protein transport

Summary

Summary: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Top Publications

  1. ncbi Trafficking of tail-anchored proteins: transport from the endoplasmic reticulum to the plasma membrane and sorting between surface domains in polarised epithelial cells
    Alessandra Bulbarelli
    Consiglio Nazionale delle Ricerche Cellular and Molecular Pharmacology Center and Department of Medical Pharmacology, University of Milan, Milan, Italy
    J Cell Sci 115:1689-702. 2002
  2. ncbi An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin
    Christina Wasmeier
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    Traffic 6:474-87. 2005
  3. ncbi One step at a time: endoplasmic reticulum-associated degradation
    Shruthi S Vembar
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Rev Mol Cell Biol 9:944-57. 2008
  4. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
  5. ncbi A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants
    Brook K Nelson
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 51:1126-36. 2007
  6. ncbi Importing mitochondrial proteins: machineries and mechanisms
    Agnieszka Chacinska
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    Cell 138:628-44. 2009
  7. ncbi A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 429:841-7. 2004
  8. ncbi Genome-scale identification of Legionella pneumophila effectors using a machine learning approach
    David Burstein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    PLoS Pathog 5:e1000508. 2009
  9. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
  10. ncbi Protein translocation across the bacterial cytoplasmic membrane
    Arnold J M Driessen
    Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and the Zernike Institute for Advanced Materials, University of Groningen, Haren, The Netherlands
    Annu Rev Biochem 77:643-67. 2008

Research Grants

  1. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2010
  2. STRUCTURE, BIOSYNTHESIS AND FUNCTION OF GLYCOPROTEINS
    Stuart Kornfeld; Fiscal Year: 2007
  3. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2010
  4. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
  5. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    KARLETT PARRA; Fiscal Year: 2009
  6. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
  7. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
  8. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
  9. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2011
  10. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2000

Detail Information

Publications262 found, 100 shown here

  1. ncbi Trafficking of tail-anchored proteins: transport from the endoplasmic reticulum to the plasma membrane and sorting between surface domains in polarised epithelial cells
    Alessandra Bulbarelli
    Consiglio Nazionale delle Ricerche Cellular and Molecular Pharmacology Center and Department of Medical Pharmacology, University of Milan, Milan, Italy
    J Cell Sci 115:1689-702. 2002
    ..The two GFP fusion proteins showed a different surface distribution, which is consistent with a role for the two syntaxin TMDs in polarised sorting...
  2. ncbi An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin
    Christina Wasmeier
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    Traffic 6:474-87. 2005
    ..The endocytosis and DCV targeting of phogrin Y(654) > A mutants correlated with the impaired binding of the phogrin cytosolic tail to the micro-subunit of the AP2 adaptor complex in vitro...
  3. ncbi One step at a time: endoplasmic reticulum-associated degradation
    Shruthi S Vembar
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Rev Mol Cell Biol 9:944-57. 2008
    ..Here, we summarize our current understanding of each step during ERAD, with emphasis on the factors that catalyse distinct activities...
  4. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
    ..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
  5. ncbi A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants
    Brook K Nelson
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 51:1126-36. 2007
    ..In addition, the Arabidopsis organelle marker lines can also be employed in plant cell biology teaching labs to demonstrate the distribution and dynamics of these organelles...
  6. ncbi Importing mitochondrial proteins: machineries and mechanisms
    Agnieszka Chacinska
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    Cell 138:628-44. 2009
    ..Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis...
  7. ncbi A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 429:841-7. 2004
    ..Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor...
  8. ncbi Genome-scale identification of Legionella pneumophila effectors using a machine learning approach
    David Burstein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    PLoS Pathog 5:e1000508. 2009
    ..pneumophila effectors, predicted over a hundred additional highly probable effectors, and shown the applicability of machine learning algorithms for the identification and characterization of bacterial pathogenesis determinants...
