Research Topics
Genomes and Genes | tissue distributionSummarySummary: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
G G Kuiper
Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
Endocrinology 138:863-70. 1997..The rat tissue distribution and/or the relative level of ER alpha and ER beta expression seems to be quite different, i.e...Drug delivery systems: entering the mainstream
Theresa M Allen
Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
Science 303:1818-22. 2004..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
Daniel Globisch
Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
PLoS ONE 5:e15367. 2010..Additionally, we show using HPLC-MS analysis and immunohistochemistry that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS...Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
Wim H De Jong
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Biomaterials 29:1912-9. 2008A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...Factors affecting the clearance and biodistribution of polymeric nanoparticles
Frank Alexis
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Pharm 5:505-15. 2008....Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
Nikolai Khlebtsov
Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
Chem Soc Rev 40:1647-71. 2011....Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
Yin Meng Tsai
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
Int J Pharm 416:331-8. 2011..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
Yong Soon Kim
Korea Environment and Merchandise Testing Institute, Incheon, Korea
Inhal Toxicol 20:575-83. 2008..Nonetheless, the tissue distribution of silver nanopaticles did show a dose-dependent accumulation of silver content in all the tissues examined...Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
Jun Wang
Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
Int J Nanomedicine 5:861-6. 2010This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.Recent advances in iron oxide nanocrystal technology for medical imaging
Claire Corot
Guerbet Research, BP 57400, 95943 Roissy CDG, France
Adv Drug Deliv Rev 58:1471-504. 2006..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...Toxic potential of materials at the nanolevel
Andre Nel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
C Lasagna-Reeves
Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
Biochem Biophys Res Commun 393:649-55. 2010..The results indicate that tissue accumulation pattern of GNPs depend on the doses administered and the accumulation of the particles does not produce sub-acute physiological damage...Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
Suresh K Balasubramanian
Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
Biomaterials 31:2034-42. 2010..These results demonstrate that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs...Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats
S Takenaka
Institute for Inhalation Biology, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
Environ Health Perspect 109:547-51. 2001....Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
A H Schinkel
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
Cell 77:491-502. 1994....Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
Wan Seob Cho
Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
Toxicol Appl Pharmacol 236:16-24. 2009..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Zhuang Liu
Nat Nanotechnol 2:47-52. 2007The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
D M Stone
Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
Nature 384:129-34. 1996..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
Wolfgang G Kreyling
Helmholtz Center Munich, Neuherberg Munich, Germany
Inhal Toxicol 21:55-60. 2009..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
J D Wadsworth
MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
Lancet 358:171-80. 2001..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
Parag Aggarwal
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Adv Drug Deliv Rev 61:428-37. 2009..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution...The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
Sharmilee Gnanapavan
Department of Endocrinology, St Bartholomew s and The Royal London Hospital, London ECIA 7BE, UK
J Clin Endocrinol Metab 87:2988. 2002..GHS-R1b expression was also widespread in all tissues studied. The significance of the widespread tissue distribution of ghrelin remains to be determined...Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery
Giulio F Paciotti
CytImmune Sciences, Inc, College Park, Maryland 20740, USA
Drug Deliv 11:169-83. 2004..Finally, PT-cAu-TNF was less toxic and more effective in reducing tumor burden than native TNF since maximal antitumor responses were achieved at lower doses of drug...Identification of tissue-specific microRNAs from mouse
Mariana Lagos-Quintana
Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
Curr Biol 12:735-9. 2002..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase
Jeong Han Kang
Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
Eur J Biochem 271:2452-61. 2004..The mRNA master dot-blot for multiple human tissues provided a complete map of the tissue distribution not only for PNPO but also for pyridoxal kinase and pyridoxal phosphatase...A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development
Michio Sone
Department of Cell Biology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
Cell Stress Chaperones 18:307-19. 2013..Unexpected glial IRE1/XBP1 activity may provide us with novel insights into the brain homeostasis regulated by the UPR...Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
J F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...Rapid translocation of nanoparticles from the lung airspaces to the body
Hak Soo Choi
Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nat Biotechnol 28:1300-3. 2010..We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis...Biodistribution and toxicity of intravenously administered silica nanoparticles in mice
Guangping Xie
Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Arch Toxicol 84:183-90. 2010..Here we investigated the long-term (30 days) quantitative tissue distribution, and subcellular distribution, as well as potential toxicity of two sizes of intravenously administered ..Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats
Daniëlle Pk Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
