Genomes and Genes
Summary: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Publications342 found, 100 shown here
- Drug delivery systems: entering the mainstreamTheresa M Allen
Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada
Science 303:1818-22. 2004..Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics...
- Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediatesDaniel Globisch
Department of Chemistry, Ludwig Maximilians University, Center for Integrated Protein Science, Munich, Germany
PLoS ONE 5:e15367. 2010..Additionally, we show using HPLC-MS analysis and immunohistochemistry that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS...
- Factors affecting the clearance and biodistribution of polymeric nanoparticlesFrank Alexis
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Pharm 5:505-15. 2008....
- Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetrationYin Meng Tsai
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
Int J Pharm 416:331-8. 2011..These findings provide further understanding for the possible therapeutic effects of curcumin and C-NPs in further pre-clinical and clinical research...
- Particle size-dependent organ distribution of gold nanoparticles after intravenous administrationWim H De Jong
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, Bilthoven, The Netherlands
Biomaterials 29:1912-9. 2008A kinetic study was performed to determine the influence of particle size on the in vivo tissue distribution of spherical-shaped gold nanoparticles in the rat...
- Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in miceJun Wang
Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People s Republic of China
Int J Nanomedicine 5:861-6. 2010This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.
- Toxic potential of materials at the nanolevelAndre Nel
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Science 311:622-7. 2006..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
- In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in miceZhuang Liu
Nat Nanotechnol 2:47-52. 2007
- Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assayJ D Wadsworth
MRC Prion Unit and Department of Neurogenetics, Imperial College School of Medicine at St Mary s, Norfolk Place, W2 1PG, London, UK
Lancet 358:171-80. 2001..We aimed to improve immunoblotting methods for high sensitivity detection of PrP(Sc) to investigate the distribution of PrP(Sc) in a range of vCJD tissues...
- Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley ratsYong Soon Kim
Korea Environment and Merchandise Testing Institute, Incheon, Korea
Inhal Toxicol 20:575-83. 2008..Nonetheless, the tissue distribution of silver nanopaticles did show a dose-dependent accumulation of silver content in all the tissues examined...
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsA H Schinkel
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
Cell 77:491-502. 1994....
- Gold nanoparticles: a revival in precious metal administration to patientsA S Thakor
Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, California 94305 5427, United States
Nano Lett 11:4029-36. 2011..The importance of controlling the size and shape of gold nanoparticles to minimize any potential toxic side effects is also discussed...
- The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humansSharmilee Gnanapavan
Department of Endocrinology, St Bartholomew s and The Royal London Hospital, London ECIA 7BE, UK
J Clin Endocrinol Metab 87:2988. 2002..GHS-R1b expression was also widespread in all tissues studied. The significance of the widespread tissue distribution of ghrelin remains to be determined...
- Colloidal gold: a novel nanoparticle vector for tumor directed drug deliveryGiulio F Paciotti
CytImmune Sciences, Inc, College Park, Maryland 20740, USA
Drug Deliv 11:169-83. 2004..Finally, PT-cAu-TNF was less toxic and more effective in reducing tumor burden than native TNF since maximal antitumor responses were achieved at lower doses of drug...
- Identification of tissue-specific microRNAs from mouseMariana Lagos-Quintana
Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
Curr Biol 12:735-9. 2002..Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA...
- Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacyParag Aggarwal
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Adv Drug Deliv Rev 61:428-37. 2009..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution...
- Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assayNikki Parker
Endocyte Inc, West Lafayette, IN 47906, USA
Anal Biochem 338:284-93. 2005..Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics...
- Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specificationItai Yanai
Department of Molecular Genetics, Weizmann Institute of Science 76100 Rehovot, Israel
Bioinformatics 21:650-9. 2005..Genes are often characterized dichotomously as either housekeeping or single-tissue specific. We conjectured that crucial functional information resides in genes with midrange profiles of expression...
- The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticlesMinjung Cho
Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
Toxicol Lett 189:177-83. 2009..and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo...
- Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studiesNikolai Khlebtsov
Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr Entuziastov, Saratov 410049, Russian Federation
Chem Soc Rev 40:1647-71. 2011....
- Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzeneRonald J Jandacek
Department of Pathology and Laboratory Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45237, USA
Am J Physiol Gastrointest Liver Physiol 288:G292-9. 2005..Distribution of 14C into the brain resulting from the restricted diet was reduced by 50% by dietary olestra...
