locomotion

Summary

Summary: Movement or the ability to move from one place or another. It can refer to humans, vertebrate or invertebrate animals, and microorganisms.

Top Publications

  1. ncbi The role of the TRP channel NompC in Drosophila larval and adult locomotion
    Li E Cheng
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 67:373-80. 2010
  2. ncbi Neural bases of goal-directed locomotion in vertebrates--an overview
    Sten Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Brain Res Rev 57:2-12. 2008
  3. ncbi Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
    Caroline Geisler
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Proc Natl Acad Sci U S A 107:7957-62. 2010
  4. ncbi The tail of Tyrannosaurus: reassessing the size and locomotive importance of the M. caudofemoralis in non-avian theropods
    W Scott Persons
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Anat Rec (Hoboken) 294:119-31. 2011
  5. ncbi Neurosurgery: functional regeneration after laser axotomy
    Mehmet Fatih Yanik
    Department of Applied Physics, Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    Nature 432:822. 2004
  6. ncbi Effects of attention on the control of locomotion in individuals with chronic low back pain
    Claudine J C Lamoth
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Neuroeng Rehabil 5:13. 2008
  7. ncbi Central pattern generators for locomotion control in animals and robots: a review
    Auke Jan Ijspeert
    School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne, Station 14, Lausanne, Switzerland
    Neural Netw 21:642-53. 2008
  8. ncbi Dimensional analysis of ADHD subtypes in rats
    Candice Blondeau
    Hôpital Charles Perrens, Laboratoire de Neuropsychobiologie des Desadaptations, Université Victor Segalen Bordeaux 2 CNRS UMR 554 1, Bordeaux, France
    Biol Psychiatry 61:1340-50. 2007
  9. ncbi A nearly modern amphibious bird from the Early Cretaceous of northwestern China
    Hai-Lu You
    Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, People's Republic of China
    Science 312:1640-3. 2006
  10. ncbi Hindlimb muscle function in relation to speed and gait: in vivo patterns of strain and activation in a hip and knee extensor of the rat (Rattus norvegicus)
    G B Gillis
    Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 204:2717-31. 2001

Research Grants

  1. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
  2. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
  3. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  4. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  5. Changing a reflex to improve locomotion
    Aiko Thompson; Fiscal Year: 2010
  6. Spinal Reflex Conditioning and Locomotion
    JONATHAN RICKEL contact WOLPAW; Fiscal Year: 2010
  7. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
  8. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
  9. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2007
  10. Task space control of normal & pathological locomotion
    CHENG YUN KAREN LIU; Fiscal Year: 2010

Detail Information

Publications226 found, 100 shown here

  1. ncbi The role of the TRP channel NompC in Drosophila larval and adult locomotion
    Li E Cheng
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 67:373-80. 2010
    ..found that the proper function of NompC, a putative mechanosensitive TRP channel, is not only required for fly locomotion, but also crucial for larval crawling...
  2. ncbi Neural bases of goal-directed locomotion in vertebrates--an overview
    Sten Grillner
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Brain Res Rev 57:2-12. 2008
    The different neural control systems involved in goal-directed vertebrate locomotion are reviewed...
  3. ncbi Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
    Caroline Geisler
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Proc Natl Acad Sci U S A 107:7957-62. 2010
    ....
  4. ncbi The tail of Tyrannosaurus: reassessing the size and locomotive importance of the M. caudofemoralis in non-avian theropods
    W Scott Persons
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Anat Rec (Hoboken) 294:119-31. 2011
    ....
  5. ncbi Neurosurgery: functional regeneration after laser axotomy
    Mehmet Fatih Yanik
    Department of Applied Physics, Ginzton Laboratory, Stanford University, Stanford, California 94305, USA
    Nature 432:822. 2004
    ..Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form...
  6. ncbi Effects of attention on the control of locomotion in individuals with chronic low back pain
    Claudine J C Lamoth
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands
    J Neuroeng Rehabil 5:13. 2008
    ..Conversely, because chronic pain has a strong attentional component, diverting attention away from the pain might facilitate a more efficient walking pattern...
  7. ncbi Central pattern generators for locomotion control in animals and robots: a review
    Auke Jan Ijspeert
    School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne, Station 14, Lausanne, Switzerland
    Neural Netw 21:642-53. 2008
    The problem of controlling locomotion is an area in which neuroscience and robotics can fruitfully interact. In this article, I will review research carried out on locomotor central pattern generators (CPGs), i.e...
  8. ncbi Dimensional analysis of ADHD subtypes in rats
    Candice Blondeau
    Hôpital Charles Perrens, Laboratoire de Neuropsychobiologie des Desadaptations, Université Victor Segalen Bordeaux 2 CNRS UMR 554 1, Bordeaux, France
    Biol Psychiatry 61:1340-50. 2007
    ..The nature of the biological dysfunction sustaining each subtype (common or distinct) is unknown, and animal models encompassing different subtypes are needed...
  9. ncbi A nearly modern amphibious bird from the Early Cretaceous of northwestern China
    Hai-Lu You
    Institute of Geology, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Road, Beijing 100037, People's Republic of China
    Science 312:1640-3. 2006
    ..The anatomy of Gansus, like that of other non-neornithean (nonmodern) ornithuran birds, indicates specialization for an amphibious life-style, supporting the hypothesis that modern birds originated in aquatic or littoral niches...
  10. ncbi Hindlimb muscle function in relation to speed and gait: in vivo patterns of strain and activation in a hip and knee extensor of the rat (Rattus norvegicus)
    G B Gillis
    Department of Organismic and Evolutionary Biology, Harvard University, Concord Field Station, Old Causeway Road, Bedford, MA 01730, USA
    J Exp Biol 204:2717-31. 2001
    Understanding how animals actually use their muscles during locomotion is an important goal in the fields of locomotor physiology and biomechanics...
