protein transport

Summary

Summary: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Top Publications

  1. doi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
  2. ncbi A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants
    Brook K Nelson
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 51:1126-36. 2007
  3. pmc One step at a time: endoplasmic reticulum-associated degradation
    Shruthi S Vembar
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Rev Mol Cell Biol 9:944-57. 2008
  4. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
  5. doi The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    Camilla Raiborg
    Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Nature 458:445-52. 2009
  6. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
  7. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
  8. pmc Importing mitochondrial proteins: machineries and mechanisms
    Agnieszka Chacinska
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    Cell 138:628-44. 2009
  9. ncbi SUMO: a history of modification
    Ronald T Hay
    Centre for Biomolecular Sciences, School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland
    Mol Cell 18:1-12. 2005
  10. pmc Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
    Stefan Pukatzki
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:1528-33. 2006

Detail Information

Publications316 found, 100 shown here

  1. doi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..Vpu co-localized with CD317 and inhibited these effects. Inhibition of Vpu function and consequent mobilization of tetherin's antiviral activity is a potential therapeutic strategy in HIV/AIDS...
  2. ncbi A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants
    Brook K Nelson
    Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996 0840, USA
    Plant J 51:1126-36. 2007
    ..In addition, the Arabidopsis organelle marker lines can also be employed in plant cell biology teaching labs to demonstrate the distribution and dynamics of these organelles...
  3. pmc One step at a time: endoplasmic reticulum-associated degradation
    Shruthi S Vembar
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Rev Mol Cell Biol 9:944-57. 2008
    ..Here, we summarize our current understanding of each step during ERAD, with emphasis on the factors that catalyse distinct activities...
  4. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
    ....
  5. doi The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    Camilla Raiborg
    Centre for Cancer Biomedicine, Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Nature 458:445-52. 2009
    ..The involvement of the ESCRT machinery in suppressing diseases such as cancer, neurodegeneration and infections underscores its importance to the cell...
  6. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  7. pmc PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    Cristofol Vives-Bauza
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:378-83. 2010
    ..Thus by impairing this process, mutations in either Parkin or PINK1 may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease...
  8. pmc Importing mitochondrial proteins: machineries and mechanisms
    Agnieszka Chacinska
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, 79104 Freiburg, Germany
    Cell 138:628-44. 2009
    ..Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis...
  9. ncbi SUMO: a history of modification
    Ronald T Hay
    Centre for Biomolecular Sciences, School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland
    Mol Cell 18:1-12. 2005
    ..Here, the diverse effects of SUMO modification are discussed and models proposed to explain SUMO actions...
  10. pmc Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system
    Stefan Pukatzki
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:1528-33. 2006
    ..Thus, the genes encoding the VAS-related, type VI secretion system likely play an important conserved function in microbial pathogenesis and represent an additional class of targets for vaccine and antimicrobial drug-based therapies...
  11. ncbi Local, efflux-dependent auxin gradients as a common module for plant organ formation
    Eva Benkova
    Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, 72076 Tubingen, Germany
    Cell 115:591-602. 2003
    ..Our results suggest that PIN-dependent, local auxin gradients represent a common module for formation of all plant organs, regardless of their mature morphology or developmental origin...
  12. pmc Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    Elena Ziviani
    Department of Biomedical Sciences, Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 107:5018-23. 2010
    ..We hypothesize that Mfn ubiquitination may provide a mechanism by which terminally damaged mitochondria are labeled and sequestered for degradation by autophagy...
  13. ncbi Integrins: masters and slaves of endocytic transport
    Patrick T Caswell
    Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, G61 3BX, Scotland
    Nat Rev Mol Cell Biol 10:843-53. 2009
    ..Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis...
  14. ncbi Protein translocation across the bacterial cytoplasmic membrane
    Arnold J M Driessen
    Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and the Zernike Institute for Advanced Materials, University of Groningen, Haren, The Netherlands
    Annu Rev Biochem 77:643-67. 2008
    ..This review summarizes the present knowledge of the mechanism and structure of the Sec translocase, with a special emphasis on unresolved questions and topics of current research...
  15. pmc Synaptic AMPA receptor plasticity and behavior
    Helmut W Kessels
    Department of Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Neuron 61:340-50. 2009
    ..We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models...
  16. doi Nonproteolytic functions of ubiquitin in cell signaling
    Zhijian J Chen
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 33:275-86. 2009
    ..Recent advances in understanding ubiquitination in protein kinase activation and DNA repair are discussed to illustrate the nonproteolytic functions of ubiquitin in cell signaling...
  17. ncbi A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    Maxence V Nachury
    Genentech, Inc, South San Francisco, CA 94080, USA
    Cell 129:1201-13. 2007
    ..Conversely, preventing Rab8(GTP) production blocks ciliation in cells and yields characteristic BBS phenotypes in zebrafish. Our data reveal that BBS may be caused by defects in vesicular transport to the cilium...
