respiratory transport

Summary

Summary: The processes of diffusion across the BLOOD-AIR BARRIER, and the chemical reactions coupled with diffusion that effect the rate of PULMONARY GAS EXCHANGE, generally at the alveolar level.

Top Publications

  1. pmc Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system
    Brian E Carlson
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Adv Exp Med Biol 614:353-60. 2008
  2. ncbi An axisymmetric single-path model for gas transport in the conducting airways
    Srinath Madasu
    Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    J Biomech Eng 128:69-75. 2006
  3. ncbi Effects of thoracic epidural anesthesia on hemodynamics and global oxygen transport in ovine endotoxemia
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Shock 26:615-9. 2006
  4. ncbi Pulsatile blood flow and gas exchange across a cylindrical fiber array
    Kit Yan Chan
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biomech Eng 129:676-87. 2007
  5. ncbi Effects of Quillaja saponins on growth, metabolism, egg production and muscle cholesterol in individually reared Nile tilapia (Oreochromis niloticus)
    G Francis
    Department of Animal Nutrition and Aquaculture, Institute for Animal Production in the Tropics and Subtropics, University of Hohenheim (480, D 70593, Stuttgart, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 129:105-14. 2001
  6. ncbi Adverse effects of dopamine on systemic hemodynamic status and oxygen transport in neonates after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 48:1859-64. 2006
  7. ncbi Liver-intestine transplant from a pediatric donor with unrecognized mitochondrial succinate cytochrome C reductase deficiency
    Aaron R Zucker
    Division of Pediatric Critical Care, Connecticut Children s Medical Center, Hartford, CT, USA
    Transplantation 79:356-8. 2005
  8. ncbi [Respiratory responses to microinjections of leptin into the solitary tract nucleus]
    A N Iniushkin
    Ross Fiziol Zh Im I M Sechenova 94:95-108. 2008
  9. ncbi Pulsatile blood flow and oxygen transport past a circular cylinder
    Jennifer R Zierenberg
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2099, USA
    J Biomech Eng 129:202-15. 2007
  10. pmc Effect of carrier gas properties on aerosol distribution in a CT-based human airway numerical model
    Shinjiro Miyawaki
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Ann Biomed Eng 40:1495-507. 2012

Scientific Experts

Detail Information

Publications88

  1. pmc Modeling oxygen and carbon dioxide transport and exchange using a closed loop circulatory system
    Brian E Carlson
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Adv Exp Med Biol 614:353-60. 2008
    ..The blood-tissue gas exchange model has been incorporated into a higher level model of the circulatory system plus pulmonary mechanics and gas exchange using the RBC and plasma equations to account for pH and CO2 buffering in the blood...
  2. ncbi An axisymmetric single-path model for gas transport in the conducting airways
    Srinath Madasu
    Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA
    J Biomech Eng 128:69-75. 2006
    ....
  3. ncbi Effects of thoracic epidural anesthesia on hemodynamics and global oxygen transport in ovine endotoxemia
    Fritz Daudel
    Department of Intensive Care Medicine, University Hospital Bern, Freiburgstrasse, 3010 Bern, Switzerland
    Shock 26:615-9. 2006
    ..Urinary output was increased in the TEA group as compared with the control group (P < 0.05). In this model of endotoxic shock, TEA improved renal perfusion without affecting cardiopulmonary hemodynamics and global oxygen transport...
  4. ncbi Pulsatile blood flow and gas exchange across a cylindrical fiber array
    Kit Yan Chan
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biomech Eng 129:676-87. 2007
    ..Maximum local shear stress is provided as a possible indicator of thrombosis, and the computed shear stress is shown to be below the threshold value for thrombosis formation for all cases evaluated...
  5. ncbi Effects of Quillaja saponins on growth, metabolism, egg production and muscle cholesterol in individually reared Nile tilapia (Oreochromis niloticus)
    G Francis
    Department of Animal Nutrition and Aquaculture, Institute for Animal Production in the Tropics and Subtropics, University of Hohenheim (480, D 70593, Stuttgart, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 129:105-14. 2001
    ..The muscle cholesterol level in the S300 group was significantly higher than that of the C group. Possible mechanisms of action of the dietary saponins are discussed...
  6. ncbi Adverse effects of dopamine on systemic hemodynamic status and oxygen transport in neonates after the Norwood procedure
    Jia Li
    Cardiac Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Am Coll Cardiol 48:1859-64. 2006
    ..The purpose of this study was to evaluate the effects of dopamine on hemodynamic status and oxygen transport in neonates after the Norwood procedure...