  11. ncbi Genetic dissection of theta rhythm heterogeneity in mice
    Jonghan Shin
    Division of Life Sciences, Korea Institute of Science and Technology, Seoul
    Proc Natl Acad Sci U S A 102:18165-70. 2005
    ..The results genetically define the existence of at least two subtypes of theta rhythms and reveal their association with different behaviors...
  12. ncbi Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat
    Jon F Davis
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA
    Behav Neurosci 122:1257-63. 2008
    ....
  13. ncbi How might ants use panoramic views for route navigation?
    Andrew Philippides
    School of Informatics, University of Sussex, Falmer, Brighton BN1 9QJ, UK
    J Exp Biol 214:445-51. 2011
    ....
  14. ncbi Head shape evolution in Tropidurinae lizards: does locomotion constrain diet?
    T Kohlsdorf
    Department of Biology, FFCLRP University of São Paulo, Ribeirao Preto, SP, Brazil
    J Evol Biol 21:781-90. 2008
    ..examples of a complex system with several possible functions, being associated to activities as different as locomotion, prey capture, display and defensive behaviours...
  15. ncbi An evaluation of sensorimotor integration during locomotion toward a target in Parkinson's disease
    Q J Almeida
    Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University, 75 University Avenue West, Waterloo, Ontario, Canada N2L 3C5
    Neuroscience 134:283-93. 2005
    ..We evaluated dopaminergic system involvement in this sensorimotor process during locomotion within a large sample of Parkinson's disease (PD) patients while "On" and "Off" their ..
  16. ncbi Stance- and locomotion-dependent processing of vibration-induced proprioceptive inflow from multiple muscles in humans
    Gregoire Courtine
    Dipartamento di Medicina Sperimentale, Sezione di Fisiologia Umana, Universita di Pavia, Pavia, Italy
    J Neurophysiol 97:772-9. 2007
    ....
  17. ncbi From swimming to walking with a salamander robot driven by a spinal cord model
    Auke Jan Ijspeert
    School of Computer and Communication Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Station 14, CH 1015 Lausanne, Switzerland
    Science 315:1416-20. 2007
    The transition from aquatic to terrestrial locomotion was a key development in vertebrate evolution...
  18. ncbi Basal ganglia neural responses during behaviorally effective deep brain stimulation of the subthalamic nucleus in rats performing a treadmill locomotion test
    Li-Hong Shi
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Synapse 59:445-57. 2006
    ..medial forebrain bundle and subsequently developed a partial akinesia, which was assessed during the treadmill locomotion task. High frequency stimulation (HFS) of the STN restored normal treadmill locomotion behavior...
  19. ncbi The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm
    Sabrina Tazerart
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Universite Aix Marseille, F 13402 Marseille Cedex 20, France
    J Neurosci 28:8577-89. 2008
    ..Little is known about the contribution of the latter mechanisms to the integrated network activity underlying locomotion in mammals...
  20. ncbi Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol
    R C MacPhail
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 30:52-8. 2009
    ..We studied the locomotion of individual zebrafish larva (6 days post-fertilization) in 96-well microtiter plates...
  21. ncbi Assessment of speed and position during human locomotion using nondifferential GPS
    Andrew D Townshend
    Institute of Health and Biomedical Innovation and School of Human Movement Studies, Queensland University of Technology, Queensland, Australia
    Med Sci Sports Exerc 40:124-32. 2008
    To validate a nondifferential global positioning system (GPS) to measure speed, displacement, and position during human locomotion.
  22. ncbi Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics
    Stefan R Pulver
    Brandeis University, Department of Biology, National Center of Behavioral Genomics and Volen Center for Complex Systems, Waltham, Massachusetts, USA
    Nat Neurosci 13:53-9. 2010
    ..This current also interacted with endogenous Shal K(+) conductances to modulate spike timing for multiple seconds following rhythmic activity, providing a cellular memory of network activity on a behaviorally relevant timescale...
  23. ncbi Genetic dissection of rhythmic motor networks in mice
    Katja S Grossmann
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    Prog Brain Res 187:19-37. 2010
    Simple motor behaviors such as locomotion and respiration involve rhythmic and coordinated muscle movements that are generated by central pattern generator (CPG) networks in the spinal cord and hindbrain...
  24. ncbi Bipedal locomotion in crawling cells
    Erin L Barnhart
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Biophys J 98:933-42. 2010
    ..These results demonstrate that simple elastic coupling between movement at the front of the cell and movement at the rear can generate large-scale mechanical integration of cell behavior...
  25. ncbi Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors
    Ryan M Drenan
    California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 30:9877-89. 2010
    ..These results implicate alpha6alpha4beta2* nAChRs in cholinergic control of DA transmission, and strongly suggest that these receptors are candidate drug targets for disorders involving the DA system...
  26. ncbi The evolutionary continuum of limb function from early theropods to birds
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL9 7TA, UK
    Naturwissenschaften 96:423-48. 2009
    ....
  27. ncbi Neurons regulating the duration of forward locomotion in Caenorhabditis elegans
    Tokumitsu Wakabayashi
    Laboratory of Bioscience, Faculty of Engineering, Iwate University, 4-3-5 Ueda, Morioka 020-8551, Japan
    Neurosci Res 50:103-11. 2004
    ..To gain insight into the neuronal mechanisms regulating this locomotion, we analyzed the locomotory behavior of C. elegans over a long time period...
  28. ncbi Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion
    Shawnna M Buttery
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Mol Biol Cell 14:5082-8. 2003
    ..cytosolic proteins that orchestrate the site-specific assembly and bundling of MSP filaments that generates locomotion. Here, we identify a fraction of cytosol that is comprised of a small number of proteins but contains all of the ..