Nanomedicine (Lond) 6:339-49. 2011..To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications...A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
F A L M Eskens
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
Br J Cancer 98:80-5. 2008..No partial or complete responses were observed, stable disease lasting more than four cycles was seen in seven patients. The recommended dose for studies with BIBW 2992 for 14 days followed by 14 days off medication is 70 mg OD...Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
Itai Yanai
Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
Bioinformatics 21:650-9. 2005..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
Nikki Parker
Endocyte Inc, West Lafayette, IN 47906, USA
Anal Biochem 338:284-93. 2005..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...CSF as a surrogate for assessing CNS exposure: an industrial perspective
Jiunn H Lin
Department of Preclinical Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania, USA
Curr Drug Metab 9:46-59. 2008..Depending on the physicochemical properties of drugs and the site/timing of CSF sampling, the unbound drug concentration at the biophase within the brain could differ significantly from the corresponding CSF drug concentration...Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats
Jun Ho Ji
Samsung Electronics Co Ltd, Suwon, Korea
Inhal Toxicol 19:857-71. 2007....Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
Margareta Hammarlund-Udenaes
Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Basic Clin Pharmacol Toxicol 106:215-20. 2010..However, there is an urgent need to collect more relevant data for predicting active site concentrations in tissues with active transporters in their plasma membranes...Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
Ronald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005..Distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra...Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study
Jimena Cazenave
Universidad Nacional de Cordoba, Facultad de Ciencias Exactas, Fisicas y Naturales, Cátedra Diversidad Animal II, Velez Sarsfield 299, 5000 Cordoba, Argentina
Aquat Toxicol 75:178-90. 2005..These findings also raise questions on the probable neurotoxicity of microcystins...Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
Ganeshchandra Sonavane
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Colloids Surf B Biointerfaces 66:274-80. 2008..The results revealed that tissue distribution of gold nanoparticles is size-dependent with the smallest 15 nm nanoparticles showing the most widespread ..Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
O Braissant
Institut de Biologie Animale, , , Switzerland
Endocrinology 137:354-66. 1996..PPAR-gamma is expressed predominantly in adipose tissue and the immune system. Our results suggest new potential directions to investigate the functions of the different PPAR subtypes...Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
Jonathan D Turner
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
J Mol Endocrinol 35:283-92. 2005....Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection
P Laverman
Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Pharmacol Exp Ther 298:607-12. 2001..Therefore, these findings may have a considerable impact on the clinical application of liposomal formulations that are administered repeatedly...Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats
Holger Fuchs
Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Birkendorfer Str 65, 88397 Biberach Riss, Germany
Biopharm Drug Dispos 30:229-40. 2009..In order to test these hypotheses, the tissue distribution of BI 1356 was determined in wild-type and DPP-4 deficient rats at different dose levels by means of whole ..Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles
Rochelle R Arvizo
Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, Rochester, Minnesota, United States of America
PLoS ONE 6:e24374. 2011....Size and shape effects in the biodistribution of intravascularly injected particles
P Decuzzi
Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
J Control Release 141:320-7. 2010..as the diameter d increases, suggesting the use of smaller particles to provide a more uniform tissue distribution. However, discoidal particles have been observed to accumulate more than others in most of the organs but ..The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
Minjung Cho
Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
Toxicol Lett 189:177-83. 2009..and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo...Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
Alexandra Aicher
Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
Circulation 107:2134-9. 2003..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals...PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
Yuta Yoshizawa
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
Int J Pharm 412:132-41. 2011..These results suggest that PEG liposome would serve as a potent PTX delivery vehicle for the future cancer chemotherapy...Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction
Won Jun Kang
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
J Nucl Med 47:1295-301. 2006..The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG.Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration
Cheng Feng Luo
The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510260, China
Int J Pharm 410:138-44. 2011..The objective of this study was to investigate the pharmacokinetics, tissue distribution and relative bioavailability of puerarin in rats after a single dose intragastric administration of ..Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions
Lei Gao
Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China
Int J Pharm 355:321-7. 2008The purpose of the present study was to investigate the effects of particle size on the pharmacokinetics and tissue distribution of oridonin nanosuspensions after intravenous administration...Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging
K H Lee
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Nucl Med Commun 24:1003-9. 2003..Thus, substrate availability should be considered as a potential limiting factor for photon emission efficiency in certain organs when attempting quantitative interpretation of optical luc gene imaging...Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
M J Egorin
Division of Developmental Therapeutics, University of Maryland Cancer Center, Baltimore, MD 21201, USA
