lipolysis

Summary

Summary: The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.

Top Publications

  1. ncbi Lipid droplets in lipogenesis and lipolysis
    Nicole A Ducharme
    Center for Diabetes and Obesity Research, Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Endocrinology 149:942-9. 2008
  2. pmc FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    Partha Chakrabarti
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:13296-300. 2009
  3. pmc Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
    Partha Chakrabarti
    Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 59:775-81. 2010
  4. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
  5. ncbi Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    Hongfei Ge
    Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Endocrinology 149:4519-26. 2008
  6. pmc Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    Aliki Kosteli
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3466-79. 2010
  7. pmc FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    Cell Metab 15:279-91. 2012
  8. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
  9. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008
  10. pmc Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    Prog Lipid Res 50:14-27. 2011

Detail Information

Publications273 found, 100 shown here

  1. ncbi Lipid droplets in lipogenesis and lipolysis
    Nicole A Ducharme
    Center for Diabetes and Obesity Research, Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Endocrinology 149:942-9. 2008
    ..regulator [Comparative Gene Identification-58 (CGI-58)], which has led to reconsideration of the decades-old model of lipolysis. Future discovery likely will be driven by the exploitation of model organisms and by human genetic studies.
  2. pmc FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes
    Partha Chakrabarti
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:13296-300. 2009
    ..of FoxO1 in 3T3-L1 adipocytes decreases the expression of ATGL and attenuates basal and isoproterenol-stimulated lipolysis. Infection of mouse embryonic fibroblasts with FoxO1-encoding lentivirus increases ATGL expression and renders ..
  3. pmc Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
    Partha Chakrabarti
    Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 59:775-81. 2010
    ..In metazoans, target of rapamycin complex 1 (TORC1) plays the key role in nutrient- and hormone-dependent control of metabolism. However, the role of TORC1 in regulation of triglyceride storage and metabolism remains largely unknown...
  4. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
    Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance...
  5. ncbi Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids
    Hongfei Ge
    Amgen Inc, 1120 Veterans Boulevard, South San Francisco, California 94080, USA
    Endocrinology 149:4519-26. 2008
    ..This inhibition of lipolysis is the result of GPR43 activation, because this effect is abolished in adipocytes isolated from GPR43 knockout ..
  6. pmc Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    Aliki Kosteli
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3466-79. 2010
    ..the response of adipose tissue macrophages (ATMs) to weight loss and fasting in mice and identified a role for lipolysis in ATM recruitment and accumulation...
  7. pmc FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    Cell Metab 15:279-91. 2012
    b>Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets...
  8. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
    ..Perilipin serves important functions in the regulation of basal and hormonally stimulated lipolysis. Under basal conditions, perilipin restricts the access of cytosolic lipases to lipid droplets and thus promotes ..
  9. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008
    ..These phenotypes are conserved in mammalian cells, suggesting that insights from these studies are likely to be central to our understanding of human diseases involving excessive lipid storage...
  10. pmc Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    Prog Lipid Res 50:14-27. 2011
    b>Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG) stored in cellular lipid droplets...
  11. ncbi Lipolysis and lipid mobilization in human adipose tissue
    Max Lafontan
    INSERM U, Institut de Medecine Moleculaire de Rangueil, IFR BMT, Toulouse, France
    Prog Lipid Res 48:275-97. 2009
    ..triglyceride lipase/desnutrin (ATGL) has been identified as playing an important role in the control of fat cell lipolysis. Additionally perilipin and other proteins of the surface of the lipid droplets protecting or exposing the TAG ..
  12. ncbi Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    Sung Hee Um
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 431:200-5. 2004
    ..Thus under conditions of nutrient satiation S6K1 negatively regulates insulin signalling...
  13. pmc Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California Berkeley, CA 94720, USA
    Cell Metab 13:739-48. 2011
    While fatty acids (FAs) released by white adipose tissue (WAT) provide energy for other organs, lipolysis is also critical in brown adipose tissue (BAT), generating FAs for oxidation and UCP-1 activation for thermogenesis...
  14. pmc Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    Wei Chen
    Department of Geriatrics, Hua Shan Hospital, Fudan University, Shanghai 200040, China
    J Biol Chem 286:34559-66. 2011
    ..Both hormones are induced in response to fasting and exert their actions on adipocytes to regulate lipolysis. However, the molecular interaction between these two hormones remains unclear...
