locomotion

Summary

Summary: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.

Top Publications

  1. pmc The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span
    Ji Wu Wang
    Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 121:4118-26. 2011
  2. pmc Patterned control of human locomotion
    Francesco Lacquaniti
    Department of Systems Medicine, Neuroscience Section, University of Rome Tor Vergata, 00133 Rome, Italy
    J Physiol 590:2189-99. 2012
  3. ncbi Restoring voluntary control of locomotion after paralyzing spinal cord injury
    Rubia van den Brand
    Neurology Department, University of Zurich, Ch 8008 Zurich, Switzerland
    Science 336:1182-5. 2012
  4. pmc Circuits controlling vertebrate locomotion: moving in a new direction
    Martyn Goulding
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:507-18. 2009
  5. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
  6. pmc Organization of mammalian locomotor rhythm and pattern generation
    David A McCrea
    Spinal Cord Research Centre and Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba R3E 3J7, Canada
    Brain Res Rev 57:134-46. 2008
  7. ncbi Coordination of locomotion with voluntary movements in humans
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 00179 Rome, Italy
    J Neurosci 25:7238-53. 2005
  8. pmc Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Physiol 577:617-39. 2006
  9. ncbi Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans
    Thomas Hills
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Neurosci 24:1217-25. 2004
  10. ncbi Evidence for a spinal central pattern generator in humans
    M R Dimitrijevic
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 860:360-76. 1998

Research Grants

  1. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2011
  2. mDpy-30, intracellular protein transport, and histone methylation
    DZWOKAI Z MA; Fiscal Year: 2010
  3. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
  4. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
  5. PHENCYCLIDINE: A BEHAVIORAL AND NEUROCHEMICAL STUDY
    Herbert Meltzer; Fiscal Year: 1980
  6. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  8. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
  9. Changing a reflex to improve locomotion
    Aiko Thompson; Fiscal Year: 2010
  10. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010

Detail Information

Publications284 found, 100 shown here

  1. pmc The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span
    Ji Wu Wang
    Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 121:4118-26. 2011
    ..Our results establish that FUS and TDP-43 function together in vivo and suggest that molecular pathways requiring the combined activities of both of these proteins may be disrupted in ALS and FTD...
  2. pmc Patterned control of human locomotion
    Francesco Lacquaniti
    Department of Systems Medicine, Neuroscience Section, University of Rome Tor Vergata, 00133 Rome, Italy
    J Physiol 590:2189-99. 2012
    ..Here we review recent studies on human locomotion showing that muscle activity is accounted for by a combination of few basic patterns, each one timed at a ..
  3. ncbi Restoring voluntary control of locomotion after paralyzing spinal cord injury
    Rubia van den Brand
    Neurology Department, University of Zurich, Ch 8008 Zurich, Switzerland
    Science 336:1182-5. 2012
    ..cortex regained the capacity to transform contextual information into task-specific commands to execute refined locomotion. This recovery relied on the extensive remodeling of cortical projections, including the formation of brainstem ..
  4. pmc Circuits controlling vertebrate locomotion: moving in a new direction
    Martyn Goulding
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:507-18. 2009
    ..The motor circuits in the spinal cord that control locomotion, commonly referred to as central pattern generator networks, provide an experimentally tractable model system ..
  5. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..The emergence of these new functional states enabled full weight-bearing treadmill locomotion in paralyzed rats that was almost indistinguishable from voluntary stepping...
  6. pmc Organization of mammalian locomotor rhythm and pattern generation
    David A McCrea
    Spinal Cord Research Centre and Department of Physiology, University of Manitoba, 730 William Avenue, Winnipeg, Manitoba R3E 3J7, Canada
    Brain Res Rev 57:134-46. 2008
    ..CPGs) located in the spinal cord produce the coordinated activation of flexor and extensor motoneurons during locomotion. Previously proposed architectures for the spinal locomotor CPG have included the classical half-center ..
  7. ncbi Coordination of locomotion with voluntary movements in humans
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 00179 Rome, Italy
    J Neurosci 25:7238-53. 2005
    Muscle activity occurring during human locomotion can be accounted for by five basic temporal activation patterns in a variety of locomotion conditions...
  8. pmc Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    J Physiol 577:617-39. 2006
    ..The model reproduces the range of locomotor periods and phase durations observed during real locomotion in adult cats and permits independent control of the level of motoneurone activity and of step cycle timing...
  9. ncbi Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans
    Thomas Hills
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Neurosci 24:1217-25. 2004
    ..Both GLR-1 and GLR-2 are expressed in the locomotory control circuit that modulates the direction of locomotion in response to sensory stimuli and the duration of forward movement during foraging...
  10. ncbi Evidence for a spinal central pattern generator in humans
    M R Dimitrijevic
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 860:360-76. 1998
    ....
  11. pmc The primate semicircular canal system and locomotion
    Fred Spoor
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:10808-12. 2007
    ..semicircular canal system of vertebrates helps coordinate body movements, including stabilization of gaze during locomotion. Quantitative phylogenetically informed analysis of the radius of curvature of the three semicircular canals in ..
  12. doi Age-related modifications of muscle synergies and spinal cord activity during locomotion
    Vito Monaco
    Advanced Robotics Technology and System Laboratory, Scuola Superiore Sant Anna, Pisa, Italy
    J Neurophysiol 104:2092-102. 2010
    Recent findings have shown that neural circuits located in the spinal cord drive muscular activations during locomotion while intermediating between descending signals and peripheral sensory information...
  13. doi Recovery of locomotion after spinal cord injury: some facts and mechanisms
    Serge Rossignol
    Groupe de Recherche sur le Système Nerveux Central, Department of Physiology, and Multidisciplinary Team in Locomotor Rehabilitation of the Canadian Institutes for Health Research, Universite de Montreal, Montreal H3C 3J7, Canada
    Annu Rev Neurosci 34:413-40. 2011
    ..functions can recover, ranging from simple spinal reflexes to more elaborate motor patterns, such as locomotion. Locomotor recovery after complete spinalization (complete SCI) must depend on the presence of spinal circuitry ..
  14. doi An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion
    Taizo Kawano
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G1X5, Canada
    Neuron 72:572-86. 2011
    ..By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C...
  15. ncbi Significance of load receptor input during locomotion: a review
    V Dietz
    Swiss Paraplegic Centre, University Hospital Balgrist, Forchstr 340, CH 8008, Zurich, Switzerland
    Gait Posture 11:102-10. 2000
    A basic aspect of the neuronal control of quadrupedal locomotion of cat and of bipedal stance and gait of humans concerns the antigravity function of leg extensors...