  29. ncbi Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion
    David L McLean
    School of Biology, Division of Biomedical Sciences, University of St. Andrews, St. Andrews, Fife KY16 9TS, United Kingdom
    J Neurosci 22:4175-84. 2002
    ..The presynaptic and postsynaptic effects of NO act in concert to tune inhibitory synapses...
  30. ncbi Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    Hans S Keirstead
    Department of Anatomy and Neurobiology, Reeve Irvine Research Center, College of Medicine, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurosci 25:4694-705. 2005
    ..These studies document the feasibility of predifferentiating hESCs into functional OPCs and demonstrate their therapeutic potential at early time points after spinal cord injury...
  31. ncbi A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor
    S C Fowler
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, USA
    J Neurosci Methods 107:107-24. 2001
    ..Finally, potential applications in neuroscience research other than those illustrated in this report were discussed...
  32. ncbi Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: blockade by coincident inhibition of protein kinase A
    M A Sutton
    Department of Psychology, Queen s University, Kingston, Ontario, Canada
    Behav Pharmacol 11:365-76. 2000
    ..drug-free 60 min session, animals that received amphetamine/environment pairings demonstrated conditioned locomotion relative to controls...
  33. ncbi Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
    Helena A D Johard
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Comp Neurol 516:59-73. 2009
    ..Our findings emphasize that the LN(d)s are heterogeneous both anatomically and with respect to content of neuropeptides, cryptochrome, and other markers and suggest diverse functions of these neurons...
  34. ncbi Forelimb indicators of prey-size preference in the Felidae
    Julie Meachen-Samuels
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA
    J Morphol 270:729-44. 2009
    ..we found that felids and canids differ in forelimb scaling, which emphasizes the dual use of forelimbs for locomotion and prey capture in felids...
  35. ncbi A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila
    Eric C Kong
    Ernest Gallo Clinic and Research Center, Emeryville, California, United States of America
    PLoS ONE 5:e9954. 2010
    ..neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated...
  36. ncbi Leech locomotion: swimming, crawling, and decisions
    W Otto Friesen
    Department of Biology, University of Virginia, Charlottesville, VA 22903 4328, USA
    Curr Opin Neurobiol 17:704-11. 2007
    Research on the neuronal control of locomotion in leeches spans almost four decades...
  37. ncbi Red nucleus lesions impair overground locomotion in rats: a kinetic analysis
    G D Muir
    Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Eur J Neurosci 12:1113-22. 2000
    ..these structures might also be involved in control of more general limb actions, such as those occurring during locomotion. The present study investigates this question by measuring the three-dimensional ground reaction forces produced ..
  38. ncbi Spinal cord stimulation restores locomotion in animal models of Parkinson's disease
    Romulo Fuentes
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 323:1578-82. 2009
    ..We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats...
  39. ncbi The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans
    Marcus Guest
    School of Biological Sciences, Bassett Crescent East, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:1577-88. 2007
    ..has pleiotropic effects on the behaviour of the model genetic animal Caenorhabditis elegans: it inhibits locomotion, feeding, egg-laying and slows development...
  40. ncbi Large-scale association study for structural soundness and leg locomotion traits in the pig
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 41:14. 2009
    ..Few candidate genes related to soundness traits have been identified in the pig...
  41. ncbi Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion
    Martin Hägglund
    Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nat Neurosci 13:246-52. 2010
    Central pattern generators (CPGs) are spinal neuronal networks required for locomotion. Glutamatergic neurons have been implicated as being important for intrinsic rhythm generation in the CPG and for the command signal for initiating ..
  42. ncbi Marching to the beat of the same drummer: the spontaneous tempo of human locomotion
    Hamish G Macdougall
    MA Inst Technol, Cambridge
    J Appl Physiol 99:1164-73. 2005
    ..path or on a treadmill, and whether such a highly tuned frequency of movement can be generalized to all forms of locomotion in a natural setting is unknown...
  43. ncbi The locomotor kinematics of Asian and African elephants: changes with speed and size
    John R Hutchinson
    Structure and Motion Laboratory, Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL9 7TA, UK
    J Exp Biol 209:3812-27. 2006
    For centuries, elephant locomotion has been a contentious and confusing challenge for locomotion scientists to understand, not only because of technical difficulties but also because elephant locomotion is in some ways atypical of more ..
  44. ncbi UNC-1 regulates gap junctions important to locomotion in C. elegans
    Bojun Chen
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030
    Curr Biol 17:1334-9. 2007
    ..elegans, loss-of-function (lf) mutations of the stomatin-like protein (SLP) UNC-1 and the innexin UNC-9 inhibit locomotion [1, 2] and modulate sensitivity to volatile anesthetics [3, 4]...
  45. ncbi Molecular and genetic analysis of unc-7, a Caenorhabditis elegans gene required for coordinated locomotion
    T A Starich
    Department of Genetics and Cell Biology, University of Minnesota, St Paul 55108
    Genetics 133:527-41. 1993
    ..We speculate that unc-7 may be involved in the function of neuronal ion channels...
  46. ncbi NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness
    Tahir Hakami
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    PLoS ONE 4:e6755. 2009
    ..This study investigated whether NMDAr antagonists-induced aberrant gamma oscillations are correlated with locomotion and dependent on hyperlocomotion-related sensorimotor processing...
  47. ncbi Functional specialisation of pelvic limb anatomy in horses (Equus caballus)
    R C Payne
    Structure and Motion Laboratory, The Royal Veterinary College, London, UK
    J Anat 206:557-74. 2005
    ....
  48. ncbi Wing-assisted incline running and the evolution of flight
    Kenneth P Dial
    Flight Laboratory, Avian Studies Program, Division of Biological Sciences, University of Montana UM, Missoula, MT 59812, USA
    Science 299:402-4. 2003
    ..WAIR provides insight from behaviors observable in living birds into the possible role of incipient wings in feathered theropod dinosaurs and offers a previously unstudied explanation for the evolution of avian flight...
