Genomes and Genes
renin angiotensin system
Summary: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Publications239 found, 100 shown here
- A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9M Donoghue
Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
Circ Res 87:E1-9. 2000..The full text of this article is available at http://www. circresaha.org...
- Renin-angiotensin system and cardiovascular riskRoland E Schmieder
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, 91054 Erlangen, Germany
Lancet 369:1208-19. 2007..Thus, blockade of this system will remain a cornerstone of our strategies to reduce cardiovascular risk...
- Renin-angiotensin system revisitedF Fyhrquist
Minerva Institute for Medical Research and Department of Internal Medicine, Helsinki University Central Hospital, Helsinki, Finland
J Intern Med 264:224-36. 2008..Great expectations are now generated by the introduction of renin inhibitors. Indeed, RAS regulates much more and diverse physiological functions than previously believed...
- Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular diseaseCarlos M Ferrario
Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Am J Cardiol 98:121-8. 2006....
- Weight loss and the renin-angiotensin-aldosterone systemStefan Engeli
Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
Hypertension 45:356-62. 2005..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
- The renin angiotensin system and the metabolic syndromeAnnette D de Kloet
Program in Neuroscience University of Cincinnati, Cincinnati, OH 45237, United States
Physiol Behav 100:525-34. 2010The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of cardiovascular function and hydromineral balance) has regained the spotlight for its potential roles in various aspects of the metabolic ..
- Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic ratsManuel Portero-Otin
Department of Experimental Medicine, Faculty of Medicine, University of Lleida IRBLLEIDA PCiTAL Parc Científic Agroalimentari de Lleida, 25008 Lleida, Spain
Biochem Biophys Res Commun 368:528-35. 2008b>Renin angiotensin system (RAS) worsens diabetic nephropathy (DN) by increasing oxidative stress...
- Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatmentsAaron J Trask
The Hypertension and Vascular Research Center, Wake Forest University Health Science Center, Winston Salem, North Carolina 27157, USA
Cardiovasc Drug Rev 25:162-74. 2007..This review encompasses the pharmacology of Ang-(1-7) and expounds upon the peptide's potential as a therapeutic agent against pathological processes both within and outside the cardiovascular continuum...
- Angiotensin-(1-7) and the renin-angiotensin systemRobson A S Santos
Department of Physiology and Biophysics, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Curr Opin Nephrol Hypertens 16:122-8. 2007..In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system...
- Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)Iwona Kucharewicz
Department of Pharmacodynamics, Medical Academy of Bialystok, Bialystok, Poland
Hypertension 40:774-9. 2002..Thus, the antithrombotic effect of renin-angiotensin system blockers involves Ang-(1-7)-evoked release of NO and prostacyclin...
- Aliskiren: renin inhibitor for hypertension managementJudy W M Cheng
Massachusetts College of Pharmacy and Health Sciences and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Clin Ther 30:31-47. 2008..Certain agents that modify the RAAS can control blood pressure and improve cardiovascular outcomes. Aliskiren is the first of a new class of antihypertensive agents known as renin inhibitors...
- Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patientsJ Redon
Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
Pharmacogenomics J 5:14-20. 2005..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan...
- New angiotensinsJasmina Varagic
The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Mol Med (Berl) 86:663-71. 2008..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
- Activation of a local renin angiotensin system in podocytes by glucoseRaghu V Durvasula
Univ of Washington School of Medicine, Division of Nephrology, Box 356521, Seattle, WA 98195, USA
Am J Physiol Renal Physiol 294:F830-9. 2008..Taken together, the resultant activation of a local renin angiotensin system by high glucose may promote progressive podocyte injury and loss in diabetic nephropathy.
- A common polymorphism in the renin angiotensin system is associated with differential outcome of antihypertensive pharmacotherapy prescribed to Brazilian older womenClayton F Moraes
Postgraduation Program Stricto Sensu in Gerontology, Catholic University of Brasilia UCB, Geriatrics Service, Hospital of the Catholic University of Brasília, Brasilia DF, Brazil
Clin Chim Acta 396:70-5. 2008..Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy...
- Interaction between the polymorphisms of the renin-angiotensin system in preeclampsiaIoanna Bouba
Genetics Unit, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45500, Ioannina, Greece
Eur J Obstet Gynecol Reprod Biol 110:8-11. 2003..In conclusion, we found an association between the angiotensinogen variant 235T and preeclampsia as well as an interaction between the variant 235T and the two other genes studied...
- Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathyTadashi Konoshita
Third Department of Internal Medicine, Fukui University School of Medicine, Matsuoka, Fukui 910 1193, Japan
Diabetes Care 29:848-52. 2006..The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method...
- Myocardial infarction increases ACE2 expression in rat and humansLouise M Burrell
Department of Medicine, University of Melbourne, Austin Health, Repatriation Heidelberg Hospital, Heidelberg 3081, Victoria, Australia
Eur Heart J 26:369-75; discussion 322-4. 2005..We studied the expression of ACE2 after myocardial infarction (MI) in the rat as well as in human failing hearts...
- Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuriaMahmut Ilker Yilmaz
Department of Nephrology, Gulhane School of Medicine, Etlik Ankara, Turkey
Clin J Am Soc Nephrol 4:535-41. 2009..Moreover, PTX3 has been suggested to represent a novel mortality risk factor, and elevated PTX3 levels have been shown to accompany increased albuminuria among patients with chronic kidney disease (CKD)...
- The renin angiotensin system and Alzheimer's diseaseP Amouyel
INSERM U508, Institut Pasteur de Lille, France
Ann N Y Acad Sci 903:437-41. 2000..As a major player of vascular homeostasis, the renin angiotensin system (RAS) proteins constitute an interesting source of candidate genes...
- Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophyY Sakata
Department of Internal Medicine and Therapeutics, Osaka University, Osaka University Graduate School of Medicine, Suita, Japan
J Am Coll Cardiol 37:293-9. 2001OBJECTIVES: This study aimed to characterize the difference between renin angiotensin system (RAS)-dependent and RAS-independent hypertrophy and their differential contribution to the transition to heart failure...
- Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptorAlan Daugherty
Division of Cardiovascular Medicine, Wethington Building, Room 521, University of Kentucky, Lexington, KY 40536 0200, USA
Circulation 110:3849-57. 2004..We hypothesized that hypercholesterolemia stimulates the production of angiotensin peptides to provide a rationale for the profound effect of AT1A receptor deficiency on atherogenesis...
- Origin of aldosterone in the rat heartElise P Gomez-Sanchez
Research Service, G V Sonny Montgomery Veterans Affairs Medical Center, 1500 East Woodrow Wilson Drive 151, Jackson, Mississippi 39216, USA
Endocrinology 145:4796-802. 2004..In conclusion, we found that the level of aldosterone content in the healthy rat heart in vivo is significantly lower than that reported elsewhere and reflects plasma levels in intact rats...
- Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAALDick de Zeeuw
Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
Kidney Int 65:2309-20. 2004....
- Renin-angiotensin-aldosterone system and G-protein beta-3 subunit gene polymorphisms in salt-sensitive essential hypertensionE Pamies-Andreu
Unidad de Hipertensión Arterial y Lípidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
J Hum Hypertens 17:187-91. 2003..Although there is no association between salt sensitivity and the different studied genotypes of the RAAS and of the GNB3, our data show a greater risk for salt sensitivity among carriers of the W allele of the CYP11B2 1C polymorphism...
- Renin angiotensin system and gender differences in the cardiovascular systemMarcus Fischer
Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Cardiovasc Res 53:672-7. 2002....
- Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal diseaseRegina Kunz
Basel Institute for Clinical Epidemiology and Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland
Ann Intern Med 148:30-48. 2008..Reports suggest that angiotensin-receptor blockers (ARBs) reduce proteinuria, but results are variable. The relative effect of ARBs and angiotensin-converting enzyme (ACE) inhibitors, and their combined administration, remains uncertain...
- Renin angiotensin system polymorphisms in patients with metabolic syndrome (MetS)Lucia Maria Procopciuc
Department of Medical Biochemistry, Iuliu Hatieganu University of Medicine and Pharmacy, 8 14 Padis Street, Cluj Napoca, Romania
Eur J Intern Med 21:414-8. 2010..The genes associated with hypertension could be genetic risk factors for metabolic syndrome (MetS)...
- The renin-angiotensin system and diabetic nephropathySusan B Gurley
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC 27705, USA
Semin Nephrol 27:144-52. 2007..We provide a general review of the RAS and its role in diabetic nephropathy...
