renin angiotensin system

Summary

Summary: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.

Top Publications

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
  2. pmc The renin angiotensin system and the metabolic syndrome
    Annette D de Kloet
    Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
    Physiol Behav 100:525-34. 2010
  3. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
  4. ncbi Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat
    Christos Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Diabetes 53:989-97. 2004
  5. ncbi The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice
    J C B Ferreira
    School of Physical Education and Sport, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Regul Integr Comp Physiol 294:R26-32. 2008
  6. ncbi Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis
    Yoshiko Ihara
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 43:455-64. 2007
  7. ncbi Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
  8. ncbi Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
  9. ncbi Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)
    Lucia Maria Procopciuc
    Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 14 Padis Street, Cluj Napoca, Romania
    Eur J Intern Med 21:414-8. 2010
  10. doi The role of the central renin-angiotensin system in Parkinson's disease
    Birgit Mertens
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Renin Angiotensin Aldosterone Syst 11:49-56. 2010

Detail Information

Publications284 found, 100 shown here

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ..The full text of this article is available at http://www. circresaha.org...
  2. pmc The renin angiotensin system and the metabolic syndrome
    Annette D de Kloet
    Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
    Physiol Behav 100:525-34. 2010
    The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic ..
  3. ncbi Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    Regina Kunz
    Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
    Ann Intern Med 148:30-48. 2008
    ..Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, remains uncertain...
  4. ncbi Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat
    Christos Tikellis
    Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Diabetes 53:989-97. 2004
    ..These findings provide a possible mechanism for the reduced incidence of new-onset diabetes that has been observed in clinical trials of RAS blockade...
  5. ncbi The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in mice
    J C B Ferreira
    School of Physical Education and Sport, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Am J Physiol Regul Integr Comp Physiol 294:R26-32. 2008
    Sympathetic hyperactivity (SH) and renin angiotensin system (RAS) activation are commonly associated with heart failure (HF), even though the relative contribution of these factors to the cardiac derangement is less understood...
  6. ncbi Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis
    Yoshiko Ihara
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 43:455-64. 2007
    ..Upregulation of the ligand-RAGE pathway via AT1R is an essential mechanism in diabetic atherosclerosis, implying that ARB might decrease diabetic atherogenesis by inhibiting ligand-RAGE signals...
  7. ncbi Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
    ..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
  8. ncbi Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    Robert M Carey
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Endocr Rev 24:261-71. 2003
    ..The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components...
  9. ncbi Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)
    Lucia Maria Procopciuc
    Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 14 Padis Street, Cluj Napoca, Romania
    Eur J Intern Med 21:414-8. 2010
    ..The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS)...
  10. doi The role of the central renin-angiotensin system in Parkinson's disease
    Birgit Mertens
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Renin Angiotensin Aldosterone Syst 11:49-56. 2010
    ..They include inhibition of the angiotensin-converting enzyme, blockade of the angiotensin II type 1 receptor and stimulation of the angiotensin II type 2 receptor...
  11. ncbi Improvement of insulin sensitivity by antagonism of the renin-angiotensin system
    Erik J Henriksen
    Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007
    ..Collectively, these findings support targeting the RAS in the design of interventions to improve metabolic and cardiovascular function in conditions of insulin resistance associated with prediabetes and type 2 diabetes...
  12. ncbi The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition
    Steven A Atlas
    James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    J Manag Care Pharm 13:9-20. 2007
    ..Dysregulation of the RAAS plays an important role in the pathogenesis of cardiovascular and renal disorders...
  13. doi Role of the renin-angiotensin system in vascular inflammation
    Chiara Marchesi
    Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Trends Pharmacol Sci 29:367-74. 2008
    ..The present review addresses recent findings regarding the pathophysiology of vascular inflammation in hypertension, focusing specifically on the role of Ang II...
  14. ncbi Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver
    Georgina Paizis
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Victoria, Australia
    Gastroenterology 123:1667-76. 2002
    Angiotensin II (ANG II) has profibrotic actions in the heart and kidney, whereas blockade of the renin angiotensin system (RAS) attenuates injury...
  15. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..These results are compatible with the concept of multilocus and multi-gene effects in complex diseases that would be missed with conventional approaches...
  16. ncbi Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cells
    William B Strawn
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Haematol 126:120-6. 2004
    ..The presence of Ang II receptors in both haematopoietic-lineage BMC and MSC, and the de novo synthesis of Ang II by MSC suggest a potential autocrine-paracrine mechanism for local RAS-mediated regulation of haematopoiesis...
  17. ncbi It's renin in the brain: transgenic animals elucidate the brain renin angiotensin system
    Michael Bader
    Circ Res 90:8-10. 2002
  18. pmc Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring
    Daniela Grigore
    Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 293:R804-11. 2007
    ..We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by ..
  19. ncbi Glomerular permeability defect in hypertension is dependent on renin angiotensin system activation
    Riccardo Candido
    Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy
    Am J Hypertens 18:844-50. 2005
    ..The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS)...
