tissue distribution


Summary: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Top Publications

  1. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
  2. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
  3. pmc Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
  4. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
  5. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
  6. ncbi Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
    Nikolai Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
    Chem Soc Rev 40:1647-71. 2011
  7. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
  8. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
  9. pmc Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
  10. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006

Research Grants

Detail Information

Publications374 found, 100 shown here

  1. ncbi Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    G G Kuiper
    Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
    Endocrinology 138:863-70. 1997
    ..The rat tissue distribution and/or the relative level of ER alpha and ER beta expression seems to be quite different, i.e...
  2. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    ..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
  3. pmc Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
    ..Additionally, we show using HPLC-MS analysis and immunohistochemistry that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS...
  4. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  5. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
  6. ncbi Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
    Nikolai Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
    Chem Soc Rev 40:1647-71. 2011
  7. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  8. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
    ..Nonetheless, the tissue distribution of silver nanopaticles did show a dose-dependent accumulation of silver content in all the tissues examined...
  9. pmc Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
    This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.
  10. ncbi Recent advances in iron oxide nanocrystal technology for medical imaging
    Claire Corot
    Guerbet Research, BP 57400, 95943 Roissy CDG, France
    Adv Drug Deliv Rev 58:1471-504. 2006
    ..Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models...
  11. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  12. ncbi Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
    C Lasagna-Reeves
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Biochem Biophys Res Commun 393:649-55. 2010
    ..The results indicate that tissue accumulation pattern of GNPs depend on the doses administered and the accumulation of the particles does not produce sub-acute physiological damage...
  13. ncbi Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
    Suresh K Balasubramanian
    Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
    Biomaterials 31:2034-42. 2010
    ..These results demonstrate that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs...
  14. pmc Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats
    S Takenaka
    Institute for Inhalation Biology, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    Environ Health Perspect 109:547-51. 2001
  15. ncbi Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    A H Schinkel
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cell 77:491-502. 1994
  16. ncbi Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
    Wan Seob Cho
    Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Appl Pharmacol 236:16-24. 2009
    ..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...
  17. doi In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    Zhuang Liu
    Nat Nanotechnol 2:47-52. 2007
  18. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  19. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
    ..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
  20. ncbi Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
    ..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...
  21. pmc Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
    Parag Aggarwal
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Adv Drug Deliv Rev 61:428-37. 2009
    ..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution...
  22. ncbi The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    Sharmilee Gnanapavan
    Department of Endocrinology, St Bartholomew s and The Royal London Hospital, London ECIA 7BE, UK
    J Clin Endocrinol Metab 87:2988. 2002
    ..GHS-R1b expression was also widespread in all tissues studied. The significance of the widespread tissue distribution of ghrelin remains to be determined...
  23. ncbi Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery
    Giulio F Paciotti
    CytImmune Sciences, Inc, College Park, Maryland 20740, USA
    Drug Deliv 11:169-83. 2004
    ..Finally, PT-cAu-TNF was less toxic and more effective in reducing tumor burden than native TNF since maximal antitumor responses were achieved at lower doses of drug...
  24. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Biol 12:735-9. 2002
    ..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...
  25. ncbi Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase
    Jeong Han Kang
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Eur J Biochem 271:2452-61. 2004
    ..The mRNA master dot-blot for multiple human tissues provided a complete map of the tissue distribution not only for PNPO but also for pyridoxal kinase and pyridoxal phosphatase...
  26. pmc A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development
    Michio Sone
    Department of Cell Biology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Cell Stress Chaperones 18:307-19. 2013
    ..Unexpected glial IRE1/XBP1 activity may provide us with novel insights into the brain homeostasis regulated by the UPR...
  27. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
  28. pmc Rapid translocation of nanoparticles from the lung airspaces to the body
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Biotechnol 28:1300-3. 2010
    ..We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis...
  29. ncbi Biodistribution and toxicity of intravenously administered silica nanoparticles in mice
    Guangping Xie
    Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arch Toxicol 84:183-90. 2010
    ..Here we investigated the long-term (30 days) quantitative tissue distribution, and subcellular distribution, as well as potential toxicity of two sizes of intravenously administered ..
  30. ncbi Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats
    Daniëlle Pk Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Nanomedicine (Lond) 6:339-49. 2011
    ..To develop and determine the safety of gold nanorods, whose aspect ratios can be tuned to obtain plasmon peaks between 650 and 850 nm, as contrast enhancing agents for diagnostic and therapeutic applications...