  7. ncbi Liver-intestine transplant from a pediatric donor with unrecognized mitochondrial succinate cytochrome C reductase deficiency
    Aaron R Zucker
    Division of Pediatric Critical Care, Connecticut Children s Medical Center, Hartford, CT, USA
    Transplantation 79:356-8. 2005
    ..the first case in which liver and small bowel were procured from a donor with an unsuspected mitochondrial respiratory transport chain defect (succinate cytochrome C reductase deficiency)...
  8. ncbi [Respiratory responses to microinjections of leptin into the solitary tract nucleus]
    A N Iniushkin
    Ross Fiziol Zh Im I M Sechenova 94:95-108. 2008
    ....
  9. ncbi Pulsatile blood flow and oxygen transport past a circular cylinder
    Jennifer R Zierenberg
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2099, USA
    J Biomech Eng 129:202-15. 2007
    ..The effect of pulsatility on Sh is greater at larger Re. Increasing Re aids transport, but yields a higher cylinder drag force and shear stresses on the cylinder surface which are potentially undesirable...
  10. pmc Effect of carrier gas properties on aerosol distribution in a CT-based human airway numerical model
    Shinjiro Miyawaki
    Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Ann Biomed Eng 40:1495-507. 2012
    ....
  11. doi Effect of ticagrelor on pulmonary function in healthy elderly volunteers and asthma or chronic obstructive pulmonary disease patients
    Kathleen Butler
    AstraZeneca LP, Wilmington, DE 19850 5437, USA
    Curr Med Res Opin 29:569-77. 2013
    ..Dyspnea is one of the most commonly reported adverse events associated with ticagrelor...
  12. doi An in vitro study on the deposition of micrometer-sized particles in the extrathoracic airways of adults during tidal oral breathing
    L Golshahi
    Department of Mechanical Engineering, University of Alberta, Edmonton, AB, T6G2G8, Canada
    Ann Biomed Eng 41:979-89. 2013
    ..51 x 10(5)(Stk(3.03)Re(0.25)) + 1)] x 100. Moreover, the "Alberta Idealized Adult Throat" is found to mimic average deposition, given in past in vivo studies, in the upper airways of adults during natural tidal breathing...
  13. doi Effects of Fastac 50 EC on bumble bee Bombus terrestris L. respiration: DGE disappearance does not lead to increasing water loss
    Riin Muljar
    Department of Plant Protection, Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Kreutzwaldi 1, Tartu 51014, Estonia
    J Insect Physiol 58:1469-76. 2012
    ..Treatment with 0.002% Fastac 50 EC solution had no significant effect on respiration patterns or longevity. We found no evidence for the DGE cycles functioning as a water saving mechanism...
  14. ncbi Impacts of ocean acidification on respiratory gas exchange and acid-base balance in a marine teleost, Opsanus beta
    Andrew J Esbaugh
    Division of Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149, USA
    J Comp Physiol B 182:921-34. 2012
    ....
  15. doi Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes: an important cause of stroke in young people
    John Aaron Goodfellow
    Institute of Neurological Sciences, Department of Neurology, Southern General Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
    Postgrad Med J 88:326-34. 2012
    ..Eighty per cent of cases have the mitochondrial mutation m.3243A>G which is linked to respiratory transport chain dysfunction and oxidative stress in energy demanding organs, particularly muscle and brain...
  16. doi Hypoxia tolerance in elasmobranchs. I. Critical oxygen tension as a measure of blood oxygen transport during hypoxia exposure
    Ben Speers-Roesch
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4
    J Exp Biol 215:93-102. 2012
    ....
  17. doi Pressure oscillation delivery to the lung: Computer simulation of neonatal breathing parameters
    Ahmed M Al-Jumaily
    Institute of Biomedical Technologies, Auckland University of Technology, Auckland, New Zealand
    J Biomech 44:2649-58. 2011
    ..The respiratory parameters at the airway opening compare well with those measured from experiments. The model demonstrates the ability to predict pressures, flows and volumes in the alveolar regions of a premature ovine lung...
  18. doi In vitro kinetics of oxygen transport in erythrocyte suspension or unmodified hemoglobin solution from human and other animals
    Weiyan Peng
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, P R China
    Can J Physiol Pharmacol 89:631-7. 2011
    ....
  19. ncbi [Oxygen-transport function of the blood and endothelial dysfunction in patients with angina pectoris and arterial hypertension]
    A V Iankovskaia
    Kardiologiia 47:22-7. 2007
    ..This affects formation of various NO-derivatives of hemoglobin and oxygen transport system of the blood...
  20. pmc Gas and aerosol mixing in the acinus
    Akira Tsuda
    Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Respir Physiol Neurobiol 163:139-49. 2008
    ..We end with a few comments on some issues unique to the neonatal and developing lung...