  20. doi Update on tissue renin-angiotensin systems
    Michael Bader
    Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
    J Mol Med (Berl) 86:615-21. 2008
    ..This review summarizes the recent findings on the importance of tissue RAS in the most relevant cardiovascular organs...
  21. ncbi Renin-angiotensin system and cardiovascular risk
    Roland E Schmieder
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Lancet 369:1208-19. 2007
    ..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
  22. ncbi Hypertensive myocardial fibrosis
    Cesare Cuspidi
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Via F Sforza 35, 20122 Milano, Italy
    Nephrol Dial Transplant 21:20-3. 2006
  23. ncbi Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation
    Mollie Jurewicz
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 18:1093-102. 2007
    ..Because their chemotaxis is enhanced by AngII, this creates a potential inflammatory amplification system...
  24. ncbi Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure
    George W Booz
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    J Mol Cell Cardiol 34:1443-53. 2002
    ..The central focus of this review is on recent studies suggesting that modulation or activation of JAK-STAT signaling by ANG II has pathological consequences for heart function...
  25. ncbi Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL
    Dick de Zeeuw
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Kidney Int 65:2309-20. 2004
    ....
  26. ncbi Circulating renin Angiotensin system in childhood chronic renal failure: marked increase of Angiotensin-(1-7) in end-stage renal disease
    Ana C Simoes e Silva
    Department of Pediatrics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
    Pediatr Res 60:734-9. 2006
    ..Our data showed different circulating RAS profiles between hypertensive and in normotensive CRF subjects. Marked changes in plasma Ang-(1-7) were associated with the presence of hypertension and progression of kidney dysfunction...
  27. ncbi The role of angiotensin II in cognition and behaviour
    Paul R Gard
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    Eur J Pharmacol 438:1-14. 2002
    ..The role of the brain renin-angiotensin system in human psychopathology remains to be fully explored...
  28. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  29. ncbi Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats
    Manuel Portero-Otin
    Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLLEIDA PCiTAL Parc Científic Agroalimentari de Lleida, 25008 Lleida, Spain
    Biochem Biophys Res Commun 368:528-35. 2008
    b>Renin angiotensin system (RAS) worsens diabetic nephropathy (DN) by increasing oxidative stress...
  30. ncbi Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease
    Carlos M Ferrario
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:121-8. 2006
    ....
  31. doi Renin-angiotensin system revisited
    F Fyhrquist
    Minerva Institute for Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
    J Intern Med 264:224-36. 2008
    ..Great expectations are now generated by the introduction of renin inhibitors. Indeed, RAS regulates much more and diverse physiological functions than previously believed...
  32. pmc Local adipose tissue renin-angiotensin system
    Lisa A Cassis
    Graduate Center for Nutritional Sciences, Wethington Building, Room 521b, 900 South Limestone Street, University of Kentucky, Lexington, KY 40536 0200, USA
    Curr Hypertens Rep 10:93-8. 2008
    ..Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension...
  33. ncbi Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors
    Yuichiro Ishiyama
    Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
    Hypertension 43:970-6. 2004
    ..These results provide evidence for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotensin-(1-7)...
  34. pmc Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study
    C E Mogensen
    Department of Medicine, M, Kommunehospitalet, University Hospital, DK 8000 Aarhus C, Denmark
    BMJ 321:1440-4. 2000
    ..To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and type 2 diabetes...
  35. ncbi The renin-angiotensin system and diabetic nephropathy
    Susan B Gurley
    Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
    Semin Nephrol 27:144-52. 2007
    ..We provide a general review of the RAS and its role in diabetic nephropathy...
  36. pmc Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
    Johannes Stegbauer
    Department of Nephrology, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 106:14942-7. 2009
    Angiotensin II is the principle effector molecule of the renin angiotensin system (RAS)...
  37. ncbi Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
    ..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
  38. doi Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial
    Pere Gines
    Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Hepatology 48:204-13. 2008
    ..01 for all compared to placebo). Thirst was significantly more common in patients treated with satavaptan compared to those treated with placebo, whereas the frequency of other adverse events was similar among groups...
  39. ncbi Myocardial infarction increases ACE2 expression in rat and humans
    Louise M Burrell
    Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
    Eur Heart J 26:369-75; discussion 322-4. 2005
    ..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
  40. ncbi Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments
    Aaron J Trask
    The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston Salem, North Carolina 27157, USA
    Cardiovasc Drug Rev 25:162-74. 2007
    ..This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum...
  41. ncbi Angiotensin-(1-7) and the renin-angiotensin system
    Robson A S Santos
    Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Curr Opin Nephrol Hypertens 16:122-8. 2007
    ..In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system...
  42. ncbi Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)
    Iwona Kucharewicz
    Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland
    Hypertension 40:774-9. 2002
    ..Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)-evoked release of NO and prostacyclin...
  43. ncbi Origin of aldosterone in the rat heart
    Elise P Gomez-Sanchez
    Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, 1500 East Woodrow Wilson Drive 151, Jackson, Mississippi 39216, USA
    Endocrinology 145:4796-802. 2004
    ..In conclusion, we found that the level of aldosterone content in the healthy rat heart in vivo is significantly lower than that reported elsewhere and reflects plasma levels in intact rats...