  9. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  10. ncbi Protein translocation across the bacterial cytoplasmic membrane
    Arnold J M Driessen
    Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and the Zernike Institute for Advanced Materials, University of Groningen, Haren, The Netherlands
    Annu Rev Biochem 77:643-67. 2008
    ..This review summarizes the present knowledge of the mechanism and structure of the Sec translocase, with a special emphasis on unresolved questions and topics of current research...
  11. ncbi The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    Y Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:652-6. 2001
    ..We propose that the Cdc48/p97-Ufd1-Npl4 complex extracts proteins from the ER membrane for cytosolic degradation...
  12. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    ..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
  13. ncbi Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome
    Thomas Becker
    Gene Center Munich and Center for Integrated Protein Science, Department of Chemistry and Biochemistry, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Science 326:1369-73. 2009
    ..This provides a structural basis for the activity of a solitary Sec complex in cotranslational protein translocation...
  14. ncbi Mechanisms of endocytosis
    Gary J Doherty
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Annu Rev Biochem 78:857-902. 2009
    ..We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes...
  15. ncbi Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
    ..enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?..
  16. ncbi Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
    Geoffrey K Feld
    Department of Chemistry, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 17:1383-90. 2010
    ..This structure provides insight into the mechanism of translocation-coupled protein unfolding...
  17. ncbi Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes
    William J Lucas
    Section of Plant Biology, College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
    Virology 344:169-84. 2006
    ....
  18. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002
    ..These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi...
  19. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  20. ncbi Coatomer-dependent protein delivery to lipid droplets
    Krishnakant G Soni
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 122:1834-41. 2009
    ..Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators...
  21. ncbi Biogenesis and function of multivesicular bodies
    Robert C Piper
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Annu Rev Cell Dev Biol 23:519-47. 2007
    ..However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks...
  22. ncbi Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors
    Xiaoxiao Pan
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 320:1651-4. 2008
    ..pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells...
  23. ncbi HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    J Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, USA
    Nat Med 7:1313-9. 2001
    ..Because the Tsg101 is recruited by small, conserved viral sequence motifs, agents that mimic these structures are potential inhibitors of the replication of these lethal human pathogens...
  24. ncbi A ribosome-associating factor chaperones tail-anchored membrane proteins
    Malaiyalam Mariappan
    Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 466:1120-4. 2010
    ..Thus, the Bat3 complex acts as a TMD-selective chaperone that effectively channels TA proteins to the TRC40 insertion pathway...
  25. ncbi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..Vpu co-localized with CD317 and inhibited these effects. Inhibition of Vpu function and consequent mobilization of tetherin's antiviral activity is a potential therapeutic strategy in HIV/AIDS...
  26. ncbi Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum
    K Plath
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 151:167-78. 2000
    ..Once bound to the Sec complex, the substrate is stripped of all cytosolic proteins, allowing it to subsequently be transported through the membrane channel without the interference of cytosolic binding partners...
  27. ncbi An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum
    Simone Spork
    Department of Parasitology, Philipps University Marburg, Germany
    Eukaryot Cell 8:1134-45. 2009
    ..Our data suggest that ERAD components have been "rewired" to provide a conduit for protein transport to the apicoplast...
  28. ncbi A role for lipid droplets in inter-membrane lipid traffic
    John K Zehmer
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Proteomics 9:914-21. 2009
    ..Based on this evidence, we present a model for how lipid droplets can distribute lipids to specific membrane compartments...
  29. ncbi SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  30. ncbi Nucleolus: the fascinating nuclear body
    Valentina Sirri
    Nuclei and Cell Cycle, CNRS, Universite Paris VI, Universite Paris VII, Institut Jacques Monod, 2 place Jussieu, 75251, Paris Cedex 05, France
    Histochem Cell Biol 129:13-31. 2008
    ..Perspectives on the evolution of this research area are proposed...
  31. ncbi SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
    Britta Mueller
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 175:261-70. 2006
    ..These results allow us to place SEL1L in the broader context of glycoprotein degradation, and imply the existence of multiple independent modes of extraction of misfolded substrates from the mammalian ER...
