tissue distribution

Summary

Summary: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Top Publications

  1. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
  2. pmc Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
  3. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
  4. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
  5. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
  6. pmc Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
  7. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  8. doi In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    Zhuang Liu
    Nat Nanotechnol 2:47-52. 2007
  9. ncbi Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
  10. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008

Detail Information

Publications342 found, 100 shown here

  1. ncbi Drug delivery systems: entering the mainstream
    Theresa M Allen
    Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
    Science 303:1818-22. 2004
    ..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
  2. pmc Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    Daniel Globisch
    Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
    PLoS ONE 5:e15367. 2010
    ..Additionally, we show using HPLC-MS analysis and immunohistochemistry that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS...
  3. pmc Factors affecting the clearance and biodistribution of polymeric nanoparticles
    Frank Alexis
    Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pharm 5:505-15. 2008
    ....
  4. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    ..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
  5. ncbi Particle size-dependent organ distribution of gold nanoparticles after intravenous administration
    Wim H De Jong
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
    Biomaterials 29:1912-9. 2008
    A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
  6. pmc Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice
    Jun Wang
    Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 5:861-6. 2010
    This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.
  7. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  8. doi In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
    Zhuang Liu
    Nat Nanotechnol 2:47-52. 2007
  9. ncbi Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay
    J D Wadsworth
    MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
    Lancet 358:171-80. 2001
    ..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...
  10. ncbi Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats
    Yong Soon Kim
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:575-83. 2008
    ..Nonetheless, the tissue distribution of silver nanopaticles did show a dose-dependent accumulation of silver content in all the tissues examined...
  11. ncbi Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    A H Schinkel
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cell 77:491-502. 1994
    ....
  12. pmc Gold nanoparticles: a revival in precious metal administration to patients
    A S Thakor
    Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California 94305 5427, United States
    Nano Lett 11:4029-36. 2011
    ..The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed...
  13. ncbi The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
    Sharmilee Gnanapavan
    Department of Endocrinology, St Bartholomew s and The Royal London Hospital, London ECIA 7BE, UK
    J Clin Endocrinol Metab 87:2988. 2002
    ..GHS-R1b expression was also widespread in all tissues studied. The significance of the widespread tissue distribution of ghrelin remains to be determined...
  14. ncbi Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery
    Giulio F Paciotti
    CytImmune Sciences, Inc, College Park, Maryland 20740, USA
    Drug Deliv 11:169-83. 2004
    ..Finally, PT-cAu-TNF was less toxic and more effective in reducing tumor burden than native TNF since maximal antitumor responses were achieved at lower doses of drug...
  15. ncbi Identification of tissue-specific microRNAs from mouse
    Mariana Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Curr Biol 12:735-9. 2002
    ..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...
  16. pmc Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
    Parag Aggarwal
    Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
    Adv Drug Deliv Rev 61:428-37. 2009
    ..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution...
  17. ncbi Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    Nikki Parker
    Endocyte Inc, West Lafayette, IN 47906, USA
    Anal Biochem 338:284-93. 2005
    ..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...
  18. ncbi Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    Itai Yanai
    Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
    Bioinformatics 21:650-9. 2005
    ..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...
  19. doi The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    Minjung Cho
    Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Lett 189:177-83. 2009
    ..and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo...
  20. doi Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies
    Nikolai Khlebtsov
    Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
    Chem Soc Rev 40:1647-71. 2011
    ....
  21. ncbi Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
    Ronald J Jandacek
    Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
    Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005
    ..Distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra...
  22. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  23. ncbi Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study
    Jimena Cazenave
    Universidad Nacional de Cordoba, Facultad de Ciencias Exactas, Fisicas y Naturales, Cátedra Diversidad Animal II, Velez Sarsfield 299, 5000 Cordoba, Argentina
    Aquat Toxicol 75:178-90. 2005
    ..These findings also raise questions on the probable neurotoxicity of microcystins...
  24. pmc Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 28:869-76. 2007
    ..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
  25. doi Biodistribution and toxicity of intravenously administered silica nanoparticles in mice
    Guangping Xie
    Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arch Toxicol 84:183-90. 2010
    ..Here we investigated the long-term (30 days) quantitative tissue distribution, and subcellular distribution, as well as potential toxicity of two sizes of intravenously administered ..
  26. ncbi Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection
    P Laverman
    Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 298:607-12. 2001
    ..Therefore, these findings may have a considerable impact on the clinical application of liposomal formulations that are administered repeatedly...