  31. pmc A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
    F A L M Eskens
    Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Br J Cancer 98:80-5. 2008
    ..No partial or complete responses were observed, stable disease lasting more than four cycles was seen in seven patients. The recommended dose for studies with BIBW 2992 for 14 days followed by 14 days off medication is 70 mg OD...
  32. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
    ..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...
  33. ncbi Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    Nikki Parker
    Endocyte Inc, West Lafayette, IN 47906, USA
    Anal Biochem 338:284-93. 2005
    ..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...
  34. ncbi CSF as a surrogate for assessing CNS exposure: an industrial perspective
    Jiunn H Lin
    Department of Preclinical Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania, USA
    Curr Drug Metab 9:46-59. 2008
    ..Depending on the physicochemical properties of drugs and the site/timing of CSF sampling, the unbound drug concentration at the biophase within the brain could differ significantly from the corresponding CSF drug concentration...
  35. ncbi Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats
    Jun Ho Ji
    Samsung Electronics Co Ltd, Suwon, Korea
    Inhal Toxicol 19:857-71. 2007
  36. ncbi Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
    Margareta Hammarlund-Udenaes
    Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Basic Clin Pharmacol Toxicol 106:215-20. 2010
    ..However, there is an urgent need to collect more relevant data for predicting active site concentrations in tissues with active transporters in their plasma membranes...
  37. ncbi Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
    Ronald J Jandacek
    Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005
    ..Distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra...
  38. ncbi Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study
    Jimena Cazenave
    Universidad Nacional de Cordoba, Facultad de Ciencias Exactas, Fisicas y Naturales, Cátedra Diversidad Animal II, Velez Sarsfield 299, 5000 Cordoba, Argentina
    Aquat Toxicol 75:178-90. 2005
    ..These findings also raise questions on the probable neurotoxicity of microcystins...
  39. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
    ..The results revealed that tissue distribution of gold nanoparticles is size-dependent with the smallest 15 nm nanoparticles showing the most widespread ..
  40. ncbi Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    O Braissant
    Institut de Biologie Animale, , , Switzerland
    Endocrinology 137:354-66. 1996
    ..PPAR-gamma is expressed predominantly in adipose tissue and the immune system. Our results suggest new potential directions to investigate the functions of the different PPAR subtypes...
  41. ncbi Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
    J Mol Endocrinol 35:283-92. 2005
  42. ncbi Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection
    P Laverman
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 298:607-12. 2001
    ..Therefore, these findings may have a considerable impact on the clinical application of liposomal formulations that are administered repeatedly...
  43. ncbi Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats
    Holger Fuchs
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Birkendorfer Str 65, 88397 Biberach Riss, Germany
    Biopharm Drug Dispos 30:229-40. 2009
    ..In order to test these hypotheses, the tissue distribution of BI 1356 was determined in wild-type and DPP-4 deficient rats at different dose levels by means of whole ..
  44. pmc Modulating pharmacokinetics, tumor uptake and biodistribution by engineered nanoparticles
    Rochelle R Arvizo
    Department of Biochemistry and Molecular Biology, Mayo Clinic Rochester, Rochester, Minnesota, United States of America
    PLoS ONE 6:e24374. 2011
  45. ncbi Size and shape effects in the biodistribution of intravascularly injected particles
    P Decuzzi
    Department of Nanomedicine and BioMedical Engineering, The University of Texas Health Science Center, Houston, TX, USA
    J Control Release 141:320-7. 2010
    ..as the diameter d increases, suggesting the use of smaller particles to provide a more uniform tissue distribution. However, discoidal particles have been observed to accumulate more than others in most of the organs but ..
  46. ncbi The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    Minjung Cho
    Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Lett 189:177-83. 2009
    ..and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo...
  47. ncbi Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    Alexandra Aicher
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 107:2134-9. 2003
    ..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals...
  48. ncbi PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
    Yuta Yoshizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Int J Pharm 412:132-41. 2011
    ..These results suggest that PEG liposome would serve as a potent PTX delivery vehicle for the future cancer chemotherapy...
  49. ncbi Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction
    Won Jun Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 47:1295-301. 2006
    ..The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG.
  50. ncbi Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration
    Cheng Feng Luo
    The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510260, China
    Int J Pharm 410:138-44. 2011
    ..The objective of this study was to investigate the pharmacokinetics, tissue distribution and relative bioavailability of puerarin in rats after a single dose intragastric administration of ..
  51. ncbi Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions
    Lei Gao
    Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China
    Int J Pharm 355:321-7. 2008
    The purpose of the present study was to investigate the effects of particle size on the pharmacokinetics and tissue distribution of oridonin nanosuspensions after intravenous administration...