Cancer Chemother Pharmacol 47:291-302. 2001..Studies were performed in mice to: (1) define the plasma pharmacokinetics, tissue distribution, and urinary excretion of 17AAG after i.v. delivery; (2) to define the bioavailability of 17AAG after i.p...Biomagnification in marine systems: the perspective of an ecologist
John S Gray
Department of Biology, University of Oslo, Norway
Mar Pollut Bull 45:46-52. 2002..Finally suggestions are made as to how data can be collected to better interpret the process of biomagnification in marine food webs...Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
Jianjun Cheng
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Biomaterials 28:869-76. 2007..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice
Guodong Zhang
Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Biomaterials 30:1928-36. 2009..Thus, 20-nm AuNPs coated with TA-terminated PEG(5000) are promising potential drug delivery vehicles and diagnostic imaging agents...The kinetics of the tissue distribution of silver nanoparticles of different sizes
D P K Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Biomaterials 31:8350-61. 2010Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation
B S Kwon
Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 272:14272-6. 1997..A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation...Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
Y Coulouarn
European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
FEBS Lett 457:28-32. 1999..In situ hybridization histochemistry showed that the prepro-UII gene is predominantly expressed in motoneurons of the brainstem and spinal cord, suggesting that UII may play a role in the control of neuromuscular functions...P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
A H Schinkel
The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
J Clin Invest 97:2517-24. 1996..b>Tissue distribution studies demonstrated that the relative brain penetration of radiolabeled ondansetron and loperamide (and ..Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
Noriyuki Maeda
Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
J Control Release 100:41-52. 2004..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
Jasmine P Davda
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int Immunopharmacol 8:401-13. 2008..The model gave satisfactory predictions of CC49 disposition and tumor uptake in man...Axon tracts correlate with netrin-1a expression in the zebrafish embryo
J D Lauderdale
Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
Mol Cell Neurosci 9:293-313. 1997..These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways...Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
Henrik Nordman
Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
Biochem J 364:191-200. 2002..Following ion-exchange HPLC, both MUC5AC and MUC6 appeared as several distinct populations, probably corresponding to 'glycoforms' of the mucins, the most highly charged of which were found in the gland tissue...Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours
Andreas Helisch
Department of Nuclear Medicine, University of Mainz, Mainz, Germany
Eur J Nucl Med Mol Imaging 31:1386-92. 2004....Interferon gamma induction of pulmonary emphysema in the adult murine lung
Z Wang
Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
J Exp Med 192:1587-600. 2000..IFN-gamma causes emphysema and alterations in pulmonary protease/antiprotease balance when expressed in pulmonary tissues...Anti-inflammatory properties of cerium oxide nanoparticles
Suzanne M Hirst
Center for Molecular Medicine and Infectious Diseases CMMID, 1410 Prices Fork Blacksburg, VA 24060, USA
Small 5:2848-56. 2009..Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation...Probing microRNAs with microarrays: tissue specificity and functional inference
Tomas Babak
Banting and Best Department of Medical Research, 112 College St, University of Toronto, Toronto, Ontario M5G 1L6, Canada
RNA 10:1813-9. 2004....Gold nanoparticles: a revival in precious metal administration to patients
A S Thakor
Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California 94305 5427, United States
Nano Lett 11:4029-36. 2011..The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed...64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation
Raffaella Rossin
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 46:1210-8. 2005..The purpose of this study was to evaluate 64Cu-radiolabeled folate-conjugated shell cross-linked nanoparticles (SCKs) as candidate agents to shuttle radionuclides and drugs into tumors overexpressing the folate receptor (FR)...Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
Paolo Caliceti
Department of Pharmaceutical Sciences, University of Padua, Via F Marzolo 5, 35131 Padova, Italy
Adv Drug Deliv Rev 55:1261-77. 2003..The examples reported in this review show that general considerations could be useful in developing a target product, although significant deviations from the expected results can not be excluded...Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels
Erik S Mittra
Molecular Imaging Program, Department of Radiology, Division of Nuclear Medicine, Stanford Hospital and Clinics, 300 Pasteur Dr, Room H2200, Stanford, CA 94305 5281, USA
Radiology 260:182-91. 2011....Tissue distribution of quercetin in rats and pigs
Vincent C J de Boer
RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
J Nutr 135:1718-25. 2005..To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0...Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze)
Shao Hua Gu
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Insect Biochem Mol Biol 41:254-63. 2011..The possible physiological functions of these OBPs are discussed...Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
C Andrew Boswell
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Med Chem 47:1465-74. 2004..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...Tissue distribution of porcine peroxisome proliferator-activated receptor alpha: detection of an alternatively spliced mRNA
H Sundvold
Department of Animal Science, Agricultural University of Norway, Box 5025, 1432 Aas, Norway
Gene 273:105-13. 2001..Porcine PPAR alpha was predominantly expressed in kidney and liver in mature individuals. When comparing piglets of a young age, a breed-specific tissue distribution of PPAR alpha mRNA was observed, particularly in liver and heart.Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment
Raymond S H Yang
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan
Environ Health Perspect 115:1339-43. 2007..Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences...The effect of hydrophilic chain length and iRGD on drug delivery from poly(ε-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles
Zhenshu Zhu
Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
Biomaterials 32:9525-35. 2011....Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
Giuseppe Fiermonte
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
J Biol Chem 277:19289-94. 2002....Enhanced antitumor efficacy, biodistribution and penetration of docetaxel-loaded biodegradable nanoparticles
Qin Liu
The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, PR China
Int J Pharm 430:350-8. 2012..Taken together, the reported drug delivery system here could shed light on the future targeted therapy against hepatic carcinoma...Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
Jason P Holland
Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Mol Imaging 10:177-86, 1-3. 2011..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins...Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles
Arnaud Beduneau
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
PLoS ONE 4:e4343. 2009....Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)₂ core shell quantum dots in male Wistar rats
L Ma-Hock
BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany
Toxicol Lett 208:115-24. 2012..There was no evidence that QD were translocated to the central nervous system nor that a systemic acute phase response occurred...Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity
Peihao Yin
Department of Clinical Oncology, Putuo Hospital and Interventional Cancer Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Int J Nanomedicine 7:3961-9. 2012....Effects of cooking and heat treatment on concentration and tissue distribution of okadaic acid and dinophysistoxin-2 in mussels (Mytilus edulis)
Pearse McCarron
Marine Institute, Marine Environment and Food Safety Services, Rinville, Oranmore, Co Galway, Ireland
Toxicon 51:1081-9. 2008..The findings of the studies reported here have importance in terms of the methodology applied in regulatory phycotoxin monitoring programmes. Therefore, options for sample pretreatment are discussed...Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence
William J Ratzan
Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
J Cell Physiol 226:2740-6. 2011....Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel
Li Min Luo
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
Biomaterials 34:1102-14. 2013..NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration...The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models
Wei Zhang
School of Pharmacy, Fudan University, Shanghai, China
Biomaterials 32:5934-44. 2011..In summary, the simple Pluronic-based nanocarrier could be harnessed for the delivery of anticancer drug to melanoma, with increased therapeutic index...Inhalation treatment of pulmonary fibrosis by liposomal prostaglandin E2
Vera Ivanova
Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
Eur J Pharm Biopharm 84:335-44. 2013..The results of the present investigations make the liposomal form of PGE2 an attractive drug for the effective inhalation treatment of idiopathic pulmonary fibrosis...Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
Mingguang Li
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48202, USA
Int J Nanomedicine 7:1345-56. 2012..Further, the predicted biodistribution profiles of PLGA-mPEG495 were close to experimental data, reflecting properly developed property-biodistribution relationships...Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes
Wei Zhao
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
Int J Nanomedicine 6:3087-98. 2011..Caution should be exercised when chemotherapeutic drugs are loaded into CLP for tumor therapy...Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
J F Couse
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 138:4613-21. 1997..of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types...Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
Huan Meng
Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, United States
ACS Nano 5:4131-44. 2011..Further endowment of this multifunctional drug delivery platform with targeting ligands and nanovalves may further enhance cell-specific targeting and on-demand release...Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy
Brandon Kwong
Department of Biological Engineering, Massachusetts Institute of Technology, 77 Mass Ave, Cambridge, MA 02139, USA
Biomaterials 32:5134-47. 2011..The development of a delivery strategy capable of inducing robust anti-tumor responses concurrent with minimal systemic side effects is crucial for the continued progress of potent immunotherapies toward widespread clinical translation...Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles
K Avgoustakis
Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion 26500, Patras, Greece
Int J Pharm 259:115-27. 2003..This may be associated with the effects of the mPEG/PLGA ratio on the density of PEG on the surface of the nanoparticles and on the size of the nanoparticles...Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
Hanwen Zhang
Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
Cancer Res 64:6707-15. 2004....Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme
A L Albiston
Baker Institute of Medical Research, Prahran, Melbourne, Australia
Mol Cell Endocrinol 105:R11-7. 1994..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids...Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion
Haiping Hao
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China
Planta Med 72:1311-7. 2006This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza...Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution
Evin Gultepe
Northeastern University, Boston, MA, USA
Nanomedicine (Lond) 5:1173-82. 2010....Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting
Joost Westerhout
Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
J Pharm Sci 100:3577-93. 2011..g., inhibition of an efflux transporter or induction of pathological state). With the use of advanced mathematical modeling procedures, we may dissect contributions of individual mechanisms in animals as links to the human situation...Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration
Elsa M Janle
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
J Med Food 13:926-33. 2010..To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell ..