  27. ncbi Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
    J Mol Endocrinol 35:283-92. 2005
    ....
  28. doi Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
    Wan Seob Cho
    Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Appl Pharmacol 236:16-24. 2009
    ..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...
  29. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
    ..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
  30. ncbi Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction
    Won Jun Kang
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nucl Med 47:1295-301. 2006
    ..The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG.
  31. doi Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration
    Cheng Feng Luo
    The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510260, China
    Int J Pharm 410:138-44. 2011
    ..The objective of this study was to investigate the pharmacokinetics, tissue distribution and relative bioavailability of puerarin in rats after a single dose intragastric administration of ..
  32. doi PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
    Yuta Yoshizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Int J Pharm 412:132-41. 2011
    ..These results suggest that PEG liposome would serve as a potent PTX delivery vehicle for the future cancer chemotherapy...
  33. ncbi Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles
    J F Hillyer
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
    J Pharm Sci 90:1927-36. 2001
    ..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
  34. doi Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions
    Lei Gao
    Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China
    Int J Pharm 355:321-7. 2008
    The purpose of the present study was to investigate the effects of particle size on the pharmacokinetics and tissue distribution of oridonin nanosuspensions after intravenous administration...
  35. ncbi A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation
    B S Kwon
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 272:14272-6. 1997
    ..A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation...
  36. ncbi The kinetics of the tissue distribution of silver nanoparticles of different sizes
    D P K Lankveld
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Biomaterials 31:8350-61. 2010
    Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...
  37. doi Anti-inflammatory properties of cerium oxide nanoparticles
    Suzanne M Hirst
    Center for Molecular Medicine and Infectious Diseases CMMID, 1410 Prices Fork Blacksburg, VA 24060, USA
    Small 5:2848-56. 2009
    ..Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation...
  38. pmc P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
    A H Schinkel
    The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 97:2517-24. 1996
    ..b>Tissue distribution studies demonstrated that the relative brain penetration of radiolabeled ondansetron and loperamide (and ..
  39. ncbi Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors
    Y Coulouarn
    European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
    FEBS Lett 457:28-32. 1999
    ..In situ hybridization histochemistry showed that the prepro-UII gene is predominantly expressed in motoneurons of the brainstem and spinal cord, suggesting that UII may play a role in the control of neuromuscular functions...
  40. ncbi Axon tracts correlate with netrin-1a expression in the zebrafish embryo
    J D Lauderdale
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Mol Cell Neurosci 9:293-313. 1997
    ..These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways...
  41. pmc Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    Henrik Nordman
    Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
    Biochem J 364:191-200. 2002
    ..Following ion-exchange HPLC, both MUC5AC and MUC6 appeared as several distinct populations, probably corresponding to 'glycoforms' of the mucins, the most highly charged of which were found in the gland tissue...
  42. ncbi Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome
    Noriyuki Maeda
    Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    J Control Release 100:41-52. 2004
    ..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...
  43. ncbi Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours
    Andreas Helisch
    Department of Nuclear Medicine, University of Mainz, Mainz, Germany
    Eur J Nucl Med Mol Imaging 31:1386-92. 2004
    ....
  44. doi A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
    Jasmine P Davda
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Int Immunopharmacol 8:401-13. 2008
    ..The model gave satisfactory predictions of CC49 disposition and tumor uptake in man...
  45. ncbi 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation
    Raffaella Rossin
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 46:1210-8. 2005
    ..The purpose of this study was to evaluate 64Cu-radiolabeled folate-conjugated shell cross-linked nanoparticles (SCKs) as candidate agents to shuttle radionuclides and drugs into tumors overexpressing the folate receptor (FR)...
  46. ncbi Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size
    Ganeshchandra Sonavane
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
    Colloids Surf B Biointerfaces 66:274-80. 2008
    ..The results revealed that tissue distribution of gold nanoparticles is size-dependent with the smallest 15 nm nanoparticles showing the most widespread ..
  47. pmc Rapid translocation of nanoparticles from the lung airspaces to the body
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Biotechnol 28:1300-3. 2010
    ..We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis...
  48. doi Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze)
    Shao Hua Gu
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Insect Biochem Mol Biol 41:254-63. 2011
    ..The possible physiological functions of these OBPs are discussed...
  49. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  50. ncbi Tissue distribution of quercetin in rats and pigs
    Vincent C J de Boer
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    J Nutr 135:1718-25. 2005
    ..To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0...
