Genomes and Genes
renin angiotensin system
Summary: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Publications284 found, 100 shown here
- A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9M Donoghue
Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
Circ Res 87:E1-9. 2000..The full text of this article is available at http://www. circresaha.org...
- The renin angiotensin system and the metabolic syndromeAnnette D de Kloet
Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
Physiol Behav 100:525-34. 2010The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic ..
- Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal diseaseRegina Kunz
Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
Ann Intern Med 148:30-48. 2008..Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, remains uncertain...
- Improved islet morphology after blockade of the renin- angiotensin system in the ZDF ratChristos Tikellis
Danielle Alberti Memorial Centre for Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
Diabetes 53:989-97. 2004..These findings provide a possible mechanism for the reduced incidence of new-onset diabetes that has been observed in clinical trials of RAS blockade...
- The role of local and systemic renin angiotensin system activation in a genetic model of sympathetic hyperactivity-induced heart failure in miceJ C B Ferreira
School of Physical Education and Sport, Medical School, University of Sao Paulo, Sao Paulo, Brazil
Am J Physiol Regul Integr Comp Physiol 294:R26-32. 2008Sympathetic hyperactivity (SH) and renin angiotensin system (RAS) activation are commonly associated with heart failure (HF), even though the relative contribution of these factors to the cardiac derangement is less understood...
- Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosisYoshiko Ihara
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Mol Cell Cardiol 43:455-64. 2007..Upregulation of the ligand-RAGE pathway via AT1R is an essential mechanism in diabetic atherosclerosis, implying that ARB might decrease diabetic atherogenesis by inhibiting ligand-RAGE signals...
- Inflammation in hypertensionCarmine Savoia
Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
Curr Opin Nephrol Hypertens 15:152-8. 2006..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
- Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulationRobert M Carey
Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Endocr Rev 24:261-71. 2003..The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components...
- Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)Lucia Maria Procopciuc
Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 14 Padis Street, Cluj Napoca, Romania
Eur J Intern Med 21:414-8. 2010..The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS)...
- The role of the central renin-angiotensin system in Parkinson's diseaseBirgit Mertens
Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
J Renin Angiotensin Aldosterone Syst 11:49-56. 2010..They include inhibition of the angiotensin-converting enzyme, blockade of the angiotensin II type 1 receptor and stimulation of the angiotensin II type 2 receptor...
- Improvement of insulin sensitivity by antagonism of the renin-angiotensin systemErik J Henriksen
Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007..Collectively, these findings support targeting the RAS in the design of interventions to improve metabolic and cardiovascular function in conditions of insulin resistance associated with prediabetes and type 2 diabetes...
- The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibitionSteven A Atlas
James J Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
J Manag Care Pharm 13:9-20. 2007..Dysregulation of the RAAS plays an important role in the pathogenesis of cardiovascular and renal disorders...
- Role of the renin-angiotensin system in vascular inflammationChiara Marchesi
Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Trends Pharmacol Sci 29:367-74. 2008..The present review addresses recent findings regarding the pathophysiology of vascular inflammation in hypertension, focusing specifically on the role of Ang II...
- Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liverGeorgina Paizis
Department of Medicine, University of Melbourne, Austin and Repatriation Medical Center, Victoria, Australia
Gastroenterology 123:1667-76. 2002Angiotensin II (ANG II) has profibrotic actions in the heart and kidney, whereas blockade of the renin angiotensin system (RAS) attenuates injury...
- Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interactionChia Ti Tsai
Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
Atherosclerosis 195:172-80. 2007..These results are compatible with the concept of multilocus and multi-gene effects in complex diseases that would be missed with conventional approaches...
- Renin-angiotensin system expression in rat bone marrow haematopoietic and stromal cellsWilliam B Strawn
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Br J Haematol 126:120-6. 2004..The presence of Ang II receptors in both haematopoietic-lineage BMC and MSC, and the de novo synthesis of Ang II by MSC suggest a potential autocrine-paracrine mechanism for local RAS-mediated regulation of haematopoiesis...
- It's renin in the brain: transgenic animals elucidate the brain renin angiotensin systemMichael Bader
Circ Res 90:8-10. 2002
- Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspringDaniela Grigore
Department of Physiology and the Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
Am J Physiol Regul Integr Comp Physiol 293:R804-11. 2007..We hypothesize that the renin angiotensin system (RAS), a regulatory system important in the long-term control of blood pressure, may be programmed by ..