  16. doi Automated imaging of neuronal activity in freely behaving Caenorhabditis elegans
    Juliette Ben Arous
    Laboratoire de Physique Statistique de l Ecole Normale Superieure, CNRS, UPMC, 24, rue Lhomond, 75005 Paris, France
    J Neurosci Methods 187:229-34. 2010
    ..Caenorhabditis elegans on standard agar plates, we show that spontaneous reversals from forward to backward locomotion reflect precisely the activity of the AVA command interneurons...
  17. ncbi Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1
    Joshua A Ainsley
    Department of Physiology and Biophysics, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Curr Biol 13:1557-63. 2003
    Coordination of rhythmic locomotion depends upon a precisely balanced interplay between central and peripheral control mechanisms...
  18. ncbi Modular control of limb movements during human locomotion
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 27:11149-61. 2007
    ..We explored this idea for human locomotion by examining limb kinematics...
  19. ncbi Biological pattern generation: the cellular and computational logic of networks in motion
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Neuron 52:751-66. 2006
    ..In addition, I will outline the utility of computational models in analysis of the dynamic actions of these motor networks...
  20. ncbi Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening
    Brent Lockwood
    Department of Biopharmaceutical Sciences, Programs in Human Genetics and Biological Sciences, Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, CA 94143 0446, USA
    Pharmacol Biochem Behav 77:647-54. 2004
    ..Therefore, the larval zebrafish represent a tractable vertebrate model system for a large-scale genetic analysis of the biological effects of alcohol...
  21. ncbi Central pattern generators for locomotion control in animals and robots: a review
    Auke Jan Ijspeert
    School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne, Station 14, Lausanne, Switzerland
    Neural Netw 21:642-53. 2008
    The problem of controlling locomotion is an area in which neuroscience and robotics can fruitfully interact. In this article, I will review research carried out on locomotor central pattern generators (CPGs), i.e...
  22. doi Development of human locomotion
    Francesco Lacquaniti
    Department of Systems Medicine, Neuroscience Section, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Opin Neurobiol 22:822-8. 2012
    Neural control of locomotion in human adults involves the generation of a small set of basic patterned commands directed to the leg muscles...
  23. ncbi Plasticity of the spinal neural circuitry after injury
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Annu Rev Neurosci 27:145-67. 2004
    ..Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention...
  24. ncbi Locomotion through apertures when wider space for locomotion is necessary: adaptation to artificially altered bodily states
    Takahiro Higuchi
    Gait and Posture Laboratory, Department of Kinesiology, University of Waterloo, N2L 3G1, Waterloo, ON, Canada
    Exp Brain Res 175:50-9. 2006
    ..In one of four locomotion forms (normal walking, walking while holding a 63-cm horizontal bar with or without rotating the shoulders to ..
  25. doi Real versus imagined locomotion: a [18F]-FDG PET-fMRI comparison
    Christian la Fougere
    Department of Nuclear Medicine, Ludwig Maximilians University of Munich, Germany
    Neuroimage 50:1589-98. 2010
    ..In this study the whole brain activation and deactivation pattern during real locomotion was investigated by [(18)F]-FDG-PET and compared to BOLD-signal changes during imagined locomotion in the same ..
  26. ncbi Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
    ..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving...
  27. ncbi Rehabilitation of locomotion after spinal cord injury
    Hubertus J A van Hedel
    SCI Research, Spinal Cord Injury Center, University of Zurich, Balgrist University Hospital, Forchstrasse 340, Ch 8008 Zurich, Switzerland
    Restor Neurol Neurosci 28:123-34. 2010
    Advances in our understanding of the control of locomotion enable us to optimize the rehabilitation of patients with a spinal cord injury (SCI)...
  28. ncbi How animals move: an integrative view
    M H Dickinson
    Department of Integrative Biology, University of California, Berkeley, CA 94720, USA
    Science 288:100-6. 2000
    Recent advances in integrative studies of locomotion have revealed several general principles. Energy storage and exchange mechanisms discovered in walking and running bipeds apply to multilegged locomotion and even to flying and swimming...
  29. pmc The role of the TRP channel NompC in Drosophila larval and adult locomotion
    Li E Cheng
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 67:373-80. 2010
    ..found that the proper function of NompC, a putative mechanosensitive TRP channel, is not only required for fly locomotion, but also crucial for larval crawling...
  30. ncbi Locomotor-like movements evoked by leg muscle vibration in humans
    V S Gurfinkel
    Laboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia
    Eur J Neurosci 10:1608-12. 1998
    ..between evoked hip and knee movements could be positive or negative, corresponding to 'backward' or 'forward' locomotion. Such an essential feature of natural human locomotion as alternating movements of two legs, was also present in ..
  31. ncbi Patterns of locomotor drive to motoneurons and last-order interneurons: clues to the structure of the CPG
    R E Burke
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4455, USA
    J Neurophysiol 86:447-62. 2001
    ..in several hindlimb motor pools and the modulation of oligosynaptic cutaneous reflex pathways during fictive locomotion in decerebrate unanesthetized cats to assess the notion that such linkages can shed light on the structure of ..
  32. ncbi The ant odometer: stepping on stilts and stumps
    Matthias Wittlinger
    Department of Neurobiology, University of Ulm, D 89069 Ulm, Germany
    Science 312:1965-7. 2006
    ..Travel distance is overestimated by experimental animals walking on stilts and underestimated by animals walking on stumps...
  33. ncbi Sequential activation of muscle synergies during locomotion in the intact cat as revealed by cluster analysis and direct decomposition
    Nedialko Krouchev
    Departement de Physiologie, Universite de Montreal, Centre Ville, Montreal, Quebec, H3C 3J7 Canada
    J Neurophysiol 96:1991-2010. 2006
    During goal-directed locomotion, descending signals from supraspinal structures act through spinal interneuron pathways to effect modifications of muscle activity that are appropriate to the task requirements...
  34. ncbi Goal directed locomotion and balance control in autistic children
    S Vernazza-Martin
    Laboratoire Sport et Culture EA2931, Universite Paris X Nanterre, 200 av de la République, 92001, Nanterre, France
    J Autism Dev Disord 35:91-102. 2005
    This article focuses on postural anticipation and multi-joint coordination during locomotion in healthy and autistic children. Three questions were addressed...
  35. ncbi Visual estimation of spatial requirements for locomotion in novice wheelchair users
    Takahiro Higuchi
    Yokohama National University, Japan
    J Exp Psychol Appl 10:55-66. 2004
    b>Locomotion using a wheelchair requires a wider space than does walking. Two experiments were conducted to test the ability of nonhandicapped adults to estimate the spatial requirements for wheelchair use...
  36. doi Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol
    R C MacPhail
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 30:52-8. 2009
    ..We studied the locomotion of individual zebrafish larva (6 days post-fertilization) in 96-well microtiter plates...