  51. ncbi Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    Alexandra Aicher
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 107:2134-9. 2003
    ..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals...
  52. doi Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats
    Suresh K Balasubramanian
    Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
    Biomaterials 31:2034-42. 2010
    ..These results demonstrate that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs...
  53. ncbi Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
    Paolo Caliceti
    Department of Pharmaceutical Sciences, University of Padua, Via F Marzolo 5, 35131 Padova, Italy
    Adv Drug Deliv Rev 55:1261-77. 2003
    ..The examples reported in this review show that general considerations could be useful in developing a target product, although significant deviations from the expected results can not be excluded...
  54. pmc Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels
    Erik S Mittra
    Molecular Imaging Program, Department of Radiology, Division of Nuclear Medicine, Stanford Hospital and Clinics, 300 Pasteur Dr, Room H2200, Stanford, CA 94305 5281, USA
    Radiology 260:182-91. 2011
    ....
  55. ncbi Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse
    J F Couse
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 138:4613-21. 1997
    ..of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types...
  56. pmc Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomes
    Wei Zhao
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Int J Nanomedicine 6:3087-98. 2011
    ..Caution should be exercised when chemotherapeutic drugs are loaded into CLP for tumor therapy...
  57. pmc Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition
    Wilhelm Palm
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    PLoS Genet 8:e1002828. 2012
    ..These studies define major routes of interorgan lipid transport in Drosophila and uncover surprising tissue-specific differences in lipoprotein lipid utilization...
  58. ncbi Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utility
    Maurice M A L Pelsers
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Clin Chem 50:1568-75. 2004
    ..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and ..
  59. doi Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution
    Evin Gultepe
    Northeastern University, Boston, MA, USA
    Nanomedicine (Lond) 5:1173-82. 2010
    ....
  60. doi Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting
    Joost Westerhout
    Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Pharm Sci 100:3577-93. 2011
    ..g., inhibition of an efflux transporter or induction of pathological state). With the use of advanced mathematical modeling procedures, we may dissect contributions of individual mechanisms in animals as links to the human situation...
  61. doi Analysis of cause of failure of new targeting peptide in PEGylated liposome: molecular modeling as rational design tool for nanomedicine
    Julia Lehtinen
    Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Eur J Pharm Sci 46:121-30. 2012
    ..We know of no means to investigate this experimentally with atomic level resolution, thus our use of computational methods to investigate this can be seen as a new tool for rational design in nanomedicine...
  62. doi Effects of charge on antibody tissue distribution and pharmacokinetics
    C Andrew Boswell
    Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Research and Early Development, South San Francisco, California 94080, USA
    Bioconjug Chem 21:2153-63. 2010
    ..I) shifts in isoelectric point of approximately one pI unit or more can produce measurable changes in tissue distribution and kinetics, (II) increases in net positive charge generally result in increased tissue retention and ..
  63. pmc Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, United States
    ACS Nano 5:4131-44. 2011
    ..Further endowment of this multifunctional drug delivery platform with targeting ligands and nanovalves may further enhance cell-specific targeting and on-demand release...
  64. ncbi Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme
    A L Albiston
    Baker Institute of Medical Research, Prahran, Melbourne, Australia
    Mol Cell Endocrinol 105:R11-7. 1994
    ..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids...
  65. ncbi Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats
    Holger Fuchs
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Birkendorfer Str 65, 88397 Biberach Riss, Germany
    Biopharm Drug Dispos 30:229-40. 2009
    ..In order to test these hypotheses, the tissue distribution of BI 1356 was determined in wild-type and DPP-4 deficient rats at different dose levels by means of whole ..
  66. ncbi Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging
    K H Lee
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Nucl Med Commun 24:1003-9. 2003
    ..Thus, substrate availability should be considered as a potential limiting factor for photon emission efficiency in certain organs when attempting quantitative interpretation of optical luc gene imaging...
  67. pmc Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
    Siva K Nalabotu
    Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25755 1090, USA
    Int J Nanomedicine 6:2327-35. 2011
    ..Herein, we examine if a single intratracheal instillation of CeO(2) nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats...
  68. ncbi Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
    Hanwen Zhang
    Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
    Cancer Res 64:6707-15. 2004
    ....
  69. ncbi Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles
    K Avgoustakis
    Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion 26500, Patras, Greece
    Int J Pharm 259:115-27. 2003
    ..This may be associated with the effects of the mPEG/PLGA ratio on the density of PEG on the surface of the nanoparticles and on the size of the nanoparticles...
