muscle fatigue

Summary

Summary: A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

Top Publications

  1. ncbi Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
  2. ncbi Skeletal muscle fatigue: cellular mechanisms
    D G Allen
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Physiol Rev 88:287-332. 2008
  3. pmc A review of non-invasive techniques to detect and predict localised muscle fatigue
    Mohamed R Al-Mulla
    School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK
    Sensors (Basel) 11:3545-94. 2011
  4. ncbi Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 91:1055-60. 2001
  5. ncbi A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions
    Janet L Taylor
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 104:542-50. 2008
  6. ncbi Repeated-sprint ability - part I: factors contributing to fatigue
    Olivier Girard
    Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar
    Sports Med 41:673-94. 2011
  7. pmc Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better?
    Patrícia de Almeida
    Post Graduate Program in Rehabilitation Sciences, Nove de Julho University UNINOVE, Rua Vergueiro, 235, 01504 001, Sao Paulo, SP, Brazil
    Lasers Med Sci 27:453-8. 2012
  8. pmc Neuromuscular consequences of an extreme mountain ultra-marathon
    Guillaume Y Millet
    Universite de Lyon, F 42023, Saint Etienne, France
    PLoS ONE 6:e17059. 2011
  9. ncbi Nervous system function during exercise in hypoxia
    Markus Amann
    University of Zurich, Institute of Physiology, and ETH Zurich, Exercise Physiology, Zurich, Switzerland
    High Alt Med Biol 10:149-64. 2009
  10. ncbi Distributed low-frequency functional electrical stimulation delays muscle fatigue compared to conventional stimulation
    Nebojsa M Malesevic
    Faculty of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, 11000 Belgrade, Serbia
    Muscle Nerve 42:556-62. 2010

Detail Information

Publications363 found, 100 shown here

  1. ncbi Spinal and supraspinal factors in human muscle fatigue
    S C Gandevia
    Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Randwick, Sydney, Australia
    Physiol Rev 81:1725-89. 2001
    b>Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force...
  2. ncbi Skeletal muscle fatigue: cellular mechanisms
    D G Allen
    School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Physiol Rev 88:287-332. 2008
    Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular ..
  3. pmc A review of non-invasive techniques to detect and predict localised muscle fatigue
    Mohamed R Al-Mulla
    School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK
    Sensors (Basel) 11:3545-94. 2011
    b>Muscle fatigue is an established area of research and various types of muscle fatigue have been investigated in order to fully understand the condition...
  4. ncbi Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 91:1055-60. 2001
    ..In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage...
  5. ncbi A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions
    Janet L Taylor
    Prince of Wales Medical Research Institute, Barker St, Randwick, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 104:542-50. 2008
    ..The best indication that central fatigue is important during submaximal tasks is the disproportionate increase in subjects' perceived effort when maintaining a low target force...
  6. ncbi Repeated-sprint ability - part I: factors contributing to fatigue
    Olivier Girard
    Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar
    Sports Med 41:673-94. 2011
    ..Pending confirmatory research, other factors such as stiffness regulation, hypoglycaemia, muscle damage and hostile environments (e.g. heat, hypoxia) are also likely to compromise fatigue resistance during repeated-sprint protocols...
  7. pmc Red (660 nm) and infrared (830 nm) low-level laser therapy in skeletal muscle fatigue in humans: what is better?
    Patrícia de Almeida
    Post Graduate Program in Rehabilitation Sciences, Nove de Julho University UNINOVE, Rua Vergueiro, 235, 01504 001, Sao Paulo, SP, Brazil
    Lasers Med Sci 27:453-8. 2012
    ..therapy (LLLT) using red, infrared and mixed wavelengths has been shown to delay the development of skeletal muscle fatigue. However, the parameters employed in these studies do not allow a conclusion as to which wavelength range is ..
  8. pmc Neuromuscular consequences of an extreme mountain ultra-marathon
    Guillaume Y Millet
    Universite de Lyon, F 42023, Saint Etienne, France
    PLoS ONE 6:e17059. 2011
    ..It is also concluded that as early as two weeks after such an extreme running exercise, maximal force capacities have returned to baseline...
  9. ncbi Nervous system function during exercise in hypoxia
    Markus Amann
    University of Zurich, Institute of Physiology, and ETH Zurich, Exercise Physiology, Zurich, Switzerland
    High Alt Med Biol 10:149-64. 2009
    ..In moderate hypoxia, muscle afferents appear to play an important role, whereas in severe hypoxia brain oxygenation may play a more important role...
  10. ncbi Distributed low-frequency functional electrical stimulation delays muscle fatigue compared to conventional stimulation
    Nebojsa M Malesevic
    Faculty of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, 11000 Belgrade, Serbia
    Muscle Nerve 42:556-62. 2010
    We present a low-frequency stimulation method via multi-pad electrodes for delaying muscle fatigue. We compared two protocols for muscle activation of the quadriceps in paraplegics...
  11. ncbi Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractions
    Stuart Goodall
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    J Appl Physiol (1985) 109:1842-51. 2010
    ....
  12. pmc Reflex regulation during sustained and intermittent submaximal contractions in humans
    Jacques Duchateau
    Laboratory of Biology, Universite Libre de Bruxelles, 28 avenue P Héger, CP 168, Belgium
    J Physiol 541:959-67. 2002
    ..This decline in excitation to the motoneurones, however, can be temporarily compensated by an enhancement of the central drive...
  13. pmc Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation
    Gabrielle Todd
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
    J Physiol 551:661-71. 2003
    ....
  14. ncbi Unraveling the neurophysiology of muscle fatigue
    Roger M Enoka
    Department of Integrative Physiology, University of Colorado, Boulder, CO, USA
    J Electromyogr Kinesiol 21:208-19. 2011
    ..insight on the types of adjustments that occur in the nervous system during fatiguing contractions, but emphasize that much remains to be learned about the physiological processes that contribute to the phenomenon known as muscle fatigue.
  15. ncbi Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue
    Bernd W Pritschow
    Institute of Pathophysiology, University of Greifswald, Greifswald, Germany
    Pflugers Arch 461:115-22. 2011
    ..When soleus muscles were stimulated with a fatigue protocol, muscle fatigue was significantly attenuated in the presence of 4α-PDD...
  16. ncbi Transcranial magnetic stimulation and human muscle fatigue
    J L Taylor
    Prince of Wales Medical Research Institute and University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Muscle Nerve 24:18-29. 2001
    ..In some patients with symptoms of fatigue, the response to TMS after exercise is altered, but the changed MEP behavior is not yet linked to particular symptoms or pathology...
  17. ncbi Failed excitability of spinal motoneurons induced by prolonged running exercise
    S Racinais
    Faculté des Sciences du Sports, Laboratoire EA 2991, Efficience et Déficience Motrices, Universite de Montpellier 1, 700 Avenue du Pic Saint Loup, 34090 Montpellier, France
    J Neurophysiol 97:596-603. 2007
    ..In conclusion, the results regarding H-reflex and V-wave suggest for the first time a modulation in spinal loop properties after prolonged running...