  37. pmc Training locomotor networks
    V Reggie Edgerton
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Brain Res Rev 57:241-54. 2008
    ....
  38. ncbi CatWalk-assisted gait analysis in the assessment of spinal cord injury
    Frank P T Hamers
    Rudolf Magnus Institute of Neuroscience, Department of Oto Rhino Laryngology, Utrecht, The Netherlands
    J Neurotrauma 23:537-48. 2006
    ..Therefore, a major part of this review is devoted to the history and meaning of these coordination measures...
  39. ncbi Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis
    Robert M Brownstone
    Department of Surgery, Faculty of Medicine, Dalhousie University, Canada
    Brain Res Rev 57:64-76. 2008
    ..been barriers to the application of the principles learned to the definition of networks underlying mammalian locomotion. Major difficulties have arisen in identifying spinal interneurones in preparations which allow study of ..
  40. ncbi Neural bases of goal-directed locomotion in vertebrates--an overview
    Sten Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Brain Res Rev 57:2-12. 2008
    The different neural control systems involved in goal-directed vertebrate locomotion are reviewed...
  41. pmc A computational analysis of limb and body dimensions in Tyrannosaurus rex with implications for locomotion, ontogeny, and growth
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom
    PLoS ONE 6:e26037. 2011
    ..of limb muscle sizes as well as the body's centre of mass that could have influenced ontogenetic changes of locomotion in T. rex...
  42. doi On the origin of planar covariation of elevation angles during human locomotion
    Y P Ivanenko
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 99:1890-8. 2008
    ..Recently the role of central versus biomechanical constraints on the kinematics control of human locomotion has been questioned...
  43. ncbi Influences of state anxiety on gaze behavior and stepping accuracy in older adults during adaptive locomotion
    William R Young
    School of Psychology, Queen s University Belfast, Belfast, UK
    J Gerontol B Psychol Sci Soc Sci 67:43-51. 2012
    ..e., looking away from a target box prior to completing the step on it in order to fixate future constraints in the walkway) and (b) reduced stepping accuracy on the target in older adults...
  44. pmc Mild calorie restriction induces fat accumulation in female C57BL/6J mice
    Xingsheng Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 18:456-62. 2010
    ..The increase in fat mass and decrease in lean mass may be a stress response to the uncertainty of food availability...
  45. ncbi Animal navigation: the difficulty of moving in a straight line
    Allen Cheung
    Centre of Excellence in Vision Science, Research School of Biological Sciences, Australian National University, Canberra, ACT, 2601, Australia
    Biol Cybern 97:47-61. 2007
    ..Some specific examples are discussed. An important corollary arising from the analysis of compassless navigation is that the maximum expected displacement represents a robust measure of the straightness of a path...
  46. pmc Some sauropods raised their necks--evidence for high browsing in Euhelopus zdanskyi
    Andreas Christian
    Universität Flensburg, Institut für Biologie und ihre Didaktik, Germany
    Biol Lett 6:823-5. 2010
    ..It is demonstrated for Euhelopus as well as for the much larger Brachiosaurus that despite an increase in the metabolic rate, high browsing was worthwhile for a sauropod if resources were far apart...
  47. ncbi Intrinsic function of a neuronal network - a vertebrate central pattern generator
    S Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res Brain Res Rev 26:184-97. 1998
    ..This is one of the few vertebrate networks that is understood at a cellular level...
  48. ncbi Organizing network action for locomotion: insights from studying insect walking
    Ansgar Buschges
    Department Animal Physiol, Zool Inst, University of Cologne, Weyertal 119, 50923 Cologne, Germany
    Brain Res Rev 57:162-71. 2008
    ..We will place the current knowledge and new results into the broad context gained from other locomotor behaviors and organisms...
  49. doi Neonatal exposure to MK-801, an N-methyl-D-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Sugitani, Toyama, Japan
    Brain Res 1352:223-30. 2010
    ..These findings suggest that transient exposure to MK-801 in the neonatal stage causes exaggerated dopamine transmission and cognitive deficits, particularly in the post-puberty stage...
  50. pmc Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors
    K Fouad
    Centre for Neuroscience, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    J Neurophysiol 104:2975-84. 2010
    ..we investigated the contribution of constitutive 5-HT(2) receptor activity (activity in the absence of 5-HT) to locomotion after SCI...
  51. doi Analysis of a spatial orientation memory in Drosophila
    Kirsa Neuser
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Nature 453:1244-7. 2008
    ..Here we show that Drosophila melanogaster possesses a similar spatial memory during locomotion. Using a new detour setup, we show that flies can remember the position of an object for several seconds after ..
  52. pmc A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: I. Rhythm generation
    Lucy E Spardy
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neural Eng 8:065003. 2011
    b>Locomotion in mammals is controlled by a spinal central pattern generator (CPG) coupled to a biomechanical limb system, with afferent feedback to the spinal circuits and CPG closing the control loop...
  53. pmc High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the "tracker" program
    Nathan C Donelson
    Department of Biology, National Center for Behavioral Genomics and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS ONE 7:e37250. 2012
    ..The interaction of sleep with other behaviors can also be assessed directly in many cases with this method...
  54. ncbi Perception of spatial requirements for wheelchair locomotion in experienced users with tetraplegia
    Takahiro Higuchi
    Department of Health Promotion Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    J Physiol Anthropol 28:15-21. 2009
    This study focused on whether wheelchair users showed enhanced ability to estimate the space required for locomotion with familiar and unfamiliar wheelchairs...
  55. pmc Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization
    Guisheng Zhong
    Department of Neurobiology and Behavior, Cornell University, W 159 Seeley G Mudd Hall, Ithaca, NY 14853, USA
    J Physiol 590:4735-59. 2012
    We explored the organization of the spinal central pattern generator (CPG) for locomotion by analysing the activity of spinal interneurons and motoneurons during spontaneous deletions occurring during fictive locomotion in the isolated ..
  56. pmc Rate-dependent control strategies stabilize limb forces during human locomotion
    Jasper T Yen
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
    J R Soc Interface 7:801-10. 2010
    ..for hopping and running animals and is pervasive throughout experimental and theoretical studies of legged locomotion. Given the neuromechanical complexity of the leg, it remains unclear how joint dynamics are selected to achieve ..
  57. ncbi Thomas Graham Brown (1882--1965), Anders Lundberg (1920-), and the neural control of stepping
    Douglas G Stuart
    Department of Physiology, University of Arizona, AHSC, Tucson, AZ 85724 5051, USA
    Brain Res Rev 59:74-95. 2008
    ..Subsequently, models of the spinal pattern generators for mammalian locomotion have become progressively more complex but they mostly still include a half-center component.