  15. ncbi Interleukin-6 stimulates lipolysis and fat oxidation in humans
    Gerrit van Hall
    Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:3005-10. 2003
    ..In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia...
  16. ncbi Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
    ..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL...
  17. ncbi The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis
    Antonis D Lampidonis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 157 84 Athens, Greece
    Gene 477:1-11. 2011
    ..Adipose tissue lipolysis is a catabolic process leading to the breakdown of triacylglycerols stored in fat cells, and release of fatty ..
  18. pmc The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    Xingyuan Yang
    Department of Pediatrics, University of Kentucky, Lexington, USA
    Cell Metab 11:194-205. 2010
    ..Knockdown of endogenous G0S2 accelerates basal and stimulated lipolysis in adipocytes, whereas overexpression of G0S2 diminishes the rate of lipolysis in both adipocytes and adipose ..
  19. ncbi Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C418B, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 56:2759-65. 2007
    ..The objective of this study is to quantitate expression of genes possibly contributing to insulin resistance and fat deposition in the human liver...
  20. ncbi Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    Yuhei Hotta
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Endocrinology 150:4625-33. 2009
    ..or knockdown mice and high-fat, low-carbohydrate ketogenic diet-fed mice suggests that Fgf21 stimulates lipolysis in the white adipose tissue during normal feeding and is required for ketogenesis and triglyceride clearance in ..
  21. pmc Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue
    Kathy Jaworski
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1-4. 2007
    ..tissue but also in other tissues such as liver for very-low-density lipoprotein formation, hydrolysis of TAG, lipolysis, predominantly occurs in adipose tissue...
  22. ncbi Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice
    J Martinez-Botas
    Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 26:474-9. 2000
    ..They are much leaner and more muscular than controls, have 62% smaller white adipocytes, show elevated basal lipolysis that is resistant to beta-adrenergic agonist stimulation, and are cold-sensitive except when fed...
  23. pmc Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis
    V L Albaugh
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Psychiatry 16:569-81. 2011
    ..had no effect on isoproterenol-stimulated rises in plasma glucose, it blunted isoproterenol-stimulated in vivo lipolysis in fed rats...
  24. pmc Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL
    Mandeep P Gaidhu
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Lipid Res 50:704-15. 2009
    ..b>Lipolysis was first suppressed, but then increased, both in vitro and in vivo, with prolonged AICAR treatment...
  25. pmc Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    Br J Cancer 86:424-8. 2002
    Induction of lipolysis in murine white adipocytes, and stimulation of adenylate cyclase in adipocyte plasma membranes, by a tumour-produced lipid mobilizing factor, was attenuated by low concentrations (10(-7)--10(-5)M) of the specific ..
  26. pmc Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis
    Jennifer Jager
    Institut National de la Sante et de la Recherche Medicale INSERM, U895, Mediterranean Center of Molecular Medicine, Team 7 Molecular and Cellular Physiopathology of Obesity and Diabetes, Nice, France
    Diabetes 59:61-70. 2010
    ..This study aims at identifying proteins regulating ERK1/2 activity, specifically in response to inflammatory cytokines, to provide new insights into mechanisms leading to abnormal adipose tissue function...
  27. pmc Liver X receptor (LXR) regulates human adipocyte lipolysis
    Britta M Stenson
    Department of Medicine, Karolinska Institutet, Huddinge, S 14186, Sweden
    J Biol Chem 286:370-9. 2011
    ..In contrast, the role of LXR in human adipocyte lipolysis, the major function of human white fat cells, is not clear...
  28. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
    b>Lipolysis is a critical metabolic pathway contributing to energy homeostasis through degradation of triacylglycerides stored in lipid droplets (LDs), releasing fatty acids. Neutral lipid lipases act at the oil/water interface...
  29. pmc Remodeling of lipid droplets during lipolysis and growth in adipocytes
    Margret Paar
    Institute of Molecular Biosciences, Lipidomics Research Center LRC Graz, University of Graz, 8010 Graz, Austria
    J Biol Chem 287:11164-73. 2012
    ..Time lapse fluorescence microscopy showed that stimulation of lipolysis in 3T3-L1 adipocytes causes progressive shrinkage and almost complete degradation of all cellular LDs but ..