  18. ncbi Locomotor exercise induces long-lasting impairments in the capacity of the human motor cortex to voluntarily activate knee extensor muscles
    Simranjit K Sidhu
    University of New South Wales, Sydney, Australia
    J Appl Physiol (1985) 106:556-65. 2009
    b>Muscle fatigue is a reduction in the capacity to exert force and may involve a "central" component originating in the brain and/or spinal cord...
  19. ncbi Exercise-induced muscle damage in humans
    Priscilla M Clarkson
    Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
    Am J Phys Med Rehabil 81:S52-69. 2002
    ....
  20. ncbi Muscle fatigue affects mental simulation of action
    Laurent Demougeot
    Universite de Bourgogne, Unité de Formation et de Recherche en Sciences et Techniques des Activité Physiques et Sportives, F 21078 Dijon, France
    J Neurosci 31:10712-20. 2011
    ..Here, we examined whether muscle fatigue could influence mental movements...
  21. ncbi Intracellular acidosis enhances the excitability of working muscle
    Thomas H Pedersen
    Department of Physiology, University of Aarhus, DK 8000, Denmark
    Science 305:1144-7. 2004
    Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working ..
  22. ncbi Free radicals and muscle fatigue: Of ROS, canaries, and the IOC
    Michael B Reid
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Free Radic Biol Med 44:169-79. 2008
    ..in humans, quadrupeds, and isolated muscle preparations indicate that antioxidant pretreatment can delay muscle fatigue. In humans, this phenomenon is best defined for N-acetylcysteine (NAC), a reduced thiol donor that supports ..
  23. ncbi Effect of lower-extremity muscle fatigue on postural control
    Phillip A Gribble
    Athletic Training Research Laboratory, Department of Kinesiology, Pennsylvania State University, University Park, PA, USA
    Arch Phys Med Rehabil 85:589-92. 2004
    ..To examine the effects of fatigue of the lower extremity on postural control during single-leg stance...
  24. pmc Muscle fatigue: what, why and how it influences muscle function
    Roger M Enoka
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Physiol 586:11-23. 2008
    Much is known about the physiological impairments that can cause muscle fatigue. It is known that fatigue can be caused by many different mechanisms, ranging from the accumulation of metabolites within muscle fibres to the generation of ..
  25. ncbi Neural and muscular adjustments following repeated running sprints
    Stephane Perrey
    Laboratoire EA 2991 Efficience et Déficience Motrices, UFR STAPS, Faculté des Sciences du Sports, Universite Montpellier 1, 700 Avenue du Pic Saint Loup, 34090, Montpellier, France
    Eur J Appl Physiol 109:1027-36. 2010
    ..Peak tetanus at 20 and 80 Hz were 17 and 8% lower (P < 0.05) in the fatigued state, respectively. Acute muscle fatigue induced by RS running exercise is mainly peripheral as the short-term (30 min) recovery pattern of plantar ..
  26. ncbi Alteration of the position sense at the ankle induced by muscular fatigue in humans
    Nicholas Forestier
    Division de kinesiologie, Universite Laval, Quebec, Canada
    Med Sci Sports Exerc 34:117-22. 2002
    ..The purpose of this study was to investigate how an isometric exhaustion test affects the position sense at the ankle using an active matching task...
  27. ncbi Effect of age on muscle functions investigated with surface electromyography
    Roberto Merletti
    Laboratorio di Ingegneria del Sistema Neuromuscolare, Dipartimento di Elettronica, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy
    Muscle Nerve 25:65-76. 2002
    ..electromyographic (EMG) signal as a means of defining age-related central and peripheral mechanisms affecting muscle fatigue. Spectral and temporal variables of the surface EMG signal were studied during voluntary isometric ..
  28. ncbi Central and peripheral fatigue kinetics during exhaustive constant-load cycling
    N Decorte
    Exercise Research Unit, University Hospital and HP2 Laboratory, Joseph Fourier University, Grenoble, France
    Scand J Med Sci Sports 22:381-91. 2012
    ..47 at 100 Hz, all P≤0.001). We conclude that peripheral fatigue develops early during constant-load intense cycling and is compensated by additional motor drive, while central fatigue appears to be associated with task failure...
  29. pmc The development of peripheral fatigue and short-term recovery during self-paced high-intensity exercise
    Christian Froyd
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Sports Science Instituteof South Africa, Boundary Road, Newlands, 7925, South Africa
    J Physiol 591:1339-46. 2013
    ..Significant recovery in skeletal muscle function occurs within the first 1-2 min after exercise, showing that previous studies may have underestimated the extent to which peripheral fatigue develops during exercise...
  30. pmc Effect of acute hypoxia on respiratory muscle fatigue in healthy humans
    Samuel Verges
    HP2 laboratory INSERM ERI17, Joseph Fourier University, Grenoble University Hospital, Grenoble, France
    Respir Res 11:109. 2010
    ..Hence, we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle fatigue.
  31. ncbi Comparison of potentiated and unpotentiated twitches as an index of muscle fatigue
    Thomas J Kufel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14215 USA
    Muscle Nerve 25:438-44. 2002
    ..005). The within-subject within-day coefficient of variation was 7.5 plus minus 0.5% for TwQu and 5.6 plus minus 0.9% for TwQp. Thus, TwQp is reproducible and is superior to TwQu for detecting early muscle fatigue.
  32. ncbi Evaluation of measurement strategies to increase the reliability of EMG indices to assess back muscle fatigue and recovery
    C LaRiviere
    Occupational Health and Safety Research Institute Robert Sauvé, Quebec, Montreal, Canada
    J Electromyogr Kinesiol 12:91-102. 2002
    ..74-0.79; SEM range: 21-26%). The assessment of back muscle impairments through EMG analysis necessitates the use of multiple electrodes to achieve reliable results...
  33. ncbi Muscle fatigue--from motor units to clinical symptoms
    Roger M Enoka
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Biomech 45:427-33. 2012
    ..examples of these limitations that were discussed in the 2011 Muybridge Award lecture: motor unit types and muscle fatigue, myoelectric manifestations of fatigue, and fatigue and fatigability...
  34. ncbi Re-weighting of somatosensory inputs from the foot and the ankle for controlling posture during quiet standing following trunk extensor muscles fatigue
    Nicolas Vuillerme
    Laboratoire TIMC IMAG, Faculte de Medecine, UMR UJF CNRS 5525, 38706, La Tronche Cedex, France
    Exp Brain Res 183:323-7. 2007
    ..This could have implications in clinical and rehabilitative areas...
  35. ncbi Effectiveness of exercise training in patients with COPD: the role of muscle fatigue
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences, Dept of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 40:338-44. 2012
    ..Patients who develop quadriceps contractile fatigue during exercise training show greater training effects in terms of functional exercise capacity and health-related quality of life...
  36. pmc Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans
    Markus Amann
    University of Utah, Department of Internal Medicine, Salt Lake City, UT, USA
    J Physiol 589:5299-309. 2011
    ..Our findings suggest that feedback from group III/IV muscle afferents limits CMD but also minimizes locomotor muscle fatigue development by stimulating adequate ventilatory and circulatory responses to exercise...