- Glomerular permeability defect in hypertension is dependent on renin angiotensin system activationRiccardo Candido
Department of Medicina Clinica and Neurologia, University of Trieste, Trieste, Italy
Am J Hypertens 18:844-50. 2005..The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS)...
- Update on tissue renin-angiotensin systemsMichael Bader
Max Delbrück Centrum for Molecular Medicine MDC, Berlin, Germany
J Mol Med (Berl) 86:615-21. 2008..This review summarizes the recent findings on the importance of tissue RAS in the most relevant cardiovascular organs...
- Renin-angiotensin system and cardiovascular riskRoland E Schmieder
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
Lancet 369:1208-19. 2007..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
- Hypertensive myocardial fibrosisCesare Cuspidi
Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Via F Sforza 35, 20122 Milano, Italy
Nephrol Dial Transplant 21:20-3. 2006
- Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammationMollie Jurewicz
Transplantation Research Center, Renal Division, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
J Am Soc Nephrol 18:1093-102. 2007..Because their chemotaxis is enhanced by AngII, this creates a potential inflammatory amplification system...
- Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failureGeorge W Booz
The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
J Mol Cell Cardiol 34:1443-53. 2002..The central focus of this review is on recent studies suggesting that modulation or activation of JAK-STAT signaling by ANG II has pathological consequences for heart function...
- Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAALDick de Zeeuw
Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
Kidney Int 65:2309-20. 2004....
- Circulating renin Angiotensin system in childhood chronic renal failure: marked increase of Angiotensin-(1-7) in end-stage renal diseaseAna C Simoes e Silva
Department of Pediatrics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
Pediatr Res 60:734-9. 2006..Our data showed different circulating RAS profiles between hypertensive and in normotensive CRF subjects. Marked changes in plasma Ang-(1-7) were associated with the presence of hypertension and progression of kidney dysfunction...
- The role of angiotensin II in cognition and behaviourPaul R Gard
School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
Eur J Pharmacol 438:1-14. 2002..The role of the brain renin-angiotensin system in human psychopathology remains to be fully explored...
- Weight loss and the renin-angiotensin-aldosterone systemStefan Engeli
Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
Hypertension 45:356-62. 2005..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
- Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic ratsManuel Portero-Otin
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLLEIDA PCiTAL Parc Científic Agroalimentari de Lleida, 25008 Lleida, Spain
Biochem Biophys Res Commun 368:528-35. 2008b>Renin angiotensin system (RAS) worsens diabetic nephropathy (DN) by increasing oxidative stress...
- Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular diseaseCarlos M Ferrario
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Am J Cardiol 98:121-8. 2006....
- Renin-angiotensin system revisitedF Fyhrquist
Minerva Institute for Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Intern Med 264:224-36. 2008..Great expectations are now generated by the introduction of renin inhibitors. Indeed, RAS regulates much more and diverse physiological functions than previously believed...
- Local adipose tissue renin-angiotensin systemLisa A Cassis
Graduate Center for Nutritional Sciences, Wethington Building, Room 521b, 900 South Limestone Street, University of Kentucky, Lexington, KY 40536 0200, USA
Curr Hypertens Rep 10:93-8. 2008..Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension...
- Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptorsYuichiro Ishiyama
Hypertension and Vascular Disease Center, Wake Forest University Health Science Center, Winston Salem, NC 27157, USA
Hypertension 43:970-6. 2004..These results provide evidence for an effect of angiotensin II blockade on cardiac ACE 2 mRNA that may be due to direct blockade of AT1a receptors or a modulatory effect of increased angiotensin-(1-7)...
- Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) studyC E Mogensen
Department of Medicine, M, Kommunehospitalet, University Hospital, DK 8000 Aarhus C, Denmark
BMJ 321:1440-4. 2000..To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and type 2 diabetes...
- The renin-angiotensin system and diabetic nephropathySusan B Gurley
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
Semin Nephrol 27:144-52. 2007..We provide a general review of the RAS and its role in diabetic nephropathy...
- Role of the renin-angiotensin system in autoimmune inflammation of the central nervous systemJohannes Stegbauer
Department of Nephrology, Heinrich Heine University Dusseldorf, 40225 Dusseldorf, Germany
Proc Natl Acad Sci U S A 106:14942-7. 2009Angiotensin II is the principle effector molecule of the renin angiotensin system (RAS)...
- Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indicationsGunter Wolf
Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
Kidney Int 67:799-812. 2005..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
- Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trialPere Gines
Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
Hepatology 48:204-13. 2008..01 for all compared to placebo). Thirst was significantly more common in patients treated with satavaptan compared to those treated with placebo, whereas the frequency of other adverse events was similar among groups...
- Myocardial infarction increases ACE2 expression in rat and humansLouise M Burrell
Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
Eur Heart J 26:369-75; discussion 322-4. 2005..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
- Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatmentsAaron J Trask
The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston Salem, North Carolina 27157, USA
Cardiovasc Drug Rev 25:162-74. 2007..This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum...
- Angiotensin-(1-7) and the renin-angiotensin systemRobson A S Santos
Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Curr Opin Nephrol Hypertens 16:122-8. 2007..In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system...
- Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)Iwona Kucharewicz
Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland
Hypertension 40:774-9. 2002..Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)-evoked release of NO and prostacyclin...
- Origin of aldosterone in the rat heartElise P Gomez-Sanchez
Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, 1500 East Woodrow Wilson Drive 151, Jackson, Mississippi 39216, USA
Endocrinology 145:4796-802. 2004..In conclusion, we found that the level of aldosterone content in the healthy rat heart in vivo is significantly lower than that reported elsewhere and reflects plasma levels in intact rats...
- Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertensionMasato Furuhashi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
Hypertension 42:76-81. 2003..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
- Diabetes, hypertension, and cardiovascular disease: an updateJ R Sowers
SUNY Downstate Medical Center and VAMC, Brooklyn, NY, USA
Hypertension 37:1053-9. 2001..This update also examines the role of the renin-angiotensin system in the increased risk for CVD in diabetic patients and the impact of interrupting this system on the development of clinical diabetes as well as CVD...
- Activation of a local renin angiotensin system in podocytes by glucoseRaghu V Durvasula
Univ of Washington School of Medicine, Division of Nephrology, Box 356521, Seattle, WA 98195, USA
Am J Physiol Renal Physiol 294:F830-9. 2008..Taken together, the resultant activation of a local renin angiotensin system by high glucose may promote progressive podocyte injury and loss in diabetic nephropathy.
- Localisation of renin-angiotensin system (RAS) components in breastM Tahmasebi
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Br J Cancer 95:67-74. 2006..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
- Angiotensin-converting enzyme II in the heart and the kidneyUrsula Danilczyk
IMBA, Institute for Molecular Biotechnology, Austrian Academy of Sciences, D Bohr Gasse 7, A 1030 Vienna, Austria
Circ Res 98:463-71. 2006..The development of drugs that could activate ACE2 function would allow extending our treatment options in diabetic nephropathy, heart failure, or hypertension...
- Genetics of the human renin angiotensin systemXavier Jeunemaitre
INSERM U772, College de France, 11 place Marcelin Berthelot, Paris, France
J Mol Med (Berl) 86:637-41. 2008The genes coding for the renin angiotensin system have been extensively studied...
- Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patientsJ Redon
Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
Pharmacogenomics J 5:14-20. 2005..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan...
- Aliskiren: renin inhibitor for hypertension managementJudy W M Cheng
Massachusetts College of Pharmacy and Health Sciences and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Ther 30:31-47. 2008..Certain agents that modify the RAAS can control blood pressure and improve cardiovascular outcomes. Aliskiren is the first of a new class of antihypertensive agents known as renin inhibitors...
- New angiotensinsJasmina Varagic
The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Mol Med (Berl) 86:663-71. 2008..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
- Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen productionHiroyuki Kobori
Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
Kidney Int 61:579-85. 2002..The present study tested the hypothesis that enhanced intrarenal angiotensinogen formation during Ang II infusion is reflected by secretion into the tubular fluid leading to increased urinary excretion of angiotensinogen (UAGT)...
- Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humansAlan Daugherty
Saha Cardiovascular Research Center, University of Kentucky, BBSRB, room B 243, Lexington, KY 40536 0509, USA
Curr Atheroscler Rep 12:167-73. 2010The renin angiotensin system (RAS) has profound effects on atherosclerosis development in animal models, which is partially complimented by evidence in the human disease...
- Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patientsWalkíria Wingester Vilas-Boas
Laboratório de Hipertensão, Departamento de Fisiologia e Biofisica, ICB UFMG, Av Antonio Carlos, 6627, Belo Horizonte, MG, 31270 901, Brazil
World J Gastroenterol 14:6824-30. 2008....
- Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease: the CORGENE studyX Jeunemaitre
Laboratoire de Biologie Moleculaire, Ilôt des Mariniers, Assistance Publique Hopitaux de Paris, Hopital Broussais, France
Hum Genet 99:66-73. 1997..19, P = 0.04) in patients with low-risk status. These overall results are not in favor of a role of these RAS genetic polymorphisms in the development of coronary atherosclerosis...
- Renal renin-angiotensin systemAtsuhiro Ichihara
Keio University School of Medicine, Tokyo, USA
Contrib Nephrol 143:117-30. 2004
- Mast cells activate the renin angiotensin system and contribute to migraine: a hypothesisHisham Ba'albaki
Heart Health Center Cardiology, and University of Alabama, Florence, AL 35631, USA
Headache 48:1499-505. 2008..The renin angiotensin system and its peptides are well represented in the mammalian central nervous system and can also promote ..
- Role of renin angiotensin system in angiogenesis: it is still elusiveToshihiro Ichiki
Arterioscler Thromb Vasc Biol 24:622-4. 2004
- Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction?John J V McMurray
Department of Cardiology, Western Infirmary, Glasgow, Scotland, G12 8QQ, UK
Circulation 110:3281-8. 2004
- Effect of Valsartan on hospitalization: results from Val-HeFTPeter Carson
Department of Veterans Affairs, Medical Center, Washington, DC 20422, USA
J Card Fail 9:164-71. 2003..5% versus placebo (P <.001). This article analyzes all-cause and investigator-assessed HF hospitalization in Val-HeFT overall and in subgroups defined by preexisting HF therapy...
- Role of the renin angiotensin system on bone marrow-derived stem cell function and its impact on skeletal muscle angiogenesisMicheline M de Resende
Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Physiol Genomics 42:437-44. 2010..ES) is impaired in the SS/Mcwi rats and that this effect is related to a dysregulation of the renin angiotensin system (RAS) that is normalized by the replacement of chromosome 13 derived from the Brown Norway rat (SS-13(BN)/..
- HIV protease inhibitors activate the adipocyte renin angiotensin systemFranck Boccara
Faculte de Medecine Saint Antoine, INSERM, UMRS938, Paris, France
Antivir Ther 15:363-75. 2010..Whether hypertension and cardiovascular events could result from the adipocyte renin angiotensin system (RAS) overactivation has never been investigated.
- The role of renin angiotensin system blockade in the treatment of atrial fibrillationPolychronis Dilaveris
Department of Cardiology, University of Athens Medical School, Hippokratin Hospital, Greece
Curr Drug Targets Cardiovasc Haematol Disord 5:387-403. 2005..Particular interest has been generated in the role of renin angiotensin system (RAS) blockade in reversing the electrical and structural remodeling of diseased atria...
- How to explain the differences between renin angiotensin system modulatorsBernard I Levy
Center of Cardiovascular Research, Inserm Lariboisiere, U689, 41 Boulevard de la Chapelle, 75010 Paris, France
Am J Hypertens 18:134S-141S. 2005..These basic concepts deserve a second reading and reevaluation to discuss differences in vascular protection in large clinical trials with different classes of drugs acting on the renin-angiotensin system...
- Protective effect of long-term angiotensin II inhibitionNidia Basso
Cardiovascular Pathophysiology Institute, Department of Pathology, School of Medicine, University of Buenos Aires, Argentina
Am J Physiol Heart Circ Physiol 293:H1351-8. 2007..An outstanding finding was the significant and similar prolongation of life span in both groups of treated animals compared with untreated control animals...
- Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in ratsH Deniz
Department of Internal Medicine, Marmara University Medical School, Istanbul, Turkey
Transplant Proc 38:483-6. 2006..In conclusion, the results of our study suggested that renin angiotensin inhibition down-regulates fibrogenic cytokine expression in rats displaying tacrolimus nephrotoxicity...
- Pharmacologic blockade of the renin-angiotensin system: vascular benefits beyond commonly understood pharmacologic actionsJames P Tsikouris
School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
Pharmacotherapy 23:1141-52. 2003..Overall, understanding the distinct coronary vascular benefits of these agents will emphasize the importance of using them, particularly ACE inhibitors, to improve outcomes in patients with coronary atherosclerotic disease...