  49. ncbi A fundamental avian wing-stroke provides a new perspective on the evolution of flight
    Kenneth P Dial
    Flight Laboratory, Division of Biological Sciences, University of Montana, 32 Campus Drive, Missoula, Montana 59812, USA
    Nature 451:985-9. 2008
    ....
  50. ncbi The primate semicircular canal system and locomotion
    Fred Spoor
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:10808-12. 2007
    ..semicircular canal system of vertebrates helps coordinate body movements, including stabilization of gaze during locomotion. Quantitative phylogenetically informed analysis of the radius of curvature of the three semicircular canals in ..
  51. ncbi Electrotaxis of Caenorhabditis elegans in a microfluidic environment
    Pouya Rezai
    Department of Mechanical Engineering, McMaster University, JHE 212 B, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Lab Chip 10:220-6. 2010
    ..This opens up significant possibilities for high-throughput screening of C. elegans for drug discovery and other applications...
  52. ncbi Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutants
    Jason C Caldwell
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 100:16053-8. 2003
    ..These oscillatory networks elicit locomotion in the absence of external sensory or descending inputs, but CPG circuits produce more directed and behaviorally ..
  53. ncbi Maternal iron deficiency alters essential fatty acid and eicosanoid metabolism and increases locomotion in adult guinea pig offspring
    Caroline P LeBlanc
    Ecole des sciences des aliments, de Nutrition et d Etudes Familiales, Universite de Moncton, Moncton, NB E1A 3E9 Canada
    J Nutr 139:1653-9. 2009
    ..b>Locomotion was tested in pups on postnatal d 24 and 40 and spatial memory from d 25 to 40...
  54. ncbi Time-dependent actions of D2 family agonist quinpirole on spontaneous behavior in the rat: dissociation between sniffing and locomotion
    J C Horvitz
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, Room 406, New York, NY 10027, USA
    Psychopharmacology (Berl) 154:350-5. 2001
    Dopamine agonists elevate locomotion, sniffing, grooming, and a number of other behaviors...
  55. ncbi Spatiotemporal dynamics of rhythmic spinal interneurons measured with two-photon calcium imaging and coherence analysis
    Alex C Kwan
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA
    J Neurophysiol 104:3323-33. 2010
    ..showed rhythmic activity that was coherent and in phase with the ipsilateral motor output during fictive locomotion. The phase distributions of two genetically identified classes of interneurons were distinct from the ensemble ..
  56. ncbi Effects of neck and circumoesophageal connective lesions on posture and locomotion in the cockroach
    Angela L Ridgel
    Department of Biology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7080, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191:559-73. 2005
    Few studies in arthropods have documented to what extent local control centers in the thorax can support locomotion in absence of inputs from head ganglia...
  57. ncbi Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of Caenorhabditis elegans
    Kathryn Bull
    Neuroscience Research Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:627-36. 2007
    ..2003), pharynx (Willson et al., 2004) and egg-laying muscles and thus inhibits three important physiological functions: locomotion, feeding and reproduction.
  58. ncbi Visual exteroceptive information provided during obstacle crossing did not modify the lower limb trajectory
    Chris K Rhea
    Department of Health and Kinesiology, 800 West Stadium Ave, Purdue University, West Lafayette, IN 47906, United States
    Neurosci Lett 418:60-5. 2007
    ..These observations strengthen the argument that it is the visual exproprioceptive information, not visual exteroceptive information, that is used on-line to fine tune the lower limb trajectory during obstacle avoidance...
  59. ncbi Experiments and models of sensorimotor interactions during locomotion
    Alain Frigon
    Center and Group for Neurological Sciences, Department of Physiology, CIHR Group in Neurological Sciences, CIHR Regenerative Medicine and Nanomedicine Team, , Quebec, Canada
    Biol Cybern 95:607-27. 2006
    During locomotion sensory information from cutaneous and muscle receptors is continuously integrated with the locomotor central pattern generator (CPG) to generate an appropriate motor output to meet the demands of the environment...
  60. ncbi Stenotrophomonas maltophilia strains from cystic fibrosis patients: genomic variability and molecular characterization of some virulence determinants
    Mauro Nicoletti
    Dipartimento Scienze Biomediche, Universita G D Annunzio, Via dei Vestini, 31 Chieti, Italy
    Int J Med Microbiol 301:34-43. 2011
    ..The results obtained strongly indicate that the major extracellular protease StmPr1 may be a relevant virulence factor of S. maltophilia...
  61. ncbi Evolution of chameleon locomotion, or how to become arboreal as a reptile
    Martin S Fischer
    Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich Schiller Universitat Jena, Erbertstr 1, D 07743 Jena, Germany
    Zoology (Jena) 113:67-74. 2010
    ..have led to the identification of those traits which are considered to be crucial for the evolution of arboreal locomotion in chameleons...
  62. ncbi Obstacle crossing with lower visual field restriction: shifts in strategy
    Sander E M Jansen
    TNO Human Factors, Soesterberg, The Netherlands
    J Mot Behav 43:55-62. 2011
    ..These results are discussed in terms of a change in priorities, from conservation of energy and time to safety...
  63. ncbi Human hippocampal activation during stance and locomotion: fMRI study on healthy, blind, and vestibular-loss subjects
    Klaus Jahn
    Ludwig Maximilians University, Klinikum Grosshadern, Department of Neurology, Marchioninistrasse, Munich, Germany
    Ann N Y Acad Sci 1164:229-35. 2009
    ..the hippocampal formation could be defined from the analysis of brain activity during imagery of stance and locomotion in healthy, blind, and vestibular-loss subjects...
