renin angiotensin system

Summary

Summary: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.

Top Publications

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
  2. ncbi Renin-angiotensin system revisited
    F Fyhrquist
    Minerva Institute for Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Intern Med 264:224-36. 2008
  3. ncbi Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system
    Julie L Lavoie
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 144:2179-83. 2003
  4. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
  5. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
  6. ncbi Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Klybeckstrasse 220, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 308:698-705. 2003
  7. pmc The renin angiotensin system and the metabolic syndrome
    Annette D de Kloet
    Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
    Physiol Behav 100:525-34. 2010
  8. ncbi Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat
    Christos Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Diabetes 53:989-97. 2004
  9. ncbi Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?
    Mark C Chappell
    Hypertension and Vascular Disease Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27015, USA
    Hypertension 50:596-9. 2007
  10. ncbi Drugs targeting the renin-angiotensin-aldosterone system
    Mohammad Amin Zaman
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Rev Drug Discov 1:621-36. 2002

Detail Information

Publications316 found, 100 shown here

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..The full text of this article is available at http://www. circresaha.org...
  2. ncbi Renin-angiotensin system revisited
    F Fyhrquist
    Minerva Institute for Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Intern Med 264:224-36. 2008
    ..Great expectations are now generated by the introduction of renin inhibitors. Indeed, RAS regulates much more and diverse physiological functions than previously believed...
  3. ncbi Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system
    Julie L Lavoie
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 144:2179-83. 2003
    ..Thus, this minireview will discuss recent advances in understanding the relationship between endocrine and paracrine (tissue) RAS using transgenic models...
  4. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  5. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
    ..Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, remains uncertain...
  6. ncbi Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Klybeckstrasse 220, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 308:698-705. 2003
    ..Aliskiren represents the first in a novel class of renin inhibitors with the potential for treatment of hypertension and related cardiovascular diseases...
  7. pmc The renin angiotensin system and the metabolic syndrome
    Annette D de Kloet
    Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
    Physiol Behav 100:525-34. 2010
    The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic ..
  8. ncbi Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat
    Christos Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Diabetes 53:989-97. 2004
    ..These findings provide a possible mechanism for the reduced incidence of new-onset diabetes that has been observed in clinical trials of RAS blockade...
  9. ncbi Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?
    Mark C Chappell
    Hypertension and Vascular Disease Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27015, USA
    Hypertension 50:596-9. 2007
  10. ncbi Drugs targeting the renin-angiotensin-aldosterone system
    Mohammad Amin Zaman
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Rev Drug Discov 1:621-36. 2002
    ....
  11. ncbi Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
    Vivek P Singh
    Cardiovascular Research Institute, Texas A and M HSC, Temple, TX 76504, USA
    Am J Physiol Heart Circ Physiol 294:H1675-84. 2008
    ....
  12. ncbi Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes
    C Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Wynn Domain, Baker Heart Research Institute, Melbourne, Vic, Australia
    Int J Biochem Cell Biol 38:737-51. 2006
    ..It is hoped that these studies will demonstrate the true potential of the blockade of the renin-angiotensin system for the prevention of diabetes...
  13. ncbi The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice
    J C B Ferreira
    School of Physical Education and Sport, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Regul Integr Comp Physiol 294:R26-32. 2008
    Sympathetic hyperactivity (SH) and renin angiotensin system (RAS) activation are commonly associated with heart failure (HF), even though the relative contribution of these factors to the cardiac derangement is less understood...
  14. ncbi Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
    ..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
  15. ncbi Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)
    Lucia Maria Procopciuc
    Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 14 Padis Street, Cluj Napoca, Romania
    Eur J Intern Med 21:414-8. 2010
    ..The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS)...
  16. ncbi Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
    ..The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components...
  17. ncbi The role of the central renin-angiotensin system in Parkinson's disease
    Birgit Mertens
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Renin Angiotensin Aldosterone Syst 11:49-56. 2010
    ..They include inhibition of the angiotensin-converting enzyme, blockade of the angiotensin II type 1 receptor and stimulation of the angiotensin II type 2 receptor...
  18. ncbi The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease
    Ursula C Brewster
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Med 116:263-72. 2004
    ....
  19. pmc Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Pathol 163:1261-73. 2003
    ....
  20. ncbi Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    ..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
  21. ncbi The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition
    Steven A Atlas
    James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    J Manag Care Pharm 13:9-20. 2007
    ..Dysregulation of the RAAS plays an important role in the pathogenesis of cardiovascular and renal disorders...
  22. ncbi Improvement of insulin sensitivity by antagonism of the renin-angiotensin system
    Erik J Henriksen
    Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007
    ..Collectively, these findings support targeting the RAS in the design of interventions to improve metabolic and cardiovascular function in conditions of insulin resistance associated with prediabetes and type 2 diabetes...