  58. pmc Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
    Caroline Geisler
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Proc Natl Acad Sci U S A 107:7957-62. 2010
    ....
  59. doi The tail of Tyrannosaurus: reassessing the size and locomotive importance of the M. caudofemoralis in non-avian theropods
    W Scott Persons
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Anat Rec (Hoboken) 294:119-31. 2011
    ....
  60. pmc Effects of attention on the control of locomotion in individuals with chronic low back pain
    Claudine J C Lamoth
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Neuroeng Rehabil 5:13. 2008
    ..Conversely, because chronic pain has a strong attentional component, diverting attention away from the pain might facilitate a more efficient walking pattern...
  61. ncbi Neurosurgery: functional regeneration after laser axotomy
    Mehmet Fatih Yanik
    Department of Applied Physics, Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    Nature 432:822. 2004
    ..Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form...
  62. ncbi Early emergence of temporal co-ordination of lower limb segments elevation angles in human locomotion
    G Cheron
    Laboratory of Movement Biomechanics, ISEPK, Universite Libre de Bruxelles, Avenue P Héger, CP168, Brussels B 1050, Belgium
    Neurosci Lett 308:123-7. 2001
    ..Adult-like CCF parameters were reached earlier for alpha(s)-alpha(f) than alpha(t)-alpha(s), indicating disto-proximal maturation of the temporal co-ordination of the lower limb segments in human locomotion.
  63. ncbi Visual and vestibular influences on head-direction cells in the anterior thalamus of the rat
    H T Blair
    Department of Psychology, Yale University, New Haven, Connecticut 06520 8205, USA
    Behav Neurosci 110:643-60. 1996
    ..The authors conclude that vestibular and visual movement cues work interactively, along with visual landmarks and motor signals, to determine the directional frame of reference...
  64. pmc Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
    Kaoru Takakusaki
    Department of Physiology, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa 078 8510, Japan
    J Physiol 568:1003-20. 2005
    ..0 mm, 0.20-0.25 microl) into the MLR reduced the intensity of the electrical stimulation required to induce locomotion on a treadmill (4 cats) or even elicit locomotor movements without electrical stimulation (2 cats)...
  65. pmc A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila
    Eric C Kong
    Ernest Gallo Clinic and Research Center, Emeryville, California, United States of America
    PLoS ONE 5:e9954. 2010
    ..neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated...
  66. ncbi Cerebellar control of balance and locomotion
    Susanne M Morton
    Kennedy Krieger Institute and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroscientist 10:247-59. 2004
    The cerebellum is important for movement control and plays a particularly crucial role in balance and locomotion. As such, one of the most characteristic signs of cerebellar damage is walking ataxia...
  67. ncbi Driven gait orthosis for improvement of locomotor training in paraplegic patients
    G Colombo
    Rehabilitation and Research Institute ParaCare, University Hospital Balgrist, Zurich, Switzerland
    Spinal Cord 39:252-5. 2001
    ..With the driven gait orthosis training sessions can be prolonged and workload of therapists can be reduced, and therefore, the automated training represents an alternative to the conventional therapy...
  68. ncbi Froude and the contribution of naval architecture to our understanding of bipedal locomotion
    Christopher L Vaughan
    MRC UCT Medical Imaging Research Unit, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Western Cape 7925, South Africa
    Gait Posture 21:350-62. 2005
    ..linear dimension (such as leg length), has found widespread application in the biomechanics of bipedal locomotion. This review of two parameters, Fr and dimensionless velocity beta = (Fr)1/2, that have served as the criterion ..
  69. ncbi Dimensional analysis of ADHD subtypes in rats
    Candice Blondeau
    Hôpital Charles Perrens, Laboratoire de Neuropsychobiologie des Desadaptations, Université Victor Segalen Bordeaux 2 CNRS UMR 554 1, Bordeaux, France
    Biol Psychiatry 61:1340-50. 2007
    ..The nature of the biological dysfunction sustaining each subtype (common or distinct) is unknown, and animal models encompassing different subtypes are needed...
  70. doi How might ants use panoramic views for route navigation?
    Andrew Philippides
    School of Informatics, University of Sussex, Falmer, Brighton BN1 9QJ, UK
    J Exp Biol 214:445-51. 2011
    ....
  71. pmc Genetic dissection of theta rhythm heterogeneity in mice
    Jonghan Shin
    Division of Life Sciences, Korea Institute of Science and Technology, Seoul
    Proc Natl Acad Sci U S A 102:18165-70. 2005
    ..The results genetically define the existence of at least two subtypes of theta rhythms and reveal their association with different behaviors...
  72. ncbi A nearly modern amphibious bird from the Early Cretaceous of northwestern China
    Hai Lu You
    Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, People s Republic of China
    Science 312:1640-3. 2006
    ..The anatomy of Gansus, like that of other non-neornithean (nonmodern) ornithuran birds, indicates specialization for an amphibious life-style, supporting the hypothesis that modern birds originated in aquatic or littoral niches...
  73. ncbi Hindlimb muscle function in relation to speed and gait: in vivo patterns of strain and activation in a hip and knee extensor of the rat (Rattus norvegicus)
    G B Gillis
    Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 204:2717-31. 2001
    Understanding how animals actually use their muscles during locomotion is an important goal in the fields of locomotor physiology and biomechanics...
  74. pmc Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
    Jon F Davis
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Behav Neurosci 122:1257-63. 2008
    ....
  75. pmc Genetic dissection of rhythmic motor networks in mice
    Katja S Grossmann
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Prog Brain Res 187:19-37. 2010
    Simple motor behaviors such as locomotion and respiration involve rhythmic and coordinated muscle movements that are generated by central pattern generator (CPG) networks in the spinal cord and hindbrain...
  76. pmc Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics
    Stefan R Pulver
    Brandeis University, Department of Biology, National Center of Behavioral Genomics and Volen Center for Complex Systems, Waltham, Massachusetts, USA
    Nat Neurosci 13:53-9. 2010
    ..This current also interacted with endogenous Shal K(+) conductances to modulate spike timing for multiple seconds following rhythmic activity, providing a cellular memory of network activity on a behaviorally relevant timescale...
  77. ncbi The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm
    Sabrina Tazerart
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Universite Aix Marseille, F 13402 Marseille Cedex 20, France
    J Neurosci 28:8577-89. 2008
    ..Little is known about the contribution of the latter mechanisms to the integrated network activity underlying locomotion in mammals...
  78. pmc Bipedal locomotion in crawling cells
    Erin L Barnhart
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Biophys J 98:933-42. 2010
    ..These results demonstrate that simple elastic coupling between movement at the front of the cell and movement at the rear can generate large-scale mechanical integration of cell behavior...