- The renin angiotensin system as a risk factor for coronary artery diseaseJ A Farmer
Section of Cardiology, Ben Taub General Hospital and Baylor College of Medicine, 6550 Fannin, Houston, TX 77030, USA
Curr Atheroscler Rep 3:117-24. 2001The renin angiotensin system was demonstrated to play a significant role in the genesis of hypertension and regulation of vascular tone over 100 years ago...
- A common polymorphism in the renin angiotensin system is associated with differential outcome of antihypertensive pharmacotherapy prescribed to Brazilian older womenClayton F Moraes
Postgraduation Program Stricto Sensu in Gerontology, Catholic University of Brasilia UCB, Geriatrics Service, Hospital of the Catholic University of Brasília, Brasilia DF, Brazil
Clin Chim Acta 396:70-5. 2008..Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy...
- Changes in the renin angiotensin system during the development of colorectal cancer liver metastasesJaclyn H Neo
Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
BMC Cancer 10:134. 2010Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model...
- Interaction between the polymorphisms of the renin-angiotensin system in preeclampsiaIoanna Bouba
Genetics Unit, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45500, Ioannina, Greece
Eur J Obstet Gynecol Reprod Biol 110:8-11. 2003..In conclusion, we found an association between the angiotensinogen variant 235T and preeclampsia as well as an interaction between the variant 235T and the two other genes studied...
- Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertensionE Pamies-Andreu
Unidad de Hipertensión Arterial y Lípidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
J Hum Hypertens 17:187-91. 2003..Although there is no association between salt sensitivity and the different studied genotypes of the RAAS and of the GNB3, our data show a greater risk for salt sensitivity among carriers of the W allele of the CYP11B2 1C polymorphism...
- Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston studyIhab Hajjar
Harvard Medical School, Institute for Aging Research Hebrew SeniorLife Beth Israel Deaconess Medical Center, Division of Gerontology, Boston, MA 02130, USA
Stroke 41:635-40. 2010Our objective was to investigate the associations between polymorphisms in representative genes of the renin angiotensin system with measures of cerebral blood flow regulation in older adults.
- Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuriaMahmut Ilker Yilmaz
Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
Clin J Am Soc Nephrol 4:535-41. 2009..Moreover, PTX3 has been suggested to represent a novel mortality risk factor, and elevated PTX3 levels have been shown to accompany increased albuminuria among patients with chronic kidney disease (CKD)...
- The expanding role of oxidative stress, renin angiotensin system, and beta-cell dysfunction in the cardiometabolic syndrome and Type 2 diabetes mellitusGuido Lastra
Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
Antioxid Redox Signal 9:943-54. 2007..Hyperglycemia, elevated circulating fatty acids, inadequate local activation of renin angiotensin system, and chronic low grade inflammation are conditions that coexist in the CMS and DM2 that turn out to be ..
- The renin angiotensin system and Alzheimer's diseaseP Amouyel
INSERM U508, Institut Pasteur de Lille, France
Ann N Y Acad Sci 903:437-41. 2000..As a major player of vascular homeostasis, the renin angiotensin system (RAS) proteins constitute an interesting source of candidate genes...
- Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathyTadashi Konoshita
Third Department of Internal Medicine, Fukui University School of Medicine, Matsuoka, Fukui 910 1193, Japan
Diabetes Care 29:848-52. 2006..The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method...
- Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptorAlan Daugherty
Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
Circulation 110:3849-57. 2004..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
- Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratioShigeyuki Wakahara
Third Department of Internal Medicine, Fukui University School of Medicine, 23 3, Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
Endocrinology 148:2453-7. 2007..Thus, ACE2 may exert pivotal effects on cardiovascular and renal conditions...
- Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophyY Sakata
Department of Internal Medicine and Therapeutics, Osaka University, Osaka University Graduate School of Medicine, Suita, Japan
J Am Coll Cardiol 37:293-9. 2001OBJECTIVES: This study aimed to characterize the difference between renin angiotensin system (RAS)-dependent and RAS-independent hypertrophy and their differential contribution to the transition to heart failure...
- Intrarenal activation of renin angiotensin system in the development of cyclosporine A induced chronic nephrotoxicityMing hua Shang
Department of Nephrology, First People s Hospital, Shanghai Jiaotong University, Shanghai, China
Chin Med J (Engl) 121:983-8. 2008..This study was conducted to detect the levels of renin and angiotensin II (ANGII) both in renal tissue and plasma from kidney transplantation patients suffering from CAN...