  23. ncbi Role of the renin-angiotensin system in vascular inflammation
    Chiara Marchesi
    Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Trends Pharmacol Sci 29:367-74. 2008
    ..The present review addresses recent findings regarding the pathophysiology of vascular inflammation in hypertension, focusing specifically on the role of Ang II...
  24. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..These results are compatible with the concept of multilocus and multi-gene effects in complex diseases that would be missed with conventional approaches...
  25. ncbi Angiotensin-(1-7) and the renin-angiotensin system
    Robson A S Santos
    Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Curr Opin Nephrol Hypertens 16:122-8. 2007
    ..In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system...
  26. ncbi Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 289:H2281-90. 2005
    ..II to angiotensin (1-7), this has changed our overall perspective about the classical view of the renin angiotensin system in the regulation of hypertension and heart and renal function, because it represents the first example ..
  27. ncbi Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells
    William B Strawn
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Haematol 126:120-6. 2004
    ..The presence of Ang II receptors in both haematopoietic-lineage BMC and MSC, and the de novo synthesis of Ang II by MSC suggest a potential autocrine-paracrine mechanism for local RAS-mediated regulation of haematopoiesis...
  28. ncbi Renin-angiotensin gene polymorphism in children with uremia and essential hypertension
    Ferenc Papp
    Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6720 Szeged, Hungary
    Pediatr Nephrol 18:150-4. 2003
    ..Furthermore, there was a significant increase in MT genotype frequency of ANG M235T polymorphism in pediatric ESRD and JEHT. The role of AT1R gene polymorphism needs further investigation...
  29. ncbi Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone
    Alison Harte
    Unit for Diabetes and Metabolism, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom
    Circulation 111:1954-61. 2005
    ..We therefore examined the effect of rosiglitazone (RSG) on the insulin-mediated upregulation of the RAS...
  30. ncbi Diabetes, hypertension, and cardiovascular disease: an update
    J R Sowers
    SUNY Downstate Medical Center and VAMC, Brooklyn, NY, USA
    Hypertension 37:1053-9. 2001
    ..This update also examines the role of the renin-angiotensin system in the increased risk for CVD in diabetic patients and the impact of interrupting this system on the development of clinical diabetes as well as CVD...
  31. pmc Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
    Johannes Stegbauer
    Department of Nephrology, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 106:14942-7. 2009
    Angiotensin II is the principle effector molecule of the renin angiotensin system (RAS)...
  32. pmc Regulation of T-cell function by endogenously produced angiotensin II
    Nyssa E Hoch
    Division of Cardiology, the Lowance Center of Human Immunology, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 296:R208-16. 2009
    ..These findings contribute to our understanding of how ANG II and T cells enhance inflammation in cardiovascular disease...
  33. ncbi Renin angiotensin system blockade in kidney transplantation: a systematic review of the evidence
    S Hiremath
    Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Am J Transplant 7:2350-60. 2007
    ....
  34. ncbi Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
    ..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
  35. ncbi Impact of hyperglycemia on the renin angiotensin system in early human type 1 diabetes mellitus
    J A Miller
    Department of Medicine, University of Toronto, Ontario, Canada
    J Am Soc Nephrol 10:1778-85. 1999
    ..by testing the hypothesis that mild to moderate hyperglycemia can affect renal function by increasing renin angiotensin system (RAS) activity in diabetic humans...
  36. ncbi From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension
    Ernesto L Schiffrin
    Canadian Institutes of Health Research Multidisciplinary Research Group on Hypertension and Hypertension Clinic, Clinical Research Institute of Montreal, Quebec, Canada H2W 1R7
    Am J Physiol Heart Circ Physiol 287:H435-46. 2004
  37. ncbi Glomerular permeability defect in hypertension is dependent on renin angiotensin system activation
    Riccardo Candido
    Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy
    Am J Hypertens 18:844-50. 2005
    ..The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS)...
  38. pmc Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring
    Daniela Grigore
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 293:R804-11. 2007
    ..We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by ..
  39. ncbi It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system
    Michael Bader
    Circ Res 90:8-10. 2002
  40. ncbi Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    J Mol Cell Cardiol 34:1443-53. 2002
    ..The central focus of this review is on recent studies suggesting that modulation or activation of JAK-STAT signaling by ANG II has pathological consequences for heart function...
  41. ncbi Circulating renin Angiotensin system in childhood chronic renal failure: marked increase of Angiotensin-(1-7) in end-stage renal disease
    Ana C Simoes e Silva
    Department of Pediatrics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
    Pediatr Res 60:734-9. 2006
    ..Our data showed different circulating RAS profiles between hypertensive and in normotensive CRF subjects. Marked changes in plasma Ang-(1-7) were associated with the presence of hypertension and progression of kidney dysfunction...
  42. ncbi Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    ....