  52. ncbi Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging
    K H Lee
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nucl Med Commun 24:1003-9. 2003
    ..Thus, substrate availability should be considered as a potential limiting factor for photon emission efficiency in certain organs when attempting quantitative interpretation of optical luc gene imaging...
  53. ncbi Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
    M J Egorin
    Division of Developmental Therapeutics, University of Maryland Cancer Center, Baltimore, MD 21201, USA
    Cancer Chemother Pharmacol 47:291-302. 2001
    ..Studies were performed in mice to: (1) define the plasma pharmacokinetics, tissue distribution, and urinary excretion of 17AAG after i.v. delivery; (2) to define the bioavailability of 17AAG after i.p...
  54. ncbi Biomagnification in marine systems: the perspective of an ecologist
    John S Gray
    Department of Biology, University of Oslo, Norway
    Mar Pollut Bull 45:46-52. 2002
    ..Finally suggestions are made as to how data can be collected to better interpret the process of biomagnification in marine food webs...
  55. pmc Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 28:869-76. 2007
    ..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
  56. pmc Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice
    Guodong Zhang
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biomaterials 30:1928-36. 2009
    ..Thus, 20-nm AuNPs coated with TA-terminated PEG(5000) are promising potential drug delivery vehicles and diagnostic imaging agents...
  57. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...
  58. ncbi A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation
    B S Kwon
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 272:14272-6. 1997
    ..A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation...
  59. ncbi Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
    Y Coulouarn
    European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    FEBS Lett 457:28-32. 1999
    ..In situ hybridization histochemistry showed that the prepro-UII gene is predominantly expressed in motoneurons of the brainstem and spinal cord, suggesting that UII may play a role in the control of neuromuscular functions...
  60. pmc P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    A H Schinkel
    The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 97:2517-24. 1996
    ..b>Tissue distribution studies demonstrated that the relative brain penetration of radiolabeled ondansetron and loperamide (and ..
  61. ncbi Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
    Noriyuki Maeda
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    J Control Release 100:41-52. 2004
    ..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...
  62. ncbi A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
    Jasmine P Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int Immunopharmacol 8:401-13. 2008
    ..The model gave satisfactory predictions of CC49 disposition and tumor uptake in man...
  63. ncbi Axon tracts correlate with netrin-1a expression in the zebrafish embryo
    J D Lauderdale
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Mol Cell Neurosci 9:293-313. 1997
    ..These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways...
  64. pmc Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    Henrik Nordman
    Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
    Biochem J 364:191-200. 2002
    ..Following ion-exchange HPLC, both MUC5AC and MUC6 appeared as several distinct populations, probably corresponding to 'glycoforms' of the mucins, the most highly charged of which were found in the gland tissue...
  65. ncbi Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours
    Andreas Helisch
    Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    Eur J Nucl Med Mol Imaging 31:1386-92. 2004
  66. pmc Interferon gamma induction of pulmonary emphysema in the adult murine lung
    Z Wang
    Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    J Exp Med 192:1587-600. 2000
    ..IFN-gamma causes emphysema and alterations in pulmonary protease/antiprotease balance when expressed in pulmonary tissues...
  67. ncbi Anti-inflammatory properties of cerium oxide nanoparticles
    Suzanne M Hirst
    Center for Molecular Medicine and Infectious Diseases CMMID, 1410 Prices Fork Blacksburg, VA 24060, USA
    Small 5:2848-56. 2009
    ..Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation...
  68. pmc Probing microRNAs with microarrays: tissue specificity and functional inference
    Tomas Babak
    Banting and Best Department of Medical Research, 112 College St, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    RNA 10:1813-9. 2004
  69. pmc Gold nanoparticles: a revival in precious metal administration to patients
    A S Thakor
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California 94305 5427, United States
    Nano Lett 11:4029-36. 2011
    ..The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed...
  70. ncbi 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 46:1210-8. 2005
    ..The purpose of this study was to evaluate 64Cu-radiolabeled folate-conjugated shell cross-linked nanoparticles (SCKs) as candidate agents to shuttle radionuclides and drugs into tumors overexpressing the folate receptor (FR)...
  71. ncbi Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
    Paolo Caliceti
    Department of Pharmaceutical Sciences, University of Padua, Via F Marzolo 5, 35131 Padova, Italy
    Adv Drug Deliv Rev 55:1261-77. 2003
    ..The examples reported in this review show that general considerations could be useful in developing a target product, although significant deviations from the expected results can not be excluded...