- Renin angiotensin system and gender differences in the cardiovascular systemMarcus Fischer
Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Cardiovasc Res 53:672-7. 2002....
- Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic isletsT Lau
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
Diabetologia 47:240-8. 2004..This study aimed, primarily, to investigate the existence of a local angiotensin-generating system in the pancreatic islets and, secondly, to elucidate its role in regulating insulin secretion...
- Angiotensin II receptor antagonistsM Burnier
Department of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland
Lancet 355:637-45. 2000..Trials now underway will demonstrate whether angiotensin II receptor antagonists can prevent target-organ damage and reduce cardiovascular morbidity and mortality. If they do, these compounds might one day replace ACE inhibitors...
- Managing cardiovascular and renal risk: the potential of direct renin inhibitionPeter S Sever
International Centre for Circulatory Health, Imperial College London, UK
J Renin Angiotensin Aldosterone Syst 10:65-76. 2009..In this article, we review the antihypertensive efficacy of aliskiren and explore its potential in the management of cardiovascular and renal risk...
- The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic conditionS P Ip
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
J Mol Endocrinol 31:563-71. 2003..The significance of its reversibility and adaptability following chronic hypoxia may be of physiological relevance to the pancreas...
- Blood pressure reduction is not the only determinant of outcomePeter S Sever
International Centre for Circulatory Health, Imperial College London, 59 N Wharf Rd, London, W2 1PG, UK
Circulation 113:2754-72; discussion 2773-4. 2006
- Effects of eprosartan versus hydrochlorothiazide on markers of vascular oxidation and inflammation and blood pressure (renin-angiotensin system antagonists, oxidation, and inflammation)Syed T Rahman
Emory University School of Medicine, Division of Cardiology, Atlanta, Georgia 30303, USA
Am J Cardiol 89:686-90. 2002....
- Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin systemDae Gil Kang
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Korea
Am J Chin Med 30:87-93. 2002..These results suggest that danshen has an anti-hypertensive effect through the inhibition of ACE, an essential regulatory enzyme of RAS...
- Intravenous delivery of PTH/PTHrP type 1 receptor cDNA to rats decreases heart rate, blood pressure, renal tone, renin angiotensin system, and stress-induced cardiovascular responsesSamuel Fritsch
Renovascular Pharmacology and Physiology INSERM, University of Louis Pasteur School of Medicine, Strasbourg, France
J Am Soc Nephrol 15:2588-600. 2004..In addition, these results revealed that PTH1R-mediated mechanisms might have protective effects against cardiovascular stress-induced responses, including stimulations in heart rate and RAS...
- Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studiesArlene B Chapman
Emory University School of Medicine, 1364 Clifton Road, Room GG23, Atlanta, GA 30322, USA
Clin J Am Soc Nephrol 3:1197-204. 2008..Findings from CRISP and the rationale for interventions in ADPKD are described, and the design of the HALT-PKD clinical trial is outlined...
- Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal diseaseA Boonstra
Department of Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
Semin Nephrol 21:580-92. 2001..Such information is vital, not only to make sense of observed associations, but all the more so if one wants to apply the insights on the role of genetic factors into better strategies for disease intervention...
- Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal diseaseE Lovati
Division of Nephrology and Hypertension, Inselspital, University of Berne, Berne, Switzerland
Kidney Int 60:46-54. 2001..Genes encoding for angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and aldosterone synthase (CYP11B2) are candidates for abnormal blood pressure regulation...
- Targeting mechanisms of hypertensive vascular disease with dual calcium channel and renin-angiotensin system blockadeM R Weir
Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
J Hum Hypertens 21:770-9. 2007....
- Angiotensinogen and plasminogen activator inhibitor-1 gene polymorphism in relation to chronic allograft dysfunctionKadriye Reis
Department of Nephrology, Gazi University, Ankara, Turkey
Clin Transplant 19:10-4. 2005..001 and <0.05). Determination of AGT M235T and PAI-1 genotypes prior to transplantation may help identify patients who at risk for chronic renal transplant dysfunction...
- The renin-angiotensin-aldosterone system: a pivotal role in insulin sensitivity and glycemic controlJennifer M Perkins
Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, Nashville, Tennesse 37232 0475, USA
Curr Opin Endocrinol Diabetes Obes 15:147-52. 2008....