- The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehogD M Stone
Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
Nature 384:129-34. 1996..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
- Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory studyJimena Cazenave
Universidad Nacional de Cordoba, Facultad de Ciencias Exactas, Fisicas y Naturales, Cátedra Diversidad Animal II, Velez Sarsfield 299, 5000 Cordoba, Argentina
Aquat Toxicol 75:178-90. 2005..These findings also raise questions on the probable neurotoxicity of microcystins...
- Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug deliveryJianjun Cheng
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Biomaterials 28:869-76. 2007..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
- Biodistribution and toxicity of intravenously administered silica nanoparticles in miceGuangping Xie
Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Arch Toxicol 84:183-90. 2010..Here we investigated the long-term (30 days) quantitative tissue distribution, and subcellular distribution, as well as potential toxicity of two sizes of intravenously administered ..
- Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injectionP Laverman
Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Pharmacol Exp Ther 298:607-12. 2001..Therefore, these findings may have a considerable impact on the clinical application of liposomal formulations that are administered repeatedly...
- Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1Jonathan D Turner
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
J Mol Endocrinol 35:283-92. 2005....
- Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticlesWan Seob Cho
Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung ku, Seoul 122 704, Republic of Korea
Toxicol Appl Pharmacol 236:16-24. 2009..These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications...
- Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organsWolfgang G Kreyling
Helmholtz Center Munich, Neuherberg Munich, Germany
Inhal Toxicol 21:55-60. 2009..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
- Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarctionWon Jun Kang
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
J Nucl Med 47:1295-301. 2006..The aim of this study was to investigate the homing and tissue distribution of intracoronary injected peripheral hematopoietic stem cells labeled with 18F-FDG.
- Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administrationCheng Feng Luo
The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510260, China
Int J Pharm 410:138-44. 2011..The objective of this study was to investigate the pharmacokinetics, tissue distribution and relative bioavailability of puerarin in rats after a single dose intragastric administration of ..
- PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacyYuta Yoshizawa
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
Int J Pharm 412:132-41. 2011..These results suggest that PEG liposome would serve as a potent PTX delivery vehicle for the future cancer chemotherapy...
- Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticlesJ F Hillyer
Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 1656 Linden Drive, Madison, Wisconsin 53706, USA
J Pharm Sci 90:1927-36. 2001..To our knowledge this is the first report, at the ultrastructural level, of gastrointestinal uptake of particulates by persorption through holes created by extruding enterocytes...
- Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensionsLei Gao
Department of Pharmaceutics, College of Pharmacy, Shandong University, 44 Wenhua Xilu, Jinan 250012, China
Int J Pharm 355:321-7. 2008The purpose of the present study was to investigate the effects of particle size on the pharmacokinetics and tissue distribution of oridonin nanosuspensions after intravenous administration...
- A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activationB S Kwon
Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 272:14272-6. 1997..A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation...
- The kinetics of the tissue distribution of silver nanoparticles of different sizesD P K Lankveld
Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
Biomaterials 31:8350-61. 2010Blood kinetics and tissue distribution of 20, 80 and 110 nm silver nanoparticles were investigated in rats up to 16 days after intravenous administration once daily for 5 consecutive days...
- Anti-inflammatory properties of cerium oxide nanoparticlesSuzanne M Hirst
Center for Molecular Medicine and Infectious Diseases CMMID, 1410 Prices Fork Blacksburg, VA 24060, USA
Small 5:2848-56. 2009..Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation...
- P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugsA H Schinkel
The Netherlands Cancer Institute, Division of Molecular Biology, 1066 CX Amsterdam, The Netherlands
J Clin Invest 97:2517-24. 1996..b>Tissue distribution studies demonstrated that the relative brain penetration of radiolabeled ondansetron and loperamide (and ..
- Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursorsY Coulouarn
European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, Mont Saint Aignan, France
FEBS Lett 457:28-32. 1999..In situ hybridization histochemistry showed that the prepro-UII gene is predominantly expressed in motoneurons of the brainstem and spinal cord, suggesting that UII may play a role in the control of neuromuscular functions...
- Axon tracts correlate with netrin-1a expression in the zebrafish embryoJ D Lauderdale
Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
Mol Cell Neurosci 9:293-313. 1997..These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways...
- Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distributionHenrik Nordman
Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
Biochem J 364:191-200. 2002..Following ion-exchange HPLC, both MUC5AC and MUC6 appeared as several distinct populations, probably corresponding to 'glycoforms' of the mucins, the most highly charged of which were found in the gland tissue...
- Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposomeNoriyuki Maeda
Department of Medical Biochemistry and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
J Control Release 100:41-52. 2004..The present results demonstrate the beneficial usage of APRPG-PEG for the active-targeting of drug carriers to angiogenic site in the novel modality of tumor treatment, namely ANET...
- Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumoursAndreas Helisch
Department of Nuclear Medicine, University of Mainz, Mainz, Germany
Eur J Nucl Med Mol Imaging 31:1386-92. 2004....
- A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructsJasmine P Davda
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
Int Immunopharmacol 8:401-13. 2008..The model gave satisfactory predictions of CC49 disposition and tumor uptake in man...
- 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluationRaffaella Rossin
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 46:1210-8. 2005..The purpose of this study was to evaluate 64Cu-radiolabeled folate-conjugated shell cross-linked nanoparticles (SCKs) as candidate agents to shuttle radionuclides and drugs into tumors overexpressing the folate receptor (FR)...
- Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle sizeGaneshchandra Sonavane
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan
Colloids Surf B Biointerfaces 66:274-80. 2008..The results revealed that tissue distribution of gold nanoparticles is size-dependent with the smallest 15 nm nanoparticles showing the most widespread ..
- Rapid translocation of nanoparticles from the lung airspaces to the bodyHak Soo Choi
Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Nat Biotechnol 28:1300-3. 2010..We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis...
- Identification and tissue distribution of odorant binding protein genes in the lucerne plant bug Adelphocoris lineolatus (Goeze)Shao Hua Gu
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Insect Biochem Mol Biol 41:254-63. 2011..The possible physiological functions of these OBPs are discussed...
- Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexesC Andrew Boswell
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Med Chem 47:1465-74. 2004..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
- Tissue distribution of quercetin in rats and pigsVincent C J de Boer
RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
J Nutr 135:1718-25. 2005..To assess the long-term tissue distribution of quercetin, 2 groups of rats were given a 0...
- Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labelingAlexandra Aicher
Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
Circulation 107:2134-9. 2003..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals...
- Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in ratsSuresh K Balasubramanian
Division of Environmental Science and Engineering, Department of Anatomy, National University of Singapore, Singapore
Biomaterials 31:2034-42. 2010..These results demonstrate that significant biodistribution of Au occurs in the body over 2 months after a single i.v. injection of AuNPs, accompanied by gene expression changes in target organs...
- Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugatesPaolo Caliceti
Department of Pharmaceutical Sciences, University of Padua, Via F Marzolo 5, 35131 Padova, Italy
Adv Drug Deliv Rev 55:1261-77. 2003..The examples reported in this review show that general considerations could be useful in developing a target product, although significant deviations from the expected results can not be excluded...
- Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levelsErik S Mittra
Molecular Imaging Program, Department of Radiology, Division of Nuclear Medicine, Stanford Hospital and Clinics, 300 Pasteur Dr, Room H2200, Stanford, CA 94305 5281, USA
Radiology 260:182-91. 2011....
- Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouseJ F Couse
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 138:4613-21. 1997..of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types...
- Comparative study of the in vitro and in vivo characteristics of cationic and neutral liposomesWei Zhao
Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
Int J Nanomedicine 6:3087-98. 2011..Caution should be exercised when chemotherapeutic drugs are loaded into CLP for tumor therapy...
- Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid compositionWilhelm Palm
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
PLoS Genet 8:e1002828. 2012..These studies define major routes of interorgan lipid transport in Drosophila and uncover surprising tissue-specific differences in lipoprotein lipid utilization...
- Brain- and heart-type fatty acid-binding proteins in the brain: tissue distribution and clinical utilityMaurice M A L Pelsers
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
Clin Chem 50:1568-75. 2004..We investigated the tissue distribution of brain- and heart-type fatty acid-binding proteins (B-FABP and H-FABP) in segments of the human brain and ..
- Monitoring of magnetic targeting to tumor vasculature through MRI and biodistributionEvin Gultepe
Northeastern University, Boston, MA, USA
Nanomedicine (Lond) 5:1173-82. 2010....
- Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical settingJoost Westerhout
Department of Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
J Pharm Sci 100:3577-93. 2011..g., inhibition of an efflux transporter or induction of pathological state). With the use of advanced mathematical modeling procedures, we may dissect contributions of individual mechanisms in animals as links to the human situation...
- Analysis of cause of failure of new targeting peptide in PEGylated liposome: molecular modeling as rational design tool for nanomedicineJulia Lehtinen
Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
Eur J Pharm Sci 46:121-30. 2012..We know of no means to investigate this experimentally with atomic level resolution, thus our use of computational methods to investigate this can be seen as a new tool for rational design in nanomedicine...
- Effects of charge on antibody tissue distribution and pharmacokineticsC Andrew Boswell
Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Research and Early Development, South San Francisco, California 94080, USA
Bioconjug Chem 21:2153-63. 2010..I) shifts in isoelectric point of approximately one pI unit or more can produce measurable changes in tissue distribution and kinetics, (II) increases in net positive charge generally result in increased tissue retention and ..
- Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor modelHuan Meng
Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, United States
ACS Nano 5:4131-44. 2011..Further endowment of this multifunctional drug delivery platform with targeting ligands and nanovalves may further enhance cell-specific targeting and on-demand release...
- Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzymeA L Albiston
Baker Institute of Medical Research, Prahran, Melbourne, Australia
Mol Cell Endocrinol 105:R11-7. 1994..These data suggest that 11 beta HSD2 plays an important role in modulating mineralocorticoid and glucocorticoid receptor occupancy by glucocorticoids...
- Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in ratsHolger Fuchs
Boehringer Ingelheim Pharma GmbH and Co KG, Department of Drug Metabolism and Pharmacokinetics, Birkendorfer Str 65, 88397 Biberach Riss, Germany
Biopharm Drug Dispos 30:229-40. 2009..In order to test these hypotheses, the tissue distribution of BI 1356 was determined in wild-type and DPP-4 deficient rats at different dose levels by means of whole ..
- Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imagingK H Lee
Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Nucl Med Commun 24:1003-9. 2003..Thus, substrate availability should be considered as a potential limiting factor for photon emission efficiency in certain organs when attempting quantitative interpretation of optical luc gene imaging...
- Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley ratsSiva K Nalabotu
Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C Edwards School of Medicine, Huntington, WV 25755 1090, USA
Int J Nanomedicine 6:2327-35. 2011..Herein, we examine if a single intratracheal instillation of CeO(2) nanoparticles is associated with systemic toxicity in male Sprague-Dawley rats...
- Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumorsHanwen Zhang
Division of Radiological Chemistry, Institute of Nuclear Medicine, Department of Radiology, University Hospital, Basel
Cancer Res 64:6707-15. 2004....
- Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticlesK Avgoustakis
Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion 26500, Patras, Greece
Int J Pharm 259:115-27. 2003..This may be associated with the effects of the mPEG/PLGA ratio on the density of PEG on the surface of the nanoparticles and on the size of the nanoparticles...
- Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersionHaiping Hao
Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China
Planta Med 72:1311-7. 2006This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza...
- Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administrationElsa M Janle
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
J Med Food 13:926-33. 2010..To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell ..
- Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapyBrandon Kwong
Department of Biological Engineering, Massachusetts Institute of Technology, 77 Mass Ave, Cambridge, MA 02139, USA
Biomaterials 32:5134-47. 2011..The development of a delivery strategy capable of inducing robust anti-tumor responses concurrent with minimal systemic side effects is crucial for the continued progress of potent immunotherapies toward widespread clinical translation...
- Whole-body physiologically based pharmacokinetic modelsIvan Nestorov
ZymoGenetics Inc, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA
Expert Opin Drug Metab Toxicol 3:235-49. 2007....
- In vivo PET imaging and biodistribution of radiolabeled gold nanoshells in rats with tumor xenograftsHuan Xie
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburn St, Houston, TX 77004, United States
Int J Pharm 395:324-30. 2010..Overall, PET images with (64)Cu had good resolution and therefore can be further applied to guide photothermal treatment of cancer...
- Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional networkAngie L Bookout
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, 75390, USA
Cell 126:789-99. 2006..These data reveal a hierarchical transcriptional circuitry that extends beyond individual tissues to form a meganetwork governing physiology on an organismal scale...
- A Pex7 hypomorphic mouse model for plasmalogen deficiency affecting the lens and skeletonNancy Braverman
Department of Human Genetics and Pediatrics, Montreal Children s Hospital Research Institute, McGill University, Montreal, QC, Canada
Mol Genet Metab 99:408-16. 2010..The role of plasmalogens in the normal function of these tissues at various ages can now be studied and additional therapeutic interventions tested in this model...
- Evaluation of iron oxide nanoparticle biocompatibilityAmel Hanini
Interface Traitement, Organisation et Dynamique des Systemes, Universite Paris 7, Paris, France
Int J Nanomedicine 6:787-94. 2011..In conclusion, γ-Fe(2)O(3) could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications...
- Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout miceAmit Garg
Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, Buffalo, NY 14260, USA
J Pharmacokinet Pharmacodyn 34:687-709. 2007..functions to protect immune gamma globulin (IgG) from elimination, the influence of FcRn on the tissue distribution of IgG has not been quantified...
- Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbitsV D Awasthi
Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Int J Pharm 253:121-32. 2003..Beyond this range, the stealth property of PEG-liposomes is significantly compromised and the distribution is characterized by high RES accumulation...
- Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in ratsEric Fabian
BASF Product Safety, BASF Aktiengesellschaft, Ludwigshafen, Germany
Arch Toxicol 82:151-7. 2008The tissue distribution and toxicity of intravenously administered nanoparticles of titanium dioxide (TiO2) (>10 wt...
- SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methodsAlie Schuitemaker
Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
Neuroimage 35:1473-9. 2007..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
- Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum miceJ Dowling
Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, Chicago, Illinois 60637, USA
Dev Biol 187:131-42. 1997..Collectively, our findings suggest a mechanism for the BPAG1 null phenotype and indicate that different neurons respond differently to the absence of BPAG1-n, a cytoskeletal linker protein...
- Cloning and functional expression of a human liver organic cation transporterL Zhang
Department of Biopharmaceutical Sciences, University of California San Francisco 94143, USA
Mol Pharmacol 51:913-21. 1997..In comparison to rOCT1, hOCT1 exhibits notable differences in its kinetic characteristics and tissue distribution. The functional expression of hOCT1 will provide a powerful tool for elucidation of the mechanisms of ..
- Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markersA F Ruchon
Departement de Biochimie, Universite de Montreal, Canada
J Bone Miner Res 15:1440-50. 2000..We characterized the developmental expression and tissue distribution of Phex protein, using a monoclonal antibody against human PHEX, examined the effect of the Hyp mutation on ..
- High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer modelT M Behr
Department of Nuclear Medicine, Georg August University, Gottingen, Germany
Cancer Res 59:2635-43. 1999..Due to its short physical half-life, 213Bi appears to be especially suitable for use in conjunction with fast-clearing fragments...
- Inhibition of cancer growth by resveratrol is related to its low bioavailabilityMiguel Asensi
Departamento de Fisiologia, Universidad de Valencia, Valencia, Spain
Free Radic Biol Med 33:387-98. 2002....
- Cell-type-specific signatures of microRNAs on target mRNA expressionPranidhi Sood
Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
Proc Natl Acad Sci U S A 103:2746-51. 2006..We show that this tool can identify functionally important 3' UTR motifs without cross-species comparison...
- Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse modelMarcel L Janssen
Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
Cancer Res 62:6146-51. 2002..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
- Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivativesMartin Behe
Department of Nuclear Medicine, Philipps University of Marburg, Baldingerstrasse, 35043, Marburg, Germany
Eur J Nucl Med Mol Imaging 30:1140-6. 2003..DTPA- dGlu(1)-minigastrin is preferred to "monofunctional" DTPA-Leu(1)-minigastrin for diagnostic application with (111)In for the in vivo detection of CCK-B receptor-expressing tissues...
- PET of EGFR antibody distribution in head and neck squamous cell carcinoma modelsGang Niu
Molecular Imaging Program at Stanford MIPS, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305 5484, USA
J Nucl Med 50:1116-23. 2009....