  70. ncbi Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion
    Haiping Hao
    Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China
    Planta Med 72:1311-7. 2006
    This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza...
  71. pmc Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration
    Elsa M Janle
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
    J Med Food 13:926-33. 2010
    ..To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell ..
  72. pmc Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy
    Brandon Kwong
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Mass Ave, Cambridge, MA 02139, USA
    Biomaterials 32:5134-47. 2011
    ..The development of a delivery strategy capable of inducing robust anti-tumor responses concurrent with minimal systemic side effects is crucial for the continued progress of potent immunotherapies toward widespread clinical translation...
  73. ncbi Whole-body physiologically based pharmacokinetic models
    Ivan Nestorov
    ZymoGenetics Inc, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
    Expert Opin Drug Metab Toxicol 3:235-49. 2007
    ....
  74. doi In vivo PET imaging and biodistribution of radiolabeled gold nanoshells in rats with tumor xenografts
    Huan Xie
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburn St, Houston, TX 77004, United States
    Int J Pharm 395:324-30. 2010
    ..Overall, PET images with (64)Cu had good resolution and therefore can be further applied to guide photothermal treatment of cancer...
  75. ncbi Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
    Angie L Bookout
    Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, 75390, USA
    Cell 126:789-99. 2006
    ..These data reveal a hierarchical transcriptional circuitry that extends beyond individual tissues to form a meganetwork governing physiology on an organismal scale...
  76. pmc A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeleton
    Nancy Braverman
    Department of Human Genetics and Pediatrics, Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada
    Mol Genet Metab 99:408-16. 2010
    ..The role of plasmalogens in the normal function of these tissues at various ages can now be studied and additional therapeutic interventions tested in this model...
  77. pmc Evaluation of iron oxide nanoparticle biocompatibility
    Amel Hanini
    Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
    Int J Nanomedicine 6:787-94. 2011
    ..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
  78. ncbi Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
    Amit Garg
    Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, Buffalo, NY 14260, USA
    J Pharmacokinet Pharmacodyn 34:687-709. 2007
    ..functions to protect immune gamma globulin (IgG) from elimination, the influence of FcRn on the tissue distribution of IgG has not been quantified...
  79. ncbi Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits
    V D Awasthi
    Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Int J Pharm 253:121-32. 2003
    ..Beyond this range, the stealth property of PEG-liposomes is significantly compromised and the distribution is characterized by high RES accumulation...
  80. ncbi Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats
    Eric Fabian
    BASF Product Safety, BASF Aktiengesellschaft, Ludwigshafen, Germany
    Arch Toxicol 82:151-7. 2008
    The tissue distribution and toxicity of intravenously administered nanoparticles of titanium dioxide (TiO2) (>10 wt...
  81. ncbi SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
    ..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
  82. ncbi Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice
    J Dowling
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, Chicago, Illinois 60637, USA
    Dev Biol 187:131-42. 1997
    ..Collectively, our findings suggest a mechanism for the BPAG1 null phenotype and indicate that different neurons respond differently to the absence of BPAG1-n, a cytoskeletal linker protein...
  83. ncbi Cloning and functional expression of a human liver organic cation transporter
    L Zhang
    Department of Biopharmaceutical Sciences, University of California San Francisco 94143, USA
    Mol Pharmacol 51:913-21. 1997
    ..In comparison to rOCT1, hOCT1 exhibits notable differences in its kinetic characteristics and tissue distribution. The functional expression of hOCT1 will provide a powerful tool for elucidation of the mechanisms of ..
  84. ncbi Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers
    A F Ruchon
    Departement de Biochimie, Universite de Montreal, Canada
    J Bone Miner Res 15:1440-50. 2000
    ..We characterized the developmental expression and tissue distribution of Phex protein, using a monoclonal antibody against human PHEX, examined the effect of the Hyp mutation on ..
  85. ncbi High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Cancer Res 59:2635-43. 1999
    ..Due to its short physical half-life, 213Bi appears to be especially suitable for use in conjunction with fast-clearing fragments...
  86. ncbi Inhibition of cancer growth by resveratrol is related to its low bioavailability
    Miguel Asensi
    Departamento de Fisiologia, Universidad de Valencia, Valencia, Spain
    Free Radic Biol Med 33:387-98. 2002
    ....
