tissue distribution

Summary

Summary: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Top Publications

  1. ncbi Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
  2. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
  3. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  4. ncbi In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    Zhuang Liu
    Nat Nanotechnol 2:47-52. 2007
  5. ncbi Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
  6. ncbi Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
  7. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
  8. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Curr Biol 12:735-9. 2002
  9. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
  10. ncbi Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study
    Jimena Cazenave
    , Facultad de Ciencias Exactas, , , Velez Sarsfield 299, , Argentina
    Aquat Toxicol 75:178-90. 2005

Research Grants

  1. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
  2. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2010
  3. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
  4. PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORS
    Joel Linden; Fiscal Year: 1993
  5. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
  6. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
  7. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2010
  8. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
  9. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
  10. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005

Detail Information

Publications298 found, 100 shown here

  1. ncbi Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
    This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.
  2. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    ..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
  3. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  4. ncbi In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    Zhuang Liu
    Nat Nanotechnol 2:47-52. 2007
  5. ncbi Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
    ..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...
  6. ncbi Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
    ..Additionally, we show using HPLC-MS analysis and immunohistochemistry that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS...
  7. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...
  8. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Curr Biol 12:735-9. 2002
    ..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...
  9. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
    ..The results revealed that tissue distribution of gold nanoparticles is size-dependent with the smallest 15 nm nanoparticles showing the most widespread ..
  10. ncbi Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study
    Jimena Cazenave
    , Facultad de Ciencias Exactas, , , Velez Sarsfield 299, , Argentina
    Aquat Toxicol 75:178-90. 2005
    ..These findings also raise questions on the probable neurotoxicity of microcystins...
  11. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  12. ncbi The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    Sharmilee Gnanapavan
    Department of Endocrinology, St Bartholomew s and The Royal London Hospital, London ECIA 7BE, UK
    J Clin Endocrinol Metab 87:2988. 2002
    ..GHS-R1b expression was also widespread in all tissues studied. The significance of the widespread tissue distribution of ghrelin remains to be determined...
  13. ncbi Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions
    Lei Gao
    Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China
    Int J Pharm 355:321-7. 2008
    The purpose of the present study was to investigate the effects of particle size on the pharmacokinetics and tissue distribution of oridonin nanosuspensions after intravenous administration...
  14. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  15. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  16. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
  17. ncbi Axon tracts correlate with netrin-1a expression in the zebrafish embryo
    J D Lauderdale
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Mol Cell Neurosci 9:293-313. 1997
    ..These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways...
  18. ncbi Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    Alexandra Aicher
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 107:2134-9. 2003
    ..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals...
  19. ncbi Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours
    Andreas Helisch
    Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    Eur J Nucl Med Mol Imaging 31:1386-92. 2004
    ....
  20. ncbi Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction
    Won Jun Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 47:1295-301. 2006
    ..The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG...
  21. ncbi Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    Henrik Nordman
    Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
    Biochem J 364:191-200. 2002
    ..Following ion-exchange HPLC, both MUC5AC and MUC6 appeared as several distinct populations, probably corresponding to 'glycoforms' of the mucins, the most highly charged of which were found in the gland tissue...
  22. ncbi Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
    Noriyuki Maeda
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52-1 Yada, Shizuoka 422-8526, Japan
    J Control Release 100:41-52. 2004
    ..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...
  23. ncbi A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
    Jasmine P Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int Immunopharmacol 8:401-13. 2008
    ..The model gave satisfactory predictions of CC49 disposition and tumor uptake in man...
  24. ncbi The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    Minjung Cho
    Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Lett 189:177-83. 2009
    ..and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo...
  25. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
    ..AVAILABILITY: All data and analyses are publically available at the GeneNote website, http://genecards.weizmann.ac.il/genenote/ and, GEO accession GSE803. CONTACT: SUPPLEMENTARY INFORMATION: Four tables available at the above site...
