movement

Summary

Summary: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.

Top Publications

  1. ncbi Neuronal ensemble control of prosthetic devices by a human with tetraplegia
    Leigh R Hochberg
    Department of Neurology, Massachusetts General Hospital, Brigham and Women s Hospital, and Spaulding Rehabilitation Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 442:164-71. 2006
  2. ncbi Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
  3. ncbi Somatotopic representation of action words in human motor and premotor cortex
    Olaf Hauk
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    Neuron 41:301-7. 2004
  4. pmc Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement
    G W Gant Luxton
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Science 329:956-9. 2010
  5. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
  6. ncbi Motor imagery
    Martin Lotze
    Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University of Tubingen, D 72074 Tubingen, Germany
    J Physiol Paris 99:386-95. 2006
  7. ncbi Computational principles of movement neuroscience
    D M Wolpert
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK
    Nat Neurosci 3:1212-7. 2000
  8. ncbi Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement
    Mario Manto
    Unité d Etude du Mouvement, FNRS, ULB Erasme, 808 Route de Lennik, Brussels, Belgium
    Cerebellum 11:457-87. 2012
  9. pmc Optimality principles in sensorimotor control
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
    Nat Neurosci 7:907-15. 2004
  10. ncbi Rocking together: dynamics of intentional and unintentional interpersonal coordination
    Michael J Richardson
    Department of Psychology, Colby College, Mayflower Hill, Waterville, ME 04901, USA
    Hum Mov Sci 26:867-91. 2007

Detail Information

Publications336 found, 100 shown here

  1. ncbi Neuronal ensemble control of prosthetic devices by a human with tetraplegia
    Leigh R Hochberg
    Department of Neurology, Massachusetts General Hospital, Brigham and Women s Hospital, and Spaulding Rehabilitation Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 442:164-71. 2006
    Neuromotor prostheses (NMPs) aim to replace or restore lost motor functions in paralysed humans by routeing movement-related signals from the brain, around damaged parts of the nervous system, to external effectors...
  2. ncbi Reliability and validity of the combined heart rate and movement sensor Actiheart
    S Brage
    MRC Epidemiology Unit, Institute of Public Health, University of Cambridge, CB1 9NL, UK
    Eur J Clin Nutr 59:561-70. 2005
    ..The Actiheart, a combined heart rate (HR) and movement sensor, is designed to assess physical activity in populations.
  3. ncbi Somatotopic representation of action words in human motor and premotor cortex
    Olaf Hauk
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
    Neuron 41:301-7. 2004
    ..areas along the motor strip that either were directly adjacent to or overlapped with areas activated by actual movement of the tongue, fingers, or feet...
  4. pmc Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement
    G W Gant Luxton
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Science 329:956-9. 2010
    ..Many nuclear movements are microtubule-dependent. However, nuclear movement to reorient the centrosome in migrating fibroblasts occurs through an unknown actin-dependent mechanism...
  5. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
    ..We present experimental results from a range of motor tasks to support this theory...
  6. ncbi Motor imagery
    Martin Lotze
    Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University of Tubingen, D 72074 Tubingen, Germany
    J Physiol Paris 99:386-95. 2006
    ..Finally we provide an outlook on additional work about motor imagery important for further understanding of the topic...
  7. ncbi Computational principles of movement neuroscience
    D M Wolpert
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK
    Nat Neurosci 3:1212-7. 2000
    Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning...
  8. ncbi Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement
    Mario Manto
    Unité d Etude du Mouvement, FNRS, ULB Erasme, 808 Route de Lennik, Brussels, Belgium
    Cerebellum 11:457-87. 2012
    ..voluntary limb movements, timing, sensorimotor synchronization, control of corticomotor excitability, control of movement-related sensory data acquisition, cerebro-cerebellar interaction in visuokinesthetic perception of hand movement, ..
  9. pmc Optimality principles in sensorimotor control
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
    Nat Neurosci 7:907-15. 2004
    ..Traditional emphasis has been on optimizing desired movement trajectories while ignoring sensory feedback...
  10. ncbi Rocking together: dynamics of intentional and unintentional interpersonal coordination
    Michael J Richardson
    Department of Psychology, Colby College, Mayflower Hill, Waterville, ME 04901, USA
    Hum Mov Sci 26:867-91. 2007
    ..The results of the visual focus manipulations indicate that the stability of a visual interpersonal coupling is mediated by attention and the degree to which an individual is able to detect information about a co-actor's movements...
  11. ncbi Control of fast-reaching movements by muscle synergy combinations
    Andrea d'Avella
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 26:7791-810. 2006
    ..synergies whose combinations, after scaling in amplitude and shifting in time each synergy independently for each movement condition, explained 73-82% of the data variation...
  12. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
    ..The central nervous system therefore employs probabilistic models during sensorimotor learning...
  13. ncbi ISB recommendation on definitions of joint coordinate systems of various joints for the reporting of human joint motion--Part II: shoulder, elbow, wrist and hand
    Ge Wu
    Department of Physical Therapy, University of Vermont, 305 Rathwell Building, Burlington, VT, USA
    J Biomech 38:981-992. 2005
    ..Adopting these standards will lead to better communication among researchers and clinicians...
  14. ncbi Decoding natural grasp types from human ECoG
    Tobias Pistohl
    Bernstein Center Freiburg BCF, 79104 Freiburg, Germany
    Neuroimage 59:248-60. 2012
    Electrocorticographic (ECoG) signals have been successfully used to provide information about arm movement direction, individual finger movements and even continuous arm movement trajectories...
  15. ncbi Type IV pili and twitching motility
    John S Mattick
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Annu Rev Microbiol 56:289-314. 2002
    ..Twitching motility is also controlled by a range of signal transduction systems, including two-component sensor-regulators and a complex chemosensory system...
  16. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    Repeated periods of stimulation of the spinal cord and training increased the ability to control movement in animal models of spinal cord injury...
  17. ncbi Conscious intention and motor cognition
    Patrick Haggard
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Trends Cogn Sci 9:290-5. 2005
    ..Both intention and agency result from the brain processes for predictive motor control, not merely from retrospective inference...
  18. pmc A field guide to bacterial swarming motility
    Daniel B Kearns
    Indiana University, Bloomington, Indiana 47405, USA
    Nat Rev Microbiol 8:634-44. 2010
    ..Much less is known about how some bacteria use flagella to move over the tops of solid surfaces in a form of movement called swarming...