  30. pmc Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    Chunbin Zhang
    Center for Molecular Medicine and Genetics, the Wayne State University School of Medicine, Detroit, MI 48201, USA
    Hepatology 55:1070-82. 2012
    ..we demonstrate that CREBH is a key metabolic regulator of hepatic lipogenesis, fatty acid (FA) oxidation, and lipolysis under metabolic stress...
  31. pmc Cytoplasmic receptor-interacting protein 140 (RIP140) interacts with perilipin to regulate lipolysis
    Ping Chih Ho
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Signal 23:1396-403. 2011
    ..cytoplasmic accumulation of RIP140, and a new functional role for cytoplasmic RIP140 in adipocyte to regulate lipolysis. Increased lipid content, particularly an elevation in diacylglycerol levels, promotes RIP140 cytoplasmic ..
  32. ncbi The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
    Kerstin Wahlen
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Lipid Res 49:607-11. 2008
    ..In contrast, there were no genotype effects on catecholamine-stimulated lipolysis or basal or insulin-induced lipogenesis...
  33. ncbi A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice
    Yan Yun Liu
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    J Biol Chem 278:38913-20. 2003
    Thyroid hormone has profound effects on metabolic homeostasis, regulating both lipogenesis and lipolysis, primarily by modulating adrenergic activity...
  34. pmc Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2
    Xin Lu
    Department of Pediatrics and the Kentucky Pediatric Research Institute, University of Kentucky, Lexington, KY, USA
    Cell Cycle 9:2719-25. 2010
    ..Adipose triglyceride lipase (ATGL) is the key enzyme for TAG hydrolysis (lipolysis) in adipocytes and LD degradation in nonadipocyte cells...
  35. pmc Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions
    Petra C Kienesberger
    Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
    J Lipid Res 50:S63-8. 2009
    ..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
  36. ncbi Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein
    Steven T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1636:59-68. 2004
    ..The aim of this study was to compare the ability of human ZAG with LMF to stimulate lipolysis in vitro and induce loss of body fat in vivo, and to determine the mechanisms involved...
  37. pmc Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
    James G Granneman
    Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 284:34538-44. 2009
    ..suggested that Abhd5, a protein activator of Atgl, coordinates with Plin in controlling basal and stimulated lipolysis; however, the underlying mechanism is controversial...
  38. pmc PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis
    Nabil Djouder
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 29:469-81. 2010
    ..These results suggest a new mechanism of negative regulation of AMPK activity by PKA that is important for converting a lipolytic signal into an effective lipolytic response...
  39. pmc Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
    Veronic Bezaire
    INSERM U858, Laboratoire de recherches sur les obésités, F 31432 Toulouse, France
    J Biol Chem 284:18282-91. 2009
    b>Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids...
  40. ncbi Quantitative modeling of triacylglycerol homeostasis in yeast--metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth
    Jürgen Zanghellini
    Institute of Chemistry, University of Graz, Austria
    FEBS J 275:5552-63. 2008
    ..We showed that, during pre-logarithmic growth, lipolysis of triacylglycerol allows for the rapid synthesis of membrane lipids, whereas de novo fatty acid synthesis plays ..
  41. pmc Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 284:32116-25. 2009
    b>Lipolysis is an important metabolic pathway controlling energy homeostasis through degradation of triglycerides stored in lipid droplets and release of fatty acids...
  42. ncbi Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis
    Yuki Tanaka
    Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Kidney Int 79:871-82. 2011
    ..we examined the role of peroxisome proliferator-activated receptor (PPAR)-α, a positive regulator of renal lipolysis. Feeding mice a high-fat diet induced glomerular injury, and treating them with fenofibrate, a PPARα agonist, ..
  43. ncbi Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
    C Holm
    Department of Cell and Molecular Biology, Section for Molecular Signalling, Lund University, Lund, Sweden
    Biochem Soc Trans 31:1120-4. 2003
    ..In adipocytes, catecholamines stimulate lipolysis mainly through PKA (protein kinase A)-mediated phosphorylation of HSL and perilipin, a protein coating the lipid ..