  64. ncbi Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord
    Guisheng Zhong
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 27:4507-18. 2007
    ..The role of I(Na(P)) in locomotor pattern generation was examined by applying riluzole during fictive locomotion induced by NMDA, serotonin, and dopamine or by stimulation of the cauda equina...
  65. ncbi Gait parameters of treadmill versus overground locomotion in mouse
    Marc Herbin
    U S M 0302, CNRS, MNHN, Univ Paris 6, College de France, Paris Cedex 05, France
    Behav Brain Res 181:173-9. 2007
    ..the literature in mammals shows a wide difference of results between the kinematics of treadmill and overground locomotion. To study these discrepancies, we analyzed the locomotion of adult SWISS-OF1 mice over a large range of ..
  66. ncbi Hindlimb function in the alligator: integrating movements, motor patterns, ground reaction forces and bone strain of terrestrial locomotion
    Stephen M Reilly
    Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
    J Exp Biol 208:993-1009. 2005
    Alligator hindlimbs show high torsional loads during terrestrial locomotion, in sharp contrast to the bending or axial compressive loads that predominate in animals that use parasagittal limb movements...
  67. ncbi Keep looking ahead? Re-direction of visual fixation does not always occur during an unpredictable obstacle avoidance task
    Daniel S Marigold
    Gait and Posture Lab, Department of Kinesiology, University of Waterloo, 200 University Ave West, Waterloo, ON, Canada
    Exp Brain Res 176:32-42. 2007
    ..information about the environment, especially fixation of key objects such as obstacles, is critical for safe locomotion. However, in unpredictable situations where an obstacle suddenly appears it is not known whether central vision ..
  68. ncbi Epidural stimulation: comparison of the spinal circuits that generate and control locomotion in rats, cats and humans
    Yury Gerasimenko
    Department of Physiological Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Exp Neurol 209:417-25. 2008
    ..considerable progress has been made in realizing the potential of epidural stimulation to facilitate posture and locomotion in subjects with severe spinal cord injury who lack the ability to stand or to step...
  69. ncbi Arboreal bipedalism in wild chimpanzees: implications for the evolution of hominid posture and locomotion
    Craig B Stanford
    Department of Anthropology, University of Southern California, Los Angeles, 90089 0032, USA
    Am J Phys Anthropol 129:225-31. 2006
    Field observations of bipedal posture and locomotion in wild chimpanzees (Pan troglodytes) can serve as key evidence for reconstructing the likely origins of bipedalism in the last prehominid human ancestor...
  70. ncbi Visual-vestibular interaction during goal directed locomotion: effects of aging and blurring vision
    Nandini Deshpande
    Gait and Posture Lab, Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada
    Exp Brain Res 176:43-53. 2007
    Normal vision overrides perturbed vestibular information for the optimization of performance during goal directed locomotion, suggesting down-regulation of vestibular gain...
  71. ncbi Stride lengths, speed and energy costs in walking of Australopithecus afarensis: using evolutionary robotics to predict locomotion of early human ancestors
    William I Sellers
    Loughborough University, Department of Human Sciences, Loughborough LE11 3TU, UK
    J R Soc Interface 2:431-41. 2005
    ..7 and 1.0 m s-1, respectively. The predictions conflict with suggestions that A. afarensis used a 'shuffling' gait, indicating rather that the species was a fully competent biped...
  72. ncbi Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction
    K Takakusaki
    Department of Physiology, College of Medicine, Asahikawa Medical College, Midorigaoka Higashi 2 1, Asahikawa 078 8510, Japan
    Neuroscience 119:293-308. 2003
    ..acid and kainic acid) or GABA antagonists (bicuculline and picrotoxin) into the MLR and PPN also induced locomotion and muscle-tone suppression, respectively...
  73. ncbi Kismet/CHD7 regulates axon morphology, memory and locomotion in a Drosophila model of CHARGE syndrome
    David J Melicharek
    Department of Biology, Drexel University, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:4253-64. 2010
    ..We suggest that the analysis of this disease model can complement and expand upon the existing studies for this disease, allowing a better understanding of the role of kismet in neural developmental, and Chd7 in CS pathogenesis...
  74. ncbi Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment
    Marianne H Larsen
    Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen N, Denmark
    J Psychiatr Res 44:808-16. 2010
    ..However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity...
  75. ncbi Age-related modifications in steering behaviour: effects of base-of-support constraints at the turn point
    Maxime R Paquette
    Department of Human Biology and Nutritional Sciences, Animal Science Nutrition Bldg, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Exp Brain Res 190:1-9. 2008
    ..The results of this study provide insight into mobility constraints during a common locomotor task in older adults...
  76. ncbi "Look where you're going!": gaze behaviour associated with maintaining and changing the direction of locomotion
    M A Hollands
    Academic Department of Neurootology, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London, UK
    Exp Brain Res 143:221-30. 2002
    In order to fully understand how vision is used to guide locomotion it is necessary to know what people look at as they move through the environment...
  77. ncbi Robotic gait analysis of bipedal treadmill stepping by spinal contused rats: characterization of intrinsic recovery and comparison with BBB
    Jeff A Nessler
    Department of Mechanical and Aerospace Engineering, University of California, Irvine, California 92697-3975, USA
    J Neurotrauma 23:882-96. 2006
    ..stepping change following contusion, and whether these changes correlate with the recovery of open field locomotion. Female, Sprague-Dawley rats (n=29, 8 weeks of age) received mid thoracic contusion injuries of differing ..
  78. ncbi Phase-specific sensory representations in spinocerebellar activity during stepping: evidence for a hybrid kinematic/kinetic framework
    G Bosco
    Department of Neuroscience, University of Rome Tor Vergata, IRCCS Fondazione Santa Lucia, Rome, Italy
    Exp Brain Res 175:83-96. 2006
    ..a major mossy fiber input to the spinocerebellum, which plays a significant role in the control of posture and locomotion. Recent work from our laboratory has provided evidence that DSCT neurons encode a global representation of ..