  37. ncbi Cerebrovascular responses to incremental exercise during hypobaric hypoxia: effect of oxygenation on maximal performance
    Andrew W Subudhi
    Department of Biology, University of Colorado at Colorado Springs, 1420 Austin Bluffs Parkway, Colorado Springs, CO 80918, USA
    Am J Physiol Heart Circ Physiol 294:H164-71. 2008
    ..Thus cerebral hypoxia appeared to impose a limit to maximal exercise during hypobaric hypoxia (Pi(O(2)) 86 Torr), since its reversal was associated with improved performance...
  38. ncbi Quadriceps fatigue after cycle exercise in patients with COPD compared with healthy control subjects
    M Jeffery Mador
    Division of Pulmonary, Critical Care, and Sleep Medicine, State University of New York at Buffalo, 14215, USA
    Chest 123:1104-11. 2003
    ..The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects...
  39. ncbi Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans
    Peter G Martin
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, New South Wales 2031, Australia
    J Neurosci 26:4796-802. 2006
    ..The more pronounced inhibitory influence of these afferents on extensors suggests that these muscles may require greater cortical drive to generate force during fatigue...
  40. pmc Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans
    Markus Amann
    University of Wisconsin Medical School, John Rankin Laboratory of Pulmonary Medicine, Madison, WI, USA
    J Physiol 581:389-403. 2007
    ....
  41. ncbi Physical fitness and performance. Fatigue responses during repeated sprints matched for initial mechanical output
    Alberto Mendez-Villanueva
    School of Human Movement and Exercise Science, The University of Western Australia, Perth, Australia
    Med Sci Sports Exerc 39:2219-25. 2007
    ..To compare muscle fatigability during two sets of repeated cycling sprints matched for initial mechanical output in a nonfatigued and fatigued state...
  42. ncbi Effects of electrical stimulation parameters on fatigue in skeletal muscle
    Ashraf S Gorgey
    Spinal Cord Injury and Disorders Center, Hunter Holmes McGuire VAMC, Richmond, VA 23249, USA
    J Orthop Sports Phys Ther 39:684-92. 2009
    ..Experimental laboratory study...
  43. ncbi Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis
    Konstantinos Margonis
    Department of Physical Education and Sports Science, Democritus University of Thrace, Komotini 69100, and Department of Internal Medicine, Henry Dunant Hospital, Athens, Greece
    Free Radic Biol Med 43:901-10. 2007
    ..In conclusion, overtraining induces a marked response of oxidative stress biomarkers which, in some cases, was proportional to training load, suggesting that they may serve as a tool for overtraining diagnosis...
  44. ncbi Muscular fatigue increases signal-dependent noise during isometric force production
    Olivier Missenard
    EA 2991, University Montpellier 1, 700 av du Pic Saint Loup, 34090 Montpellier, France
    Neurosci Lett 437:154-7. 2008
    ....
  45. ncbi Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans
    Ernesto Cesar Pinto Leal Junior
    Laboratory of Human Movement LMH, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, 95070 560, Rio Grande do Sul, Brazil
    Lasers Med Sci 24:425-31. 2009
    This study aimed to investigate the effect of 830 nm low-level laser therapy (LLLT) on skeletal muscle fatigue. Ten healthy male professional volleyball players entered a crossover randomized double-blinded placebo-controlled trial...
  46. ncbi Differences in quadriceps muscle strength and fatigue between lean and obese subjects
    Nicola A Maffiuletti
    Neuromuscular Research Laboratory, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland
    Eur J Appl Physiol 101:51-9. 2007
    ..Quadriceps muscle fatigue was quantified as the (percent) torque loss during a voluntary isokinetic (50 maximal contractions at 180 ..
  47. ncbi Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
    Nicolas Place
    Institute of Movement Sciences and Sport Medicine, Faculte de Medecine, Universite de Geneve, Rue du conseil général 10, 1205, Geneve, Switzerland
    Eur J Appl Physiol 110:1-15. 2010
    Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force...
  48. pmc A comparison of pain level and entropy changes following core stability exercise intervention
    Taero Lee
    Department of Healthcare Management, College of Health Science, Korea University, Seoul, Republic of Korea
    Med Sci Monit 17:CR362-8. 2011
    ....
  49. ncbi The effect of aging on skeletal-muscle recovery from exercise: possible implications for aging athletes
    James Fell
    School of Human Life Sciences, University of Tasmania, Launceston, Australia
    J Aging Phys Act 16:97-115. 2008
    ..Future research should use an exercise intervention representative of a normal training stimulus and take the physical activity level of the participants into account...
  50. ncbi The absence of eye muscle fatigue indicates that the nervous system compensates for non-motor disturbances of oculomotor function
    Mario Prsa
    Department of Cognitive Neurology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 30:15834-42. 2010
    ..The existence of this supplementary mechanism forces a reassessment of traditional views of cerebellum-dependent motor adaptation...
  51. ncbi 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1
    Chad R Hancock
    Medical Pharmacology and Physiology, College of Medicine, University of Missouri Columbia, Columbia, MO, USA
    Am J Physiol Cell Physiol 288:C1298-304. 2005
    ..Remarkably, the AK1(-/-) and WT muscles exhibited similar fatigue profiles. Our findings suggest that skeletal muscle is surprisingly tolerant to a large increase in ADP and by extension, a decline in energy from ATP...
  52. ncbi Changes in running kinematics, kinetics, and spring-mass behavior over a 24-h run
    Jean Benoit Morin
    Universite de Lyon, Saint Etienne, France
    Med Sci Sports Exerc 43:829-36. 2011
    ..This study investigated the changes in running mechanics and spring-mass behavior over a 24-h treadmill run (24TR)...
  53. ncbi The effect of carbohydrate ingestion on the interleukin-6 response to a 90-minute run time trial
    Paula Robson-Ansley
    School of Psychology and Sport Sciences, Northumbria University, Newcastle upon Tyne, UK
    Int J Sports Physiol Perform 4:186-94. 2009
    ..3+/-1.9 pg.mL(-1) and 6.6+/-3.0 pg.mL(-1), respectively; p=.0313), this difference was considered physiologically too small to mediate the improvement in time trial performance...
  54. pmc From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans
    T D Noakes
    Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Newlands, South Africa
    Br J Sports Med 38:511-4. 2004
    ..A revolutionary theory is presented that proposes that exercise performance is regulated by the central nervous system specifically to ensure that catastrophic physiological failure does not occur during normal exercise in humans...
  55. ncbi Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans
    Lee M Romer
    Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, UK
    Am J Physiol Regul Integr Comp Physiol 290:R365-75. 2006
    The effect of exercise-induced arterial hypoxemia (EIAH) on quadriceps muscle fatigue was assessed in 11 male endurance-trained subjects [peak O2 uptake (VO2 peak) = 56.4 +/- 2.8 ml x kg(-1) x min(-1); mean +/- SE]...
  56. ncbi Repeated bout effect on the cytoskeletal proteins titin, desmin, and dystrophin in rat skeletal muscle
    T Maarit Lehti
    LIKES Research Center for Sport and Health Sciences, Rautpohjankatu 8, Viveca, Jyvaskyla 40700, Finland
    J Muscle Res Cell Motil 28:39-47. 2007
    ..After five sessions increase in mRNA of studied proteins suggest a strong involvement in continuing adaptation to the increased exercise...