  26. ncbi Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    Angie L Bookout
    Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, 75390, USA
    Cell 126:789-99. 2006
    ..These data reveal a hierarchical transcriptional circuitry that extends beyond individual tissues to form a meganetwork governing physiology on an organismal scale...
  27. ncbi Evaluation of iron oxide nanoparticle biocompatibility
    Amel Hanini
    Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
    Int J Nanomedicine 6:787-94. 2011
    ..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
  28. ncbi In vivo PET imaging and biodistribution of radiolabeled gold nanoshells in rats with tumor xenografts
    Huan Xie
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburn St, Houston, TX 77004, United States
    Int J Pharm 395:324-30. 2010
    ..Overall, PET images with (64)Cu had good resolution and therefore can be further applied to guide photothermal treatment of cancer...
  29. ncbi Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    A H Schinkel
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cell 77:491-502. 1994
    ....
  30. ncbi Whole-body physiologically based pharmacokinetic models
    Ivan Nestorov
    ZymoGenetics Inc, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
    Expert Opin Drug Metab Toxicol 3:235-49. 2007
    ....
  31. ncbi A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeleton
    Nancy Braverman
    Department of Human Genetics and Pediatrics, Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada
    Mol Genet Metab 99:408-16. 2010
    ..The role of plasmalogens in the normal function of these tissues at various ages can now be studied and additional therapeutic interventions tested in this model...
  32. ncbi Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
    Amit Garg
    Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:687-709. 2007
    ..functions to protect immune gamma globulin (IgG) from elimination, the influence of FcRn on the tissue distribution of IgG has not been quantified...
  33. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
    ..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
  34. ncbi Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers
    A F Ruchon
    Departement de Biochimie, Universite de Montreal, Canada
    J Bone Miner Res 15:1440-50. 2000
    ..We characterized the developmental expression and tissue distribution of Phex protein, using a monoclonal antibody against human PHEX, examined the effect of the Hyp mutation on ..
  35. ncbi High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Cancer Res 59:2635-43. 1999
    ..Due to its short physical half-life, 213Bi appears to be especially suitable for use in conjunction with fast-clearing fragments...
  36. ncbi Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection
    P Laverman
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 298:607-12. 2001
    ..Therefore, these findings may have a considerable impact on the clinical application of liposomal formulations that are administered repeatedly...
  37. ncbi Inhibition of cancer growth by resveratrol is related to its low bioavailability
    Miguel Asensi
    , Universidad de Valencia, Valencia, Spain
    Free Radic Biol Med 33:387-98. 2002
    ....
  38. ncbi Cell-type-specific signatures of microRNAs on target mRNA expression
    Pranidhi Sood
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 103:2746-51. 2006
    ..We show that this tool can identify functionally important 3' UTR motifs without cross-species comparison...
  39. ncbi In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer
    Emilia S Olson
    Department of Pharmacology, La Jolla, CA 92093 0647, USA
    Integr Biol (Camb) 1:382-93. 2009
    ..Our results validate an approach that should generally deliver imaging agents and chemotherapeutics to sites of invasion, tumor-promoting inflammation, and metastasis...
  40. ncbi Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge
    Y Yamamoto
    Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
    J Control Release 77:27-38. 2001
    ....
  41. ncbi Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
    Hanwen Zhang
    Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
    Cancer Res 64:6707-15. 2004
    ....
  42. ncbi A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans
    G Carrier
    Chair in Toxicological Risk Assessment for Human Health, Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, Main Station, Montreal, Quebec, H3C 3J7, Canada
    Toxicol Appl Pharmacol 171:50-60. 2001
    ..Thus, accessible measurements on these matrices allow inferences of past, present, and future burdens. This could prove to be a useful tool in assessing the health risks associated with various circumstances of methyl mercury exposure...
  43. ncbi Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons
    Marjo Piltonen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
    Exp Neurol 219:499-506. 2009
    ..The results imply that GDNF binding to HSs is needed for the optimum neuroprotective effect...