  18. ncbi Prions hijack tunnelling nanotubes for intercellular spread
    Karine Gousset
    Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Cell Biol 11:328-36. 2009
    ..We therefore propose that TNTs are involved in the spreading of PrP(Sc) within neurons in the CNS and from the peripheral site of entry to the PNS by neuroimmune interactions with dendritic cells...
  19. pmc The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia
    Hua Jin
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
    Cell 141:1208-19. 2010
    ..Thus, we propose that trafficking of BBSome cargoes to cilia entails the coupling of BBSome coat polymerization to the recognition of sorting signals by the BBSome...
  20. ncbi The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    Yoshiharu Kawaguchi
    Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA
    Cell 115:727-38. 2003
    ..These findings identify HDAC6 as a crucial player in the cellular management of misfolded protein-induced stress...
  21. pmc Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?
    Frederic Boyer
    CEA, iRTSV, Laboratoire Biologie, Informatique et Mathématiques, Grenoble, France
    BMC Genomics 10:104. 2009
    ..By combining comparative and phylogenetic approaches using more than 500 prokaryotic genomes, we characterized the global T6SS genetic structure in terms of conservation, evolution and genomic organization...
  22. doi Mechanisms of regulated unconventional protein secretion
    Walter Nickel
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    Nat Rev Mol Cell Biol 10:148-55. 2009
    ....
  23. ncbi Endocytosis and intracellular trafficking of ErbBs
    Alexander Sorkin
    Department of Pharmacology, University of Colorado Denver Anschutz Medical Center, Aurora, Colorado 80045 0508, USA
    Exp Cell Res 315:683-96. 2009
    ..However, these ErbBs are internalized and targeted to lysosomes less efficiently than EGFR. When overexpressed endocytosis-impaired ErbBs may inhibit the internalization and degradation of EGFR...
  24. pmc Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia
    John B Wallingford
    Howard Hughes Medical Institute, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Genes Dev 25:201-13. 2011
    ....
  25. doi Mitochondrial protein import: from proteomics to functional mechanisms
    Oliver Schmidt
    Institut fur Biochemie und Molekularbiologie, ZBMZ, Universitat Freiburg, Stefan Meier Strabetae 17, 79104 Freiburg, Germany
    Nat Rev Mol Cell Biol 11:655-67. 2010
    ..Protein translocases do not function as independent units but are integrated into dynamic networks and are connected to machineries that function in bioenergetics, mitochondrial morphology and coupling to the endoplasmic reticulum...
  26. ncbi The Wnt signaling pathway in development and disease
    Catriona Y Logan
    Department of Developmental Biology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 20:781-810. 2004
    ..The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions...
  27. pmc Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation
    Jing Wu
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 147:615-28. 2011
    ..Genetic deletion of Arc reduces Aβ load in a transgenic mouse model of AD. In concert with the finding that patients with AD can express anomalously high levels of Arc, we hypothesize that Arc participates in the pathogenesis of AD...
  28. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development...
  29. ncbi Intracellular functions of N-linked glycans
    A Helenius
    Institute of Biochemistry, , , , Switzerland
    Science 291:2364-9. 2001
    ..The division of synthesis and processing between the ER and the Golgi complex represents an evolutionary adaptation that allows efficient exploitation of the potential of oligosaccharides...
  30. pmc Nuclear trafficking of the epidermal growth factor receptor family membrane proteins
    Y N Wang
    Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:3997-4006. 2010
    ..Understanding the trafficking mechanisms as to how RTKs are transported from the cell surface to the nucleus will significantly contribute to understanding the functions of the nuclear RTKs...
  31. pmc Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
    G M Cereghetti
    Dulbecco Telethon Institute, Padua, Italy
    Proc Natl Acad Sci U S A 105:15803-8. 2008
    ..Thus, fragmentation of depolarized mitochondria depends on a loop involving sustained Ca(2+) rise, activation of calcineurin, and dephosphorylation of Drp1 and its translocation to the organelle...
  32. pmc Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13461-6. 2005
    ..Consequently, reduced receptor expression in the human brain may increase Abeta production and plaque formation and promote spontaneous AD...
  33. ncbi Exosomes: from biogenesis and secretion to biological function
    Sascha Keller
    German Cancer Research Center DKFZ, Tumor Immunology Program, D010 TP3, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Immunol Lett 107:102-8. 2006
    ....
  34. ncbi Exosomes: a common pathway for a specialized function
    Guillaume van Niel
    Institut Curie, CNRS UMR144, 75248 Paris Cedex, France
    J Biochem 140:13-21. 2006
    ..These findings open up new therapeutic and diagnostic strategies...