  57. pmc Improvement of diaphragm and limb muscle isotonic contractile performance by K+ channel blockade
    Erik van Lunteren
    Division of Pulmonary and Critical Care Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Neuroeng Rehabil 7:1. 2010
    ....
  58. ncbi The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain
    Lotte Janssens
    Musculoskeletal Research Unit, Department of Rehabilitation Sciences, University of Leuven K U Leuven, Tervuursevest 101, Leuven, Belgium
    Spine (Phila Pa 1976) 35:1088-94. 2010
    ..A 2-group experimental design...
  59. ncbi Muscle weakness and atrophy are associated with decreased regenerative capacity and changes in mTOR signaling in skeletal muscles of venerable (18-24-month-old) dystrophic mdx mice
    E Mouisel
    INSERM U974 CNRS UMR 7215, 105 bd de l Hopital, 75634 Paris Cedex 13, F 75013 France
    Muscle Nerve 41:809-18. 2010
    ..Progressive muscle weakness and atrophy in mdx mouse muscle is associated with a decline in regenerative potential and changes in activation of the mTOR signaling pathway...
  60. pmc Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance
    Markus Amann
    The John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA
    J Physiol 586:161-73. 2008
    We asked whether the central effects of fatiguing locomotor muscle fatigue exert an inhibitory influence on central motor drive to regulate the total degree of peripheral fatigue development...
  61. ncbi Contractile leg fatigue after cycle exercise: a factor limiting exercise in patients with chronic obstructive pulmonary disease
    Didier Saey
    Centre de Pneumologie, Hopital Laval, 2725 Chemin Ste Foy, Ste Foy, PQ, G1V 4G5 Canada
    Am J Respir Crit Care Med 168:425-30. 2003
    ..These tests were preceded by nebulization of placebo or 500 microg of ipratropium bromide. Muscle fatigue was defined as a postexercise reduction in quadriceps twitch force of more than 15% of the resting value...
  62. ncbi Diurnal variations of plasma homocysteine, total antioxidant status, and biological markers of muscle injury during repeated sprint: effect on performance and muscle fatigue--a pilot study
    Omar Hammouda
    Research Laboratory, Sport Performance Optimization, National Centre of Medicine and Science in Sport, Tunis, Tunisia
    Chronobiol Int 28:958-67. 2011
    ..to establish a relationship between diurnal variation of these biomarkers and the daytime rhythm of power and muscle fatigue during repeated sprint ability (RSA) exercise...
  63. ncbi Relevance of assessing quadriceps endurance in patients with COPD
    C Coronell
    Muscle and Respiratory Research Unit, Municipal Institute of Medical Research, Servei de Pneumologia, Hospital del Mar, CEXS Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Eur Respir J 24:129-36. 2004
    ..Task failure occurred only in COPD patients and was due to muscle fatigue, since limiting symptoms were associated with a decrease in the median frequency of quadriceps ..
  64. ncbi The cross-bridge cycle and skeletal muscle fatigue
    Robert H Fitts
    Dept of Biological Sciences, Wehr Life Sciences Bldg, Marquette Univ, P O Box 1881, Milwaukee, WI 53201 1881, USA
    J Appl Physiol (1985) 104:551-8. 2008
    ..In vitro, reactive oxygen species reduce myofibrillar Ca2+ sensitivity; however, the importance of this mechanism during in vivo exercise is unknown...
  65. ncbi Multichannel surface EMG: basic aspects and clinical utility
    Machiel J Zwarts
    Department of Clinical Neurophysiology, Institute of Neurology, University Medical Center Nijmegen, PO Box 9101, NL 6500HB Nijmegen, The Netherlands
    Muscle Nerve 28:1-17. 2003
    ..We conclude that multichannel sEMG adds unique, and sometimes indispensable, spatial information to our knowledge of the motor unit...
  66. ncbi Lactic acid and exercise performance : culprit or friend?
    Simeon P Cairns
    Institute of Sport and Recreation Research New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand
    Sports Med 36:279-91. 2006
    ..accumulation of lactic acid, or in reality lactate and/or hydrogen (H+) ions, is a major cause of skeletal muscle fatigue, i.e. decline of muscle force or power output leading to impaired exercise performance...
  67. ncbi Recruitment patterns in human skeletal muscle during electrical stimulation
    Chris M Gregory
    Department of Physical Therapy, University of Florida, Room 1142, HPNP Bldg, 101 S Newell Dr, Gainesville, FL 32610, USA
    Phys Ther 85:358-64. 2005
    ..synthesizes the evidence that supports the contention that this recruitment pattern contributes to increased muscle fatigue when compared with voluntary actions...
  68. ncbi Muscle fatigue: lactic acid or inorganic phosphate the major cause?
    Hakan Westerblad
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    News Physiol Sci 17:17-21. 2002
    ..acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Recent studies on mammalian muscle, however, show little direct effect of acidosis on muscle function at ..
  69. ncbi Multifidi muscles median frequency before and after spinal stabilization exercises
    Paul S Sung
    Iowa Spine Research Center, Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    Arch Phys Med Rehabil 84:1313-8. 2003
    ..To determine changes in multifidi muscle endurance and functional status after a 4-week spinal stabilization exercise program for patients presenting with chronic low back dysfunction (LBD)...
  70. ncbi Muscle-derived ROS and thiol regulation in muscle fatigue
    Leonardo F Ferreira
    Department of Physiology, University of Kentucky, 800 Rose St, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 104:853-60. 2008
    ..that supports glutathione synthesis, has been shown to lessen oxidation of cellular constituents and delay muscle fatigue. In humans, NAC pretreatment improves performance of limb and respiratory muscles during fatigue protocols and ..
  71. ncbi Evidence for a supraspinal contribution to human muscle fatigue
    Janet L Taylor
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 33:400-5. 2006
    1. Muscle fatigue can be defined as any exercise-induced loss of ability to produce force with a muscle or muscle group. It involves processes at all levels of the motor pathway between the brain and the muscle...
  72. pmc The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue
    Chris J McNeil
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, New South Wales 2031, Australia
    J Physiol 587:5601-12. 2009
    ..The spinal mechanisms exposed here may contribute to the development of central fatigue in human muscles...
  73. ncbi Comparison of electrical and magnetic stimulations to assess quadriceps muscle function
    Samuel Verges
    Joseph Fourier University, France
    J Appl Physiol (1985) 106:701-10. 2009
    ..46-0.82, P = 0.001-0.03). We conclude that ENS and MNS provide similar quadriceps muscle function assessment, while Fpaired(10:100) is a better index than T2(10:100) of low- to high-frequency fatigue of the quadriceps in vivo...
  74. pmc Age- and gender-related changes in contractile properties of non-atrophied EDL muscle
    Stephen Chan
    School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 5:e12345. 2010
    ..However, it is not entirely clear whether these changes in contractile properties can occur before there is significant atrophy, and whether males and females are affected differently...
  75. ncbi A mathematical model of fatigue in skeletal muscle force contraction
    Paul R Shorten
    AgResearch Limited, Ruakura Research Centre, Private Bag, 3123, Hamilton, New Zealand
    J Muscle Res Cell Motil 28:293-313. 2007
    The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway...