  44. ncbi Cloning and functional expression of a human liver organic cation transporter
    L Zhang
    Department of Biopharmaceutical Sciences, University of California San Francisco 94143, USA
    Mol Pharmacol 51:913-21. 1997
    ..In comparison to rOCT1, hOCT1 exhibits notable differences in its kinetic characteristics and tissue distribution. The functional expression of hOCT1 will provide a powerful tool for elucidation of the mechanisms of ..
  45. ncbi Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice
    J Dowling
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, Chicago, Illinois 60637, USA
    Dev Biol 187:131-42. 1997
    ..Collectively, our findings suggest a mechanism for the BPAG1 null phenotype and indicate that different neurons respond differently to the absence of BPAG1-n, a cytoskeletal linker protein...
  46. ncbi Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives
    Martin Behe
    Department of Nuclear Medicine, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Eur J Nucl Med Mol Imaging 30:1140-6. 2003
    ..DTPA- dGlu(1)-minigastrin is preferred to "monofunctional" DTPA-Leu(1)-minigastrin for diagnostic application with (111)In for the in vivo detection of CCK-B receptor-expressing tissues...
  47. ncbi Modelling and PBPK simulation in drug discovery
    Hannah M Jones
    Pfizer Global R and D, Department of Pharmacokinetics, Dynamics and Metabolism, IPC 654, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
    AAPS J 11:155-66. 2009
    ....
  48. ncbi Antisense therapeutics
    S Agrawal
    Hybridon Inc, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 2:519-28. 1998
    ..Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously...
  49. ncbi Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14 C-bortezomib
    Alex Hemeryck
    Global Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, A Division of Janssen Pharmaceutica N V, Beerse, Belgium
    Cancer Chemother Pharmacol 60:777-87. 2007
    ..The body distribution of total radioactivity (TR) and bortezomib was investigated in male Sprague-Dawley rats after single and repeated i.v. (bolus) administration with (14)C-labelled bortezomib (VELCADE) (0.2 mg/kg; 0.28 MBq./kg)...
  50. ncbi PET of EGFR antibody distribution in head and neck squamous cell carcinoma models
    Gang Niu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 50:1116-23. 2009
    ....
  51. ncbi Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity
    Wei Wu
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People s Republic of China
    ACS Nano 3:2740-50. 2009
    ....
  52. ncbi Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging
    K-H Lee
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nucl Med Commun 24:1003-9. 2003
    ..Thus, substrate availability should be considered as a potential limiting factor for photon emission efficiency in certain organs when attempting quantitative interpretation of optical luc gene imaging...
  53. ncbi Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
    Cancer Res 67:718-26. 2007
    ..Finally, the 125I/111In biodistribution data allowed for dose estimations, which suggest the 131I-labeled scFv-Fc H310A/H435Q as a promising candidate for radioimmunotherapy...
  54. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002
    ..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
  55. ncbi Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs
    Theodosia Maina
    Institute of Radioisotopes Radiodiagnostic Products, National Center for Scientific Research Demokritos, 152 10 Ag Paraskevi Arrikis, Athens, Greece
    J Nucl Med 46:823-30. 2005
    ....
  56. ncbi Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues
    T A Cook
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905
    Proc Natl Acad Sci U S A 91:644-8. 1994
    ....
  57. ncbi Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions
    Arnaud Menuet
    Endocrinologie Moleculaire de la Reproduction, UMR CNRS 6026, Campus de Beaulieu, 35042 Rennes Cedex, France
    Biol Reprod 66:1881-92. 2002
    ..b>Tissue distribution pattern, analyzed by reverse transcription polymerase chain reaction, showed that the three zfER mRNAs ..
  58. ncbi Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice
    H Fu
    Center for Gene Therapy, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Gene Ther 14:1065-77. 2007
    ..This study demonstrated the great potential of combining i.v. and i.c. administration for improving rAAV CNS gene delivery and developing rAAV gene therapy for treating MPS IIIB in patients...