  44. ncbi Several agents and pathways regulate lipolysis in adipocytes
    Valéria Ernestânia Chaves
    Department of Basic Sciences in Health, Federal University of Mato Grosso, Cuiaba, Mato Grosso, Brazil
    Biochimie 93:1631-40. 2011
    ..The classical pathway of lipolysis activation in adipocytes is cAMP-dependent...
  45. ncbi Resveratrol regulates lipolysis via adipose triglyceride lipase
    Arrate Lasa
    Department of Nutrition and Food Science, University of Pais Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain
    J Nutr Biochem 23:379-84. 2012
    Resveratrol has been reported to increase adrenaline-induced lipolysis in 3T3-L1 adipocytes. The general aim of the present work was to gain more insight concerning the effects of trans-resveratrol on lipid mobilization...
  46. pmc Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine
    Tracy J Horton
    Section of Nutrition, Dept of Pediatrics, Univ of Colorado Denver, Campus Box C225, 12700 East 19th Ave, Aurora, CO 80045, USA
    J Appl Physiol (1985) 107:200-10. 2009
    ..levels during metabolic perturbations, such as exercise or hypoglycemia, but similar rates of systemic lipolysis. This suggests women may be more sensitive to the lipolytic action of catecholamines, while maintaining similar ..
  47. ncbi Regulation of visceral and subcutaneous adipocyte lipolysis by acute AICAR-induced AMPK activation
    Nicole M Anthony
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Obesity (Silver Spring) 17:1312-7. 2009
    This study investigated the role of adenosine monophosphate-activated protein kinase (AMPK) in the regulation of lipolysis in visceral (VC) and subcutaneous (SC) rat adipocytes and the molecular mechanisms involved in this process...
  48. ncbi IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes
    Chenbo Ji
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing, China
    J Bioenerg Biomembr 43:367-75. 2011
    ..In this study, we determined the direct effect of IL-6 on lipolysis in adipocytes, and the effects of IL-6 on mitochondrial function were investigated...
  49. pmc AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
    Kathy Jaworski
    Department of Nutritional Science and Toxicology, 220 Morgan Hall, University of California, Berkeley, California 94720, USA
    Nat Med 15:159-68. 2009
    ..Whereas endocrine regulation of lipolysis has been extensively studied, autocrine and paracrine regulation is not well understood...
  50. pmc Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-α (TNF-α)-induced lipolysis in adipocytes
    Xingyuan Yang
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Biol Chem 286:40477-85. 2011
    TNF-α potently stimulates basal lipolysis in adipocytes, which may contribute to hyperlipidemia and peripheral insulin resistance in obesity...
  51. pmc Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes
    Nora E Gray
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720 3104, USA
    J Biol Chem 287:8444-56. 2012
    ..a secreted protein induced by fasting or glucocorticoid treatment, in modulating intracellular adipocyte lipolysis. Glucocorticoid receptor blockade prevented fasting-induced tissue Angptl4 expression and WAT TG hydrolysis in ..
  52. pmc Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis
    Wei Zhong
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, USA
    Am J Pathol 180:998-1007. 2012
    ..3-fold. These data demonstrate for the first time that adipose triglycerides due to alcohol-induced hyperlipolysis are reverse transported and deposited in the liver...
  53. pmc Adiponectin inhibits lipolysis in mouse adipocytes
    Liping Qiao
    Department of Pediatrics, University of California San Diego, La Jolla, California, USA
    Diabetes 60:1519-27. 2011
    ..Adiponectin is an adipocyte-derived hormone that sensitizes insulin and improves energy metabolism in tissues. This study was designed to investigate the direct regulatory effects of adiponectin on lipid metabolism in adipocytes...
  54. ncbi Periodontal disease and hypertriglyceridemia in Japanese subjects: potential association with enhanced lipolysis
    Hideo Nakarai
    Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    Metabolism 60:823-9. 2011
    ..These results suggest that periodontal infection, especially bacterial endotoxinemia, is associated with enhanced lipolysis and subsequent up-regulation of circulating TG in Japanese with midrange BMI.