  76. ncbi Symptoms and quadriceps fatigability after walking and cycling in chronic obstructive pulmonary disease
    William D C Man
    Respiratory Muscle Laboratory, Guy s King s and St Thomas School of Medicine, King s College Hospital, Bessemer Road, London SE5 9PJ UK
    Am J Respir Crit Care Med 168:562-7. 2003
    ..01; potentiated p = 0.003). Leg effort is an infrequent symptom after walking in COPD, and low frequency fatigue of the quadriceps is an infrequent feature of incremental walking...
  77. ncbi Effects of muscle fatigue induced by low-level clenching on experimental muscle pain and resting jaw muscle activity: gender differences
    Tetsurou Torisu
    Center for Sensory Motor Interaction, Laboratory for Human Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7 D 3, 9220 Aalborg, Denmark
    Exp Brain Res 174:566-74. 2006
    The purpose of this study was to investigate the effects of jaw-muscle fatigue evoked by low-level tooth-clenching followed by the induction of experimental muscle pain by injection of glutamate on the perception of fatigue and pain and ..
  78. ncbi Upper trapezius muscle mechanomyographic and electromyographic activity in humans during low force fatiguing and non-fatiguing contractions
    Pascal Madeleine
    Centre for Sensory Motor Interaction, Aalborg University, Fredrik Bajers Vej 7, Bldg D 3, 9220 Aalborg, Denmark
    Eur J Appl Physiol 87:327-36. 2002
    ..For fatiguing contractions, normalisation of the EMG and MMG to some extent can lead to a misleading interpretation. Assessment of the upper trapezius muscle by means of MMG may be valuable in ergonomics...
  79. ncbi Central and peripheral fatigue during passive and exercise-induced hyperthermia
    Julien D Périard
    ASPETAR, Research and Education Centre, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar
    Med Sci Sports Exerc 43:1657-65. 2011
    ..The influence of cardiovascular strain in limiting endurance performance in the heat was also examined...
  80. ncbi Intensity of eccentric exercise, shift of optimum angle, and the magnitude of repeated-bout effect
    Trevor C Chen
    Department of Physical Education, National Chiayi University, Taiwan
    J Appl Physiol 102:992-9. 2007
    ..05) reduced changes in criterion measures following ECC2 compared with the ECC1 100% bout. We conclude that the repeated-bout effect was not dependent on the shift of optimum angle...
  81. ncbi Contractile fatigue, muscle morphometry, and blood lactate in chronic obstructive pulmonary disease
    Didier Saey
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Quebec, Canada
    Am J Respir Crit Care Med 171:1109-15. 2005
    ..We conclude that changes in muscle enzymatic profile and capillarization with a greater reliance on glycolytic metabolism during exercise are associated with contractile fatigue in patients with chronic obstructive pulmonary disease...
  82. ncbi Factors responsible for force steadiness impairment with fatigue
    Olivier Missenard
    Motor Efficiency and Deficiency Laboratory, University Montpellier 1, EA 2991, 700 Avenue du Pic Saint Loup, 34090 Montpellier, France
    Muscle Nerve 40:1019-32. 2009
    ..We conclude that the impairment of force steadiness with fatigue is mainly due to the increase in muscle activation at moderate forces, but there are other central sources of force fluctuation present at low force levels...
  83. ncbi Neuromuscular function after muscle fatigue in Charcot-Marie-Tooth type 1A patients
    Federica Menotti
    Department of Human Movement and Sport Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 6, 00135 Rome, Italy
    Muscle Nerve 46:434-9. 2012
    ..The effect of recovery time on neuromuscular function after a fatiguing task was compared in both the upper and lower limbs between patients with Charcot-Marie-Tooth type 1A (CMT1A) and healthy individuals...
  84. ncbi Functional investigations of exercising muscle: a noninvasive magnetic resonance spectroscopy-magnetic resonance imaging approach
    D Bendahan
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille, France
    Cell Mol Life Sci 61:1001-15. 2004
    b>Muscle fatigue, which is defined as the decline in muscle performance during exercise, may occur at different sites along the pathway from the central nervous system through to the intramuscular contractile machinery...
  85. pmc Influence of fatigue in neuromuscular control of spinal stability
    Kevin P Granata
    University of Virginia, Charlottesville, Virginia, USA
    Hum Factors 46:81-91. 2004
    ..Potential applications of this research include a biomechanical tool for the design of administrative ergonomic controls in manual materials handling industries...
  86. ncbi Neuromuscular fatigue in healthy muscle: underlying factors and adaptation mechanisms
    S Boyas
    EA 4334, UFR STAPS de Nantes, Laboratoire Motricite, Interactions, Performance, Universite de Nantes, 25 bis, boulevard Guy Mollet, 44322 Nantes Cedex 3, France
    Ann Phys Rehabil Med 54:88-108. 2011
    ..This review also addresses the literature that focuses on the mechanisms responsible for the adaption to neuromuscular fatigue...
  87. ncbi Effects of different pedalling techniques on muscle fatigue and mechanical efficiency during prolonged cycling
    J Theurel
    Institute of Movement Sciences E J Marey, UMR CNRS 6233, Aix Marseille University, Parc Scientifique et Technologique de Luminy, Marseille, France
    Scand J Med Sci Sports 22:714-21. 2012
    ..0 ± 1.9% vs PT: 20.2 ± 1.9%). Although changes in muscular coordination pattern with feedback did not seem to influence GE, it could be mainly responsible for the reduction of muscle fatigue after prolonged cycling.
  88. ncbi Assessment of the reliability of central and peripheral fatigue after sustained maximal voluntary contraction of the quadriceps muscle
    Nicolas Place
    INSERM ERM 207 Motricité Plasticité, Faculte des Sciences du Sport, Universite de Bourgogne, BP 27877, 21078 Dijon, France
    Muscle Nerve 35:486-95. 2007
    ..These findings can be useful in the choice of the parameters describing central and peripheral fatigue of the quadriceps muscle in future studies...
  89. ncbi Reflex and intrinsic changes induced by fatigue of human elbow extensor muscles
    L Q Zhang
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Northwestern University, Chicago, IL 60611, USA
    J Neurophysiol 86:1086-94. 2001
    ..In short, the reduced contribution from intrinsic stiffness to joint torque was compensated by increased contribution from dynamic stretch reflexes after fatigue...
  90. ncbi Effects of dietary supplementation with vitamins C and E on muscle function during and after eccentric contractions in humans
    A Shafat
    Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland
    Eur J Appl Physiol 93:196-202. 2004
    ..These data suggest that prior supplementation with dietary antioxidants ameliorates muscle functional decrements subsequent to eccentric muscle contraction...
  91. ncbi Changes in postural stability with fatigue of lower extremity frontal and sagittal plane movers
    Mahyar Salavati
    University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Gait Posture 26:214-8. 2007
    ..Biodex Stability System was used to assess anterior/posterior and medial/lateral stability before and after muscle fatigue. Repeated measures ANOVAs revealed that fatigue was associated with a significant increase in all stability ..
  92. pmc Effectiveness of post-match recovery strategies in rugby players
    N D Gill
    Waikato Institute of Technology, School of Sport and Exercise Science, Hamilton, New Zealand
    Br J Sports Med 40:260-3. 2006
    ..To examine the effectiveness of four interventions on the rate and magnitude of muscle damage recovery, as measured by creatine kinase (CK)...