  21. ncbi Cyclic gas exchange in the giant burrowing cockroach, Macropanesthia rhinoceros: effect of oxygen tension and temperature
    James D Woodman
    CSIRO Entomology, GPO Box 1700, Canberra ACT 2601, Australia
    J Insect Physiol 53:497-504. 2007
    ..During CGE, an increase in temperature from 10 to 20 degrees C caused both water loss and CO(2) output to double; from 20 to 30 degrees C, CO(2) output again doubled but water loss increased by only 31%...
  22. ncbi Electrophoretic, size-exclusion high-performance liquid chromatography and liquid chromatography-electrospray ionization ion trap mass spectrometric detection of hemoglobin-based oxygen carriers
    Phaedra Dora Simitsek
    Athens Doping Control Laboratory, Olympic Athletic Center of Athens Spiros Louis, 37 Kifissias Avenue, 151 23 Maroussi, Athens, Greece
    Anal Chim Acta 583:223-30. 2007
    ....
  23. ncbi [Effect of nebivolol on the blood oxygen transport]
    V V Zinchuk
    Eksp Klin Farmakol 70:44-7. 2007
    ..In this case, NO acts as an important modifier of the hemoglobin function...
  24. pmc The Campylobacter jejuni NADH:ubiquinone oxidoreductase (complex I) utilizes flavodoxin rather than NADH
    Dilan R Weerakoon
    Department of Microbiology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Bacteriol 190:915-25. 2008
    ..jejuni. A model is presented in which CJ1574 mediates electron flow into the respiratory transport chain from reduced flavodoxin and through complex I.
  25. pmc The structural design of the bat wing web and its possible role in gas exchange
    Andrew N Makanya
    Department of Veterinary Anatomy and Physiology, University of Nairobi, Kenya
    J Anat 211:687-97. 2007
    ..019 ml O2 min(-1) mmHg(-1). We conclude that in Epomophorus wahlbergi, the wing web has structural modifications that permit a substantial contribution to the total gas exchange...
  26. ncbi Effect of aerial O2 partial pressure on bimodal gas exchange and air-breathing behaviour in Trichogaster leeri
    Lesley A Alton
    Environmental Biology, School of Earth and Environmental Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia
    J Exp Biol 210:2311-9. 2007
    ....
  27. ncbi Effects of warm-up intensity on oxygen transport during supramaximal exercise in horses
    Kazutaka Mukai
    Equine Research Institute, Japan Racing Association, 321 4 Tokami cho, Utsunomiya City, Tochigi Prefecture 320 0856, Japan
    Am J Vet Res 69:690-6. 2008
    ..To determine whether warm-up exercise at different intensities alters kinetics and total contribution of aerobic power to total metabolic power in subsequent supramaximal exercise in horses...
  28. pmc Physiological determinants of the pulmonary filtration coefficient
    James C Parker
    Department of Physiology and Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Lung Cell Mol Physiol 295:L235-7. 2008
    ..A consistent K(f) is dependent on accurately separating the filtration and vascular volume components of lung weight gain, then K(f) is a consistent and repeatable index of lung vascular permeability...
  29. ncbi Beyond anemia: the clinical impact of the physiologic effects of erythropoietin
    Charles J Diskin
    Department of Hypertension, Nephrology, Dialysis and Transplantation, Auburn University, Opelika, Alabama 36801, USA
    Semin Dial 21:447-54. 2008
    ..We will review what is known about the physiology of this plasma factor that, it is now clear, is more than just an erythrocyte production factor...
  30. pmc Why chaotic mixing of particles is inevitable in the deep lung
    Akira Tsuda
    Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Theor Biol 286:57-66. 2011
    ..We also explain why self-similarity occurs in the alveolar system and was indeed observed as a fractal pattern deep in rat lungs (Proc. Natl. Acad. Sci. USA. 99:10173-10178, 2002)...
  31. doi BOLD contrast and noise characteristics of densely sampled multi-echo fMRI data
    Mark Chiew
    Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9 ON, Canada
    IEEE Trans Med Imaging 30:1691-703. 2011
    ..Simulations and experiments also emphasized that noise correlations between echoes are likely the main factor limiting the potential CNR gains achievable by densely sampled multi-echo fMRI...
  32. doi The effect of ambient humidity and metabolic rate on the gas-exchange pattern of the semi-aquatic insect Aquarius remigis
    Heidy L Contreras
    Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine, CA 92697 2525, USA
    J Exp Biol 214:1086-91. 2011
    ..The results are discussed in the context of the ongoing discussion in the literature of the origin, maintenance and adaptive significance of the DGC in insects...
  33. doi Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial
    Yuk Ling Dai
    Cardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong
    Atherosclerosis 216:395-401. 2011
    ..whether co-enzyme Q10 (CoQ) supplementation, which is an obligatory coenzyme in the mitochondrial respiratory transport chain, can reverse MD and improve endothelial function in patients with ischaemic left ventricular ..