  72. pmc Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels
    Erik S Mittra
    Molecular Imaging Program, Department of Radiology, Division of Nuclear Medicine, Stanford Hospital and Clinics, 300 Pasteur Dr, Room H2200, Stanford, CA 94305 5281, USA
    Radiology 260:182-91. 2011
  73. ncbi Tissue distribution of quercetin in rats and pigs
    Vincent C J de Boer
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    J Nutr 135:1718-25. 2005
    ..To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0...
  74. ncbi Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze)
    Shao Hua Gu
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Insect Biochem Mol Biol 41:254-63. 2011
    ..The possible physiological functions of these OBPs are discussed...
  75. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  76. ncbi Tissue distribution of porcine peroxisome proliferator-activated receptor alpha: detection of an alternatively spliced mRNA
    H Sundvold
    Department of Animal Science, Agricultural University of Norway, Box 5025, 1432 Aas, Norway
    Gene 273:105-13. 2001
    ..Porcine PPAR alpha was predominantly expressed in kidney and liver in mature individuals. When comparing piglets of a young age, a breed-specific tissue distribution of PPAR alpha mRNA was observed, particularly in liver and heart.
  77. pmc Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment
    Raymond S H Yang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan
    Environ Health Perspect 115:1339-43. 2007
    ..Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences...
  78. ncbi The effect of hydrophilic chain length and iRGD on drug delivery from poly(ε-caprolactone)-poly(N-vinylpyrrolidone) nanoparticles
    Zhenshu Zhu
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Biomaterials 32:9525-35. 2011
  79. ncbi Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
    Giuseppe Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Biol Chem 277:19289-94. 2002
  80. ncbi Enhanced antitumor efficacy, biodistribution and penetration of docetaxel-loaded biodegradable nanoparticles
    Qin Liu
    The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, PR China
    Int J Pharm 430:350-8. 2012
    ..Taken together, the reported drug delivery system here could shed light on the future targeted therapy against hepatic carcinoma...
  81. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011
    ..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins...
  82. pmc Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles
    Arnaud Beduneau
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 4:e4343. 2009
  83. ncbi Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)₂ core shell quantum dots in male Wistar rats
    L Ma-Hock
    BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany
    Toxicol Lett 208:115-24. 2012
    ..There was no evidence that QD were translocated to the central nervous system nor that a systemic acute phase response occurred...
  84. pmc Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity
    Peihao Yin
    Department of Clinical Oncology, Putuo Hospital and Interventional Cancer Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Int J Nanomedicine 7:3961-9. 2012
  85. ncbi Effects of cooking and heat treatment on concentration and tissue distribution of okadaic acid and dinophysistoxin-2 in mussels (Mytilus edulis)
    Pearse McCarron
    Marine Institute, Marine Environment and Food Safety Services, Rinville, Oranmore, Co Galway, Ireland
    Toxicon 51:1081-9. 2008
    ..The findings of the studies reported here have importance in terms of the methodology applied in regulatory phycotoxin monitoring programmes. Therefore, options for sample pretreatment are discussed...
  86. pmc Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence
    William J Ratzan
    Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Cell Physiol 226:2740-6. 2011
  87. ncbi Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel
    Li Min Luo
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
    Biomaterials 34:1102-14. 2013
    ..NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration...
  88. ncbi The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models
    Wei Zhang
    School of Pharmacy, Fudan University, Shanghai, China
    Biomaterials 32:5934-44. 2011
    ..In summary, the simple Pluronic-based nanocarrier could be harnessed for the delivery of anticancer drug to melanoma, with increased therapeutic index...
  89. pmc Inhalation treatment of pulmonary fibrosis by liposomal prostaglandin E2
    Vera Ivanova
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Eur J Pharm Biopharm 84:335-44. 2013
    ..The results of the present investigations make the liposomal form of PGE2 an attractive drug for the effective inhalation treatment of idiopathic pulmonary fibrosis...
  90. pmc Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
    Mingguang Li
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48202, USA
    Int J Nanomedicine 7:1345-56. 2012
    ..Further, the predicted biodistribution profiles of PLGA-mPEG495 were close to experimental data, reflecting properly developed property-biodistribution relationships...
  91. pmc Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes
    Wei Zhao
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Int J Nanomedicine 6:3087-98. 2011
    ..Caution should be exercised when chemotherapeutic drugs are loaded into CLP for tumor therapy...
  92. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
    ..of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types...