  43. ncbi The role of angiotensin II in cognition and behaviour
    Paul R Gard
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    Eur J Pharmacol 438:1-14. 2002
    ..The role of the brain renin-angiotensin system in human psychopathology remains to be fully explored...
  44. ncbi Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation
    Mollie Jurewicz
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 18:1093-102. 2007
    ..Because their chemotaxis is enhanced by AngII, this creates a potential inflammatory amplification system...
  45. ncbi Update on tissue renin-angiotensin systems
    Michael Bader
    Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
    J Mol Med (Berl) 86:615-21. 2008
    ..This review summarizes the recent findings on the importance of tissue RAS in the most relevant cardiovascular organs...
  46. ncbi Hypertensive myocardial fibrosis
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Via F Sforza 35, 20122 Milano, Italy
    Nephrol Dial Transplant 21:20-3. 2006
  47. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  48. ncbi Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats
    Manuel Portero-Otin
    Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLLEIDA PCiTAL Parc Científic Agroalimentari de Lleida, 25008 Lleida, Spain
    Biochem Biophys Res Commun 368:528-35. 2008
    b>Renin angiotensin system (RAS) worsens diabetic nephropathy (DN) by increasing oxidative stress...
  49. pmc Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Hypertens 19:541-50. 2006
    ....
  50. ncbi Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  51. ncbi Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis
    Yoshiko Ihara
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 43:455-64. 2007
    ..Upregulation of the ligand-RAGE pathway via AT1R is an essential mechanism in diabetic atherosclerosis, implying that ARB might decrease diabetic atherogenesis by inhibiting ligand-RAGE signals...
  52. ncbi The renin angiotensin system in the regulation of angiogenesis
    S C Heffelfinger
    Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267 0529, USA
    Curr Pharm Des 13:1215-29. 2007
    ....
  53. pmc Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive rats
    Rodney J Bolterman
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 46:943-7. 2005
    ....
  54. ncbi Oral renin inhibitors
    Jan A Staessen
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Lancet 368:1449-56. 2006
    ..This Review summarises the development of oral renin inhibitors and their pharmacokinetic and pharmacodynamic properties, with a focus on aliskiren...
  55. ncbi Angiotensin-converting enzyme II in the heart and the kidney
    Ursula Danilczyk
    IMBA, Institute for Molecular Biotechnology, Austrian Academy of Sciences, D Bohr Gasse 7, A 1030 Vienna, Austria
    Circ Res 98:463-71. 2006
    ..The development of drugs that could activate ACE2 function would allow extending our treatment options in diabetic nephropathy, heart failure, or hypertension...
  56. ncbi Angiotensin receptor blockers may increase risk of myocardial infarction: unraveling the ARB-MI paradox
    Martin H Strauss
    Division of Cardiology, North York General Hospital, Toronto, Canada
    Circulation 114:838-54. 2006
  57. ncbi Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus
    Po Sing Leung
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Pancreas 30:293-8. 2005
    ..Blockade of the RAS could contribute to the development of novel therapeutic strategies in the prevention and treatment of patients with diabetes and in islet transplantation...
  58. ncbi Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
    Ramon Bataller
    Department of Medicine, Hospital Clinic, Institut d Investigacions Biomédiques August Pi y Sunyer, University of Brescia School of Medicine, Barcelona, Catalonia, Spain
    Gastroenterology 125:117-25. 2003
    ..The aim of this study was to investigate whether quiescent and activated human hepatic stellate cells contain the components of the renin-angiotensin system and synthesize angiotensin II...
  59. ncbi Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome
    Abhiram Prasad
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn, USA
    Circulation 110:1507-12. 2004
  60. ncbi Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system
    J F Reckelhoff
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 35:480-3. 2000
    ..However, the data further suggest that androgens promote the exacerbation of hypertension in male SHR via a mechanism involving the renin-angiotensin system...
  61. ncbi Origin of aldosterone in the rat heart
    Elise P Gomez-Sanchez
    Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, 1500 East Woodrow Wilson Drive 151, Jackson, Mississippi 39216, USA
    Endocrinology 145:4796-802. 2004
    ..In conclusion, we found that the level of aldosterone content in the healthy rat heart in vivo is significantly lower than that reported elsewhere and reflects plasma levels in intact rats...
  62. ncbi Sympathetic hyperactivity in chronic kidney disease: pathogenesis, clinical relevance, and treatment
    Jutta Neumann
    Department of Nephrology, University Medical Center Utrecht, The Netherlands
    Kidney Int 65:1568-76. 2004
    ....
  63. pmc Local adipose tissue renin-angiotensin system
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, Wethington Building, Room 521b, 900 South Limestone Street, University of Kentucky, Lexington, KY 40536 0200, USA
    Curr Hypertens Rep 10:93-8. 2008
    ..Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension...
  64. ncbi Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    Yuichiro Ishiyama
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Hypertension 43:970-6. 2004
    ..These results provide evidence for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotensin-(1-7)...