  44. ncbi Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    Masato Furuhashi
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Hypertension 42:76-81. 2003
    ..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
  45. ncbi Diabetes, hypertension, and cardiovascular disease: an update
    J R Sowers
    SUNY Downstate Medical Center and VAMC, Brooklyn, NY, USA
    Hypertension 37:1053-9. 2001
    ..This update also examines the role of the renin-angiotensin system in the increased risk for CVD in diabetic patients and the impact of interrupting this system on the development of clinical diabetes as well as CVD...
  46. doi Activation of a local renin angiotensin system in podocytes by glucose
    Raghu V Durvasula
    Univ of Washington School of Medicine, Division of Nephrology, Box 356521, Seattle, WA 98195, USA
    Am J Physiol Renal Physiol 294:F830-9. 2008
    ..Taken together, the resultant activation of a local renin angiotensin system by high glucose may promote progressive podocyte injury and loss in diabetic nephropathy.
  47. pmc Localisation of renin-angiotensin system (RAS) components in breast
    M Tahmasebi
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
    Br J Cancer 95:67-74. 2006
    ..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
  48. ncbi Angiotensin-converting enzyme II in the heart and the kidney
    Ursula Danilczyk
    IMBA, Institute for Molecular Biotechnology, Austrian Academy of Sciences, D Bohr Gasse 7, A 1030 Vienna, Austria
    Circ Res 98:463-71. 2006
    ..The development of drugs that could activate ACE2 function would allow extending our treatment options in diabetic nephropathy, heart failure, or hypertension...
  49. doi Genetics of the human renin angiotensin system
    Xavier Jeunemaitre
    INSERM U772, College de France, 11 place Marcelin Berthelot, Paris, France
    J Mol Med (Berl) 86:637-41. 2008
    The genes coding for the renin angiotensin system have been extensively studied...
  50. ncbi Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients
    J Redon
    Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
    Pharmacogenomics J 5:14-20. 2005
    ..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan...
  51. doi Aliskiren: renin inhibitor for hypertension management
    Judy W M Cheng
    Massachusetts College of Pharmacy and Health Sciences and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Ther 30:31-47. 2008
    ..Certain agents that modify the RAAS can control blood pressure and improve cardiovascular outcomes. Aliskiren is the first of a new class of antihypertensive agents known as renin inhibitors...
  52. pmc New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
    ..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
  53. pmc Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production
    Hiroyuki Kobori
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Kidney Int 61:579-85. 2002
    ..The present study tested the hypothesis that enhanced intrarenal angiotensinogen formation during Ang II infusion is reflected by secretion into the tubular fluid leading to increased urinary excretion of angiotensinogen (UAGT)...
  54. pmc Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans
    Alan Daugherty
    Saha Cardiovascular Research Center, University of Kentucky, BBSRB, room B 243, Lexington, KY 40536 0509, USA
    Curr Atheroscler Rep 12:167-73. 2010
    The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease...
  55. pmc Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients
    Walkíria Wingester Vilas-Boas
    Laboratório de Hipertensão, Departamento de Fisiologia e Biofisica, ICB UFMG, Av Antonio Carlos, 6627, Belo Horizonte, MG, 31270 901, Brazil
    World J Gastroenterol 14:6824-30. 2008
    ....
  56. ncbi Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE study
    X Jeunemaitre
    Laboratoire de Biologie Moleculaire, Ilôt des Mariniers, Assistance Publique Hopitaux de Paris, Hopital Broussais, France
    Hum Genet 99:66-73. 1997
    ..19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis...
  57. pmc Renal renin-angiotensin system
    Atsuhiro Ichihara
    Keio University School of Medicine, Tokyo, USA
    Contrib Nephrol 143:117-30. 2004
  58. ncbi Mast cells activate the renin angiotensin system and contribute to migraine: a hypothesis
    Hisham Ba'albaki
    Heart Health Center Cardiology, and University of Alabama, Florence, AL 35631, USA
    Headache 48:1499-505. 2008
    ..The renin angiotensin system and its peptides are well represented in the mammalian central nervous system and can also promote ..
  59. ncbi Role of renin angiotensin system in angiogenesis: it is still elusive
    Toshihiro Ichiki
    Arterioscler Thromb Vasc Biol 24:622-4. 2004
  60. ncbi Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction?
    John J V McMurray
    Department of Cardiology, Western Infirmary, Glasgow, Scotland, G12 8QQ, UK
    Circulation 110:3281-8. 2004
  61. ncbi Effect of Valsartan on hospitalization: results from Val-HeFT
    Peter Carson
    Department of Veterans Affairs, Medical Center, Washington, DC 20422, USA
    J Card Fail 9:164-71. 2003
    ..5% versus placebo (P <.001). This article analyzes all-cause and investigator-assessed HF hospitalization in Val-HeFT overall and in subgroups defined by preexisting HF therapy...