  55. ncbi Effects of arecoline on adipogenesis, lipolysis, and glucose uptake of adipocytes-A possible role of betel-quid chewing in metabolic syndrome
    Hsin Fen Hsu
    Laboratory of Molecular Toxicology, Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan
    Toxicol Appl Pharmacol 245:370-7. 2010
    ..the effects of arecoline, a major alkaloid in areca nuts, on adipogenic differentiation (adipogenesis), lipolysis, and glucose uptake by fat cells...
  56. ncbi The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages
    Viswanathan Saraswathi
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Lipid Res 47:1406-15. 2006
    ..These data have important implications for the direct proatherogenic effects of VLDL on macrophage-driven atherosclerosis...
  57. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  58. ncbi Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A
    Youyan Zhang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 334:729-32. 2005
    ..HM74A, but not HM74, expressed in differentiated 3T3L1 adipocytes effectively mediated inhibition of lipolysis by niacin...
  59. ncbi Dynamics of lipid droplet-associated proteins during hormonally stimulated lipolysis in engineered adipocytes: stabilization and lipid droplet binding of adipocyte differentiation-related protein/adipophilin
    Danielle N Gross
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Mol Endocrinol 20:459-66. 2006
    ..is stored within lipid droplets, which are coated with the protein perilipin, which functions to regulate lipolysis by controlling lipase access to the droplet in a hormone-regulatable fashion...
  60. pmc Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance
    Ulrike Taschler
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 286:17467-77. 2011
    ..reduced plasma glycerol and triacylglycerol, as well as liver triacylglycerol levels indicative for impaired lipolysis. Despite a strong elevation of 2-AG levels, MGL-ko mice exhibit normal food intake, fat mass, and energy ..
  61. pmc Spatiotemporal regulation of early lipolytic signaling in adipocytes
    Sally Martin
    Division of Molecular Cell Biology, Institute for Molecular Bioscience, University of Queensland, Queensland 4072, Australia
    J Biol Chem 284:32097-107. 2009
    Hormone-sensitive lipase (HSL) is a key enzyme regulating the acute activation of lipolysis. HSL functionality is controlled by multiple phosphorylation events, which regulate its association with the surface of lipid droplets (LDs)...
  62. ncbi Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability
    Anna Foryst-Ludwig
    Center for Cardiovascular Research CCR Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Am J Physiol Heart Circ Physiol 301:H115-22. 2011
    ..In parallel, women exhibit enhanced exercise-mediated lipolysis compared with men, which might be linked to cardiac responses...
  63. ncbi Human fat cell lipolysis: biochemistry, regulation and clinical role
    Peter Arner
    Department of Medicine M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Best Pract Res Clin Endocrinol Metab 19:471-82. 2005
    Release of fatty acids (FAs) from adipose tissue through lipolysis in fat cells is a key event in many processes. FAs are not only energy substrates but also signalling molecules and substrates for lipoprotein production by the liver...
  64. pmc Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
    Melissa L Borg
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Diabetes 60:1458-66. 2011
    ..We used ATGL(-/-) mice to determine the role of PEDF in regulating lipid and glucose metabolism...
  65. ncbi Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham and Heartlands Hospital, Edgbaston, Birmingham, UK
    Diabetes 51:1493-8. 2002
    b>Lipolysis is an important process determining fuel metabolism, and insulin regulates this process in adipose tissue...
  66. pmc Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    N Engl J Med 350:664-71. 2004
    ..Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown...
  67. ncbi Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
    J Biol Chem 284:2811-22. 2009
    ..Lactate activates GPR81 in its physiological concentration range of 1-20 mM and suppresses lipolysis in mouse, rat, and human adipocytes as well as in differentiated 3T3-L1 cells...
  68. ncbi Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice
    Véronique Rolli
    Immunogénétique Moléculaire Humaine, Centre de Recherche d Immunologie et d Hématologie, Faculte de Medecine, Hopitaux Universitaires de Strasbourg, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
    FEBS Lett 581:394-400. 2007
    ..This phenotype appeared to correlate with a significant decrease in adipocytic lipolysis that could not be rescued by several pharmacological agents including beta(3)-adrenoreceptor agonists...
  69. ncbi A comparative study of human GS2, its paralogues, and its rat orthologue
    Jay G Gao
    Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8702, USA
    Biochem Biophys Res Commun 360:501-6. 2007
    ..Since retinoid and triglyceride metabolites are transcription factor ligands, we expect that these enzymes will coordinately regulate epidermal homeostasis...