Research Grants
- Peptide Derivatives to treat Urinary Tract InfectionsLaszlo Otvos; Fiscal Year: 2003..for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that if appropriately developed, pyrrhocoricin derivatives ..
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..They are evolutionarily highly conserved (found in nematodes and mammals), and some show wide tissue distribution, while others are more selectively expressed by tissue...
- Role for Na,K-ATPase in Nucleoplasmic Calcium HomeostasisCraig Gatto; Fiscal Year: 2010..transport, 2) Identify proteins that retain Na,K-ATPase within the nuclear envelope, and 3) Determine the tissue distribution of nuclear Na,K-ATPase targeting...
- Alzheimer's Disease TherapeuticTrevor P Castor; Fiscal Year: 2012..For selected formulations, radioactive bryostatin 1 will be assayed to determine the pharmacokinetics and tissue distribution. Pharmacologic efficacy will also be measured, particularly in the brain and plasma compartments by total ..
- Lifespan Extension Despite Greatly Elevated Insulin and Body FatDavid E Harrison; Fiscal Year: 2013..The following will be determined: body composition and subcutaneous/visceral fat tissue distribution (using computerized tomography imaging);circulating adipokines (adiponectin, resistin, IL-6, and TNF-alpha);..
- Nanomedicine and NeuroAIDSHoward E Gendelman; Fiscal Year: 2013..synthesized by crystalline particles and evaluated for drug pharmacokinetics (uptake, release, plasma, and tissue distribution)...
- Molecular Mechanisms of Ion Channels in T LymphocytesMichael D Cahalan; Fiscal Year: 2013..Moreover, the human Orai1 and Orai3 proteins differ in their activation requirements and tissue distribution. In this project, we have three goals...
- IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYKARL FRANK AUSTEN; Fiscal Year: 2012..cells;transcriptional regulation of LTC4 synthase and PGD2 synthase;analysis of the lineage progression and tissue distribution of bipotent mast cell/basophil progenitors and their progeny;utilization of strains lacking biosynthesis of ..
- Targeting ATAP-mediated Apoptosis in Treatment of Prostate CancerZelin Sheng; Fiscal Year: 2013..This effort will contain the following two specific aims. Aim 1, test the pharmacokinetic, tissue distribution and toxicological profile of ATAP- iRGD in a mouse model...
- Functions of the Human OST-alpha and OST-beta ProteinsPatricia M Hinkle; Fiscal Year: 2013..Our studies to date of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcriptional regulation, as well as the phenotype of our recently ..
- Using PET isotopes to identify drug targets and to diagnose infectious diseasesPeter J Tonge; Fiscal Year: 2010..In Aim 2 the labeled compounds developed in Aim 1 will be used to image the tissue distribution and metabolic profile of the drugs in healthy control animals using PET...
- Role of TRPM1 (Melastatin1) in the Biology of Human MelanocytesVijayasaradhi Setaluri; Fiscal Year: 2012..Independently, we identified TRPM1 as a gene induced in growth arrested human melanoma cells. Tissue distribution and promoter regulation by microphthalmia transcription factor (MITF) confirmed TRPM1 as a melanocyte-..
- Clinical Study of Disposition and Biological Activity of d-LimoneneH H Sherry Chow; Fiscal Year: 2010..Due to their polarity, the tissue distribution of these metabolites is likely to be limited, thus limiting their in vivo tissue activities...
- Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and SusceptibRichard W Scott; Fiscal Year: 2013..However, while AMPs have good antimicrobial activity, problems with tissue distribution and toxicity have presented obstacles to translating this expensive class of peptides into drugs...
- Developing small molecule therapeutics for lupusThomas R Coleman; Fiscal Year: 2012..2. Characterize the lead and back-up lead in terms of tissue distribution, pharmacokinetics, immunogenicity, as well as residual host immunocompetence, using acute and chronic ..
- Development and testing of polyvalent anthrax toxin inhibitorsJEREMY S MOGRIDGE; Fiscal Year: 2012..The third aim of this proposal is to determine the pharmacokinetics, tissue distribution, mass balance and toxicity of inhibitors...
- Origins of Diversity at Human Classical MHC Class I GenesPETER R PARHAM; Fiscal Year: 2013..and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, and a peptide- binding specificity like HLA-A*02...
- Biomarkers of Kidney PathologySushrut S Waikar; Fiscal Year: 2013..immunohistochemistry will be performed on the most promising biomarkers to identify their tissue distribution and correlation with urinary levels...