  65. ncbi The renin-angiotensin system and diabetic nephropathy
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Semin Nephrol 27:144-52. 2007
    ..We provide a general review of the RAS and its role in diabetic nephropathy...
  66. ncbi Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
    ..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
  67. pmc Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study
    C E Mogensen
    Department of Medicine, M, Kommunehospitalet, University Hospital, DK 8000 Aarhus C, Denmark
    BMJ 321:1440-4. 2000
    ..To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and type 2 diabetes...
  68. ncbi Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    ..01 for all compared to placebo). Thirst was significantly more common in patients treated with satavaptan compared to those treated with placebo, whereas the frequency of other adverse events was similar among groups...
  69. ncbi Myocardial infarction increases ACE2 expression in rat and humans
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
    Eur Heart J 26:369-75; discussion 322-4. 2005
    ..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
  70. ncbi Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments
    Aaron J Trask
    The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston Salem, North Carolina 27157, USA
    Cardiovasc Drug Rev 25:162-74. 2007
    ..This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum...
  71. ncbi Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)
    Iwona Kucharewicz
    Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland
    Hypertension 40:774-9. 2002
    ..Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)-evoked release of NO and prostacyclin...
  72. ncbi Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver
    Georgina Paizis
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Victoria, Australia
    Gastroenterology 123:1667-76. 2002
    Angiotensin II (ANG II) has profibrotic actions in the heart and kidney, whereas blockade of the renin angiotensin system (RAS) attenuates injury...
  73. ncbi Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:121-8. 2006
    ....
  74. ncbi Diabetes and retinal vascular disorders: role of the renin-angiotensin system
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan St, Parkville, Victoria, Australia
    Expert Rev Mol Med 6:1-18. 2004
    ..This review examines the role of the RAS in diabetic retinopathy and retinopathy of prematurity, and the potential of RAS blockade as a treatment strategy for these vision-threatening diseases...
  75. ncbi From mitochondria to disease: role of the renin-angiotensin system
    E M V De Cavanagh
    Laboratory of Experimental Nephrology, Institute for Cardiovascular Research, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    Am J Nephrol 27:545-53. 2007
    ..This review intends to present available information pointing to mitochondria as targets for therapeutic Ang-II blockade in human renal and CV disease...
  76. pmc Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuria
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
    Clin J Am Soc Nephrol 4:535-41. 2009
    ..Moreover, PTX3 has been suggested to represent a novel mortality risk factor, and elevated PTX3 levels have been shown to accompany increased albuminuria among patients with chronic kidney disease (CKD)...
  77. ncbi Obesity-associated hypertension: new insights into mechanisms
    Kamal Rahmouni
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hypertension 45:9-14. 2005
    ..These recent discoveries should lead to novel strategies for treatment of obesity and hypertension...
  78. ncbi Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research
    Carlos M Ferrario
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    J Renin Angiotensin Aldosterone Syst 7:3-14. 2006
    ..It is hoped that the next 100 years of research into the RAS will uncover hitherto unimaginable therapeutic opportunities...
  79. ncbi Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertension 42:76-81. 2003
    ..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
  80. ncbi Genetics of the human renin angiotensin system
    Xavier Jeunemaitre
    INSERM U772, College de France, 11 place Marcelin Berthelot, Paris, France
    J Mol Med (Berl) 86:637-41. 2008
    The genes coding for the renin angiotensin system have been extensively studied...
  81. ncbi Activation of a local renin angiotensin system in podocytes by glucose
    Raghu V Durvasula
    Univ of Washington School of Medicine, Division of Nephrology, Box 356521, Seattle, WA 98195, USA
    Am J Physiol Renal Physiol 294:F830-9. 2008
    ..Taken together, the resultant activation of a local renin angiotensin system by high glucose may promote progressive podocyte injury and loss in diabetic nephropathy.
  82. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
    ..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
  83. ncbi Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients
    J Redon
    Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
    Pharmacogenomics J 5:14-20. 2005
    ..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan...
  84. ncbi Aliskiren: renin inhibitor for hypertension management
    Judy W M Cheng
    Massachusetts College of Pharmacy and Health Sciences and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Ther 30:31-47. 2008
    ..Certain agents that modify the RAAS can control blood pressure and improve cardiovascular outcomes. Aliskiren is the first of a new class of antihypertensive agents known as renin inhibitors...
  85. pmc New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
    ..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
  86. ncbi Local renin-angiotensin systems: the unanswered questions
    A H Jan Danser
    Department of Pharmacology, Room EE1418b, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Int J Biochem Cell Biol 35:759-68. 2003
    ..with the local generation or effects of angiotensin II), and (5) to what degree do differences in tissue angiotensin generation underlie the association between cardiovascular diseases and renin-angiotensin system gene polymorphisms?..