  93. ncbi Effect of light finger touch on postural sway after lower-limb muscular fatigue
    Nicolas Vuillerme
    Universite Joseph Fourier Grenoble 1, France
    Arch Phys Med Rehabil 84:1560-3. 2003
    ..To investigate whether a light finger touch can compensate for the increased postural sway induced by lower-limb muscular fatigue...
  94. ncbi Skeletal muscle fatigue in long-distance runners, sprinters and untrained men after repeated drop jumps performed at maximal intensity
    A Skurvydas
    Laboratory of Human Motorics, Department of Physiology and Biochemistry, Lithuanian Academy of Physical Education, Sporto 6, LT 3029 Kaunas, Lithuania
    Scand J Med Sci Sports 12:34-9. 2002
    ....
  95. ncbi Interleukin-6 and its mRNA responses in exercise and recovery: relationship to muscle glycogen
    J E Gusba
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Scand J Med Sci Sports 18:77-85. 2008
    ..05) and 40% in the carbohydrate and water trials, respectively. Therefore, the declining IL-6 mRNA and IL-6 plasma concentrations during recovery were not related to carbohydrate availability or changes in glycogen...
  96. ncbi Impact of varying pulse frequency and duration on muscle torque production and fatigue
    Chris M Gregory
    Brain Rehabilitation Research Center, North Florida South Georgia Veterans Health System Department of Physical Therapy, University of Florida, Gainesville, Florida 32610, USA
    Muscle Nerve 35:504-9. 2007
    ..These data demonstrate the ability to predictably control torque output by simultaneously controlling pulse frequency and duration and suggest the need to minimize stimulation frequency to control fatigue...
  97. ncbi Preliminary evaluation of a controlled-brake orthosis for FES-aided gait
    Michael Goldfarb
    Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Neural Syst Rehabil Eng 11:241-8. 2003
    ..that incorporates a computer-controlled orthosis system has been developed to address the problems of rapid muscle fatigue and poor movement control that are characteristic of FES-aided gait...
  98. ncbi A predictive fatigue model--I: Predicting the effect of stimulation frequency and pattern on fatigue
    Jun Ding
    Interdisciplinary Graduate Program in Biomechanics and Movement Science, University of Delaware, Newark 19716, USA
    IEEE Trans Neural Syst Rehabil Eng 10:48-58. 2002
    ..In addition, the present models successfully predict the effect of stimulation frequency and pulse pattern on muscle fatigue. The success of our current force- and fatigue-model system suggests its potential use in helping to identify ..
  99. ncbi Muscle fatigue during football match-play
    Thomas Reilly
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
    Sports Med 38:357-67. 2008
    ..There is also a role for endurance training and for a pacing strategy that optimizes the expenditure of energy during match-play...
  100. ncbi Central excitability does not limit postfatigue voluntary activation of quadriceps femoris
    J M Kalmar
    Department of Biology, Rm 346, Bethune College, York University, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    J Appl Physiol 100:1757-64. 2006
    ..05) at Tlim. However, this was not associated with enhanced maximal voluntary activation during fatigue or recovery, demonstrating that voluntary activation is not limited by central excitability...
  101. ncbi Slower conduction velocity and motor unit discharge frequency are associated with muscle fatigue during isometric exercise in type 1 diabetes mellitus
    S Almeida
    School of Kinesiology and Health Science, Faculty of Health, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada
    Muscle Nerve 37:231-40. 2008
    ..Persons with T1DM had slower conduction velocities and lower MUDF than their controls, which apparently leads to impaired activation of muscle and decreased endurance during isometric fatigue...

Research Grants63

  1. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..Signals also decay during fatigue -their decay actually causing fatigue-- and in old age. In muscle fatigue, the stores are depleted...
  2. Prevalence and Impact of Frailty among Dialysis Patients
    Kirsten L Johansen; Fiscal Year: 2013
    ..The first will extend Dr. Johansen's recent work evaluating the effects of oxidative stress on muscle fatigue to determine whether markers of oxidative stress are also associated with expression of proteins involved in ..
  3. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..clinical trial to determine if the drug tadalafil (Cialis), which has bee shown to improve blood flow and muscle fatigue in mice with muscular dystrophy, could be the first ever treatment to improve exercise tolerance in boys with ..
  4. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..including the need for manual stimulation parameter tuning, and inability to alter stimulation parameters on muscle fatigue or changing metabolic demand...
  5. POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
    Kathleen C Light; Fiscal Year: 2013
    ..Until recently, the peripheral processes involved in sensing muscle fatigue and pain were unknown;however, animal model studies by our group and others have clarified that a complex of ..
  6. ERalpha and the metabolic syndrome
    Andrea L Hevener; Fiscal Year: 2013
    ..Indeed our findings show accelerated muscle fatigue and impaired exercise-mediated induction of factors controlling mitochondrial turnover in muscle-specific ER1 ..
  7. Systems Biology Investigation of Muscle Exercise Metabolism in Diabetes
    Nicola Lai; Fiscal Year: 2013
    ..of metabolic and physiological systems;b) exercise and insulin resistance in skeletal muscle;c) skeletal muscle fatigue and metabolism...
  8. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..ES is delivered at a relatively high frequency between 20 and 35 Hz, which can lead to more rapid onset of muscle fatigue.7 Third, due to stimulation-induced pain and muscle fatigue, an escalating stimulation schedule is needed...
  9. Fatigability, Gender, and Optimal Stimulation Parameters after Spinal Cord Injury
    CHRISTOPHER S BICKEL; Fiscal Year: 2010
    ..b>Muscle fatigue is a major issue related to the efficacy of neuromuscular electrical stimulation (NMES) to improving activity ..
  10. Molecular Physiology of CLC Chloride Channels
    Tsung Yu Chen; Fiscal Year: 2012
    ..Physiologically, the inhibition of CLC-1's common-gating by ATP is critical for overcoming muscle fatigue. The slow/common-gating mechanism is also pathologically important because mutations that disrupt the common- ..
  11. A Joint-Coupled Controlled-Brake Orthosis System for Hybrid FES Gait Restoration
    Michael Goldfarb; Fiscal Year: 2013
    ..Due to the potential of collapse (from muscle fatigue) and the need to guide uncontrolled degrees of freedom, hybrid systems appear to offer the greatest promise ..
  12. An Exotendon Prosthesis to Improve Walking for Lower Limb Amputees
    BRIAN GLAISTER; Fiscal Year: 2012
    ..Lastly, in Specific Aim 4 of Phase II, we will perform a case series to evaluate the ability of the exotendon prosthesis to facilitate walking for amputees with limited abilities to ambulate. ..
  13. Nox2-Calcium Signaling in Skeletal Muscle
    George G Rodney; Fiscal Year: 2013
    ..Furthermore, it will lay the foundation for the development of targeted antioxidant therapy to combat the deleterious effects of overproduction of ROS seen in muscle fatigue and disease.
  14. The role of mitochondria in skeletal muscle fatigue caused by cancer chemotherapy
    LAURA ANN ASHLEY GILLIAM; Fiscal Year: 2013
    ..function and cellular redox state conducted on permeabilized fiber bundles in conjunction with whole muscle fatigue analysis...