  79. doi Head shape evolution in Tropidurinae lizards: does locomotion constrain diet?
    T Kohlsdorf
    Department of Biology, FFCLRP University of São Paulo, Ribeirao Preto, SP, Brazil
    J Evol Biol 21:781-90. 2008
    ..examples of a complex system with several possible functions, being associated to activities as different as locomotion, prey capture, display and defensive behaviours...
  80. ncbi Assessment of speed and position during human locomotion using nondifferential GPS
    Andrew D Townshend
    Institute of Health and Biomedical Innovation and School of Human Movement Studies, Queensland University of Technology, Queensland, Australia
    Med Sci Sports Exerc 40:124-32. 2008
    To validate a nondifferential global positioning system (GPS) to measure speed, displacement, and position during human locomotion.
  81. ncbi Basal ganglia neural responses during behaviorally effective deep brain stimulation of the subthalamic nucleus in rats performing a treadmill locomotion test
    Li Hong Shi
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 59:445-57. 2006
    ..medial forebrain bundle and subsequently developed a partial akinesia, which was assessed during the treadmill locomotion task. High frequency stimulation (HFS) of the STN restored normal treadmill locomotion behavior...
  82. ncbi From swimming to walking with a salamander robot driven by a spinal cord model
    Auke Jan Ijspeert
    School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Station 14, CH 1015 Lausanne, Switzerland
    Science 315:1416-20. 2007
    The transition from aquatic to terrestrial locomotion was a key development in vertebrate evolution...
  83. pmc Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors
    Ryan M Drenan
    California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 30:9877-89. 2010
    ..These results implicate alpha6alpha4beta2* nAChRs in cholinergic control of DA transmission, and strongly suggest that these receptors are candidate drug targets for disorders involving the DA system...
  84. ncbi Stance- and locomotion-dependent processing of vibration-induced proprioceptive inflow from multiple muscles in humans
    Gregoire Courtine
    Dipartamento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita di Pavia, Pavia, Italy
    J Neurophysiol 97:772-9. 2007
    ....
  85. ncbi An evaluation of sensorimotor integration during locomotion toward a target in Parkinson's disease
    Q J Almeida
    Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, 75 University Avenue West, Waterloo, Ontario, Canada N2L 3C5
    Neuroscience 134:283-93. 2005
    ..We evaluated dopaminergic system involvement in this sensorimotor process during locomotion within a large sample of Parkinson's disease (PD) patients while "On" and "Off" their dopaminergic medications (..
  86. doi The evolutionary continuum of limb function from early theropods to birds
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL9 7TA, UK
    Naturwissenschaften 96:423-48. 2009
    ....
  87. ncbi Neurons regulating the duration of forward locomotion in Caenorhabditis elegans
    Tokumitsu Wakabayashi
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4 3 5 Ueda, Morioka 020 8551, Japan
    Neurosci Res 50:103-11. 2004
    ..To gain insight into the neuronal mechanisms regulating this locomotion, we analyzed the locomotory behavior of C. elegans over a long time period...
  88. ncbi Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    Hans S Keirstead
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, College of Medicine, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurosci 25:4694-705. 2005
    ..These studies document the feasibility of predifferentiating hESCs into functional OPCs and demonstrate their therapeutic potential at early time points after spinal cord injury...
  89. doi Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
    Helena A D Johard
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Comp Neurol 516:59-73. 2009
    ..Our findings emphasize that the LN(d)s are heterogeneous both anatomically and with respect to content of neuropeptides, cryptochrome, and other markers and suggest diverse functions of these neurons...
  90. ncbi Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase A
    M A Sutton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 11:365-76. 2000
    ..drug-free 60 min session, animals that received amphetamine/environment pairings demonstrated conditioned locomotion relative to controls...
  91. ncbi Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion
    David L McLean
    School of Biology, Division of Biomedical Sciences, University of St Andrews, St Andrews, Fife KY16 9TS, United Kingdom
    J Neurosci 22:4175-84. 2002
    ..The presynaptic and postsynaptic effects of NO act in concert to tune inhibitory synapses...
  92. pmc Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion
    Shawnna M Buttery
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Mol Biol Cell 14:5082-8. 2003
    ..cytosolic proteins that orchestrate the site-specific assembly and bundling of MSP filaments that generates locomotion. Here, we identify a fraction of cytosol that is comprised of a small number of proteins but contains all of the ..
  93. ncbi A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor
    S C Fowler
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, USA
    J Neurosci Methods 107:107-24. 2001
    ..Finally, potential applications in neuroscience research other than those illustrated in this report were discussed...
  94. doi Forelimb indicators of prey-size preference in the Felidae
    Julie Meachen-Samuels
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA
    J Morphol 270:729-44. 2009
    ..we found that felids and canids differ in forelimb scaling, which emphasizes the dual use of forelimbs for locomotion and prey capture in felids...
  95. pmc UNC-1 regulates gap junctions important to locomotion in C. elegans
    Bojun Chen
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030
    Curr Biol 17:1334-9. 2007
    ..elegans, loss-of-function (lf) mutations of the stomatin-like protein (SLP) UNC-1 and the innexin UNC-9 inhibit locomotion [1, 2] and modulate sensitivity to volatile anesthetics [3, 4]...
  96. ncbi The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans
    Marcus Guest
    School of Biological Sciences, Bassett Crescent East, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:1577-88. 2007
    ..has pleiotropic effects on the behaviour of the model genetic animal Caenorhabditis elegans: it inhibits locomotion, feeding, egg-laying and slows development...
  97. ncbi Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion
    Martin Hägglund
    Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nat Neurosci 13:246-52. 2010
    Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating ..
  98. pmc Large-scale association study for structural soundness and leg locomotion traits in the pig
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 41:14. 2009
    ..Few candidate genes related to soundness traits have been identified in the pig...
  99. ncbi Marching to the beat of the same drummer: the spontaneous tempo of human locomotion
    Hamish G Macdougall
    Mount Sinai School of Medicine, Dept of Neurology, Human Aerospace Laboratory, New York, NY 10029, USA
    J Appl Physiol 99:1164-73. 2005
    ..path or on a treadmill, and whether such a highly tuned frequency of movement can be generalized to all forms of locomotion in a natural setting is unknown...
  100. ncbi The locomotor kinematics of Asian and African elephants: changes with speed and size
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL9 7TA, UK
    J Exp Biol 209:3812-27. 2006
    For centuries, elephant locomotion has been a contentious and confusing challenge for locomotion scientists to understand, not only because of technical difficulties but also because elephant locomotion is in some ways atypical of more ..