  70. ncbi Stimulation of lipolysis enhances the rate of cholesterol efflux to HDL in adipocytes
    Philip B Verghese
    Department of Biochemistry and Molecular Biology, Oklahoma State University, 147 Noble Research Center, Stillwater, OK 74078, USA
    Mol Cell Biochem 302:241-8. 2007
    ..beta-adrenergic activation of the lipolysis promotes a 22% increase in the extent of cholesterol efflux to reconstituted discoidal HDL particles...
  71. ncbi Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark)
    Takahiro Tsujita
    Bioscience, Integrated Center for Sciences, Ehime University, Ehime, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:547-51. 2007
    The lipolysis induced by Satsuma mandarin orange (Citrus unshu Mark) was investigated using rat fat cells...
  72. ncbi Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes Care 30:2916-21. 2007
    Insulin resistance, associated with increased lipolysis, results in a high exposure of nonadipose tissue to lipids...
  73. ncbi In vivo effects of leptin on autonomic nerve activity and lipolysis in rats
    Jiao Shen
    Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 416:193-7. 2007
    ..In this study, we investigated the in vivo effects of leptin on the autonomic nerve activity and lipolysis. We found that intravenous administration of leptin (10 microg/rat) excited the sympathetic nerves innervating ..
  74. ncbi Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 281:15837-44. 2006
    Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes...
  75. ncbi Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 282:996-1002. 2007
    ..A) mediates the actions of cyclic AMP-dependent protein kinase A (PKA) to stimulate triglyceride hydrolysis (lipolysis) in adipocytes...
  76. ncbi Increased rates of lipolysis among human immunodeficiency virus-infected men receiving highly active antiretroviral therapy
    Colleen Hadigan
    Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Metabolism 51:1143-7. 2002
    ..We hypothesized that HIV-infected subjects with fat redistribution have increased rates of lipolysis and increased circulating free fatty acid (FFA) levels that contribute to insulin resistance...
  77. ncbi Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    Y Huang
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:17483-90. 1998
    ..hE2(+/0), mE-/-), apoE2 levels also correlated positively with plasma triglyceride levels, suggesting impaired lipolysis in both hE2(+/0),LDLR-/- and hE2(+/0),mE-/- mice...
  78. ncbi Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels
    N R Coe
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St Paul, MN 55108, USA
    J Lipid Res 40:967-72. 1999
    ..To the contrary, basal lipolysis decreased approximately 40% in ALBP/aP2 nulls as compared to wild-type littermates...
  79. pmc Functional interaction of hormone-sensitive lipase and perilipin in lipolysis
    Wen Jun Shen
    Division of Endocrinology, Stanford University, Stanford, California 94305, USA
    J Lipid Res 50:2306-13. 2009
    Adipocyte lipolysis is controlled by complex interactions of lipases, cofactors, and structural proteins associated with lipid droplets...
  80. ncbi Fate of fat: the role of adipose triglyceride lipase in lipolysis
    Robert Zimmermann
    Insitute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Biochim Biophys Acta 1791:494-500. 2009
    b>Lipolysis, the coordinated catabolism of triacylglycerol (TG) stored in cellular lipid droplets, provides fatty acids, di-, and monoglycerides...
  81. ncbi Decreased lipolysis and enhanced glycerol and glucose utilization by adipose tissue prior to development of obesity in monosodium glutamate (MSG) treated-rats
    M Dolnikoff
    Department of Physiology, , Brazil
    Int J Obes Relat Metab Disord 25:426-33. 2001
    ..In addition, the enhanced lipogenesis and glycerol reutilization seen in their adipose tissue, disturbs the normal balance between fat depots breakdown and accumulation in favor of the latter...
  82. ncbi Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice
    W Zhai
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    Horm Metab Res 42:247-53. 2010
    ..Plasma FFA concentrations are primarily governed by lipolysis in adipocytes. Perilipin surrounds the lipid droplet in adipocytes and has a dual role in lipolysis regulation...
  83. ncbi Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
    Achim Lass
    Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A 8010 Graz, Austria
    Cell Metab 3:309-19. 2006
    ..Finally, expression of functional CGI-58 in CDS fibroblasts restores lipolysis and reverses the abnormal TG accumulation typical for CDS...