  19. ncbi Error correction, sensory prediction, and adaptation in motor control
    Reza Shadmehr
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Neurosci 33:89-108. 2010
    ..The second problem is that the relationship between a motor command and the movement it produces is variable, as the body and the environment can both change...
  20. ncbi The neural basis of decision making
    Joshua I Gold
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6074, USA
    Annu Rev Neurosci 30:535-74. 2007
    ..We focus on simple decisions that can be studied in the laboratory but emphasize general principles likely to extend to other settings...
  21. ncbi What is the Bereitschaftspotential?
    Hiroshi Shibasaki
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Clin Neurophysiol 117:2341-56. 2006
    Since discovery of the slow negative electroencephalographic (EEG) activity preceding self-initiated movement by Kornhuber and Deecke [Kornhuber HH, Deecke L...
  22. ncbi Intracellular parasite invasion strategies
    L D Sibley
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 304:248-53. 2004
    ..Efficient invasion has brought widespread success to this group, which includes Toxoplasma, Plasmodium, and Cryptosporidium...
  23. ncbi Accelerometry: a technique for quantifying movement patterns during walking
    Justin J Kavanagh
    School of Physiotherapy and Exercise Science, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Gait Posture 28:1-15. 2008
    The popularity of using accelerometer-based systems to quantify human movement patterns has increased in recent years for clinicians and researchers alike...
  24. pmc Control of a two-dimensional movement signal by a noninvasive brain-computer interface in humans
    Jonathan R Wolpaw
    Laboratory of Nervous System Disorders, Wadsworth Center, New York State Department of Health and State University of New York, Albany, NY 12201 0509, USA
    Proc Natl Acad Sci U S A 101:17849-54. 2004
    ..widely assumed that only invasive BCIs, which use electrodes implanted in the brain, can provide multidimensional movement control of a robotic arm or a neuroprosthesis...
  25. ncbi Intentional maps in posterior parietal cortex
    Richard A Andersen
    Division of Biology, California Institute of Technology, Mail code 216 76, Pasadena 91125, USA
    Annu Rev Neurosci 25:189-220. 2002
    ..Among its functions is the forming of intentions, that is, high-level cognitive plans for movement. There is a map of intentions within the PPC, with different subregions dedicated to the planning of eye ..
  26. ncbi The role of motor contagion in the prediction of action
    Sarah Jayne Blakemore
    Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, UK
    Neuropsychologia 43:260-7. 2005
    ..There is neurophysiological evidence that neurons in premotor cortex of monkeys respond both during movement execution and during the observation of goal-directed action ('mirror neurons')...
  27. ncbi Descending pathways in motor control
    Roger N Lemon
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    Annu Rev Neurosci 31:195-218. 2008
    ....
  28. ncbi OpenSim: open-source software to create and analyze dynamic simulations of movement
    Scott L Delp
    Department of Bioengineering, Stanford University, Clark Center, Room S 170, 318 Campus Drive, Stanford, CA 94305 5450, USA
    IEEE Trans Biomed Eng 54:1940-50. 2007
    Dynamic simulations of movement allow one to study neuromuscular coordination, analyze athletic performance, and estimate internal loading of the musculoskeletal system...
  29. ncbi Prediction of arm movement trajectories from ECoG-recordings in humans
    Tobias Pistohl
    Bernstein Center for Computational Neuroscience, Albert Ludwigs University, Freiburg, Germany
    J Neurosci Methods 167:105-14. 2008
    ..However, previous approaches to ECoG-BMIs were either based on classification of different movement patterns or on a voluntary modulation of spectral features...
  30. ncbi Action plans used in action observation
    J Randall Flanagan
    Department of Psychology and Centre for Neuroscience Studies, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nature 424:769-71. 2003
    ..These results indicate that during action observation subjects implement eye motor programs directed by motor representations of manual actions and thus provide strong evidence for the direct matching hypothesis...
  31. ncbi Combining modules for movement
    E Bizzi
    Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technolgy 46 6189, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Brain Res Rev 57:125-33. 2008
    ..Such an organization might help to simplify the production of movements by reducing the degrees of freedom that need to be specified...
  32. ncbi Decoding two-dimensional movement trajectories using electrocorticographic signals in humans
    G Schalk
    BCI R and D Progr, Wadsworth Ctr, NYS Department of Health, Albany, NY, USA
    J Neural Eng 4:264-75. 2007
    ..BCI research strategy begins by decoding kinematic parameters from brain signals recorded during actual arm movement. It has been assumed that these parameters can be derived accurately only from signals recorded by intracortical ..
  33. pmc How vision and movement combine in the hippocampal place code
    Guifen Chen
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 110:378-83. 2013
    How do external environmental and internal movement-related information combine to tell us where we are? We examined the neural representation of environmental location provided by hippocampal place cells while mice navigated a virtual ..
  34. pmc Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, United Kingdom
    J Neurosci 32:10541-53. 2012
    ..Do they improve movement, and, if so, in what way? We acquired simultaneously magnetoencephalography and direct recordings from the ..
  35. ncbi Functional magnetic resonance imaging reveals the neural substrates of arm transport and grip formation in reach-to-grasp actions in humans
    Cristiana Cavina-Pratesi
    Department of Psychology, Durham University, Durham DH13LE, United Kingdom
    J Neurosci 30:10306-23. 2010
    ....
  36. ncbi Motor learning: its relevance to stroke recovery and neurorehabilitation
    John W Krakauer
    Stroke and Critical Care Division, Department of Neurology, Columbia University College of Physicians and Surgeons, New York NY, USA
    Curr Opin Neurol 19:84-90. 2006
    ..questions: (i) What is motor learning? (ii) Do patients with hemiparesis have a learning deficit? (iii) Is recovery after injury a form of motor learning? (iv) Are approaches based on motor learning principles useful for rehabilitation?..
  37. ncbi Oxygen uptake during whole-body vibration exercise: comparison with squatting as a slow voluntary movement
    J Rittweger
    Institut fur Physiologie, Freie Universitat Berlin, Germany
    Eur J Appl Physiol 86:169-73. 2001
    ..It is concluded that the increased metabolic power observed in association with VbX is due to muscular activity. It is likely that this muscular activity is easier to control between individuals than is simple squatting...