  101. ncbi Red nucleus lesions impair overground locomotion in rats: a kinetic analysis
    G D Muir
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Eur J Neurosci 12:1113-22. 2000
    ..these structures might also be involved in control of more general limb actions, such as those occurring during locomotion. The present study investigates this question by measuring the three-dimensional ground reaction forces produced ..

Research Grants91

  1. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2011
    ..The biomechanics of locomotion are better defined in cats and cats have a hindlimb gait that is close to human than is the rat...
  2. mDpy-30, intracellular protein transport, and histone methylation
    DZWOKAI Z MA; Fiscal Year: 2010
    ..Cell movement is a process fundamental to the viability of organisms. In simple organisms, cell locomotion primarily functions in mating and food searching behaviors...
  3. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
    ..Although tizanidine has been used to treat spasticity, and the LOKOMAT to improve locomotion, there have been no prior attempts to characterize the interactions between these therapies...
  4. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
    ..Although tizanidine has been used to treat spasticity, and the LOKOMAT to improve locomotion, there have been no prior attempts to characterize the interactions between these therapies...
  5. PHENCYCLIDINE: A BEHAVIORAL AND NEUROCHEMICAL STUDY
    Herbert Meltzer; Fiscal Year: 1980
    ..PCP (0-15mg/kg, i.pp)-induced locomotion approximated an inverted U-shaped function for 30 min after administration but between 60-90 min locomotion was ..
  6. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..for H-reflex change;that cerebellar output to SMC is essential;and that H-reflex conditioning affects locomotion and can improve it after spinal cord injury...
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..for H-reflex change;that cerebellar output to SMC is essential;and that H-reflex conditioning affects locomotion and can improve it after spinal cord injury...
  8. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..This will also be used in human locomotion experiments. 6...
  9. Changing a reflex to improve locomotion
    Aiko Thompson; Fiscal Year: 2010
    ..The goal of this project is to investigate the impact of changing a spinal reflex on impaired locomotion after chronic incomplete SCI in people...
  10. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..is to delineate the impact of chemically induced oxidative stress on genetic networks that are associated with locomotion phenotypes...
  11. Oxidative stress and neurogenetic networks in Drosophila
    ROBERT ANHOLT; Fiscal Year: 2009
    ..is to delineate the impact of chemically induced oxidative stress on genetic networks that are associated with locomotion phenotypes...
  12. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..leg spring" represents the spring-like characteristics of the overall integrated musculoskeletal system during locomotion, and the mass is equivalent to the mass of the animal...
  13. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..is for SBIR Phase I research to determine the design and feasibility of an innovative, new device for advanced locomotion analysis including: ambulation assessment and fall prevention, postural perturbation assessment and activity ..
  14. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 1999
    ..leg spring" represents the spring-like characteristics of the overall integrated musculoskeletal system during locomotion, and the mass is equivalent to the mass of the animal...
  15. MUSCULOSKELETAL STIFFNESS AND LOCOMOTION
    CLAIRE FARLEY; Fiscal Year: 2000
    ..leg spring" represents the spring-like characteristics of the overall integrated musculoskeletal system during locomotion, and the mass is equivalent to the mass of the animal...
  16. Spinal Reflex Conditioning and Locomotion
    JONATHAN RICKEL contact WOLPAW; Fiscal Year: 2010
    ..Recent work shows that soleus H-reflex conditioning changes soleus behavior during locomotion, and suggests that appropriate conditioning can improve locomotion after a spinal cord injury...
  17. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
    ..Recent work shows that soleus H-reflex conditioning changes soleus behavior during locomotion, and suggests that appropriate conditioning can improve locomotion after a spinal cord injury...
  18. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
    ..Recent work shows that soleus H-reflex conditioning changes soleus behavior during locomotion, and suggests that appropriate conditioning can improve locomotion after a spinal cord injury...
  19. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2009
    ..disparity between transfemoral amputees and healthy persons during level walking, and by enabling forms of locomotion, such as ramp and stair climbing, not presently afforded by state-of-the-art devices...
  20. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2007
    ..disparity between transfemoral amputees and healthy persons during level walking, and by enabling forms of locomotion, such as ramp and stair climbing, not presently afforded by state-of-the-art devices...
  21. Task space control of normal & pathological locomotion
    CHENG YUN KAREN LIU; Fiscal Year: 2010
    ..Extensive research has detailed joint kinematics and kinetics of human locomotion and movement control with normal and various motor function disorders...
  22. Biological Motion Perception in Parkinson's Disease
    Abhishek Jaywant; Fiscal Year: 2012
    ..disease (PD) is a neurodegenerative disorder that leads to deficits in both visual perception and locomotion. Research to date has neglected to determine whether PD affects the perception of a unique and important visual ..
  23. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2003
    ..progression with locomotor recovery, as defined by a battery of neurologic tests that evaluate coordinated locomotion, hind limb paw position during locomotion, and performance on an inclined grid...
  24. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..progression with locomotor recovery, as defined by a battery of neurologic tests that evaluate coordinated locomotion, hind limb paw position during locomotion, and performance on an inclined grid...
  25. Signals Regulating Vestibular Endolymph Homeostasis
    Mark Henkemeyer; Fiscal Year: 2004
    ..Preliminary studies show that adult mice mutant for the EphB2 receptor tyrosine kinase display a circling locomotion consistent with a defect in vestibular function...
  26. Signals Regulating Vestibular Endolymph Homeostasis
    Mark Henkemeyer; Fiscal Year: 2005
    ..Preliminary studies show that adult mice mutant for the EphB2 receptor tyrosine kinase display a circling locomotion consistent with a defect in vestibular function...
  27. Signals Regulating Vestibular Endolymph Homeostasis
    Mark Henkemeyer; Fiscal Year: 2003
    ..Preliminary studies show that adult mice mutant for the EphB2 receptor tyrosine kinase display a circling locomotion consistent with a defect in vestibular function...
  28. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory Goldberg; Fiscal Year: 2009
    ..These findings have profound implications for a mechanistic understanding of the role of MMPs in cell locomotion in a collagen rich microenvironment. We thus propose a model for a Mobile Cell Surface Collagenolytic Interface...
  29. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory I Goldberg; Fiscal Year: 2010
    ..These findings have profound implications for a mechanistic understanding of the role of MMPs in cell locomotion in a collagen rich microenvironment. We thus propose a model for a Mobile Cell Surface Collagenolytic Interface...
  30. Elastic mechanisms in locomotion
    Thomas Roberts; Fiscal Year: 2009
    ..contractile elements can significantly influence the force, power and displacement of muscle fibers during locomotion. All movements involve dynamic interaction between passive elastic structures and muscle contractile elements, ..