  59. ncbi The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter
    G Zsurka
    Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr Bohrgasse 9, Vienna, A 1030, Austria
    Genomics 72:158-68. 2001
    ..Like its yeast homologues, hsaMrs2p has been localized in mitochondria. The hsaMRS2 gene is located on chromosome 6 (6p22.1-p22.3) and is composed of 11 exons. A low level of the transcript is detected in various mouse tissues...
  60. ncbi Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme
    A L Albiston
    Baker Institute of Medical Research, Prahran, Melbourne, Australia
    Mol Cell Endocrinol 105:R11-7. 1994
    ..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids...
  61. ncbi Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans
    S N Gettner
    Department of Physiology, University of California, San Francisco 94143, USA
    J Cell Biol 129:1127-41. 1995
    ....
  62. ncbi Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice
    Guodong Zhang
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Biomaterials 30:1928-36. 2009
    ..Thus, 20-nm AuNPs coated with TA-terminated PEG(5000) are promising potential drug delivery vehicles and diagnostic imaging agents...
  63. ncbi Death-from-cancer signatures and stem cell contribution to metastatic cancer
    Gennadi V Glinsky
    Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Division of Urology, Albany Medical College, Albany, New York 12208, USA
    Cell Cycle 4:1171-5. 2005
    ....
  64. ncbi Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor-bearing mice
    M S Newman
    SEQUUS Pharmaceuticals, Inc, Menlo Park, CA 94025, USA
    Cancer Chemother Pharmacol 43:1-7. 1999
    ....
  65. ncbi In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3
    Weibo Cai
    The Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305-5484, USA
    Cancer Res 66:9673-81. 2006
    ..Chemotherapeutics or radiotherapeutics using Abegrin as the delivering vehicle may also be effective in treating integrin alpha(v)beta(3)-positive tumors...
  66. ncbi Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
    Nobuhiro Nishiyama
    Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Pharmacol Ther 112:630-48. 2006
    ..Thus, polymeric micelles are nanotechnology-based carrier systems that might exert the activity of potent bioactive compounds in a site-directed manner, ensuring their effectiveness and safety in the clinical use...
  67. ncbi Developmental and tissue expression patterns of histone macroH2A1 subtypes
    J R Pehrson
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104 6048, USA
    J Cell Biochem 65:107-13. 1997
    ..These results support the idea that macroH2A1.1 and macroH2A1.2 are functionally distinct, and suggest that changes in their expression may play a role in developmentally regulated changes in chromatin structure and function...
  68. ncbi Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders
    Robert McGlynn
    Sidney Weisner Laboratory of Genetic Neurological Disease, Department of Neuroscience, Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Comp Neurol 480:415-26. 2004
    ....
  69. ncbi Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water
    E M Kenyon
    Experimental Toxicology Division, Mail Stop B143 01, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 232:448-55. 2008
    ..In this study, dose-dependency in tissue distribution and urinary excretion for inorganic arsenic and its methylated metabolites was assessed in female C57Bl/6 ..
  70. ncbi Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
    De Sheng Wang
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkuo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 302:510-5. 2002
    ..To investigate the role of Oct1 in the disposition of metformin, the tissue distribution of metformin was determined in Oct1 gene-knockout mice after i.v. administration...
  71. ncbi Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin
    Laura Borsi
    Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Cancer 102:75-85. 2002
    ..Furthermore, the fact that ED-B is 100% homologous in human and mouse, which ensures that L19 reacts equally well with the human and the murine antigen, should expedite the transfer of these reagents to clinical trials...
  72. ncbi An overview of the MAGE gene family with the identification of all human members of the family
    P Chomez
    Ludwig Institute for Cancer Research, Brussels Branch, and Cellular Genetics Unit, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cancer Res 61:5544-51. 2001
    ..Intriguingly, the COOH-terminal domain of MAGE-D3 was found to be identical to trophinin, a previously described protein believed to be involved in embryo implantation...