  38. pmc High-throughput ethomics in large groups of Drosophila
    Kristin Branson
    California Institute of Technology, Pasadena, California, USA
    Nat Methods 6:451-7. 2009
    ..We expect that our software, which permits high-throughput screening, will complement existing molecular methods available in Drosophila, facilitating new investigations into the genetic and cellular basis of behavior...
  39. ncbi Cortical mechanisms of human imitation
    M Iacoboni
    Brain Mapping Center, Neuropsychiatric Institute, Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095 7085, USA
    Science 286:2526-8. 1999
    ..To test this hypothesis, normal human participants were asked to observe and imitate a finger movement and to perform the same movement after spatial or symbolic cues...
  40. ncbi Neuromechanics of muscle synergies for posture and movement
    Lena H Ting
    W H Coulter Department of Biomedical Engineering, Emory University, Atlanta, GA 30332 0535, USA
    Curr Opin Neurobiol 17:622-8. 2007
    ..Understanding the complex interplay between neural circuits and biomechanics that give rise to muscle synergies will be crucial to advancing our understanding of neural control mechanisms for movement.
  41. pmc A central source of movement variability
    Mark M Churchland
    Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Neuron 52:1085-96. 2006
    ..When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control...
  42. ncbi Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex
    J K Chapin
    Department of Neurobiology and Anatomy, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Nat Neurosci 2:664-70. 1999
    ..With continued training in neurorobotic mode, the animals' lever movement diminished or stopped. These results suggest a possible means for movement restoration in paralysis patients.
  43. ncbi Imitation: is cognitive neuroscience solving the correspondence problem?
    Marcel Brass
    Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
    Trends Cogn Sci 9:489-95. 2005
    ..Imitation is based on the automatic activation of motor representations by movement observation. These externally triggered motor representations are then used to reproduce the observed behaviour...
  44. ncbi Compatibility between observed and executed finger movements: comparing symbolic, spatial, and imitative cues
    M Brass
    Department of Neurology, Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Brain Cogn 44:124-43. 2000
    Intuitively, one can assume that imitating a movement is an easier task than responding to a symbolic stimulus like a verbal instruction...
  45. ncbi Motor activation prior to observation of a predicted movement
    James M Kilner
    Institut des Sciences Cognitives, CNRS, 67 Boulevard Pinel, 69675 Bron, France
    Nat Neurosci 7:1299-301. 2004
    ..research has shown that some of the same motor regions are activated both when performing and when observing a movement. Here we demonstrate in human subjects that such motor activity also occurs prior to observing someone else's ..
  46. ncbi Movement-related changes in synchronization in the human basal ganglia
    Michael Cassidy
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
    Brain 125:1235-46. 2002
    ..This coupling was attenuated by movement. In the presence of exogenous dopaminergic stimulation, power within the STN and coherence between the STN and ..
  47. ncbi Cerebellar complex spikes encode both destinations and errors in arm movements
    S Kitazawa
    Information Science Division, Electrotechnical Laboratory, Japan Science and Technology Corporation, Tsukuba
    Nature 392:494-7. 1998
    ..We used information theory to show that the complex spikes occurring at the beginning of the reach movement encode the absolute destination of the reach, and the complex spikes occurring at the end of the short-lasting ..
  48. pmc Brain-computer interfaces: communication and restoration of movement in paralysis
    Niels Birbaumer
    Institute of Medical Psychology and Behavioural Neurobiology, University of Tuebingen, Tuebingen, Germany
    J Physiol 579:621-36. 2007
    ..locked-in patients with BCI communication after entering the complete locked-in state with no remaining eye movement failed...
  49. ncbi Central cancellation of self-produced tickle sensation
    S J Blakemore
    Wellcome Department of Cognitive Neurology, London, UK
    Nat Neurosci 1:635-40. 1998
    ..In the cerebellum, less activity was associated with a movement that generated a tactile stimulus than with a movement that did not...
  50. ncbi Influence of interhemispheric interactions on motor function in chronic stroke
    Nagako Murase
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Ann Neurol 55:400-9. 2004
    ..IHI) between M1(intact hemisphere) and M1(lesioned hemisphere) in the process of generation of a voluntary movement by the paretic hand in patients with chronic subcortical stroke and in healthy volunteers...
  51. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
    ..Learning to operate the BMIc was paralleled by functional reorganization in multiple cortical areas, suggesting that the dynamic properties of the BMIc were incorporated into motor and sensory cortical representations...
  52. ncbi CNS learns stable, accurate, and efficient movements using a simple algorithm
    David W Franklin
    ATR Computational Neuroscience Laboratories, Keihanna Science City, Kyoto 619 0288, Japan
    J Neurosci 28:11165-73. 2008
    ..This model of motor learning offers new insights as to how the brain controls the complex musculoskeletal system and iteratively adjusts motor commands to improve motor skills with practice...
  53. ncbi Movement intention after parietal cortex stimulation in humans
    Michel Desmurget
    Centre de Neuroscience Cognitive, CNRS, UMR 5229, 69500 Bron, France
    Science 324:811-3. 2009
    ..Yet, patients firmly denied that they had moved. Conscious intention and motor awareness thus arise from increased parietal activity before movement execution.
  54. ncbi Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
    ..In some tasks, these sensory errors are monitored and result in on-line corrective motor output as the movement progresses...
  55. ncbi Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa
    B Haslinger
    Neurologische Klinik, Neurozentrum Funktionelle Bildgebung, Klinikum rechts der Isar, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munchen, Germany
    Brain 124:558-70. 2001
    ..This allowed correlation of movement onset, i.e. event-onset, to scanning time...
  56. ncbi Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
    ..Overall, the laminar origins of neurons that interconnect the three cortical areas are typical of "lateral" interactions. Thus, from an anatomical perspective, this cortical network lacks a clear hierarchical organization...
  57. pmc Actin cable dynamics in budding yeast
    Hyeong Cheol Yang
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:751-6. 2002
    ..Analysis of movement of Abp140p-GFP fiduciary marks on bud-associated cables and fluorescence loss in photobleaching experiments ..
  58. ncbi Movement systems as dynamical systems: the functional role of variability and its implications for sports medicine
    Keith Davids
    School of Physical Education, University of Otago, Dunedin, New Zealand
    Sports Med 33:245-60. 2003
    In recent years, concepts and tools from dynamical systems theory have been successfully applied to the study of movement systems, contradicting traditional views of variability as noise or error...