- Intrarenal activation of renin angiotensin system in the development of cyclosporine A induced chronic nephrotoxicityMing hua Shang
Department of Nephrology, First People s Hospital, Shanghai Jiaotong University, Shanghai, China
Chin Med J (Engl) 121:983-8. 2008..This study was conducted to detect the levels of renin and angiotensin II (ANGII) both in renal tissue and plasma from kidney transplantation patients suffering from CAN...
- Changes in the renin angiotensin system during the development of colorectal cancer liver metastasesJaclyn H Neo
Department of Surgery, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
BMC Cancer 10:134. 2010Blockade of the renin angiotensin system (RAS) via angiotensin I converting enzyme (ACE) inhibition reduces growth of colorectal cancer (CRC) liver metastases in a mouse model...
- Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston studyIhab Hajjar
Harvard Medical School, Institute for Aging Research Hebrew SeniorLife Beth Israel Deaconess Medical Center, Division of Gerontology, Boston, MA 02130, USA
Stroke 41:635-40. 2010Our objective was to investigate the associations between polymorphisms in representative genes of the renin angiotensin system with measures of cerebral blood flow regulation in older adults.
- Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratioShigeyuki Wakahara
Third Department of Internal Medicine, Fukui University School of Medicine, 23 3, Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
Endocrinology 148:2453-7. 2007..Thus, ACE2 may exert pivotal effects on cardiovascular and renal conditions...
- The expanding role of oxidative stress, renin angiotensin system, and beta-cell dysfunction in the cardiometabolic syndrome and Type 2 diabetes mellitusGuido Lastra
Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA
Antioxid Redox Signal 9:943-54. 2007..Hyperglycemia, elevated circulating fatty acids, inadequate local activation of renin angiotensin system, and chronic low grade inflammation are conditions that coexist in the CMS and DM2 that turn out to be ..
- Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) studyC E Mogensen
Department of Medicine, M, Kommunehospitalet, University Hospital, DK 8000 Aarhus C, Denmark
BMJ 321:1440-4. 2000..To assess and compare the effects of candesartan or lisinopril, or both, on blood pressure and urinary albumin excretion in patients with microalbuminuria, hypertension, and type 2 diabetes...
- Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertensionMasato Furuhashi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
Hypertension 42:76-81. 2003..These results suggest that hypoadiponectinemia is related to insulin resistance in essential hypertension and that RAS blockade increases adiponectin concentrations with improvement in insulin sensitivity...
- Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic isletsT Lau
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
Diabetologia 47:240-8. 2004..The increased expression of the AT1-receptor in islet transplants could have relevance to islet-graft function...
- Angiotensin II receptor antagonistsM Burnier
Department of Medicine, Centre Hospitalier Universitaire, Lausanne, Switzerland
Lancet 355:637-45. 2000..Trials now underway will demonstrate whether angiotensin II receptor antagonists can prevent target-organ damage and reduce cardiovascular morbidity and mortality. If they do, these compounds might one day replace ACE inhibitors...
- Managing cardiovascular and renal risk: the potential of direct renin inhibitionPeter S Sever
International Centre for Circulatory Health, Imperial College London, UK
J Renin Angiotensin Aldosterone Syst 10:65-76. 2009..In this article, we review the antihypertensive efficacy of aliskiren and explore its potential in the management of cardiovascular and renal risk...
- Inflammation in hypertensionCarmine Savoia
Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
Curr Opin Nephrol Hypertens 15:152-8. 2006..The identification of the mechanisms leading to the activation of inflammation should contribute to the development of specific therapeutic approaches to apply in hypertension and its complications...
- The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic conditionS P Ip
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
J Mol Endocrinol 31:563-71. 2003..The significance of its reversibility and adaptability following chronic hypoxia may be of physiological relevance to the pancreas...
- Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patientsBedia Agachan
University of Istanbul, Institute of Experimental Medical Research, Department of Molecular Medicine, Istanbul, Turkey
Exp Mol Med 35:545-9. 2003..As there are no existing data for the Turkish population, we investigated four Renin Angiotensin System (RAS) gene polymorphisms, the angiotensin converting enzyme (ACE), angiotensinogen (AGN) M235T/T174M and ..
- Pleiotropic effects of angiotensin II receptor blocker in hypertensive patientsKwang Kon Koh
Department of Cardiology, Vascular Medicine and Atherosclerosis Unit, Gil Heart Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, Korea 405 760
J Am Coll Cardiol 42:905-10. 2003..We investigated the vascular effects of candesartan in hypertensive patients...