  87. pmc Cell-type-specific signatures of microRNAs on target mRNA expression
    Pranidhi Sood
    Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 103:2746-51. 2006
    ..We show that this tool can identify functionally important 3' UTR motifs without cross-species comparison...
  88. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002
    ..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
  89. ncbi Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives
    Martin Behe
    Department of Nuclear Medicine, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
    Eur J Nucl Med Mol Imaging 30:1140-6. 2003
    ..DTPA- dGlu(1)-minigastrin is preferred to "monofunctional" DTPA-Leu(1)-minigastrin for diagnostic application with (111)In for the in vivo detection of CCK-B receptor-expressing tissues...
  90. ncbi PET of EGFR antibody distribution in head and neck squamous cell carcinoma models
    Gang Niu
    Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
    J Nucl Med 50:1116-23. 2009
    ....
  91. pmc Modelling and PBPK simulation in drug discovery
    Hannah M Jones
    Pfizer Global R and D, Department of Pharmacokinetics, Dynamics and Metabolism, IPC 654, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
    AAPS J 11:155-66. 2009
    ..Specific reference is made to its utility (1) at the lead development stage for the prioritization of compounds for animal PK studies and (2) at the clinical candidate selection and "first in human" stages for the prediction of human PK...
  92. ncbi Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
    Cancer Res 67:718-26. 2007
    ..Finally, the 125I/111In biodistribution data allowed for dose estimations, which suggest the 131I-labeled scFv-Fc H310A/H435Q as a promising candidate for radioimmunotherapy...
  93. ncbi A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humans
    G Carrier
    Chair in Toxicological Risk Assessment for Human Health, Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, Main Station, Montreal, Quebec, H3C 3J7, Canada
    Toxicol Appl Pharmacol 171:50-60. 2001
    ..Thus, accessible measurements on these matrices allow inferences of past, present, and future burdens. This could prove to be a useful tool in assessing the health risks associated with various circumstances of methyl mercury exposure...
  94. ncbi Antisense therapeutics
    S Agrawal
    Hybridon Inc, Cambridge, MA 02139, USA
    Curr Opin Chem Biol 2:519-28. 1998
    ..Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously...
  95. ncbi Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
    A Musaro
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
    Nat Genet 27:195-200. 2001
    ..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
  96. doi Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity
    Wei Wu
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People s Republic of China
    ACS Nano 3:2740-50. 2009
    ....
  97. pmc In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer
    Emilia S Olson
    Department of Pharmacology, La Jolla, CA 92093 0647, USA
    Integr Biol (Camb) 1:382-93. 2009
    ..Our results validate an approach that should generally deliver imaging agents and chemotherapeutics to sites of invasion, tumor-promoting inflammation, and metastasis...
  98. ncbi Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14 C-bortezomib
    Alex Hemeryck
    Global Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, A Division of Janssen Pharmaceutica N V, Beerse, Belgium
    Cancer Chemother Pharmacol 60:777-87. 2007
    ..The body distribution of total radioactivity (TR) and bortezomib was investigated in male Sprague-Dawley rats after single and repeated i.v. (bolus) administration with (14)C-labelled bortezomib (VELCADE) (0.2 mg/kg; 0.28 MBq./kg)...
  99. doi Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons
    Marjo Piltonen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
    Exp Neurol 219:499-506. 2009
    ..The results imply that GDNF binding to HSs is needed for the optimum neuroprotective effect...
  100. ncbi Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge
    Y Yamamoto
    Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
    J Control Release 77:27-38. 2001
    ....
  101. ncbi Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs
    Theodosia Maina
    Institute of Radioisotopes Radiodiagnostic Products, National Center for Scientific Research Demokritos, 152 10 Ag Paraskevi Arrikis, Athens, Greece
    J Nucl Med 46:823-30. 2005
    ....

Research Grants91

  1. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that if appropriately developed, pyrrhocoricin derivatives ..
  2. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  3. SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER
    Joseph Robertson; Fiscal Year: 2009
    ..Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations. ..
  4. SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER
    Joseph Robertson; Fiscal Year: 2009
    ..There is a mass spectrophotometer room and a tissue distribution area;a Research Library;a bioengineering laboratory that supplies specialized technological laboratories;..
  5. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    ..properties of the compound in an intracavitary hemorrhage military-relevant animal model (pig), study tissue distribution, pharmacokinetics, reabsorption and toxicity of HAF...