  32. ncbi Class 1 reversibly glycosylated polypeptides are plasmodesmal-associated proteins delivered to plasmodesmata via the golgi apparatus
    Guy Sagi
    Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Plant Cell 17:1788-800. 2005
    ..Treatment with the Golgi disrupting drug Brefeldin A inhibits Pd labeling by AtRGP2:GFP. Integrating these data, we conclude that (C1)RGPs are plasmodesmal-associated proteins delivered to plasmodesmata via the Golgi apparatus...
  33. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
    ..These observations suggest that retroviruses bud by appropriating cellular machinery normally used in the Vps pathway to form multivesicular bodies...
  34. ncbi Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
    Sumin Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:5851-6. 2010
    ..Thus, the yeast Orm proteins control membrane biogenesis by coordinating lipid homeostasis with protein quality control...
  35. ncbi Biogenesis of tail-anchored proteins: the beginning for the end?
    Catherine Rabu
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 122:3605-12. 2009
    ....
  36. ncbi Structural insight into the regulatory mechanisms of interactions of the flagellar type III chaperone FliT with its binding partners
    Katsumi Imada
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:8812-7. 2010
    ....
  37. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
    ..These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4...
  38. ncbi SUMO: a history of modification
    Ronald T Hay
    Centre for Biomolecular Sciences, School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland
    Mol Cell 18:1-12. 2005
    ..Here, the diverse effects of SUMO modification are discussed and models proposed to explain SUMO actions...
  39. ncbi Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer
    Karim Suwwan de Felipe
    Integrated Program in Cellular, Molecular and Biophysical Studies, New York, New York 10032, USA
    J Bacteriol 187:7716-26. 2005
    ..Our findings suggest that in L. pneumophila, interdomain HGT may have been a major mechanism for the acquisition of determinants of infection...
  40. ncbi Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1
    Yi Wei Chang
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 285:9962-70. 2010
    ..Moreover, GET3, GET4, and GET5 interacted genetically with molecular chaperone YDJ1, suggesting that chaperones might also be involved in the insertion of tail-anchored proteins...
  41. ncbi A translocation signal for delivery of oomycete effector proteins into host plant cells
    Stephen C Whisson
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Nature 450:115-8. 2007
    ..infestans genome. Identification of this class of proteins provides unparalleled opportunities to determine how oomycetes manipulate hosts to establish infection...
  42. ncbi Automated identification of pathways from quantitative genetic interaction data
    Alexis Battle
    Department of Computer Science, Stanford University, Stanford, CA 94305 9010, USA
    Mol Syst Biol 6:379. 2010
    ..Our approach should be readily applicable to the next generation of quantitative GI data sets, as assays become available for additional phenotypes and eventually higher-level organisms...
  43. ncbi Remote origins of tail-anchored proteins
    Nica Borgese
    Consiglio Nazionale delle Ricerche Institute of Neuroscience and Department of Pharmacology, Universita degli Studi di Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Traffic 11:877-85. 2010
    ..Thus, eukaryotes may have inherited the GET3 targeting pathway from our archeal ancestor, while the bacterial homologue may be exclusively dedicated to heavy metal resistance...
  44. ncbi Crossing the borders: poly(A)-binding proteins working on both sides of the fence
    Jean François Lemay
    Universite de Sherbrooke, Department of Biochemistry, Quebec, Canada
    RNA Biol 7:291-5. 2010
    ..Because 3' poly(A) tails can also act as a degradation mark via the exosome complex of 3'-5' exonucleases, we also discuss recent results that involve the nuclear PABP in posttranscriptional gene regulation...
  45. ncbi An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation
    Matthew P Klassen
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 66:710-23. 2010
    ..Together, these results suggest that arl-8 promotes a trafficking identity for presynaptic cargoes, facilitating their efficient transport by repressing premature self-association...
  46. ncbi Role of the C-terminal cytoplasmic domain of FlhA in bacterial flagellar type III protein export
    Tohru Minamino
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    J Bacteriol 192:1929-36. 2010
    ....