  84. ncbi Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    Takeshi Inagaki
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 5:415-25. 2007
    ..FGF21 in turn stimulates lipolysis in white adipose tissue and ketogenesis in liver...
  85. pmc Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion
    Marie Line Peyot
    Molecular Nutrition Unit and Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec H1W4A4, Canada
    J Biol Chem 284:16848-59. 2009
    Reduced lipolysis in hormone-sensitive lipase-deficient mice is associated with impaired glucose-stimulated insulin secretion (GSIS), suggesting that endogenous beta-cell lipid stores provide signaling molecules for insulin release...
  86. ncbi The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis
    M Ryden
    Department of Medicine, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden
    Int J Obes Relat Metab Disord 25:1599-603. 2001
    ..The beta1-adrenoceptor is a candidate gene for obesity because of its role in catecholamine-induced energy homeostasis. A common Arg 389 Gly variant polymorphism has been shown in recombinant cells to influence its-coupling properties...
  87. ncbi Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice
    Pradip K Saha
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 279:35150-8. 2004
    Targeted disruption of the lipid droplet protein, perilipin, in mice leads to constitutional lipolysis associated with marked reduction in white adipose tissue as a result of unbridled lipolysis...
  88. ncbi Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake
    Bas Teusink
    TNO Prevention and Health, Gaubius Laboratory, NL 2301 CE Leiden, The Netherlands
    Diabetes 52:614-20. 2003
    ..The contribution of TG lipolysis to total plasma FA turnover was 10-20%...
  89. ncbi Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 94:219-30. 2008
    ..g. skeletal muscle) characterizes the obese insulin resistant state. Disturbances in pathways of lipolysis may play a role in the development and maintenance of these increased fat stores...
  90. ncbi Lipolysis--not inflammation, cell death, or lipogenesis--is involved in adipose tissue loss in cancer cachexia
    Mikael Ryden
    Department of Medicine, Karolinska Institute at Karolinska University Hospital, Stockholm, Sweden
    Cancer 113:1695-704. 2008
    ..A key feature of cancer cachexia is loss of white adipose tissue (WAT) because of increased adipocyte lipolysis and possibly reduced lipid synthesis (lipogenesis)...
  91. pmc Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    Adilson Guilherme
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 9:367-77. 2008
    ....
  92. ncbi Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans
    C B Djurhuus
    Department of Endocrinology and Diabetes, University Hospital of Aarhus, Aarhus Kommunehospital, Denmark
    Am J Physiol Endocrinol Metab 283:E172-7. 2002
    Cortisol's effects on lipid metabolism are controversial and may involve stimulation of both lipolysis and lipogenesis...
  93. ncbi Identification of potent agonists acting at an endogenous atypical beta3-adrenoceptor state that modulate lipolysis in rodent fat cells
    Bradford S Hamilton
    Department of Metabolic Diseases, Boehringer Ingelheim Pharma GmbH and Co KG, 88397 Biberach an der Riss, Germany
    Eur J Pharmacol 580:55-62. 2008
    ....
  94. ncbi The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism
    B Xue
    Departments of Nutrition and Medicine, The University of Tennessee, Knoxville, Tennessee 37996
    FASEB J 12:1391-6. 1998
    ..However, since recent data demonstrate that increasing adipocyte [Ca2+]i may also inhibit lipolysis, we have investigated the role of agouti-induced [Ca2+]i increases in regulating lipolysis in human adipocytes...
  95. ncbi A dynamic in vitro lipolysis model. II: Evaluation of the model
    N H Zangenberg
    Department of Pharmaceutics, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
    Eur J Pharm Sci 14:237-44. 2001
    A lipolysis model was characterised and evaluated by investigating the composition of the aqueous phase and the concentration of probucol and danazol in the aqueous phase...
  96. pmc The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis
    Angela Hommel
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Mol Cell Biol 30:1231-42. 2010
    ..Accordingly, basal lipolysis was increased after knockdown of Arfrp1 in 3T3-L1 adipocytes...