  73. ncbi Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT)
    Sylvie Kossodo
    VisEn Medical, Bedford, MA, USA
    Mol Imaging Biol 12:488-99. 2010
    ..We developed a novel near-infrared-labeled optical agent for the in vivo detection and quantification of α(v)β(3)/α(v)β(5)...
  74. ncbi PK and tissue distribution of docetaxel in rabbits after i.v. administration of liposomal and injectable formulations
    Ling Zhao
    Research Laboratory of Medicinal chemistry and Biomaterials, Chongqing Pharmaceutical Engineering Research Center, School of Pharmacy, Chongqing Medical University, Chongqing, PR China
    J Pharm Biomed Anal 49:989-96. 2009
    ..The analysis method was successfully applied to pharmacokinetics and tissue distribution studies of DTX liposomes and DTX injection after i.v. administration to the rabbits...
  75. ncbi The biopersistence of Canadian chrysotile asbestos following inhalation: final results through 1 year after cessation of exposure
    David Bernstein
    Consultant in Toxicology, Geneva, Switzerland
    Inhal Toxicol 17:1-14. 2005
    ..1998). These results fully support the differentiation of chrysotile from amphiboles reported in recent evaluations of available epidemiological studies (Hodgson & Darnton, 2000; Berman & Crump, 2004)...
  76. ncbi Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic/pharmacodynamic indices
    April Barbour
    GlaxoSmithKline, King of Prussia, PA, USA
    Int J Antimicrob Agents 35:431-8. 2010
    ..the mechanism of action, the microbial kill kinetics, the degree of protein binding and the degree of tissue distribution. Studies have traditionally emphasised the first two factors, whilst the significance of protein binding ..
  77. ncbi Cloning and expression of three aquaporin homologues from the European eel (Anguilla anguilla): effects of seawater acclimation and cortisol treatment on renal expression
    Anne-Sophie Martinez
    School of Biology, Bute Medical Buildings, University of St. Andrews, St. Andrews, Fife, Scotland, KY16 9TS, UK
    Biol Cell 97:615-27. 2005
    ..Northern-blot analysis revealed (i) two AQP1 transcripts exhibiting a wide tissue distribution, (ii) a single AQP1dup mRNA transcript found in the kidney and the oesophagus, and (iii) a single AQPe mRNA ..
  78. ncbi Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels
    Tomohiro Asai
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan
    FEBS Lett 520:167-70. 2002
    ....
  79. ncbi Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein
    Jerome Delplanque
    Laboratory of Physiological Chemistry, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 279:46606-13. 2004
    ..This finding, together with the high affinity of FN3K-RP for ribulosamines, suggests that this enzyme may serve to repair damage caused by the powerful glycating agent, ribose 5-phosphate...
  80. ncbi Steroid hormone regulation of EMP2 expression and localization in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Reprod Biol Endocrinol 6:15. 2008
    ..Because EMP2 is differentially expressed in the various stages of the murine and human estrous cycle, we tested the hypothesis that the steroid hormones progesterone and estrogen influence EMP2 expression and localization...
  81. ncbi Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats
    Takashi Ichiyanagi
    Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1, Higashijima, Niigata 956-8603, Japan
    J Agric Food Chem 54:6578-87. 2006
    ..The major anthocyanins distributed in liver and kidney were the O-methyl anthocyanins such as peonidin, malvidin, and other O-methyl anthocyanins derived from delphinidin, cyanidin, and petunidin-glycosides...
  82. ncbi Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    Sun Hwa Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    J Control Release 129:107-16. 2008
    ..This study demonstrates the feasibility of using PEC micelles as a potential carrier for therapeutic siRNAs in local and systemic treatment of cancer...
  83. ncbi Body distribution of polysorbate-80 and doxorubicin-loaded [14C]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats
    Alessandra Ambruosi
    , , Marie-Curie-Strabe 9, D-60439, Frankfurt am Main, Germany
    J Drug Target 13:535-42. 2005
    ..After longer time periods after injection the differences between the three preparations decreased...