  47. ncbi Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes
    Daniel E Goldberg
    Howard Hughes Medical Institute, Washington University School of Medicine, Department of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Microbiol 8:617-21. 2010
    ..In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite...
  48. ncbi Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication
    Annette von dem Bussche
    Liver Research Center, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Hepatol 53:797-804. 2010
    ..The aim of the study was to determine whether the broad transcriptional repression is caused by endoplasmic reticulum (ER) stress...
  49. ncbi The human PDI family: versatility packed into a single fold
    Christian Appenzeller-Herzog
    Department of Molecular Biology, Universitetsparken 13, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Biochim Biophys Acta 1783:535-48. 2008
    ..Here, we primarily explore the diversity of cellular functions described for the human PDIs...
  50. ncbi Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes
    Dumaine Williams
    Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 180:375-87. 2008
    ....
  51. ncbi Mechanisms of type III protein export for bacterial flagellar assembly
    Tohru Minamino
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Biosyst 4:1105-15. 2008
    ....
  52. ncbi Amyloid precursor protein trafficking, processing, and function
    Gopal Thinakaran
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:29615-9. 2008
    ..This minireview summarizes salient features of APP trafficking and amyloidogenic processing and discusses the putative biological functions of APP...
  53. ncbi A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin
    Adi D Dubash
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA
    J Cell Sci 120:3989-98. 2007
    ..These data establish a previously uncharacterized role for the exchange factors Lsc/p115 RhoGEF and LARG in linking fibronectin signals to downstream RhoA activation...
  54. ncbi von Willebrand factor assembly and secretion
    J E Sadler
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Thromb Haemost 7:24-7. 2009
    ..Recent studies have identified some of the biochemical and structural properties that underlie these self-organizing behaviors...
  55. ncbi Differential gene expression in the distal tip endoderm of the embryonic mouse lung
    Yuru Liu
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Gene Expr Patterns 2:229-33. 2002
    ..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization...
  56. ncbi The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER
    Robert Ernst
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Mol Cell 36:28-38. 2009
    ..The assignment of a p97-associated ubiquitin processing function to YOD1 adds to our understanding of p97's role in the dislocation process...
  57. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
    ..Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located...
  58. ncbi Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane
    Eran Or
    Department of Cell Biology, Harvard Medical School, HHMI, Boston, MA 02115, USA
    EMBO J 21:4470-9. 2002
    ..Since SecA contains all characteristic motifs of a certain class of monomeric helicases, and since mutations in residues shared with the helicases abolish its translocation activity, SecA may function in a similar manner...
  59. ncbi SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
    Michael B Scher
    Howard Hughes Medical Institute, New York University Medical School, New York, New York 10016, USA
    Genes Dev 21:920-8. 2007
    ..This includes DNA damage induced by Etoposide and UV-irradiation, as well as overexpression of SirT3 itself...
  60. ncbi Arabidopsis GCP2 and GCP3 are part of a soluble gamma-tubulin complex and have nuclear envelope targeting domains
    Virginie Seltzer
    Institut de Biologie Moleculaire des Plantes, UPR2357 CNRS, Universite Louis Pasteur, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France
    Plant J 52:322-31. 2007
    ..We propose that regulated recruitment of soluble gamma-tubulin-containing complexes is responsible for nucleation at dispersed sites in plant cells and contributes to the formation and organization of the various MT arrays...
  61. ncbi Sel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar trafficking
    Hayley J Newton
    Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Victoria 3800, Australia
    Infect Immun 75:5575-85. 2007
    ..This investigation has further characterized the contribution of LpnE to L. pneumophila virulence and, more specifically, the importance of the SLR regions to LpnE function...
  62. ncbi A newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast
    Laurence Vernis
    Régulation de la Réplication de l ADN des Eucaryotes, UMR2027 CNRS Institut Curie, INSERM, Universite Paris Sud, Orsay, France
    PLoS ONE 4:e4376. 2009
    ..Our results are in favour of an oxidative stress-induced cell death in yeast that involves mitochondria and is controlled by the newly identified Dre2-Tah18 complex...