  79. ncbi Dynamics of quadrupedal locomotion of monkeys: implications for central control
    Yongqing Xiang
    Department of Computer and Information Science, Brooklyn College, CUNY, Brooklyn, NY 11210, USA
    Exp Brain Res 177:551-72. 2007
    ....
  80. ncbi Locomotor versatility in the white-handed gibbon (Hylobates lar): a spatiotemporal analysis of the bipedal, tripedal, and quadrupedal gaits
    Evie E Vereecke
    Laboratory for Functional Morphology, University of Antwerp, Universiteitsplein 1 B 2610 Wilrijk, Antwerp, Belgium
    J Hum Evol 50:552-67. 2006
    ..The gibbons were filmed during voluntary locomotion on a grassy and smooth substrate and on a pole...
  81. ncbi Neuromechanical control of locomotion in the rat
    Anil K Thota
    Center for Rehabilitation Neuroscience and Rehabilitation Engineering, The Biodesign Institute and The Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287, USA
    J Neurotrauma 22:442-65. 2005
    ..Data and techniques described here are likely to be useful for quantitative assessment of altered gait and neural control mechanisms after neurotrauma...
  82. ncbi The control system for the Honda humanoid robot
    Toru Takenaka
    Wako Research Centre, Honda R and D Co, Ltd, 8 1 Honcho, Wako Shi, Saitama Prefecture 351 0114, Japan
    Age Ageing 35:ii24-ii26. 2006
    ..In this article, we present the history of robot development at Honda, fundamental dynamics for robots and the principles of posture control...
  83. ncbi Contribution of cutaneous inputs from the hindpaw to the control of locomotion in rats
    Artur S P Varejao
    Department of Veterinary Sciences, CETAV, University of Tras os Montes e Alto Douro, P O Box 1013, 5001 801 Vila Real, Portugal
    Behav Brain Res 176:193-201. 2007
    The influence of reduced feedback from the cutaneous receptors in the hindpaw in rat locomotion is still unclear...
  84. ncbi Hindlimb claudication reflects impaired nitric oxide-dependent revascularization after ischemia
    Diana Luque Contreras
    Department of Molecular Biomedicine, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Avenida Instituto Politecnico Nacional 2508, Colonia San Pedro Zacatenco, Mexico City, Mexico
    Vascul Pharmacol 46:10-5. 2007
    ..revascularization and tested the effects of NO synthase inhibition on both hindlimb blood flow and hindlimb gait locomotion. After 14 days of ischemia, the ischemic hindlimb showed no significant differences in gait locomotion compared ..
  85. ncbi Mechanical power and efficiency of level walking with different stride rates
    Brian R Umberger
    Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, USA
    J Exp Biol 210:3255-65. 2007
    ..This may also explain the relative flatness of the curve for metabolic rate in the vicinity of the preferred stride rate...
  86. ncbi Epidural spinal cord stimulation plus quipazine administration enable stepping in complete spinal adult rats
    Yury P Gerasimenko
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 98:2525-36. 2007
    ..and extensor related intraspinal neural networks in qualitatively unique, but complementary, ways to facilitate locomotion in spinal cord-injured rats...
  87. ncbi Organisation of the spinal central pattern generators for locomotion in the salamander: biology and modelling
    Stéphanie Chevallier
    INSERM U 862, Universite Bordeaux 2, Institut Francois Magendie, 146 rue Leo Saignat, 33077 Bordeaux Cedex, France
    Brain Res Rev 57:147-61. 2008
    ..Altogether, the neurobiological and the modelling data support the hypothesis of a phylogenetic conservatism from agnathians to amphibians of the spinal locomotor networks generating axial motor patterns...
  88. ncbi A hexapedal jointed-leg model for insect locomotion in the horizontal plane
    Raghavendra P Kukillaya
    Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA
    Biol Cybern 97:379-95. 2007
    We develop a simple model for insect locomotion in the horizontal (ground) plane. As in earlier work by Seipel et al...
  89. ncbi Temporospatial and kinetic characteristics of sheep walking on a pressure sensing walkway
    JongMin Kim
    Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907, USA
    Can J Vet Res 72:50-5. 2008
    ..The PS walkway enabled collection of temporospatial and kinetic data, and simplified the process of data collection...
  90. ncbi Characteristics of instructed and uninstructed interpersonal coordination while walking side-by-side
    Niek R van Ulzen
    Department of Social Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Neurosci Lett 432:88-93. 2008
    ..When the typically involved parameter constraints are relaxed, however, this model may largely account for the observed dynamical characteristics...
  91. ncbi New technique for drug application to the spinal cord of walking mice
    Turgay Akay
    Department of Physiology, University of Alberta, 755 Medical Science Building, Edmonton, Alberta T6G 2H7, Canada
    J Neurosci Methods 171:39-47. 2008
    ..Combining this method with kinematic and electromyographic recording techniques allows the detailed investigation of the effects of drugs on the walking behavior in adult mice...
  92. ncbi Assessing the rider's seat and horse's behavior: difficulties and perspectives
    Mari Zetterqvist Blokhuis
    Ridskolan Stromsholm, Stockholm, Sweden
    J Appl Anim Welf Sci 11:191-203. 2008
    ..Seven of 9 riders in the experimental group had the impression that the exercises improved their riding performance. There is a clear need to develop a robust system that allows trainers to objectively evaluate the rider's seat...
  93. ncbi Walking speed, cadence and step length are selected to optimize the stability of head and pelvis accelerations
    Mark D Latt
    Department of Geriatric Medicine, Westmead Hospital, Westmead, NSW, Australia
    Exp Brain Res 184:201-9. 2008
    ..The findings suggest that healthy young people walk in a manner that maximizes V and AP stability while maintaining adequate, though suboptimal ML stability...