- Renin release in response to Renin system blockade: activation of the Renin system in type 1 diabetes mellitusRadomir D Stevanovic
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Renin Angiotensin Aldosterone Syst 6:78-83. 2005..1+/-17.6 ml/minute/1.73 m2). When it was above the median, the RPF response was also larger (62.2+/-13.9 ml/minute/1.73 m2; p=0.006). Renin response to ACE-I and ARB confirms activation of the RAS in diabetic patients...
- Renin-angiotensin system and atherothrombotic disease: from genes to treatmentDouglas S Jacoby
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, 3400 Spruce Street, Philadelphia, PA 19104, USA
Arch Intern Med 163:1155-64. 2003..This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials...
- The renin-angiotensin-aldosterone system: a pivotal role in insulin sensitivity and glycemic controlJennifer M Perkins
Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University, Nashville, Tennesse 37232 0475, USA
Curr Opin Endocrinol Diabetes Obes 15:147-52. 2008....
- Angiotensin II receptor blockade: is there truly a benefit of adding an ACE inhibitor?Andrei Forclaz
Division of Hypertensive and Vascular Medicine, University Hospital of Lausanne, Switzerland
Hypertension 41:31-6. 2003..A 24-hour blockade can be achieved with an angiotensin antagonist alone, provided higher doses or a BID regimen is used...
- Blood pressure reduction is not the only determinant of outcomePeter S Sever
International Centre for Circulatory Health, Imperial College London, 59 N. Wharf Rd, London, W2 1PG, UK
Circulation 113:2754-72; discussion 2773-4. 2006
- ACE2, a new regulator of the renin-angiotensin systemLouise M Burrell
Department of Medicine, University of Melbourne, Austin Health, Heidelberg Heights 3081, Australia
Trends Endocrinol Metab 15:166-9. 2004..ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function...
- Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?Mark C Chappell
Hypertension and Vascular Disease Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27015, USA
Hypertension 50:596-9. 2007
- Localisation of renin-angiotensin system (RAS) components in breastM Tahmasebi
School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK
Br J Cancer 95:67-74. 2006..3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer...
- Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitusCharlie Zhao
Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07932
Clin Pharmacokinet 45:1125-34. 2006..This study compared the pharmacokinetics and pharmacodynamics of the orally active direct renin inhibitor, aliskiren, in healthy volunteers and patients with type 2 diabetes...
- Genetics of human hypertensionAnupam Agarwal
Harvard Medical School and Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Trends Endocrinol Metab 16:127-33. 2005....
- Prevention of new-onset atrial fibrillation and its predictors with angiotensin II-receptor blockers in the treatment of hypertension and heart failureTonje A Aksnes
Department of Cardiology, Ullevaal University Hospital, N 0407 Oslo, Norway
J Hypertens 25:15-23. 2007..This review aims to consider the preventive effect of ARBs on new-onset atrial fibrillation observed in recent reports from these trials, and to discuss possible mechanisms of the beneficial effect of angiotensin II-receptor blockade...
- Angiotensinogen and plasminogen activator inhibitor-1 gene polymorphism in relation to chronic allograft dysfunctionKadriye Reis
Department of Nephrology, Gazi University, Ankara, Turkey
Clin Transplant 19:10-4. 2005..001 and <0.05). Determination of AGT M235T and PAI-1 genotypes prior to transplantation may help identify patients who at risk for chronic renal transplant dysfunction...
- Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studiesArlene B Chapman
Emory University School of Medicine, 1364 Clifton Road, Room GG23, Atlanta, GA 30322, USA
Clin J Am Soc Nephrol 3:1197-204. 2008..Findings from CRISP and the rationale for interventions in ADPKD are described, and the design of the HALT-PKD clinical trial is outlined...
- The potential role of prorenin in diabetic nephropathyRoland E Schmieder
Department of Nephrology and Hypertension, , Germany
J Hypertens 25:1323-6. 2007
- Targeting mechanisms of hypertensive vascular disease with dual calcium channel and renin-angiotensin system blockadeM R Weir
Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA
J Hum Hypertens 21:770-9. 2007....
- Genetic polymorphisms of the renin-angiotensin system in end-stage renal diseaseMonika Buraczynska
Laboratory for Molecular Diagnostics of Multifactorial Diseases, Department of Nephrology, University Medical School, Dr K Jaczewskiego 8, 20 954 Lublin, Poland
Nephrol Dial Transplant 21:979-83. 2006..We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients...