  63. ncbi Direct quantification of fusion rate reveals a distal role for AS160 in insulin-stimulated fusion of GLUT4 storage vesicles
    Li Jiang
    Joint Laboratory of Institute of Biophysics and Huazhong University of Science and Technology, National Laboratory of Biomacromolecules, Chinese Academy of Sciences, Beijing, China
    J Biol Chem 283:8508-16. 2008
    ....
  64. ncbi Protein transport into chloroplasts
    Hsou Min Li
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Annu Rev Plant Biol 61:157-80. 2010
    ..Multiple levels of control on protein transport into chloroplasts have evolved, including the development of two receptor subfamilies, one for ..
  65. ncbi N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation
    Mei Xue
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA
    J Biol Chem 279:45175-84. 2004
    ..Our results demonstrate for the first time that formation of a clustered activated receptor state precedes receptor phosphorylation, arrestin binding, and internalization...
  66. ncbi EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:23130-7. 2005
    ..pylori infection...
  67. ncbi Assembly and trafficking of human small conductance Ca2+-activated K+ channel SK3 are governed by different molecular domains
    Renza Roncarati
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, 37134 Verona, Italy
    Mol Cell Neurosci 28:314-25. 2005
    ..Thus, these two C-terminal regions of SK3 seem to contribute to assembly and trafficking of channels whereas the N-terminus is necessary for trafficking but not sufficient for oligomerization...
  68. ncbi Defective intracellular trafficking of uromodulin mutant isoforms
    Ilenia Bernascone
    Dulbecco Telethon Institute, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Traffic 7:1567-79. 2006
    ..protein processing in the secretory pathway and could demonstrate that although to different extent, all uromodulin mutations lead to defective ER to Golgi protein transport, suggesting a common pathogenetic mechanism in MCKD/FJHN.
  69. ncbi Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking
    David Nonis
    Department of Neurology, J W Goethe University Medical School, Frankfurt M, Germany
    Cell Signal 20:1725-39. 2008
    ..Functional studies demonstrated that ataxin-2 affects endocytic trafficking of the epidermal growth factor receptor (EGFR). Taken together, these data implicate ataxin-2 to play a role in endocytic receptor cycling...
  70. ncbi Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
    Jennifer S Ziegenfuss
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605 2324, USA
    Nature 453:935-9. 2008
    ..Thus, Draper seems to be an ancient immunoreceptor with an extracellular domain tuned to modified self, and an intracellular domain promoting phagocytosis through an ITAM-domain-SFK-Syk-mediated signalling cascade...
  71. ncbi mCLCA4 ER processing and secretion requires luminal sorting motifs
    Chunlei Huan
    Biomedical Sciences Department, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Am J Physiol Cell Physiol 295:C279-87. 2008
    ..Moreover, the mutated dileucine and diarginine signal sequences directed processing of a secreted form of enhanced green fluorescent protein in a manner consistent with the effects on mCLCA4...
  72. ncbi Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery
    Takumi Kakinuma
    Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan
    Exp Cell Res 298:388-98. 2004
    ..Our results suggest that p230, through its interaction with MACF1, provides the molecular link for transport of GPI-anchored proteins along the microtubule and actin cytoskeleton from the TGN to the cell periphery...
  73. ncbi Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF
    P Jaya Kausalya
    Institute of Molecular and Cell Biology, Epithelial Cell Biology Laboratory, Singapore 138673, Singapore
    Mol Biol Cell 15:5503-15. 2004
    ..Interactions with ZO-1 and ZO-2, in particular, may mediate recruitment of ARVCF to the plasma membrane and the nucleus, respectively, possibly in response to cell-cell adhesion cues...
  74. ncbi The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling
    Cosimo Commisso
    The Hospital for Sick Children, Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Mol Biol Cell 18:1-13. 2007
    ..Altogether, our data demonstrate that NHR domains can function in facilitating protein-protein interactions and in the case of Neuralized, mediate binding to its ubiquitination target, Delta...