  34. doi Derivation of mass transfer coefficients for transient uptake and tissue disposition of soluble and reactive vapors in lung airways
    B Asgharian
    Applied Research Associates, Inc, Raleigh, NC, USA
    Ann Biomed Eng 39:1788-804. 2011
    ..While model predictions were performed for formaldehyde, which serves as a model of physiologically relevant, highly reactive vapors, the model is equally applicable to other soluble and reactive compounds...
  35. ncbi Ionic support of the cough reflex
    Bolesław Banach
    Zakład Fizjologii Pomorskiej Akademii Medycznej w Szczecinie al Powstańców Wlkp 72, 70 111 Szczecin
    Ann Acad Med Stetin 55:40-50. 2009
    ..The conditions were identified for examination of chloride secretion in the airways presented as the chemical isolation of chloride currents with the use of amiloride...
  36. doi Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HIV patients
    Lloyd Einsiedel
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Mitochondrion 10:534-9. 2010
    ..stavudine-based highly active antiretroviral therapy (HAART) is associated with impaired mitochondrial respiratory transport chain function in patient derived CD4+PBLs...
  37. doi Pretreatment with hemoglobin-based oxygen carriers protect isolated rat heart from myocardial infarction
    Tao Li
    Laboratory of Anesthesiology and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
    Artif Cells Blood Substit Immobil Biotechnol 38:115-8. 2010
    ..Moreover, the myocardial infarction and troponin-I release were significantly reduced in the pre-HBOCs group. Therefore, PolyPHb pretreatment was protective to the isolated I/R heart...
  38. pmc Intra-individual variation allows an explicit test of the hygric hypothesis for discontinuous gas exchange in insects
    Caroline M Williams
    Department of Biology, University of Western Ontario, London, ON N6A 5B7, Canada
    Biol Lett 6:274-7. 2010
    ..Thus, DGCs reduce RWL in E. propertius, which is consistent with the suggestion that water loss reduction could account for the evolutionary origin and/or maintenance of DGCs in insects...
  39. doi Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial
    Dinna N Cruz
    Department of Nephrology, Dialysis, and Transplantation, St Bortolo Hospital and International Renal Research Institute Vicenza, 36100 Vicenza, Italy
    JAMA 301:2445-52. 2009
    ..Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin. Reducing circulating endotoxin levels with polymyxin B hemoperfusion could potentially improve patient clinical outcomes...
  40. doi Membrane-associated carbonic anhydrase in the respiratory system of the Pacific hagfish (Eptatretus stouti)
    Andrew J Esbaugh
    Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Respir Physiol Neurobiol 166:107-16. 2009
    ..These results demonstrate that Pacific hagfish possess gill and RBC plasma-accessible membrane-associated CA that may play important roles in respiratory gas exchange and acid-base balance...
  41. ncbi Respiratory responses to microinjections of leptin into the solitary tract nucleus
    A N Inyushkin
    Samara State University, 1 Academician Pavlov Street, 443016, Samara, Russia
    Neurosci Behav Physiol 39:231-40. 2009
    ....
  42. doi Metabolic rate controls respiratory pattern in insects
    H L Contreras
    University of California Irvine, Ecology and Evolutionary Biology, Irvine, CA 92697, USA
    J Exp Biol 212:424-8. 2009
    ..Examples of each type of pattern are shown using the insect Rhodnius prolixus. In addition, contrary to the expectations deriving from the hygric hypothesis, it is demonstrated that the DGC does not cease in Rhodnius in humid air...
  43. ncbi Modeling airflow and particle transport/deposition in pulmonary airways
    Clement Kleinstreuer
    Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 7910, USA
    Respir Physiol Neurobiol 163:128-38. 2008
    ..Concerning inhaled therapeutic particles, optimal parameters for mechanical drug-aerosol targeting of predetermined lung areas can be computed, given representative pulmonary airways...
  44. doi Both allergic and nonallergic asthma are associated with increased FE(NO) levels, but only in never-smokers
    A Malinovschi
    Department of Medical Cell Biology Integrative Physiology, Uppsala University, Uppsala, Sweden
    Allergy 64:55-61. 2009
    ..The aim of this study is to analyze the effect of having allergic or nonallergic asthma on exhaled nitric oxide levels, with special regard to smoking history...
  45. ncbi Body size-independent safety margins for gas exchange across grasshopper species
    Kendra J Greenlee
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Biol 210:1288-96. 2007
    ..These comparative data strengthen the growing body of evidence that body size does not affect the safety margin for oxygen delivery in insects...
  46. ncbi Cardiac malformation in neonatal mice lacking connexin43
    A G Reaume
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 267:1831-4. 1995
    ..This finding suggests that Cx43 plays an essential role in heart development but that there is functional compensation among connexins in other parts of the developing fetus...