  62. pmc Role of the renin angiotensin system on bone marrow-derived stem cell function and its impact on skeletal muscle angiogenesis
    Micheline M de Resende
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 42:437-44. 2010
    ..ES) is impaired in the SS/Mcwi rats and that this effect is related to a dysregulation of the renin angiotensin system (RAS) that is normalized by the replacement of chromosome 13 derived from the Brown Norway rat (SS-13(BN)/..
  63. ncbi HIV protease inhibitors activate the adipocyte renin angiotensin system
    Franck Boccara
    Faculte de Medecine Saint Antoine, INSERM, UMRS938, Paris, France
    Antivir Ther 15:363-75. 2010
    ..Whether hypertension and cardiovascular events could result from the adipocyte renin angiotensin system (RAS) overactivation has never been investigated.
  64. ncbi The role of renin angiotensin system blockade in the treatment of atrial fibrillation
    Polychronis Dilaveris
    Department of Cardiology, University of Athens Medical School, Hippokratin Hospital, Greece
    Curr Drug Targets Cardiovasc Haematol Disord 5:387-403. 2005
    ..Particular interest has been generated in the role of renin angiotensin system (RAS) blockade in reversing the electrical and structural remodeling of diseased atria...
  65. ncbi How to explain the differences between renin angiotensin system modulators
    Bernard I Levy
    Center of Cardiovascular Research, Inserm Lariboisiere, U689, 41 Boulevard de la Chapelle, 75010 Paris, France
    Am J Hypertens 18:134S-141S. 2005
    ..These basic concepts deserve a second reading and reevaluation to discuss differences in vascular protection in large clinical trials with different classes of drugs acting on the renin-angiotensin system...
  66. ncbi Protective effect of long-term angiotensin II inhibition
    Nidia Basso
    Cardiovascular Pathophysiology Institute, Department of Pathology, School of Medicine, University of Buenos Aires, Argentina
    Am J Physiol Heart Circ Physiol 293:H1351-8. 2007
    ..An outstanding finding was the significant and similar prolongation of life span in both groups of treated animals compared with untreated control animals...
  67. ncbi Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats
    H Deniz
    Department of Internal Medicine, Marmara University Medical School, Istanbul, Turkey
    Transplant Proc 38:483-6. 2006
    ..In conclusion, the results of our study suggested that renin angiotensin inhibition down-regulates fibrogenic cytokine expression in rats displaying tacrolimus nephrotoxicity...
  68. ncbi Pharmacologic blockade of the renin-angiotensin system: vascular benefits beyond commonly understood pharmacologic actions
    James P Tsikouris
    School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Pharmacotherapy 23:1141-52. 2003
    ..Overall, understanding the distinct coronary vascular benefits of these agents will emphasize the importance of using them, particularly ACE inhibitors, to improve outcomes in patients with coronary atherosclerotic disease...
  69. ncbi The renin angiotensin system as a risk factor for coronary artery disease
    J A Farmer
    Section of Cardiology, Ben Taub General Hospital and Baylor College of Medicine, 6550 Fannin, Houston, TX 77030, USA
    Curr Atheroscler Rep 3:117-24. 2001
    The renin angiotensin system was demonstrated to play a significant role in the genesis of hypertension and regulation of vascular tone over 100 years ago...
  70. ncbi A common polymorphism in the renin angiotensin system is associated with differential outcome of antihypertensive pharmacotherapy prescribed to Brazilian older women
    Clayton F Moraes
    Postgraduation Program Stricto Sensu in Gerontology, Catholic University of Brasilia UCB, Geriatrics Service, Hospital of the Catholic University of Brasília, Brasilia DF, Brazil
    Clin Chim Acta 396:70-5. 2008
    ..Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy...
  71. pmc Changes in the renin angiotensin system during the development of colorectal cancer liver metastases
    Jaclyn H Neo
    Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    BMC Cancer 10:134. 2010
    Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model...
  72. ncbi Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia
    Ioanna Bouba
    Genetics Unit, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45500, Ioannina, Greece
    Eur J Obstet Gynecol Reprod Biol 110:8-11. 2003
    ..In conclusion, we found an association between the angiotensinogen variant 235T and preeclampsia as well as an interaction between the variant 235T and the two other genes studied...
  73. ncbi Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertension
    E Pamies-Andreu
    Unidad de Hipertensión Arterial y Lípidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
    J Hum Hypertens 17:187-91. 2003
    ..Although there is no association between salt sensitivity and the different studied genotypes of the RAAS and of the GNB3, our data show a greater risk for salt sensitivity among carriers of the W allele of the CYP11B2 1C polymorphism...
  74. pmc Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study
    Ihab Hajjar
    Harvard Medical School, Institute for Aging Research Hebrew SeniorLife Beth Israel Deaconess Medical Center, Division of Gerontology, Boston, MA 02130, USA
    Stroke 41:635-40. 2010
    Our objective was to investigate the associations between polymorphisms in representative genes of the renin angiotensin system with measures of cerebral blood flow regulation in older adults.
  75. pmc Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuria
    Mahmut Ilker Yilmaz
    Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
    Clin J Am Soc Nephrol 4:535-41. 2009
    ..Moreover, PTX3 has been suggested to represent a novel mortality risk factor, and elevated PTX3 levels have been shown to accompany increased albuminuria among patients with chronic kidney disease (CKD)...