- Role for tissue-type plasminogen activator in suppression of hepatic fibrosisLiang I Kang; Fiscal Year: 2013..signaling functions of t-PA in suppressing liver fibrosis, and 3) to determine the changes that occur in tissue distribution of the PAs and their interacting partners between normal and chronically injured liver...
- MR and BL Tracking of Stem/Progenitor Cells in the CNSJeff W Bulte; Fiscal Year: 2013..will use MRI to monitor the accuracy of cell injections, the extent of cell migration and intraparenchymal tissue distribution (white vs...
- Novel small-molecule inhibitors of Wee1 kinase for medulloblastoma treatmentPhilip Reigan; Fiscal Year: 2013..We will then extend our studies into in vivo models to determine the pharmacokinetics and tissue distribution of the Wee1 inhibitors and their effect on tumor growth in our xenograft model.
- Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cellsBRIAN L DIZON; Fiscal Year: 2010..The absolute numbers, phenotype, and tissue distribution of GlcNAc-specific B cells, as well as GlcNAc-specific IgM titers, will be measured by flow cytometry, ..
- Interferon Effects on HIV Transmission in Human ModelsJudy Lieberman; Fiscal Year: 2013..Our first aim is to characterize the cell types, phenotype and tissue distribution of infiltrating hematopoietic cells in normal human cervix and compare it with the distribution of human ..
- Pharmacokinetics and Metabolism of Oxidized CurcuminClaus Schneider; Fiscal Year: 2013..The goal of this grant application is to characterize pharmacokinetics, tissue distribution, and metabolism of the oxidative metabolites of curcumin in the mouse and in human liver microsomes...
- Design and mechanistic studies of mimics of antimicrobial peptidesWilliam F Degrado; Fiscal Year: 2012..they also have significant liabilities including problems associated with their in vivo toxicity and poor tissue distribution, as well as the difficulties and expense of producing these peptides...
- Regulation of renal and bone marrow injury by extracellular vesicle non-coding RNPeter J Quesenberry; Fiscal Year: 2013..Total animal organ histology and survival will also be assessed. Next we will track tissue distribution after an optimal infusion schedule and determine the stability of MSC-dv over time under different ..
- LPL-Deficient Cats-A Quantitative Model of Gene DeliveryPHILIP RICHARD VULLIET; Fiscal Year: 2010..This project will provide important dose-response and time- course data, identify tissue distribution of injected MSCs, and supply other essential cytokinetic data...
- A Topical Host Defense Peptide Mimetic for Oral MucositisRichard W Scott; Fiscal Year: 2012..These small synthetic oligomers are less expensive to produce, have better tissue distribution than HDPs, and are easier to fine-tune structurally to improve activity and minimize toxicity...
- Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in ObesityJerry Ingrande; Fiscal Year: 2013..coronary artery disease, and mortality, and accounts for changes in regional blood flow, adipose tissue distribution, and cardiac function...
- Influence of HFE on metal pharmacokinetics and neurotoxicityJonghan Kim; Fiscal Year: 2013..2) To determine and compare the pharmacokinetics and tissue distribution of 59Fe and 54Mn administered to Hfe-/- and Hfe+/+ "wild-type" control mice by intravenous injection and by ..
- Metabolism of Short Chain Acyl-CoA and its DeficiencyGerard Vockley; Fiscal Year: 2013..They have a more complicated gene structure and more limited tissue distribution than the other ACDs. They also appear to use less abundant, unusual substrates...
- Biological roles of galectinsGERARDO RAUL VASTA; Fiscal Year: 2013..tandem-repeat, and chimeric tandem-repeat galectins, and characterized their developmental expression and tissue distribution. We performed preliminary functional analyses: knockdown embryos for proto type galectins exhibit disrupted ..
- Intracavitary Hemostatic Agent for Non-compressible HemorrhageMartin Bluth; Fiscal Year: 2007..properties of the compound in an intracavitary hemorrhage military-relevant animal model (pig), study tissue distribution, pharmacokinetics, reabsorption and toxicity of HAF...
- Transcriptional Regulation of Development and Maintenance of Memory T LymphocytesH Daniel Lacorazza; Fiscal Year: 2011..of cell cycle inhibitors, limiting the number of memory precursors and therefore modulating the size and tissue distribution of the memory pool over time...
- Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel InhibiJOHN VINCENT MULCAHY; Fiscal Year: 2013..1-1.9 and NaX), each having unique gating properties, and cellular and tissue distribution patterns...
- T Cell Activation in Lymph nodesUlrich H von Andrian; Fiscal Year: 2013..Memory cells are heterogeneous with regard to their function and tissue distribution. The best studied subset are the central memory cells (Tcm), which recirculate through LNs similar to Tn, ..