- Intravenous delivery of PTH/PTHrP type 1 receptor cDNA to rats decreases heart rate, blood pressure, renal tone, renin angiotensin system, and stress-induced cardiovascular responsesSamuel Fritsch
Renovascular Pharmacology and Physiology (INSERM, University of Louis Pasteur School of Medicine, Strasbourg, France
J Am Soc Nephrol 15:2588-600. 2004..In addition, these results revealed that PTH1R-mediated mechanisms might have protective effects against cardiovascular stress-induced responses, including stimulations in heart rate and RAS...
- Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin systemDae Gil Kang
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Korea
Am J Chin Med 30:87-93. 2002..These results suggest that danshen has an anti-hypertensive effect through the inhibition of ACE, an essential regulatory enzyme of RAS...
- Effects of eprosartan versus hydrochlorothiazide on markers of vascular oxidation and inflammation and blood pressure (renin-angiotensin system antagonists, oxidation, and inflammation)Syed T Rahman
Emory University School of Medicine, Division of Cardiology, Atlanta, Georgia 30303, USA
Am J Cardiol 89:686-90. 2002....
- Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal diseaseA Boonstra
Department of Medicine, Division of Nephrology, University Hospital, Groningen, The Netherlands
Semin Nephrol 21:580-92. 2001..Such information is vital, not only to make sense of observed associations, but all the more so if one wants to apply the insights on the role of genetic factors into better strategies for disease intervention...
- Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsiaFlorian Herse
Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum, Berlin, Germany
Hypertension 49:604-11. 2007..We also showed that AT1 autoantibodies cross the ureteroplacental barrier. These components could participate in the pathophysiology of preeclampsia...
- Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal diseaseE Lovati
Division of Nephrology and Hypertension, Inselspital, University of Berne, Berne, Switzerland
Kidney Int 60:46-54. 2001..Genes encoding for angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and aldosterone synthase (CYP11B2) are candidates for abnormal blood pressure regulation...
- Effects of circadian rhythms, posture, and medication on renin-aldosterone interrelations in essential hypertensivesMaxime Lamarre-Cliche
Institut de recherches cliniques de Montreal IRCM, Canada
Am J Hypertens 18:56-64. 2005..This study, part of a clinical trial, was designed to measure the influence of circadian rhythms, antihypertensive drugs, and body posture on plasma renin, on aldosterone, and on their interrelation...
- Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 ratsJewell A Jessup
Hypertension and Vascular Disease Center, Wake Forest Univ. School of Medicine, Winston-Salem, NC 27157, USA
Am J Physiol Heart Circ Physiol 291:H2166-72. 2006..Tg(mRen2) congenic rats, a failure of compensatory ACE2 and ANG-(1-7)-dependent vasodepressor mechanisms may contribute both to the development and progression of hypertension driven by increased formation of endogenous ANG II...
- Development of inhibitors of the aspartyl protease renin for the treatment of hypertensionBoyd B Scott
Vitae Pharmaceuticals, Discovery Biology, 502 West Office Center Dr Ft Washington, PA 19034, USA
Curr Protein Pept Sci 7:241-54. 2006..Finally we will discuss what might distinguish renin inhibitors from current therapeutic options and discuss other therapeutic indications renin inhibitors might have...
- Estrogen and salt sensitivity in the female mRen(2). Lewis ratMark C Chappell
Hypertension and Vascular Disease Center, Wake Forest Univ Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157 1095, USA
Am J Physiol Regul Integr Comp Physiol 291:R1557-63. 2006....
- Inhibiting the renin-angiotensin system to prevent cardiovascular diseases: do we need a more comprehensive strategy?Michael A Weber
State University of New York Downstate Medical Center, Brooklyn, NY, USA
Rev Cardiovasc Med 7:45-54. 2006....
- Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-systemI Gammelgaard
Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, Odense, Denmark
Acta Physiol (Oxf) 188:129-38. 2006..The metabolic clearance rate of AngIII is five times that of AngII...
- Novel therapies blocking the renin-angiotensin-aldosterone system in the management of hypertension and related disordersHenry Krum
NHMRC Centre of Clinical Excellence in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University Alfred Hospital, Central and Eastern Clinical School, Melbourne, Victoria 3004, Australia
J Hypertens 25:25-35. 2007..Finally, ACE2 augmentation, antisense gene strategies, and vaccination against the renin-angiotensin system should still be considered experimental, but have significant appeal as additional approaches to the blockade of this system...