  75. ncbi Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:44924-30. 2004
    ..Given the known sorting properties of BAP31, these findings suggest that BAP31 may play a role in regulating intracellular trafficking of CD11b/CD18 in neutrophils...
  76. ncbi Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    Makoto Hiromura
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 279:53407-18. 2004
    ..This observation will facilitate the design of specific inhibitors for Akt, a core intracellular survival factor underlying various human neoplastic diseases...
  77. ncbi Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane
    Sophie Chen
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Traffic 7:1503-17. 2006
    ....
  78. ncbi CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P
    Julie Stirling
    Marie Curie Research Institute, Oxted RH8 0TL, United Kingdom
    Mol Biol Cell 17:413-26. 2006
    ....
  79. ncbi Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation
    Yoon Kwang Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:7850-5. 2006
    ..This pathway may contribute to recently described proliferative functions of LRH-1...
  80. ncbi Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor
    Brian W Jones
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 280:38346-54. 2005
    ..The results show conclusively that receptor dephosphorylation can take place on the plasma membrane and that beta-arrestin binding is critical for desensitization and internalization...
  81. ncbi Prolonged display or rapid internalization of the IgG-binding protein ZZ anchored to the surface of cells using the diphtheria toxin T domain
    P Nizard
    , CEA-Saclay, 91191 Gif sur Yvette Cedex, France
    Protein Eng 14:439-46. 2001
    ..Thus, depending on the cell type, soluble proteins may be anchored to the surface of cells by the T domain for an extended time or directed towards an internalization pathway...
  82. ncbi Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway
    Catrin Williams
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 120:3941-51. 2007
    ..Our data suggest a role for INPP5B in retrograde ERGIC-to-ER transport and imply that it has functions distinct from those of OCRL1 within both the secretory and endocytic pathways...
  83. ncbi Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2
    Nadja Jung
    Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 179:1497-510. 2007
    ..Synaptotagmin-binding-defective UNC-41B is unable to rescue paralysis in C. elegans stonin mutant animals, suggesting that the mechanism of stonin-mediated SV cargo recognition is conserved from worms to mammals...
  84. ncbi Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G
    Masaki Saito
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6 3, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Biochem J 392:75-81. 2005
    ..1G, but not 4.1G-CTD. These data indicate that 4.1G facilitates the cell-surface localization of PTHR through its interaction with the C-terminus of the receptor, resulting in the potentiation of PTHR-mediated signal transduction...
  85. ncbi Dual role of the cysteine-string domain in membrane binding and palmitoylation-dependent sorting of the molecular chaperone cysteine-string protein
    Jennifer Greaves
    Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Mol Biol Cell 17:4748-59. 2006
    ..These results reveal a dual function of the cysteine-string domain: initial membrane binding and palmitoylation-dependent sorting...
  86. ncbi IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase
    David R Hodge
    Laboratory of Cancer Prevention, Cancer Stem Cell Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Cancer Genomics Proteomics 4:387-98. 2007
    ....
  87. ncbi Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling
    Christelle Langlet
    Laboratoire de Chimie Biologique et de la Nutrition, Faculte de Medecine, Universite Libre de Bruxelles, Bruxelles B 1070, Belgium
    J Biol Chem 280:28034-43. 2005
    ..Receptor recovery was blocked by monensin, an endosome inhibitor...
  88. ncbi Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane
    Ellen Knuepfer
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
    Mol Microbiol 58:1039-53. 2005
    ..This study characterizes elements involved in the tight but transient binding of PfEMP3 to Maurer's clefts and shows that the same elements are necessary for correct assembly under the erythrocyte membrane...
  89. ncbi Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
    Li Ping Sun
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Biol Chem 280:26483-90. 2005
    ..This hexapeptide acts as a sterol-regulated ER sorting signal. These studies define the biochemical parameters responsible for regulated sorting of an ER membrane protein into COPII-coated vesicles...