  59. ncbi Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy
    Niels Fischer
    3D Electron Cryomicroscopy Group, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Nature 466:329-33. 2010
    ..Here we have followed tRNA movement through the ribosome during translocation by time-resolved single-particle electron cryomicroscopy (cryo-EM)...
  60. ncbi Perception of scene-relative object movement: Optic flow parsing and the contribution of monocular depth cues
    Paul A Warren
    School of Psychology and Communications Research Centre, Cardiff University, Cardiff, CF10 3AT Wales, UK
    Vision Res 49:1406-19. 2009
    ..its sensitivity to optic flow in order to parse retinal motion into components arising due to self and object movement (e.g. Rushton, S. K., & Warren, P. A. (2005)...
  61. ncbi An interference effect of observed biological movement on action
    J M Kilner
    Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron 69675, France
    Curr Biol 13:522-5. 2003
    ..Variance in the executed movement was measured as an index of interference to the movement...
  62. ncbi ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion--part I: ankle, hip, and spine. International Society of Biomechanics
    Ge Wu
    J Biomech 35:543-8. 2002
    ..There is currently a lack of standard for reporting joint motion in the field of biomechanics for human movement, and the JCS as proposed by Grood and Suntay has the advantage of reporting joint motions in clinically relevant ..
  63. ncbi Hand movement direction decoded from MEG and EEG
    Stephan Waldert
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 28:1000-8. 2008
    ..during center-out movements with the hand and found significant power modulation of MEG activity between rest and movement in three frequency bands: an increase for < or = 7 Hz (low-frequency band) and 62-87 Hz (high-gamma band) and ..
  64. ncbi Effects of masked stimuli on motor activation: behavioral and electrophysiological evidence
    M Eimer
    Department of Experimental Psychology, University of Cambridge, England
    J Exp Psychol Hum Percept Perform 24:1737-47. 1998
    ..A partial activation of the response corresponding to the prime was followed by a reverse activation pattern. It is argued that these effects primarily reflect an inhibition of the response initially triggered by the prime...
  65. pmc A movement ecology paradigm for unifying organismal movement research
    Ran Nathan
    Movement Ecology Laboratory, Department of Evolution, Systematics and Ecology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 105:19052-9. 2008
    b>Movement of individual organisms is fundamental to life, quilting our planet in a rich tapestry of phenomena with diverse implications for ecosystems and humans...
  66. pmc How each movement changes the next: an experimental and theoretical study of fast adaptive priors in reaching
    Timothy Verstynen
    Department of Physiology, Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    J Neurosci 31:10050-9. 2011
    ..phenomenon in which recent experience shapes the statistical properties of reaching, independent of any movement errors...
  67. pmc High-throughput behavioral analysis in C. elegans
    Nicholas A Swierczek
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Methods 8:592-8. 2011
    ..We examined three traditional behavioral paradigms using this system: spontaneous movement on food, where the behavior changes over tens of minutes; chemotaxis, where turning events must be detected ..
  68. ncbi Triple gene block: modular design of a multifunctional machine for plant virus movement
    Sergey Yu Morozov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    J Gen Virol 84:1351-66. 2003
    ..block' (TGB), a specialized evolutionarily conserved gene module involved in the cell-to-cell and long-distance movement of viruses...
  69. pmc Human control of an inverted pendulum: is continuous control necessary? Is intermittent control effective? Is intermittent control physiological?
    Ian D Loram
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester, UK
    J Physiol 589:307-24. 2011
    ..Recently, continuous, optimal control using internal models has emerged as a leading paradigm for voluntary movement. However, these engineering paradigms are designed for high band-width, inflexible, consistent systems whereas ..
  70. pmc Human medial frontal cortex mediates unconscious inhibition of voluntary action
    Petroc Sumner
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Neuron 54:697-711. 2007
    ..These findings imply that the SEF and SMA mediate automatic effector-specific suppression of motor plans. This automatic mechanism may contribute to the participation of these areas in the voluntary control of action...
  71. pmc Identification of new flagellar genes of Salmonella enterica serovar Typhimurium
    Jonathan Frye
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Bacteriol 188:2233-43. 2006
    ..Null alleles in cheV, mcpA, mcpB, mcpC, and srfB did not affect motility, while deletion of yhjH did result in reduced motility compared to that of the wild type...
  72. ncbi Ambulatory system for human motion analysis using a kinematic sensor: monitoring of daily physical activity in the elderly
    Bijan Najafi
    Swiss Federal Institute of Technology Lausanne, Institute for Biomedical Engineering, Laboratory of Motion Analysis and Measurement, 1015 Lausanne, Switzerland
    IEEE Trans Biomed Eng 50:711-23. 2003
    ..9% for "standing + walking," 4.1% for sitting, and 0.3% for lying. Finally, overall symmetric mean average errors were 12% for "standing + walking," 8.2% for sitting, and 1.3% for lying...
  73. pmc Direct control of paralysed muscles by cortical neurons
    Chet T Moritz
    Department of Physiology and Biophysics and Washington National Primate Research Center, University of Washington, Seattle, Washington 98195, USA
    Nature 456:639-42. 2008
    ..Such signals could then control electrical stimulation of muscles, thereby restoring volitional movement to paralysed limbs...
  74. ncbi Spatio-temporal prediction modulates the perception of self-produced stimuli
    S J Blakemore
    Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    J Cogn Neurosci 11:551-9. 1999
    ..First, we parametrically varied the delay between the movement of the left hand and the resultant movement of the tactile stimulus on the right hand...
  75. pmc iTUG, a sensitive and reliable measure of mobility
    Arash Salarian
    Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Federal de Lausanne, Lausanne, CH 1015 Lausanne, Switzerland
    IEEE Trans Neural Syst Rehabil Eng 18:303-10. 2010
    ..023). By repeating the tests for a second time, the test-retest reliability of iTUG was also evaluated. Among the subcomponents of iTUG, gait, turning, and turn-to-sit were the most reliable and sit-to-stand was the least reliable...
  76. ncbi Optimal spatial filtering of single trial EEG during imagined hand movement
    H Ramoser
    Department of Medical Informatics, Institute of Biomedical Engineering, Graz University of Technology, Austria
    IEEE Trans Rehabil Eng 8:441-6. 2000
    ..g., associated with imaginary movement. One-sided hand movement imagination results in EEG changes located at contra- and ipsilateral central areas...