  84. ncbi Identification and evaluation of a new tumor cell-binding peptide, FROP-1
    Sabine Zitzmann
    Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 48:965-72. 2007
    ....
  85. ncbi Transporters as a determinant of drug clearance and tissue distribution
    Yoshihisa Shitara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chou-ku, Chiba 260-8675, Japan
    Eur J Pharm Sci 27:425-46. 2006
    ..Double transfected cells, where both uptake and efflux transporters are expressed on the same polarized cells, are also helpful for the analysis of the rate of transporter-mediated transcellular transport...
  86. ncbi Monoclonal antibody pharmacokinetics and pharmacodynamics
    W Wang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, West Point, Pennsylvania, USA
    Clin Pharmacol Ther 84:548-58. 2008
    ..This article attempts to provide a brief overview of the main determinants of antibody pharmacokinetics and pharmacodynamics. Clinical Pharmacology & Therapeutics (2008); 84, 5, 548-558 doi:10.1038/clpt.2008.170...
  87. ncbi Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
    Elena Diaz-Rodriguez
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:16719-24. 2008
    ..These results underscore the role of chromosomal instability as a result of mitotic checkpoint hyperactivation in the initiation of tumorigenesis...
  88. ncbi Genomic structure and transcript variants of the bovine DAZL gene
    W S Liu
    Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
    Cytogenet Genome Res 116:65-71. 2007
    ..Our results lay the groundwork for possible single nucleotide polymorphism (SNP) and functional studies of the DAZL gene in cattle...
  89. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
    ..of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types...
  90. ncbi Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects
    Anita Schnyder
    University Hospital Basel, Department of Research and Division of Clinical Pharmacology, CH-4031, Basel, Switzerland
    J Drug Target 13:325-35. 2005
    ..Pharmacokinetics and tissue distribution studies in the rat revealed brain accumulation of daunomycin in OX26-immunoliposomes to higher levels as ..
  91. ncbi Regulation of expression of mammalian gonadotrophin-releasing hormone receptor genes
    J P Hapgood
    Department of Biochemistry, University of Stellenbosch, Matieland, South Africa
    J Neuroendocrinol 17:619-38. 2005
    ....
  92. ncbi Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
    Helder I Nakaya
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Genome Biol 8:R43. 2007
    ..However, the complement of human genes in which introns are transcribed, and the number of intronic transcriptional units and their tissue expression patterns are not known...
  93. ncbi cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice
    F I Raynaud
    Cancer Research Campaign Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Clin Cancer Res 3:2063-74. 1997
    ..AMD473 is entering Phase I clinical trials under the auspices of the United Kingdom Cancer Research Campaign in 1997...
  94. ncbi Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice
    Prateek Singh
    Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Dr H S Gour University Sagar, MP, India
    Bioconjug Chem 19:2239-52. 2008
    ..Tailoring of dendrimers via PEG-folic acid reduced hemolytic toxicity, which led to a sustained drug release pattern as well as highest accumulation in the tumor area...
  95. ncbi Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 65:622-31. 2005
    ..Thus, attenuating the Fc-FcRn interaction provides a way of controlling the antibody fragment serum half-life without compromising expression and tumor targeting...
  96. ncbi MBP-annexin V radiolabeled directly with iodine-124 can be used to image apoptosis in vivo using PET
    Bronwen Dekker
    Cancer Research UK/UMIST, Department of Radiochemical Targeting and Imaging, Paterson Institute for Cancer Research, M20 4BX Manchester, UK
    Nucl Med Biol 32:241-52. 2005
    ..In conclusion, we have shown that MBP-annexin V and the phosphatidylserine ELISA are useful tools for the development of methods for radiolabeling annexin V for PET imaging...