  6. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..They are evolutionarily highly conserved (found in nematodes and mammals), and some show wide tissue distribution, while others are more selectively expressed by tissue...
  7. Targeting Galectin-3 with novel drugs for treatment of eczema
    Swey Shen Chen; Fiscal Year: 2009
    ..They are evolutionarily highly conserved (found in nematodes and mammals), and some show wide tissue distribution, while others are more selectively expressed by tissue...
  8. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Sherry Chow; Fiscal Year: 2010
    ..Due to their polarity, the tissue distribution of these metabolites is likely to be limited, thus limiting their in vivo tissue activities...
  9. Clinical Study of Disposition and Biological Activity of d-Limonene
    H H Chow; Fiscal Year: 2009
    ..Due to their polarity, the tissue distribution of these metabolites is likely to be limited, thus limiting their in vivo tissue activities...
  10. Advancing lead dipiperidine compound into preclinical development
    Marina Protopopova; Fiscal Year: 2009
    ..parameters of SQ609 and bioavailability in mice following both IV and PO administration, and the tissue distribution profile of the drug in mice after single dosing...
  11. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2010
    ..Our studies to date of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcriptional regulation, as well as the phenotype of our recently ..
  12. SPHINGOLIPID METABOLISM AND BRAIN DEVELOPMENT
    Yasuo Kishimoto; Fiscal Year: 1991
    ..Their physiological significance is suggested by a wide tissue distribution, subcellular localization which includes nuclei, conservation during evolution, and of particular relevance ..
  13. Creation and validation of a lux-positive Candida strain
    Yue Fu; Fiscal Year: 2007
    ..However, a crucial limitation of murine models of candidiasis is the need to sacrifice animals to determine tissue distribution of the fungus...
  14. PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORS
    Joel Linden; Fiscal Year: 1993
    ..We will clone putative subtypes of A1 and A2 receptors and will determine the tissue distribution of mRNA's by in situ hybridization...
  15. PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORS
    Joel Linden; Fiscal Year: 1992
    ..We will clone putative subtypes of A1 and A2 receptors and will determine the tissue distribution of mRNA's by in situ hybridization...
  16. Saxitoxin-Antibody Conjugates as Tools for Na+ Ion Channel Study and Therapeutics
    JUSTIN DU BOIS; Fiscal Year: 2010
    ..1- 1.9 and NaX), each having unique biophysical characteristics, and cellular and tissue distribution patterns. Drugs that inhibit NaVs non-specifically (e.g...
  17. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2003
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  18. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  19. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2004
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  20. Phytoestrogens as an alternative treatment for MS
    Bruce Bebo; Fiscal Year: 2005
    ..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
  21. Optimization of SWCNT/siRNA complex formulation for tumor accumulation
    Lynn Kirkpatrick; Fiscal Year: 2012
    ..a comprehensive examination of a number of formulations of SWCNT/siRNA to determine their tumor and tissue distribution following intravenous administration...
  22. Fluorophore-Conjugated Antibodies for Imaging and Resection of GI Tumors
    Meng Yang; Fiscal Year: 2010
    ..Toxicity, dosing, and tissue distribution studies will be performed for fluorophore-conjugated monoclonal antibodies...
  23. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
  24. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2007
    ..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
  25. BIOLOGY OF SIALIC ACIDS AND THEIR SUBSTITUTIONS
    Ajit Varki; Fiscal Year: 1999
    ..We now propose to focus upon the following: 1. Compare the tissue distribution of 9-O-acetylation, among four mammalian species.This is made possible by a CHE-based probe...
  26. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2011
    ..For selected formulations, radioactive bryostatin 1 will be assayed to determine the pharmacokinetics and tissue distribution. Pharmacologic efficacy will also be measured, particularly in the brain and plasma compartments by total ..
  27. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2010
    ..For selected formulations, radioactive bryostatin 1 will be assayed to determine the pharmacokinetics and tissue distribution. Pharmacologic efficacy will also be measured, particularly in the brain and plasma compartments by total ..
  28. AZIDE TECHNOLOGY FOR DRUG DEVELOPMENT
    Kyoichi Watanabe; Fiscal Year: 2001
    ..nucleoside can act as a slow releaser of the active antiviral drug with very favorable plasma half-life, tissue distribution and pharmacokinetics...