  90. ncbi Structural determinants of alpha4beta2 nicotinic acetylcholine receptor trafficking
    Xiao Qin Ren
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:6676-86. 2005
    ..Collectively, our results identify, for the first time, residues within AChR subunits that are essential structural determinants of alpha4beta2 AChR ER export...
  91. ncbi The H,K-ATPase beta subunit as a model to study the role of N-glycosylation in membrane trafficking and apical sorting
    Olga Vagin
    Department of Physiology, School of Medicine, UCLA, Los Angeles, California, USA
    J Biol Chem 279:39026-34. 2004
    ....
  92. ncbi The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast
    W E Gall
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    Curr Biol 10:1349-58. 2000
    ..Removal of the clathrin coat in vitro requires the uncoating ATPase Hsc70 and its DnaJ cofactor auxilin. To date, a requirement for auxilin and Hsc70 in clathrin function in vivo has not been demonstrated...
  93. ncbi Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358
    Hisato Saitoh
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 277:4755-63. 2002
    ....
  94. ncbi An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export
    C Votsmeier
    Department of Molecular Genetics, Max Planck Institute for Biophysical Chemistry, D 37070 Gottingen, Germany
    EMBO J 20:6742-50. 2001
    ..Our study demonstrates for the first time that, in yeast, a di-acidic sequence motif can act as a sorting signal for cargo selection during the formation of transport vesicles at the ER by direct binding to COPII component(s)...
  95. ncbi Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association
    Jean Pierre Vilardaga
    Department of Pharmacology, Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg D 97078, Germany
    J Biol Chem 277:8121-9. 2002
    ..Determinants in the receptor's core (Asn-289 and Lys-382) appear to regulate internalization of the receptor/beta-arrestin complex toward early endocytic endosomes during the initial step of endocytosis...
  96. ncbi Mitochondrial protein import: molecular basis of the ATP-dependent interaction of MtHsp70 with Tim44
    Fernando Moro
    Institut für Physiologische Chemie der Universität München, Butenandtstrasse 5, 81377 Munich, Germany
    J Biol Chem 277:6874-80. 2002
    ....
  97. ncbi Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain
    Jianlin Chu
    Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 387 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Biol Chem 277:7587-97. 2002
    ..These results provide evidence for negative cross-talk between Notch and AP-1, which may have important consequences for controlling diverse biological processes...
  98. ncbi Essential cytoplasmic domains in the Escherichia coli TatC protein
    Stuart C H Allen
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Biol Chem 277:10362-6. 2002
    ..The data point to two essential cytoplasmic domains on the TatC protein that are essential for export...
  99. ncbi PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain
    Masayuki Tanemoto
    Department of Pharmacology II, Graduate School of Medicine A7, Osaka University, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    Neuron 34:387-97. 2002
    ..1/PSD-95 were suppressed promptly and reversibly by PKA activation. Because the Kir5.1/PSD-95 complex was detected in the brain, this functional brain K+ channel is potentially a novel physiological target of PKA-mediated signaling...
  100. ncbi Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library
    J A Leeds
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Mol Biol 313:181-95. 2001
    ..This work demonstrates the utility of combining in vivo genetic tools with computational systems for understanding membrane protein structure and assembly...
  101. ncbi Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin
    M Sohda
    Department of Biochemistry, School of Medicine and Advanced Materials Institute, Fukuoka University, Jonan ku, Fukuoka 814 0180, Japan
    J Biol Chem 276:45298-306. 2001
    ..Overexpression of the COOH-terminal domain of GCP60 caused disassembly of the Golgi structure and blocked protein transport from the endoplasmic reticulum to the Golgi...

Research Grants83

  1. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2010
    ..build an outer segment?" The proposed research examines aspects of integral membrane and peripheral membrane protein transport from photoreceptor inner segment (site of biosynthesis) to the outer segment (site of phototransduction)...
  2. STRUCTURE, BIOSYNTHESIS AND FUNCTION OF GLYCOPROTEINS
    Stuart Kornfeld; Fiscal Year: 2007
    ..Defects in this intracellular protein transport pathway give rise to severe lysosomal storage diseases...