  93. pmc Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, United States
    ACS Nano 5:4131-44. 2011
    ..Further endowment of this multifunctional drug delivery platform with targeting ligands and nanovalves may further enhance cell-specific targeting and on-demand release...
  94. pmc Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy
    Brandon Kwong
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Mass Ave, Cambridge, MA 02139, USA
    Biomaterials 32:5134-47. 2011
    ..The development of a delivery strategy capable of inducing robust anti-tumor responses concurrent with minimal systemic side effects is crucial for the continued progress of potent immunotherapies toward widespread clinical translation...
  95. ncbi Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles
    K Avgoustakis
    Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion 26500, Patras, Greece
    Int J Pharm 259:115-27. 2003
    ..This may be associated with the effects of the mPEG/PLGA ratio on the density of PEG on the surface of the nanoparticles and on the size of the nanoparticles...
  96. ncbi Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
    Hanwen Zhang
    Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
    Cancer Res 64:6707-15. 2004
  97. ncbi Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme
    A L Albiston
    Baker Institute of Medical Research, Prahran, Melbourne, Australia
    Mol Cell Endocrinol 105:R11-7. 1994
    ..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids...
  98. ncbi Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion
    Haiping Hao
    Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China
    Planta Med 72:1311-7. 2006
    This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza...
  99. ncbi Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution
    Evin Gultepe
    Northeastern University, Boston, MA, USA
    Nanomedicine (Lond) 5:1173-82. 2010
  100. ncbi Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Pharm Sci 100:3577-93. 2011
    ..g., inhibition of an efflux transporter or induction of pathological state). With the use of advanced mathematical modeling procedures, we may dissect contributions of individual mechanisms in animals as links to the human situation...
  101. pmc Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration
    Elsa M Janle
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
    J Med Food 13:926-33. 2010
    ..To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell ..

Research Grants77

  1. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that if appropriately developed, pyrrhocoricin derivatives ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..They are evolutionarily highly conserved (found in nematodes and mammals), and some show wide tissue distribution, while others are more selectively expressed by tissue...
  4. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    ..transport, 2) Identify proteins that retain Na,K-ATPase within the nuclear envelope, and 3) Determine the tissue distribution of nuclear Na,K-ATPase targeting...
  5. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..For selected formulations, radioactive bryostatin 1 will be assayed to determine the pharmacokinetics and tissue distribution. Pharmacologic efficacy will also be measured, particularly in the brain and plasma compartments by total ..
  6. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..The following will be determined: body composition and subcutaneous/visceral fat tissue distribution (using computerized tomography imaging);circulating adipokines (adiponectin, resistin, IL-6, and TNF-alpha);..
  7. Nanomedicine and NeuroAIDS
    Howard E Gendelman; Fiscal Year: 2013
    ..synthesized by crystalline particles and evaluated for drug pharmacokinetics (uptake, release, plasma, and tissue distribution)...
  8. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Moreover, the human Orai1 and Orai3 proteins differ in their activation requirements and tissue distribution. In this project, we have three goals...
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..cells;transcriptional regulation of LTC4 synthase and PGD2 synthase;analysis of the lineage progression and tissue distribution of bipotent mast cell/basophil progenitors and their progeny;utilization of strains lacking biosynthesis of ..
  10. Targeting ATAP-mediated Apoptosis in Treatment of Prostate Cancer
    Zelin Sheng; Fiscal Year: 2013
    ..This effort will contain the following two specific aims. Aim 1, test the pharmacokinetic, tissue distribution and toxicological profile of ATAP- iRGD in a mouse model...
  11. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..Our studies to date of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcriptional regulation, as well as the phenotype of our recently ..
  12. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..In Aim 2 the labeled compounds developed in Aim 1 will be used to image the tissue distribution and metabolic profile of the drugs in healthy control animals using PET...
  13. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..Independently, we identified TRPM1 as a gene induced in growth arrested human melanoma cells. Tissue distribution and promoter regulation by microphthalmia transcription factor (MITF) confirmed TRPM1 as a melanocyte-..
  14. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..Due to their polarity, the tissue distribution of these metabolites is likely to be limited, thus limiting their in vivo tissue activities...
  15. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2013
    ..However, while AMPs have good antimicrobial activity, problems with tissue distribution and toxicity have presented obstacles to translating this expensive class of peptides into drugs...
  16. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    ..2. Characterize the lead and back-up lead in terms of tissue distribution, pharmacokinetics, immunogenicity, as well as residual host immunocompetence, using acute and chronic ..