  77. ncbi Movement smoothness changes during stroke recovery
    Brandon Rohrer
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 22:8297-304. 2002
    ..We used a robotic therapy device to analyze five different measures of movement smoothness in the hemiparetic arm of 31 patients recovering from stroke...
  78. pmc Decoding complete reach and grasp actions from local primary motor cortex populations
    Carlos E Vargas-Irwin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 30:9659-69. 2010
    ..neural activity in primary motor cortex (M1) of macaques (Macaca mulatta) to arm, wrist, and hand postures during movement. We find that the firing rate of individual M1 neurons is typically modulated by the kinematics of multiple ..
  79. ncbi Exercise induces angiogenesis but does not alter movement representations within rat motor cortex
    Jeffrey A Kleim
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alberta T1K 3M4, Canada
    Brain Res 934:1-6. 2002
    The effects of exercise on the topography of movement representations and blood vessel density within the rat forelimb motor cortex was examined...
  80. ncbi Cross-talk between language processes and overt motor behavior in the first 200 msec of processing
    Véronique Boulenger
    CNRS UMR, 5015 Institut des Sciences Cognitives, Bron Cedex, France
    J Cogn Neurosci 18:1607-15. 2006
    ..issue by examining the influence of processing action verbs and concrete nouns on the execution of a reaching movement. Fine-grained analyses of movement kinematics revealed that relative to nouns, processing action verbs ..
  81. ncbi Human parietal "reach region" primarily encodes intrinsic visual direction, not extrinsic movement direction, in a visual motor dissociation task
    Juan Fernandez-Ruiz
    Canadian Institutes of Health Research Group on Action and Perception, and Centre for Vision Research, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Cereb Cortex 17:2283-92. 2007
    ..It is not known if these representations encode the visual goal in retinal coordinates, or the movement direction relative to gaze...
  82. ncbi Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes
    Shunsuke Kimura
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Cell Struct Funct 33:109-22. 2008
    ..After formation, autophagosomes show a rapid vectorial movement in the direction of the centrosome, where lysosomes are usually concentrated...
  83. ncbi Cross-modal plasticity of the motor cortex while listening to a rehearsed musical piece
    A D'Ausilio
    Institut für Medizinische Psychologie und Verhaltensneurobiologie, Eberhard Karls Universitat Tubingen, Gartenstrasse 29, D 72074 Tubingen, Germany
    Eur J Neurosci 24:955-8. 2006
    ..Moreover, we observed an increase of excitability over time as intracortical facilitation was already present after 30 min of training whereas cortico-spinal facilitation increased after a longer training period (5 days)...
  84. ncbi A neural basis for motor primitives in the spinal cord
    Corey B Hart
    Neurobiology and Anatomy, College of Medicine and School of Bioengineering and Health Sciences, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:1322-36. 2010
    Motor primitives and modularity may be important in biological movement control. However, their neural basis is not understood...
  85. ncbi Direct visuomotor transformations for reaching
    Christopher A Buneo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Nature 416:632-6. 2002
    ..This function is supported by findings that PPC neurons in monkeys are modulated by the direction of hand movement, as well as by visual, eye position and limb position signals...
  86. ncbi Spectral changes in cortical surface potentials during motor movement
    Kai J Miller
    Department of Physics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 27:2424-32. 2007
    In the first large study of its kind, we quantified changes in electrocorticographic signals associated with motor movement across 22 subjects with subdural electrode arrays placed for identification of seizure foci...
  87. ncbi Binding of movement, sound and touch: multimodal coordination dynamics
    J Lagarde
    Laboratory Efficience Deficience Motrice, University Montpellier 1, 700 Avenue Pic Saint Loup, 34090 Montpellier, France
    Exp Brain Res 173:673-88. 2006
    Very little is known about the coordination of movement in combination with stimuli such as sound and touch. The present research investigates the hypothesis that both the type of action (e.g...
  88. ncbi Sequential activation of motor cortical neurons contributes to intralimb coordination during reaching in the cat by modulating muscle synergies
    Sergiy Yakovenko
    Departement de Physiologie, Universite de Montreal, Pavillon Paul G Desmarais, C P 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Neurophysiol 105:388-409. 2011
    ....
  89. ncbi Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders
    R C M Philip
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychol Med 40:1919-29. 2010
    ..To date, however, no studies have examined emotion processing in autism across a broad range of social signals...
  90. ncbi The coordination of movement: optimal feedback control and beyond
    Jorn Diedrichsen
    Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queens Square, London, UK
    Trends Cogn Sci 14:31-9. 2010
    ..We highlight two crucial areas of research, hierarchical control and the problem of movement initiation, that need to be developed for an optimal feedback control theory framework to characterise movement ..
  91. ncbi Motor learning is optimally tuned to the properties of motor noise
    Robert J van Beers
    Department of Physics of Man, Helmholtz Institute, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Neuron 63:406-17. 2009
    In motor learning, our brain uses movement errors to adjust planning of future movements. This process has traditionally been studied by examining how motor planning is adjusted in response to visuomotor or dynamic perturbations...
  92. ncbi Functional mapping of human sensorimotor cortex with electrocorticographic spectral analysis. I. Alpha and beta event-related desynchronization
    N E Crone
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain 121:2271-99. 1998
    ..Sometimes, unilateral limb movement produced sustained alpha and beta ERD over bilateral sensorimotor cortices, with overlapping patterns for ..
  93. ncbi A randomized controlled trial of movement strategies compared with exercise for people with Parkinson's disease
    Meg E Morris
    School of Physiotherapy, The University of Melbourne, Australia
    Mov Disord 24:64-71. 2009
    This randomized controlled clinical trial was conducted to compare the effects of movement rehabilitation strategies and exercise therapy in hospitalized patients with idiopathic Parkinson's disease...
  94. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
    ..This suggests that the motor system requires that planned and executed trajectories remain congruous in visual space, and enforces this correspondence even at the expense of an opposing explicit task goal...
  95. pmc Restoration of grasp following paralysis through brain-controlled stimulation of muscles
    C Ethier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nature 485:368-71. 2012
    ..spinal cord injury lack the connections between brain and spinal cord circuits that are essential for voluntary movement. Clinical systems that achieve muscle contraction through functional electrical stimulation (FES) have proven to ..