  35. ncbi A bacterial virulence protein suppresses host innate immunity to cause plant disease
    Kinya Nomura
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA
    Science 313:220-3. 2006
    ..HopM1 mediates the destruction of AtMIN7 via the host proteasome. Our results illustrate a strategy by which a bacterial pathogen exploits the host proteasome to subvert host immunity and causes infection in plants...
  36. ncbi Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
    Patrick T Caswell
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Dev Cell 13:496-510. 2007
    ..These data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix...
  37. ncbi Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method
    Christopher J Tonkin
    Plant Cell Biology Research Centre, School of Botany, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Biochem Parasitol 137:13-21. 2004
    ..falciparum proteins...
  38. pmc Cryo-EM structure of the ribosome-SecYE complex in the membrane environment
    Jens Frauenfeld
    Gene Center, Department for Biochemistry, University of Munich, Munich, Germany
    Nat Struct Mol Biol 18:614-21. 2011
    ..On the basis of our map and molecular dynamics simulations, we present a model of a signal anchor-gated PCC in the membrane...
  39. pmc The type VI secretion toolkit
    Eric Cascales
    Laboratoire d Ingenierie des Systemes Macromoleculaires, IBSM, Centre National de la Recherche Scientifique, Marseille, France
    EMBO Rep 9:735-41. 2008
    ..This review provides an overview of our current knowledge about type VI secretion, focusing on gene regulation, components of the secretion machine, substrate secretion and the cellular consequences for the host cell...
  40. ncbi The genome of the African trypanosome Trypanosoma brucei
    Matthew Berriman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Science 309:416-22. 2005
    ..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
  41. pmc Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors
    Xiaoxiao Pan
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 320:1651-4. 2008
    ..pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells...
  42. ncbi Protein sorting receptors in the early secretory pathway
    Julia Dancourt
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Annu Rev Biochem 79:777-802. 2010
    ..Our current understanding of the molecular mechanisms underlying cargo receptor function are described...
  43. pmc Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
    Thomas Wollert
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nature 464:864-9. 2010
    ..The observations explain how the ESCRTs direct membrane budding and scission from the cytoplasmic side of the bud without being consumed in the reaction...
  44. ncbi A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 429:841-7. 2004
    ..Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor...
  45. pmc Comprehensive identification of protein substrates of the Dot/Icm type IV transporter of Legionella pneumophila
    Wenhan Zhu
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 6:e17638. 2011
    ..Thus, our efforts have identified a large number of novel substrates of the Dot/Icm system and have revealed the diverse features recognizable by this protein transporter...
  46. pmc Identification of a tumour suppressor network opposing nuclear Akt function
    Lloyd C Trotman
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 441:523-7. 2006
    ..Our results demonstrate that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment...
  47. pmc Coordinated protein sorting, targeting and distribution in polarized cells
    Ira Mellman
    Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Rev Mol Cell Biol 9:833-45. 2008
    ..The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states...
  48. pmc Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments
    Patrick T Caswell
    Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 183:143-55. 2008
    ..We conclude that RCP provides a scaffold that promotes the physical association and coordinate trafficking of alpha5beta1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices...
  49. pmc The mitochondrial p53 pathway
    Angelina V Vaseva
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    Biochim Biophys Acta 1787:414-20. 2009
    ..Our review will discuss these studies, focusing on recent advances in the field...
  50. ncbi A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    X Cao
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
    Science 293:115-20. 2001
    ..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
  51. pmc Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions
    Pankaj Dhonukshe
    Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands
    Nature 456:962-6. 2008
    ..It also highlights the link between endocytosis-dependent polarity of individual cells and auxin distribution-dependent cell fate establishment for multicellular patterning...
  52. pmc Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins
    Yun Wah Lam
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Curr Biol 17:749-60. 2007
    ....
  53. pmc Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?
    Maxence V Nachury
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305 5345, USA
    Annu Rev Cell Dev Biol 26:59-87. 2010
    ..Finally, some proteins need to exit from cilia, and ubiquitination may regulate this step. The stage is now set to dissect the interplay between signaling and regulated trafficking to and from cilia...
  54. ncbi Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
    Shyra J Gardai
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Biol Chem 279:21085-95. 2004
    ....
  55. pmc Genome-scale identification of Legionella pneumophila effectors using a machine learning approach
    David Burstein
    Department of Cell Research and Immunology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    PLoS Pathog 5:e1000508. 2009
    ..pneumophila effectors, predicted over a hundred additional highly probable effectors, and shown the applicability of machine learning algorithms for the identification and characterization of bacterial pathogenesis determinants...
  56. ncbi Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
    William Ju
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, 1201 Welch Road, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 7:244-53. 2004
    ....