  76. ncbi The expanding role of oxidative stress, renin angiotensin system, and beta-cell dysfunction in the cardiometabolic syndrome and Type 2 diabetes mellitus
    Guido Lastra
    Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
    Antioxid Redox Signal 9:943-54. 2007
    ..Hyperglycemia, elevated circulating fatty acids, inadequate local activation of renin angiotensin system, and chronic low grade inflammation are conditions that coexist in the CMS and DM2 that turn out to be ..
  77. ncbi The renin angiotensin system and Alzheimer's disease
    P Amouyel
    INSERM U508, Institut Pasteur de Lille, France
    Ann N Y Acad Sci 903:437-41. 2000
    ..As a major player of vascular homeostasis, the renin angiotensin system (RAS) proteins constitute an interesting source of candidate genes...
  78. ncbi Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathy
    Tadashi Konoshita
    Third Department of Internal Medicine, Fukui University School of Medicine, Matsuoka, Fukui 910 1193, Japan
    Diabetes Care 29:848-52. 2006
    ..The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method...
  79. ncbi Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor
    Alan Daugherty
    Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
    Circulation 110:3849-57. 2004
    ..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
  80. ncbi Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio
    Shigeyuki Wakahara
    Third Department of Internal Medicine, Fukui University School of Medicine, 23 3, Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
    Endocrinology 148:2453-7. 2007
    ..Thus, ACE2 may exert pivotal effects on cardiovascular and renal conditions...
  81. ncbi Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophy
    Y Sakata
    Department of Internal Medicine and Therapeutics, Osaka University, Osaka University Graduate School of Medicine, Suita, Japan
    J Am Coll Cardiol 37:293-9. 2001
    OBJECTIVES: This study aimed to characterize the difference between renin angiotensin system (RAS)-dependent and RAS-independent hypertrophy and their differential contribution to the transition to heart failure...
  82. ncbi Intrarenal activation of renin angiotensin system in the development of cyclosporine A induced chronic nephrotoxicity
    Ming hua Shang
    Department of Nephrology, First People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Chin Med J (Engl) 121:983-8. 2008
    ..This study was conducted to detect the levels of renin and angiotensin II (ANGII) both in renal tissue and plasma from kidney transplantation patients suffering from CAN...
  83. ncbi Renin angiotensin system and gender differences in the cardiovascular system
    Marcus Fischer
    Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Cardiovasc Res 53:672-7. 2002
    ....
  84. ncbi Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    T Lau
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Diabetologia 47:240-8. 2004
    ..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
  85. ncbi Angiotensin II receptor antagonists
    M Burnier
    Department of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland
    Lancet 355:637-45. 2000
    ..Trials now underway will demonstrate whether angiotensin II receptor antagonists can prevent target-organ damage and reduce cardiovascular morbidity and mortality. If they do, these compounds might one day replace ACE inhibitors...
  86. doi Managing cardiovascular and renal risk: the potential of direct renin inhibition
    Peter S Sever
    International Centre for Circulatory Health, Imperial College London, UK
    J Renin Angiotensin Aldosterone Syst 10:65-76. 2009
    ..In this article, we review the antihypertensive efficacy of aliskiren and explore its potential in the management of cardiovascular and renal risk...
  87. ncbi The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition
    S P Ip
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Mol Endocrinol 31:563-71. 2003
    ..The significance of its reversibility and adaptability following chronic hypoxia may be of physiological relevance to the pancreas...
  88. ncbi Blood pressure reduction is not the only determinant of outcome
    Peter S Sever
    International Centre for Circulatory Health, Imperial College London, 59 N Wharf Rd, London, W2 1PG, UK
    Circulation 113:2754-72; discussion 2773-4. 2006
  89. ncbi Effects of eprosartan versus hydrochlorothiazide on markers of vascular oxidation and inflammation and blood pressure (renin-angiotensin system antagonists, oxidation, and inflammation)
    Syed T Rahman
    Emory University School of Medicine, Division of Cardiology, Atlanta, Georgia 30303, USA
    Am J Cardiol 89:686-90. 2002
    ....
  90. ncbi Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system
    Dae Gil Kang
    Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Korea
    Am J Chin Med 30:87-93. 2002
    ..These results suggest that danshen has an anti-hypertensive effect through the inhibition of ACE, an essential regulatory enzyme of RAS...
  91. ncbi Intravenous delivery of PTH/PTHrP type 1 receptor cDNA to rats decreases heart rate, blood pressure, renal tone, renin angiotensin system, and stress-induced cardiovascular responses
    Samuel Fritsch
    Renovascular Pharmacology and Physiology INSERM, University of Louis Pasteur School of Medicine, Strasbourg, France
    J Am Soc Nephrol 15:2588-600. 2004
    ..In addition, these results revealed that PTH1R-mediated mechanisms might have protective effects against cardiovascular stress-induced responses, including stimulations in heart rate and RAS...