  31. Elastic mechanisms in locomotion
    THOMAS JAY ROBERTS; Fiscal Year: 2010
    ..contractile elements can significantly influence the force, power and displacement of muscle fibers during locomotion. All movements involve dynamic interaction between passive elastic structures and muscle contractile elements, ..
  32. CHILD MOBILITY: ROLE OF STRENGTH, BODY FAT & ENERGY COST
    CRAIG MC DONALD; Fiscal Year: 2000
    ..this study focuses on strength and body fat as determinants of energy cost of ambulation and wheelchair locomotion in children with variable degrees of mobility impairment due to myelomeningocele (MM), spinal cord injury (SCI), ..
  33. CHILD MOBILITY: ROLE OF STRENGTH, BODY FAT & ENERGY COST
    CRAIG MC DONALD; Fiscal Year: 1999
    ..this study focuses on strength and body fat as determinants of energy cost of ambulation and wheelchair locomotion in children with variable degrees of mobility impairment due to myelomeningocele (MM), spinal cord injury (SCI), ..
  34. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew A Biewener; Fiscal Year: 2010
    ..that: (a) differential patterns of motor recruitment (between the fast and slow units) occur during goat locomotion, and (b) the faster motor units are preferentially activated, relative to slow units, for tasks that require ..
  35. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew Biewener; Fiscal Year: 2009
    ..that: (a) differential patterns of motor recruitment (between the fast and slow units) occur during goat locomotion, and (b) the faster motor units are preferentially activated, relative to slow units, for tasks that require ..
  36. FUNCTIONAL REGENERATION OF LOCOMOTOR COMMAND NEURONS
    ANDREW MCCLELLAN; Fiscal Year: 1991
    In normal lampreys some of the brainstem command neurons which initiate locomotion are reticulospinal (RS) neurons in the medial and posterior rhombencephalic reticular nuclei (MRRN and PRRN) that have descending axons in the latcral ..
  37. IMMUNOSUPPRESSION IN CANCER PATIENTS
    Arthur Bankhurst; Fiscal Year: 1990
    ..In this proposal we will examine how mevalonate (MVA) and its metabolites regulate human NK cytotoxicity and locomotion. MVA is the product of 3-hydroxy-3-methyglutaryl Coenzyme A (HMG CoA) reductase, the major regulatory enzyme of ..
  38. CRCNS: Role of sensory feedback in locomotor recovery after spinal cord injury
    Michel A Lemay; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Afferent feedback plays a critical role in the control of locomotion and in the recovery afforded by body-weight supported treadmill training or graft of neurotrophin producing cellular transplants ..
  39. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    REGGIE EDGERTON; Fiscal Year: 2010
    ..This technology has the potential to significantly improve the recovery of posture and locomotion in individuals with a severe spinal cord injury...
  40. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    V Edgerton; Fiscal Year: 2009
    ..This technology has the potential to significantly improve the recovery of posture and locomotion in individuals with a severe spinal cord injury...
  41. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    V Edgerton; Fiscal Year: 2009
    ..This technology has the potential to significantly improve the recovery of posture and locomotion in individuals with a severe spinal cord injury...
  42. Prone Locomotion in Infants with or at Risk for Disabilities
    HLAPANG A KOLOBE; Fiscal Year: 2010
    ..CP is the most disabling condition for children in the United States with locomotion being the most affected functional skill...
  43. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2006
    ..All of these observations indicate that the interneuronal network in lumbar spinal cord can carry out locomotion after SCI, if it can be activated properly...
  44. Identifying transcription factors expressed by ventral spinal cord interneurons
    KATHARINE EMMA LEWIS; Fiscal Year: 2011
    ..specifically focuses on five distinct types of neurons that are located in the ventral spinal cord and regulate locomotion. Despite the importance of these neurons, very little is known about how they develop their functional ..
  45. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2007
    ..All of these observations indicate that the interneuronal network in lumbar spinal cord can carry out locomotion after SCI, if it can be activated properly...
  46. BIOCHEMICAL CORRELATES OF DRUG ABUSE VULNERABILITY
    CHARLES BRADBERRY; Fiscal Year: 1992
    ..expand upon recent findings which demonstrate that certain behavioral measures (novelty-and amphetamine-induced locomotion) predict the amount of amphetamine self-administered by animals...
  47. Re-training locomotor circuitry in a rat model of SCI
    DAVID MAGNUSON; Fiscal Year: 2006
    ..therapy seeks to re-train the spinal cord circuitry below the level of injury to participate in functional locomotion. The mammalian spinal cord, humans included, contains complex neuronal circuitry that participates in the ..
  48. Re-training locomotor circuitry in a rat model of Spinal Cord Injury
    DAVID MAGNUSON; Fiscal Year: 2007
    ..therapy seeks to re-train the spinal cord circuitry below the level of injury to participate in functional locomotion. The mammalian spinal cord, humans included, contains complex neuronal circuitry that participates in the ..
  49. Central Modulation of Rhythms
    Edgar Garcia Rill; Fiscal Year: 2009
    The pedunculopontine nucleus (PPN) helps control sleep-wake rhythms and modulates posture and locomotion. The proposed research will address three functional aspects (ascending, local and descending) of the PPN, the cholinergic arm of ..
  50. Central Modulation of Rhythms
    EDGAR E GARCIA RILL; Fiscal Year: 2010
    The pedunculopontine nucleus (PPN) helps control sleep-wake rhythms and modulates posture and locomotion. The proposed research will address three functional aspects (ascending, local and descending) of the PPN, the cholinergic arm of ..
  51. OCULOMOTOR SYSTEM AND BODY POSTURAL MECHANISMS
    Bernard Cohen; Fiscal Year: 2003
    In this study, monkeys will be used to study vestibular control of locomotion. Compensatory and orienting components of the vestibulo-ocular and vestibular-cervical reflexes arising in the otolith organs and semicircular canals that are ..
  52. FUNCTIONAL REGENERATION OF LOCOMOTOR COMMAND NEURONS
    ANDREW MCCLELLAN; Fiscal Year: 1993
    In normal lampreys some of the brainstem command neurons which initiate locomotion are reticulospinal (RS) neurons in the medial and posterior rhombencephalic reticular nuclei (MRRN and PRRN) that have descending axons in the latcral ..
  53. FUNCTIONAL REGENERATION OF LOCOMOTOR COMMAND NEURONS
    ANDREW MCCLELLAN; Fiscal Year: 1992
    In normal lampreys some of the brainstem command neurons which initiate locomotion are reticulospinal (RS) neurons in the medial and posterior rhombencephalic reticular nuclei (MRRN and PRRN) that have descending axons in the latcral ..
  54. Mechanical Plasticity in Locomotion with Age
    PAUL DE VITA; Fiscal Year: 2006
    ..plasticity emphasizing proximal muscles as a compensatory mechanism for reduced distal muscle function in locomotion. Pilot data show that while walking at the same speed, healthy old vs...