  57. ncbi PML regulates p53 stability by sequestering Mdm2 to the nucleolus
    Rosa Bernardi
    Cancer Biology and Genetics Program, Department of Pathology and Medicine, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Cell Biol 6:665-72. 2004
    ..These findings demonstrate an unexpected role of PML in the nucleolar network for tumour suppression...
  58. pmc ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
    Ragna Sannerud
    Laboratory of Membrane Trafficking, Center for Human Genetics, Catholic University of Leuven, Leuven, Belgium
    Proc Natl Acad Sci U S A 108:E559-68. 2011
    ..It thereby provides a novel avenue to interfere with Aβ production through a selective modulation of the distinct endosomal transport routes used by BACE1 or APP...
  59. pmc Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
    Mathieu Dubé
    Laboratory of Human Retrovirology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000856. 2010
    ....
  60. pmc A FAM21-containing WASH complex regulates retromer-dependent sorting
    Timothy S Gomez
    Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Dev Cell 17:699-711. 2009
    ....
  61. pmc A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
    Hanna Tukachinsky
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 191:415-28. 2010
    ..Our results support a simple mechanism in which Hh signals at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA...
  62. pmc Routes, destinations and delays: recent advances in AMPA receptor trafficking
    Jeremy M Henley
    MRC Centre for Synaptic Plasticity, School of Biochemistry, University of Bristol, University Walk, Bristol, UK, BS8 1TD
    Trends Neurosci 34:258-68. 2011
    ..Here, we review recent findings that have provided new insights into AMPAR trafficking and that might lead to the development of novel therapeutic strategies...
  63. pmc SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors
    Paul Temkin
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158, USA
    Nat Cell Biol 13:715-21. 2011
    ..The present results identify a role for retromer in endocytic trafficking of signalling receptors, in regulating a receptor-linked signalling pathway, and in mediating direct endosome-to-plasma membrane traffic...
  64. doi Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
    Timothy J Knowles
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, Edgbaston, Birmingham, UK
    Nat Rev Microbiol 7:206-14. 2009
    ..Here, we discuss how these structures illuminate the mechanisms responsible for the biogenesis of outer membrane proteins...
  65. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  66. ncbi Dissection of a type VI secretion system in Edwardsiella tarda
    Jun Zheng
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Mol Microbiol 66:1192-206. 2007
    ..The interaction between EvpC and EvpP was demonstrated. Lastly, two proteins (EvpD and EvpJ) are not required for the T6SS-dependent secretion...
  67. ncbi The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    Y Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:652-6. 2001
    ..We propose that the Cdc48/p97-Ufd1-Npl4 complex extracts proteins from the ER membrane for cytosolic degradation...
  68. pmc Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome
    Thomas Becker
    Gene Center Munich and Center for Integrated Protein Science, Department of Chemistry and Biochemistry, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Science 326:1369-73. 2009
    ..This provides a structural basis for the activity of a solitary Sec complex in cotranslational protein translocation...
  69. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    ..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
  70. pmc Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
    ..enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?..
  71. doi Mechanisms of endocytosis
    Gary J Doherty
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Annu Rev Biochem 78:857-902. 2009
    ..We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes...
  72. pmc Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers
    Geoffrey K Feld
    Department of Chemistry, University of California, Berkeley, California, USA
    Nat Struct Mol Biol 17:1383-90. 2010
    ..This structure provides insight into the mechanism of translocation-coupled protein unfolding...
  73. ncbi ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
    Jingshi Shen
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 3:99-111. 2002
    ..These results suggest that BiP retains ATF6 in the ER by inhibiting its GLSs and that dissociation of BiP during ER stress allows ATF6 to be transported to the Golgi...
  74. ncbi Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomes
    William J Lucas
    Section of Plant Biology, College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
    Virology 344:169-84. 2006
    ....
  75. pmc Coatomer-dependent protein delivery to lipid droplets
    Krishnakant G Soni
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 122:1834-41. 2009
    ..Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators...
  76. pmc Biogenesis and function of multivesicular bodies
    Robert C Piper
    Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Annu Rev Cell Dev Biol 23:519-47. 2007
    ..However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks...
  77. pmc A ribosome-associating factor chaperones tail-anchored membrane proteins
    Malaiyalam Mariappan
    Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 466:1120-4. 2010
    ..Thus, the Bat3 complex acts as a TMD-selective chaperone that effectively channels TA proteins to the TRC40 insertion pathway...
  78. ncbi HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    J Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, USA
    Nat Med 7:1313-9. 2001
    ..Because the Tsg101 is recruited by small, conserved viral sequence motifs, agents that mimic these structures are potential inhibitors of the replication of these lethal human pathogens...
  79. pmc Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum
    K Plath
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 151:167-78. 2000
    ..Once bound to the Sec complex, the substrate is stripped of all cytosolic proteins, allowing it to subsequently be transported through the membrane channel without the interference of cytosolic binding partners...