  92. doi Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studies
    Arlene B Chapman
    Emory University School of Medicine, 1364 Clifton Road, Room GG23, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 3:1197-204. 2008
    ..Findings from CRISP and the rationale for interventions in ADPKD are described, and the design of the HALT-PKD clinical trial is outlined...
  93. ncbi Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease
    A Boonstra
    Department of Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
    Semin Nephrol 21:580-92. 2001
    ..Such information is vital, not only to make sense of observed associations, but all the more so if one wants to apply the insights on the role of genetic factors into better strategies for disease intervention...
  94. ncbi Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease
    E Lovati
    Division of Nephrology and Hypertension, Inselspital, University of Berne, Berne, Switzerland
    Kidney Int 60:46-54. 2001
    ..Genes encoding for angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and aldosterone synthase (CYP11B2) are candidates for abnormal blood pressure regulation...
  95. ncbi Targeting mechanisms of hypertensive vascular disease with dual calcium channel and renin-angiotensin system blockade
    M R Weir
    Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 21:770-9. 2007
    ....
  96. ncbi Angiotensinogen and plasminogen activator inhibitor-1 gene polymorphism in relation to chronic allograft dysfunction
    Kadriye Reis
    Department of Nephrology, Gazi University, Ankara, Turkey
    Clin Transplant 19:10-4. 2005
    ..001 and <0.05). Determination of AGT M235T and PAI-1 genotypes prior to transplantation may help identify patients who at risk for chronic renal transplant dysfunction...
  97. ncbi The renin-angiotensin-aldosterone system: a pivotal role in insulin sensitivity and glycemic control
    Jennifer M Perkins
    Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, Nashville, Tennesse 37232 0475, USA
    Curr Opin Endocrinol Diabetes Obes 15:147-52. 2008
    ....
  98. ncbi The potential role of prorenin in diabetic nephropathy
    Roland E Schmieder
    Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Germany
    J Hypertens 25:1323-6. 2007
  99. ncbi Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitus
    Radomir D Stevanovic
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Renin Angiotensin Aldosterone Syst 6:78-83. 2005
    ..1+/-17.6 ml/minute/1.73 m2). When it was above the median, the RPF response was also larger (62.2+/-13.9 ml/minute/1.73 m2; p=0.006). Renin response to ACE-I and ARB confirms activation of the RAS in diabetic patients...
  100. ncbi Genetic polymorphisms of the renin-angiotensin system in end-stage renal disease
    Monika Buraczynska
    Laboratory for Molecular Diagnostics of Multifactorial Diseases, Department of Nephrology, University Medical School, Dr K Jaczewskiego 8, 20 954 Lublin, Poland
    Nephrol Dial Transplant 21:979-83. 2006
    ..We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients...
  101. ncbi Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia
    Florian Herse
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
    Hypertension 49:604-11. 2007
    ..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...

Research Grants96

  1. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    Shannon Glaser; Fiscal Year: 2009
    ....
  2. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2009
    ....
  3. Fibrotic Sequelae of Childhood Renal Disease
    Agnes Fogo; Fiscal Year: 2007
    ..Mol Cell 3:1-10, 1999. Nishimura H, Ichikawa I: What have we learned from gene targeting studies for the renin angiotensin system of the kidney? Intern Med, 38:315-323,1999...
  4. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2004
    ..The hypotheses to be tested are that androgens play a role in PM hypertension by activating the RAS, stimulating endothelin synthesis and oxidative stress. ..
  5. Hormonal Mechanisms of Postmenopausal Hypertension
    JANE RECKELHOFF; Fiscal Year: 2005
    ..The hypotheses to be tested are that androgens play a role in PM hypertension by activating the RAS, stimulating endothelin synthesis and oxidative stress. ..
  6. ANG II: Permissive role to maintain vascular relaxation
    JULIAN LOMBARD; Fiscal Year: 2007
    ..abstract_text> ..
  7. ANG II: Permissive role to maintain vascular relaxation
    JULIAN LOMBARD; Fiscal Year: 2003
    ..abstract_text> ..
  8. A multicenter clinical trial of allopurinol to prevent GFR loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2012
    ..The reduction in morbidity and mortality resulting from this would have a major impact on the lives of T1D patients as well as on society at large, significantly reducing the human and financial costs associated with this condition. ..
  9. REGULATION OF CARDIAC HYPERTROPHY BY ANGIOTENSINS
    Kenneth Baker; Fiscal Year: 1990
    ..The hypotheses to be tested will more broadly define hormonally-mediated mechanisms of cardiac hypertrophy and will be relevant in the treatment of diseases such as hypertension...
  10. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ....
  11. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    RAOUF KHALIL; Fiscal Year: 2009
    ....
  12. HORMONAL REGULATION OF BLOOD PRESSURE
    Michal Laniado Schwartzman; Fiscal Year: 2012
    ..Project 1 focuses on the interactions between the CYP4A-derived 20-HETE and the renin angiotensin system and investigate the role of endothelial ACE in 20-HETE-mediated vascular dysfunction and hypertension...
  13. RENIN/ANGIOTENSIN SYSTEM AND FIBRINOLYSIS IN HUMANS
    Douglas Vaughan; Fiscal Year: 1999
    ....