- Sulfatide-reactive type II NKT cells: repertoire and functionVipin Kumar; Fiscal Year: 2013..in details the TCR V-gene repertoire of type II NKT cells with respect to the antigen fine specificity, tissue distribution and cytokine secretion pattern...
- Copper Transport in LactationMaria Linder; Fiscal Year: 2009..We have obtained evidence that lactation profoundly alters the tissue distribution of newly absorbed Cu, diverting most of it from the liver and kidney to the mammary gland, where it rapidly ..
- Fluorophore-Conjugated Antibodies for Imaging and Resection of GI TumorsMeng Yang; Fiscal Year: 2013..Toxicity, dosing, and tissue distribution studies will be performed for fluorophore-conjugated monoclonal antibodies...
- Body Composition &REE Responses to Bariatric SurgeriesDympna Gallagher; Fiscal Year: 2013..MRI will describe body composition changes at the tissue/organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
- Delivery of Particle Vaccines to Control Trafficking Patterns of T CellsJames Jaehyun Moon; Fiscal Year: 2013..This proposal aims to investigate the relationship between tissue distribution of vaccine particles and trafficking patterns of T cells and to develop a vaccine platform that can exploit ..
- Inducible colon-specific transgenic mouse for cancer researchJames C Fleet; Fiscal Year: 2013..Transgene expression level and tissue distribution will be assessed by PCR...
- Body Composition and the Metabolic Syndrome in Cushing's DiseaseELIZA BREVOORT GEER; Fiscal Year: 2012..abnormal body composition of glucocorticoid excess;and 4) quantify body composition, particularly adipose tissue distribution, by whole-body MRI, with respect to the adipokines leptin and adiponectin...
- Multifunctional nanoparticles for targeting aberrant tumorigenic pathwaysShiladitya Sengupta; Fiscal Year: 2013..At a tissue level, we will test the tissue distribution of the nanoparticles with the anticipation that enhanced delivery to the tumor could be the mechanism ..
- Conditional knockout mice lacking K(ATP) channel subunitsWilliam A Coetzee; Fiscal Year: 2010..Given the rich diversity of KATP channels (both in terms to their tissue distribution and molecular composition), a dire need exists to generate conditional knockout mice devoid of each of the ..
- Optimization of SWCNT/siRNA complex formulation for tumor accumulationLynn Kirkpatrick; Fiscal Year: 2012..a comprehensive examination of a number of formulations of SWCNT/siRNA to determine their tumor and tissue distribution following intravenous administration...
- Elucidating the role of the NPC1L1 cholesterol uptake receptor in HCV infectionSusan L Uprichard; Fiscal Year: 2013..results in binding of the cholesterol-enriched HCV virion and the fact that NPC1L1 exhibits restricted tissue distribution and is expressed on human but not mouse hepatocytes, we hypothesize that NPC1L1 is a cholesterol-dependent ..
- Endosymbiont, Arbovirus &Mosquito Interactions and the Disease ControlZhiyong Xi; Fiscal Year: 2013..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
- Function and pharmacology of schistosome multidrug resistance proteinsRobert M Greenberg; Fiscal Year: 2010..What is the tissue distribution and developmental profile of SMDR2 and other schistosome multi-drug transporters? 3...
- Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening. PhaseKevin M Patrie; Fiscal Year: 2013..The GST classes and their isoforms exhibit marked differences in tissue distribution. For example, GSTA1-1 and A2-2 are the predominant GST enzymes found in the liver, whereas GSTA3-3 is ..
- Neurotropic HIV-1 Reservoirs Inside and Outside the BrainPaul R Clapham; Fiscal Year: 2013..We will use deep sequencing approaches to measure the tissue distribution and prevalence of HIV-1 variants in brain and their relatives outside focusing on brain portals...
- Absorption, Metabolism and Biodistribution of Prions after Oral IngestionClaudio Soto; Fiscal Year: 2013..working hypothesis is that several biological processes, including absorption across intestinal barrier, tissue distribution, metabolism, clearance and peripheral prion replication control the fate of PrPSc in the body and determine ..
- Pharmacokinetics and Pathogenesis of Treatment ResponsesMIGUEL A GOICOECHEA; Fiscal Year: 2010..Membrane transporters have an important role in the absorption, tissue distribution and cellular accumulation of nucleoside analogs...
- Therapeutics of XIAP Degradation by Zinc ChelatorsVladimir M Kolenko; Fiscal Year: 2013..agents in vitro;Aim 2: To examine the oral bioavailability of 5-ALA esterified derivatives and the tissue distribution of 5-ALA induced PPIX in a xenograft model of prostate cancer;Aim 3: To examine the in vivo anti-tumor ..