  55. FUNCTION AND REGULATION OF THE HUMAN ARP2/3 COMPLEX
    Matthew D Welch; Fiscal Year: 2010
    ..provided by applicant): The actin cytoskeleton plays an essential role in basic cellular processes including locomotion, membrane transport, and cytokinesis...
  56. Mechanical Plasticity in Locomotion with Age
    PAUL DE VITA; Fiscal Year: 2005
    ..plasticity emphasizing proximal muscles as a compensatory mechanism for reduced distal muscle function in locomotion. Pilot data show that while walking at the same speed, healthy old vs...
  57. FUNCTION AND REGULATION OF THE HUMAN ARP2/3 COMPLEX
    Matthew Welch; Fiscal Year: 2009
    ..provided by applicant): The actin cytoskeleton plays an essential role in basic cellular processes including locomotion, membrane transport, and cytokinesis...
  58. Mechanical Plasticity in Locomotion with Age
    PAUL DE VITA; Fiscal Year: 2007
    ..plasticity emphasizing proximal muscles as a compensatory mechanism for reduced distal muscle function in locomotion. Pilot data show that while walking at the same speed, healthy old vs...
  59. Galanin-opiate interactions
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We have found that galanin knockout mice show increased morphine-induced locomotion and conditioned place preference (CPP), and that these behavioral phenotypes are correlated with increased ..
  60. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2010
    ..We have found that galanin knockout mice show increased morphine-induced locomotion and conditioned place preference (CPP), and that these behavioral phenotypes are correlated with increased ..
  61. MUSCLE FUNCTION DURING TERRESTRIAL LOCOMOTION
    DONALD HOYT; Fiscal Year: 2001
    ..locomotory mechanics to the rate of energy consumption states that the muscles supporting the body during locomotion function isometrically, generating force without shortening...
  62. ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS
    Thomas Andriacchi; Fiscal Year: 2003
    ..Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion ..
  63. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2002
    ..Some animal and clinical studies indicate that muscle activation patterns during locomotion are hardwired into the nervous system and incapable of substantial modification...
  64. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2004
    ..Some animal and clinical studies indicate that muscle activation patterns during locomotion are hardwired into the nervous system and incapable of substantial modification...
  65. ANALYSIS OF THE RECURRENT RENSHAW CIRCUIT
    THOMAS HAMM; Fiscal Year: 1993
    ..activity across motoneuron pools that receive common commands during centrally generated activities like locomotion and scratching...
  66. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2005
    ..Some animal and clinical studies indicate that muscle activation patterns during locomotion are hardwired into the nervous system and incapable of substantial modification...
  67. Unintended muscle activity influences on post-stroke locomotion
    CITLALI LOPEZ ORTIZ; Fiscal Year: 2007
    ..Our lab has shown that there is inappropriate coordination of muscle activity in post-stroke locomotion and that the reaction force against the supporting surface is compromised, in both magnitude and direction...
  68. NEUTROPHIL MOVEMENT--CELLULAR AND MOLECULAR CONTROL
    Thomas Howard; Fiscal Year: 1990
    ..This emigration requires both locomotion and shape change by neutrophils...
  69. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2003
    ..Some animal and clinical studies indicate that muscle activation patterns during locomotion are hardwired into the nervous system and incapable of substantial modification...
  70. AMPHETAMINE-INDUCED STEREOTYPIC LOCOMOTION IN RATS
    KATHYRNE MUELLER; Fiscal Year: 1992
    ..Locomotor stereotypy is defined as repetition of a pattern of locomotion in an open field; that is, the rat frequently retraces its steps...
  71. ROLE OF HYALURONAN IN TUMOR CELL LOCOMOTION
    Eva Turley; Fiscal Year: 1991
    Cell locomotion is a property, inherent to eukaryotic cells, that is critical to the development, homeostasis, repair and disease processes of multicellular organisms...
  72. LOCOMOTION--IDLING METABOLISM AND GAIT DYNAMICS
    C Taylor; Fiscal Year: 1990
    ..determine the manner in which muscles and populations of fibers within muscles are recruited and utilized during locomotion as animals increase speed and change gaits...
  73. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2007
    ..project is to identify the neural circuit that is responsible for the generation of light-elicited ciliary locomotion and reflex-elicited foot contraction; and to understand how Pavlovian conditioning changes synaptic connections ..
  74. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2005
    ..project is to identify the neural circuit that is responsible for the generation of light-elicited ciliary locomotion and reflex-elicited foot contraction; and to understand how Pavlovian conditioning changes synaptic connections ..
  75. CRCNS: Organization of the locomotor CPG in the rodent spinal cord
    Ilya A Rybak; Fiscal Year: 2012
    ..Generator (CPG) neural circuits in the mammalian spinal cord that coordinate rhythmic neural activity driving locomotion. This study will take a general approach that utilizes various spontaneous and evoked perturbations in the ..
  76. ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS
    Thomas Andriacchi; Fiscal Year: 2004
    ..Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion ..
  77. ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS
    Thomas Andriacchi; Fiscal Year: 2002
    ..Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion ..
  78. Psychostimulants and Alpha-1 Adrenoceptor Subtypes
    Paul Wellman; Fiscal Year: 2005
    Psychostimulant-induced changes in locomotion involve activation of the 1B subtype of the a 1 -adrenoceptor (a 1B-AR)...
  79. CENTRAL MODULATION OF LOCOMOTOR RHYTHMS
    Edgar Garcia Rill; Fiscal Year: 1991
    ..region (MLR) is known to initiate and maintain walking in the brainstem- transected animal by modulating locomotion oscillators present in the spinal cord...
  80. CELL SPECIFIC DIFFERENCE IN PHOSPHORYLATION OF K CNANNEL
    Deborah Baro; Fiscal Year: 2000
    ..must plan and execute each step; something must establish the pattern of muscle contraction necessary for locomotion. That "something" is a central pattern generator (CPG)...
  81. ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS
    Thomas Andriacchi; Fiscal Year: 2001
    ..Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion ..
  82. CELL SPECIFIC DIFFERENCE IN PHOSPHORYLATION OF K CNANNEL
    Deborah Baro; Fiscal Year: 2001
    ..must plan and execute each step; something must establish the pattern of muscle contraction necessary for locomotion. That "something" is a central pattern generator (CPG)...
  83. Psychostimulants and Alpha-1 Adrenoceptor Subtypes
    Paul Wellman; Fiscal Year: 2006
    Psychostimulant-induced changes in locomotion involve activation of the 1B subtype of the a 1 -adrenoceptor (a 1B-AR)...