  14. RENIN/ANGIOTENSIN SYSTEM AND FIBRINOLYSIS IN HUMANS
    Douglas Vaughan; Fiscal Year: 2001
    ....
  15. RENIN/ANGIOTENSIN SYSTEM AND FIBRINOLYSIS IN HUMANS
    Douglas Vaughan; Fiscal Year: 2000
    ....
  16. Regulation of AT1R-signaling and pathology in vessels through microRNA
    Sadashiva S Karnik; Fiscal Year: 2012
    ..Hypertensive and hypertrophic disease remains a major public health concern and adequate treatment for reversal of these diseases is currently lacking. ..
  17. Insulin action in human cardiac and skeletal muscle microvasculature
    Zhenqi Liu; Fiscal Year: 2010
    ....
  18. Role of the renin-angiotensin system in sexual dimorphisms in the development of
    Jennifer C Sullivan; Fiscal Year: 2010
    ....
  19. Role of the renin-angiotensin system in sexual dimorphisms in the development of
    Jennifer Sullivan; Fiscal Year: 2009
    ....
  20. Targeted Overexpression and Ablation of Renin in Connecting Tubule
    Jean Marc Lalouel; Fiscal Year: 2007
    ..The work should advance diagnosis and treatment of hypertension. [unreadable] [unreadable] [unreadable]..
  21. Design of a Multicenter Clinical Trial of Allopurinol to Prevent GFR Loss in T1D
    S MICHAEL MAUER; Fiscal Year: 2011
    ..The reduction in morbidity and mortality resulting from this would have a major impact on the lives of T1D patients as well as on society at large, significantly reducing the human and financial costs associated with this condition. ..
  22. Central actions of angiotensin II in the control of fluid balance
    Daniel Yee; Fiscal Year: 2009
    ..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
  23. Central actions of angiotensin II in the control of fluid balance
    LORI MARIE FLANAGAN CATO; Fiscal Year: 2011
    ..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
  24. Central actions of angiotensin II in the control of fluid balance
    DANIEL K contact YEE; Fiscal Year: 2010
    ..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
  25. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2010
    ..The results of this project will provide new insights on the role of Ang II/Ang (1-7) balance in the pathophysiology of ischemic stroke, and thus facilitate the development of novel therapeutic targets for ischemic stroke. ..
  26. Role of the Renin-Angiotensin System in the Regulation of Biliary Proliferation
    SHANNON STROUD GLASER; Fiscal Year: 2010
    ....
  27. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..The goal is the development of a medicine with proven safety that can be easily taken by mouth both during a flare-up of the disease as well as a maintenance treatment. ..
  28. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..Our proposed studies will therefore determine the role of adipose renin-angiotensin system in development of adult hypertension and obesity in growth restricted newborns. ..
  29. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2009
    ..Our proposed studies will therefore determine the role of adipose renin-angiotensin system in development of adult hypertension and obesity in growth restricted newborns. ..
  30. Oxidative Stress and Left Ventiricular Diastolic Function
    SAMUEL DUDLEY; Fiscal Year: 2009
    ..detailed budget for initial budget period from through direct costs only 12/01/08 11/30/09 ..
  31. Role of Brain Renin-Angiotensin System in Insulin-Induced Sympathoexcitation
    Martin Muntzel; Fiscal Year: 2003
    ..abstract_text> ..
  32. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2010
    ....
  33. Crystal Associated Renal Inflammation and Treatment Options
    Saeed Khan; Fiscal Year: 2009
    ....
  34. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2002
    ..abstract_text> ..
  35. BRADYKININ VASCULAR INFLUENCE AND ACE INHIBITION
    BEN ZIMMERMAN; Fiscal Year: 1991
    ....
  36. BRADYKININ VASCULAR INFLUENCE AND ACE INHIBITION
    BEN ZIMMERMAN; Fiscal Year: 1993
    ....
  37. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..abstract_text> ..
  38. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2009
    ..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
  39. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2007
    ..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
  40. ROLE OF GLUCOSE IN hAT1 GENE EXPRESSION
    Thomas Thekkumkara; Fiscal Year: 2006
    ..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
  41. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    Rosario Scalia; Fiscal Year: 2009
    ..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
  42. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
  43. CELLULAR MECHANISMS FOR ANGIOTENSIN RESPONSES IN BRAIN
    ELISABETH TALLANT; Fiscal Year: 1999
    ..These studies will extend our understanding of the role of the central RAS in blood pressure regulation and provide insight into the pathology of forms of essential human hypertension where endogenous levels of Ang II are elevated. ..
  44. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2001
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  45. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2002
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  46. ANGIOTENSIN II--ENDOTHELIAL DISORDERS IN HEART FAILURE
    Maria Crespo; Fiscal Year: 2000
    ..The proposed studies should provide the rationale for the development of new therapeutic strategies. ..
  47. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  48. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  49. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2003
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  50. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2000
    ..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
  51. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2004
    ..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
  52. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2007
    ..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
  53. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2002
    ..This will lead to improved outcomes in adulthood. ..