  15. Isoform-specific roles of the Na,K-ATPase in skeletal muscle
    Jerry B Lingrel; Fiscal Year: 2013
    ..activation during contraction;b, Determine the contribution of altered Na,K-ATPase content or function to muscle fatigue and exercise intolerance in heart failure...
  16. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
    ..Performance measures will include maximal oxygen consumption (VO2max), muscle strength, muscle fatigue rate, and the onset of blood lactate accumulation (OBLA) during strenuous exercise...
  17. Mechanism and function of a novel purinergic signaling cascade in skeletal muscle
    ANDREW ALVIN VOSS; Fiscal Year: 2013
    ..and examining the physiological role of a novel purinergic signaling cascade, the results from the proposed studies will have implications for exercise-related muscle fatigue, muscle disuse, and disorders such as myotonia congenita.
  18. Respiratory muscle work and oxidative stress in COPD: impact on leg blood flow an
    Markus Amann; Fiscal Year: 2011
    ..exercise to examine the effects of both, the reduced work of breathing and the reduced oxidative stress on muscle fatigue in the exercising legs...
  19. Electromechanical Modeling Approach in Assessing Female SUI
    Yingchun Zhang; Fiscal Year: 2011
    ..these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women...
  20. Work of Breathing and Oxidative Stress in COPD: Impact on Blood Flow and Fatigue
    Markus Amann; Fiscal Year: 2013
    ..exercise to examine the effects of both, the reduced work of breathing and the reduced oxidative stress on muscle fatigue in the exercising legs...
  21. Effects of Localized Muscle Fatigue on Risk of Occupational Slips and Falls
    Thurmon E Lockhart; Fiscal Year: 2012
    ..The literature provides convincing arguments that localized muscle fatigue can disrupt the quality of the signal from the periphery for effective balance control during slip ..
  22. A Neural Prosthesis for the Restoration of Locomotion after Spinal Cord Injury
    KEVIN ANDREW MAZUREK; Fiscal Year: 2013
    ..it will produce stimulation patterns which can adapt to perturbations such as slipping, tripping, and muscle fatigue by utilizing the afferent feedback...
  23. SKELETAL MUSCLE BEHAVIOR IN HEART FAILURE
    John Wilson; Fiscal Year: 1990
    ..failure is due to a reduction in muscle O2 delivery and/or muscle oxidative capacity, and 3) to determine if muscle fatigue is due to muscle lactic acidosis...
  24. MICROMECHANICS OF RESPIRATORY MUSCLES
    ALADIN BORIEK; Fiscal Year: 1999
    ..Furthermore, respiratory muscle fatigue is believed to be the proximate cause of hypercarbic respiratory failure, which causes the death of many ..
  25. Electromechanical Modeling Approach in Assessing Female SUI
    Yingchun Zhang; Fiscal Year: 2013
    ..these Hypotheses: SA #1: To develop a subject- specific electrophysiological pelvic model based periurethral muscle fatigue assessment (UMFA) technique to minimally invasively and quantitatively assess urethral function in women...
  26. Noninvasive assessment of skeletal muscle integrity and function with statin use
    Jill Slade; Fiscal Year: 2009
    ..on mitochondrial function by measuring the change in muscle aerobic capacity primarily with phosphorus NMR and muscle fatigue. Aim 3 will examine the effect of statins on skeletal muscle function including changes in maximal strength ..
  27. Changes in Control of Movement Timing and Stability With Muscle Fatigue
    JONATHAN DINGWELL; Fiscal Year: 2009
    ..Work-related musculoskeletal injuries have been linked to movement repetition, improper postures, and muscle fatigue. Muscle fatigue and/or the muscle imbalances that result from fatigue may be important as direct causes and/or ..
  28. TESTOSTERONE EFFECTS ON DIAPHRAGM MUSCLE FATIGUE
    Cesar Blanco; Fiscal Year: 2002
    ..Identical AAS treatment of male rats had no effect on DIA muscle fatigue using the same stimulation paradigm...
  29. NURSING MODEL--RESPIRATORY MUSCLE STRENGTH IN COPD
    Janet Larson; Fiscal Year: 2001
    ..functional strength of the inspiratory muscles which places them at risk for the development of respiratory muscle fatigue and ventilatory failure and contributes to sensations of dyspnea and ultimately to a decrease in functional ..
  30. THE BIOMECHANICS OF OCCUPATIONAL SHOULDER INJURIES
    Andrew Karduna; Fiscal Year: 2001
    ..There is evidence that repetitive motion is associated with muscle fatigue and abnormal shoulder motion, which in turn may lead to damage of the rotator cuff musculature...
  31. CLASSIFICATION OF TMDS--VALIDITY & UTILITY OF RDC AXIS I
    Thomas Rudy; Fiscal Year: 1999
    ..Validation the Axis I EDPs requires objective evaluation of bite force and masticatory muscle fatigue, temporomandibular joint (TMJ) sounds, dynamic motion analysis of jaw movements, and jaw imaging...
  32. BIOCHEMISTRY AND PHYSIOLOGY OF SINGLE MOTOR UNITS
    PATTI NEMETH; Fiscal Year: 1993
    This research seeks to understand the metabolic basis of muscle fatigue by examining the quantitative relationship between energy metabolism and fatigability at the level of individual motor units...
  33. RESPIRATORY SYSTEM MECHANICS
    ALADIN BORIEK; Fiscal Year: 2002
    ..Respiratory insufficiency is the usual cause of death in many primary neuromuscular disorders. Respiratory muscle fatigue is believed to be a major factor in hypercarbic respiratory failure associated with lung and/or cardiovascular ..
  34. Drug-Induced Motor Recovery After Spinal Cord Injury
    Kwaku Nantwi; Fiscal Year: 2005
    ..First, we will focus in on selective peripherally-mediated mechanisms that can minimize respiratory muscle fatigue that may be attendant to prolonged methylxanthine (theophylline) use...
  35. DIAPHRAGM ADAPTATIONS TO CHRONIC RESISTIVE LOADING
    David Prezant; Fiscal Year: 2001
    ..abstract): Long-term goal: In patients with chronic obstructive pulmonary diseases (COPD), respiratory muscle fatigue resistance must be increased to maintain ventilation in the face of chronic respiratory resistive loading (..
  36. Role of MG29 in E-C Coupling of Striated Muscles
    Jianjie Ma; Fiscal Year: 2006
    ..A distinct phenotype of mg29(-/-) mice is their increased susceptibility to muscle fatigue, which may be linked to an altered Ca signaling in the mutant muscle...
  37. FUNCTIONAL TREATMENT APPROACH TO STRESS INCONTINENCE
    Diane Borello France; Fiscal Year: 1999
    ..we will determine exercise progression using a protocol that individualizes exercise prescription based on muscle fatigue. At each weekly assessment, we will adjust the subject's HEP accordingly...
  38. "Strength training, Self-efficacy, and Function in Blacks with Prostate Cancer."
    Bernard Hurley; Fiscal Year: 2009
    ..impact of a high-quality ST intervention program on muscle size, muscle function, muscle and fat composition, muscle fatigue, fatigue perception, blood proteins associated with PCa, quality of life, willingness to continue to ST and ..