  80. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  81. pmc A role for lipid droplets in inter-membrane lipid traffic
    John K Zehmer
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Proteomics 9:914-21. 2009
    ..Based on this evidence, we present a model for how lipid droplets can distribute lipids to specific membrane compartments...
  82. pmc An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum
    Simone Spork
    Department of Parasitology, Philipps University Marburg, Germany
    Eukaryot Cell 8:1134-45. 2009
    ..Our data suggest that ERAD components have been "rewired" to provide a conduit for protein transport to the apicoplast...
  83. pmc Nucleolus: the fascinating nuclear body
    Valentina Sirri
    Nuclei and Cell Cycle, CNRS, Universite Paris VI, Universite Paris VII, Institut Jacques Monod, 2 place Jussieu, 75251, Paris Cedex 05, France
    Histochem Cell Biol 129:13-31. 2008
    ..Perspectives on the evolution of this research area are proposed...
  84. pmc SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
    Britta Mueller
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Cell Biol 175:261-70. 2006
    ..These results allow us to place SEL1L in the broader context of glycoprotein degradation, and imply the existence of multiple independent modes of extraction of misfolded substrates from the mammalian ER...
  85. pmc Class 1 reversibly glycosylated polypeptides are plasmodesmal-associated proteins delivered to plasmodesmata via the golgi apparatus
    Guy Sagi
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Plant Cell 17:1788-800. 2005
    ..Treatment with the Golgi disrupting drug Brefeldin A inhibits Pd labeling by AtRGP2:GFP. Integrating these data, we conclude that (C1)RGPs are plasmodesmal-associated proteins delivered to plasmodesmata via the Golgi apparatus...
  86. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
    ..These observations suggest that retroviruses bud by appropriating cellular machinery normally used in the Vps pathway to form multivesicular bodies...
  87. doi Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes
    Daniel E Goldberg
    Howard Hughes Medical Institute, Washington University School of Medicine, Department of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Microbiol 8:617-21. 2010
    ..In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite...
  88. ncbi Crossing the borders: poly(A)-binding proteins working on both sides of the fence
    Jean François Lemay
    Universite de Sherbrooke, Department of Biochemistry, Quebec, Canada
    RNA Biol 7:291-5. 2010
    ..Because 3' poly(A) tails can also act as a degradation mark via the exosome complex of 3'-5' exonucleases, we also discuss recent results that involve the nuclear PABP in posttranscriptional gene regulation...
  89. doi Remote origins of tail-anchored proteins
    Nica Borgese
    Consiglio Nazionale delle Ricerche Institute of Neuroscience and Department of Pharmacology, Universita degli Studi di Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Traffic 11:877-85. 2010
    ..Thus, eukaryotes may have inherited the GET3 targeting pathway from our archeal ancestor, while the bacterial homologue may be exclusively dedicated to heavy metal resistance...
  90. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
    ..These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4...
  91. pmc Automated identification of pathways from quantitative genetic interaction data
    Alexis Battle
    Department of Computer Science, Stanford University, Stanford, CA 94305 9010, USA
    Mol Syst Biol 6:379. 2010
    ..Our approach should be readily applicable to the next generation of quantitative GI data sets, as assays become available for additional phenotypes and eventually higher-level organisms...
  92. pmc An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation
    Matthew P Klassen
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 66:710-23. 2010
    ..Together, these results suggest that arl-8 promotes a trafficking identity for presynaptic cargoes, facilitating their efficient transport by repressing premature self-association...
  93. ncbi A translocation signal for delivery of oomycete effector proteins into host plant cells
    Stephen C Whisson
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Nature 450:115-8. 2007
    ..infestans genome. Identification of this class of proteins provides unparalleled opportunities to determine how oomycetes manipulate hosts to establish infection...
  94. pmc Amyloid precursor protein trafficking, processing, and function
    Gopal Thinakaran
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:29615-9. 2008
    ..This minireview summarizes salient features of APP trafficking and amyloidogenic processing and discusses the putative biological functions of APP...
  95. pmc Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer
    Karim Suwwan de Felipe
    Integrated Program in Cellular, Molecular and Biophysical Studies, New York, New York 10032, USA
    J Bacteriol 187:7716-26. 2005
    ..Our findings suggest that in L. pneumophila, interdomain HGT may have been a major mechanism for the acquisition of determinants of infection...
  96. pmc Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication
    Annette von dem Bussche
    Liver Research Center, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Hepatol 53:797-804. 2010
    ..The aim of the study was to determine whether the broad transcriptional repression is caused by endoplasmic reticulum (ER) stress...
  97. pmc Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
    Sumin Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:5851-6. 2010
    ..Thus, the yeast Orm proteins control membrane biogenesis by coordinating lipid homeostasis with protein quality control...