  97. ncbi Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase
    Sang-Yoon Lee
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nucl Med Commun 25:591-6. 2004
    ..In vitro autoradiography was performed by incubating rat brain coronal slices with [F]-1. Tissue distribution studies were performed in mouse brain and the data were expressed as the percentage of the injected dose ..
  98. ncbi Ionic interaction of [11C]-N,alpha-dimethylbenzylamine (DMBA) in rodent brain
    Osamu Inoue
    Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Osaka, Japan
    Ann Nucl Med 17:469-73. 2003
    ..These results indicate that the ionic binding component for DMBA exists mainly in neural cells rather than in glial cells. [11C]DMBA might be a useful radiotracer for detection of neural cell loss in the brain...
  99. ncbi Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing
    Paul P Lau
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:52988-96. 2003
    ....
  100. ncbi Molecular characterization of a phospholipase D generating anandamide and its congeners
    Yasuo Okamoto
    Department of Biochemistry, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    J Biol Chem 279:5298-305. 2004
    ..These results confirm that a specific phospholipase D is responsible for the generation of N-acylethanolamines including anandamide, strongly suggesting the physiological importance of lipid molecules of this class...
  101. ncbi Pharmacokinetics and metabolism of 5-125I-iodo-4'-thio-2'-deoxyuridine in rodents
    Jun Toyohara
    Research and Development Division, Research Center, Nihon Medi-Physics Co, Ltd, Chiba, Japan
    J Nucl Med 44:1671-6. 2003
    ..CONCLUSION: These data demonstrate that (125)I-ITdU is less susceptible against catabolism and readily incorporated into DNA in proliferating tissues. Therefore, (125)I-ITdU may be useful in measuring DNA synthesis with SPECT...

Research Grants87

  1. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that if appropriately developed, pyrrhocoricin derivatives ..
  2. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2010
    ..Our studies to date of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcriptional regulation, as well as the phenotype of our recently ..
  3. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    ..However, a crucial limitation of murine models of candidiasis is the need to sacrifice animals to determine tissue distribution of the fungus...
  4. PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORS
    Joel Linden; Fiscal Year: 1993
    ..We will clone putative subtypes of A1 and A2 receptors and will determine the tissue distribution of mRNA's by in situ hybridization...
  5. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  6. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  7. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2010
    ..Toxicity, dosing, and tissue distribution studies will be performed for fluorophore-conjugated monoclonal antibodies...
  8. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
  9. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
    ..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
  10. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005
    ..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
  11. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 2001
    ....
  12. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2007
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  13. Biological roles of galectins
    GERARDO RAUL VASTA; Fiscal Year: 2010
    ..tandem-repeat, and chimeric tandem-repeat galectins, and characterized their developmental expression and tissue distribution. We performed preliminary functional analyses: knockdown embryos for proto type galectins exhibit disrupted ..
  14. MOLECULAR BIOLOGY OF THE MARFAN SYNDROME
    Harry Dietz; Fiscal Year: 1999
    ..Variability in the age of onset, tissue distribution, and severity of manifestations is common both in and among families...
  15. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2007
    ..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  16. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2009
    ..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  17. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  18. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
  19. Endosymbiont, Arbovirus & Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2010
    ..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
  20. ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUS
    Charles Chavkin; Fiscal Year: 1993
    ..Substantial progress has been made in defining the molecular forms, tissue distribution, specific receptors, and pharmacological actions of the endogenous opioid peptides, yet little is known ..
  21. Body Composition & REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2007
    ..Using MRI, we will describe body composition changes at the tissue and organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
  22. Development of biomimetic oligomers as anti-coagulant antagonists
    Richard Scott; Fiscal Year: 2007
    ..have many advantages over peptides: relatively smaller size which increases stability and enhances tissue distribution, ease of synthesis, resistance to proteolytic degradation, and suitability for medicinal chemistry ..
  23. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2010
    ..and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, and a peptide- binding specificity like HLA-A*02...