  47. ncbi Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs
    Natalya Nowak
    Chemical Engineering Department, Applied Biomedical Engineering Program, Cleveland State University and The Cleveland Clinic Foundation, 1960 E 24th Street, Stilwell Hall 462, Cleveland, OH 44115, USA
    Ann Biomed Eng 31:374-90. 2003
    ..The results of this study suggest that under most conditions, an idealized model based on the Weibel dimensions is not sufficient to predict deposition, and an accurate model, such as those based on imaging techniques may be required...
  48. ncbi Effects of titrated arginine vasopressin on hemodynamic variables and oxygen transport in healthy and endotoxemic sheep
    Martin Westphal
    Department of Anaesthesiology and Intensive Care, University of Muenster, Germany
    Crit Care Med 31:1502-8. 2003
    ..To determine the effects of titrated arginine vasopressin (AVP) alone or in combination with norepinephrine (NE) on hemodynamics and oxygen transport in healthy and endotoxemic sheep...
  49. ncbi Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia
    Joseph P Mizgerd
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Respir Crit Care Med 168:810-7. 2003
    ..We interpret these studies to indicate that endogenous p50 protects the host by curbing inflammatory responses to prevent injury, essential to survive pneumonia...
  50. ncbi Dysregulation of endogenous carbon monoxide and nitric oxide production in patients with advanced ischemic or nonischemic cardiomyopathy
    Niranjan Seshadri
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 92:820-3. 2003
    ..The differential responses in exhaled CO and NO at rest or with exercise between patients with cardiomyopathy and normal controls may point to dysregulation in endogenous CO and NO production...
  51. ncbi Oxygen transport dynamics after resuscitation with a conjugated hemoglobin solution
    Shaheen Wirk
    Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Surg 139:55-60. 2004
    ....
  52. ncbi Seasonal changes in blood oxygen transport and acid-base status in the tegu lizard, Tupinambis merianae
    Denis V Andrade
    Departamento de Zoologia, Universidade Estadual Paulista, Caixa Postal 199, 13500 970 Rio Claro, SP, Brazil
    Respir Physiol Neurobiol 140:197-208. 2004
    ..Arterial pH (pHa) of dormant animals is reduced compared to active lizards at body temperatures below 15 degrees C, while no significant difference was noticed at higher temperatures...
  53. ncbi Blood oxygen transport and endothelial dysfunction in patients with arterial hypertension
    V V Zinchuk
    Department of Physiology, Grodno State Medical University, Gorky str 80, 230015 Grodno, Belarus
    Clin Physiol Funct Imaging 24:205-11. 2004
    ..These data support the notion that endothelial dysfunction may alter haemoglobin-oxygen affinity and tissue oxygen supply in vivo. Alternation of haemoglobin-oxygen supply may be involved in the pathogenesis of hypertension...
  54. ncbi The hyperoxic switch: assessing respiratory water loss rates in tracheate arthropods with continuous gas exchange
    John R B Lighton
    University of Nevada at Las Vegas, Department of Biology, University of Nevada at Las Vegas, 4505 Maryland Parkway, NV 89154 4004, USA
    J Exp Biol 207:4463-71. 2004
    ..In P. californicus, which we were able to measure with and without a DGC, presence or absence of a DGC did not affect respiratory vs total water loss rates...
  55. ncbi Targeted delivery of antiprotease to the epithelial surface of human tracheal xenografts
    Thomas Ferkol
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Respir Crit Care Med 167:1374-9. 2003
    ....
  56. ncbi Terlipressin dose response in healthy and endotoxemic sheep: impact on cardiopulmonary performance and global oxygen transport
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University of Munster, Albert Schweitzer Strasse 33, 48149 Munster, Germany
    Intensive Care Med 29:301-8. 2003
    ....
  57. ncbi Oxygen transport with oscillations of inspired oxygen concentration
    E M Williams
    Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, UK
    Respir Physiol 108:79-87. 1997
    ..Our data illustrates that the link between the arterial and mixed-venous oscillations is non-linear and dependent on the sigmoidal binding relationship between oxygen and haemoglobin...
  58. ncbi The alcohol breath test--a review
    M P Hlastala
    Department of Physiology and Biophysics, University of Washington, Seattle 98195 6522, USA
    J Appl Physiol (1985) 84:401-8. 1998
    ..The dynamics of airway alcohol exchange results in a positively sloped exhaled alveolar plateau that contributes to considerable breathing pattern-dependent variation in measured breath alcohol concentration measurements...
  59. ncbi Ventilation heterogeneity is increased in hypocapnic dogs but not pigs
    K B Domino
    Department of Anesthesiology, University of Washington, Seattle 98195 6540, USA
    Respir Physiol 111:89-100. 1998
    ..05) in pigs. We conclude that hypocapnia increases ventilation heterogeneity in dogs but not in pigs, most likely related to an interspecies difference in collateral ventilation...