  3. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2010
    The goal of this proposal is to understand the related processes of secretory protein transport and lipid metabolism in African trypanosomes. These processes have been defined primarily in vertebrate tissue culture cells and yeast...
  4. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  5. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    KARLETT PARRA; Fiscal Year: 2009
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  6. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  7. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
    ....
  8. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    ....
  9. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2011
    ..build an outer segment?" The proposed research examines aspects of integral membrane and peripheral membrane protein transport from photoreceptor inner segment (site of biosynthesis) to the outer segment (site of phototransduction)...
  10. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2000
    ..carrying mutations in the clathrin heavy chain subunit revealed that clathrin participates in selective protein transport processes at the plasma membrane and the Golgi complex: endocytosis of the mating pheromone receptors, ..
  11. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 1993
    ..in the clathrin heavy chain subunit revealed that clathrin plays an important role in several selective protein transport steps, including selective retention of Golgi membrane proteins, receptor-mediated endocytosis of the mating ..
  12. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2010
    ..This complexity generates several fundamental questions concerning intracellular protein transport and endoplasmic reticulum (ER) quality control function that link directly to clinical disease...
  13. Clathrin adaptor function at the trans Golgi network and endosomes
    Gregory Payne; Fiscal Year: 2007
    ..cerevisiae indicate that clathrin coated vesicles (ccv) participate in evolutionarily conserved protein transport between the TGN and endosomes...
  14. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2010
    ..This complexity generates several fundamental questions concerning intracellular protein transport and endoplasmic reticulum (ER) quality control function that link directly to clinical disease...
  15. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
    ..abstract_text> ..
  16. Intraflagellar Transport Proteins in Mice
    Gregory J Pazour; Fiscal Year: 2011
    ..Understanding the mechanisms of ciliary membrane protein transport will provide insight into the etiology of many ciliary diseases since the sensory functions of cilia depend ..
  17. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory S Payne; Fiscal Year: 2010
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  18. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2009
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  19. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2009
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  20. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2007
    ..abstract_text> ..
  21. CYTOPLASMIC FUCOSYLATION
    Christopher West; Fiscal Year: 1993
    ..proliferation rate, cell sorting, pseudoplasmodial migration, spore coat formation, spore germination, and protein transport rate, in the cellular slime mold Dictyostelium discoideum...
  22. ISOPRENYLATED GTP-BINDING PROTEINS AND CELL GROWTH
    WILLIAM MALTESE; Fiscal Year: 1999
    ....
  23. Ubiquitin-like Small Archaeal Protein Modification (SAMPylation)
    Julie A Maupin Furlow; Fiscal Year: 2010
    ..Advancing our understanding of these processes will greatly assist in targeting proteasomes and Ub/Ubl-conjugation pathways for the development of new anti-cancer and anti-inflammatory drugs. ..
  24. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ....
  25. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2009
    ....
  26. ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
    DANIEL KLIONSKY; Fiscal Year: 2002
    ..The investigator will use yeast as a model system to study these problems since the pathways used for protein transport appear to be very similar to those in animal cells, and in addition yeast are amenable to useful genetic ..
  27. Protein targeting in vertebrate photoreceptors
    Sheila A Baker; Fiscal Year: 2010
    ..Elucidating the mechanisms controlling these processes is essential for developing therapeutic interventions. ..
  28. The Role of ER-stress and pH in Fluorosis
    John D Bartlett; Fiscal Year: 2010
    ..These data corroborate prior studies demonstrating F-induced ER distention (2) and defective ER to Golgi protein transport (3)...
  29. The Role of ER-stress and pH in Fluorosis
    John Bartlett; Fiscal Year: 2009
    ..These data corroborate prior studies demonstrating F-induced ER distention (2) and defective ER to Golgi protein transport (3)...
  30. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..
  31. MECHANISTIC STUDIES ON A CO2+ DEPENDENT MAP FROM E COLI
    RICHARD HOLZ; Fiscal Year: 2002
    ....