  98. ncbi The human PDI family: versatility packed into a single fold
    Christian Appenzeller-Herzog
    Department of Molecular Biology, Universitetsparken 13, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Biochim Biophys Acta 1783:535-48. 2008
    ..Here, we primarily explore the diversity of cellular functions described for the human PDIs...
  99. ncbi Mechanisms of type III protein export for bacterial flagellar assembly
    Tohru Minamino
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Biosyst 4:1105-15. 2008
    ....
  100. pmc Structural insight into the regulatory mechanisms of interactions of the flagellar type III chaperone FliT with its binding partners
    Katsumi Imada
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:8812-7. 2010
    ....
  101. pmc Biogenesis of tail-anchored proteins: the beginning for the end?
    Catherine Rabu
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    J Cell Sci 122:3605-12. 2009
    ....

Research Grants84

  1. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2010
    ..build an outer segment?" The proposed research examines aspects of integral membrane and peripheral membrane protein transport from photoreceptor inner segment (site of biosynthesis) to the outer segment (site of phototransduction)...
  2. STRUCTURE, BIOSYNTHESIS AND FUNCTION OF GLYCOPROTEINS
    Stuart Kornfeld; Fiscal Year: 2007
    ..Defects in this intracellular protein transport pathway give rise to severe lysosomal storage diseases...
  3. mDpy-30, intracellular protein transport, and histone methylation
    DZWOKAI Z MA; Fiscal Year: 2010
    ..aims to elucidate whether this dual localization of mDpy-30 represents a cellular mechanism to coordinate protein transport at the Golgi apparatus with gene transcription in the nucleus...
  4. SRP RNA level as a determinant of leishmanial parasitism of macrophages
    Gautam Chaudhuri; Fiscal Year: 2009
    ..Since the microbicidal functions of macrophages profoundly count on vesicular protein transport processes, down regulation of 7SL RNA may be significant in the establishment of infection by Leishmania...
  5. Secretion, protein targeting, and lipid metabolism in African Trypanosomes
    James D Bangs; Fiscal Year: 2010
    ..provided by applicant): The goal of this proposal is to understand the related processes of secretory protein transport and lipid metabolism in African trypanosomes...
  6. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2011
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  7. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    KARLETT PARRA; Fiscal Year: 2009
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  8. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  9. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  10. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  11. V-ATPase H+ PUMP REGULATION IN FUEL ENERGY SELECTION
    Karlett J Parra; Fiscal Year: 2010
    ..This study which focuses on a major problem seen in diabetes and CKD: interconnection between glucose and fats. ..
  12. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    ....
  13. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    ENRIQUE J RODRIGUEZ BOULAN; Fiscal Year: 2010
    ....
  14. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2009
    ..build an outer segment?" The proposed research examines aspects of integral membrane and peripheral membrane protein transport from photoreceptor inner segment (site of biosynthesis) to the outer segment (site of phototransduction)...
  15. Membrane Protein Trafficking in Photoreceptors
    Wolfgang Baehr; Fiscal Year: 2011
    ..build an outer segment?" The proposed research examines aspects of integral membrane and peripheral membrane protein transport from photoreceptor inner segment (site of biosynthesis) to the outer segment (site of phototransduction)...
  16. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2000
    ..carrying mutations in the clathrin heavy chain subunit revealed that clathrin participates in selective protein transport processes at the plasma membrane and the Golgi complex: endocytosis of the mating pheromone receptors, ..
  17. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 1999
    ..carrying mutations in the clathrin heavy chain subunit revealed that clathrin participates in selective protein transport processes at the plasma membrane and the Golgi complex: endocytosis of the mating pheromone receptors, ..
  18. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 1993
    ..in the clathrin heavy chain subunit revealed that clathrin plays an important role in several selective protein transport steps, including selective retention of Golgi membrane proteins, receptor-mediated endocytosis of the mating ..
  19. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2010
    ..This complexity generates several fundamental questions concerning intracellular protein transport and endoplasmic reticulum (ER) quality control function that link directly to clinical disease...
  20. Clathrin adaptor function at the trans Golgi network and endosomes
    Gregory Payne; Fiscal Year: 2007
    ..cerevisiae indicate that clathrin coated vesicles (ccv) participate in evolutionarily conserved protein transport between the TGN and endosomes...
  21. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2009
    ..This complexity generates several fundamental questions concerning intracellular protein transport and endoplasmic reticulum (ER) quality control function that link directly to clinical disease...
  22. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2010
    ..This complexity generates several fundamental questions concerning intracellular protein transport and endoplasmic reticulum (ER) quality control function that link directly to clinical disease...
  23. Clathrin adaptor function at the TGN and endosomes
    Gregory Payne; Fiscal Year: 2004
    ..cerevisiae indicate that clathrin coated vesicles (ccv) participate in evolutionarily conserved protein transport between the TGN and endosomes...