  94. ncbi Kinetic gait analysis of healthy dogs on two different surfaces
    Amy S Kapatkin
    Department of Clinical Studies PHL, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Vet Surg 36:605-8. 2007
    ..To determine the effects of 2 different, commonly used surfaces with different coefficients of friction on ground reaction forces in normal dogs...
  95. ncbi Long-lasting, context-dependent modification of stepping in the cat after repeated stumbling-corrective responses
    D A McVea
    Department of Physiology, 7 55 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Neurophysiol 97:659-69. 2007
    A consistent feature of animal locomotion is the capacity to maintain stable movements in changing environments...
  96. ncbi Descending control of turning behavior in the cockroach, Blaberus discoidalis
    Angela L Ridgel
    Department of Biology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 7080, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:385-402. 2007
    Legged locomotion has evolved as the most effective form of movement through unpredictable and tortuous environments...
  97. ncbi Morphological changes in pedal phalanges through ornithopod dinosaur evolution: a biomechanical approach
    Karen Moreno
    Department of Earth Sciences, University of Bristol, Bristol BS8 1RJ, UK
    J Morphol 268:50-63. 2007
    ..These conclusions can be applied to other, parallel evolutionary changes (in both dinosaurs and mammals) that involved similar transitions to a subunguligrade posture...
  98. ncbi Intraspinal stimulation caudal to spinal cord transections in rats. Testing the propriospinal hypothesis
    Sergiy Yakovenko
    Departement de Physiologie, Universite de Montreal, Pavillon Paul G Desmarais, C P 6128, Succursale Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    J Neurophysiol 97:2570-4. 2007
    ..increased BBB scores over control tests, but did not produce limb coordination and weight bearing sufficient for locomotion. These results support the main assumption of the propriospinal hypothesis: that neuronal activity elicited in ..
  99. ncbi Differential activity-dependent development of corticospinal control of movement and final limb position during visually guided locomotion
    K M Friel
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    J Neurophysiol 97:3396-406. 2007
    ..during the corticospinal axon terminal refinement period, between postnatal weeks 5-7, on visually guided locomotion. We examined stepping and forepaw placement on the rungs of a horizontal ladder and gait modifications as ..
  100. ncbi Bilateral dorsal funicular lesions alter sensorimotor behaviour in rats
    Srikanth G Kanagal
    Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan Saskatoon, Canada SK S7N 5B4
    Exp Neurol 205:513-24. 2007
    ..forces exerted on the ground (ground reaction forces, GRF) and limb contact patterns produced during overground locomotion. After ASP lesions alone, endpoint measurements of reaching success and footslip errors on the ladder showed ..
  101. ncbi Trunk sensorimotor cortex is essential for autonomous weight-supported locomotion in adult rats spinalized as P1/P2 neonates
    Simon Giszter
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 100:839-51. 2008
    ..We tested the importance of trunk sensorimotor cortex in their locomotion using lesions guided by cortical microstimulation in P1/P2 weight-supporting neonatal spinalized rats and ..

Research Grants89

  1. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2010
    ..Although tizanidine has been used to treat spasticity, and the LOKOMAT to improve locomotion, there have been no prior attempts to characterize the interactions between these therapies...
  2. Mechanisms of Therapeutic Action in SCI
    MEHDI MIRBAGHERI; Fiscal Year: 2009
    ..Although tizanidine has been used to treat spasticity, and the LOKOMAT to improve locomotion, there have been no prior attempts to characterize the interactions between these therapies...
  3. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..for H-reflex change; that cerebellar output to SMC is essential; and that H-reflex conditioning affects locomotion and can improve it after spinal cord injury...
  4. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..for H-reflex change; that cerebellar output to SMC is essential; and that H-reflex conditioning affects locomotion and can improve it after spinal cord injury...
  5. Changing a reflex to improve locomotion
    Aiko Thompson; Fiscal Year: 2010
    ..The goal of this project is to investigate the impact of changing a spinal reflex on impaired locomotion after chronic incomplete SCI in people...
  6. Spinal Reflex Conditioning and Locomotion
    JONATHAN RICKEL contact WOLPAW; Fiscal Year: 2010
    ..Recent work shows that soleus H-reflex conditioning changes soleus behavior during locomotion, and suggests that appropriate conditioning can improve locomotion after a spinal cord injury...
  7. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
    ..Recent work shows that soleus H-reflex conditioning changes soleus behavior during locomotion, and suggests that appropriate conditioning can improve locomotion after a spinal cord injury...
  8. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..is for SBIR Phase I research to determine the design and feasibility of an innovative, new device for advanced locomotion analysis including: ambulation assessment and fall prevention, postural perturbation assessment and activity ..
  9. Robotic Prosthesis for Biomimetic Locomotion in Transfemoral Amputees
    Michael Goldfarb; Fiscal Year: 2007
    ..disparity between transfemoral amputees and healthy persons during level walking, and by enabling forms of locomotion, such as ramp and stair climbing, not presently afforded by state-of-the-art devices...
  10. Task space control of normal & pathological locomotion
    CHENG YUN KAREN LIU; Fiscal Year: 2010
    ..Extensive research has detailed joint kinematics and kinetics of human locomotion and movement control with normal and various motor function disorders...
  11. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    ..progression with locomotor recovery, as defined by a battery of neurologic tests that evaluate coordinated locomotion, hind limb paw position during locomotion, and performance on an inclined grid...
  12. Signals Regulating Vestibular Endolymph Homeostasis
    Mark Henkemeyer; Fiscal Year: 2005
    ..Preliminary studies show that adult mice mutant for the EphB2 receptor tyrosine kinase display a circling locomotion consistent with a defect in vestibular function...