  87. ncbi Effects of suppressing intrarenal angiotensinogen on renal transforming growth factor-beta1 expression in acute ureteral obstruction
    Gyu Tae Shin
    Department of Nephrology, Ajou University School of Medicine, Suwon, South Korea
    Kidney Int 67:897-908. 2005
    ..In addition, it has been proposed that the intrarenal renin-angiotensin system (RAS) is as important as the systemic RAS in kidney disease progression...
  88. pmc Activated intrarenal reactive oxygen species and renin angiotensin system in IgA nephropathy
    N Ohashi
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Minerva Urol Nefrol 61:55-66. 2009
    ..oxygen species (ROS) and those of intrarenal angiotensinogen (AGT) and angiotensin II (Ang II) markers of renin angiotensin system (RAS) in IgA nephropathy patients were significantly increased as compared to those of control subjects...
  89. ncbi Relationship between insulin resistance and the renin-angiotensin system: analysis for patients with essential and renovascular hypertension
    Tetsutaro Matayoshi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Clin Exp Hypertens 29:479-87. 2007
    ..However, there was no significant relationship between PRA and indices of insulin resistance and hyperinsulinemia in patients with RVHT. In conclusion, the systemic RAS may modulate insulin sensitivity in EHT patients...
  90. ncbi Novel aspects of the renal renin-angiotensin system: angiotensin-(1-7), ACE2 and blood pressure regulation
    Mark C Chappell
    The Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27015, USA
    Contrib Nephrol 143:77-89. 2004
  91. ncbi [Angiotensin converting enzyme 2 and its emerging role in the regulation of the renin angiotensin system]
    Maria Jose Soler
    Departamento de Nefrologia, Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Espana
    Med Clin (Barc) 131:230-6. 2008
    ..These results suggest that ACE2 might be a new therapeutic target within the RAS...
  92. ncbi Targeting the renin angiotensin system for remission/regression of chronic kidney disease
    Daniela Macconi
    Department of Biomedical Engineering, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Histol Histopathol 25:655-68. 2010
    ..This review describes experimental and clinical investigations documenting the advances achieved in the management of chronic kidney diseases by targeting angiotensin II...
  93. ncbi Effect of Valsartan on hospitalization: results from Val-HeFT
    Peter Carson
    Department of Veterans Affairs, Medical Center, Washington, DC 20422, USA
    J Card Fail 9:164-71. 2003
    ..5% versus placebo (P <.001). This article analyzes all-cause and investigator-assessed HF hospitalization in Val-HeFT overall and in subgroups defined by preexisting HF therapy...
  94. ncbi The renin angiotensin system as a risk factor for coronary artery disease
    J A Farmer
    Section of Cardiology, Ben Taub General Hospital and Baylor College of Medicine, 6550 Fannin, Houston, TX 77030, USA
    Curr Atheroscler Rep 3:117-24. 2001
    The renin angiotensin system was demonstrated to play a significant role in the genesis of hypertension and regulation of vascular tone over 100 years ago...
  95. ncbi HIV protease inhibitors activate the adipocyte renin angiotensin system
    Franck Boccara
    Faculte de Medecine Saint Antoine, INSERM, UMRS938, Paris, France
    Antivir Ther 15:363-75. 2010
    ..Whether hypertension and cardiovascular events could result from the adipocyte renin angiotensin system (RAS) overactivation has never been investigated.
  96. ncbi Mast cells activate the renin angiotensin system and contribute to migraine: a hypothesis
    Hisham Ba'albaki
    Heart Health Center Cardiology, and University of Alabama, Florence, AL 35631, USA
    Headache 48:1499-505. 2008
    ..The renin angiotensin system and its peptides are well represented in the mammalian central nervous system and can also promote ..
  97. ncbi Protective effect of long-term angiotensin II inhibition
    Nidia Basso
    Cardiovascular Pathophysiology Institute, Department of Pathology, School of Medicine, University of Buenos Aires, Argentina
    Am J Physiol Heart Circ Physiol 293:H1351-8. 2007
    ..An outstanding finding was the significant and similar prolongation of life span in both groups of treated animals compared with untreated control animals...
  98. ncbi Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats
    H Deniz
    Department of Internal Medicine, Marmara University Medical School, Istanbul, Turkey
    Transplant Proc 38:483-6. 2006
    ..In conclusion, the results of our study suggested that renin angiotensin inhibition down-regulates fibrogenic cytokine expression in rats displaying tacrolimus nephrotoxicity...
  99. pmc Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients
    Walkíria Wingester Vilas-Boas
    Laboratório de Hipertensão, Departamento de Fisiologia e Biofisica, ICB UFMG, Av Antonio Carlos, 6627, Belo Horizonte, MG, 31270 901, Brazil
    World J Gastroenterol 14:6824-30. 2008
    ....