  60. ncbi Normal mechanisms of heat and moisture exchange in the respiratory tract
    D Irlbeck
    King Systems Corporation, Noblesville, Indiana, USA
    Respir Care Clin N Am 4:189-98. 1998
    ..The delivery of gases above or below normal physiologic levels has been shown to produce clinical problems...
  61. ncbi Optimization of the mammalian respiratory system: symmorphosis versus single species adaptation
    J H Jones
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    Comp Biochem Physiol B Biochem Mol Biol 120:125-38. 1998
    ..system at normoxic VO2max, the fraction of the total limitation to O2 flux contributed by each of the respiratory transport steps is calculated as either the fractional change (F) in VO2max for a 1% change in each component, or as ..
  62. ncbi The effect of changing the gaseous diffusion coefficient on the mass loss pattern of Hyalophora cecropia pupae
    G F Birchard
    Department of Biology, George Mason University, Fairfax, VA, 22030 4444, USA
    Physiol Biochem Zool 73:488-93. 2000
    ..This previously unreported gas phase resistance appears to be a major determinant of the duration of the open period and thus of overall water loss rates in these pupae...
  63. ncbi Characterization of the laryngeal jet using phase Doppler interferometry
    T E Corcoran
    Spray Systems Technology Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Aerosol Med 13:125-37. 2000
    ..This is likely due to the complex nature of the confined jet flow...
  64. ncbi Simulation of ozone uptake distribution in the human airways by orthogonal collocation on finite elements
    S C Hu
    Department of Chemical Engineering, Pennsylvania State University, University Park 16802
    Comput Biomed Res 25:264-78. 1992
    ..However, the tissue dose of ozone increased along the conducting airways, reached a maximal dose in the terminal bronchioles, and decreased sharply in the respiratory airways...
  65. ncbi The interplay of cutaneous water loss, gas exchange and blood flow in the toad, Bufo woodhousei: adaptations in a terrestrially adapted amphibian
    Warren W Burggren
    Department of Biological Sciences, University of North Texas, PO Box 305189, Denton, TX 76203, USA
    J Exp Biol 208:105-12. 2005
    ..Thus, Bufo woodhousei appears able to restrict cutaneous blood flow without compromising vital cutaneous CO2 loss...
  66. ncbi A new oxygen transport agent
    Thomas Standl
    Dept of Anesthesia and Critical Care Medicine Academic Hospital Solingen, Germany
    Haematologica 90:437-8. 2005
    ..Therefore, one cannot draw conclusions on the safety, tolerability and efficacy of MP4 in terms of red cell replacement when large amounts of oxygen carriers are needed...
  67. ncbi Splenectomy impairs diffusive oxygen transport in the lung of dogs
    D Merrill Dane
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9034, USA
    J Appl Physiol 101:289-97. 2006
    ..We conclude that splenic contraction enhances both convective and diffusive O2 transport and provides another compensatory mechanism for maintaining alveolar O2 transport in the presence of restrictive lung disease or ambient hypoxia...
  68. ncbi Three-dimensional computational fluid dynamics simulations of particle deposition in the tracheobronchial tree
    Kristin K Isaacs
    University of North Carolina at Chapel Hill, Department of Environmental Sciences and Engineering, Chapel Hill, North Carolina, USA
    J Aerosol Med 19:344-52. 2006
    ..CFD models may provide an efficient means of studying the complex effects of airway geometry, particle characteristics, and ventilatory parameters on particle deposition and therefore aid in the design of human subject experiments...
  69. ncbi Short-term effects of glipizide (an adenosine triphosphate-sensitive potassium channel inhibitor) on cardiopulmonary hemodynamics and global oxygen transport in healthy and endotoxemic sheep
    Matthias Lange
    Department of Anesthesiology and Intensive Care, University of Muenster, 48161 Muenster, Germany
    Shock 26:516-21. 2006
    ..Additional studies are required to determine the effects of continuous infusion of glipizide in the presence of systemic inflammation...
  70. ncbi A new drift-flux model for particle transport and deposition in human airways
    J B Wang
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
    J Biomech Eng 128:97-105. 2006
    ..Different deposition mechanisms can be combined into the mass conversation equation. Combined deposition efficiency for the three mechanisms simultaneously was evaluated and compared with two commonly used empirical expressions...
  71. ncbi Cyclic gas-exchange in the Chilean red cricket: inter-individual variation and thermal dependence
    Roberto F Nespolo
    Instituto de Ecologia y Evolucion, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
    J Exp Biol 210:668-75. 2007
    ..e. facilitation of gas exchange under hypoxic and hypercapnic conditions, minimizing evaporative water loss), although this assertion needs to be confirmed statistically by a strong inference approach...