- A vaccine for hypertensionJoël Ménard
J Hypertens 25:41-6. 2007
- Role of the renin-angiotensin-aldosterone system in vascular remodeling and inflammation: a clinical reviewDaniel A Duprez
Cardiovascular Division, Medical School, University of Minnesota, Minneapolis 55455, USA
J Hypertens 24:983-91. 2006..Understanding the molecular and cellular mechanisms that participate in the early development of hypertensive vascular disease may lead to more targeted treatment and improved outcomes...
- Decreased angiotensin II receptors in subfornical organ of spontaneously hypertensive rats after chronic antihypertensive treatment with enalaprilA J Nazarali
Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892
Am J Hypertens 3:59-61. 1990..Selective decrease of ANG II receptors in the SFO of the genetically hypertensive rats with enalapril may be related to its therapeutic efficacy...
- The pathophysiologic basis for blocking the renin-angiotensin system in hypertensive patients with renal diseaseLeopoldo Raij
Renal Hypertension Division, University of Miami, Miami, Florida 33125 1624, USA
Am J Hypertens 18:95S-99S. 2005..Emerging data from experimental and clinical studies may lead to improvements in therapeutic efforts to prevent or slow the progression of renal disease...
- [Angiotensin II receptor blockers--evidence along the cardiovascular continuum]A Zeller
Praxis (Bern 1994) 94:581-94. 2005....
- Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive ratsMarcio A F de Godoy
Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College of Thomas Jefferson University, 1025 Walnut St, Room 901 College Philadelphia, PA 19107, USA
J Pharmacol Exp Ther 318:725-34. 2006....
- Effects of captopril on the renin angiotensin system, oxidative stress, and endothelin in normal and hypertensive ratsRodney J Bolterman
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Hypertension 46:943-7. 2005....
- Effects of dual blockade of the renin angiotensin system in hypertensive type 2 diabetic patients with nephropathyJ P S Matos
Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, Rio de Janeiro State University, Rio de Janeiro, Brazil
Clin Nephrol 64:180-9. 2005..05) and Per + Irb (-36%, p < 0.05) but not with Per (-11%, p = 0.60). CONCLUSION: Only combined therapy with irbesartan plus perindopril concurrently reduces plasma aldosterone, proteinuria and urinary TGF-beta1...
- Sustained 24-hour blockade of the renin-angiotensin system: a high dose of a long-acting blocker is as effective as a lower dose combined with an angiotensin-converting enzyme inhibitorChristopher Hasler
, Centre Hospitalier Universitaire Vaudois
Clin Pharmacol Ther 78:501-7. 2005..Hence, a higher dose of a long-acting ARB is as effective as a lower dose of the same compound combined with an angiotensin-converting enzyme inhibitor in terms of blockade of the vascular effects of angiotensin...
- Role of angiotensin II in the evolution of diastolic heart failureKavitha M Chinnaiyan
Division of Cardiology and Nutrition, William Beaumont Hospital, Royal Oak, MI 48073, USA
J Clin Hypertens (Greenwich) 7:740-7. 2005....
- Pharmacogenetics of antihypertensive treatmentDonna K Arnett
Department of Epidemiology, University of Alabama, RPHB 220E, 1530 3rd Avenue South, Birmingham, 55294 0022, USA
Vascul Pharmacol 44:107-18. 2006..Caution regarding the future of hypertension pharmacogenetics is warranted...
- Renin inhibition with aliskiren: where are we now, and where are we going?Michel Azizi
Clinical Investigation Center 9201, Hospital European Georges Pompidou, Paris, France
J Hypertens 24:243-56. 2006..The relevant and necessary studies are ongoing...
- Evolution and hypertension: is the Renin system necessary?Haralambos Gavras
Hypertension 49:e36; author reply e37. 2007
- The renin system: is direct renin inhibition different from blockade at the AT1 receptor or the ACE step?Norman K Hollenberg
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Rev Cardiovasc Med 8:S7-13. 2007..For many patients, this is likely to lead to improved treatment...
- Hyperinsulinemic rats are normotensive but sensitized to angiotensin IIMaria E Johansson
Department of Molecular and Clinical Medicine Clinical Physiology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Am J Physiol Regul Integr Comp Physiol 294:R1240-7. 2008..Moreover, we found no evidence that insulin affects sympathetic nervous system activity. However, chronic losartan treatment revealed an important interaction between insulin and RAAS in BP control...
