDHFs and provide new insights into the vascular action of the EETs. ..
- SPATIAL AND TEMPORAL CONTROL OF TARGETED LIMB MOVEMENTSPaul Cordo; Fiscal Year: 2006..abstract_text> ..
- Central Nervous System Infections in PeruJoseph Zunt; Fiscal Year: 2004..The second year will be used to complete and analyze these pilot studies and prepare the R01 application. ..
- DYNAMICS OF MUSCLE FORCE PRODUCTION DURING LOCOMOTIONThomas Roberts; Fiscal Year: 2003....
- Myocardial Stiffness in Aging Associated Diastolic Heart FailureKenneth Campbell; Fiscal Year: 2007..The experimental results will provide new information about the underlying causes of DHF and should help scientists develop better treatments for diastolic dysfunction in elderly populations. [unreadable] [unreadable] [unreadable]..
- Self-administration of abused inhalants in miceScott Bowen; Fiscal Year: 2004....
- COORDINATION OF SITTING UPPaul Cordo; Fiscal Year: 2001..The vertical forces produced on the support surface will be recorded along with segmental kinematics and muscle (EMG) activity. ..
- NEUROLOGIC/IMMUNOLOGIC MANIFESTATION OF HTLV-I INFECTIONJoseph Zunt; Fiscal Year: 2004....
- NONGENOMIC MECHANISMS OF ANDROGENS IN THE VASCULAR WALLJOHN STALLONE; Fiscal Year: 2009..It is well-established that marked sexual dimorphism exists in a variety of human cardiovascular diseases;thus the proposed research is directly relevant to human health and cardiovascular disease. ..