- Modelling and PBPK simulation in drug discoveryHannah M Jones
Pfizer Global R and D, Department of Pharmacokinetics, Dynamics and Metabolism, IPC 654, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
AAPS J 11:155-66. 2009..Specific reference is made to its utility (1) at the lead development stage for the prioritization of compounds for animal PK studies and (2) at the clinical candidate selection and "first in human" stages for the prediction of human PK...
- Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapyVania Kenanova
Division of Molecular Biology, Beckman Research Institute of the City of Hope, Department of Radioimmunotherapy, Duarte, CA, USA
Cancer Res 67:718-26. 2007..Finally, the 125I/111In biodistribution data allowed for dose estimations, which suggest the 131I-labeled scFv-Fc H310A/H435Q as a promising candidate for radioimmunotherapy...
- A toxicokinetic model for predicting the tissue distribution and elimination of organic and inorganic mercury following exposure to methyl mercury in animals and humans. II. Application and validation of the model in humansG Carrier
Chair in Toxicological Risk Assessment for Human Health, Department of Environmental and Occupational Health, Faculty of Medicine, Universite de Montreal, Main Station, Montreal, Quebec, H3C 3J7, Canada
Toxicol Appl Pharmacol 171:50-60. 2001..Thus, accessible measurements on these matrices allow inferences of past, present, and future burdens. This could prove to be a useful tool in assessing the health risks associated with various circumstances of methyl mercury exposure...
- Antisense therapeuticsS Agrawal
Hybridon Inc, Cambridge, MA 02139, USA
Curr Opin Chem Biol 2:519-28. 1998..Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously...
- Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscleA Musaro
Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts, USA
Nat Genet 27:195-200. 2001..The preservation of muscle architecture and age-independent regenerative capacity through localized mIgf-1 transgene expression suggests clinical strategies for the treatment of age or disease-related muscle frailty...
- Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activityWei Wu
Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, People s Republic of China
ACS Nano 3:2740-50. 2009....
- In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancerEmilia S Olson
Department of Pharmacology, La Jolla, CA 92093 0647, USA
Integr Biol (Camb) 1:382-93. 2009..Our results validate an approach that should generally deliver imaging agents and chemotherapeutics to sites of invasion, tumor-promoting inflammation, and metastasis...
- Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14 C-bortezomibAlex Hemeryck
Global Preclinical Development, Johnson and Johnson Pharmaceutical Research and Development, A Division of Janssen Pharmaceutica N V, Beerse, Belgium
Cancer Chemother Pharmacol 60:777-87. 2007..The body distribution of total radioactivity (TR) and bortezomib was investigated in male Sprague-Dawley rats after single and repeated i.v. (bolus) administration with (14)C-labelled bortezomib (VELCADE) (0.2 mg/kg; 0.28 MBq./kg)...
- Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neuronsMarjo Piltonen
Division of Pharmacology and Toxicology, Faculty of Pharmacy, P O Box 56, FIN 00014 University of Helsinki, Finland
Exp Neurol 219:499-506. 2009..The results imply that GDNF binding to HSs is needed for the optimum neuroprotective effect...
- Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface chargeY Yamamoto
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
J Control Release 77:27-38. 2001....
- Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugsTheodosia Maina
Institute of Radioisotopes Radiodiagnostic Products, National Center for Scientific Research Demokritos, 152 10 Ag Paraskevi Arrikis, Athens, Greece
J Nucl Med 46:823-30. 2005....
- Peptide Derivatives to treat Urinary Tract InfectionsLaszlo Otvos; Fiscal Year: 2003..for new antimicrobial compounds to treat human urinary tract infections (UTI) and the generally observable tissue distribution and renal clearance of peptidic drugs suggest that if appropriately developed, pyrrhocoricin derivatives ..
- Functions of the Human OST-alpha and OST-beta ProteinsNazzareno Ballatori; Fiscal Year: 2010..Our studies to date of the transporter's substrate specificity, transport mechanism, tissue distribution, subcellular localization, transcriptional regulation, as well as the phenotype of our recently ..
- Creation and validation of a lux-positive Candida strainYue Fu; Fiscal Year: 2007..However, a crucial limitation of murine models of candidiasis is the need to sacrifice animals to determine tissue distribution of the fungus...
- PURIFICATION AND CHARACTERIZATION OF ADENOSINE RECEPTORSJoel Linden; Fiscal Year: 1993..We will clone putative subtypes of A1 and A2 receptors and will determine the tissue distribution of mRNA's by in situ hybridization...