  17. Development and testing of polyvalent anthrax toxin inhibitors
    JEREMY S MOGRIDGE; Fiscal Year: 2012
    ..The third aim of this proposal is to determine the pharmacokinetics, tissue distribution, mass balance and toxicity of inhibitors...
  18. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, and a peptide- binding specificity like HLA-A*02...
  19. Biomarkers of Kidney Pathology
    Sushrut S Waikar; Fiscal Year: 2013
    ..immunohistochemistry will be performed on the most promising biomarkers to identify their tissue distribution and correlation with urinary levels...
  20. Role for tissue-type plasminogen activator in suppression of hepatic fibrosis
    Liang I Kang; Fiscal Year: 2013
    ..signaling functions of t-PA in suppressing liver fibrosis, and 3) to determine the changes that occur in tissue distribution of the PAs and their interacting partners between normal and chronically injured liver...
  21. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2013
    ..will use MRI to monitor the accuracy of cell injections, the extent of cell migration and intraparenchymal tissue distribution (white vs...
  22. Novel small-molecule inhibitors of Wee1 kinase for medulloblastoma treatment
    Philip Reigan; Fiscal Year: 2013
    ..We will then extend our studies into in vivo models to determine the pharmacokinetics and tissue distribution of the Wee1 inhibitors and their effect on tumor growth in our xenograft model.
  23. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..The absolute numbers, phenotype, and tissue distribution of GlcNAc-specific B cells, as well as GlcNAc-specific IgM titers, will be measured by flow cytometry, ..
  24. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2013
    ..Our first aim is to characterize the cell types, phenotype and tissue distribution of infiltrating hematopoietic cells in normal human cervix and compare it with the distribution of human ..
  25. Pharmacokinetics and Metabolism of Oxidized Curcumin
    Claus Schneider; Fiscal Year: 2013
    ..The goal of this grant application is to characterize pharmacokinetics, tissue distribution, and metabolism of the oxidative metabolites of curcumin in the mouse and in human liver microsomes...
  26. Design and mechanistic studies of mimics of antimicrobial peptides
    William F Degrado; Fiscal Year: 2012
    ..they also have significant liabilities including problems associated with their in vivo toxicity and poor tissue distribution, as well as the difficulties and expense of producing these peptides...
  27. Regulation of renal and bone marrow injury by extracellular vesicle non-coding RN
    Peter J Quesenberry; Fiscal Year: 2013
    ..Total animal organ histology and survival will also be assessed. Next we will track tissue distribution after an optimal infusion schedule and determine the stability of MSC-dv over time under different ..
  28. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..This project will provide important dose-response and time- course data, identify tissue distribution of injected MSCs, and supply other essential cytokinetic data...
  29. A Topical Host Defense Peptide Mimetic for Oral Mucositis
    Richard W Scott; Fiscal Year: 2012
    ..These small synthetic oligomers are less expensive to produce, have better tissue distribution than HDPs, and are easier to fine-tune structurally to improve activity and minimize toxicity...
  30. Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
    Jerry Ingrande; Fiscal Year: 2013
    ..coronary artery disease, and mortality, and accounts for changes in regional blood flow, adipose tissue distribution, and cardiac function...
  31. Influence of HFE on metal pharmacokinetics and neurotoxicity
    Jonghan Kim; Fiscal Year: 2013
    ..2) To determine and compare the pharmacokinetics and tissue distribution of 59Fe and 54Mn administered to Hfe-/- and Hfe+/+ "wild-type" control mice by intravenous injection and by ..
  32. Metabolism of Short Chain Acyl-CoA and its Deficiency
    Gerard Vockley; Fiscal Year: 2013
    ..They have a more complicated gene structure and more limited tissue distribution than the other ACDs. They also appear to use less abundant, unusual substrates...
  33. Biological roles of galectins
    GERARDO RAUL VASTA; Fiscal Year: 2013
    ..tandem-repeat, and chimeric tandem-repeat galectins, and characterized their developmental expression and tissue distribution. We performed preliminary functional analyses: knockdown embryos for proto type galectins exhibit disrupted ..
  34. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..properties of the compound in an intracavitary hemorrhage military-relevant animal model (pig), study tissue distribution, pharmacokinetics, reabsorption and toxicity of HAF...
  35. Transcriptional Regulation of Development and Maintenance of Memory T Lymphocytes
    H Daniel Lacorazza; Fiscal Year: 2011
    ..of cell cycle inhibitors, limiting the number of memory precursors and therefore modulating the size and tissue distribution of the memory pool over time...