  29. FETAL MEMBRANE MATRIX METALLOPROTEINASES IN MONKEYS SPONTANE & ACTH INDUCE LABO
    DREW SADOWSKY; Fiscal Year: 2000
    ..Two isoforms of the E receptor (ER ? and ?) have been reported. To study the tissue distribution of the ER isoforms, we cloned and sequenced two cDNA probes (126 bp and 291 bp) for rhesus monkey ER-?...
  30. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2003
    ..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
  31. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2005
    ..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
  32. Nutritional Biochemistry of beta-Carotene Dioxygenase
    A Andersson; Fiscal Year: 2004
    ..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
  33. Ligand-Assisted Structural Studies of the Human Cannabinoid Receptor 2, Using NMR
    Elvis K Tiburu; Fiscal Year: 2010
    ..The tissue distribution and integrated activities of CB receptors and eCB biosynthetic and metabolizing enzymes are key to ..
  34. IGE BINDING PROTEIN--A MULTIFUNCTIONAL ANIMAL LECTIN
    Fu Tong Liu; Fiscal Year: 1993
    ..The protein has wide tissue distribution, is found on the cell surface and also secreted under certain conditions...
  35. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 1993
    ....
  36. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 1992
    ....
  37. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 1999
    ....
  38. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 2001
    ....
  39. COMPLEX CARBOHYDRATES OF NERVOUS TISSUE
    RICHARD MARGOLIS; Fiscal Year: 2000
    ....
  40. DEVELOPMENT AND REGULATION OF NATURAL KILLER CELLS
    Yoon Kim; Fiscal Year: 1992
    ..1) Further characterization of porcine NK function-associated PNK-E and G7 molecules: determine cell and tissue distribution of PNK-E and G7 mAb enhanced NK activity and of PNK-E+ and G7+ cells; biochemical characterization of PNK-E ..
  41. FLUORESCENCE-BASED STUDIES OF SPHINGOMYELIN AND CERAMIDE
    EDWARD SCHUCHMAN; Fiscal Year: 2002
    ..g., uptake, tissue distribution, etc) of the fluorescent enzyme will be monitored in cells and animals...
  42. FLUORESCENCE-BASED STUDIES OF SPHINGOMYELIN AND CERAMIDE
    EDWARD SCHUCHMAN; Fiscal Year: 2000
    ..g., uptake, tissue distribution, etc) of the fluorescent enzyme will be monitored in cells and animals...
  43. FLUORESCENCE-BASED STUDIES OF SPHINGOMYELIN AND CERAMIDE
    EDWARD SCHUCHMAN; Fiscal Year: 2001
    ..g., uptake, tissue distribution, etc) of the fluorescent enzyme will be monitored in cells and animals...
  44. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2012
    ..However, while AMPs have good antimicrobial activity, problems with tissue distribution and toxicity have presented obstacles to translating this expensive class of peptides into drugs...
  45. Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and Susceptib
    Richard W Scott; Fiscal Year: 2010
    ..However, while AMPs have good antimicrobial activity, problems with tissue distribution and toxicity have presented obstacles to translating this expensive class of peptides into drugs...
  46. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2004
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  47. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2006
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  48. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2003
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  49. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2005
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  50. DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENT
    George Painter; Fiscal Year: 2007
    ..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
  51. REGULATION OF GENE EXPRESSION IN PHAGOCYTIC CELLS
    DAVID SKALNIK; Fiscal Year: 1993
    ....
  52. Biological roles of galectins
    GERARDO RAUL VASTA; Fiscal Year: 2010
    ..tandem-repeat, and chimeric tandem-repeat galectins, and characterized their developmental expression and tissue distribution. We performed preliminary functional analyses: knockdown embryos for proto type galectins exhibit disrupted ..
  53. ACTIONS OF INSECTICIDES ON SODIUM CHANNEL ISOFORMS
    DAVID SODERLUND; Fiscal Year: 1999
    ..Sodium channels exist in multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  54. ACTIONS OF INSECTICIDES ON SODIUM CHANNEL ISOFORMS
    DAVID SODERLUND; Fiscal Year: 2000
    ..Sodium channels exist in multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  55. ATHEROGENICITY OF POSTPRANDIAL TRIGLYCRIDE-RICH LIPOPROTEINS (PPTGRLP)
    SANDRA GIANTURCO; Fiscal Year: 2000
    ..The cell and tissue distribution in humans appears restricted to reticuloendothelial cells: monocytes, macrophages, placenta, bone marrow, ..