  24. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2005
    ..abstract_text> ..
  25. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2002
    ..abstract_text> ..
  26. Clathrin adaptor function at the TGN and endosomes
    Gregory Payne; Fiscal Year: 2005
    ..cerevisiae indicate that clathrin coated vesicles (ccv) participate in evolutionarily conserved protein transport between the TGN and endosomes...
  27. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2006
    ..abstract_text> ..
  28. Clathrin adaptor function at the TGN and endosomes
    Gregory Payne; Fiscal Year: 2006
    ..cerevisiae indicate that clathrin coated vesicles (ccv) participate in evolutionarily conserved protein transport between the TGN and endosomes...
  29. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2004
    ..abstract_text> ..
  30. CELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITY
    Dennis Brown; Fiscal Year: 2003
    ..abstract_text> ..
  31. Toxic Metals in the Northeast: From Biological To Environmental Implications
    BRUCE STANTON; Fiscal Year: 2009
    ....
  32. Toxic Metals in the Northeast: From Biological To Environmental Implications
    BRUCE STANTON; Fiscal Year: 2009
    ....
  33. Toxic Metals in the Northeast: From Biological To Environmental Implications
    BRUCE STANTON; Fiscal Year: 2009
    ....
  34. PROTEIN SORTING TO THE LYSOSOME-LIKE VACUOLE IN YEAST
    Scott Emr; Fiscal Year: 1992
    ..It is anticipated that these studies will result in a detailed view of the organization and control of protein sorting and vesicular traffic between the Golgi complex and the vacuole/lysosome in yeast and other eukaryotes...
  35. Intraflagellar Transport Proteins in Mice
    Gregory J Pazour; Fiscal Year: 2011
    ..Understanding the mechanisms of ciliary membrane protein transport will provide insight into the etiology of many ciliary diseases since the sensory functions of cilia depend ..
  36. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2009
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  37. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory S Payne; Fiscal Year: 2010
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  38. MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORT
    Gregory Payne; Fiscal Year: 2009
    ..The overall goal of this project is to understand the molecular basis of selective protein transport by ccv in normal cells to provide a foundation for understanding how defects can lead to disease...
  39. 2012 Intrinsically Disordered Proteins Gordon Research Conference
    Rohit V Pappu; Fiscal Year: 2012
    ..In choosing the recipients for support through NIH funds, the organizers will pay special attention to the need for drawing young scientists who are women and belong to under-represented minority groups. ..
  40. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2005
    ..abstract_text> ..
  41. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2007
    ..abstract_text> ..
  42. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2006
    ..abstract_text> ..
  43. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2004
    ..abstract_text> ..
  44. THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
    Peter Arvan; Fiscal Year: 2003
    ..abstract_text> ..
  45. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2006
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..
  46. INTRACELLULAR TRANSPORT--MANNOSE-PHOSPHATE RECEPTOR
    Suzanne Pfeffer; Fiscal Year: 1990
    ..It is hoped that these cell biological and biochemical experiments will further our understanding of the molecular mechanisms by which proteins are transported between membrane-bound compartments within the cytoplasm of eukaryotic cells...
  47. CYTOPLASMIC FUCOSYLATION
    Christopher West; Fiscal Year: 1993
    ..proliferation rate, cell sorting, pseudoplasmodial migration, spore coat formation, spore germination, and protein transport rate, in the cellular slime mold Dictyostelium discoideum...
  48. Receptor-mediated Endocytosis-Mechanism and Function
    Frederick R Maxfield; Fiscal Year: 2010
    ..The proposed work Is divided in two main themes relating to membrane protein transport (Aims l-lll) and cholesterol and lipid transport (Aims IV and V)...
  49. ISOPRENYLATED GTP-BINDING PROTEINS AND CELL GROWTH
    WILLIAM MALTESE; Fiscal Year: 1999
    ....
  50. ISOPRENYLATED GTP-BINDING PROTEINS AND CELL GROWTH
    WILLIAM MALTESE; Fiscal Year: 1999
    ....
  51. STRUCTURAL REQUIREMENTS FOR PROTEIN TRAFFICKING
    James Collawn; Fiscal Year: 1993
    ..The invariant chain/TR hybrids will be used in future studies directed at understanding how the trafficking of this molecule controls class II MHC presentation of antigen...
  52. IN VIVO STUDY OF INTERSTITIAL CONVECTION
    MICHAEL FLESSNER; Fiscal Year: 1999
    ..Recently proposed mathematical models of interstitial fluid and protein transport include theories of convection which are potentially capable of calculating interstitial pressure forces, ..