- Phytoestrogens as an alternative treatment for MSLarry Sherman; Fiscal Year: 2006..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
- Phytoestrogens as an alternative treatment for MSBruce Bebo; Fiscal Year: 2005..Because of the distinct tissue distribution of these two receptors, phytoestrogens have potent estrogen-agonist activity in bone and cardiovascular ..
- Fluorophore-Conjugated Antibodies for Imaging and Resection of GI TumorsMeng Yang; Fiscal Year: 2010..Toxicity, dosing, and tissue distribution studies will be performed for fluorophore-conjugated monoclonal antibodies...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2009..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
- Mixture Modeling: Pesticide Drug InteractionsCharles Timchalk; Fiscal Year: 2007..and pharmacodynamic responses are altered when chemical mixtures modify absorption rates, metabolism, tissue distribution, clearance and pharmacological action...
- Nutritional Biochemistry of beta-Carotene DioxygenaseA Andersson; Fiscal Year: 2005..Our initial goal will be a detailed analysis of tissue distribution and cell type-specific expression of the BCDO enzyme...
- COMPLEX CARBOHYDRATES OF NERVOUS TISSUERICHARD MARGOLIS; Fiscal Year: 2001....
- DEVELOPMENT OF AN ORAL DRUG FOR SMALLPOX TREATMENTGeorge Painter; Fiscal Year: 2007..In addition, tissue distribution experiments indicate that the lipid-CDV conjugates are not deposited in the kidney, suggesting the ..
- Biological roles of galectinsGERARDO RAUL VASTA; Fiscal Year: 2010..tandem-repeat, and chimeric tandem-repeat galectins, and characterized their developmental expression and tissue distribution. We performed preliminary functional analyses: knockdown embryos for proto type galectins exhibit disrupted ..
- MOLECULAR BIOLOGY OF THE MARFAN SYNDROMEHarry Dietz; Fiscal Year: 1999..Variability in the age of onset, tissue distribution, and severity of manifestations is common both in and among families...
- Molecular Determinants of Pyrethroid NeurotoxicityDAVID SODERLUND; Fiscal Year: 2009..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
- Molecular Determinants of Pyrethroid NeurotoxicityDAVID SODERLUND; Fiscal Year: 2007..Sodium channels in mammalian tissues exist as multiple isoforms that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family...
- CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATIONRICHARD ECKERT; Fiscal Year: 2004..i) ability to act as a TG substrates and the effects of TG modification on function, (ii) subcellular and tissue distribution and the effects of physiological agents in this distribution, (iii) interaction with target proteins, and (..
- Role of CIC-3 channels in regulation of cell volume and shape in neutrophilsJessica Moreland; Fiscal Year: 2007..CIC-3, a voltage sensitive anion channel with widespread tissue distribution is expressed in PMN. Clcn3-/- mice were generated to study the role of this gene in hypertension...
- Endosymbiont, Arbovirus & Mosquito Interactions and the Disease ControlZhiyong Xi; Fiscal Year: 2010..Given the large overlap in tissue distribution and intracellular localization of Wolbachia and dengue virus in mosquitoes, it is imperative that we ..
- ENDOGENOUS OPIOID PEPTIDE ACTION IN THE HIPPOCAMPUSCharles Chavkin; Fiscal Year: 1993..Substantial progress has been made in defining the molecular forms, tissue distribution, specific receptors, and pharmacological actions of the endogenous opioid peptides, yet little is known ..
- Body Composition & REE Responses to Bariatric SurgeriesDympna Gallagher; Fiscal Year: 2007..Using MRI, we will describe body composition changes at the tissue and organ level and adipose tissue distribution allowing us to address questions of biological and clinical importance including the body composition ..
- Origins of Diversity at Human Classical MHC Class I GenesPETER R PARHAM; Fiscal Year: 2010..and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, and a peptide- binding specificity like HLA-A*02...
- Development of biomimetic oligomers as anti-coagulant antagonistsRichard Scott; Fiscal Year: 2007..have many advantages over peptides: relatively smaller size which increases stability and enhances tissue distribution, ease of synthesis, resistance to proteolytic degradation, and suitability for medicinal chemistry ..