  97. pmc The skinny on fat: lipolysis and fatty acid utilization in adipocytes
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 9472, USA
    Trends Endocrinol Metab 20:424-8. 2009
    b>Lipolysis for the provision of fatty acids (FA) for other organs during times of energy demand occurs uniquely in white adipose tissue (WAT)...
  98. ncbi Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis
    Hiroaki Okazaki
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Diabetes 55:2091-7. 2006
    Molecular mechanisms underlying lipolysis, as defined by mobilization of fatty acids from adipose tissue, are not fully understood...
  99. ncbi Watching intracellular lipolysis in mycobacteria using time lapse fluorescence microscopy
    Rabeb Dhouib
    CNRS, Aix Marseille Université Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse UPR 9025, 31 Chemin Joseph Aiguier, 13402, Marseille, France
    Biochim Biophys Acta 1811:234-41. 2011
    ..The method presented here provides a powerful tool for monitoring in vivo lipolysis in mycobacteria and for obtaining new insights on the growth of cells and their entry into the dormant or ..
  100. pmc Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
    Kashan Ahmed
    Institute of Pharmacology, University of Heidelberg, and Department of General Pediatrics, University Children s Hospital Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 284:21928-33. 2009
    ..ligand receptor pair 3-OH-octanoic acid/GPR109B mediates in humans a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-..
  101. ncbi Time course of changes in in vitro lipolysis of intra-abdominal fat depots in relation to high-fat diet-induced hepatic steatosis in rats
    Pascal Collin
    Département de Kinésiologie, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Br J Nutr 96:268-75. 2006
    The purpose of the present study was to determine the time course of changes in in vitro lipolysis and in perilipin content (Western blot) in the mesenteric and/or the retroperitoneal fat depots in relation to the development of hepatic ..

Research Grants11

  1. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    Growth hormone (GH) promotes protein synthesis and lipolysis. In turn, metabolic disturbances are associated with alteration in GH production which contribute to the pathophysiology of clinically relevant disorders such as malnutrition, ..
  2. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ..manifest the metabolic effects of persistent GR activation fat, muscle, and liver, namely, increased whole body lipolysis, increased hepatic lipogenesis, enhanced triglyceride storage in abdominal fat, increased protein turnover, and ..
  3. PANCREATIC LIPASES AND COLIPASE IN LIPOLYSIS AND OBESITY
    Mark Lowe; Fiscal Year: 2007
    ..Taken together the completion of these studies will increase our understanding of fat digestion and the regulation of fat intake. ..
  4. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..adipose triglyceride lipase gene or the adipokinetic hormone receptor gene (which acts like glucagon to drive lipolysis). This observation provides a framework for identifying new genes that control lipid metabolism...
  5. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..GPCR) expressed predominantly in adipose tissue, where it mediates the effects of noradrenaline-stimulated lipolysis in white adipose tissue (WAT) and thermogenesis in brown adipose tissue (BAT)...
  6. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
    ..vascular wall" HL55667, years 8-11, has provided new observations that frame the renewal of this project: TGRL lipolysis products in moderate to high concentrations cause release of transforming growth factor (TGF)-21 from ..
  7. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..receptors ([unreadable]ARs) are key regulators of adipose tissue metabolism to control (i) lipolysis for mobilization of stored energy and (ii) adaptive thermogenesis in brown fat...
  8. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..synthesis (such as fatty acid synthase (FAS)), and/or increased uptake of circulating lipids derived from diet (lipolysis)...
  9. TONIC ACTIVITY OF ADENOSINE A1-ADENOSINE RECEPTORS
    John Shryock; Fiscal Year: 2003
    For many years it has been recognized that adenosine is a potent and efficacious inhibitor of lipolysis and adenylate and adenylate cyclase activity in white adipose tissue...
  10. BETA 3-ADRENOCEPTORS AND MAP KINASE IN ADIPOCYTES
    Sheila Collins; Fiscal Year: 2003
    ..GPCR) expressed predominantly in adipose tissue, where it mediates the effects of noradrenaline-stimulated lipolysis in white adipose tissue (WAT) and thermogenesis in brown adipose tissue (BAT)...
  11. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..with protease inhibitor therapy is caused by 1) reduced conversion of VLDL to LDL due to reduced triglyceride lipolysis caused early in susceptible patients by protease inhibitors themselves; 2) increased VLDL apoB production ..