  100. ncbi Role of renin angiotensin system in angiogenesis: it is still elusive
    Toshihiro Ichiki
    Arterioscler Thromb Vasc Biol 24:622-4. 2004
  101. ncbi Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study
    X Jeunemaitre
    Laboratoire de Biologie Moleculaire, Ilôt des Mariniers, Assistance Publique Hopitaux de Paris, Hopital Broussais, France
    Hum Genet 99:66-73. 1997
    ..19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis...

Research Grants73

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ....
  2. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ....
  3. Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..A better understanding of factors involved in insulin resistance should help in the development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
  4. Pharmacologic Interventions for Cardiovascular Disease in Obstructive Sleep Apnea
    Barbara J Morgan; Fiscal Year: 2013
    ..These interventions are novel, relevant, unobtrusive, relatively inexpensive, and could drasticallv change the treatment and possible prevention of cardiovascular disease in OSA. ..
  5. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..The goal of our research is to delineate the precise mechanisms of obesity-related cardiovascular disease and thus establish a rationale for therapeutic intervention. ..
  6. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..In addition to the proposed scientific research, this fellowship will support the applicant's participation in nanotechnology-based coursework and career development. ..
  7. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..The reduction in morbidity and mortality resulting from this would have a major impact on the lives of T1D patients as well as on society at large, significantly reducing the human and financial costs associated with this condition. ..
  8. Innate Immunity and Cardiovascular Function
    Gregory L Stahl; Fiscal Year: 2013
    ..Furthermore, these specific aims may subsequently lead to improved risk stratification, resource utilization, and the development of novel anti-complement therapies to protect against hyperglycemic cardiovascular complications. ..
  9. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The importance of the renin angiotensin system in cardiovascular disease has been proven by the positive clinical benefits associated with ACE inhibitors and angiotensin type 1 receptor (AT1R) ..
  10. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..We further hypothesize that implementation of caloric restriction and aerobic exercise is feasible and can improve the metabolic milieu. ..
  11. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Specific Aim 4 will investigate the role of ACE2/Ang (1-7)/Mas in counteracting ACE/Ang II/AT1 in the efficacy of EPCs transplantation for promoting repair after ischemic stroke. ..
  12. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..The reduction in morbidity and mortality resulting from this would have a major impact on the lives of T1D patients as well as on society at large, significantly reducing the human and financial costs associated with this condition. ..
  13. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ....
  14. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..to understand the mechanisms that contribute to the regulation of an important hormonal system - the renin angiotensin system in multiple tissues including the brain, heart, kidney and uterus/placenta...
  15. ROLE OF ENHANCERS REGULATING RENIN GENE EXPRESSION
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..These studies will link transcriptional signals regulating the renin gene with physiological endpoints controlling blood pressure and metabolism which may go awry in hypertension. I..
  16. Humoral factors in gender differences in blood pressure control
    Jane F Reckelhoff; Fiscal Year: 2013
    ..Results from these studies will provide new information that can be used to design new therapeutic options to treat HT in women with hyperandrogenemia, such as in PCOS. ..
  17. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..Our proposed studies will therefore determine the role of adipose renin-angiotensin system in development of adult hypertension and obesity in growth restricted newborns. ..
  18. Remodeling of the guinea pig intrinsic cardiac plexus with chronic heart disease
    ELIZABETH MARIE SOUTHERLAND; Fiscal Year: 2013
    ....
  19. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
  20. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2013
    ....
  21. PERL: A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2013
    ..It is difficult to overstate how significant this finding would be, both from the perspective of public health and that of persons with diabetes. ..
  22. Renal Angiotensin II Receptor Function in Obesity
    Tahir Hussain; Fiscal Year: 2013
    ..Following treatments, proximal tubule NKA activity and various components of the renin angiotensin system will be determined...
  23. Risk factor-enhanced microvascular responses to ischemia-reperfusion.
    D Neil Granger; Fiscal Year: 2013
    ....
  24. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ....
  25. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..The goal is the development of a medicine with proven safety that can be easily taken by mouth both during a flare-up of the disease as well as a maintenance treatment. ..
  26. PPG-Genetic and Signaling Mechanisms in the Central Regulation of Blood Pressure
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..The findings will clarify important mechanisms, which may allow translation into improved treatment for cardiovascular and metabolic dysfunction in hypertension and obesity-hypertension. ..
  27. Angiotensin converting enzyme, angiotensin II, and arrhythmia
    Samuel C Dudley; Fiscal Year: 2010
    ..This application presents a novel hypothesis about why RAS activation causes arrhythmias, contributing to atrial fibrillation (AF) and heart failure (HF)-associated sudden death. ..
  28. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2013
    ..It is hoped that such studies may lead to targeted therapeutic options with a favorable risk-benefit profile that can prevent or slow the development of diabetic nephropathy. ..
  29. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..selective H3-receptor agonists) mimicking the beneficial effects of preconditioning and enabling a safe and effective treatment of congestive heart failure with natriuretic peptides. and ATP sensory/sympathetic nerves will be assessed ..