  72. pmc Clarification of cyanide's effect on oxygen transport characteristics in a canine model
    Julius Cuong Pham
    Department of Anesthesia and Critical Care, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Meyer 297, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Emerg Med J 24:152-6. 2007
    ..To clarify the cardiovascular mechanisms of cyanide poisoning by evaluating oxygen transport characteristics using a canine model...
  73. ncbi Respiratory physiology: strange cycles and the fruit-fly's tongue
    John R B Lighton
    Department of Biological Sciences, University of Nevada at Las Vegas, NV 89154, USA
    Curr Biol 15:R965-6. 2005
    ..Drosophila in flight show an unexpected cyclicity in gas exchange even at constant metabolic flux rates--perhaps because regular proboscis extensions assist in providing oxygen to the fly's brain...
  74. ncbi [Experimental basis for using hypoxic training in the correction of oxygen transport system damage in aplastic anemia]
    I I Lanovenko
    Fiziol Zh 51:43-9. 2005
    ..Final results show positive effects of preventive application HT and HT during ET on the restoration of oxygen transport system in AA...
  75. ncbi To DGC or not to DGC: oxygen guarding in the termite Zootermopsis nevadensis (Isoptera: Termopsidae)
    John R B Lighton
    Department of Biology, University of Nevada at Las Vegas, NV 89154 4004, USA
    J Exp Biol 208:4671-8. 2005
    ..Termites may eschew the DGC because periodic flushing of the tracheal system with air may harm the obligate anaerobes upon which the lower termites depend for survival on their native diet of chewed wood...
  76. ncbi Unconventional mechanisms control cyclic respiratory gas release in flying Drosophila
    Fritz Olaf Lehmann
    Department of Neurobiology, University of Ulm, Germany
    J Exp Biol 208:3645-54. 2005
    ....
  77. ncbi Simulation of oxygen carrier mediated oxygen transport to C3A hepatoma cells housed within a hollow fiber bioreactor
    Jesse P Sullivan
    Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Illinois 46556, USA
    Biotechnol Bioeng 93:306-17. 2006
    ..Nonetheless, we demonstrate that the O2 transport model accurately predicts O2 consumption within a HF bioreactor, thus setting up the modeling framework for improving the design of future hepatic HF bioreactors...
  78. pmc Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways
    Ching Long Lin
    Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA
    Respir Physiol Neurobiol 157:295-309. 2007
    ..Thus, airflow modeling, particularly subject specific evaluations, should consider upper as well as intra-thoracic airway geometry...
  79. ncbi A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol
    Magnus Bjorkholm
    Karolinska Hospital and Institute, Stockholm, Sweden
    Haematologica 90:505-15. 2005
    ..A phase I clinical trial of MP4 was undertaken to evaluate whether MP4 elicits the clinical side effects associated with previous hemoglobin-based solutions...
  80. ncbi Pulsatile flow and mass transport over an array of cylinders: gas transfer in a cardiac-driven artificial lung
    Kit Yan Chan
    Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biomech Eng 128:85-96. 2006
    ..For most cases shown, an increase in gas transfer is accompanied by a higher pressure drop required to power the flow through the device...
  81. ncbi Correlated patterns of tracheal compression and convective gas exchange in a carabid beetle
    John J Socha
    Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA
    J Exp Biol 211:3409-20. 2008
    ..This study suggests that intra-tracheal and trans-spiracular convection of air driven by active tracheal compression may be a major component of ventilation for many insects...
  82. ncbi Respiratory assessment in adults
    T Moore
    School of Health and Social Sciences, Middlesex University, Middlesex
    Nurs Stand 21:48-56; quiz 58. 2007
    ..This article highlights the role of the nurse in respiratory assessment and discusses the implications of clinical findings...
  83. ncbi Control of the respiratory pattern in insects
    Timothy J Bradley
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA, USA
    Adv Exp Med Biol 618:211-20. 2007
    ..The minute to minute balance between these two processes, one delivering oxygen the other removing it, determines the pattern of respiration exhibited by the insect at any given time...
  84. ncbi Fluid dynamics modeling of particulate deposition in the lungs
    D Fontana
    Dipartimento di Scienze dei Materiali e Ingegneria Chimica, Politecnico di Torino, Turin, Italy
    Int J Artif Organs 28:667-77. 2005
    ..A method to create a realistic velocity profile at the inlet of the domain was developed, in order to obtain data about particle deposition also reliable about the first bifurcation, unlike previous works...
  85. ncbi Assessment of cardio-pulmonary efficiency in athletes and non-athletes
    P K Das Gupta
    Department of Physiology, Nilratan Sircar Medical College, Calcutta
    Indian J Physiol Pharmacol 35:245-8. 1991
    ....