  53. Ubiquitin-like Small Archaeal Protein Modification (SAMPylation)
    Julie A Maupin Furlow; Fiscal Year: 2010
    ..Advancing our understanding of these processes will greatly assist in targeting proteasomes and Ub/Ubl-conjugation pathways for the development of new anti-cancer and anti-inflammatory drugs. ..
  54. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT CHAPKIN; Fiscal Year: 2009
    ....
  55. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2010
    ....
  56. TARGETING OF VACUOLAR PROTEINS IN YEAST
    DANIEL KLIONSKY; Fiscal Year: 1991
    ..The investigator will use yeast as a model system to study these problems since the pathways used for protein transport appear to be very similar to those in animal cells, and in addition yeast are amenable to useful genetic ..
  57. ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
    DANIEL KLIONSKY; Fiscal Year: 2002
    ..The investigator will use yeast as a model system to study these problems since the pathways used for protein transport appear to be very similar to those in animal cells, and in addition yeast are amenable to useful genetic ..
  58. ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
    DANIEL KLIONSKY; Fiscal Year: 1999
    ..The investigator will use yeast as a model system to study these problems since the pathways used for protein transport appear to be very similar to those in animal cells, and in addition yeast are amenable to useful genetic ..
  59. ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST
    DANIEL KLIONSKY; Fiscal Year: 2000
    ..The investigator will use yeast as a model system to study these problems since the pathways used for protein transport appear to be very similar to those in animal cells, and in addition yeast are amenable to useful genetic ..
  60. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 1999
    ....
  61. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 2001
    ....
  62. Protein targeting in vertebrate photoreceptors
    Sheila A Baker; Fiscal Year: 2010
    ..Elucidating the mechanisms controlling these processes is essential for developing therapeutic interventions. ..
  63. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 2000
    ....
  64. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 1999
    ....
  65. CELLULAR BIOLOGY OF RENAL FUNCTION AND DISEASE
    Dennis Brown; Fiscal Year: 2001
    ....
  66. Structural and Dynamical Response of Escherichia coli to Osmotic Stress
    JAMES WEISSHAAR; Fiscal Year: 2009
    ..In this project we study protein transport (diffusion) and the organization of proteins, DNA, and ribosomes within the cytoplasm of live cells using ..
  67. The Role of ER-stress and pH in Fluorosis
    John D Bartlett; Fiscal Year: 2010
    ..These data corroborate prior studies demonstrating F-induced ER distention (2) and defective ER to Golgi protein transport (3)...
  68. The Role of ER-stress and pH in Fluorosis
    John Bartlett; Fiscal Year: 2009
    ..These data corroborate prior studies demonstrating F-induced ER distention (2) and defective ER to Golgi protein transport (3)...
  69. Platelet granule biogenesis in health and disease
    Michael S Marks; Fiscal Year: 2010
    ..In this project, we will exploit our understanding of the formation of a different but related organelle in pigment cells to determine how the platelet granules are formed and what goes wrong in certain heritable bleeding disorders. ..
  70. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2004
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..
  71. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2005
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..
  72. CYTOPLASMIC FUCOSYLATION
    Christopher West; Fiscal Year: 1992
    ..proliferation rate, cell sorting, pseudoplasmodial migration, spore coat formation, spore germination, and protein transport rate, in the cellular slime mold Dictyostelium discoideum...
  73. Signaling Mechanisms in Drosophila Neural Development
    Kai Zinn; Fiscal Year: 2007
    ..We will also search for enhancers and suppressors of a bchs GOF eye phenotype. Candidate genes from the eye screen will be tested for modification of the bchs GOF neuromuscular phenotype and for interaction with bchs LOF mutations. ..
  74. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2005
    ..Preliminary studies on protein transport across primary cultured cell monolayers, which exhibit phenotypic and morphological traits of in vivo ..
  75. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2002
    ..Preliminary studies on protein transport across primary cultured cell monolayers, which exhibit phenotypic and morphological traits of in vivo ..
  76. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2003
    ..Preliminary studies on protein transport across primary cultured cell monolayers, which exhibit phenotypic and morphological traits of in vivo ..
  77. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2004
    ..Preliminary studies on protein transport across primary cultured cell monolayers, which exhibit phenotypic and morphological traits of in vivo ..
  78. MECHANISTIC STUDIES ON A CO2+ DEPENDENT MAP FROM E COLI
    RICHARD HOLZ; Fiscal Year: 2002
    ....
  79. MECHANISTIC STUDIES ON A CO2+ DEPENDENT MAP FROM E COLI
    RICHARD HOLZ; Fiscal Year: 2001
    ....
  80. The BCA2 Ubiquitin E3 Ligase as a Target in Breast Cancer
    Angelika Burger; Fiscal Year: 2009
    ..This project could have a major impact on mechanism-based drug discovery for modulation of RING-finger E3 ligase-mediated protein ubiquitination, not only in cancer. ..