  30. Sodium-chloride co-transporter regulation in the kidney
    Alicia A McDonough; Fiscal Year: 2013
    ..The renin angiotensin system (RAS) stimulates NCC activity via an AngII-WNK4-SPAK dependent pathway...
  31. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ-VILLALOBOS; Fiscal Year: 2013
    ..abstract_text> ..
  32. KLF15 in vascular disease
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..Further, the results of these studies may provide the foundation for novel approaches to the treatment of this highly morbid and mortal disease. ..
  33. CVD protection mechanisms involving ACE2/Ang-(1-7) axis
    Mohan K Raizada; Fiscal Year: 2013
    ..Finally, we believe that ACE2/Ang-(1-7) based concept will have an immediate impact not only in HD therapeutics, but will lead to the development of novel cardioprotective strategies in patients undergoing anthracyclin chemotherapy. ..
  34. Mechanical Signaling Mechanisms in Cardiac Tissue
    David E Dostal; Fiscal Year: 2013
    ....
  35. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas J Wang; Fiscal Year: 2010
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..
  36. Angiotensin II, IGF-1 and Skeletal Muscle Atrophy
    Patrice Delafontaine; Fiscal Year: 2013
    ..These findings will allow development of innovative therapies to treat cachexia in chronic conditions in which the RAS is activated. ..
  37. Ah Receptor and Endothelin-Dependent Hypertension
    Mary K Walker; Fiscal Year: 2010
    ..Our results will define a novel regulatory pathway for suppression of hypoxia-induced ET- 1, which could be use to develop new therapies for ET-1-dependent cardiovascular diseases. ..
  38. Role of micro RNAs in renin cell differentiation
    ROBERTO ARIEL GOMEZ; Fiscal Year: 2013
    ..Information gained from the proposed studies may help children and adults affected by kidney diseases and hypertension. ..
  39. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ....
  40. MODifiable Effectors of Renin System Activation: Treatment Evaluation
    John P Forman; Fiscal Year: 2013
    ..lower 25-hydroxyvitamin D (25[OH]D) and higher uric acid levels are associated with activation of the renin angiotensin system, endothelial dysfunction, and elevation of blood pressure in humans...
  41. Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    DOMINIC JAMES SMIRAGLIA; Fiscal Year: 2013
    ..This will increase the power of the pairwise comparisons between primary and metastatic tumors and will ultimately allow for dissection of multiple molecular routes of metastatic spread. ..
  42. Cytokines and Sympathetic Activation in Heart Failure
    Robert B Felder; Fiscal Year: 2013
    ..These studies will identify currently unrecognized mechanisms driving the sympathetic nervous system in heart failure, and thus potential targets for preventive intervention. ..
  43. Low birth weight, the kidney, and hypertension
    Barbara T Alexander; Fiscal Year: 2013
    ..We report that the renin angiotensin system (RAS) plays a critical role in hypertensive IUGR;however, peripheral and intrarenal levels of the RAS are ..
  44. Regulation of AT1R-signaling and pathology in vessels through microRNA
    Sadashiva S Karnik; Fiscal Year: 2013
    ..There is potential relevance for this knowledge base in understanding normal functioning aorta, vasculature in brain, kidney and heart, as well as the pathology of heart failure, atherosclerosis and aortic aneurysm. ..
  45. Angiotensin-II, Hypothalamic Inflammation and Neurogenic Hypertension
    ANNETTE DIANE DE KLOET; Fiscal Year: 2012
    ..This is of particular relevance to public health because uncovering the mechanisms of Ang-II regulation of inflammation and cardiovascular function may lead to new strategies for the treatment and prevention of hypertension. ..
  46. Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)
    ROBERT CHARLES SPETH; Fiscal Year: 2013
    ..And, that novel therapeutic agents targeting ACE-2 might be developed to promote the beneficial aspects of its antagonism of the pathophysiological actions of the RAS. ..
  47. Renin angiotensin system and connexin43
    Samuel C Dudley; Fiscal Year: 2013
    ..Specifically, this application will give a more complete picture of the pro-arrhythmic effects of AngII on heart, which could lead to new diagnostic and therapeutic interventions. ..
  48. Role of the CNS in Inappropriate Vasopressin Release Associated with Cirrhosis
    JOSEPH D WALCH; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The results from these studies will determine the mechanisms that contribute to the pathophysiology of fluid retention in a chronic disease state that is reported to be the 5th leading cause of death in the USA. ..
  49. AT2 Receptors in the RVLM: Regulation of Sympathetic Outflow in Heart Failure
    Lie Gao; Fiscal Year: 2013
    ..They will highlight the importance of a balance between AT1 and AT2 receptor signaling in setting the level of sympatho-excitation and identify possible new targets for therapy in CHF. ..