  36. Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel Inhibi
    JOHN VINCENT MULCAHY; Fiscal Year: 2013
    ..1-1.9 and NaX), each having unique gating properties, and cellular and tissue distribution patterns...
  37. T Cell Activation in Lymph nodes
    Ulrich H von Andrian; Fiscal Year: 2013
    ..Memory cells are heterogeneous with regard to their function and tissue distribution. The best studied subset are the central memory cells (Tcm), which recirculate through LNs similar to Tn, ..
  38. Sulfatide-reactive type II NKT cells: repertoire and function
    Vipin Kumar; Fiscal Year: 2013
    ..in details the TCR V-gene repertoire of type II NKT cells with respect to the antigen fine specificity, tissue distribution and cytokine secretion pattern...
  39. Copper Transport in Lactation
    Maria Linder; Fiscal Year: 2009
    ..We have obtained evidence that lactation profoundly alters the tissue distribution of newly absorbed Cu, diverting most of it from the liver and kidney to the mammary gland, where it rapidly ..
  40. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2013
    ..Toxicity, dosing, and tissue distribution studies will be performed for fluorophore-conjugated monoclonal antibodies...
  41. Body Composition &REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2013
    ..MRI will describe body composition changes at the tissue/organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
  42. Delivery of Particle Vaccines to Control Trafficking Patterns of T Cells
    James Jaehyun Moon; Fiscal Year: 2013
    ..This proposal aims to investigate the relationship between tissue distribution of vaccine particles and trafficking patterns of T cells and to develop a vaccine platform that can exploit ..
  43. Inducible colon-specific transgenic mouse for cancer research
    James C Fleet; Fiscal Year: 2013
    ..Transgene expression level and tissue distribution will be assessed by PCR...
  44. Body Composition and the Metabolic Syndrome in Cushing's Disease
    ELIZA BREVOORT GEER; Fiscal Year: 2012
    ..abnormal body composition of glucocorticoid excess;and 4) quantify body composition, particularly adipose tissue distribution, by whole-body MRI, with respect to the adipokines leptin and adiponectin...
  45. Multifunctional nanoparticles for targeting aberrant tumorigenic pathways
    Shiladitya Sengupta; Fiscal Year: 2013
    ..At a tissue level, we will test the tissue distribution of the nanoparticles with the anticipation that enhanced delivery to the tumor could be the mechanism ..
  46. Conditional knockout mice lacking K(ATP) channel subunits
    William A Coetzee; Fiscal Year: 2010
    ..Given the rich diversity of KATP channels (both in terms to their tissue distribution and molecular composition), a dire need exists to generate conditional knockout mice devoid of each of the ..
  47. Optimization of SWCNT/siRNA complex formulation for tumor accumulation
    Lynn Kirkpatrick; Fiscal Year: 2012
    ..a comprehensive examination of a number of formulations of SWCNT/siRNA to determine their tumor and tissue distribution following intravenous administration...
  48. Elucidating the role of the NPC1L1 cholesterol uptake receptor in HCV infection
    Susan L Uprichard; Fiscal Year: 2013
    ..results in binding of the cholesterol-enriched HCV virion and the fact that NPC1L1 exhibits restricted tissue distribution and is expressed on human but not mouse hepatocytes, we hypothesize that NPC1L1 is a cholesterol-dependent ..
  49. Endosymbiont, Arbovirus &Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2013
    ..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
  50. Function and pharmacology of schistosome multidrug resistance proteins
    Robert M Greenberg; Fiscal Year: 2010
    ..What is the tissue distribution and developmental profile of SMDR2 and other schistosome multi-drug transporters? 3...
  51. Advanced GST Proteomics for Early Stage Organ-Specific Toxicity Screening. Phase
    Kevin M Patrie; Fiscal Year: 2013
    ..The GST classes and their isoforms exhibit marked differences in tissue distribution. For example, GSTA1-1 and A2-2 are the predominant GST enzymes found in the liver, whereas GSTA3-3 is ..
  52. Neurotropic HIV-1 Reservoirs Inside and Outside the Brain
    Paul R Clapham; Fiscal Year: 2013
    ..We will use deep sequencing approaches to measure the tissue distribution and prevalence of HIV-1 variants in brain and their relatives outside focusing on brain portals...
  53. Absorption, Metabolism and Biodistribution of Prions after Oral Ingestion
    Claudio Soto; Fiscal Year: 2013
    ..working hypothesis is that several biological processes, including absorption across intestinal barrier, tissue distribution, metabolism, clearance and peripheral prion replication control the fate of PrPSc in the body and determine ..