- Designing Magnetic Resonance Protein-based Contrast Agents with High RelaxivityJenny J Yang; Fiscal Year: 2013..the relaxation theory, our proposed study to improve the relaxivity, targeting capability, and good tumor tissue distribution of the designed contrast agents has potential to overcome the major barriers in the clinical application of ..
- Fate and Effects of Nanoparticles: Relationship to Physicochemical PropertiesALISON CORY PEARSON ELDER; Fiscal Year: 2010..In vivo studies in rats will focus on inflammation and oxidative stress as well as tissue distribution following respiratory tract exposures...
- Molecular regulation of heart valve development and function.Joy Lincoln; Fiscal Year: 2012..In contrast, diseased or malfunctioning valves display drastic alterations in connective tissue distribution. We have shown that mature valve supporting structures express the bHLH transcription factor scleraxis and ..
- Laminins in the SkinMATT PETER MARINKOVICH; Fiscal Year: 2013..a variety of important processes involving cell-matrix interactions and show a remarkable diversity of tissue distribution and function...
- Oxidative Metabolites of Curcumin and their Biological ActivityODAINE GORDON; Fiscal Year: 2013..3) To define the pharmacokinetics and tissue distribution of oxidized curcumin...
- Regulation of Energy Metabolism by PDP1 and PDP2Kirill M Popov; Fiscal Year: 2012..by two closely related phosphatases (PDP1 and PDP2) that are markedly different with respect to their tissue distribution, enzymatic activities and regulation...
- Development of a novel NF-kB antagonist to block cytokine-induced behavioral chanTHADDEUS W PACE; Fiscal Year: 2010..However, curcumin exhibits poor bioavailability due to poor absorption and limited tissue distribution. UBS109 was developed to overcome these limitations, and exhibits greater NF-kB antagonism in combination ..
- MtDNA damage as a biomarker for environmental mitochondrial toxicityJ Timothy Greenamyre; Fiscal Year: 2013..For any given toxin, tissue distribution and pharmacokinetics of the toxin may be unknown...
- Advancing lead dipiperidine compound into preclinical developmentMarina Protopopova; Fiscal Year: 2009..parameters of SQ609 and bioavailability in mice following both IV and PO administration, and the tissue distribution profile of the drug in mice after single dosing...
- Creation and validation of a lux-positive Candida strainYue Fu; Fiscal Year: 2007..However, a crucial limitation of murine models of candidiasis is the need to sacrifice animals to determine tissue distribution of the fungus...
- Phytoestrogens as an alternative treatment for MSLarry Sherman; Fiscal Year: 2006..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
- AZIDE TECHNOLOGY FOR DRUG DEVELOPMENTKyoichi Watanabe; Fiscal Year: 2001..nucleoside can act as a slow releaser of the active antiviral drug with very favorable plasma half-life, tissue distribution and pharmacokinetics...
- Nutritional Biochemistry of beta-Carotene DioxygenaseA Andersson; Fiscal Year: 2005..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
- COMPLEX CARBOHYDRATES OF NERVOUS TISSUERICHARD MARGOLIS; Fiscal Year: 2001....
- FLUORESCENCE-BASED STUDIES OF SPHINGOMYELIN AND CERAMIDEEDWARD SCHUCHMAN; Fiscal Year: 2002..g., uptake, tissue distribution, etc) of the fluorescent enzyme will be monitored in cells and animals...
- DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENTGeorge Painter; Fiscal Year: 2007..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
- ACTIONS OF INSECTICIDES ON SODIUM CHANNEL ISOFORMSDAVID SODERLUND; Fiscal Year: 2000..Sodium channels exist in multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
- CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATIONRICHARD ECKERT; Fiscal Year: 2004..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
- Role of CIC-3 channels in regulation of cell volume and shape in neutrophilsJessica Moreland; Fiscal Year: 2007..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
- MOLECULAR ANALYSIS OF HUMAN SALIVARY CYSTATIN GENESDouglas Dickinson; Fiscal Year: 1991..The multiplicity of type 2 cystatins in humans, their wide tissue distribution, the variation in their relative levels in different sites, and their relative conservation of protein ..
- Development of biomimetic oligomers as anti-coagulant antagonistsRichard Scott; Fiscal Year: 2007..have many advantages over peptides: relatively smaller size which increases stability and enhances tissue distribution, ease of synthesis, resistance to proteolytic degradation, and suitability for medicinal chemistry ..