  50. SIGNIFICANCE OF ANGIOTENSINOGEN VARIANTS IN HYPERTENSION
    CURT DANIEL SIGMUND; Fiscal Year: 2013
    ..abstract_text> ..
  51. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The renin angiotensin system (RAS) has a central role in cardiovascular homeostasis and development of renal, vascular, and cardiac pathologies...
  52. ACE2 as a target for pulmonary hypertension therapeutics
    MOHAN K contact RAIZADA; Fiscal Year: 2010
    ..Our objective in this investigation is to use genetically modified hematopoietic stem cells to deliver ACE2 or Ang-(1-7) to the site of pulmonary injury to orchestrate a robust pulmonary vascular repair and reverse PH. ..
  53. Brain-targeted ACE2 over-expression on angiotensin-II-mediated hypertension
    ERIC D LAZARTIGUES; Fiscal Year: 2012
    ..If confirmed, ACE2 could become a new target for the treatment of Hypertension and other cardiovascular diseases. ..
  54. Role of Chymase In The Post-Myocardial Infarction Heart
    Ahsan Husain; Fiscal Year: 2013
    ..The proposed identification of the downstream targets of chymase should provide a foundation for the development of novel therapeutic agents directed toward patients with cardiovascular disease. ..
  55. Gonadotropins in a female model of age-induced hypertension
    KATHRYN L SANDBERG; Fiscal Year: 2012
    ..endothelial dysfunction, renal oxidative stress and activation of the vasoconstrictor arm of the renin angiotensin system (RAS) in vascular, renal and adipose tissues...
  56. Vascular ANGII/Jak2 in progression of renal disease
    Peter P Sayeski; Fiscal Year: 2012
    ..of NO and ROS production, plasma and renal tissue ANGII and levels of components of the intrarenal renin angiotensin system at the transcript, protein and activity level...
  57. Novel Formulation of Topical Losartan for Treatment of Wounds in Aging
    JEREMY DAVID WALSTON; Fiscal Year: 2013
    ..Such results will facilitate the rapid translation of these findings into human subjects, and have great potential to rapidly shift the present wound healing care paradigm in older adults. ..
  58. Neurohumoral adaptations to chronic intermittent hypoxia
    Steven W Mifflin; Fiscal Year: 2012
    ..abstract_text> ..
  59. Renal AT2 Receptors in Hypertension
    ROBERT MUNSON CAREY; Fiscal Year: 2013
    ..This application will increase our understanding of the mechanisms whereby the kidney renin-angiotensin system regulates salt and water excretion, suggesting new molecular targets for the treatment and prevention of hypertension. ..
  60. Lead and Vascular Reactivity to Acute Stress in Children
    Brooks Gump; Fiscal Year: 2009
    ..These effects of lead on cardiovascular risk factors may occur at very low levels, levels well below the thresholds currently adopted by the CDC for deleterious effects of lead. ..
  61. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ....
  62. CCN3 and aortic aneurysm
    Zhiyong Lin; Fiscal Year: 2013
    ..And finally, in Aim 3, we will determine the importance of CCN3 in AA formation in KLF15-KO animals. The results of these studies may provide the foundation for novel approaches to the treatment of this disease. ..
  63. BRADYKININ VASCULAR INFLUENCE AND ACE INHIBITION
    BEN ZIMMERMAN; Fiscal Year: 1993
    ....
  64. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..abstract_text> ..
  65. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009
    ..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
  66. CELLULAR MECHANISMS FOR ANGIOTENSIN RESPONSES IN BRAIN
    ELISABETH TALLANT; Fiscal Year: 1999
    ..These studies will extend our understanding of the role of the central RAS in blood pressure regulation and provide insight into the pathology of forms of essential human hypertension where endogenous levels of Ang II are elevated. ..
  67. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  68. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  69. REGULATION OF CARDIAC SECOND MESSENGERS BY ANGIOTENSIN
    Kenneth Baker; Fiscal Year: 1993
    ..Identification of the precursor genes for the renin angiotensin system in the heart and quantifiable production of translatable product (angiotensin II) suggests that ..
  70. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    ..With this information, specific preventive and therapeutic measures could then be tested as to their efficacy in retarding the development of these complications. ..
  71. Angiotensin II Receptor Blockade and Adipose Tissue Inflammation in Obesity
    Kevin Davy; Fiscal Year: 2009
    ..Activation of the renin angiotensin system (RAS) is an important mechanism by which obesity leads to hypertension...
  72. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    ..This project aims to examine whether Vitamin D supplementation in obesity reduces RAS activity in humans. ..
  73. TRANSGENIC IN HYPERTENSION--RAS RIBOZYNE INHIBITION
    John Mullins; Fiscal Year: 1992
    ..These techniques, once established with the key genes of the renin angiotensin system, will in principle be applicable universally to any other gene...