  13. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory I Goldberg; Fiscal Year: 2010
    ..These findings have profound implications for a mechanistic understanding of the role of MMPs in cell locomotion in a collagen rich microenvironment. We thus propose a model for a Mobile Cell Surface Collagenolytic Interface...
  14. COLLAGENOLYSIS-DRIVEN MOLECULAR MOTORS IN CELL MIGRATION AND MATRIX REMODELING
    Gregory Goldberg; Fiscal Year: 2009
    ..These findings have profound implications for a mechanistic understanding of the role of MMPs in cell locomotion in a collagen rich microenvironment. We thus propose a model for a Mobile Cell Surface Collagenolytic Interface...
  15. Elastic mechanisms in locomotion
    THOMAS JAY ROBERTS; Fiscal Year: 2010
    ..contractile elements can significantly influence the force, power and displacement of muscle fibers during locomotion. All movements involve dynamic interaction between passive elastic structures and muscle contractile elements, ..
  16. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew A Biewener; Fiscal Year: 2010
    ..that: (a) differential patterns of motor recruitment (between the fast and slow units) occur during goat locomotion, and (b) the faster motor units are preferentially activated, relative to slow units, for tasks that require ..
  17. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew Biewener; Fiscal Year: 2009
    ..that: (a) differential patterns of motor recruitment (between the fast and slow units) occur during goat locomotion, and (b) the faster motor units are preferentially activated, relative to slow units, for tasks that require ..
  18. CRCNS: Role of sensory feedback in locomotor recovery after spinal cord injury
    Michel A Lemay; Fiscal Year: 2010
    Afferent feedback plays a critical role in the control of locomotion and in the recovery afforded by body-weight supported treadmill training or graft of neurotrophin producing cellular transplants after spinal cord injury (SCI)...
  19. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    REGGIE EDGERTON; Fiscal Year: 2010
    ..This technology has the potential to significantly improve the recovery of posture and locomotion in individuals with a severe spinal cord injury...
  20. Spinal Epidural Electrode Array to Facilitate Standing and Stepping After SCI
    V Edgerton; Fiscal Year: 2009
    ..This technology has the potential to significantly improve the recovery of posture and locomotion in individuals with a severe spinal cord injury...
  21. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2007
    ..All of these observations indicate that the interneuronal network in lumbar spinal cord can carry out locomotion after SCI, if it can be activated properly...
  22. Re-training locomotor circuitry in a rat model of Spinal Cord Injury
    DAVID MAGNUSON; Fiscal Year: 2007
    ..therapy seeks to re-train the spinal cord circuitry below the level of injury to participate in functional locomotion. The mammalian spinal cord, humans included, contains complex neuronal circuitry that participates in the ..
  23. Central Modulation of Rhythms
    EDGAR E GARCIA RILL; Fiscal Year: 2010
    The pedunculopontine nucleus (PPN) helps control sleep-wake rhythms and modulates posture and locomotion. The proposed research will address three functional aspects (ascending, local and descending) of the PPN, the cholinergic arm of ..
  24. FUNCTIONAL REGENERATION OF LOCOMOTOR COMMAND NEURONS
    ANDREW MCCLELLAN; Fiscal Year: 1993
    In normal lampreys some of the brainstem command neurons which initiate locomotion are reticulospinal (RS) neurons in the medial and posterior rhombencephalic reticular nuclei (MRRN and PRRN) that have descending axons in the latcral ..
  25. Mechanical Plasticity in Locomotion with Age
    PAUL DE VITA; Fiscal Year: 2007
    ..plasticity emphasizing proximal muscles as a compensatory mechanism for reduced distal muscle function in locomotion. Pilot data show that while walking at the same speed, healthy old vs...
  26. FUNCTION AND REGULATION OF THE HUMAN ARP2/3 COMPLEX
    Matthew D Welch; Fiscal Year: 2010
    The actin cytoskeleton plays an essential role in basic cellular processes including locomotion, membrane transport, and cytokinesis...
  27. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2010
    ..We have found that galanin knockout mice show increased morphine-induced locomotion and conditioned place preference (CPP), and that these behavioral phenotypes are correlated with increased ..
  28. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2005
    ..Some animal and clinical studies indicate that muscle activation patterns during locomotion are hardwired into the nervous system and incapable of substantial modification...
  29. Unintended muscle activity influences on post-stroke locomotion
    CITLALI LOPEZ ORTIZ; Fiscal Year: 2007
    ..Our lab has shown that there is inappropriate coordination of muscle activity in post-stroke locomotion and that the reaction force against the supporting surface is compromised, in both magnitude and direction...
  30. Motor Systems Supporting Pavlovian Conditioning
    Terry Crow; Fiscal Year: 2007
    ..project is to identify the neural circuit that is responsible for the generation of light-elicited ciliary locomotion and reflex-elicited foot contraction; and to understand how Pavlovian conditioning changes synaptic connections ..
  31. CENTRAL MODULATION OF LOCOMOTOR RHYTHMS
    Edgar Garcia Rill; Fiscal Year: 1991
    ..region (MLR) is known to initiate and maintain walking in the brainstem- transected animal by modulating locomotion oscillators present in the spinal cord...
  32. ANTERIOR CRUCIATE LIGAMENT-FUNCTIONAL BIOMECHANICS
    Thomas Andriacchi; Fiscal Year: 2004
    ..Is it possible that altered patterns of locomotion dynamically compensate for loss of the ACT? Quantifying the relationship between altered patterns of locomotion ..
  33. Psychostimulants and Alpha-1 Adrenoceptor Subtypes
    Paul Wellman; Fiscal Year: 2006
    Psychostimulant-induced changes in locomotion involve activation of the 1B subtype of the a 1 -adrenoceptor (a 1B-AR)...