  56. MOLECULAR BIOLOGY OF THE MARFAN SYNDROME
    Harry Dietz; Fiscal Year: 1999
    ..Variability in the age of onset, tissue distribution, and severity of manifestations is common both in and among families...
  57. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2009
    ..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  58. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2007
    ..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
  59. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2003
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  60. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2001
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  61. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  62. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2000
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  63. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2002
    ..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
  64. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
  65. CIC-3 channels in regulation of cell volume/shape in PMN
    Jessica Moreland; Fiscal Year: 2006
    ..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
  66. Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
    Jerry Ingrande; Fiscal Year: 2011
    ..coronary artery disease, and mortality, and accounts for changes in regional blood flow, adipose tissue distribution, and cardiac function...
  67. Endosymbiont, Arbovirus & Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2010
    ..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
  68. Endosymbiont, Arbovirus & Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2009
    ..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
  69. Interferon Effects on HIV Transmission in Human Models
    Judy Lieberman; Fiscal Year: 2012
    ..Our first aim is to characterize the cell types, phenotype and tissue distribution of infiltrating hematopoietic cells in normal human cervix and compare it with the distribution of human ..
  70. ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUS
    Charles Chavkin; Fiscal Year: 1992
    ..Substantial progress has been made in defining the molecular forms, tissue distribution, specific receptors, and pharmacological actions of the endogenous opioid peptides, yet little is known ..
  71. ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUS
    Charles Chavkin; Fiscal Year: 1993
    ..Substantial progress has been made in defining the molecular forms, tissue distribution, specific receptors, and pharmacological actions of the endogenous opioid peptides, yet little is known ..
  72. ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUS
    Charles Chavkin; Fiscal Year: 1991
    ..Substantial progress has been made in defining the molecular forms, tissue distribution, specific receptors, and pharmacological actions of the endogenous opioid peptides, yet little is known ..
  73. Body Composition & REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2005
    ..Using MRI, we will describe body composition changes at the tissue and organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
  74. Body Composition & REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2006
    ..Using MRI, we will describe body composition changes at the tissue and organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
  75. Body Composition & REE Responses to Bariatric Surgeries
    Dympna Gallagher; Fiscal Year: 2007
    ..Using MRI, we will describe body composition changes at the tissue and organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
  76. A Topical Host Defense Peptide Mimetic for Oral Mucositis
    Richard W Scott; Fiscal Year: 2012
    ..These small synthetic oligomers are less expensive to produce, have better tissue distribution than HDPs, and are easier to fine-tune structurally to improve activity and minimize toxicity...
  77. MOLECULAR ANALYSIS OF HUMAN SALIVARY CYSTATIN GENES
    Douglas Dickinson; Fiscal Year: 1990
    ..The multiplicity of type 2 cystatins in humans, their wide tissue distribution, the variation in their relative levels in different sites, and their relative conservation of protein ..
  78. MECHANISM OF ACTION OF ANTI-TUMOR DRUGS
    Richard Luduena; Fiscal Year: 1991
    ..subunits: alpha and beta, both of which occur as multiple isotypes exhibiting great differences in their tissue distribution. Because of its role in mitosis, tubulin is the target for a variety of anti-tumor drugs...
  79. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2010
    ..and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, and a peptide- binding specificity like HLA-A*02...
  80. Development of biomimetic oligomers as anti-coagulant antagonists
    Richard Scott; Fiscal Year: 2007
    ..have many advantages over peptides: relatively smaller size which increases stability and enhances tissue distribution, ease of synthesis, resistance to proteolytic degradation, and suitability for medicinal chemistry ..
  81. FUNCTIONAL STUDIES ON THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR
    Dudley Strickland; Fiscal Year: 2000
    ..sequence homology with the LDL receptor, the VLDL receptor differs from the LDL receptor in its tissue distribution, and its ligand binding specificity...
  82. FUNCTIONAL STUDIES ON THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR
    Dudley Strickland; Fiscal Year: 1999
    ..sequence homology with the LDL receptor, the VLDL receptor differs from the LDL receptor in its tissue distribution, and its ligand binding specificity...
  83. MOLECULAR ANALYSIS OF ANTIGENIC VARIATION IN PLASMODIUM
    Mary Galinski; Fiscal Year: 2000
    ..mucin epitopes was tested in chimpanzees because they express the same molecule with the same sequence and tissue distribution. In preparation for the in vivo studies we obtained blood samples from various animals at the time they ..