- The renin inhibitor aliskiren as novel treatment for cardiovascular diseaseAnabelle O Saez
Department of Nephrology and Hypertension, University Hospital Essen, Germany
Recent Patents Cardiovasc Drug Discov 1:233-40. 2006..Aliskiren is effective in animal models, while recent results from studies in humans indicate that aliskiren is the first in a new class of orally effective renin inhibitors for the treatment of hypertension...
- Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix productionVivek P Singh
Cardiovascular Research Institute, Texas A and M HSC, Temple, TX 76504, USA
Am J Physiol Heart Circ Physiol 294:H1675-84. 2008....
- Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysisSteven G Chrysant
University of Oklahoma, Oklahoma City, OK 73132, USA
Curr Med Res Opin 24:1039-47. 2008..Here we report the results of a pre-planned 6-month interim analysis of a long-term, open-label study examining the safety, tolerability and efficacy of the aliskiren/valsartan 300/320-mg combination in patients with hypertension...
- The antihypertensive mechanism of delapril, a newly developed converting enzyme inhibitor, is related to the suppression of vascular angiotensin II release in the spontaneously hypertensive ratK Mizuno
Third Department of Internal Medicine, Fukushima Medical College, Japan
Am J Hypertens 4:60S-66S. 1991..These results suggest the presence of a functional RAS in vascular tissues, and that delapril exerts its antihypertensive effect through inhibition of vascular Ang II release in SHRs...
- Recent update in the management of hypertensionSalim Lim
Department of Internal Medicine, Husada Hospital, Jakarta, Indonesia
Acta Med Indones 39:186-91. 2007..Patients with proteinuria > 1 g/day despite optimal BP control with angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) monotherapy may benefit from a combination therapy...
- Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis ratsKarl D Pendergrass
Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
Am J Physiol Heart Circ Physiol 295:H10-20. 2008..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain...
- [spACE, the last frontier? Renin inhibition in hypertension]Luigi Villa
Struttura Complessa di Nefrologia, Dialisi e Trapianto, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
G Ital Nefrol 25:274. 2008
- Salt-sensitive hypertension resulting from nitric oxide synthase inhibition is associated with loss of regulation of angiotensin II in the ratG Hodge
Hypertension Service, South Western Sydney Area Health Service, The Bankstown-Lidcombe Hospital, Locked Mail Bag 1600, Eldridge Road, Bankstown, NSW 2200, Australia
Exp Physiol 87:1-8. 2002..Further, the salt-sensitive component appears to be Ang II-dependent, as it was associated with increasing plasma Ang II levels and could be reversed by treatment with an Ang II receptor antagonist...
- Pathophysiology of target-organ disease: does angiotensin II remain the key?Ronald G Victor
Hypertension Division, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8586, USA
J Clin Hypertens (Greenwich) 9:4-10. 2007..New outcomes trials are under way to explore the full potential of more complete RAS blockade with regard to cardiovascular target-organ protection...
- [Nonmodulating hypertension]Masataka Iwane
Wakayama Wellness Foundation
Nippon Rinsho . 2007
- Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR(mRen-2)27 by angiotensin converting enzyme inhibitionY Tokita
Department of Medicine, Medical College of Ohio, Toledo, USA
Am J Hypertens 8:1031-9. 1995..The low kidney renin appears to be due to physiological rather than genetic factors...
- Renin inhibition: a new modality for hypertension managementHelmy M Siragy
Division of Endocrinology and Metabolism, Department of Medicine, PO Box 801409, University of Virginia Health System, Charlottesville, VA 22908 1409, USA
Curr Hypertens Rep 9:291-4. 2007..Studies are in progress to evaluate the potential role for renin inhibition in management of kidney and cardiac diseases...
- Direct inhibition of renin as a cardiovascular pharmacotherapy: focus on aliskirenReza Sepehrdad
Department of Internal Medicine, UC Davis Medical Center, Sacramento, California, USA
Cardiol Rev 15:242-56. 2007....
- Novel drugs targeting hypertension: renin inhibitorsA H Jan Danser
Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
J Cardiovasc Pharmacol 50:105-11. 2007..The review ends with a brief overview of the available (pre)clinical aliskiren data and a description of its safety profile...