  54. Pharmacokinetics and Pathogenesis of Treatment Responses
    MIGUEL A GOICOECHEA; Fiscal Year: 2010
    ..Membrane transporters have an important role in the absorption, tissue distribution and cellular accumulation of nucleoside analogs...
  55. Therapeutics of XIAP Degradation by Zinc Chelators
    Vladimir M Kolenko; Fiscal Year: 2013
    ..agents in vitro;Aim 2: To examine the oral bioavailability of 5-ALA esterified derivatives and the tissue distribution of 5-ALA induced PPIX in a xenograft model of prostate cancer;Aim 3: To examine the in vivo anti-tumor ..
  56. Designing Magnetic Resonance Protein-based Contrast Agents with High Relaxivity
    Jenny J Yang; Fiscal Year: 2013
    ..the relaxation theory, our proposed study to improve the relaxivity, targeting capability, and good tumor tissue distribution of the designed contrast agents has potential to overcome the major barriers in the clinical application of ..
  57. Fate and Effects of Nanoparticles: Relationship to Physicochemical Properties
    ALISON CORY PEARSON ELDER; Fiscal Year: 2010
    ..In vivo studies in rats will focus on inflammation and oxidative stress as well as tissue distribution following respiratory tract exposures...
  58. Molecular regulation of heart valve development and function.
    Joy Lincoln; Fiscal Year: 2012
    ..In contrast, diseased or malfunctioning valves display drastic alterations in connective tissue distribution. We have shown that mature valve supporting structures express the bHLH transcription factor scleraxis and ..
  59. Laminins in the Skin
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..a variety of important processes involving cell-matrix interactions and show a remarkable diversity of tissue distribution and function...
  60. Oxidative Metabolites of Curcumin and their Biological Activity
    ODAINE GORDON; Fiscal Year: 2013
    ..3) To define the pharmacokinetics and tissue distribution of oxidized curcumin...
  61. Regulation of Energy Metabolism by PDP1 and PDP2
    Kirill M Popov; Fiscal Year: 2012
    ..by two closely related phosphatases (PDP1 and PDP2) that are markedly different with respect to their tissue distribution, enzymatic activities and regulation...
  62. Development of a novel NF-kB antagonist to block cytokine-induced behavioral chan
    THADDEUS W PACE; Fiscal Year: 2010
    ..However, curcumin exhibits poor bioavailability due to poor absorption and limited tissue distribution. UBS109 was developed to overcome these limitations, and exhibits greater NF-kB antagonism in combination ..
  63. MtDNA damage as a biomarker for environmental mitochondrial toxicity
    J Timothy Greenamyre; Fiscal Year: 2013
    ..For any given toxin, tissue distribution and pharmacokinetics of the toxin may be unknown...
  64. Advancing lead dipiperidine compound into preclinical development
    Marina Protopopova; Fiscal Year: 2009
    ..parameters of SQ609 and bioavailability in mice following both IV and PO administration, and the tissue distribution profile of the drug in mice after single dosing...
  65. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    ..However, a crucial limitation of murine models of candidiasis is the need to sacrifice animals to determine tissue distribution of the fungus...
  66. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  67. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
    Kyoichi Watanabe; Fiscal Year: 2001
    ..nucleoside can act as a slow releaser of the active antiviral drug with very favorable plasma half-life, tissue distribution and pharmacokinetics...
  69. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005
    ..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
    RICHARD MARGOLIS; Fiscal Year: 2001
    EDWARD SCHUCHMAN; Fiscal Year: 2002
    ..g., uptake, tissue distribution, etc) of the fluorescent enzyme will be monitored in cells and animals...
    George Painter; Fiscal Year: 2007
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
    DAVID SODERLUND; Fiscal Year: 2000
    ..Sodium channels exist in multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
    RICHARD ECKERT; Fiscal Year: 2004
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  75. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
    Douglas Dickinson; Fiscal Year: 1991
    ..The multiplicity of type 2 cystatins in humans, their wide tissue distribution, the variation in their relative levels in different sites, and their relative conservation of protein ..
  77. Development of biomimetic oligomers as anti-coagulant antagonists
    Richard Scott; Fiscal Year: 2007
    ..have many advantages over peptides: relatively smaller size which increases stability and enhances tissue distribution, ease of synthesis, resistance to proteolytic degradation, and suitability for medicinal chemistry ..