  54. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2003
    ..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
  55. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2006
    ..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
  56. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2004
    ..This will lead to improved outcomes in adulthood. ..
  57. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  58. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2003
    ..This will lead to improved outcomes in adulthood. ..
  59. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2005
    ..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
  60. ENDOTHELIAL CELL-RENIN ANGIOTENSIN PATHWAYS
    Victor Dzau; Fiscal Year: 1990
    ..By elucidating the cellular mechanisms of angiotensin synthesis and secretion as well as the factors which regulate these processes, we should improve our understanding of the biology of this fundamental cardiovascular regulatory system...
  61. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2010
    ....
  62. REGULATION OF DEVELOPMENTAL RENAL HEMODYNAMICS
    Michael Solhaug; Fiscal Year: 1999
    ..Highly activated renal vasoconstrictors, such as the renin angiotensin system and renal sympathetic nerves are considered to maintain the unique conditions in the developing renal ..
  63. Angiotensin: A Link Between Obesity and Hypertension
    Lisa Cassis; Fiscal Year: 2009
    ..Since the principal cause of death in obese patients is cardiovascular disease, results from these studies are clinically significant. ..
  64. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 1999
    ..With this information, specific preventive and therapeutic measures could then be tested as to their efficacy in retarding the development of these complications. ..
  65. MECHANISMS UNDERLYING CARDIOVASCULAR RISKS IN DIABETES
    Gordon Williams; Fiscal Year: 2000
    ..With this information, specific preventive and therapeutic measures could then be tested as to their efficacy in retarding the development of these complications. ..
  66. CENTRAL ANGIOTENSIN IN FLUID BALANCE AND HYPERTENSION
    M Phillips; Fiscal Year: 1990
    ..The expression of mas-oncogene mRNA in response to angiotensin II will be studied. The goal of the project is to focus on the locus of tissue angiotensin gene expression which contributes to the development of hypertension...
  67. MOLECULAR BIOLOGY OF RENIN AND ITS GENE
    John Baxter; Fiscal Year: 1991
    The renin angiotensin system (RAS) is critically involved in the pathogenesis of hypertension, congestive heart failure and renal failure, and converting enzyme blockers of the system are one of the most important drugs used to treat ..
  68. PHYSIOLOGICAL ROLE AF AII-INDUCED ADENOSINE RELEASE
    Edwin Jackson; Fiscal Year: 1990
    ..Finally, I will determine if adenosine mediates the "short-loop" negative feedback control of renin release by examining this feedback loop in the absence and presence of adenosine receptor blockade...
  69. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    JOHNATHAN TUNE; Fiscal Year: 2009
    ..The goal of our research is to delineate the precise mechanisms of obesity-related cardiovascular disease and thus establish a rationale for therapeutic intervention. ..
  70. In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin Resistance
    ROSARIO G SCALIA; Fiscal Year: 2010
    ..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
  71. Angiotensin II Receptor Blockade and Adipose Tissue Inflammation in Obesity
    Kevin Davy; Fiscal Year: 2009
    ..Activation of the renin angiotensin system (RAS) is an important mechanism by which obesity leads to hypertension...
  72. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    ..This project aims to examine whether Vitamin D supplementation in obesity reduces RAS activity in humans. ..
  73. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2009
    ..It is hoped that such studies may lead to targeted therapeutic options with a favorable risk-benefit profile that can prevent or slow the development of diabetic nephropathy. ..
  74. The Impact of Antenatal Steroid Exposure on the Intrarenal Renin-Angiotensin
    James C Rose; Fiscal Year: 2011
    ..PROJECT/PERFORIVIANCE SITE(S) (If additional space is needed, use Project/Perfomiance Site Format Page) Project/ ..
  75. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2002
    ..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..
  76. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2003
    ..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..
  77. TRANSGENIC IN HYPERTENSION--RAS RIBOZYNE INHIBITION
    John Mullins; Fiscal Year: 1990
    ..These techniques, once established with the key genes of the renin angiotensin system, will in principle be applicable universally to any other gene...
  78. FUNCTIONAL ANALYSIS OF VASCULAR ANGIOTENSIN II
    BEN ZIMMERMAN; Fiscal Year: 1993
    ..These considerations may be important in relation to the involvement of locally formed AII in hypertension...
  79. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2004
    ..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..
  80. ANGIOTENSIN II RECEPTOR SIGNALING DOMAINS
    R Alexander; Fiscal Year: 2001
    ..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..
  81. ORAL CALCIUM IN PREGNANT WOMEN WITH CHRONIC HYPERTENSION
    Phyllis August; Fiscal Year: 1993
    ..Alterations in calcium metabolism, the renin angiotensin system, and intracellular free calcium concentration have been identified in this high risk population...
  82. REGULATION OF CARDIAC SECOND MESSENGERS BY ANGIOTENSIN
    Kenneth Baker; Fiscal Year: 1991
    ..Identification of the precursor genes for the renin angiotensin system in the heart and quantifiable production of translatable product (angiotensin II) suggests that ..