- The potential role of prorenin in diabetic nephropathyRoland E Schmieder
Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nurnberg, Germany
J Hypertens 25:1323-6. 2007
- Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitusRadomir D Stevanovic
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Renin Angiotensin Aldosterone Syst 6:78-83. 2005..1+/-17.6 ml/minute/1.73 m2). When it was above the median, the RPF response was also larger (62.2+/-13.9 ml/minute/1.73 m2; p=0.006). Renin response to ACE-I and ARB confirms activation of the RAS in diabetic patients...
- Genetic polymorphisms of the renin-angiotensin system in end-stage renal diseaseMonika Buraczynska
Laboratory for Molecular Diagnostics of Multifactorial Diseases, Department of Nephrology, University Medical School, Dr K Jaczewskiego 8, 20 954 Lublin, Poland
Nephrol Dial Transplant 21:979-83. 2006..We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients...
- Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsiaFlorian Herse
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
Hypertension 49:604-11. 2007..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...
- Role of the Renin-Angiotensin System in the Regulation of Biliary ProliferationShannon Glaser; Fiscal Year: 2009....
- Fibrotic Sequelae of Childhood Renal DiseaseAgnes Fogo; Fiscal Year: 2007..Mol Cell 3:1-10, 1999. Nishimura H, Ichikawa I: What have we learned from gene targeting studies for the renin angiotensin system of the kidney? Intern Med, 38:315-323,1999...
- RENIN/ANGIOTENSIN SYSTEM AND FIBRINOLYSIS IN HUMANSDouglas Vaughan; Fiscal Year: 2001....
- Insulin action in human cardiac and skeletal muscle microvasculatureZhenqi Liu; Fiscal Year: 2010....
- Role of the renin-angiotensin system in sexual dimorphisms in the development ofJennifer C Sullivan; Fiscal Year: 2010....
- Targeted Overexpression and Ablation of Renin in Connecting TubuleJean Marc Lalouel; Fiscal Year: 2007..The work should advance diagnosis and treatment of hypertension. ..
- Central actions of angiotensin II in the control of fluid balanceDaniel Yee; Fiscal Year: 2009..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Central actions of angiotensin II in the control of fluid balanceLORI MARIE FLANAGAN CATO; Fiscal Year: 2011..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Central actions of angiotensin II in the control of fluid balanceDANIEL K contact YEE; Fiscal Year: 2010..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic StrokeYanfang Chen; Fiscal Year: 2010..The results of this project will provide new insights on the role of Ang II/Ang (1-7) balance in the pathophysiology of ischemic stroke, and thus facilitate the development of novel therapeutic targets for ischemic stroke. ..
- Role of the Renin-Angiotensin System in the Regulation of Biliary ProliferationSHANNON STROUD GLASER; Fiscal Year: 2010....
- Crystal Associated Renal Inflammation and Treatment OptionsSaeed R Khan; Fiscal Year: 2010....
- Vitamin D: A Negative Regulator of Renin ExpressionYan Chun Li; Fiscal Year: 2003..abstract_text> ..
- ROLE OF GLUCOSE IN hAT1 GENE EXPRESSIONThomas Thekkumkara; Fiscal Year: 2009..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
- ROLE OF GLUCOSE IN hAT1 GENE EXPRESSIONThomas Thekkumkara; Fiscal Year: 2007..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceRosario Scalia; Fiscal Year: 2009..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceROSARIO G SCALIA; Fiscal Year: 2010..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROMEJulie Ingelfinger; Fiscal Year: 2004..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
- Angiotensin: A Link Between Obesity and HypertensionLisa Cassis; Fiscal Year: 2007..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
- Intercellular Signaling in Obstructive NephropathyROBERT CHEVALIER; Fiscal Year: 2005..This will lead to improved outcomes in adulthood. ..
- Strategies for ACE2 Amplification to Treat Diabetic Kidney DiseaseDaniel Batlle; Fiscal Year: 2010....
- REGULATION OF DEVELOPMENTAL RENAL HEMODYNAMICSMichael Solhaug; Fiscal Year: 1999..Highly activated renal vasoconstrictors, such as the renin angiotensin system and renal sympathetic nerves are considered to maintain the unique conditions in the developing renal ..
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceROSARIO G SCALIA; Fiscal Year: 2010..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- ANGIOTENSIN II RECEPTOR SIGNALING DOMAINSR Alexander; Fiscal Year: 2004..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..