- Role of the Renin-Angiotensin System in the Regulation of Biliary ProliferationShannon Glaser; Fiscal Year: 2009....
- Fibrotic Sequelae of Childhood Renal DiseaseAgnes Fogo; Fiscal Year: 2007..Mol Cell 3:1-10, 1999. Nishimura H, Ichikawa I: What have we learned from gene targeting studies for the renin angiotensin system of the kidney? Intern Med, 38:315-323,1999...
- RENIN/ANGIOTENSIN SYSTEM AND FIBRINOLYSIS IN HUMANSDouglas Vaughan; Fiscal Year: 2001....
- Insulin action in human cardiac and skeletal muscle microvasculatureZhenqi Liu; Fiscal Year: 2010....
- Role of the renin-angiotensin system in sexual dimorphisms in the development ofJennifer C Sullivan; Fiscal Year: 2010....
- Targeted Overexpression and Ablation of Renin in Connecting TubuleJean Marc Lalouel; Fiscal Year: 2007..The work should advance diagnosis and treatment of hypertension. ..
- Central actions of angiotensin II in the control of fluid balanceDANIEL K contact YEE; Fiscal Year: 2010..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Central actions of angiotensin II in the control of fluid balanceLORI MARIE FLANAGAN CATO; Fiscal Year: 2011..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Central actions of angiotensin II in the control of fluid balanceDaniel Yee; Fiscal Year: 2009..Thus, an understanding of this behavior has important ramifications with respect to the development of hypertension and cardiovascular disease. ..
- Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic StrokeYanfang Chen; Fiscal Year: 2010..The results of this project will provide new insights on the role of Ang II/Ang (1-7) balance in the pathophysiology of ischemic stroke, and thus facilitate the development of novel therapeutic targets for ischemic stroke. ..
- Role of the Renin-Angiotensin System in the Regulation of Biliary ProliferationSHANNON STROUD GLASER; Fiscal Year: 2010....
- Crystal Associated Renal Inflammation and Treatment OptionsSaeed R Khan; Fiscal Year: 2010....
- Vitamin D: A Negative Regulator of Renin ExpressionYan Chun Li; Fiscal Year: 2003..abstract_text> ..
- ROLE OF GLUCOSE IN hAT1 GENE EXPRESSIONThomas Thekkumkara; Fiscal Year: 2007..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
- ROLE OF GLUCOSE IN hAT1 GENE EXPRESSIONThomas Thekkumkara; Fiscal Year: 2009..therapy is broadly effective in patients with diabetic nephropathy suggesting an important role for renin angiotensin system in the progression of this disorder...
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceRosario Scalia; Fiscal Year: 2009..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceROSARIO G SCALIA; Fiscal Year: 2010..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROMEJulie Ingelfinger; Fiscal Year: 2004..It is anticipated that specific blockade may lead to strategies with clinical relevance for the possible prevention or amelioration of HUS. ..
- Angiotensin: A Link Between Obesity and HypertensionLisa Cassis; Fiscal Year: 2007..The goals of this research are to definitively determine the role of adipose-derived angiotensins and the systemic renin-angiotensin system in blood pressure elevations in diet-induced obesity. ..
- Intercellular Signaling in Obstructive NephropathyROBERT CHEVALIER; Fiscal Year: 2005..This will lead to improved outcomes in adulthood. ..
- Strategies for ACE2 Amplification to Treat Diabetic Kidney DiseaseDaniel Batlle; Fiscal Year: 2010....
- REGULATION OF DEVELOPMENTAL RENAL HEMODYNAMICSMichael Solhaug; Fiscal Year: 1999..Highly activated renal vasoconstrictors, such as the renin angiotensin system and renal sympathetic nerves are considered to maintain the unique conditions in the developing renal ..
- In Vivo Mechanisms of Vascular Dysfunction in Obesity with Insulin ResistanceROSARIO G SCALIA; Fiscal Year: 2010..We expect that the results of our research will improve life quality and expectancy of the obese, insulin resistant U.S. population, in addition to lowering the overall economic cost of managing cardiovascular disease. ..
- ANGIOTENSIN II RECEPTOR SIGNALING DOMAINSR Alexander; Fiscal Year: 2004..Insights gained in understanding of the mechanisms of Ang II signaling will lead to increased understanding of the pathogenesis and potential treatment of hypertension and atherosclerosis. ..