  96. pmc Boosting cortical activity at Beta-band frequencies slows movement in humans
    Alek Pogosyan
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK
    Curr Biol 19:1637-41. 2009
    ..It is manifest during the maintenance of tonic contractions and is suppressed prior to and during voluntary movement. This and other correlative evidence suggests that beta activity might promote tonic contraction, while impairing ..
  97. ncbi Understanding movement data and movement processes: current and emerging directions
    Robert S Schick
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC 27708 0328, USA
    Ecol Lett 11:1338-50. 2008
    Animal movement has been the focus on much theoretical and empirical work in ecology over the last 25 years...
  98. ncbi Decoupling the cortical power spectrum reveals real-time representation of individual finger movements in humans
    K J Miller
    Department of Physics, Seattle Children s Research Institute and Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 29:3132-7. 2009
    During active movement the electric potentials measured from the surface of the motor cortex exhibit consistent modulation, revealing two distinguishable processes in the power spectrum...
  99. ncbi When feeling is more important than seeing in sensorimotor adaptation
    Robert J van Beers
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, WC1N 3AR, London, United Kingdom
    Curr Biol 12:834-7. 2002
    ..These results provide evidence for statistically optimal integration of information from multiple modalities...
  100. ncbi Cortical control of arm movements: a dynamical systems perspective
    Krishna V Shenoy
    Department of Electrical Engineering, Stanford Institute for Neuro Innovation and TranslationalNeuroscience, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 36:337-59. 2013
    Our ability to move is central to everyday life. Investigating the neural control of movement in general, and the cortical control of volitional arm movements in particular, has been a major research focus in recent decades...
  101. ncbi Perceiving affect from arm movement
    F E Pollick
    Department of Psychology, Glasgow University, 58 Hillhead Street, Glasgow G12 8QB, UK
    Cognition 82:B51-61. 2001
    ..and scrambled movements Dimension 1 of the psychological space was highly correlated to the kinematics of the movement. These results suggest that the corresponding activation of perceived affect is a formless cue that relates ..

Research Grants83

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: Internal Monitoring of Eye Movement in Schizophrenia Number: 10-EI-0016 Summary: Background: - Researchers are studying how humans are able to move ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: Internal Monitoring of Eye Movement in Schizophrenia Number: 10-EI-0016 Summary: Background: - Researchers are studying how humans are able to move ..
  3. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..and blunted hypercapnic ventilatory responsiveness in persons with tetraplegia, which are also normal rapid eye movement (REM) sleep phenomena, could predispose to greater apnea severity and potentiate falls in cardiac output similar ..
  4. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..Specific Aim 1 involves eye movement recordings in the CACNA1A mutant tottering, and in normal mice following pharmacological inhibition of the ..
  5. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..This is intriguing because the brain makes dopamine from the amino acid tyrosine. The movement of tyrosine across cell membranes is abnormal in schizophrenia...
  6. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..will be obtained will be of general value in understanding the genetic structure of the extrapyramidal system which in turn will help our understanding of movement disorders that are prevalent in the VA population, such a Parkinsonism.
  7. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..We also ask how the intra-store calcium determines how much will move, or when the movement will cease. Therefore, our work should help understand why signals fail, or get out of hand...
  8. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid residues as suggested by molecular ..
  9. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid residues as suggested by molecular ..
  10. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a neurodegenerative movement disorder which affects 5% of the world population over the age of 85 and may affect some individuals as young as 40. More than 15,000 U.S...
  11. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..compounds would next be evaluated for functionality by assessing their ability to impair chemotaxis (cellular movement) in vitro, a process that is mediated by CCR7...
  12. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..is required, yet in the past this has often failed to separate real neurological disorder from artifacts such as movement, eye blinks, and cardiac signals...
  13. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Studying the untoward effects of mutant ET genes will increase our knowledge of ET and other movement disorders such as Parkinson disease.
  14. Computer/Electrical Engineering
    Theodore Raphan; Fiscal Year: 2011
    ..This will also be used in human locomotion experiments. 6. Modify the eye movement recording system for monkey locomotion, which now records only one eye, to be binocular so the point of fixation ..
  15. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..The rationale for the proposed research is that once the roles of SGCE in causing dysfunction of movement control in the brain are determined, possible interventions to correct M-D can be developed...
  16. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..Changes in the following variables will be evaluated: balance, strength, active range of movement per joint, coordination, hand and shoulder function, and compared across groups, matching for injury level as ..
  17. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..aureus by colonized farmers to close family contacts, in order to determine movement of organisms to individuals lacking occupational exposure...
  18. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..will be measured in the trachea and nasopharynx of 3, 6, 12, and 24 month old C57BL/6 mice by tracking the movement of endogenous mucus particles or instilled fluorescent beads. Specific aim 2...
  19. Growth Hormone Regulation of SH2B1
    Christin Carter-Su; Fiscal Year: 2013
    ..The objective of the current proposal is to understand how SH2B1 regulates assembly and movement of "signaling complexes" and whether dysregulation of these functions contributes to defects in cellular function ..
  20. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..The progressive loss of nigrostriatal DA neurons gradually leads to a severe movement disorder characterized by tremor, rigidity, bradykinesia and impaired balance...
  21. SYSTEM FOR AUTOMATED NONINVASIVE MONITORING OF MOUSE SLEEP AND BEHAVIOR
    Sridhar Sunderam; Fiscal Year: 2013
    ..Abnormal sleep patterns can manifest as a variety of disorders-sleep apnea, parasomnias, REM (rapid eye movement sleep) behavioral disorder (RBD), narcolepsy-many of which are influenced by heredity...
  22. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..g. PC12 neurites, to see if the kinetics are similar;4) to measure the movement of melanosomes (which are non-fluorescent), using bright-Field Imaging with One Nanometer Accuracy (bFIONA), a ..
  23. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..While loss of substantia nigra dopaminergic neurons is primarily responsible for the characteristic parkinsonian movement disorder, non-motor disabilities including dementia, depression, gastrointestinal dysfunction, and autonomic ..
  24. Moffitt Skin Cancer SPORE
    Jeffrey S Weber; Fiscal Year: 2013
    ..melanoma and non-melanoma skin cancer will work with an outstanding group of basic scientists to accelerate the movement of ideas out of the laboratory to the clinic...