  39. Regulation of cardiac ion channel function via allosteric modulators
    Andrew Marks; Fiscal Year: 2007
    ..Skeletal muscle fatigue is increased and RyR1 are PKA hyperphosphorylated and depleted of calstabin1 in HF, and JTV519 induces ..
  40. FREE RADICALS AND RESPIRATORY LOADING
    GERALD SUPINSKI; Fiscal Year: 1999
    ..radicals are generated in the diaphragm during strenuous contractions and may contribute to the development of muscle fatigue. Previous experiments have been limited, however, to the investigation of either electrically induced fatigue ..
  41. EXERCISE INTOLERANCE IN CONGESTIVE HEART FAILURE
    JOHN MINOTTI; Fiscal Year: 1993
    ..The aims of the present proposal are: (1) to determine whether the mechanism of muscle fatigue is impaired central drive or altered muscle function; (2) to determine whether CHF patients exhibit the same ..
  42. CONTROL OF MYOSIN TYPES IN INDIVIDUAL MUSCLE FIBERS
    Neal Rubinstein; Fiscal Year: 1993
    ..be implicated in the genesis or symptomotology of muscle diseases such as floppy infant syndrome, respiratory muscle fatigue, or hypo- and hyperthyroidism...
  43. Calmodulin regulation of SR calcium release channels
    Bradley Fruen; Fiscal Year: 2007
    ..regulatory proteins is postulated to contribute to impaired contractile performance during oxidative stress, muscle fatigue, and heart disease...
  44. WORKLOAD EFFECT ON TASK PERFORMANCE ON INCLINED SURFACE
    Amit Bhattacharya; Fiscal Year: 1999
    ..demanding tasks on inclined/elevated surfaces 2) to determine the need of visual cues to minimize excessive postural muscle fatigue and provide a safe upright balance maintenance while working on an inclined and/or elevated surfaces.
  45. CARDIAC ASSIST DEVICES ENERGIZED BY SKELETAL MUSCLE
    Larry Stephenson; Fiscal Year: 2000
    ..that might be possible, to an SMV that pumped blood in the circulation for several hours indicating that muscle fatigue was no longer a major obstacle, to an SMV that has pumped blood effectively in the circulation beyond four ..
  46. CENTRAL NERVOUS SYSTEM AND MUSCLE FATIGUE
    Guang Yue; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Applicant's Abstract): Muscle fatigue has been studied for over a century...
  47. PHYSIOLOGIC BASIS OF MUSCLE FUNCTIONAL MRI
    RONALD MEYER; Fiscal Year: 2005
    ..involvement in various fatigue syndromes: first, is the intensity of the BOLD response in motor cortical areas quantitatively dependent on force development, and second, how is this central response altered by peripheral muscle fatigue?
  48. Effects of N-acetylcystein on Muscle Fatigue in ESRD
    KIRSTEN JOHANSEN; Fiscal Year: 2007
    ..We recently reported that ESRD patients experience approximately three-fold greater muscle fatigue of the lower extremities during intermittent submaximal contractions than healthy sedentary control subjects, ..
  49. Effects of Repetitive Work on Fatigue of Long Duration
    STEVEN LEHMAN; Fiscal Year: 2004
    ..b>Muscle fatigue of long duration, also known as low frequency fatigue, increases with exposure and can persist for more than ..
  50. FATIGUE OF SEGMENTAL MOTOR MECHANISMS
    DOUGLAS STUART; Fiscal Year: 2000
    ..It is well established that in a variety of normal and pathophysiological conditions, the manifestation of muscle fatigue is attributable to mechanisms that extend from the forebrain of the central nervous system (CNS) to the ..
  51. NOVEL CREATINE SUPPLEMENTS FOR ENHANCING MUSCLE FUNCTON
    HUAIYUN HAN; Fiscal Year: 2002
    ..allow increased use of creatine supplement to augment and complement existing treatments for conditions where muscle fatigue and weakness are a problem...
  52. DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
    David Prezant; Fiscal Year: 1992
    Respiratory muscle fatigue and mechanical ventilator dependency contribute significantly to the morbidity and mortality of patients suffereing from chronic pulmonary disease...
  53. Redox Control of Sarcoplasmic Reticulum Calcium Release
    JONATHAN ABRAMSON; Fiscal Year: 2006
    ..Oxidative stress results from cardiac ischemia and reperfusion, and in skeletal muscle results in muscle fatigue. The molecular mechanism by which the SR controls and responds to changes in its redox environment, and how ..
  54. NEUROPHYSIOLOGICAL CONSEQUENCES OF LUMBAR FACET MOVEMENT
    Joel Pickar; Fiscal Year: 2001
    ....
  55. RESPIRATORY MUSCLE ENERGETICS DURING EXERCISE
    Murli Manohar; Fiscal Year: 1992
    Recent reports of inspiratory muscle fatigue in athletes following both high-intensity short-term as well as prolonged endurance exercise have focussed our attention on the question "whether the metabolic O2 requirements of the ..
  56. EFFECT OF LOCALIZED FATIGUE ON POSTURAL STABILITY
    RICHARD WICKSTROM; Fiscal Year: 1990
    ..Localized muscle fatigue is an important risk factor for slips and falls in the high risk construction and manufacturing industries, ..
  57. FUNCTIONAL CARDIAC ASSISTANCE WITH SKELETAL MUSCLE POUCH
    Stephen Badylak; Fiscal Year: 1990
    ..skeletal muscles would most efficiently assist the circulation has not been determined, and the problems of muscle fatigue and lack of a suitable pulse generator to stimulate and coordinate skeletal muscle work are limitations to ..
  58. SKELETAL MUSCLE FUNCTION IN AGING
    Jane Kent Braun; Fiscal Year: 1999
    ..Year 1); 2) to test the hypothesis that muscle oxidative capacity is reduced in aging (Year 2); 3) to examine muscle fatigue in elderly and young subjects (Year 3); and 4) to determine the effects of exercise training on muscle ..
  59. Weight-loss, Exercise, and Oxidative Capacity in Obesity
    Matthew Harber; Fiscal Year: 2005
    ..factors and target proteins that regulate muscle oxidative metabolism, and assess changes in whole-muscle fatigue resistance after weight loss in pre-diabetic obese women...
  60. SUDDEN LOADING AND FATIGUE EFFECTS ON THE HUMAN SPINE
    Daniel Baker; Fiscal Year: 1990
    ..The data will be analyzed and compared to current bio-mechanical models. Muscle fatigue will be induced through a series of graded exercises for three levels of fatigue (rested, moderate fatigue, ..
  61. Neuromuscular Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2008
    ..Recent studies indicate that older adults experience greater muscle fatigue than young adults during these more functionally relevant tasks...
  62. Task Dependence of Muscle Fatigue in Older Adults
    Sandra Hunter; Fiscal Year: 2005
    ..However, the influence of age-related changes within the neuromuscular system on the task-dependent nature of muscle fatigue is unexplored in older adults...
  63. MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY
    RICHARD SHIELDS; Fiscal Year: 2003
    ..Associated with muscle fatigue is a severe loss of bone density...