  86. ncbi Targeted oxygen delivery within hepatic hollow fiber bioreactors via supplementation of hemoglobin-based oxygen carriers
    Jesse P Sullivan
    Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biotechnol Prog 22:1374-87. 2006
    ..Our results demonstrate that HBOCs can enhance O(2) delivery to cultured hepatocytes, while exposing them to in vivo-like O(2) tensions, which is critical to create a fully functional BLAD...
  87. ncbi The effects of inadequate humidity
    R D Branson
    Department of Surgery, University of Cincinnati, Ohio, USA
    Respir Care Clin N Am 4:199-214. 1998
    ..In neonates, the use of heated humidification during surgery may help contribute to thermal balance owing to the unique issues of temperature regulation and control in these patients...
  88. ncbi Breathe softly, beetle: continuous gas exchange, water loss and the role of the subelytral space in the tenebrionid beetle, Eleodes obscura
    Pablo E Schilman
    Division of Biological Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0116, USA
    J Insect Physiol 54:192-203. 2008
    ..This "conductance constraint hypothesis" may help to explain the otherwise puzzling phylogenetic patterns of continuous vs. discontinuous gas exchange observed in tracheate arthropods...

Research Grants35

  1. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2007
    ....
  2. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2000
    ....
  3. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2004
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  4. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2005
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. ..
  5. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2005
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  6. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2005
    ..abstract_text> ..
  7. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2006
    ..abstract_text> ..
  8. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2006
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. [unreadable] [unreadable]..
  9. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2006
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  10. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2007
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. [unreadable] [unreadable]..
  11. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2007
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  12. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2004
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. ..
  13. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2007
    ..abstract_text> ..
  14. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2003
    ..At the same time the findings of this project may lay down the foundation for realistic and rationally based inhalation dosimetry in children - a matter of great clinical importance. ..
  15. Particles in Developing Lung: Bioengineering Approach
    Akira Tsuda; Fiscal Year: 2003
    ..This knowledge has important implications for the estimation of health hazards posed by particulate air pollution and for the establishment of age-appropriate doses of therapeutic drugs delivered by aerosols. ..
  16. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2003
    ....
  17. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2001
    ....
  18. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2008
    ..abstract_text> ..
  19. CHAOTIC MIXING OF AEROSOL IN RHYTHMICALLY EXPANDING LUNG
    Akira Tsuda; Fiscal Year: 2002
    ....
  20. TRPV4 Initiates Ventilator Induced Lung Injury
    James Parker; Fiscal Year: 2009
    ..and that lung PAR1 and PAR2 activation peptidesincrease lung vascular permeability in TRPV4+/+ mice ventilated with high airway pressures but not in TRPV4-/- mice, or either genotype ventilated with low airway pressures ..
  21. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2009
    ....
  22. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  23. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2008
    ....
  24. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2008
    ..Such knowledge will be essential to guiding future studies aiming to manipulate innate immune signaling in order to prevent or treat lung infections. ..
  25. Regulation and function of STAT3 during pneumonia
    JOSEPH MIZGERD; Fiscal Year: 2008
    ..Elucidating the regulation and function of IL-6 and STAT3 during pneumonia will provide molecular targets for improving host defense and preventing lung injury in patients with or at risk for lung infections. ..
  26. Mechanical Injury to Lung Endothelium
    James Parker; Fiscal Year: 2001
    ....
  27. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2001
    ..abstract_text> ..
  28. AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR
    James Parker; Fiscal Year: 2002
    ..Other applications include continuous intrapulmonary administration of drugs and anesthetics and clearance of material from the lungs...
  29. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2002
    ..abstract_text> ..
  30. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2003
    ..abstract_text> ..
  31. Targeted Delivery of Interleukin-10
    Thomas Ferkol; Fiscal Year: 2004
    ..abstract_text> ..
  32. Genetic variants of primary ciliary dyskinesia
    Thomas Ferkol; Fiscal Year: 2006
    ..Using this approach, we will define the genetic spectrum of PCD, and correlate specific genetic variants with clinical presentations of this disease, especially during the neonatal period. ..
  33. Delivering antiproteases to the bronchiectatic airway
    Thomas Ferkol; Fiscal Year: 2006
    ....
  34. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
    ..and that lung PAR1 and PAR2 activation peptidesincrease lung vascular permeability in TRPV4+/+ mice ventilated with high airway pressures but not in TRPV4-/- mice, or either genotype ventilated with low airway pressures ..
  35. NF-kappaB and Innate Immunity in the Lungs
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..Such knowledge will be essential to guiding future studies aiming to manipulate innate immune signaling in order to prevent or treat lung infections. ..