  25. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..suffering and death, the consequences may include the spread of cancer to lymph nodes as well as chemokine-driven movement of specialized ("dendritic") immune cells to the nodes, which in turn can promote immune "tolerance" to the tumor...
  26. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    A great many biological energy transduction pathways depend upon the rapid movement of electrons or holes over long distances (>30 [unreadable]) through proteins...
  27. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..Since the target, Rac2 Rho GTPase is responsible for cell movement PLD2 might be a major GEF mediating chemotaxis...
  28. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta (SNc) and the associated deficiency of the neurotransmitter dopamine ..
  29. Glutathione in mitochondrial dysfunction and disease progression in ALS-models
    Marcelo R Vargas; Fiscal Year: 2011
    ..ALS) or Lou Gehrig's disease is characterized by the specific death of the nerve cells that control muscle movement, leading to paralysis and eventual death...
  30. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..We will investigate how oxidized lipids block the movement of endothelial cells (cells that normally line blood vessels) into an area of injury or onto a bypass graft...
  31. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..This shows that FAK catalytic activity is not essential for MEF proliferation-survival, but is required for cell movement in vitro and in vivo. To extend these findings, we propose 3 research aims...
  32. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..to maintain the timely "opening" and "closing" of the BTB during spermatogenesis while facilitating germ cell movement across the barrier...
  33. Activity Dependent Signaling in Adult Skeletal Muscle Fiber Plasticity
    Martin F Schneider; Fiscal Year: 2012
    ..Our aims will be: (1) To characterize the molecular determinants for movement of the transcription factor NFAT, an activator of slow fiber type genes, into muscle fiber nuclei and into ..
  34. Anti-inflammatory effects of colitis-induced changes in commensal gut microbes
    JONATHAN JAMES HANSEN; Fiscal Year: 2013
    ..also upregulate expression of acid resistance genes, gadA and gadB, during colitis and that these genes inhibit movement of the bacteria into intestinal tissues and prevent killing of E. coli by macrophages...
  35. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    ..and Shigella, enhancing evasion of the host innate immune system and facilitating inter- and intracellular movement. Therefore, broad spectrum inhibitors of this protease family will have multiple therapeutic applications, both ..
  36. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..We hypothesize that understanding HXA3/MRP2 based signaling, which directs the movement of PMNs across the intestinal epithelium, will lead to the development of important therapeutics designed to help ..
  37. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2012
    ..motile cells are guided along a particular path, they recognize guidance cues and translate them into directed movement. Finally, cells must be able to recognize their target tissue and stop migrating and cells that fail to reach ..
  38. Glial-neuronal interactions underlying the molecular feedback between HIV viral p
    Sulie L Chang; Fiscal Year: 2013
    ..and that these animals have greater METH-induced behavioral sensitization, as assessed by stereotypical head movement. Based on the literature and our previous data, we hypothesize that the abuse of substances, such as METH, in the ..
  39. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary torsion dystonias (PTD) are a group of movement disorders characterized by twisting muscle contractures, with dystonia as the only clinical sign (except for tremor) and in the absence of ..
  40. Structural mechanism of DNA segregation by the pSK41 par system
    Maria Schumacher; Fiscal Year: 2010
    ..Essential to this process are the accurate movement and positioning of chromosomes and plasmids to daughter cells at cell division...
  41. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..This region is also involved in control of voluntary movement and habitual behavior, and is also under the control of a chemical messenger known as dopamine...
  42. In vivo analysis of the mechanisms of axon transport.
    Catherine M Drerup; Fiscal Year: 2011
    ..zebrafish as an in vivo model for studying axon transport by 1) developing a novel imaging approach to visualize movement of fluorescently labeled cargo in an intact animal;and 2) participating in a forward genetic screen to isolate ..
  43. Multi-Organ Autonomic Electrophysiology in Parkinson Disease
    Samay Jain; Fiscal Year: 2013
    ..D., M.S. is a junior faculty member in the University of Pittsburgh, Department of Neurology Movement Disorders Division since 2006. In 2007, Dr...
  44. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..applies spatially and temporally stereotyped patterns of electrical activation to peripheral nerves to achieve movement restoration in spinal cord injured (SCI) persons...
  45. COCHLEAR MACROPHAGES AND EPITHELIAL REPAIR
    Keiko Hirose; Fiscal Year: 2013
    ..Using this technique, we can follow the movement and activity of macrophages to determine how they interact with hair cells in ototoxic injury...
  46. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Lastly, sphingomyelin, which has been shown to inhibit sPLA2 activity, inhibits the SAA- mediated movement of cholesterol to the ER...
  47. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..processes including regulation of electrical excitability of nerve and muscle cells, modulation of salt and water movement across epithelia and acidification of intracellular compartments...
  48. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Defects of mitochondrial shaping and movement underlie many neurodegenerative diseases and may be associated with premature aging as well as infertility...
  49. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..Acetylcholine (ACh) plays a key role in generating the rapid eye movement (REM) phase of sleep, and REM sleep abnormalities typify some forms of depression...
  50. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..govern critical cellular processes such as signal transduction, transcription, mitosis, cell shape and cell movement by acting as molecular switches that regulate activity of protein partners...
  51. VOLTAGE SENSITIVE SODIUM CHANNELS IN BRAIN
    William A Catterall; Fiscal Year: 2013
    ..by applicant): Electrical signaling is a nearly universal process in cell physiology, initiating and controlling movement, secretion, enzyme activity, and gene expression...
  52. Drug Transport at the Blood-Testis Barrier
    Nathan J Cherrington; Fiscal Year: 2013
    ..Selective movement of compounds across Sertoli cells therefore comprises the physiologic or functional aspect of the BTB...
  53. Germ Cell Migration in Drosophila.
    Ruth Lehmann; Fiscal Year: 2013
    ..motile cells are guided along a particular path, they recognize guidance cues and translate them into directed movement. Finally, cells must be able to recognize their target tissue and stop migrating and cells that fail to reach ..
  54. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    6. Project Summary/Abstract Neurotransmitter:sodium symporters (NSS) couple the accumulation of substrate to the movement of sodium ions down their concentration gradient across the plasma membrane, and as such constitute key elements in ..
  55. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..In addition to our battery of existing measurements of respiration, heart rate, blood pressure, movement, EEG and temperature, we propose to incorporate new state of the art measures of venous return and tissue ..
  56. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2013
    Project Summary Ion channels and transporters control the movement of charged ions across cell membranes...
  57. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher E Turner; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: ll movement is essential for normal processes such as embryonic development and tissue repair but it is also a key factor in ..
  58. The Effect Of Deafness Associated Mutations on MyosinVIIA Function
    Eva Forgacs; Fiscal Year: 2010
    ..molecule motility measurements, fluorescently labeled CaM light chain will be added to the myosin VIIA and the movement of the molecule will be measured by Total Internal Reflection Fluorescence microscopy (TIRF)...
  59. The role of the orphan receptor tyrosine kinase Ros1 in vascular disease
    ZIAD ANWAR ALI; Fiscal Year: 2011
    ..has directed us to a receptor without a known activator, Ros1, which is involved in cell division, growth, movement and death;processes all involved in atherosclerosis...
  60. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
    ..motility is increased in cells expressing active PMR1, and the experiments in Aim 3 will use imag- ing of cell movement, quantitative PCR and immunofluorescence to examine the relationship between motility, PMR1 binding to the Ena/..
  61. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ..15-LOX product of AA, namely, 15(S)-HETE via its capacity to perturb EC barrier function promotes paracellular movement of inflammatory cells into sub-endothelial space and sets the soil for the development of atherosclerosis...
  62. Prophage-associated virulence factors in pathogenic Neisseria species
    ANNA KARLS; Fiscal Year: 2009
    ..Defining the mechanism for the movement of the phage DNA is essential to understanding the role of the phage in GC and MC pathogenesis...
  63. REACTION MECHANISM OF MYOCARDIAC UBIQUINONE-PROTEINS
    Chang An Yu; Fiscal Year: 2009
    ..9 A resolution and indicated that QCR is a functional dimer and that the catalytic cycle of the complex involves movement of the head domain of iron-sulfur protein (ISP)...
  64. Visualization of Pelvic Floor Reflexes
    CHRISTOS EURIPIDES CONSTANTINOU; Fiscal Year: 2010
    ..b>Movement detection, including motion tracking algorithms and segmentation algorithms will be developed to acquire new ..
  65. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2007
    ..plegic stroke victims using a novel therapeutic regimen and robotic device called "AMES," an acronym for Assisted Movement with Enhanced Sensation...
  66. EMG Biofeedback with AMES
    Paul Cordo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The long-range goal of this project is to restore functional movement to low-functioning stroke patients using a novel therapeutic regimen and robotic device called "AMES," an acronym for Assisted ..
  67. NEURAL NETWORK MODELING OF SPEECH PRODUCTION
    Frank Guenther; Fiscal Year: 2000
    ..mechanism that allows synthesis of speech wave-forms and an acoustic-like coordinate frame for speech movement planning...
  68. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    DESCRIPTION (modified from the principal investigator's application): Involuntary movement disorders are a major cause of disability...
  69. BASAL GANGLIA CONTROL OF POSTURE AND MOVEMENT
    Jonathan Mink; Fiscal Year: 1999
    ..forebrain, diencephalon, and midbrain that are thought to play a significant role in the control of posture and movement. It is well known that human patients with certain degenerative diseases of the basal ganglia (e.g...
  70. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    DESCRIPTION (provided by applicant: Dystonia is a movement disorder defined as a syndrome of sustained muscle contractions, causing twisting and repetitive movements, and abnormal postures...
  71. Restoring upper limb movement sense to amputees;a move towards natural control o
    Paul Marasco; Fiscal Year: 2012
    ..in 3 Aims focused on developing and implementing approaches to harness and utilize a cognitive illusion of limb movement in human amputees with targeted sensory reinnervation...
  72. Changes in Control of Movement Timing and Stability With Muscle Fatigue
    JONATHAN DINGWELL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Work-related musculoskeletal injuries have been linked to movement repetition, improper postures, and muscle fatigue...
  73. MaqFACS: Measuring expressive movement in monkeys
    Lisa Parr; Fiscal Year: 2009
    ..To date there is no methodology for quantifying these movement deficits in a monkey, not to mention a means with which these deficits may be compared to those that characterize ..
  74. ON-OFF MOOD CHANGE IN PARKINSONS DISEASE
    Kevin Black; Fiscal Year: 2000
    ..past clinical and research experience to a productive research career focused on the functional neuroanatomy of movement disorders...
  75. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Diseases affecting the basal ganglia produce a variety of movement deficits, and these deficits are often totally disabling. Parkinson's disease, which affects about 1...
  76. BASAL GANGLIA GENE EXPRESSION AND MOVEMENT DISORDERS
    Kalpana Merchant; Fiscal Year: 1993
    ..The APD-induced movement disorders are clinically indistinguishable from their idiopathic counterparts...
  77. Field Measures of Functional Tasks for CIT Intervention
    Paolo Bonato; Fiscal Year: 2006
    DESCRIPTION (provided by the applicant): Paresis of the upper limb after stroke results in limited functional movement ability for many patients...
  78. HAL: A TOOL FOR ASSESSING HUMAN ACTION IN THE WORKPLACE
    JOHN ALOIMONOS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Human movement has been a large window into the functioning of the nervous system...
  79. High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia in
    LELAND DIBBLE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Idiopathic Parkinson disease (IPD) is the model movement disorder to explore the motor function of the basal ganglia...
  80. Medial Collapse Movement Impairments associated with Patellofemoral Pain
    GRETCHEN SALSICH; Fiscal Year: 2009
    ..One recently proposed factor contributing to increased patellofemoral joint stress is a movement impairment consisting of medial collapse of the lower extremity during weightbearing...
  81. STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY
    Eric C Hartman; Fiscal Year: 2010
    ..stimulation and a servomotor drive such that the prescribed exercise range of motion is fulfilled with each movement cycle...
  82. Sensor Network for Monitoring Real-world Arm Activity of Rehabilitation Patients
    Gitendra Uswatte; Fiscal Year: 2010
    ..The PI's research group and others have employed accelerometers, sensors that detect movement, to objectively measure the amount of upper- extremity activity in the community among brain injury survivors...
  83. Individual Predoctoral Dental Scientist Fellowship
    Cameron Walker; Fiscal Year: 2009
    While orthodontic tooth movement occupies a prominent position in clinical dentistry, teeth are capable of extensive movement and displacement without the use of orthodontic appliances...